Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EamA_dom	SLC35G3 SLC35G5 SLC35G6	7.25e-06	14	52	3	IPR000620
Domain	EamA	SLC35G3 SLC35G5 SLC35G6	7.25e-06	14	52	3	PF00892
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NCOR2 SHROOM3 ABCA2 KMT2D REPS1 COBL NLGN2 ZFPM1 MBD6 HES2 CIT TBC1D17 C6orf132	1.04e-08	1105	54	13	35748872
Pubmed	RT-PCR of fatty acid elongases.	SLC35G3 SLC35G5 SLC35G6	1.41e-08	4	54	3	9056918
Pubmed	Emergence of primate genes by retrotransposon-mediated sequence transduction.	SLC35G3 SLC35G5 SLC35G6	1.41e-08	4	54	3	17101974
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR2 KMT2D SALL1 ATN1 MNX1 SCAND1 MBD6 ZNF281	6.90e-08	351	54	8	38297188
Pubmed	Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.	KMT2D ZNF281	2.37e-06	2	54	2	29036642
Pubmed	Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics.	KMT2D CD68	1.42e-05	4	54	2	28805986
Pubmed	Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.	NCOR2 ATN1	4.94e-05	7	54	2	16481466
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR2 ZNF469 SHROOM3 SALL1 ATN1 C6orf132	5.39e-05	430	54	6	35044719
Pubmed	Human transcription factor protein interaction networks.	NCOR2 KMT2D SALL1 ATN1 MNX1 CCDC174 SEC24B MBD6 ZNF281 CIT	6.10e-05	1429	54	10	35140242
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	KMT2D SALL1 TENM4 SLC35G3 MYPN SLC35G5 SLC35G6	8.00e-05	674	54	7	37196079
Pubmed	Identification of novel CBP interacting proteins in embryonic orofacial tissue.	GAK TRIP10	8.46e-05	9	54	2	15752756
Pubmed	Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.	MNX1 NOS3	1.55e-04	12	54	2	31305241
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	BNC2 NCOR2 VPS13D SHROOM3 TENM4 MTFR1	1.80e-04	536	54	6	15840001
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2D ZNF281	1.83e-04	13	54	2	17761849
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	BNC2 NCOR2 VPS13D SHROOM3 TENM4 MTFR1	1.83e-04	538	54	6	10512203
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	NCOR2 KMT2D SEC24B ZNF281	1.95e-04	184	54	4	32908313
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	KIF13B ATN1 SEC24B ZNF281	2.53e-04	197	54	4	20811636
Pubmed	Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.	SALL1 TENM4	2.80e-04	16	54	2	27974206
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOR2 KMT2D ZNF281	2.98e-04	83	54	3	28794006
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	NCOR2 SHROOM3 SALL1 ZNF281	3.05e-04	207	54	4	26238476
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	NCOR2 SHROOM3 KMT2D TRMT2A FYB1 TBC1D17	3.41e-04	604	54	6	38803224
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B VPS13D SHROOM3 SEC24B MAP3K10 COBL C6orf132	3.58e-04	861	54	7	36931259
Pubmed	Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.	TRMT2A SESN2	3.98e-04	19	54	2	19805316
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2D HAX1	4.42e-04	20	54	2	29785026
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CCNJL NCOR2 GAK REPS1 TRMT2A HAX1 AFF4	4.98e-04	910	54	7	36736316
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	NCOR2 KMT2D	5.86e-04	23	54	2	9225980
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NCOR2 SALL1 REPS1 SEC24B ZNF281	6.27e-04	444	54	5	34795231
Pubmed	Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.	CD68 NOS3	6.94e-04	25	54	2	22536403
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D ATN1 ZNF281 AFF4	8.06e-04	268	54	4	33640491
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	MMP25 SEC24B MAP3K10 CIT	8.98e-04	276	54	4	28319085
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	CD68 DCST2 FYB1	9.83e-04	125	54	3	17062627
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KMT2D ATN1 SESN2 MBD6 ZNF281	1.02e-03	495	54	5	27705803
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VPS13D ABCA2 DSCAML1	1.10e-03	130	54	3	12421765
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	SHROOM3 SALL1	1.14e-03	32	54	2	14613977
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BNC2 SALL1 ZNF281	1.54e-03	146	54	3	23892456
Interaction	TLX1 interactions	NCOR2 KMT2D SALL1 ATN1 MNX1 ZNF281	5.75e-06	175	52	6	int:TLX1
Interaction	TBXT interactions	NCOR2 KMT2D ATN1 MNX1 ZNF281	1.21e-05	116	52	5	int:TBXT
Interaction	TOP3B interactions	NCOR2 SHROOM3 ABCA2 KMT2D REPS1 SEC24B COBL NLGN2 ZFPM1 MBD6 HES2 CIT TBC1D17 C6orf132	1.44e-05	1470	52	14	int:TOP3B
Interaction	CYP4F12 interactions	MMP25 MAP3K10 CIT	3.58e-05	25	52	3	int:CYP4F12
Interaction	PIN1 interactions	NCOR2 SSC5D REPS1 TRMT2A ATN1 MTFR1 GPR152	5.43e-05	383	52	7	int:PIN1
Interaction	GSC interactions	NCOR2 KMT2D SALL1 ATN1	7.49e-05	87	52	4	int:GSC
Interaction	TEAD1 interactions	NCOR2 KMT2D SALL1 ZNF281 CIT	8.95e-05	176	52	5	int:TEAD1
Interaction	SOX17 interactions	NCOR2 KMT2D SALL1 ZNF281	1.05e-04	95	52	4	int:SOX17
Interaction	VASP interactions	SHROOM3 REPS1 TRMT2A PCARE FYB1 C6orf132	1.06e-04	294	52	6	int:VASP
Interaction	NFIA interactions	NCOR2 KMT2D MNX1 ZNF281 CIT	1.22e-04	188	52	5	int:NFIA
Cytoband	12q24	NCOR2 CIT	4.00e-04	25	54	2	12q24
Cytoband	7q36	MNX1 NOS3	4.68e-04	27	54	2	7q36
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOR2 KMT2D	8.33e-04	25	31	2	775
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC5D CD68	9.72e-04	27	31	2	1253
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BNC2 ZNF469 ZNF142 SALL1 ZFPM1 ZNF281	1.21e-03	718	31	6	28
GeneFamily	Solute carriers	SLC35G3 SLC35G5 SLC35G6 SLC23A3	4.43e-03	395	31	4	752
Disease	Cleft Palate	BNC2 ATN1 NOS3	4.23e-04	81	53	3	C0008925
Disease	Fetal Growth Retardation	MNX1 NOS3	5.89e-04	20	53	2	C0015934
Disease	hair colour measurement	BNC2 ZNF469 SHROOM3 KMT2D TENM4 ZFPM1	8.00e-04	615	53	6	EFO_0007822
Disease	Endogenous Hyperinsulinism	CD68 NOS3	1.00e-03	26	53	2	C1257963
Disease	Exogenous Hyperinsulinism	CD68 NOS3	1.00e-03	26	53	2	C1257964
Disease	Compensatory Hyperinsulinemia	CD68 NOS3	1.00e-03	26	53	2	C1257965
Disease	Ischemia	CD68 NOS3	1.16e-03	28	53	2	C0022116
Disease	Hyperinsulinism	CD68 NOS3	1.16e-03	28	53	2	C0020459
Disease	C-reactive protein measurement	BNC2 ZNF469 SALL1 HAX1 ZFPM1 FYB1 CIT AFF4	1.31e-03	1206	53	8	EFO_0004458
Disease	non-melanoma skin carcinoma	BNC2 ZNF469 SCAND1 ZFPM1	1.32e-03	265	53	4	EFO_0009260
Disease	Cholestasis, Extrahepatic	CD68 NOS3	1.52e-03	32	53	2	C0005398
Disease	endometrial carcinoma (is_marker_for)	NCOR2 NOS3	1.71e-03	34	53	2	DOID:2871 (is_marker_for)
Disease	Congenital small ears	KMT2D SALL1	2.48e-03	41	53	2	C0152423
Disease	Cleft palate, isolated	BNC2 NOS3	2.60e-03	42	53	2	C1837218
Disease	Male sterility	KMT2D NOS3	3.39e-03	48	53	2	C0917731
Disease	Male infertility	KMT2D NOS3	3.39e-03	48	53	2	C0021364
Disease	Subfertility, Male	KMT2D NOS3	3.39e-03	48	53	2	C0848676

Protein segments in the cluster

Peptide	Gene	Start	Entry
PTSGTIEQHPPPPSE	BNC2	596	Q6ZN30
PHSLPPASSSAPAPP	ATN1	356	P54259
SNSPASAPHPPPTPP	CCNJL	121	Q8IV13
SAPHPPPTPPQVAET	CCNJL	126	Q8IV13
PAPPEGPSHPREPST	CIT	1941	O14578
PSQSASPEPEPPPTN	AFF4	456	Q9UHB7
SPGFTSSAHPEPPPP	CD68	131	P34810
SSAHPEPPPPSPSPS	CD68	136	P34810
PPASPTHSPSFPIPD	MMP25	301	Q9NPA2
PDPPAPPASASDPHR	NCOR2	2006	Q9Y618
PAPHASSSPPSDPPL	MBD6	246	Q96DN6
SDEAAPAAPSPPPSP	MAP3K10	766	Q02779
PSHPPELPGPESETP	HAX1	101	O00165
PASAPEPASAPVPSP	HES2	146	Q9Y543
EDDSPPPRPSHQPAP	MNX1	386	P50219
TSLDSGHSDPPTPPP	JPH4	161	Q96JJ6
TGSPLHEEPSPPSPQ	PLXNB1	751	O43157
ASQPPLPASHPSQPP	FYB1	401	O15117
EAPSPPSADVNSPPP	ZFPM1	41	Q8IX07
PTPSSHPTPGALEDP	GPR152	431	Q8TDT2
LPPAPEHSPPSSPLT	NOS3	46	P29474
EHSPPSSPLTQPPEG	NOS3	51	P29474
DSTTFGTIPPHPPPP	MTFR1	176	Q15390
VPAPAPPAPASPHTV	C6orf132	231	Q5T0Z8
TVPPSFPSAHSAPPP	GAK	991	O14976
LHTQSAEPPPPPEPA	CD99L2	246	Q8TCZ2
TPAEPPTAPSAAPPA	DSCAML1	1991	Q8TD84
PTAPSAAPPAPSTEP	DSCAML1	1996	Q8TD84
PDGTDPPPPHTSDTQ	COBL	1016	O75128
SNFVPPPPSPAPSDS	ABCA2	1586	Q9BZC7
PSPEHTSPTPAPDNP	CCDC174	431	Q6PII3
SVPLSPPSLPDPSHP	DCST2	756	Q5T1A1
SASSPAPDPAPEPDP	SEC24B	421	O95487
ENPASPPETFSPSPP	SALL1	76	Q9NSC2
PFPPPPPTATSHNNT	NLGN2	811	Q8NFZ4
PSPPTQHPEASPPFS	PCARE	1071	A6NGG8
AEPEAPISHPPPPTA	KIF13B	1601	Q9NQT8
PDSTHPSPPSAPPSL	SLC35G5	11	Q96KT7
PTPPSEQSSPPSRDP	SESN2	231	P58004
PDSTHPSPPSAPPSL	SLC35G3	11	Q8N808
HSPPAQPTPGPPDNT	TRMT2A	601	Q8IZ69
HSGTSPDNTAPPPPP	REPS1	536	Q96D71
PEASPPAPEPSSPNA	SCAND1	41	P57086
NSTDPSPEEPPAPSH	SHROOM3	736	Q8TF72
TPDPTTTPHPTTPDP	SSC5D	1316	A1L4H1
PAPNAPATPDAPPTT	PMIS2	11	A0A1W2PS18
APLPPPAPQNPSTHS	SLC23A3	21	Q6PIS1
HARPPDPPASAPPDS	TRIP10	486	Q15642
DPTTPEPSPAAPSPA	C10orf90	531	Q96M02
PPAEPHSPSPTASPL	TBC1D17	596	Q9HA65
STSAAPAAEPPPPPA	ZNF281	81	Q9Y2X9
PSPAPTDHSLSGEPP	TENM4	211	Q6N022
PDSTHPSPPSAPPSL	SLC35G6	11	P0C7Q6
PQETGSPFPSPEPPH	ZNF469	641	Q96JG9
SPFPSPEPPHSLPTH	ZNF469	646	Q96JG9
SDPPPPPRAHVSPQE	nan	66	Q6ZR54
EDPSPPAPAAPHTGP	ZNF142	1671	P52746
PLATPPNTPPPESSS	VPS13D	771	Q5THJ4
EPPPAQALAPSPPSH	KMT2D	2351	O14686
IEPQPSPPHSEPPSV	MYPN	556	Q86TC9