Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-24	7.75e-14	37	93	9	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-24	1.01e-13	38	93	9	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.88e-10	11	93	5	GO:0004523
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	1.36e-09	431	93	15	GO:0004984
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.81e-09	14	93	5	GO:0003964
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR52Z1P OR7G2 GNRHR OR6K6 OR8U9	2.02e-08	884	93	19	GO:0004930
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.77e-08	21	93	5	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	7.62e-07	37	93	5	GO:0016891
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 CD27 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR52Z1P OR7G2 GNRHR OR6K6 CHRNB4 OR8U9	8.02e-07	1353	93	21	GO:0004888
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.74e-07	38	93	5	GO:0034061
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 AGO1 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.83e-06	79	93	6	GO:0004521
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.32e-06	46	93	5	GO:0016893
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 AGO1 ERI3 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.39e-06	136	93	7	GO:0004540
GeneOntologyMolecularFunction	structural molecule activity	TINAGL1 ERVK-6 CLTCL1 KRT82 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 NEB ERVK-24 MUC2	1.48e-05	891	93	15	GO:0005198
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 AGO1 ERVK-8 ERVK-7 ERVK-10 ERVK-11	4.19e-05	136	93	6	GO:0004519
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 AGO1 ERI3 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.03e-04	231	93	7	GO:0004518
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-24	1.78e-04	430	93	9	GO:0004175
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4A KDM4E	3.18e-04	6	93	2	GO:0140684
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERVK-6 ENPP7 PDE4A AGO1 PLCH2 BCKDK ERI3 ERVK-8 HDDC2 ERVK-7 ERVK-10 ERVK-11	3.61e-04	807	93	12	GO:0016788
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	7.26e-04	152	93	5	GO:0016779
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 DDX17 AGO1 ERI3 ERVK-8 ERVK-7 ERVK-10 ERVK-11	7.33e-04	417	93	8	GO:0140098
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 ENPP7 TADA2B ERVK-8 ERVK-5 ERVK-19 KDM4A ERVK-7 ERVK-9 ERVK-10 ERVK-24 ERVK-11	8.67e-04	891	93	12	GO:0008270
GeneOntologyMolecularFunction	peptidase activity	TINAGL1 ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-24	9.29e-04	654	93	10	GO:0008233
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERCC2 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.42e-03	262	93	6	GO:0140097
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4A KDM4E	1.88e-03	14	93	2	GO:0032454
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 ERCC2 DDX17 AGO1 ERI3 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.12e-03	645	93	9	GO:0140640
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH3 DNAH17	3.13e-03	18	93	2	GO:0008569
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 ENPP7 TADA2B ERVK-8 ERVK-5 ERVK-19 KDM4A ERVK-7 ERVK-9 ERVK-10 ERVK-24 ERVK-11 MUC2	3.39e-03	1189	93	13	GO:0046914
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T3 OR10D3 OR51G2 OR6V1 PDE4A OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	1.90e-10	465	91	16	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	6.60e-10	432	91	15	GO:0050911
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.87e-09	13	91	5	GO:0015074
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T3 OR10D3 OR51G2 OR6V1 PDE4A OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	2.00e-09	547	91	16	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	3.19e-09	485	91	15	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 ATP2B2 OR6K6 OR8U9	4.84e-09	582	91	16	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	9.03e-09	524	91	15	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OTOP1 OR4D11 OR52Z1P OR7G2 ATP2B2 OR6K6 OR8U9	1.51e-08	722	91	17	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2T3 OR10D3 OR51G2 OR6V1 PDE4A OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 PLCH2 HCAR1 OR4D1 OR4D11 TACR3 OR52Z1P OR7G2 GNRHR OR6K6 OR8U9	5.31e-07	1395	91	21	GO:0007186
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.21e-06	48	91	5	GO:0000731
GeneOntologyBiologicalProcess	sensory perception	OR2T3 OR10D3 OR51G2 OR6V1 PDE4A OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 ATP2B2 OR6K6 OR8U9	3.90e-06	1072	91	17	GO:0007600
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.31e-05	83	91	5	GO:0006278
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 ERVK-8 TOPBP1 ERVK-7 ERVK-10 ERVK-11	1.38e-04	178	91	6	GO:0006261
GeneOntologyBiologicalProcess	viral process	ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 EIF2AK4 ERVK-9 ERVK-10 ERVK-24	2.09e-04	464	91	9	GO:0016032
GeneOntologyBiologicalProcess	DNA recombination	ERVK-6 ERCC2 ERVK-8 TOPBP1 ERVK-7 ERVK-10 KDM4E ERVK-11	2.23e-04	368	91	8	GO:0006310
GeneOntologyBiologicalProcess	DNA damage response	ERVK-6 ERCC2 PPP2R5C BCL2L11 RPTOR TADA2B ERVK-8 TOPBP1 ERVK-7 EIF2AK4 ERVK-10 KDM4E ERVK-11	2.90e-04	959	91	13	GO:0006974
GeneOntologyBiologicalProcess	positive regulation of odontoblast differentiation	IPO7 RPTOR	3.99e-04	7	91	2	GO:1901331
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 EGF ERVK-8 ERVK-7 ERVK-10 ERVK-11	4.11e-04	218	91	6	GO:0071897
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 ENPP7 ERVK-8 TOPBP1 ERVK-7 ERVK-10 ERVK-11	4.63e-04	312	91	7	GO:0006260
GeneOntologyBiologicalProcess	positive regulation of neuroepithelial cell differentiation	IPO7 RPTOR	5.30e-04	8	91	2	GO:1902913
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-9	5.46e-04	85	91	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-9	5.46e-04	85	91	4	GO:0000768
GeneOntologyCellularComponent	CAK-ERCC2 complex	CCNH ERCC2	1.14e-04	4	92	2	GO:0070516
Domain	GPCR_Rhodpsn_7TM	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR7G2 GNRHR OR6K6 OR8U9	2.72e-09	670	80	17	IPR017452
Domain	7tm_1	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR7G2 GNRHR OR6K6 OR8U9	3.17e-09	677	80	17	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR7G2 GNRHR OR6K6 OR8U9	3.79e-09	685	80	17	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR7G2 GNRHR OR6K6 OR8U9	4.31e-09	691	80	17	PS50262
Domain	GPCR_Rhodpsn	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 CYSLTR1 HCAR1 OR4D1 OR4D11 TACR3 OR7G2 GNRHR OR6K6 OR8U9	4.41e-09	692	80	17	IPR000276
Domain	Olfact_rcpt	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR7G2 OR6K6 OR8U9	1.15e-08	393	80	13	IPR000725
Domain	JmjN	KDM4A KDM4E	7.97e-04	10	80	2	SM00545
Domain	RWD	EIF2AK4 WDR59	7.97e-04	10	80	2	PS50908
Domain	JMJN	KDM4A KDM4E	7.97e-04	10	80	2	PS51183
Domain	JmjN	KDM4A KDM4E	7.97e-04	10	80	2	PF02375
Domain	JmjN	KDM4A KDM4E	7.97e-04	10	80	2	IPR003349
Domain	RWD	EIF2AK4 WDR59	9.72e-04	11	80	2	SM00591
Domain	RWD-domain	EIF2AK4 WDR59	1.16e-03	12	80	2	IPR006575
Domain	RNaseH-like_dom	ERVK-6 AGO1 ERI3	3.24e-03	69	80	3	IPR012337
Domain	zf-CCHC	ERVK-6 ERVK-5	4.32e-03	23	80	2	PF00098
Domain	HDc	PDE4A HDDC2	4.70e-03	24	80	2	SM00471
Domain	HD/PDEase_dom	PDE4A HDDC2	4.70e-03	24	80	2	IPR003607
Domain	JmjC	KDM4A KDM4E	4.70e-03	24	80	2	PF02373
Domain	JMJC	KDM4A KDM4E	8.27e-03	32	80	2	PS51184
Domain	JmjC_dom	KDM4A KDM4E	8.27e-03	32	80	2	IPR003347
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OTOP1 OR4D11 APOB OR52Z1P OR7G2 ATP2B2 OR6K6 OR8U9	2.00e-09	636	72	18	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T3 OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6 OR8U9	2.24e-09	417	72	15	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR7G2 OR6K6	5.67e-07	389	72	12	M14091
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-7 ERVK-25 ERVK-9 ERVK-10 ERVK-24 ERVK-11	1.56e-15	94	93	11	21542922
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-25 ERVK-9 ERVK-10 ERVK-24 ERVK-11	5.61e-12	18	93	6	18664271
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	4.79e-11	4	93	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-5 ERVK-19 ERVK-10	4.79e-11	4	93	4	7983737
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR10D3 OR51G2 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6	1.42e-10	343	93	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR10D3 OR51G2 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6	1.57e-10	346	93	12	14611657
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-18 ERVK-19 ERVK-7	2.39e-10	5	93	4	12629516
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR10D3 OR51G2 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2	1.98e-09	340	93	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR10D3 OR51G2 OR10J5 OR2A12 OR2M7 OR8U1 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2	1.98e-09	340	93	11	11802173
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	1.85e-08	3	93	3	10516026
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9 ERVK-11	1.85e-08	3	93	3	9971820
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-9	2.33e-08	12	93	4	14557543
Pubmed	The human olfactory receptor gene family.	OR10D3 OR51G2 OR6V1 OR10J5 OR2A12 OR2M7 OR4D10 OR4D1 OR4D11 OR52Z1P OR7G2 OR6K6	2.36e-08	541	93	12	14983052
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-5 ERVK-7	1.84e-07	5	93	3	11401426
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	3.68e-07	6	93	3	15063128
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	NCOA2 OSTC FAT1 ERCC2 CLTCL1 BCL2L11 ETV1 SRP72 KDM4A EIF2AK4 ERVK-25 ERVK-10 MAST2 RPUSD1 CHRNB4	7.87e-07	1215	93	15	15146197
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	NTNG2 PLCH2 BTG1 APBA1 ETV1 CHRNB4	5.84e-06	166	93	6	19906978
Pubmed	General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.	BCKDK EIF2AK4	7.07e-06	2	93	2	24019515
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	7.07e-06	2	93	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	7.07e-06	2	93	2	9460924
Pubmed	Association of EGF rs4444903 and XPD rs13181 polymorphisms with cutaneous melanoma in Caucasians.	ERCC2 EGF	7.07e-06	2	93	2	25537294
Pubmed	Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism.	TACR3 GNRHR	7.07e-06	2	93	2	22766261
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	7.07e-06	2	93	2	11672541
Pubmed	The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.	KDM4A KDM4E	2.12e-05	3	93	2	21555854
Pubmed	Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.	ETV1 KDM4A	2.12e-05	3	93	2	26731476
Pubmed	Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses.	ERVK-24 ERVK-11	2.12e-05	3	93	2	22067224
Pubmed	Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.	NCOA2 EGF	2.12e-05	3	93	2	14662770
Pubmed	High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk.	CCNH ERCC2	4.23e-05	4	93	2	17728339
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4A KDM4E	7.04e-05	5	93	2	16738407
Pubmed	Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.	CCNH ERCC2	7.04e-05	5	93	2	10024882
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4A KDM4E	7.04e-05	5	93	2	21914792
Pubmed	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.	BCL2L11 RPTOR	1.05e-04	6	93	2	27601261
Pubmed	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome.	RPTOR ETV1	1.05e-04	6	93	2	27845329
Pubmed	p44/SSL1, the regulatory subunit of the XPD/RAD3 helicase, plays a crucial role in the transcriptional activity of TFIIH.	CCNH ERCC2	1.05e-04	6	93	2	10924514
Pubmed	Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk.	CCNH ERCC2	1.47e-04	7	93	2	16492920
Pubmed	Nucleotide excision repair pathway genes and oral premalignant lesions.	CCNH ERCC2	1.47e-04	7	93	2	17575242
Pubmed	Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.	CCNH ERCC2	1.47e-04	7	93	2	11062469
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TINAGL1 FAT1 ERCC2 PDE4A CLTCL1 BCL2L11 RPTOR UCKL1 MAST2 ANKRD33B WDR59	1.79e-04	1105	93	11	35748872
Pubmed	Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway.	CCNH ERCC2	1.96e-04	8	93	2	19270000
Pubmed	Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.	CCNH ERCC2	1.96e-04	8	93	2	9118947
Pubmed	Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics.	EGF APOB	1.96e-04	8	93	2	23631828
Pubmed	Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.	NCOA2 ETV1	1.96e-04	8	93	2	14747462
Pubmed	The diploid genome sequence of an individual human.	OR8U1 OR8U9	1.96e-04	8	93	2	17803354
Pubmed	Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.	CCNH ERCC2	2.52e-04	9	93	2	9130708
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2A12 OR4D10 OR4D1 OR4D11 OR7G2	3.13e-04	219	93	5	12213199
Pubmed	Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.	CCNH ERCC2	3.14e-04	10	93	2	8692841
Pubmed	A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.	CCNH ERCC2	3.14e-04	10	93	2	15220921
Pubmed	Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.	CCNH ERCC2	3.14e-04	10	93	2	26340423
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19	3.14e-04	10	93	2	12970426
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4A KDM4E	3.83e-04	11	93	2	19144645
Pubmed	Population differences in the human functional olfactory repertoire.	OR2A12 OR4D10	3.83e-04	11	93	2	12644552
Pubmed	Three functional classes of transcriptional activation domain.	CCNH ERCC2	3.83e-04	11	93	2	8628270
Pubmed	Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase.	CCNH ERCC2	3.83e-04	11	93	2	10082552
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	EGF APOB SLC40A1	4.39e-04	55	93	3	10926756
Pubmed	Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.	ERCC2 EGF	4.59e-04	12	93	2	16407418
Pubmed	Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.	CCNH ERCC2	4.59e-04	12	93	2	8692842
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA2 KDM4A KDM4E	4.88e-04	57	93	3	18022353
Pubmed	Szt2, a novel gene for seizure threshold in mice.	KDM4A CFAP57	5.41e-04	13	93	2	19624305
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DNAH17	6.30e-04	14	93	2	9373155
Pubmed	Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons.	ETV1 SLC12A5	6.30e-04	14	93	2	23142661
Pubmed	Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis.	NTNG2 ETV1	6.30e-04	14	93	2	32433957
Pubmed	A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.	OSTC EGF TACR3	6.85e-04	64	93	3	20332099
Pubmed	Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.	CCNH ERCC2	7.26e-04	15	93	2	18854777
Pubmed	Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.	OR10J5 OR6K6	8.28e-04	16	93	2	25437545
Pubmed	Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.	CCNH ERCC2	8.28e-04	16	93	2	11313499
Pubmed	Chromosomal location-dependent nonstochastic onset of odor receptor expression.	OR10J5 OR7G2	9.37e-04	17	93	2	20668191
Pubmed	Natural selection on the olfactory receptor gene family in humans and chimpanzees.	OR51G2 OR10J5	9.37e-04	17	93	2	12908129
Pubmed	Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.	KLHL13 TOPBP1	1.05e-03	18	93	2	19084217
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	ERVK-6 ERVK-10 ANKRD33B	1.09e-03	75	93	3	15372022
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	ERCC2 EGF CYSLTR1 GNRHR	1.15e-03	170	93	4	19064572
Pubmed	Rrn3 becomes inactivated in the process of ribosomal DNA transcription.	CCNH ERCC2	1.17e-03	19	93	2	12646563
Pubmed	Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.	ETV1 MAST2	1.17e-03	19	93	2	30449657
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	RPTOR WDR59	1.30e-03	20	93	2	28199306
Pubmed	DNA damage recognition during nucleotide excision repair in mammalian cells.	CCNH ERCC2	1.30e-03	20	93	2	10214908
Pubmed	Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.	CCNH ERCC2	1.44e-03	21	93	2	9852112
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4A KDM4E	1.44e-03	21	93	2	27626377
Pubmed	The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.	CCNH ERCC2	1.44e-03	21	93	2	9334327
Pubmed	Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.	CCNH ERCC2	1.58e-03	22	93	2	9582279
Pubmed	Transcriptional control: Tat cofactors and transcriptional elongation.	CCNH ERCC2	1.73e-03	23	93	2	9651670
Pubmed	Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation.	CCNH ERCC2	1.73e-03	23	93	2	10438593
Pubmed	Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.	CCNH ERCC2	1.73e-03	23	93	2	10866664
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	CCNH ERCC2	1.73e-03	23	93	2	12393749
Pubmed	A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.	CCNH ERCC2	1.73e-03	23	93	2	9311822
Pubmed	Tat, Tat-associated kinase, and transcription.	CCNH ERCC2	1.73e-03	23	93	2	9570510
Pubmed	The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.	CCNH ERCC2	1.88e-03	24	93	2	14569024
Pubmed	Hierarchical organization of cortical and thalamic connectivity.	NTNG2 ETV1	1.88e-03	24	93	2	31666704
Pubmed	Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.	CCNH ERCC2	1.88e-03	24	93	2	10066804
Pubmed	Proteomics analysis of the estrogen receptor alpha receptosome.	NCOA2 DDX17 TOPBP1	2.02e-03	93	93	3	20348541
Pubmed	Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.	CCNH ERCC2	2.04e-03	25	93	2	9184228
Pubmed	Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.	CCNH ERCC2	2.04e-03	25	93	2	8934526
Pubmed	Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.	CCNH ERCC2	2.04e-03	25	93	2	9512541
Pubmed	Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.	CCNH ERCC2	2.04e-03	25	93	2	9790902
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	CYSLTR1 TACR3 GNRHR	2.14e-03	95	93	3	16754659
Pubmed	Regulation of archicortical arealization by the transcription factor Zbtb20.	ETV1 TACR3	2.56e-03	28	93	2	22689450
Pubmed	Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	TACR3 GNRHR	2.56e-03	28	93	2	20301509
Pubmed	Quality control by DNA repair.	CCNH ERCC2	2.56e-03	28	93	2	10583946
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	AGO1 ERI3 KDM4A CFAP57 MAST2	3.25e-04	294	92	5	chr1p34
Cytoband	4q25	OSTC EGF TACR3	3.40e-04	67	92	3	4q25
Cytoband	17q25.3	ENPP7 RPTOR DNAH17	1.13e-03	101	92	3	17q25.3
Cytoband	11q12.1	OR8U1 OR4D10 OR4D11	4.23e-03	161	92	3	11q12.1
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	BCL2L11 PLXDC1 CYSLTR1 PLCH2 BTG1 NEB	6.16e-07	167	81	6	c0c944eae0514dc8e00d0c2892a0792e157695ec
Disease	lung non-small cell carcinoma (is_implicated_in)	NCOA2 FAT1 ERCC2 EGF CHRNB4	2.51e-05	139	73	5	DOID:3908 (is_implicated_in)
Disease	gallbladder cancer (is_implicated_in)	EGF APOB	4.63e-04	13	73	2	DOID:3121 (is_implicated_in)
Disease	Hypogonadotropic hypogonadism	TACR3 GNRHR	6.21e-04	15	73	2	C0271623
Disease	Primary hypogonadism	TACR3 GNRHR	6.21e-04	15	73	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	TACR3 GNRHR	6.21e-04	15	73	2	C3489396
Disease	Hypogonadism	TACR3 GNRHR	7.08e-04	16	73	2	C0020619
Disease	Idiopathic hypogonadotropic hypogonadism	TACR3 GNRHR	9.00e-04	18	73	2	C0342384
Disease	Glioblastoma	CCNH FAT1 EGF	1.00e-03	79	73	3	C0017636
Disease	reticulocyte count	FAT1 EGF BCL2L11 DNAH17 ZNF217 EIF2AK4 SIPA1 MAST2 SLC12A5	1.08e-03	1045	73	9	EFO_0007986
Disease	serum homoarginine measurement	TINAGL1 ANKRD33B	1.11e-03	20	73	2	EFO_0005421
Disease	Giant Cell Glioblastoma	CCNH FAT1 EGF	1.20e-03	84	73	3	C0334588
Disease	Colorectal Carcinoma	DNAH3 FAT1 ERCC2 ETV1 APOB ZNF217 SLC12A5	1.75e-03	702	73	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
YDHTEIDMVLMTPTA	CHRNB4	176	P30926
RTMEIESTFHMYVQP	ERI3	176	O43414
FTYHMVSGMSLRPRV	ERVK-18	81	O42043
VSPISRFTYHMVSGM	ERVK-19	186	O71037
VSPISRFTYHMVSGM	ERVK-8	186	Q902F8
SPICRFTYHMVSGMS	ERVK-9	186	Q9UKH3
FTYHMVSGMSLRPRV	ERVK-9	191	Q9UKH3
VMEYHPRIIMLTCAF	CCNH	96	P51946
PYVSEMLEARTAGHM	CD27	146	P26842
IIFFEMSYHPMVTAS	EIF2AK4	931	Q9P2K8
MSYHPMVTASERIFV	EIF2AK4	936	Q9P2K8
YEGFAMPHSIMRVDI	ACTR1B	171	P42025
DVAMRHLASMRYTPV	AGO1	161	Q9UL18
HYLSAMASMRQAEPA	BCL2L11	126	O43521
IYPEVVHMFAVNMFR	PPP2R5C	91	Q13362
MRATMESHLDTPYNV	BCKDK	281	O14874
PSEHYTIIFNTFVMM	ATP2B2	991	Q01814
DHMVRMTTSLYSPAV	ANKRD33B	306	A6NCL7
HMPSAMTVYALVVVS	OSTC	26	Q9NRP0
MTERSLHEPMYLFLS	OR52Z1P	36	P0C646
TMRLRTYSTHAVVMY	FAT1	3856	Q14517
HFEAPAVESMPMSVY	FAT1	4526	Q14517
MVTVTCESRLHTPMY	OR4D11	46	Q8NGI4
TPMYVFLSHLAIVDM	OR2A12	56	Q8NGT7
TYTAIVISHSGRMMF	CFAP57	596	Q96MR6
TDMMPLLHNYVTVDT	IPO7	691	O95373
MSIYSFPMDEPISSH	MAPK6	316	Q16659
HSPMQDKMVSVFYTI	OR2M7	266	Q8NG81
TERSLHEPMYLFLSM	OR51G2	56	Q8NGK0
RPSSYHIMVSMAIGV	MUC2	486	Q02817
PVDTMVTYMLTLEDH	PDE4A	411	P27815
DTVPLSHFDESMAYM	ETV1	446	P50549
SARIMTFYPTMEEFR	KDM4A	11	O75164
TSHTIMTFYPTMEEF	KDM4E	11	B2RXH2
LDFHPVTMATFTMTL	ERCC2	471	P18074
SFSSYSAVMPRMVTH	KRT82	16	Q9NSB4
SAVMPRMVTHYAVSK	KRT82	21	Q9NSB4
LPSSYHTAEQDMMVS	OR2T3	266	Q8NH03
VSYMFIISAILRMHS	OR8U9	216	P0C7N5
VSPISRFTYHMVSGM	ERVK-7	946	P63135
MVIADTHLHTPMYFF	OR6V1	46	Q8N148
VVNLAMPFSIFYRMH	OTOP1	586	Q7RTM1
MPFSIFYRMHAAASL	OTOP1	591	Q7RTM1
FRSVMAPFTMTIDAH	APOB	1896	P04114
PVHRVMMASASDYFK	KLHL13	106	Q9P2N7
YAPAFMMVVISLDRS	GNRHR	126	P30968
MSYVHTTVNEMSRVY	DNAH17	2991	Q9UFH2
VMSHSFYPPLMQRTS	DNAH3	76	Q8TD57
SPISRFTYHMVSGMS	ERVK-24	76	P61566
FTYHMVSGMSLRPRV	ERVK-24	81	P61566
VSPISRFTYHMVSGM	ERVK-25	186	P61570
VSPICRFTYHMVSGM	ERVK-6	186	Q69384
SPISRFTYHMVSGMS	ERVK-7	76	P61567
FTYHMVSGMSLRPRV	ERVK-7	81	P61567
MERSFHMPSYGTQTL	EGF	1161	P01133
VMERYTSAVSMVKPH	COQ10A	141	Q96MF6
MRISTMTSHDYALPV	HYAL4	286	Q2M3T9
TMMDHPLRTISYIAD	APBA1	536	Q02410
FTYHMVSGMSLRPRV	ERVK-5	81	Q9HDB8
PVSFDSEIIMMNHVY	MAST2	306	Q6P0Q8
QRPESVSDHMYRMAV	HDDC2	41	Q7Z4H3
HITLSFTYMNSMLDP	HCAR1	261	Q9BXC0
VSPISRFTYHMVSGM	HERVK_113	186	Q902F9
YVMDVLMDQHFTEPT	DDX17	181	Q92841
HFRETVLEPISGYMM	CCDC168	2046	Q8NDH2
YMTPAFVTMTSPCHF	ENPP7	66	Q6UWV6
VPMMLQSSTISYLHD	SERPINA6	231	P08185
YVIPSLAHRFMAEMV	FAM8A1	241	Q9UBU6
MVTVTFDCRLHTPMY	OR4D1	46	Q15615
LVAVMSSARLHTPMY	OR10D3	46	Q8NH80
TPIDMDHPYVFSDMT	SLC12A5	406	Q9H2X9
MVTEFLFSMFPHAHR	OR6K6	36	Q8NGW6
HTPMYFFLSMLASSE	OR10J5	56	Q8NHC4
MVTVTCESRLHTPMY	OR4D10	46	Q8NGI6
DVVMTFEYGRPTVMV	NTNG2	136	Q96CW9
VSYMFIISAILRMHS	OR8U1	216	Q8NH10
MMLHAFYLRIPTDTE	RPUSD1	206	Q9UJJ7
IRPSSSVMNMHEIYT	TINAGL1	181	Q9GZM7
RTPQEVMEHYVSMYI	TADA2B	101	Q86TJ2
TAVASVMYSVFPQMV	OR7G2	271	Q8NG99
DHEIMFHVSTMLPYT	SIPA1	401	Q96FS4
ISVSFVAMGHIMYFR	SLC40A1	526	Q9NP59
PGMVSALVTMYSHEE	SRP72	406	O76094
YTVTRMESMTVVFDP	TACR3	401	P29371
VLADPYMPAEHRTMT	RPTOR	521	Q8N122
YMPAEHRTMTAFILA	RPTOR	526	Q8N122
CHMFAPSDYRTMIIS	SVOPL	336	Q8N434
MHPFYTRAATMIGEI	BTG1	1	P62324
YDNAVLTMMSHPTEA	CLTCL1	1371	P53675
MVVTAAFLVSFMPYH	CYSLTR1	236	Q9Y271
FHTMGQRPSYATLRM	NCOA2	1156	Q15596
SSIYPEDLMQIVSHM	RASGEF1A	231	Q8N9B8
RTLAFSSMMPGYRHV	PLCH2	851	O75038
PMTNYTTVRREFMDH	SULT1A2	236	P50226
VSPISRFTYHMVSGM	ERVK-10	946	P10266
VSPICRFTYHMVSGM	ERVK-11	946	Q9UQG0
VYFTRPMTMHRAVSP	WDR59	551	Q6PJI9
MAEMGVHSVAYAFPR	UCKL1	486	Q9NWZ5
TFKTFYPEVLMMHQR	ZNF217	716	O75362
HRMLTATQYVAPLMA	PLXDC1	166	Q8IUK5
RSIHYPPETASIMLM	SMYD5	156	Q6GMV2
RAEHPVYNMVMSDVT	TOPBP1	96	Q92547
VIHTYNMLPDAMSFE	NEB	1896	P20929