Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC6A1 GABRB3 SLC25A3 ATP1B4 SIDT2 ATP8B4 PKD2L2 SLC16A4 TRPM7 SLC6A16 ABCA12 NIPAL2 XKR8 ATG9A ASIC5 NMUR2 SLC7A6 SLC13A2 ATP10D GABRA3

1.54e-1112895120GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A1 GABRB3 SLC25A3 ATP1B4 SIDT2 PKD2L2 SLC16A4 TRPM7 SLC6A16 ABCA12 NIPAL2 ASIC5 NMUR2 SLC7A6 SLC13A2 GABRA3

2.01e-0811805116GO:0022857
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B4 ABCA12 XKR8 ATG9A ATP10D

1.91e-0751515GO:0140303
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A1 GABRB3 SLC25A3 ATP1B4 PKD2L2 TRPM7 NIPAL2 ASIC5 NMUR2 SLC13A2 GABRA3

2.61e-067585111GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A1 GABRB3 SLC25A3 PKD2L2 TRPM7 NIPAL2 ASIC5 NMUR2 SLC13A2 GABRA3

2.69e-057935110GO:0015075
GeneOntologyMolecularFunctionsymporter activity

SLC6A1 SLC25A3 SLC16A4 SLC6A16 SLC13A2

3.98e-05150515GO:0015293
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B4 ABCA12 ATP10D

4.92e-0528513GO:0140326
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A1 GABRB3 SLC25A3 NMUR2 GABRA3

7.42e-05171515GO:0015103
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A1 SLC25A3 SLC16A4 SLC6A16 SLC7A6 SLC13A2

1.04e-04296516GO:0015291
GeneOntologyMolecularFunctionlipid transporter activity

ATP8B4 ABCA12 XKR8 ATG9A ATP10D

1.41e-04196515GO:0005319
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A1 SLC25A3 ATP1B4 PKD2L2 TRPM7 NIPAL2 ASIC5 SLC13A2

1.75e-04627518GO:0022890
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A1 SLC25A3 SLC16A4 SLC6A16 ABCA12 SLC7A6 SLC13A2

1.98e-04477517GO:0022804
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRB3 NMUR2 GABRA3

2.83e-0450513GO:0099095
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A1 GABRB3 NMUR2 GABRA3

2.91e-04125514GO:0015108
GeneOntologyMolecularFunctionG protein-coupled receptor activity

TAS2R10 ADGRL1 OR6K3 TAS2R41 CCR8 NMUR2 GPR160 OR4L1 HRH3

3.58e-04884519GO:0004930
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

FADS1 FADS2B

4.90e-0413512GO:0016717
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GABRB3 TAS2R10 ADGRL1 OR6K3 TAS2R41 CCR8 NMUR2 GPR160 OR4L1 HRH3 GABRA3

5.09e-0413535111GO:0004888
GeneOntologyMolecularFunctionAP-2 adaptor complex binding

GABRB3 SIDT2

5.71e-0414512GO:0035612
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A1 GABRB3 NMUR2 GABRA3

5.96e-04151514GO:0008509
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRB3 HRH3 GABRA3

9.31e-0475513GO:0098960
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRB3 GABRA3

9.53e-0418512GO:0022851
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRB3 GABRA3

1.06e-0319512GO:0004890
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRB3 PKD2L2 TRPM7 ASIC5 NMUR2 GABRA3

1.07e-03459516GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A1 PKD2L2 TRPM7 NIPAL2 ASIC5 SLC13A2

1.15e-03465516GO:0046873
GeneOntologyMolecularFunctionchloride channel activity

GABRB3 NMUR2 GABRA3

1.38e-0386513GO:0005254
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A1 SLC25A3 PKD2L2 TRPM7 NIPAL2 ASIC5 SLC13A2

1.41e-03664517GO:0008324
GeneOntologyMolecularFunctionGABA receptor activity

GABRB3 GABRA3

1.43e-0322512GO:0016917
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRB3 ASIC5 NMUR2 GABRA3

1.48e-03193514GO:0015276
GeneOntologyMolecularFunctionphospholipid scramblase activity

XKR8 ATG9A

1.56e-0323512GO:0017128
GeneOntologyMolecularFunctionligand-gated channel activity

GABRB3 ASIC5 NMUR2 GABRA3

1.60e-03197514GO:0022834
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A1 SLC16A4 SLC7A6 SLC13A2

1.92e-03207514GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A1 SLC16A4 SLC7A6 SLC13A2

1.95e-03208514GO:0005342
GeneOntologyMolecularFunctionchannel activity

GABRB3 PKD2L2 TRPM7 ASIC5 NMUR2 GABRA3

2.12e-03525516GO:0015267
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRB3 HRH3 GABRA3

2.13e-03100513GO:0030594
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRB3 PKD2L2 TRPM7 ASIC5 NMUR2 GABRA3

2.14e-03526516GO:0022803
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R10 TAS2R41

2.16e-0327512GO:0033038
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRB3 NMUR2 GABRA3

2.32e-03103513GO:0005253
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R10 TAS2R41

3.21e-0333512GO:0008527
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A1 SLC25A3 SLC13A2

3.49e-03119513GO:0015294
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A1 SLC13A2

3.61e-0335512GO:0005343
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

PIP SPPL3

4.02e-0337512GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

PIP SPPL3

4.24e-0338512GO:0070001
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC6A1 SLC16A4 SLC7A6 SLC13A2

6.61e-03293514GO:0008514
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GABRB3 GABRA3

9.33e-0357512GO:1904315
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A1 ASIC5 SLC13A2

9.51e-03171513GO:0015081
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GABRB3 GABRA3

1.03e-0260512GO:0099529
GeneOntologyMolecularFunctiongated channel activity

GABRB3 ASIC5 NMUR2 GABRA3

1.04e-02334514GO:0022836
GeneOntologyMolecularFunctionNADP binding

GMDS LBR

1.10e-0262512GO:0050661
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRB3 GABRA3

1.20e-0265512GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRB3 GABRA3

1.20e-0265512GO:0022824
GeneOntologyMolecularFunctionphospholipid transporter activity

XKR8 ATG9A

1.54e-0274512GO:0005548
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRB3 GABRA3

1.66e-0277512GO:0005230
GeneOntologyBiologicalProcesslipid translocation

ATP8B4 ABCA12 XKR8 ATG9A ATP10D

3.72e-0760515GO:0034204
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ATP8B4 ABCA12 XKR8 ATG9A ATP10D

5.58e-0765515GO:0097035
GeneOntologyBiologicalProcessorganophosphate ester transport

ATP8B4 G6PC3 ABCA12 XKR8 ATG9A ATP10D

2.88e-06162516GO:0015748
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A1 GABRB3 SLC25A3 ATP1B4 PKD2L2 TRPM7 SLC6A16 NIPAL2 ASIC5 NMUR2 SLC13A2 ATP10D HRH3 GABRA3

3.97e-0613745114GO:0006811
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A1 GABRB3 SLC25A3 ATP1B4 PKD2L2 TRPM7 SLC6A16 NIPAL2 ASIC5 NMUR2 SLC13A2 GABRA3

5.16e-0610175112GO:0098660
GeneOntologyBiologicalProcessphospholipid transport

ATP8B4 ABCA12 XKR8 ATG9A ATP10D

6.34e-06106515GO:0015914
GeneOntologyBiologicalProcessphospholipid translocation

ATP8B4 XKR8 ATG9A ATP10D

1.03e-0555514GO:0045332
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A1 GABRB3 SLC25A3 PKD2L2 TRPM7 SLC6A16 NIPAL2 ASIC5 NMUR2 SLC13A2 ATP10D GABRA3

1.31e-0511155112GO:0034220
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC6A1 GABRB3 SLC25A3 NMUR2 GABRA3

1.98e-05134515GO:0098661
GeneOntologyBiologicalProcessinorganic anion transport

SLC6A1 GABRB3 SLC25A3 NMUR2 GABRA3

8.12e-05180515GO:0015698
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC6A1 GABRB3 NMUR2 GABRA3

1.69e-04112514GO:1902476
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of bitter taste

TAS2R10 PIP TAS2R41

1.76e-0444513GO:0001580
GeneOntologyBiologicalProcesssensory perception of bitter taste

TAS2R10 PIP TAS2R41

2.28e-0448513GO:0050913
GeneOntologyBiologicalProcesslipid transport

ATP8B4 ABCA12 XKR8 ATG9A NMUR2 ATP10D HRH3

2.33e-04506517GO:0006869
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R10 PIP TAS2R41

2.57e-0450513GO:0050912
GeneOntologyBiologicalProcessorganic anion transport

SLC6A1 G6PC3 SLC16A4 NMUR2 SLC7A6 SLC13A2 HRH3

2.60e-04515517GO:0015711
GeneOntologyBiologicalProcesschloride transport

SLC6A1 GABRB3 NMUR2 GABRA3

2.82e-04128514GO:0006821
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A1 SLC25A3 ATP1B4 PKD2L2 TRPM7 SLC6A16 NIPAL2 ASIC5 SLC13A2

3.84e-04922519GO:0098662
GeneOntologyBiologicalProcesslipid localization

ATP8B4 ABCA12 XKR8 ATG9A NMUR2 ATP10D HRH3

4.54e-04565517GO:0010876
GeneOntologyBiologicalProcessregulation of gamma-aminobutyric acid secretion

SLC6A1 HRH3

4.59e-0413512GO:0014052
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A1 SLC25A3 ATP1B4 PKD2L2 TRPM7 SLC6A16 NIPAL2 ASIC5 SLC13A2 ATP10D

4.61e-0411575110GO:0006812
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC6A1 SLC16A4 NMUR2 SLC7A6 SLC13A2 HRH3

5.03e-04410516GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

SLC6A1 SLC16A4 NMUR2 SLC7A6 SLC13A2 HRH3

5.16e-04412516GO:0015849
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC6A1 GABRB3 NMUR2 GABRA3

5.55e-04153514GO:0098656
GeneOntologyBiologicalProcesssodium ion transport

SLC6A1 ATP1B4 SLC6A16 ASIC5 SLC13A2

5.78e-04275515GO:0006814
GeneOntologyBiologicalProcesssensory perception of taste

TAS2R10 PIP TAS2R41

6.94e-0470513GO:0050909
GeneOntologyBiologicalProcesssynaptic transmission, GABAergic

SLC6A1 GABRB3 GABRA3

8.16e-0474513GO:0051932
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC6A1 GABRB3 NMUR2 GABRA3

1.08e-03183514GO:0006820
GeneOntologyBiologicalProcessmemory

SLC6A1 GABRB3 TRPM7 HRH3

1.08e-03183514GO:0007613
GeneOntologyBiologicalProcessgamma-aminobutyric acid secretion

SLC6A1 HRH3

1.11e-0320512GO:0014051
MousePhenoabnormal GABA-mediated receptor currents

SLC6A1 GABRB3 GABRA3

1.59e-0518393MP:0004008
DomainHydrolase_3

ATP8B4 ATP10D

2.99e-0410492PF08282
DomainP_typ_ATPase_c

ATP8B4 ATP10D

6.01e-0414492IPR032630
DomainP-type_ATPase_N

ATP8B4 ATP10D

6.01e-0414492IPR032631
DomainP-type_ATPase_IV

ATP8B4 ATP10D

6.01e-0414492IPR006539
DomainPhoLip_ATPase_C

ATP8B4 ATP10D

6.01e-0414492PF16212
DomainPhoLip_ATPase_N

ATP8B4 ATP10D

6.01e-0414492PF16209
DomainNA_NEUROTRAN_SYMP_2

SLC6A1 SLC6A16

1.00e-0318492PS00754
DomainNA_NEUROTRAN_SYMP_3

SLC6A1 SLC6A16

1.12e-0319492PS50267
DomainPA

RNF130 RNF150

1.12e-0319492PF02225
DomainPA_domain

RNF130 RNF150

1.12e-0319492IPR003137
DomainSNF

SLC6A1 SLC6A16

1.12e-0319492PF00209
DomainNa/ntran_symport

SLC6A1 SLC6A16

1.12e-0319492IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A1 SLC6A16

1.12e-0319492PS00610
DomainGABAA/Glycine_rcpt

GABRB3 GABRA3

1.65e-0323492IPR006028
DomainTAS2R

TAS2R10 TAS2R41

2.11e-0326492PF05296
DomainT2R

TAS2R10 TAS2R41

2.11e-0326492IPR007960
Domain-

ATP8B4 ATP10D

3.18e-03324922.70.150.10
Domain-

ATP8B4 ATP10D

3.18e-03324923.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP8B4 ATP10D

3.80e-0335492IPR023299
DomainATPase_P-typ_P_site

ATP8B4 ATP10D

4.01e-0336492IPR018303
DomainP_typ_ATPase

ATP8B4 ATP10D

4.01e-0336492IPR001757
DomainATPASE_E1_E2

ATP8B4 ATP10D

4.01e-0336492PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B4 ATP10D

4.24e-0337492IPR008250
DomainE1-E2_ATPase

ATP8B4 ATP10D

4.24e-0337492PF00122
DomainNeurotransmitter_ion_chnl_CS

GABRB3 GABRA3

6.21e-0345492IPR018000
DomainNeur_chan_memb

GABRB3 GABRA3

6.48e-0346492PF02932
DomainNeur_chan_LBD

GABRB3 GABRA3

6.76e-0347492PF02931
DomainNeur_channel

GABRB3 GABRA3

6.76e-0347492IPR006201
DomainNeur_chan_lig-bd

GABRB3 GABRA3

6.76e-0347492IPR006202
DomainNEUROTR_ION_CHANNEL

GABRB3 GABRA3

6.76e-0347492PS00236
DomainNeurotrans-gated_channel_TM

GABRB3 GABRA3

6.76e-0347492IPR006029
Domain-

GABRB3 GABRA3

6.76e-03474922.70.170.10
DomainGPCR_Rhodpsn_7TM

OR6K3 CCR8 NMUR2 GPR160 OR4L1 HRH3

7.85e-03670496IPR017452
Domainzf-RING_2

RNF130 RNF150

8.22e-0352492PF13639
DomainG_PROTEIN_RECEP_F1_1

OR6K3 CCR8 NMUR2 GPR160 OR4L1 HRH3

8.71e-03685496PS00237
DomainG_PROTEIN_RECEP_F1_2

OR6K3 CCR8 NMUR2 GPR160 OR4L1 HRH3

9.07e-03691496PS50262
DomainGPCR_Rhodpsn

OR6K3 CCR8 NMUR2 GPR160 OR4L1 HRH3

9.13e-03692496IPR000276
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A1 ATP8B4 TRPM7 ABCA12 PIP NIPAL2 ASIC5 SLC7A6 SLC13A2 ATP10D

8.94e-066813810MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A1 ATP8B4 TRPM7 ABCA12 PIP NIPAL2 ASIC5 SLC7A6 SLC13A2 ATP10D

1.76e-057363810M27287
PathwayWP_GPCRS_NONODORANT

TAS2R10 ADGRL1 TAS2R41 CCR8 NMUR2 HRH3

7.09e-05266386MM15843
PathwayWP_GABA_RECEPTOR_SIGNALING

SLC6A1 GABRB3 GABRA3

7.71e-0531383M39369
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

SLC6A1 GABRB3 GABRA3

2.53e-061852318985723
Pubmed

Anterograde trafficking signals in GABAA subunits are required for functional expression.

GABRB3 GABRA3

6.57e-06352231610743
Pubmed

Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: an immunohistochemical study.

GABRB3 GABRA3

6.57e-06352218085588
Pubmed

GABA(A) receptor downregulation in brains of subjects with autism.

GABRB3 GABRA3

1.31e-05452218821008
Pubmed

The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development.

RNF130 RNF150

3.28e-05652212435366
Pubmed

Developmental changes in the expression of gamma-aminobutyric acidA/benzodiazepine receptor subunit mRNAs in the murine inferior olivary complex.

GABRB3 GABRA3

4.58e-0575227560270
Pubmed

Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.

GABRB3 GABRA3

4.58e-05752220843900
Pubmed

Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.

GABRB3 GABRA3

4.58e-05752216101898
Pubmed

gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.

GABRB3 GABRA3

6.10e-0585228175718
Pubmed

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.

GABRB3 GABRA3

6.10e-05852218185516
Pubmed

GABA influences the development of the ventromedial nucleus of the hypothalamus.

GABRB3 GABRA3

6.10e-05852211745664
Pubmed

GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.

GABRB3 GABRA3

6.10e-05852211528422
Pubmed

Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein.

ATM APOBEC3F

6.10e-05852223202519
Pubmed

Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells.

TAS2R10 TAS2R41

6.10e-05852211854532
Pubmed

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.

GABRB3 GABRA3

1.20e-041152238894703
Pubmed

The biochemical anatomy of cortical inhibitory synapses.

GABRB3 GABRA3

1.97e-041452222768092
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRB3 GABRA3

3.30e-041852219078961
Pubmed

Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.

GABRB3 GABRA3

4.52e-042152225708312
Pubmed

A novel family of mammalian taste receptors.

TAS2R10 TAS2R41

4.52e-042152210761934
Pubmed

A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.

TAS2R10 TAS2R41

4.52e-042152237045597
Pubmed

Evolutionary relationships of the Tas2r receptor gene families in mouse and human.

TAS2R10 TAS2R41

4.97e-042252212734386
Pubmed

The molecular receptive ranges of human TAS2R bitter taste receptors.

TAS2R10 TAS2R41

5.44e-042352220022913
Pubmed

Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes.

GABRB3 GABRA3

5.93e-04245229606417
Pubmed

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.

SLC25A3 KIF14

5.93e-042452223209302
Pubmed

Receptors for bitter and sweet taste.

TAS2R10 TAS2R41

6.43e-042552212139982
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R10 TAS2R41

6.96e-042652211696554
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R10 TAS2R41

7.51e-042752212581520
Pubmed

An introduction to TRP channels.

PKD2L2 TRPM7

7.51e-042752216460286
Pubmed

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

TAS2R10 TAS2R41

8.08e-042852215744053
Pubmed

Adaptive diversification of bitter taste receptor genes in Mammalian evolution.

TAS2R10 TAS2R41

9.29e-043052212679530
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

SLC6A1 GABRB3 GABRA3

9.43e-0412852319058789
Pubmed

miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.

SLC6A1 GABRB3

9.92e-043152237816598
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

PKD2L2 TRPM7

1.12e-033352219834762
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R10 TAS2R41

1.19e-033452215496549
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

ATM ATG9A STT3B

1.49e-0315052332423001
InteractionPOMT2 interactions

ATP1B4 SIDT2 SPPL3 GABRA3

1.36e-0560494int:POMT2
InteractionFZD8 interactions

TMEM169 SIDT2 SPPL3

2.31e-0523493int:FZD8
InteractionGABRD interactions

SIDT2 CCR8 ATG9A

2.99e-0525493int:GABRD
InteractionGPR21 interactions

SIDT2 FADS1 XKR8 ADGRL1

4.47e-0581494int:GPR21
InteractionROGDI interactions

SPPL3 KIF14 ATG9A

7.00e-0533493int:ROGDI
InteractionEDIL3 interactions

SPPL3 KIF14 ADGRL1

8.37e-0535493int:EDIL3
InteractionTPRA1 interactions

SPPL3 ATG9A SNX13

9.11e-0536493int:TPRA1
InteractionADGRL3 interactions

TMEM169 SPPL3 ADGRL1

1.07e-0438493int:ADGRL3
InteractionCHRNB2 interactions

RNF130 SIDT2 SPPL3 ADGRL1

1.14e-04103494int:CHRNB2
InteractionPTPN1 interactions

SLC25A3 RNF130 TMEM169 TRPM7 KIF14 ATG9A LBR STT3B

1.20e-04625498int:PTPN1
InteractionRHOJ interactions

SLC25A3 FADS1 TRPM7 KIF14 ADGRL1 LBR SLC7A6 STT3B

1.31e-04633498int:RHOJ
InteractionSHANK1 interactions

SLC6A1 KIF14 ADGRL1

1.35e-0441493int:SHANK1
InteractionHTR3A interactions

RNF130 SIDT2 SPPL3 ATG9A

1.37e-04108494int:HTR3A
InteractionNTN3 interactions

SPPL3 KIF14

1.61e-048492int:NTN3
InteractionDBX2 interactions

KIF14 STT3B

1.61e-048492int:DBX2
InteractionSMTN interactions

PIP SPPL3 KIF14

1.67e-0444493int:SMTN
InteractionAP3B2 interactions

KIF14 ATM ATG9A

1.78e-0445493int:AP3B2
InteractionRHOF interactions

FADS1 TRPM7 SPPL3 KIF14 ADGRL1 LBR SLC7A6 STT3B

1.99e-04673498int:RHOF
InteractionASIC5 interactions

ASIC5 STT3B

2.06e-049492int:ASIC5
CytobandEnsembl 112 genes in cytogenetic band chr2q35

TMEM169 ABCA12 ATG9A

4.33e-04129523chr2q35
GeneFamilySolute carriers

SLC6A1 SLC25A3 SLC16A4 SLC6A16 SLC7A6 SLC13A2

2.14e-04395406752
GeneFamilyATPase phospholipid transporting

ATP8B4 ATP10D

4.92e-04154021210
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRB3 GABRA3

7.97e-0419402563
GeneFamilyTransient receptor potential cation channels

PKD2L2 TRPM7

1.74e-0328402249
GeneFamilyTaste 2 receptors

TAS2R10 TAS2R41

3.36e-03394021162
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

ATP8B4 TRPM7 KIF14 LBR SLC7A6

2.24e-06185515a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

ATP8B4 TRPM7 KIF14 LBR SLC7A6

2.30e-061865158571956890fc9894d766ba294a28e376b4aba428
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma|TCGA-Brain / Sample_Type by Project: Shred V9

SLC6A1 GABRB3 HRH3 GABRA3

3.46e-051615145f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRB3 ATP1B4 ADGRL1 GABRA3

5.12e-0517851430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellHSPCs-Neutro_prog.|World / Lineage and Cell class

ATP8B4 G6PC3 GPR160 STT3B

5.58e-05182514f2512354b90f55bf4172c28084bf52cf79e41d8a
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

RNF130 RNF150 ATP8B4 DNAAF9

5.95e-051855148207f9eff113eed429e961748c6b17d672a13b33
ToppCell(5)_Glands_duct|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

RNF150 PIP GMDS SLC13A2

6.07e-05186514ad8d5010e5095508f4995e0c6c016a44e8ffb8dd
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

RNF130 RNF150 ATP8B4 DNAAF9

6.59e-05190514f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

ATP8B4 TRPM7 LBR SLC7A6

6.73e-051915149454f642c3621370fa23640b631301346b300950
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

RNF130 RNF150 ATP8B4 GPR137B

7.01e-0519351431c0978ba78c9516d498aec0798902e57555e557
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATRNL1 PIP GMDS SLC13A2

7.29e-05195514cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATRNL1 PIP GMDS SLC13A2

7.29e-0519551406b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

RNF130 ATP8B4 GPR137B DNAAF9

7.29e-05195514c172c5599379c29123340621a36bfb1fc90c2115
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATRNL1 PIP GMDS SLC13A2

7.29e-0519551424a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RNF150 ABCA12 ATRNL1 XKR8

7.44e-05196514ce13af36fc2932e8125013041742593ff3d07e86
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RNF150 ABCA12 ATRNL1 XKR8

7.44e-0519651496e5c6d155273e82ebafa180df8bb589c3e3e54e
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

RNF150 PIP SLC13A2 GPR160

7.89e-05199514ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RNF130 RNF150 ATP8B4 GPR137B

8.04e-05200514ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
Drugpentylenetetrazol

SLC6A1 GABRB3 GRINA HRH3 GABRA3

9.69e-06130505CID000005917
Drugauto inducer 2

TAS2R10 ATM SLC13A2

1.71e-0523503CID000448719
Druggabapentin

SLC6A1 GABRB3 ASIC5 GRINA GABRA3

3.43e-05169505CID000003446
DrugAC1L1B1W

SLC6A1 GABRB3 GRINA GABRA3

3.49e-0584504CID000001248
Drugpropofol

SLC6A1 GABRB3 ASIC5 GRINA GABRA3

6.15e-05191505CID000004943
Drugflurazepam

SLC6A1 GABRB3 GABRA3

6.21e-0535503CID000003393
DrugBenzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A

SIDT2 NIPAL2 ADGRL1 ATG9A SLC7A6

6.95e-051965051679_DN
DrugPanthenol (D) [81-13-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A

SIN3B SIDT2 NIPAL2 ATM GRINA

7.12e-051975051680_DN
DrugOndansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

SIDT2 PKD2L2 ATRNL1 PIP SNX13

7.29e-051985053575_UP
DrugAztreonam [78110-38-0]; Up 200; 9.2uM; HL60; HG-U133A

TM9SF4 ATM LBR SLC7A6 HRH3

7.29e-051985051435_UP
Drugsipatrigine

SLC6A1 SLC6A16 ASIC5

7.35e-0537503CID000060803
Drugsecobarbital

SLC6A1 GABRB3 GABRA3

7.35e-0537503CID000005193
DrugMetampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A

SIDT2 SLC16A4 SLC6A16 TM9SF4 ADGRL1

7.47e-051995055540_UP
DrugDMCM

SLC6A1 GABRB3 GABRA3

7.96e-0538503CID000104999
Drugzaleplon

SLC6A1 GABRB3 GABRA3

8.61e-0539503CID000005719
DrugQuazepam

GABRB3 GABRA3

9.86e-057502DB01589
Druggaboxadol

SLC6A1 GABRB3 GABRA3

1.00e-0441503CID000003448
Drugfentanyl

PIP ADGRL1 LBR GRINA

1.04e-04111504CID000003345
Drugzolpidem

SLC6A1 GABRB3 GABRA3

1.16e-0443503CID000005732
Drughydroxybutyrate

GABRB3 RNF130 GRINA GABRA3

1.19e-04115504CID000010413
Drugpentobarbital

GABRB3 ASIC5 LBR GRINA GABRA3

1.30e-04224505CID000004737
DrugAdinazolam

GABRB3 GABRA3

1.31e-048502DB00546
DrugFludiazepam

GABRB3 GABRA3

1.31e-048502DB01567
DrugClotiazepam

GABRB3 GABRA3

1.31e-048502DB01559
DrugCinolazepam

GABRB3 GABRA3

1.31e-048502DB01594
DrugPrazepam

GABRB3 GABRA3

1.31e-048502DB01588
DrugEstazolam

GABRB3 GABRA3

1.31e-048502DB01215
DrugHalazepam

GABRB3 GABRA3

1.31e-048502DB00801
Drug1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane

GABRB3 GABRA3

1.31e-048502ctd:C091518
Drugthymol

GABRB3 TRPM7 GABRA3

1.42e-0446503CID000006989
Drugtaurine

SLC6A1 GABRB3 SLC6A16 GRINA GABRA3

1.50e-04231505CID000001123
DrugEthchlorvynol

GABRB3 GABRA3

1.68e-049502DB00189
DrugDiazepam

GABRB3 GABRA3

1.68e-049502DB00829
Drugvigabatrin

SLC6A1 GABRB3 GABRA3

1.71e-0449503CID000005665
Drugmuscimol

SLC6A1 GABRB3 GRINA GABRA3

1.85e-04129504CID000004266
Drugsodium

SLC6A1 GABRB3 SLC25A3 TRPM7 SLC6A16 ASIC5 SLC7A6 SLC13A2 GABRA3

1.89e-04944509CID000000923
DrugChlordiazepoxide

GABRB3 GABRA3

2.10e-0410502DB00475
DrugClobazam

GABRB3 GABRA3

2.10e-0410502DB00349
DrugBromazepam

GABRB3 GABRA3

2.10e-0410502DB01558
DrugClonazepam

GABRB3 GABRA3

2.10e-0410502DB01068
DrugOxazepam

GABRB3 GABRA3

2.10e-0410502DB00842
DrugMidazolam

GABRB3 GABRA3

2.10e-0410502DB00683
DrugFlurazepam

GABRB3 GABRA3

2.10e-0410502DB00690
DrugAlprazolam

GABRB3 GABRA3

2.57e-0411502DB00404
DrugTemazepam

GABRB3 GABRA3

2.57e-0411502DB00231
DrugNitrazepam

GABRB3 GABRA3

2.57e-0411502DB01595
DrugLorazepam

GABRB3 GABRA3

2.57e-0411502DB00186
DrugAC1L2F0S

RNF130 HRH3

2.57e-0411502CID000070859
DrugTriazolam

GABRB3 GABRA3

2.57e-0411502DB00897
Drugoxiracetam

SLC25A3 GRINA

2.57e-0411502CID000004626
DrugClorazepate

GABRB3 GABRA3

2.57e-0411502DB00628
Drugbenzodiazepine

SLC6A1 GABRB3 GRINA GABRA3

2.67e-04142504CID000134664
Drugketamine

GABRB3 ASIC5 LBR GRINA GABRA3

2.70e-04262505CID000003821
Drugflunitrazepam

SLC6A1 GABRB3 GABRA3

2.97e-0459503CID000003380
DrugAC1Q5UBL

SLC6A1 GABRB3 SLC6A16 GABRA3

2.97e-04146504CID000005466
DrugTAK-220

RNF130 APOBEC3F

3.08e-0412502CID005275766
Drugpyrrolidine-2,4-dicarboxylate

SLC6A1 SLC6A16 GRINA

3.28e-0461503CID000003868
Drugtetradotoxin

SLC6A1 GABRB3 ASIC5 GRINA HRH3 GABRA3

3.36e-04428506CID000020382
Druggamma-Aminobutyric Acid

SLC6A1 GABRB3 GABRA3

3.44e-0462503ctd:D005680
Drugbenzo(k)fluoranthene

ABCA12 SPPL3 NIPAL2 SLC13A2 GPR160 STT3B GABRA3

3.52e-04610507ctd:C022921
Drugisoflurane

GABRB3 ASIC5 LBR GRINA GABRA3

3.60e-04279505CID000003763
DrugAC1NRNSN

PIP SLC7A6 STT3B

3.61e-0463503CID005244174
Disease1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) measurement

SIDT2 FADS1

8.88e-059472EFO_0800409
Disease1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) measurement

SIDT2 FADS1

8.88e-059472EFO_0800403
Disease1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) measurement

SIDT2 FADS1

8.88e-059472EFO_0800272
Disease1-stearoyl-2-linoleoyl-GPE (18:0/18:2) measurement

SIDT2 FADS1

1.11e-0410472EFO_0800402
Diseasecholesteryl ester 22:5 measurement

SIDT2 FADS1

1.11e-0410472EFO_0021444
Diseasephosphatidylcholine 32:0 measurement

GABRB3 FADS1

1.35e-0411472EFO_0010372
Diseaselevel of Phosphatidylcholine (16:0_16:0) in blood serum

FADS1 SNX13

2.57e-0415472OBA_2045067
Diseasesciatic neuropathy (implicated_via_orthology)

CASP12 HRH3

6.15e-0423472DOID:11446 (implicated_via_orthology)
Diseasegamma-linolenic acid measurement

FADS1 SNX13

6.70e-0424472EFO_0007762
DiseaseAmyotrophic Lateral Sclerosis, Guam Form

SLC6A1 TRPM7

1.12e-0331472C0543859
Diseasecholesteryl ester 22:6 measurement

SIDT2 FADS1

1.19e-0332472EFO_0010350
Diseaselysophosphatidylethanolamine 18:1 measurement

SIDT2 FADS1

1.35e-0334472EFO_0010368
Diseasecholesteryl ester 18:3 measurement

SIDT2 FADS1

1.86e-0340472EFO_0010346
Diseasemetabolite measurement

ATP8B4 FADS1 SPPL3 SLC7A6 ATP10D

1.92e-03560475EFO_0004725
Diseasesusceptibility to infectious disease measurement

RNF150 ATRNL1

2.05e-0342472EFO_0008422
Diseasecholesteryl ester 20:4 measurement

SIDT2 FADS1

2.25e-0344472EFO_0010348
DiseaseGastric Adenocarcinoma

TRPM7 ATM

2.35e-0345472C0278701
Diseaselung adenocarcinoma

ATP8B4 FADS1 ATM

2.70e-03174473EFO_0000571
Diseaseglycerophospholipid measurement

SIDT2 FADS1

2.78e-0349472EFO_0007630
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRB3 SIN3B

2.78e-0349472DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SFIYFLIAWYVRNVF

ABCA12

1261

Q86UK0
LYVWNNYFVVRYSLE

ADGRL1

381

O94910
VYDQWFITLFNIVYT

ATP8B4

901

Q8TF62
FISQIIYYFREYSWS

CASP12

286

Q6UXS9
GQSWSLILLIYFFFY

ATP1B4

106

Q9UN42
YFFYKNVAYVNLLFW

ATP10D

1116

Q9P241
AWLIFYFIQKIRYTN

RNF130

211

Q86XS8
LVWVPFIYSFQAFYL

LBR

461

Q14739
YNFISIFSFLEIWYT

OR6K3

76

Q8NGY3
KQVYNFIYDVSFWSF

KIF14

396

Q15058
TALQWFIYDSVKVYF

SLC25A3

326

Q00325
NVWTYYVSYAVFFIS

GRINA

196

Q7Z429
WIYNFIIQVTSFLFY

NMUR2

211

Q9GZQ4
AYWIVVNFREAYNLF

GMDS

186

O60547
ISLFYIFNFLKYTLW

G6PC3

306

Q9BUM1
WELQIFFFVTFSLIY

OR4L1

21

Q8NH43
LFAIFNLVYWATYVN

GABRA3

466

P34903
FPFTFSLFNLVYWLY

GABRB3

456

P28472
QDITWVSSFYIYFIT

FADS2B

336

A8MWK0
YFVNSFLIATVYWFN

GPR160

281

Q9UJ42
NVNLTIFTARLYYFW

APOBEC3F

296

Q8IUX4
QQQWLELFSVYFRLY

ATM

161

Q13315
FSFPFQTYYLLDQWV

CCR8

86

P51685
IWQILYAFFSYAEVL

ATG9A

306

Q7Z3C6
IYQAFYSEVFSLWKQ

DNAAF9

636

Q5TEA3
YLFTNFYWICIFFLL

ASIC5

466

Q9NY37
NITFYVYVSNFSWPI

ATRNL1

1201

Q5VV63
PLYFQWYIFYFVIQR

FADS1

276

O60427
EFFYNWYFLITASTL

HRH3

191

Q9Y5N1
QALWAYRSYLIVFFV

SLC13A2

6

Q13183
IISLAWLVFYYIQRF

RNF150

221

Q9ULK6
VFYALLFVFIYVQLW

GPR137B

51

O60478
YFLKIANFSNYIFLW

TAS2R10

106

Q9NYW0
LLFFWVNYPVYQEFL

TAS2R41

146

P59536
QVIQFSLRDYVQYWY

SNX13

106

Q9Y5W8
LGLYFNVVNSWIIFY

SLC6A16

196

Q9GZN6
YQIYFWNIATIAVFY

SIDT2

446

Q8NBJ9
IVIISWAIYYLYNSF

SLC6A1

141

P30531
RTVQYYLVGWQFLIY

NIPAL2

171

Q9H841
VYSLFFANNNWYFFL

SIN3B

771

O75182
KTFYWDFYTNRTVQI

PIP

96

P12273
IKFLLSVVQSYFVYW

REELD1

141

A0A1B0GV85
WENQFYYLFGFLFLV

TM9SF4

526

Q92544
FYIFTWSFLLSQLAY

SLC16A4

301

O15374
ITLFPFISWVYIYIN

TMEM220

131

Q6QAJ8
AIFALQFTYYLWVKS

STT3B

226

Q8TCJ2
VFWVFFSAYIFNSNV

SPPL3

201

Q8TCT6
IYYNNIIAITIFFAW

PKD2L2

366

Q9NZM6
VFQLINYFSFSYWFF

SLC7A6

386

Q92536
FVVSFYYGTITWYNI

TMEM169

176

Q96HH4
WLTPFLQAVYLFVQY

TRPM7

1071

Q96QT4
YRVTVATILYFSWFN

XKR8

261

Q9H6D3