Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B KDM5C KDM5D	1.58e-06	6	87	3	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5B KDM5C KDM5D	4.40e-06	8	87	3	GO:0032453
GeneOntologyMolecularFunction	acyltransferase activity	BRPF3 RNF152 UBE2L6 RNF151 KMT2C NEURL3 FBXO9 BRCA1 LTN1 SHPRH ANKIB1 ING4 TRIM13 TOPORS	6.11e-06	775	87	14	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RNF152 UBE2L6 RNF151 NEURL3 FBXO9 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	6.49e-06	473	87	11	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF152 UBE2L6 RNF151 NEURL3 FBXO9 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	1.37e-05	512	87	11	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF152 UBE2L6 RNF151 NEURL3 FBXO9 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	1.95e-05	532	87	11	GO:0016755
GeneOntologyMolecularFunction	histone modifying activity	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C ING4	6.39e-05	229	87	7	GO:0140993
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF152 RNF151 NEURL3 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	2.18e-04	372	87	8	GO:0061630
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5B KDM5C KDM5D	2.42e-04	28	87	3	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5B KDM5C KDM5D	3.29e-04	31	87	3	GO:0032452
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF152 RNF151 NEURL3 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	3.44e-04	398	87	8	GO:0061659
GeneOntologyMolecularFunction	protein demethylase activity	KDM5B KDM5C KDM5D	3.62e-04	32	87	3	GO:0140457
GeneOntologyMolecularFunction	histone H3K14 acetyltransferase activity	BRPF3 ING4	6.62e-04	9	87	2	GO:0036408
GeneOntologyMolecularFunction	demethylase activity	KDM5B KDM5C KDM5D	9.30e-04	44	87	3	GO:0032451
GeneOntologyMolecularFunction	histone H4K8 acetyltransferase activity	BRPF3 ING4	1.01e-03	11	87	2	GO:0043996
GeneOntologyMolecularFunction	histone H4K5 acetyltransferase activity	BRPF3 ING4	1.01e-03	11	87	2	GO:0043995
GeneOntologyMolecularFunction	complement component C3b binding	CFH CR1L	1.20e-03	12	87	2	GO:0001851
GeneOntologyMolecularFunction	histone H4K12 acetyltransferase activity	BRPF3 ING4	1.20e-03	12	87	2	GO:0043997
GeneOntologyMolecularFunction	zinc ion binding	KDM5B APOBEC3D MID2 KDM5C NSD1 RNF151 ZGLP1 BRCA1 LTN1 ANKIB1 TRIM13	1.66e-03	891	87	11	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	KDM5B APOBEC3D MID2 KDM5C NSD1 XDH SNAI3 RNF151 ZGLP1 BRCA1 LTN1 ANKIB1 TRIM13	1.86e-03	1189	87	13	GO:0046914
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	BRPF3 ING4	1.90e-03	15	87	2	GO:0010484
GeneOntologyMolecularFunction	transcription coactivator activity	MID2 CALCOCO1 KMT2C BRCA1 ING4 TRIM13	2.10e-03	303	87	6	GO:0003713
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM5B KDM5C KDM5D	2.87e-03	65	87	3	GO:0016706
GeneOntologyMolecularFunction	transcription coregulator activity	KDM5B MID2 CALCOCO1 NSD1 KMT2C BRCA1 ING4 TRIM13	3.12e-03	562	87	8	GO:0003712
GeneOntologyMolecularFunction	histone H4 acetyltransferase activity	BRPF3 ING4	4.47e-03	23	87	2	GO:0010485
Domain	-	KDM5B BRPF3 RNF152 MID2 KDM5C NSD1 KDM5D RNF151 KMT2C NEURL3 BRCA1 LTN1 SHPRH ANKIB1 ING4 TRIM13 TOPORS PHF21B	3.24e-12	449	89	18	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM5B BRPF3 RNF152 MID2 KDM5C NSD1 KDM5D RNF151 KMT2C NEURL3 BRCA1 LTN1 SHPRH ANKIB1 ING4 TRIM13 TOPORS PHF21B	4.68e-12	459	89	18	IPR013083
Domain	NPIP	NPIPB15 NPIPB9 NPIPB3 NPIPB5 NPIPB2 NPIPB13	2.87e-11	14	89	6	IPR009443
Domain	PHD	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ING4 PHF21B	3.90e-10	89	89	9	SM00249
Domain	Znf_PHD	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ING4 PHF21B	4.77e-10	91	89	9	IPR001965
Domain	ZF_PHD_2	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ING4 PHF21B	7.04e-10	95	89	9	PS50016
Domain	ZF_PHD_1	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ING4 PHF21B	7.74e-10	96	89	9	PS01359
Domain	Znf_FYVE_PHD	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ANKIB1 ING4 PHF21B	2.00e-09	147	89	10	IPR011011
Domain	PHD	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C ING4 PHF21B	2.51e-09	75	89	8	PF00628
Domain	Znf_PHD-finger	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C ING4 PHF21B	3.82e-09	79	89	8	IPR019787
Domain	RING	RNF152 MID2 NSD1 RNF151 KMT2C NEURL3 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	2.24e-08	305	89	12	SM00184
Domain	Zinc_finger_PHD-type_CS	KDM5B BRPF3 KDM5C NSD1 KDM5D SHPRH ING4	2.44e-08	65	89	7	IPR019786
Domain	Znf_RING	RNF152 MID2 NSD1 RNF151 KMT2C NEURL3 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	4.66e-08	326	89	12	IPR001841
Domain	ZF_RING_2	RNF152 MID2 RNF151 KMT2C NEURL3 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	1.72e-07	298	89	11	PS50089
Domain	Lys_sp_deMease-like_dom	KDM5B KDM5C KDM5D	4.17e-07	4	89	3	IPR013637
Domain	PLU-1	KDM5B KDM5C KDM5D	4.17e-07	4	89	3	PF08429
Domain	FN3	MID2 KALRN CNTN6 MYBPHL IL2RB IL4R IL5RA SORL1 MYBPC3	4.50e-07	199	89	9	PS50853
Domain	FN3_dom	MID2 KALRN CNTN6 MYBPHL IL2RB IL4R IL5RA SORL1 MYBPC3	6.79e-07	209	89	9	IPR003961
Domain	zf-C5HC2	KDM5B KDM5C KDM5D	1.04e-06	5	89	3	PF02928
Domain	Znf_C5HC2	KDM5B KDM5C KDM5D	1.04e-06	5	89	3	IPR004198
Domain	FN3	MID2 KALRN CNTN6 MYBPHL IL2RB IL4R SORL1 MYBPC3	2.84e-06	185	89	8	SM00060
Domain	-	ADAMTSL1 MID2 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL IL2RB IL4R IL5RA SORL1 MYBPC3	2.87e-06	663	89	14	2.60.40.10
Domain	Ig_I-set	ADAMTSL1 KALRN FGFRL1 CNTN6 HEPACAM SIGLEC11 MYBPHL MYBPC3	3.46e-06	190	89	8	IPR013098
Domain	I-set	ADAMTSL1 KALRN FGFRL1 CNTN6 HEPACAM SIGLEC11 MYBPHL MYBPC3	3.46e-06	190	89	8	PF07679
Domain	Ig-like_fold	ADAMTSL1 MID2 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL IL2RB IL4R IL5RA SORL1 MYBPC3	5.91e-06	706	89	14	IPR013783
Domain	ZF_RING_1	RNF152 MID2 RNF151 BRCA1 LTN1 SHPRH ANKIB1 TRIM13 TOPORS	1.02e-05	291	89	9	PS00518
Domain	JmjN	KDM5B KDM5C KDM5D	1.23e-05	10	89	3	SM00545
Domain	JMJN	KDM5B KDM5C KDM5D	1.23e-05	10	89	3	PS51183
Domain	JmjN	KDM5B KDM5C KDM5D	1.23e-05	10	89	3	PF02375
Domain	JmjN	KDM5B KDM5C KDM5D	1.23e-05	10	89	3	IPR003349
Domain	IGc2	ADAMTSL1 KALRN FGFRL1 CNTN6 HEPACAM SIGLEC11 MYBPHL MYBPC3	1.64e-05	235	89	8	SM00408
Domain	Ig_sub2	ADAMTSL1 KALRN FGFRL1 CNTN6 HEPACAM SIGLEC11 MYBPHL MYBPC3	1.64e-05	235	89	8	IPR003598
Domain	-	KDM5B KDM5C KDM5D	4.57e-05	15	89	3	1.10.150.60
Domain	BRIGHT	KDM5B KDM5C KDM5D	4.57e-05	15	89	3	SM00501
Domain	ARID_dom	KDM5B KDM5C KDM5D	4.57e-05	15	89	3	IPR001606
Domain	ARID	KDM5B KDM5C KDM5D	4.57e-05	15	89	3	PS51011
Domain	ARID	KDM5B KDM5C KDM5D	4.57e-05	15	89	3	PF01388
Domain	zf-C3HC4	RNF152 MID2 RNF151 BRCA1 LTN1 TRIM13 TOPORS	9.46e-05	223	89	7	PF00097
Domain	fn3	MID2 KALRN CNTN6 MYBPHL SORL1 MYBPC3	1.25e-04	162	89	6	PF00041
Domain	Znf_RING_CS	MID2 RNF151 BRCA1 SHPRH TRIM13 TOPORS	1.29e-04	163	89	6	IPR017907
Domain	Golgin_A_7/ERF4	CHIC1 CHIC2	1.34e-04	4	89	2	IPR019383
Domain	Erf4	CHIC1 CHIC2	1.34e-04	4	89	2	PF10256
Domain	Znf_C3HC4_RING-type	RNF152 MID2 BRCA1 LTN1 TRIM13 TOPORS	1.73e-04	172	89	6	IPR018957
Domain	IG	ADAMTSL1 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL MYBPC3	1.78e-04	421	89	9	SM00409
Domain	Ig_sub	ADAMTSL1 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL MYBPC3	1.78e-04	421	89	9	IPR003599
Domain	JmjC	KDM5B KDM5C KDM5D	1.97e-04	24	89	3	PF02373
Domain	JMJC	KDM5B KDM5C KDM5D	4.69e-04	32	89	3	PS51184
Domain	JmjC_dom	KDM5B KDM5C KDM5D	4.69e-04	32	89	3	IPR003347
Domain	JmjC	KDM5B KDM5C KDM5D	5.15e-04	33	89	3	SM00558
Domain	IG_LIKE	ADAMTSL1 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL MYBPC3	5.50e-04	491	89	9	PS50835
Domain	HEMATOPO_REC_S_F1	IL2RB IL4R	6.17e-04	8	89	2	PS01355
Domain	Ig-like_dom	ADAMTSL1 KALRN FGFRL1 CNTN6 CD300C HEPACAM SIGLEC11 MYBPHL MYBPC3	6.53e-04	503	89	9	IPR007110
Domain	Hempt_rcpt_S_F1_CS	IL2RB IL4R	7.91e-04	9	89	2	IPR003531
Domain	Post-SET_dom	NSD1 KMT2C	2.58e-03	16	89	2	IPR003616
Domain	PostSET	NSD1 KMT2C	2.58e-03	16	89	2	SM00508
Domain	POST_SET	NSD1 KMT2C	2.58e-03	16	89	2	PS50868
Domain	UIM	ANKRD13A ANKIB1	3.27e-03	18	89	2	PF02809
Domain	DH_1	KALRN ARHGEF10L VAV2	3.38e-03	63	89	3	PS00741
Domain	C1	DGKZ KMT2C VAV2	3.69e-03	65	89	3	SM00109
Domain	PE/DAG-bd	DGKZ KMT2C VAV2	3.85e-03	66	89	3	IPR002219
Domain	PWWP	BRPF3 NSD1	4.03e-03	20	89	2	SM00293
Domain	RhoGEF	KALRN ARHGEF10L VAV2	4.19e-03	68	89	3	SM00325
Domain	UIM	ANKRD13A ANKIB1	4.45e-03	21	89	2	SM00726
Domain	RhoGEF	KALRN ARHGEF10L VAV2	4.55e-03	70	89	3	PF00621
Domain	DH_2	KALRN ARHGEF10L VAV2	4.55e-03	70	89	3	PS50010
Domain	DH-domain	KALRN ARHGEF10L VAV2	4.73e-03	71	89	3	IPR000219
Domain	-	KALRN ARHGEF10L VAV2	4.73e-03	71	89	3	1.20.900.10
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KDM5B BRPF3 KDM5C NSD1 KDM5D ING4	7.96e-05	175	58	6	MM14941
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C ING4	1.20e-04	272	58	7	M29619
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	NSD1 CNTN6 KMT2C BRCA1	1.45e-04	65	58	4	M39682
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM5B KDM5C KDM5D	2.24e-04	29	58	3	MM14934
Pathway	KEGG_MEDICUS_VARIANT_EWSR1_WT1_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	PDGFA IL2RB	2.47e-04	6	58	2	M47446
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	IL2RB IL4R IL5RA	2.48e-04	30	58	3	M39641
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	IL2RB IL4R IL5RA	2.48e-04	30	58	3	MM15812
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5B KDM5C KDM5D KMT2C	3.99e-08	13	97	4	24619213
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5B KDM5C KDM5D	8.40e-08	4	97	3	16541399
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5B KDM5C KDM5D	8.40e-08	4	97	3	17320160
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM5B KDM5C NSD1 KDM5D KMT2C	2.63e-07	49	97	5	34368113
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5B KDM5C NSD1 KDM5D KMT2C	5.68e-07	57	97	5	18022353
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF152 UBE2L6 MID2 BRCA1 LTN1 TOPORS	1.03e-06	118	97	6	19690564
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5B KDM5C NSD1 KDM5D	2.19e-06	33	97	4	26864203
Pubmed	Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs.	SNAI3 SNAI2	7.70e-06	2	97	2	26831822
Pubmed	A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.	CHIC1 CHIC2	7.70e-06	2	97	2	11257495
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	7.70e-06	2	97	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	7.70e-06	2	97	2	16416087
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	7.70e-06	2	97	2	32081420
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	7.70e-06	2	97	2	7524912
Pubmed	Alcohol-associated fibrosis in females is mediated by female-specific activation of lysine demethylases KDM5B and KDM5C.	KDM5B KDM5C	7.70e-06	2	97	2	35468265
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	7.70e-06	2	97	2	9060413
Pubmed	The snail superfamily of zinc-finger transcription factors.	SNAI3 SNAI2	2.31e-05	3	97	2	11994736
Pubmed	Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.	SNAI3 SNAI2	2.31e-05	3	97	2	24638100
Pubmed	Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.	SNAI3 SNAI2	2.31e-05	3	97	2	23874916
Pubmed	Investigation of genotype-phenotype relationship in Turkish patients with inherited retinal disease by next generation sequencing.	ABCA4 EYS	2.31e-05	3	97	2	34315337
Pubmed	Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting.	IL2RB IL4R	2.31e-05	3	97	2	21362618
Pubmed	Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.	KDM5B KDM5C	2.31e-05	3	97	2	38230606
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	2.31e-05	3	97	2	7544442
Pubmed	Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.	KDM5B KDM5C	2.31e-05	3	97	2	26645689
Pubmed	Structural analysis of human KDM5B guides histone demethylase inhibitor development.	KDM5B KDM5C	2.31e-05	3	97	2	27214403
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	2.31e-05	3	97	2	11948212
Pubmed	Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.	IL4R IL5RA	2.31e-05	3	97	2	16625214
Pubmed	Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells.	IL2RB IL4R IL5RA	2.70e-05	21	97	3	8499630
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM5B KDM5C KMT2C	2.70e-05	21	97	3	27626377
Pubmed	Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.	CFH CR1L	4.60e-05	4	97	2	27165610
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	4.60e-05	4	97	2	7951230
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	4.60e-05	4	97	2	32732223
Pubmed	Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.	SNAI3 SNAI2	4.60e-05	4	97	2	25732600
Pubmed	Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.	BRCA1 LTN1	7.66e-05	5	97	2	27977889
Pubmed	Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack.	CFH CR1L	7.66e-05	5	97	2	23390291
Pubmed	C3-dependent mechanism of microglial priming relevant to multiple sclerosis.	CFH CR1L	7.66e-05	5	97	2	22219359
Pubmed	p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.	SNAI3 SNAI2	7.66e-05	5	97	2	20385133
Pubmed	Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.	KMT2C BRCA1	7.66e-05	5	97	2	27653681
Pubmed	Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.	SLC24A4 SORL1	7.66e-05	5	97	2	25365775
Pubmed	The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.	CFH CR1L	7.66e-05	5	97	2	20675597
Pubmed	Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.	CFH CR1L	7.66e-05	5	97	2	20962256
Pubmed	Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.	ABCA4 CR1L	7.66e-05	5	97	2	28348233
Pubmed	Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages.	IL4R IL5RA	7.66e-05	5	97	2	18203142
Pubmed	MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.	KDM5B KDM5C	7.66e-05	5	97	2	26621457
Pubmed	Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.	KDM5B KDM5C	1.15e-04	6	97	2	21960634
Pubmed	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.	SNAI3 SNAI2	1.15e-04	6	97	2	14673164
Pubmed	Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.	IL2RB IL4R	1.15e-04	6	97	2	12133952
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NPIPB9 NPIPB11 NPIPB3 NPIPB2	1.21e-04	90	97	4	15616553
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	NPIPB7 NPIPB15 NPIPB4 IL4R	1.32e-04	92	97	4	10493829
Pubmed	Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.	IL2RB IL4R IL5RA	1.40e-04	36	97	3	20811626
Pubmed	Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.	CFH CR1L	1.60e-04	7	97	2	28057640
Pubmed	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	KDM5B KDM5C	1.60e-04	7	97	2	28262558
Pubmed	Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression.	BRCA1 SNAI2	1.60e-04	7	97	2	23011797
Pubmed	The regulation of the complement system: insights from genetically-engineered mice.	CFH CR1L	1.60e-04	7	97	2	12914820
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KDM5B MYOG NAIP SNAI3 KMT2C BRCA1 SNAI2 ING4 TRIM13	1.67e-04	709	97	9	22988430
Pubmed	IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.	IL2RB IL4R	2.13e-04	8	97	2	18714000
Pubmed	Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15.	APOBEC3D IL2RB	2.13e-04	8	97	2	10438878
Pubmed	Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway.	BRCA1 SNAI2	2.13e-04	8	97	2	35236825
Pubmed	Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos.	SNAI3 SNAI2	2.13e-04	8	97	2	29445069
Pubmed	Genetic organization of complement receptor-related genes in the mouse.	CFH CR1L	2.13e-04	8	97	2	2564419
Pubmed	Development and patterning of rib primordia are dependent on associated musculature.	PDGFA MYOG	2.13e-04	8	97	2	32768399
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	KDM5C FGFRL1 ANKRD13A LLGL1 LTN1 ANKIB1	2.52e-04	313	97	6	38270169
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM5B KDM5C KMT2C	2.56e-04	44	97	3	24183668
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KALRN NSD1 FGFRL1 ZNF395 REV3L ZNF865 ZBTB42 REPIN1 ARHGEF10L KMT2C IL4R	2.61e-04	1105	97	11	35748872
Pubmed	Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.	CFH CR1L	2.74e-04	9	97	2	18947875
Pubmed	The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex.	IL2RB IL4R	3.41e-04	10	97	2	12960323
Pubmed	Circulating AIM prevents hepatocellular carcinoma through complement activation.	CFH CR1L	3.41e-04	10	97	2	25284781
Pubmed	Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice.	CFH CR1L	3.41e-04	10	97	2	8422330
Pubmed	Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.	CFH CR1L	4.17e-04	11	97	2	23204401
Pubmed	Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development.	SNAI3 SNAI2	4.99e-04	12	97	2	21287656
Pubmed	Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite.	PDGFA MYOG	4.99e-04	12	97	2	10208749
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	REV3L BRCA1	4.99e-04	12	97	2	28700933
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KDM5B KMT2C	5.89e-04	13	97	2	21502505
Pubmed	Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.	UBE2L6 TRIM13	5.89e-04	13	97	2	37205848
Pubmed	CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation.	BRCA1 IL4R	5.89e-04	13	97	2	35657353
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	5.89e-04	13	97	2	14660691
Pubmed	Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny.	IL2RB IL4R	6.85e-04	14	97	2	9344502
Pubmed	Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.	IL2RB IL4R	6.85e-04	14	97	2	18715339
Pubmed	Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.	IL2RB IL4R	6.85e-04	14	97	2	17152005
Pubmed	Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains.	PDGFA MYOG	6.85e-04	14	97	2	20412779
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	CFH ABCA4	6.85e-04	14	97	2	19015224
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5C KDM5D	7.89e-04	15	97	2	14762062
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	LLGL1 BRCA1 ING4	8.10e-04	65	97	3	27453043
Pubmed	Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse.	PDGFA MYOG	9.01e-04	16	97	2	35225230
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	KDM5C CHIC1	1.02e-03	17	97	2	19571810
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BRPF3 KDM5C ADNP2 REV3L REPIN1 BRCA1 LTN1 ING4 TOPORS SORL1	1.12e-03	1116	97	10	31753913
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	MID2 TRIM13	1.14e-03	18	97	2	23077300
Pubmed	Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice.	DAND5 SNAI2	1.14e-03	18	97	2	16801545
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5C KDM5D	1.14e-03	18	97	2	12023983
Pubmed	Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.	PDGFA MYOG	1.14e-03	18	97	2	16387292
Pubmed	The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.	KDM5B KDM5C	1.42e-03	20	97	2	23637629
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	ABCA4 EYS TOPORS	1.53e-03	81	97	3	20301590
Pubmed	TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.	MID2 TRIM13	1.56e-03	21	97	2	18248090
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	BRPF3 ING4	1.56e-03	21	97	2	27270040
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	NPIPB4 NPIPB3 KDM5D	1.64e-03	83	97	3	9039502
Pubmed	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	BRCA1 IL4R	1.71e-03	22	97	2	18095154
Pubmed	Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration.	MYOG SNAI2	1.87e-03	23	97	2	23946446
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	CFH TNFRSF4	2.04e-03	24	97	2	11739537
Pubmed	High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.	KDM5B ADNP2 KMT2C	2.35e-03	94	97	3	16325481
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	APOBEC3D MUC19 SIGLEC11	2.42e-03	95	97	3	24029230
Pubmed	Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.	SNAI2 SORL1	2.58e-03	27	97	2	27178982
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB7 NPIPB4 NPIPB3 NPIPB5 IL4R	3.23e-05	172	96	5	chr16p12
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	6.54e-05	37	96	3	16p12.2
Cytoband	16p11.2	NPIPB7 NPIPB12 NPIPB11 NPIPB13	7.15e-04	191	96	4	16p11.2
GeneFamily	PHD finger proteins	KDM5B BRPF3 KDM5C NSD1 KDM5D KMT2C SHPRH ING4 PHF21B	2.74e-11	90	64	9	88
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 KALRN FGFRL1 CNTN6 SIGLEC11 MYBPHL MYBPC3	1.58e-06	161	64	7	593
GeneFamily	Ring finger proteins	RNF152 MID2 RNF151 BRCA1 LTN1 SHPRH TRIM13 TOPORS	5.48e-06	275	64	8	58
GeneFamily	AT-rich interaction domain containing	KDM5B KDM5C KDM5D	1.87e-05	15	64	3	418
GeneFamily	Fibronectin type III domain containing	MID2 KALRN CNTN6 MYBPHL SORL1 MYBPC3	2.15e-05	160	64	6	555
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM5C KDM5D	8.12e-05	24	64	3	485
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYBPHL MYBPC3	3.41e-04	8	64	2	658
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL2RB IL4R IL5RA	4.40e-04	42	64	3	602
GeneFamily	Zinc fingers C2H2-type\|SNAG transcriptional repressors	SNAI3 SNAI2	5.45e-04	10	64	2	1259
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KALRN ARHGEF10L VAV2	1.65e-03	66	64	3	722
GeneFamily	PWWP domain containing	BRPF3 NSD1	2.72e-03	22	64	2	1147
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ADNP2 ZNF395 ZNF865 ZBTB42 REPIN1 SNAI3 GLIS2 SNAI2	3.70e-03	718	64	8	28
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD1 KMT2C	6.43e-03	34	64	2	487
GeneFamily	Complement system\|Sushi domain containing	CFH CR1L	7.19e-03	36	64	2	492
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD300C TNFRSF4 IL2RB IL4R IL5RA	1.28e-02	394	64	5	471
GeneFamily	X-linked mental retardation\|Angiotensin receptors	MID2 KDM5C	1.51e-02	53	64	2	103
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CR1L	1.74e-02	57	64	2	1179
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5B KDM5C KDM5D	9.21e-08	4	85	3	DOID:0060809 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5B KDM5C KDM5D	1.26e-05	16	85	3	DOID:0050888 (implicated_via_orthology)
Disease	protein JTB measurement	CFH PIGT	2.46e-05	3	85	2	EFO_0802948
Disease	scavenger receptor class F member 2 measurement	CFH SCARF2	4.90e-05	4	85	2	EFO_0020716
Disease	probable ATP-dependent RNA helicase DDX58 measurement	CFH TOPORS	4.90e-05	4	85	2	EFO_0801913
Disease	cystatin-8 measurement	CFH CCL16	8.15e-05	5	85	2	EFO_0801509
Disease	NKG2-E type II integral membrane protein measurement	CFH CCL16	1.22e-04	6	85	2	EFO_0801842
Disease	Adenoid Cystic Carcinoma	NSD1 CNTN6 KMT2C BRCA1	2.04e-04	100	85	4	C0010606
Disease	Malignant neoplasm of breast	ABCA4 PDGFA KALRN SCARF2 XDH CNTN6 LLGL1 BRCA1 SNAI2 FASTKD3 SORL1	2.57e-04	1074	85	11	C0006142
Disease	acute graft vs. host disease, donor genotype effect measurement	KALRN EYS	8.40e-04	15	85	2	EFO_0004599, EFO_0007892
Disease	carcinoma (implicated_via_orthology)	SNAI3 LLGL1 SNAI2	8.47e-04	64	85	3	DOID:305 (implicated_via_orthology)
Disease	Rolandic epilepsy	PTCHD3 KALRN	9.59e-04	16	85	2	Orphanet_1945
Disease	Age-related macular degeneration	CFH ABCA4	1.22e-03	18	85	2	cv:C0242383
Disease	Retinitis pigmentosa	ABCA4 EYS TOPORS	1.29e-03	74	85	3	cv:C0035334
Disease	intellectual disability (implicated_via_orthology)	KDM5B KDM5C KDM5D	1.34e-03	75	85	3	DOID:1059 (implicated_via_orthology)
Disease	Leukemia, Myelocytic, Acute	NSD1 KMT2C CHIC2 BRCA1	1.60e-03	173	85	4	C0023467
Disease	cardiovascular system disease (is_implicated_in)	CFH XDH	1.66e-03	21	85	2	DOID:1287 (is_implicated_in)
Disease	initial pursuit acceleration	ARHGEF10L LTN1 CCL16	2.05e-03	87	85	3	EFO_0008434
Disease	stomach carcinoma (is_marker_for)	KMT2C BRCA1	2.17e-03	24	85	2	DOID:5517 (is_marker_for)
Disease	eye color	ITPKB EYS SLC24A4	2.26e-03	90	85	3	EFO_0003949
Disease	macular degeneration (is_implicated_in)	CFH ABCA4	2.75e-03	27	85	2	DOID:4448 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKIAFLWASGCCPLL	NAIP	481	Q13075
DKKSKAPFWCPILAC	ARHGEF10L	771	Q9HCE6
SLPFCSWKKAAAQRP	C9orf50	366	Q5SZB4
WNPCLPCVVKVTKFL	APOBEC3D	106	Q96AK3
WKAVAKPRLCAPAAE	CCDC187	41	A0A096LP49
KVPEWVNTPSTCCLK	CCL16	26	O15467
KQKWTQVNPSPSCRC	ABCA4	1476	P78363
CLPWALGCRKKTPKA	ATP13A3	1171	Q9H7F0
GRQLVPGWKLCPKCT	ARL14EP	106	Q8N8R7
IPPARWKLTCYICKQ	BRPF3	316	Q9ULD4
WLLTNSKPCANCKSP	ANKIB1	511	Q9P2G1
CRKGEWVALNPLRKC	CFH	66	P08603
WVALNPLRKCQKRPC	CFH	71	P08603
CIWIIFLLPPPCKKC	PKD1L1-AS1	6	Q9H7B7
KQWKTCPVCNELFPS	ADNP2	691	Q6IQ32
TLNKFWCRPPQILRC	CD300C	51	Q08708
LLCVTIPNCSKPRWE	SLC24A4	436	Q8NFF2
CKIPPSARKALCNWV	NPIPB3	201	Q92617
CLNLTKRPAGKWECP	NSD1	2146	Q96L73
CKIPPSARKALCNWV	NPIPB12	201	F8W0I5
FPCKAINKILWRNCE	LLGL1	286	Q15334
CIPALLGWTKKDLCS	LTN1	1146	O94822
CLVRVFWPKAKCALL	MFN1	156	Q8IWA4
CPNDVCRIWKSGAKL	ANKRD13A	141	Q8IZ07
PLVLCNSCMPARKRW	DAND5	141	Q8N907
TPLKRAGWQCPECKV	KMT2C	376	Q8NEZ4
KPCVSLLFWKRGICP	EYS	296	Q5T1H1
PKLAQDCWLCLKAKP	ERVS71-1	296	P61550
WRCPKCILAECKQPP	KDM5D	356	Q9BY66
QLLKSCNLDPCPARW	ADAMTSL1	656	Q8N6G6
LWLCQAQKKPCTPAP	FGFRL1	396	Q8N441
VCVSWRKPNLCPVYC	MUC19	1526	Q7Z5P9
QCKVCGRPKPTITWK	KALRN	2491	O60229
CKIPPSARKALCNWV	NPIPB5	201	A8MRT5
VPKGDWRCPKCLAQE	KDM5B	346	Q9UGL1
WRCPKCLAQECSKPQ	KDM5B	351	Q9UGL1
DLPLPKQLVCRWAKC	GLIS2	161	Q9BZE0
CKIPPSARKPLCNWV	NPIPB7	201	O75200
CKIPPSARKALCNWV	NPIPB4	201	C9JG80
VLSKGPLICWKECRS	GREB1L	226	Q9C091
CKIPPSARKPLCNWV	NPIPB15	201	A6NHN6
CKIPPSARKALCNWV	NPIPB11	201	E5RHQ5
PLCERKEWNKQKLPC	BRCA1	346	P38398
PAKCPHWKNCLTKLL	IL4R	296	P24394
ICKICHLWIKLFPPI	IL5RA	361	Q01344
ACLKVWGRSCIKLVP	FBXO9	236	Q9UK97
KCQALNKWEPELPSC	CR1L	271	Q2VPA4
NCRNTGPWLKKVLKC	IL2RB	266	P14784
KKNLPVNVRWLLCGC	CHIC2	76	Q9UKJ5
CKPNAFPRAAISWKR	CNTN6	431	Q9UQ52
FCCVRASPRPKIIWL	MYBPHL	281	A2RUH7
LVTVCACWKPSKRKQ	HEPACAM	256	Q14CZ8
KCIKRRPPWQICSKF	CEP57L1	251	Q8IYX8
PTCQKLSPKWCFLDA	DGKZ	706	Q13574
KALPVNVKWLLCGCL	CHIC1	136	Q5VXU3
PTWKECPICKERFPA	CALCOCO1	651	Q9P1Z2
CKIPPSARKPLCNWV	NPIPB9	216	F8W1W9
TKPRGKWFCPRCSQE	ING4	231	Q9UNL4
VVCLCWLKKADPKWP	PTCHD3	546	Q3KNS1
CKIPPSARKALCNWV	NPIPB13	201	A6NJU9
PPRFCFQSKSWKRCV	PIF1	356	Q9H611
FECHQPKTCIPNWKR	SORL1	1476	Q92673
QKDVRCPWCRGVTKL	RNF152	46	Q8N8N0
KKCILRWLARQKTCP	RNF151	41	Q2KHN1
NCFNAKCWKPRPLSI	TMEM225B	56	P0DP42
PWFCFKPKKLPCSSR	NXPE3	246	Q969Y0
CWDAAKDLKEPQCPP	ITPKB	481	P27987
VVKERLCPWLCSRQP	FASTKD3	36	Q14CZ7
VCKICGKAFSRPWLL	SNAI2	186	O43623
PCPICARQLGKQWAV	SHPRH	1431	Q149N8
AKRPIACPKCERRFW	REPIN1	141	Q9BWE0
TWPKRVAQLPLKACL	SLC6A18	356	Q96N87
CKICGKAFSRPWLLQ	SNAI3	211	Q3KNW1
ACPLCWKVFKKPSHL	ZNF865	351	P0CJ78
LWRPAPFKCPTCRKE	TRIM13	46	O60858
NFLIWPPCVEVKRCT	PDGFA	116	P04085
APKGVWVCPRCQQKA	PHF21B	386	Q96EK2
VCTENLTPWKKLLPC	PIGT	181	Q969N2
PCKCAPSRQLVQVWL	REV3L	1996	O60673
TKCPRQFWGPDCKEL	SCARF2	111	Q96GP6
KVGWLQCCRIEKRPL	PSTK	331	Q8IV42
CLPIISSENWKPCTK	UBE2L6	86	O14933
KCLWPNCGKVLRSIV	ZNF395	281	Q9H8N7
LTKCEWCNVRKLPVV	SENP6	491	Q9GZR1
WHLKPTICKQPCILL	SENP6	961	Q9GZR1
ENCWKKRGLCIIPTK	XDH	991	P47989
AICPRGKQWLCFTKI	ERVH48-1	101	M5A8F1
CKIPPSARKALCNWV	NPIPB2	216	A6NJ64
KCPVCRWQIEAVAPA	NEURL3	236	Q96EH8
VSSKPCKPCTWCNLR	TNFRSF4	76	P43489
WTADLCPAARKAKLP	ZBTB42	146	B2RXF5
WSKNKAECPLCKQPF	TOPORS	131	Q9NS56
QCGRWLIDCKVLPPN	VAV2	6	P52735
GLWPEIRKCKEAVSC	MID2	456	Q9UJV3
CSSCWLVPRKNVQPK	ZGLP1	241	P0C6A0
LNPSPKVTHCCKSLW	PXT1	16	Q8NFP0
ICVFNWAFKKCPAPS	SIGLEC11	176	Q96RL6
WRCPKCVMAECKRPP	KDM5C	366	P41229
LPWACKVCKRKSVSV	MYOG	66	P15173
CCAVRGSPKPKISWF	MYBPC3	1201	Q14896