Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2 RYR3

3.41e-074893GO:0005219
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 RYR3 ITPR1

1.08e-0618894GO:0015278
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2 RYR3

1.70e-066893GO:0048763
GeneOntologyMolecularFunctioncalcium channel activity

TRPM6 STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

1.77e-06129897GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM6 STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

5.05e-06151897GO:0015085
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR2 RYR3 ITPR1

1.06e-0531894GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 RYR3 ITPR1

1.37e-0533894GO:0005217
GeneOntologyMolecularFunctionprotein-membrane adaptor activity

AKAP6 SPTBN4 SYNE1 SLC4A1

4.78e-0545894GO:0043495
GeneOntologyMolecularFunctionL27 domain binding

LIN7C LIN7A

1.17e-044892GO:0097016
GeneOntologyMolecularFunctionankyrin binding

SPTBN4 SPTB SLC4A1

1.42e-0423893GO:0030506
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC39A4 SLC4A3 SLC4A1

3.87e-0432893GO:0015106
GeneOntologyMolecularFunctionspectrin binding

SPTBN4 SPTAN1 EPB41L2

4.63e-0434893GO:0030507
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

TRPM6 STIM1 APOL3 SLC39A4 ORAI2 SLC4A3 RYR1 RYR2 RYR3 SLC4A1 ITPR1

5.41e-047588911GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TRPM6 STIM1 APOL3 SLC39A4 ORAI2 SLC4A3 RYR1 RYR2 RYR3 SLC4A1 ITPR1

7.85e-047938911GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPM6 STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

8.57e-04343897GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPM6 STIM1 APOL3 ORAI2 RYR1 RYR2 RYR3 ITPR1

1.02e-03459898GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPM6 STIM1 SLC39A4 ORAI2 RYR1 RYR2 RYR3 ITPR1

1.11e-03465898GO:0046873
GeneOntologyMolecularFunctionstore-operated calcium channel activity

STIM1 ORAI2

1.26e-0312892GO:0015279
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A3 SLC4A1

1.48e-0313892GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A3 SLC4A1

1.48e-0313892GO:0140829
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

PLCL2 ITPR1

1.73e-0314892GO:0070679
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NADP+) activity

RDH11 RDH10

1.99e-0315892GO:0052650
GeneOntologyMolecularFunctionchannel activity

TRPM6 STIM1 APOL3 ORAI2 RYR1 RYR2 RYR3 ITPR1

2.37e-03525898GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TRPM6 STIM1 APOL3 ORAI2 RYR1 RYR2 RYR3 ITPR1

2.40e-03526898GO:0022803
GeneOntologyMolecularFunctioncytoskeletal protein binding

STIM1 ROCK2 SPTBN4 CCDC88C LIN7C SYNE1 SPTAN1 SPTB NFKB1 MAST1 EPB41L2 SLC4A1

3.43e-0310998912GO:0008092
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

RYR1 RYR2 RYR3 ITPR1

3.57e-03140894GO:0099094
GeneOntologyMolecularFunctioncalmodulin binding

PHKB SPTAN1 RYR1 RYR2 RYR3

3.68e-03230895GO:0005516
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

AKAP6 RYR1 RYR2 RYR3 ITPR1

6.85e-0739895GO:1903514
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2 RYR3

1.25e-0511893GO:0071313
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

AKAP6 RYR1 RYR2 RYR3

1.92e-0537894GO:0014808
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2 RYR3

2.73e-0514893GO:0071415
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

AKAP6 RYR1 RYR2 RYR3

3.85e-0544894GO:0070296
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

AKAP6 RYR1 RYR2 RYR3 ITPR1 CEMIP

4.07e-05146896GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

AKAP6 RYR1 RYR2 RYR3 ITPR1 CEMIP

4.23e-05147896GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

AKAP6 RYR1 RYR2 RYR3 ITPR1 CEMIP

4.56e-05149896GO:0051282
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

AKAP6 TRPM6 STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1 CEMIP

4.91e-05392899GO:0070588
GeneOntologyBiologicalProcesssequestering of calcium ion

AKAP6 RYR1 RYR2 RYR3 ITPR1 CEMIP

5.28e-05153896GO:0051208
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

AKAP6 STIM1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

6.34e-056118911GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

AKAP6 STIM1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

7.44e-056228911GO:0006873
GeneOntologyBiologicalProcessresponse to caffeine

RYR1 RYR2 RYR3

9.76e-0521893GO:0031000
GeneOntologyBiologicalProcessregulation of actin filament-based process

AKAP6 ROCK2 SPTBN4 PPFIA1 SPTAN1 SPTB TSC1 RYR2 ARF1

1.15e-04438899GO:0032970
GeneOntologyBiologicalProcessprotein tetramerization

TRPM6 TDO2 RYR1 RYR3 ITPR1

1.30e-04113895GO:0051262
GeneOntologyBiologicalProcessmaintenance of location in cell

AKAP6 SYNE1 RYR1 RYR2 RYR3 ITPR1 CEMIP

1.30e-04259897GO:0051651
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

AKAP6 STIM1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

2.23e-047058911GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

AKAP6 STIM1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

2.57e-047178911GO:0050801
GeneOntologyBiologicalProcessmaintenance of location

AKAP6 SYNE1 NFKB1 RYR1 RYR2 RYR3 ITPR1 CEMIP

3.13e-04396898GO:0051235
GeneOntologyBiologicalProcessregulation of actin filament organization

ROCK2 SPTBN4 PPFIA1 SPTAN1 SPTB TSC1 ARF1

3.20e-04300897GO:0110053
GeneOntologyBiologicalProcessprotein homotetramerization

TDO2 RYR1 RYR3 ITPR1

3.45e-0477894GO:0051289
GeneOntologyBiologicalProcessmetal ion transport

AKAP6 TRPM6 STIM1 SPTBN4 SLC39A4 TSC1 ORAI2 RYR1 RYR2 ARF1 RYR3 ITPR1 CEMIP

3.47e-0410008913GO:0030001
GeneOntologyBiologicalProcesscalcium ion transport

AKAP6 TRPM6 STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1 CEMIP

3.49e-04509899GO:0006816
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

AKAP6 RYR1 RYR2 RYR3 ITPR1 CEMIP

3.56e-04217896GO:0097553
GeneOntologyBiologicalProcessB cell receptor signaling pathway

NFKB1 PLCL2 PRKCH SOS1

3.80e-0479894GO:0050853
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

AKAP6 TRPM6 STIM1 SLC39A4 ORAI2 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

4.08e-0410178913GO:0098660
GeneOntologyBiologicalProcessprotein localization to cell periphery

ROCK2 SPTBN4 LIN7C PPFIA1 PRKCH EPB41L2 SLC4A1 LIN7A

4.78e-04422898GO:1990778
GeneOntologyBiologicalProcessprotein localization to basolateral plasma membrane

LIN7C LIN7A

5.07e-048892GO:1903361
GeneOntologyBiologicalProcessactin filament-based process

AKAP6 ROCK2 SPTBN4 CCDC88C PPFIA1 SPTAN1 SPTB TSC1 THSD7B EPB41L2 RYR2 ARF1

5.37e-049128912GO:0030029
GeneOntologyBiologicalProcesspositive regulation of calcium ion transport

AKAP6 STIM1 RYR2 ITPR1 CEMIP

5.45e-04154895GO:0051928
GeneOntologyBiologicalProcessbicarbonate transport

SLC39A4 SLC4A3 SLC4A1

5.87e-0438893GO:0015701
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

SPTBN4 CCDC88C SPTAN1 SPTB

5.98e-0489894GO:1901880
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

ROCK2 SPTBN4 CCDC88C PPFIA1 SPTAN1 SPTB TSC1 ARF1

6.10e-04438898GO:1902903
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transporter activity

AKAP6 STIM1 RYR2

6.34e-0439893GO:1901021
GeneOntologyBiologicalProcessregulation of dendritic spine development

PPFIA2 ITSN1 EIF4G2 ARF1

6.50e-0491894GO:0060998
GeneOntologyBiologicalProcesscellular response to alkaloid

RYR1 RYR2 RYR3

6.84e-0440893GO:0071312
GeneOntologyBiologicalProcesssynapse organization

ROCK2 SPTBN4 PPFIA4 PPFIA2 PPFIA1 ITSN1 SPTB LRRTM4 TSC1 ARF1

7.32e-046858910GO:0050808
GeneOntologyBiologicalProcessmonoatomic ion transport

AKAP6 TRPM6 STIM1 SPTBN4 SLC39A4 TSC1 ORAI2 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

7.48e-0413748915GO:0006811
GeneOntologyBiologicalProcessresponse to purine-containing compound

AKAP6 RYR1 RYR2 RYR3 ITPR1

7.65e-04166895GO:0014074
GeneOntologyBiologicalProcessnegative regulation of retinoic acid receptor signaling pathway

CYP26C1 PRAME

8.10e-0410892GO:0048387
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

AKAP6 STIM1 RYR1 RYR2 RYR3 ITPR1 CEMIP

9.26e-04359897GO:0006874
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

SPTBN4 CCDC88C SPTAN1 SPTB

9.26e-04100894GO:0043242
GeneOntologyBiologicalProcesspositive regulation of cation transmembrane transport

AKAP6 STIM1 RYR2 ARF1 CEMIP

9.45e-04174895GO:1904064
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

AKAP6 TRPM6 STIM1 SLC39A4 ORAI2 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1 ITPR1 CEMIP

9.62e-0411158913GO:0034220
GeneOntologyBiologicalProcessmaintenance of epithelial cell apical/basal polarity

LIN7C LIN7A

9.87e-0411892GO:0045199
GeneOntologyBiologicalProcessresponse to decreased oxygen levels

ROCK2 MTHFR ANGPTL4 TSC1 RYR1 RYR2 ITPR1

1.00e-03364897GO:0036293
GeneOntologyBiologicalProcessactin filament capping

SPTBN4 SPTAN1 SPTB

1.03e-0346893GO:0051693
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transport

AKAP6 STIM1 RYR2 ARF1 ITPR1 CEMIP

1.03e-03266896GO:0043270
GeneOntologyCellularComponentspectrin

SPTBN4 SPTAN1 SPTB EPB41L2

3.64e-089884GO:0008091
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

AKAP6 STIM1 RYR1 RYR2 RYR3

1.26e-0645885GO:0033017
GeneOntologyCellularComponentsarcoplasmic reticulum

AKAP6 STIM1 RYR1 RYR2 RYR3 ITPR1

1.92e-0688886GO:0016529
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

AKAP6 RYR1 RYR2

8.47e-0610883GO:0014701
GeneOntologyCellularComponentsarcoplasm

AKAP6 STIM1 RYR1 RYR2 RYR3 ITPR1

8.68e-06114886GO:0016528
GeneOntologyCellularComponentcell cortex

STIM1 SPTBN4 NRBP1 SPTAN1 SPTB TSC1 EPB41L2 RYR1 SLC4A1

2.64e-05371889GO:0005938
GeneOntologyCellularComponentsmooth endoplasmic reticulum

RYR1 RYR2 RYR3 ITPR1

4.18e-0546884GO:0005790
GeneOntologyCellularComponentanchoring junction

AKAP6 SPTBN4 DOCK5 CCDC88C LIN7C PPFIA1 SPTAN1 EIF4G2 PRKCH PCDH12 EPB41L2 ARF1 SLC4A1 LIN7A

5.45e-059768814GO:0070161
GeneOntologyCellularComponentpostsynapse

ROCK2 LIN7C SYNE1 PPFIA2 PPFIA1 SPTAN1 ITSN1 SPTB LRRTM4 EIF4G2 TSC1 ARF1 LIN7A ITPR1

8.56e-0510188814GO:0098794
GeneOntologyCellularComponentsarcomere

SYNE1 SPTAN1 RYR1 RYR2 ARF1 RYR3 SLC4A1

8.74e-05249887GO:0030017
GeneOntologyCellularComponentmyofibril

SYNE1 SPTAN1 RYR1 RYR2 ARF1 RYR3 SLC4A1

1.55e-04273887GO:0030016
GeneOntologyCellularComponentMPP7-DLG1-LIN7 complex

LIN7C LIN7A

1.74e-045882GO:0097025
GeneOntologyCellularComponentcell-cell junction

AKAP6 SPTBN4 CCDC88C LIN7C SPTAN1 EIF4G2 PRKCH PCDH12 SLC4A1 LIN7A

1.88e-045918810GO:0005911
GeneOntologyCellularComponentintercalated disc

AKAP6 SPTBN4 SPTAN1 SLC4A1

1.94e-0468884GO:0014704
GeneOntologyCellularComponentcortical cytoskeleton

SPTBN4 SPTAN1 SPTB EPB41L2 SLC4A1

2.15e-04129885GO:0030863
GeneOntologyCellularComponentcontractile muscle fiber

SYNE1 SPTAN1 RYR1 RYR2 ARF1 RYR3 SLC4A1

2.24e-04290887GO:0043292
GeneOntologyCellularComponentcalcium channel complex

AKAP6 RYR1 RYR2 RYR3

2.56e-0473884GO:0034704
GeneOntologyCellularComponentpostsynaptic specialization

ROCK2 LIN7C PPFIA2 LRRTM4 EIF4G2 TSC1 ARF1 LIN7A ITPR1

2.67e-04503889GO:0099572
GeneOntologyCellularComponentZ disc

SPTAN1 RYR1 RYR2 RYR3 SLC4A1

4.45e-04151885GO:0030018
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

6.19e-049882GO:0030314
GeneOntologyCellularComponentpostsynaptic density

ROCK2 LIN7C LRRTM4 EIF4G2 TSC1 ARF1 LIN7A ITPR1

6.28e-04451888GO:0014069
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTBN4 SPTAN1 SPTB EPB41L2

6.43e-0493884GO:0030864
GeneOntologyCellularComponentcell-cell contact zone

AKAP6 SPTBN4 SPTAN1 SLC4A1

6.70e-0494884GO:0044291
GeneOntologyCellularComponentI band

SPTAN1 RYR1 RYR2 RYR3 SLC4A1

6.85e-04166885GO:0031674
GeneOntologyCellularComponentasymmetric synapse

ROCK2 LIN7C LRRTM4 EIF4G2 TSC1 ARF1 LIN7A ITPR1

9.03e-04477888GO:0032279
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

SPTB RYR1 RYR2 RYR3 SLC4A1

1.11e-03185885GO:0009898
GeneOntologyCellularComponentneuron to neuron synapse

ROCK2 LIN7C LRRTM4 EIF4G2 TSC1 ARF1 LIN7A ITPR1

1.62e-03523888GO:0098984
GeneOntologyCellularComponentspecific granule lumen

SPTAN1 NFKB1 QPCT

2.28e-0362883GO:0035580
GeneOntologyCellularComponentparanode region of axon

SPTBN4 SPTAN1

2.29e-0317882GO:0033270
GeneOntologyCellularComponentnuclear envelope

AKAP6 SYNE1 ITSN1 NUP88 TNKS2 RYR2 ITPR1 CEMIP

2.48e-03560888GO:0005635
GeneOntologyCellularComponentcytoplasmic side of membrane

SPTB RYR1 RYR2 RYR3 SLC4A1

2.88e-03230885GO:0098562
GeneOntologyCellularComponentpresynaptic active zone

ROCK2 PPFIA4 PPFIA2 PPFIA1

2.98e-03141884GO:0048786
GeneOntologyCellularComponentaxon

STIM1 SPTBN4 PPFIA2 PPFIA1 SPTAN1 ITSN1 EIF4G2 MAST1 TSC1 ORAI2

4.20e-038918810GO:0030424
DomainRIH_assoc

RYR1 RYR2 RYR3 ITPR1

8.21e-096924PF08454
DomainRIH_assoc-dom

RYR1 RYR2 RYR3 ITPR1

8.21e-096924IPR013662
DomainRIH_dom

RYR1 RYR2 RYR3 ITPR1

8.21e-096924IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 RYR3 ITPR1

8.21e-096924IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 RYR3 ITPR1

8.21e-096924IPR015925
Domain-

RYR1 RYR2 RYR3 ITPR1

8.21e-0969241.25.10.30
DomainRYDR_ITPR

RYR1 RYR2 RYR3 ITPR1

8.21e-096924PF01365
DomainIns145_P3_rec

RYR1 RYR2 RYR3 ITPR1

8.21e-096924PF08709
DomainMIR

RYR1 RYR2 RYR3 ITPR1

1.13e-0710924PS50919
DomainMIR

RYR1 RYR2 RYR3 ITPR1

1.13e-0710924PF02815
DomainMIR

RYR1 RYR2 RYR3 ITPR1

1.13e-0710924SM00472
DomainMIR_motif

RYR1 RYR2 RYR3 ITPR1

1.13e-0710924IPR016093
DomainRyanrecept_TM4-6

RYR1 RYR2 RYR3

1.16e-073923IPR009460
DomainRyR

RYR1 RYR2 RYR3

1.16e-073923PF02026
DomainRyanodine_rcpt

RYR1 RYR2 RYR3

1.16e-073923IPR003032
DomainRR_TM4-6

RYR1 RYR2 RYR3

1.16e-073923PF06459
DomainRyan_recept

RYR1 RYR2 RYR3

1.16e-073923IPR013333
DomainSpectrin/alpha-actinin

AKAP6 SPTBN4 SYNE1 SPTAN1 SPTB

4.71e-0732925IPR018159
DomainSPEC

AKAP6 SPTBN4 SYNE1 SPTAN1 SPTB

4.71e-0732925SM00150
DomainSAM_2

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

2.16e-0643925PF07647
DomainLiprin

PPFIA4 PPFIA2 PPFIA1

2.29e-066923IPR029515
DomainSpectrin

SPTBN4 SYNE1 SPTAN1 SPTB

4.54e-0623924PF00435
DomainSpectrin_repeat

SPTBN4 SYNE1 SPTAN1 SPTB

1.19e-0529924IPR002017
DomainAnion_exchange_CS

SLC4A3 SLC4A1

7.18e-053922IPR018241
DomainSAM

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

7.38e-0588925SM00454
DomainAnk_2

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

9.30e-05215927PF12796
DomainSAM_DOMAIN

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

1.06e-0495925PS50105
DomainSAM

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

1.17e-0497925IPR001660
DomainAnk

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

1.34e-04228927PF00023
DomainSpectrin_bsu

SPTBN4 SPTB

1.43e-044922IPR016343
Domain-

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

1.78e-041069251.10.150.50
DomainActinin_actin-bd_CS

SPTBN4 SYNE1 SPTB

1.91e-0423923IPR001589
DomainACTININ_2

SPTBN4 SYNE1 SPTB

1.91e-0423923PS00020
DomainACTININ_1

SPTBN4 SYNE1 SPTB

1.91e-0423923PS00019
Domain-

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.24e-042489271.25.40.20
DomainAnion_exchange

SLC4A3 SLC4A1

2.38e-045922IPR001717
DomainANK

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.42e-04251927SM00248
DomainIon_trans_dom

TRPM6 RYR1 RYR2 RYR3 ITPR1

2.50e-04114925IPR005821
DomainIon_trans

TRPM6 RYR1 RYR2 RYR3 ITPR1

2.50e-04114925PF00520
DomainANK_REPEAT

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.54e-04253927PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.60e-04254927IPR020683
DomainANK_REP_REGION

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.60e-04254927PS50297
DomainSAM/pointed

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

2.82e-04117925IPR013761
DomainAnkyrin_rpt

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

3.13e-04262927IPR002110
DomainANION_EXCHANGER_2

SLC4A3 SLC4A1

4.96e-047922PS00220
DomainANION_EXCHANGER_1

SLC4A3 SLC4A1

4.96e-047922PS00219
DomainBand3_cytoplasmic_dom

SLC4A3 SLC4A1

8.45e-049922IPR013769
DomainBand_3_cyto

SLC4A3 SLC4A1

8.45e-049922PF07565
Domain-

SLC4A3 SLC4A1

8.45e-0499223.40.1100.10
DomainEF_hand_dom

STIM1 SPTAN1 ITSN1 RYR1 RYR2 RYR3

1.01e-03232926IPR002048
DomainL27_C

LIN7C LIN7A

1.05e-0310922IPR014775
DomainHCO3_cotransp

SLC4A3 SLC4A1

1.05e-0310922PF00955
DomainHCO3_transpt_C

SLC4A3 SLC4A1

1.05e-0310922IPR011531
DomainL27

LIN7C LIN7A

1.05e-0310922PF02828
DomainPTrfase/Anion_transptr

SLC4A3 SLC4A1

1.05e-0310922IPR016152
DomainHCO3_transpt_euk

SLC4A3 SLC4A1

1.05e-0310922IPR003020
DomainPkinase_C

ROCK2 MAST1 PRKCH

1.16e-0342923PF00433
DomainARM-type_fold

DOCK5 IFT172 EIF4G2 PSMD1 ARMH3 RYR3 ITPR1

1.43e-03339927IPR016024
DomainL27

LIN7C LIN7A

1.81e-0313922SM00569
DomainL27

LIN7C LIN7A

1.81e-0313922PS51022
DomainL27_dom

LIN7C LIN7A

1.81e-0313922IPR004172
Domain-

SPTAN1 ITSN1 PLCL2 RYR1 RYR2 RYR3

1.84e-032619261.10.238.10
DomainAGC-kinase_C

ROCK2 MAST1 PRKCH

2.65e-0356923IPR000961
DomainAGC_KINASE_CTER

ROCK2 MAST1 PRKCH

2.65e-0356923PS51285
DomainS_TK_X

ROCK2 MAST1 PRKCH

2.65e-0356923SM00133
DomainEF-hand-dom_pair

SPTAN1 ITSN1 PLCL2 RYR1 RYR2 RYR3

2.95e-03287926IPR011992
DomainCH

SPTBN4 SYNE1 SPTB

4.05e-0365923SM00033
DomainSAM_1

PPFIA4 PPFIA2 PPFIA1

4.60e-0368923PF00536
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

LIN7C PPFIA4 PPFIA2 PPFIA1 LIN7A

9.46e-0823725MM14852
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

LIN7C PPFIA4 PPFIA2 PPFIA1 LIN7A

9.46e-0823725M12627
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

LIN7C PPFIA4 PPFIA2 PPFIA1 LRRTM4 EPB41L2 LIN7A

2.84e-0787727M27617
PathwayREACTOME_ION_HOMEOSTASIS

STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

3.06e-0754726M27460
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR2 RYR3 ITPR1

4.32e-0713724M39589
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 RYR3 ITPR1

2.29e-0619724M47760
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

LIN7C PPFIA4 PPFIA2 PPFIA1 LIN7A

5.91e-0651725MM14499
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

LIN7C PPFIA4 PPFIA2 PPFIA1 LIN7A

5.91e-0651725M4281
PathwayREACTOME_ION_HOMEOSTASIS

STIM1 RYR1 RYR2 RYR3 ITPR1

7.86e-0654725MM15202
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTAN1 SPTB

1.49e-0510723MM15112
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR2 RYR3

2.05e-0511723M47958
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

STIM1 CUL1 NFKB1 PSMD1 ORAI2 ITPR1 SOS1

2.14e-05166727M608
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

PPFIA4 PPFIA2 PPFIA1 LRRTM4 EPB41L2

2.28e-0567725MM15327
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTAN1 SPTB SOS1

4.05e-0538724MM14969
PathwayREACTOME_CARDIAC_CONDUCTION

STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

5.20e-05130726M27454
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

STIM1 CUL1 NFKB1 PSMD1 ITPR1 SOS1

5.43e-05131726MM15717
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

STIM1 ORAI2 ITPR1

6.82e-0516723M26945
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

8.25e-0517723M93
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

8.25e-0517723MM14907
PathwayWP_TCELL_ACTIVATION_SARSCOV2

IL12B NFKB1 TSC1 ITPR1 SOS1

8.51e-0588725M42580
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

9.87e-0518723MM14702
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

9.87e-0518723MM14703
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

9.87e-0518723M27043
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

9.87e-0518723M13015
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

NFKB1 PRKCH RYR1 RYR2 RYR3 ITPR1

1.33e-04154726MM15974
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA2 PPFIA1

1.37e-0420723M27290
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA2 PPFIA1

1.37e-0420723MM14991
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

NFKB1 PRKCH RYR1 RYR2 RYR3 ITPR1

1.43e-04156726M39475
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTAN1 SPTB ARF1 ARF3

1.71e-04102725M27648
PathwayREACTOME_CARDIAC_CONDUCTION

STIM1 RYR1 RYR2 RYR3 ITPR1

1.79e-04103725MM15196
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

RDH11 CYP26C1 RDH10

1.83e-0422723M27445
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

LIN7C LRRTM4 EPB41L2 LIN7A

1.88e-0456724M27616
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

2.39e-0424723MM14834
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

2.39e-0424723M630
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTAN1 SPTB ARF1 ARF3

2.44e-04110725MM15350
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_STORE_OPERATED_CA2_CHANNEL

STIM1 ORAI2

2.55e-045722M49017
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTAN1 SPTB SOS1

2.97e-0463724M11187
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

RDH11 CYP26C1 RDH10

3.82e-0428723MM15188
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

STIM1 ORAI2 ITPR1

3.82e-0428723M924
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTAN1 SPTB

5.18e-0431723M877
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

STIM1 NFKB1 RYR1 ITPR1

5.50e-0474724M48080
PathwayREACTOME_MUSCLE_CONTRACTION

STIM1 ORAI2 RYR1 RYR2 RYR3 ITPR1

5.87e-04203726M5485
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

IL12B NFKB1 ITPR1

6.24e-0433723M39745
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM6 CUL1 ANGPTL4 PSMD1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1

6.32e-046817211MM14985
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

STIM1 CUL1 PAG1 ASB6 NFKB1 PSMD1 UBE3C KIR2DL3 ORAI2 ARF1 ITPR1 SOS1

9.17e-048287212M1058
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

PRKCH RYR1 RYR2 RYR3 ITPR1

9.19e-04147725MM15854
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

STIM1 ORAI2 ITPR1 SOS1

9.69e-0486724M601
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

STIM1 CUL1 PAG1 ASB6 NFKB1 PSMD1 UBE3C KIR2DL3 ARF1 ITPR1 SOS1

9.89e-047197211MM14540
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

PRKCH RYR1 RYR2 RYR3 ITPR1

1.04e-03151725M39329
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A1

1.13e-0310722M27335
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A1

1.13e-0310722MM15073
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM6 CUL1 ANGPTL4 PSMD1 SLC39A4 SLC4A3 RYR1 RYR2 ARF1 RYR3 SLC4A1

1.20e-037367211M27287
PathwayREACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT

SPTBN4 SPTAN1 SPTB ARF1 ARF3

1.20e-03156725M27097
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

RDH11 CYP26C1 RDH10

1.36e-0343723M27443
PathwayREACTOME_MUSCLE_CONTRACTION

STIM1 RYR1 RYR2 RYR3 ITPR1

1.54e-03165725MM15026
PathwayREACTOME_NEURONAL_SYSTEM

LIN7C PPFIA4 PPFIA2 PPFIA1 LRRTM4 EPB41L2 LIN7A

1.58e-03335727MM14503
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM6 RYR1 RYR2 RYR3

1.63e-0399724MM14910
PathwayWP_15Q25_COPY_NUMBER_VARIATION

RYR1 RYR2 ITPR1

1.66e-0346723M48105
PathwayREACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT

SPTBN4 SPTAN1 SPTB ARF1 ARF3

1.66e-03168725MM14785
PathwayREACTOME_CLEC7A_DECTIN_1_SIGNALING

CUL1 NFKB1 PSMD1 ITPR1

1.70e-03100724M27467
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2 RYR3 ITPR1

4.79e-11493423413940
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2 RYR3 ITPR1

4.79e-1149349607712
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 RYR3 ITPR1

7.16e-10693423463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 RYR3 ITPR1

7.16e-10693425966694
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 RYR3 ITPR1

7.16e-10693420519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 RYR3 ITPR1

7.16e-10693416844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 RYR3 ITPR1

1.67e-09793411860456
Pubmed

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

STIM1 ORAI2 RYR1 RYR3

3.33e-09893430563862
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A4P ANKRD20A3P ANKRD20A8P ANKRD20A1

3.33e-09893412634303
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 SPTBN4 NRBP1 NAA25 VPS45 IFT172 SYNE1 SPTAN1 ITSN1 SPTB EIF4G2 LRRCC1 MAST1 PSMD1 TNKS2 SLC4A3 RYR3 SOS1

7.72e-091285931835914814
Pubmed

Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.

LIN7C PPFIA4 PPFIA2 PPFIA1 LIN7A

1.66e-083093516186258
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2 RYR3

1.85e-08393318403125
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2 RYR3

1.85e-0839337876312
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2 RYR3

1.85e-08393322948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2 RYR3

1.85e-08393310788707
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2 RYR3

1.85e-0839337621815
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2 RYR3

1.85e-08393310473538
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2 RYR3

1.85e-08393318434746
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2 RYR3

1.85e-0839339204703
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2 RYR3

1.85e-08393321881589
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2 RYR3

1.85e-08393312213830
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2 RYR3

1.85e-0839339242641
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.85e-08393325239916
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2 RYR3

1.85e-08393318643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2 RYR3

1.85e-08393311159936
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR1 RYR2 ITPR1

1.85e-0839339986730
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2 RYR3

1.85e-0839337959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2 RYR3

1.85e-0839334600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2 RYR3

1.85e-0839337635066
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN4 SPTAN1 SPTB EPB41L2

3.36e-081393418796539
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 RYR2 ITPR1

7.39e-08493319120137
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2 RYR3

7.39e-08493323482488
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2 RYR3

7.39e-08493318206662
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2 RYR3

7.39e-0849339384575
Pubmed

Intracellular calcium-release channels: regulators of cell life and death.

RYR1 RYR2 ITPR1

1.84e-0759339124414
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2 RYR3

1.84e-07593323918386
Pubmed

The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.

PPFIA4 PPFIA2 PPFIA1

1.84e-07593319013515
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.84e-07593319011160
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ROCK2 SPTBN4 PHKB VPS45 PPFIA4 SYNE1 PPFIA2 PPFIA1 SPTAN1 ITSN1 SPTB EIF4G2 LRRCC1 MAST1 TSC1 EPB41L2 SLC4A1

2.25e-071431931737142655
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2 RYR3

3.68e-07693319549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2 RYR3

3.68e-07693326025922
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2 RYR3

3.68e-07693314592808
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2 RYR3

3.68e-07693319009018
Pubmed

Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins.

PPFIA4 PPFIA2 PPFIA1

3.68e-07693321618221
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTBN4 SPTAN1 SPTB SOS1

5.80e-07259348493579
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR1 RYR2 RYR3

6.43e-07793320962236
Pubmed

Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

6.43e-07793311931740
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2 RYR3

1.03e-06893311784029
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 RYR3

1.03e-06893319033399
Pubmed

Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

1.54e-06993312629171
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

STIM1 ORAI2 ITPR1

1.54e-06993325737585
Pubmed

Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.

PPFIA4 PPFIA2 PPFIA1

1.54e-06993312923177
Pubmed

Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.

PPFIA2 PPFIA1 LIN7A

2.19e-061093318054859
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CCDC88C PHKB VPS45 ITSN1 NFKB1 EIF4G2 NUP88 LRRCC1 TSC1 UBE3C ARF1 ARF3

2.96e-06853931228718761
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTBN4 SPTAN1 SPTB

3.01e-061193317607528
Pubmed

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

IL12B NFKB1 TSC1

3.01e-061193319169254
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR1 RYR2 RYR3 ITPR1

3.30e-063893430786075
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

AKAP6 ZNF17 SYNE1 PPFIA2 SPTAN1 SOS1

3.39e-0615193617043677
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR1 RYR2 RYR3

4.00e-061293319095005
Pubmed

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PPFIA4 PPFIA2 PPFIA1

4.00e-06129339624153
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

SPTBN4 PHKB LIN7C SPTAN1 EPB41L2 ITPR1

5.26e-0616393616512683
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

AKAP6 TRPM6 PHKB TICRR PANK3 PPFIA1 ITSN1 PLCL2 EIF4G2 ZBTB40 PSMD1 LRRC18 ITPR1

6.30e-061084931311544199
Pubmed

Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.

KIR2DL2 KIR2DL3

7.07e-06293225359276
Pubmed

Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population.

KIR2DL2 KIR2DL3

7.07e-06293226423800
Pubmed

Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

ARF1 ARF3

7.07e-0629322474826
Pubmed

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.

KIR2DL2 KIR2DL3

7.07e-06293233846289
Pubmed

Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population.

KIR2DL2 KIR2DL3

7.07e-06293220875478
Pubmed

Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.

RYR1 RYR3

7.07e-0629329489997
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

7.07e-06293217259277
Pubmed

The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.

RYR1 RYR3

7.07e-06293212640042
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

7.07e-06293214722100
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

7.07e-06293226009179
Pubmed

Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.

RYR1 ITPR1

7.07e-06293212654335
Pubmed

Variations in both α-spectrin (SPTA1) and β-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.

SPTAN1 SPTB

7.07e-06293224193021
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

7.07e-06293232899693
Pubmed

Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.

RYR1 RYR3

7.07e-06293214592949
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

7.07e-0629328898078
Pubmed

Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals.

KIR2DL2 KIR2DL3

7.07e-06293215248031
Pubmed

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

KIR2DL2 KIR2DL3

7.07e-06293223686481
Pubmed

Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells.

IL12B NFKB1

7.07e-06293214679201
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

7.07e-06293214550562
Pubmed

KIAA1199 interacts with glycogen phosphorylase kinase β-subunit (PHKB) to promote glycogen breakdown and cancer cell survival.

PHKB CEMIP

7.07e-06293225051373
Pubmed

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.

RYR1 RYR3

7.07e-0629329799464
Pubmed

Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency.

SPTB SLC4A1

7.07e-06293215070709
Pubmed

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.

KIR2DL2 KIR2DL3

7.07e-06293227030405
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

7.07e-06293215033925
Pubmed

Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.

RYR1 RYR3

7.07e-06293217118445
Pubmed

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

RYR1 RYR3

7.07e-06293211500519
Pubmed

Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.

ARF1 ARF3

7.07e-0629321577740
Pubmed

Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.

ARF1 ARF3

7.07e-0629328661066
Pubmed

Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.

IL12B NFKB1

7.07e-06293215004172
Pubmed

Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry.

STIM1 ITPR1

7.07e-06293230185837
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

7.07e-06293221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

7.07e-06293216678258
Pubmed

Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.

RYR1 RYR3

7.07e-06293212565913
Pubmed

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

RYR1 RYR3

7.07e-0629329192302
Pubmed

Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

RYR1 RYR3

7.07e-0629327556644
Pubmed

Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.

RYR1 RYR3

7.07e-06293215894801
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

7.07e-06293230542613
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

7.07e-06293215280431
InteractionPPFIA2 interactions

LIN7C PPFIA2 PPFIA1 ITSN1 TSC1 LIN7A

1.49e-0837916int:PPFIA2
InteractionANKRD20A4P interactions

ANKRD20A4P ANKRD20A2P ANKRD20A1

1.76e-066913int:ANKRD20A4P
InteractionANKRD20A2P interactions

ANKRD20A4P ANKRD20A2P ANKRD20A1

3.08e-067913int:ANKRD20A2P
InteractionANK1 interactions

SPTAN1 SPTB SLC4A3 RYR1 SLC4A1

5.35e-0656915int:ANK1
InteractionRYR2 interactions

AKAP6 RYR1 RYR2 RYR3 ITPR1

6.37e-0658915int:RYR2
InteractionANKRD20A1 interactions

ANKRD20A4P ANKRD20A2P ANKRD20A1

1.43e-0511913int:ANKRD20A1
InteractionAKAP6 interactions

AKAP6 RYR1 RYR2

5.79e-0517913int:AKAP6
InteractionPTPRS interactions

PPFIA2 PPFIA1 LRRTM4 PSMD1 TSC1 PCDH12

6.80e-05153916int:PTPRS
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2 RYR3

4.23e-083643287
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTAN1 SPTB

1.47e-0676431113
GeneFamilySterile alpha motif domain containing

STIM1 PPFIA4 PPFIA2 PPFIA1 TNKS2

1.48e-0588645760
GeneFamilyAnkyrin repeat domain containing

ANKRD20A4P ASB6 NFKB1 ANKRD20A2P ANKRD20A3P TNKS2 ANKRD20A1

2.29e-05242647403
GeneFamilyPDZ domain containing|Crumbs complex

LIN7C LIN7A

4.37e-0496421223
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ROCK2 SPTBN4 ITSN1 SPTB SOS1

8.08e-04206645682
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DL2 KIR2DL3

1.82e-0318642620
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

ARF1 ARF3

5.37e-0331642357
GeneFamilyEF-hand domain containing

SPTAN1 ITSN1 RYR2 RYR3

7.55e-03219644863
CoexpressionHOOI_ST7_TARGETS_DN

NAA25 PPFIA4 ANGPTL4 ARF3 ITPR1 CEMIP

3.49e-06115936M14801
CoexpressionHO_LIVER_CANCER_VASCULAR_INVASION

UBE3C RYR1 ZNF687

1.21e-0513933M8773
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

DOCK5 CCDC88C PAG1 LIN7C ANKRD20A4P PLCL2 PIP5K1B SLC39A4 ANKRD20A3P ANKRD20A8P ANKRD20A1 RYR1 CEMIP

2.44e-059309313MM893
CoexpressionFAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON

SPTBN4 PPFIA4 SYNE1 RYR2 RYR3 ITPR1

2.85e-05166936M39026
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma-erythroid_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ANKRD20A4P RIMKLA SPTB ANGPTL4 IFIT2 SLC4A1

1.95e-06177936b647667da62a91dbe3890820142626e26aa779d2
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PAG1 SPTB LRRTM4 EPB41L2 RYR2 LIN7A

2.02e-06178936185b44700f06ec58b3c09c80520502166c965fd6
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ROCK2 PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

2.60e-06186936888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

AKAP6 PAG1 PPFIA2 LRRTM4 RYR2 LIN7A

3.32e-061949365e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROCK2 SPTBN4 SYNE1 SPTAN1 RYR2 ITPR1

3.73e-061989368ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 ITSN1 NFKB1 RDH10 TDO2 RYR2

3.84e-061999368b86c69aaf60feff53aa782559cfece7342a23de
ToppCellBronchial-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAG1 SPTB LRRTM4 EPB41L2 RYR2 LIN7A

3.84e-06199936854628ce91068093c14bd4d45ba38c41469f3549
ToppCellAT2_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

ANKRD20A4P ANKRD20A2P ANKRD20A3P SLC4A3 RYR3

8.20e-06131935ff4e618bd944f852bbd34438f740187aca82460f
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA2 LRRTM4 RYR2 RYR3 LIN7A

2.16e-05160935c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA2 LRRTM4 RYR2 RYR3 LIN7A

2.16e-0516093525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12B PPFIA4 NFKB1 QPCT RYR1

2.73e-0516893599148986aa5628f67d85258c171b254be77a071c
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

2.97e-05171935080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

AKAP6 PPFIA2 THSD7B RYR2 RYR3

3.14e-05173935a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCelldroplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B PPFIA4 QPCT SYCE1 RYR1

3.22e-051749352afa5eea54b67c549c5058ece98296eee3829c11
ToppCell18-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

TICRR LIN7C PIP5K1B RYR3 SLC4A1

3.31e-051759357130b816e0c02309c161d8e9ad7cb4bc2469e251
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12B PPFIA4 QPCT SYCE1 RYR1

3.31e-051759354655d3daa95e8ffa7d5ee4180de06b2fec361bfb
ToppCell18-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

TICRR LIN7C PIP5K1B RYR3 SLC4A1

3.31e-05175935cc476b4244442418b8f21721a82a36209b556b36
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 SLC4A3 RYR1 ARF3 ITPR1

3.59e-05178935a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 SLC4A3 RYR1 ARF3 ITPR1

3.59e-051789351bddbc083c36657bd6910f7466126ab325e88176
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

PPFIA2 ANGPTL4 C1orf167 THSD7B RYR3

3.99e-05182935ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.21e-05184935c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.21e-0518493542d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCellControl-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

SYNE1 ANKRD20A2P ANKRD20A3P PCDH12 EPB41L2

4.32e-05185935a28187c2fd23564314b35759479ff2ca21f61485
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.43e-05186935962c2dada19185628ead77c32fcb07fa95114247
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.43e-05186935b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell390C-Lymphocytic-NK_cells-NK_cell_C|390C / Donor, Lineage, Cell class and subclass (all cells)

ANKRD20A4P PRKCH ANKRD20A2P KIR2DL3 ANKRD20A1

4.54e-051879351e8651e6c547384ace5a66b96c6b24a7f390a7ee
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

SYNE1 ANKRD20A2P ANKRD20A3P PCDH12 EPB41L2

4.54e-0518793554d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

AKAP6 PPFIA2 RYR2 RYR3 ITPR1

4.66e-0518893534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.66e-0518893547bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRTM4 EPB41L2 RYR2 LIN7A ITPR1

4.66e-0518893550c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

4.66e-051889352331a2bae1383820d598e93aa86c75b101069bac
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

AKAP6 ROCK2 PPFIA2 RYR3 ITPR1

4.78e-051899356b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 PPFIA4 SPTB LIN7A ITPR1

4.78e-05189935f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

CCDC88C SYNE1 PLCL2 PRKCH KIR2DL3

4.78e-05189935b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

AKAP6 PLCL2 PIP5K1B SLC4A3 RYR2

4.90e-05190935fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

5.02e-051919351626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

5.02e-05191935716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCellCOPD-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

5.02e-051919353480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCellCOPD-Myeloid-cDC1|COPD / Disease state, Lineage and Cell class

ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A1

5.15e-05192935bd3d00b094d92463b06023361a71240851a542b8
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

APOL3 PIP5K1B PRKCH THSD7B PCDH12

5.28e-05193935d338a7c0585b69947c37f44aa0381619493e31ea
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

SYNE1 PLCL2 PIP5K1B PCDH12 EPB41L2

5.41e-05194935777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

APOL3 PIP5K1B PRKCH THSD7B PCDH12

5.41e-0519493532ba2cf9b8726bc3c6e9dc24b54d22ff188bb12b
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

APOL3 PIP5K1B PRKCH THSD7B PCDH12

5.41e-0519493553a5e8863d79a052dff0758f389be5ac3883c721
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

APOL3 PIP5K1B PRKCH THSD7B PCDH12

5.54e-051959353826bfafe85f8aa9a508202ceb2b02e81b090498
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC88C APOL3 PRKCH THSD7B PCDH12

5.68e-051969352a2a93b89dcb98043cb1f8b422ac8c55e2edc37b
ToppCellPCW_10-12-Endothelial-Endothelial_mature|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC88C APOL3 PRKCH THSD7B PCDH12

5.68e-05196935481d79bdaec069ad2746a28d39eeee8d3edf7305
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

APOL3 PIP5K1B PRKCH THSD7B PCDH12

5.68e-051969350e8d649b50be2d707510b897bb97767b5847dff9
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|COVID-19 / Disease (COVID-19 only), tissue and cell type

ROCK2 PAG1 PPFIA2 RYR2 LIN7A

5.68e-05196935754a3613340932563cd8424d775e18b93c3a1aaa
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

5.82e-05197935f66945f9007d59d4208849c7fd727f8519713fbc
ToppCellParenchymal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

5.82e-0519793541dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SPTBN4 SYNE1 PPFIA2 RYR2 ITPR1

5.96e-05198935c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellmLN-(5)_Dendritic_cell-(53)_Lymphoid_DC|mLN / shred on region, Cell_type, and subtype

ANKRD20A4P ANKRD20A2P ANKRD20A3P PRAME ANKRD20A1

5.96e-05198935da84c76afe835aeee39da04b63c03549218b5d91
ToppCellmLN-Dendritic_cell-Lymphoid_DC|mLN / Region, Cell class and subclass

ANKRD20A4P ANKRD20A2P ANKRD20A3P PRAME ANKRD20A1

5.96e-051989353965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCelltumor_Lung-Endothelial_cells-Tip-like_ECs|Endothelial_cells / Location, Cell class and cell subclass

APOL3 PIP5K1B PCDH12 IFIT2 EPB41L2

6.10e-0519993580c8641cfd84436eadf2234f1313749e2f73331f
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PAG1 LRRTM4 EPB41L2 RYR2 LIN7A

6.10e-05199935929f809579368201331d9099d8904b6e3c41797b
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PAG1 SYNE1 QPCT ORAI2 LIN7A

6.25e-05200935808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

PAG1 PPFIA2 EPB41L2 RYR2 ARF3

6.25e-05200935bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell(53)_Lymphoid_DC|World / shred on Cell_type and subtype

ITSN1 ANKRD20A2P ANKRD20A3P PRAME ANKRD20A1

7.52e-0520893530212cfacad94a7cc562a69efa73a31259851515
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CCDC88C TDO2 RYR1 RYR3

1.41e-041269349b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 SYNE1 PIP5K1B EPB41L2

2.75e-041509348645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

AKAP6 RYR2 RYR3 ITPR1

2.97e-04153934ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

TRPM6 CCDC88C QPCT PIP5K1B

3.12e-041559349cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCellsevere_COVID-19-cDC|World / disease group, cell group and cell class (v2)

RIMKLA SLC4A3 ANKRD20A1 RYR1

3.19e-041569340a7e18ed8e13261c405eb6b9a183e99d8e1aac37
ToppCellsevere_COVID-19-cDC|severe_COVID-19 / disease group, cell group and cell class (v2)

RIMKLA SLC4A3 ANKRD20A1 RYR1

3.27e-04157934ec1978e07e2214048d015d8bb793c1d9991f6e37
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC88C PLCL2 SLC4A1 LIN7A

3.35e-04158934debebc8534a80e5500051f6fd352dc201585968d
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKB PPFIA2 RYR3 CEMIP

3.43e-041599344000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

LRRTM4 THSD7B RYR1 RYR2

3.43e-041599345335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROCK2 SYNE1 PIP5K1B EPB41L2

3.43e-041599345ca96db4281abb5f646150ccf36adc66ab201c78
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKB PPFIA2 RYR3 CEMIP

3.43e-041599347619d0d49738dd08daf01b42664691a5323aa793
ToppCelldroplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR SPTB PIP5K1B SLC4A1

3.52e-041609349f24ee4fe1ba4590dce5dd4d43707fb007dca82f
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

AKAP6 PPFIA2 SPTB RYR2

3.52e-04160934fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 THSD7B SLC4A1 LIN7A

3.52e-04160934174a4ab27114efcc63be36929b80680be3c35c9b
ToppCelldroplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR SPTB PIP5K1B SLC4A1

3.52e-041609343b3b99305558f5b49d050fb9b249007630ea9085
ToppCelldroplet-Heart-nan-24m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B PPFIA4 RYR1 SLC4A1

3.60e-041619347e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

LRRTM4 THSD7B RYR1 RYR2

3.77e-0416393419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88C PLCL2 MAST1 RYR1

3.95e-041659341b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88C PLCL2 MAST1 RYR1

3.95e-04165934b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RDH11 PPFIA4 NFKB1 ITPR1

3.95e-04165934479962ce1c3d6636ae62b6709635299748653801
ToppCellfacs-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 ITSN1 SPTB SLC4A1

4.04e-041669348d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCellnormal_Lymph_Node-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

AKAP6 ANKRD20A4P APOL3 LRRCC1

4.04e-041669346210a136efb99d70c2026b6454363f1bd2723558
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PHKB PPFIA2 RYR3 CEMIP

4.04e-04166934bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD141+_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

IL12B APOL3 QPCT RYR2

4.04e-041669349f14e3ef19d5903278c040be1c477501237173fa
ToppCelldroplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 NFKB1 QPCT RYR1

4.04e-04166934c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD20A4P SYNE1 LRRCC1 KIR2DL3

4.04e-04166934217e0549f88819d02156ea64e8547b658b1c7aef
ToppCellfacs-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 ITSN1 SPTB SLC4A1

4.04e-04166934f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PHKB PPFIA2 RYR3 CEMIP

4.04e-041669345e3b998d740b24f790fad37350d704ca0ea10b77
ToppCellfacs-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 ITSN1 SPTB SLC4A1

4.04e-04166934a5074c96c6561273029aceb93402a7e038140f50
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHD1L EPB41L2 RYR1 CEMIP

4.32e-04169934a0681317867e31319210a23e56660a53f4529efe
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN4 TICRR PAG1 SYNE1

4.32e-04169934b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STIM1 THSD7B SLC4A1 LIN7A

4.32e-041699342a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 PPFIA4 QPCT RYR1

4.32e-0416993446f0f0de9a0894c454f93032e7a7a800f47c8276
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 NFKB1 QPCT RYR1

4.32e-04169934735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTBN4 TICRR PAG1 SYNE1

4.32e-0416993483d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITSN1 SPTB PIP5K1B SLC4A1

4.42e-04170934b180ec9a1b79025a180c8559c27c31272410dea8
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITSN1 SPTB PIP5K1B SLC4A1

4.42e-0417093437c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 SYNE1 PIP5K1B EPB41L2

4.42e-04170934876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 SYNE1 PIP5K1B EPB41L2

4.42e-041709341f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SYNE1 PRKCH KIR2DL2 KIR2DL3

4.52e-04171934adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-lymphocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B PPFIA4 QPCT RYR1

4.52e-041719340385d5834ae16bbb0c6a68893fec60e4dd1e478d
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B PPFIA4 QPCT RYR1

4.52e-04171934a3e3fe0cbab21abb178c482f5951e576529f7e30
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2 RYR3 ITPR1

9.04e-097934CID009547999
DrugBr2BAPTA

RYR1 RYR2 RYR3 ITPR1

9.04e-097934CID003081001
DrugPCB 95

RYR1 RYR2 RYR3 ITPR1

5.38e-0810934CID000038012
Drugcis-diammineplatinum(II

RYR1 RYR2 RYR3

6.60e-083933CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2 RYR3

6.60e-083933CID002750949
Drug8N3-cADPR

RYR1 RYR2 RYR3

6.60e-083933CID000127713
Drugaminodantrolene

RYR1 RYR2 RYR3

6.60e-083933CID009570289
Drug2-hydroxycarbazole

RYR1 RYR2 RYR3

6.60e-083933CID000093551
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2 RYR3

6.60e-083933CID005748312
DrugR 478

RYR1 RYR2 RYR3 ITPR1

8.42e-0811934CID000084223
Drug8-amino-cADPR

RYR1 RYR2 RYR3 ITPR1

8.42e-0811934CID003081323
DrugPCB74

RYR1 RYR2 RYR3

2.63e-074933CID000036218
Drug148504-47-6

RYR1 RYR2 RYR3

2.63e-074933CID006444275
DrugSC 38249

RYR1 RYR2 RYR3

2.63e-074933CID000134834
DrugAC1L1U7A

RYR1 RYR2 RYR3

2.63e-074933CID000035682
DrugGvapspat amide

RYR1 RYR2 RYR3 ITPR1

3.44e-0715934CID000125015
Drugmag-fura-2

TRPM6 RYR1 RYR2 RYR3 ITPR1

4.01e-0737935CID000123839
Drug4-chloro-m-cresol

AKAP6 RYR1 RYR2 RYR3 ITPR1

4.01e-0737935CID000001732
DrugFura-2AM

ROCK2 PRKCH RYR1 RYR2 RYR3 ITPR1

8.63e-0779936CID000105091
DrugNSC759576

IL12B NFKB1 RYR1 RYR2 RYR3 SLC4A1 ITPR1 SOS1

1.17e-06191938CID000003075
Drugchloro-m-cresol

RYR1 RYR2 RYR3

1.31e-066933CID000012008
DrugMBED

RYR1 RYR2 RYR3

1.31e-066933CID000129958
DrugAC1O528X

RYR1 RYR2 RYR3

1.31e-066933CID006475857
DrugNSC114784

RYR1 RYR2 RYR3

1.31e-066933CID000419425
DrugAC1OAGFB

ROCK2 SPTBN4 SPTAN1 SPTB NFKB1 PIP5K1B PRKCH EPB41L2 ARF1 ARF3 ITPR1 SOS1

2.00e-065399312CID006857345
DrugAzumoleno

RYR1 RYR2 RYR3

2.28e-067933CID000056259
Drugborate

TRPM6 STIM1 RYR1 RYR2 RYR3 ITPR1

3.07e-0698936CID000007628
DrugT0702

RYR1 RYR2 RYR3 ITPR1

3.09e-0625934CID000005908
Drugaescine

ROCK2 PRKCH RYR1 ARF1 RYR3

4.67e-0660935CID004555259
Drugfura 2

PRKCH RYR1 RYR2 RYR3 ITPR1

6.94e-0665935CID000057054
DrugCaffeine

STIM1 IL12B NFKB1 ANGPTL4 TDO2 TNKS2 RYR1 RYR2 ARF1 RYR3 ITPR1

8.16e-065159311ctd:D002110
Drugstrontium

PRKCH RYR1 RYR2 RYR3 ITPR1

8.68e-0668935CID000104798
DrugAC1L2AC7

NFKB1 RYR1 RYR2 RYR3 ITPR1

9.33e-0669935CID000068733
DrugCNS 1145

RYR1 RYR2 RYR3 ITPR1

9.75e-0633934CID000190902
DrugIHC-64

RYR1 RYR2 RYR3 ITPR1

9.75e-0633934CID000162753
DrugPCB 66

RYR1 RYR2 RYR3

1.06e-0511933CID000036185
DrugCAS 298-57-7

RYR1 RYR2 RYR3 SLC4A1 ITPR1

1.23e-0573935CID000002761
Drug2-aminoethyl diphenylborinate

TRPM6 STIM1 ROCK2 PRKCH RYR1 RYR3

1.37e-05127936CID000001598
DrugRyanodine

RYR1 RYR2 RYR3

1.41e-0512933ctd:D012433
DrugBenfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

MTHFR SPTAN1 EIF4G2 TNKS2 ORAI2 IFIT2 ITPR1

1.49e-051949372621_UP
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; HL60; HG-U133A

ROCK2 CCDC88C SPTAN1 ZBTB40 IFIT2 LIN7A ITPR1

1.60e-051969372044_DN
DrugMefenamic acid [61-68-7]; Up 200; 16.6uM; PC3; HT_HG-U133A

ROCK2 CCDC88C PPFIA1 ANGPTL4 CHD1L ORAI2 SLC4A3

1.60e-051969371821_UP
Drugmaleimide

SPTBN4 SPTAN1 SPTB APOL3 PRKCH SLC4A1

1.64e-05131936CID000010935
DrugBenzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

AKAP6 STIM1 SPTB QPCT ORAI2 RYR2 ITPR1

1.65e-051979373635_DN
Drugthiophenone

SYNE1 TDO2

1.65e-052932CID009548690
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

1.65e-052932ctd:C005147
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; HL60; HG-U133A

LIN7C PPFIA1 SPTAN1 SPTB ZBTB40 ORAI2 ARF3

1.70e-051989371376_UP
DrugAC1L98DX

RYR1 RYR2 RYR3 ITPR1

1.73e-0538934CID000439957
DrugADPribulose

SPTBN4 SPTAN1 SPTB

1.83e-0513933CID000197570
DrugNSC299933

STIM1 RYR1 RYR3

1.83e-0513933CID000431902
DrugNAADP

RYR1 RYR2 RYR3 ITPR1

1.92e-0539934CID000123952
DrugD-myo-inositol-1,4,5-triphosphate

STIM1 SPTB PLCL2 EIF4G2 APOL3 PRKCH RYR1 RYR2 RYR3 ITPR1 SOS1

2.03e-055689311CID000000806
Drugdipyrone

RYR1 RYR2 RYR3 SLC4A1

2.13e-0540934CID000003110
Drugphenylhydrazine

SPTBN4 SPTAN1 SPTB TDO2 SLC4A1

2.17e-0582935CID000007516
DrugFPL 64176

RYR1 RYR2 RYR3

2.90e-0515933CID000003423
Drugescina

RYR1 RYR2 RYR3 ITPR1

3.12e-0544934CID006433489
Druglindane

NFKB1 TDO2 RYR1 RYR2 RYR3 ITPR1

4.08e-05154936CID000000727
Drugkazinol B

RYR1 RYR2 RYR3

4.30e-0517933CID000480869
Drugts M

RYR1 RYR2 RYR3 ITPR1

4.42e-0548934CID000428025
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

4.94e-053932CID000080262
Drugflubendiamide

RYR1 RYR3

4.94e-053932CID011193251
Druglysosphingomyelin

ROCK2 PRKCH RYR1 RYR2 RYR3 ITPR1

5.05e-05160936CID000005263
Drugmethylcoumarin

RYR1 RYR2 RYR3

5.15e-0518933CID000007092
Drugindo-1

PRKCH RYR1 RYR2 RYR3 ITPR1

5.39e-0599935CID000105060
DrugAC1MW7VF

RYR1 RYR2 RYR3

6.10e-0519933CID000414699
DrugAC1L380G

RYR1 RYR2 RYR3

6.10e-0519933CID000084698
Drugloperamide

PRKCH RYR1 RYR2 RYR3 ITPR1

7.14e-05105935CID000003954
Drugphosphine oxide

AKAP6 PRKCH RYR1 RYR2 RYR3

7.81e-05107935CID000166931
DrugNSC226080

ROCK2 DOCK5 IL12B NFKB1 EIF4G2 PSMD1 PRKCH TSC1 RYR1 RYR2 RYR3 ITPR1

8.06e-057829312CID000005040
DrugCinildipine

RYR1 RYR2 RYR3 ITPR1

8.14e-0556934CID000002752
Drugindo-1/AM

RYR1 RYR2 RYR3

8.32e-0521933CID000123918
DrugAC1L1CR9

RYR1 RYR3 ITPR1

8.32e-0521933CID000002023
DrugA-30

RYR1 RYR3

9.85e-054932CID003028528
DrugBastadin 10

RYR1 RYR3

9.85e-054932CID009589366
Drugnilvadipine

RYR1 RYR2 RYR3 ITPR1

1.07e-0460934CID000004494
DrugIAA-94

RYR1 RYR2 RYR3 ITPR1

1.14e-0461934CID000003667
Drugapocynin

ROCK2 NFKB1 PRKCH RYR1 RYR2 RYR3

1.16e-04186936CID000002214
DrugAC1NBU2S

NFKB1 RYR1 RYR2 RYR3 ITPR1

1.19e-04117935CID004473765
Druglercanidipine

RYR1 RYR2 RYR3 ITPR1

1.29e-0463934CID000065866
DrugAC1L96VB

SPTAN1 NFKB1 TNKS2 RYR1 RYR2 RYR3

1.34e-04191936CID000439200
Drugdimyristoylphosphatidylcholine

SPTBN4 SPTAN1 SPTB SLC4A1

1.37e-0464934CID000026197
Drugfluo-3

PRKCH RYR1 RYR2 RYR3 ITPR1

1.45e-04122935CID000104978
DrugClorocruoro Hem

ROCK2 RYR1 RYR2 RYR3 ITPR1

1.51e-04123935CID003518809
Drug2-propylpentanoic acid; Up 200; 500uM; HL60; HT_HG-U133A

RDH11 MTHFR ITSN1 QPCT PCDH12 ORAI2

1.54e-041969361181_UP
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; HL60; HG-U133A

STIM1 NRBP1 PANK3 SPTAN1 ZBTB40 EPB41L2

1.54e-041969362005_DN
DrugHydroflumethiazide [135-09-1]; Down 200; 12uM; HL60; HT_HG-U133A

ROCK2 TULP4 ASB6 PPFIA1 ITSN1 SOS1

1.54e-041969361851_DN
DrugBetaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; PC3; HT_HG-U133A

ROCK2 SYNE1 PRKCH ORAI2 IFIT2 ITPR1

1.59e-041979364608_DN
DrugMimosine [500-44-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A

DOCK5 CCDC88C SPTAN1 ITSN1 QPCT ITPR1

1.59e-041979365302_UP
DrugQuipazine dimaleate salt [4774-24-7]; Down 200; 9uM; HL60; HG-U133A

SPTAN1 ARMH3 IFIT2 ARF3 ITPR1 SOS1

1.59e-041979361789_DN
Drug4-ethylguaiacol

QPCT RYR1

1.64e-045932CID000062465
DrugA 68930

RYR1 RYR2

1.64e-045932ctd:C065380
Druggallopamil

RYR1 RYR2 RYR3 ITPR1

1.64e-0467934CID000001234
DrugNSC-695672

SYNE1 NFKB1 RYR1 RYR3

1.64e-0467934CID000393593
DrugRanitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A

TULP4 PPFIA1 CHD1L TNKS2 ARMH3 PRAME

1.68e-041999366324_DN
DrugtBuBHQ

STIM1 RYR1 RYR2 RYR3

1.84e-0469934CID000002374
DrugAC1L1JVU

ROCK2 PRKCH RYR1 RYR3

2.17e-0472934CID000005229
Drugcaged InsP3

RYR1 RYR3 ITPR1

2.23e-0429933CID000122248
Druglanthanum

STIM1 RYR1 RYR2 RYR3 ITPR1

2.41e-04136935CID000023926
Drugethosuximide

RYR1 RYR2 RYR3 ITPR1

2.41e-0474934CID000003291
Drug2,4,6-trichloroanisole

QPCT RYR1

2.45e-046932CID000006884
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2 RYR3

2.31e-083853DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2 RYR3

2.31e-083853DOID:8545 (implicated_via_orthology)
Diseasemidregional pro atrial natriuretic peptide measurement

MTHFR C1orf167

8.20e-062852EFO_0008468
Diseasemean reticulocyte volume

STIM1 MTHFR ITSN1 SPTB NFKB1 PLCL2 ZBTB40 MAST1 REXO1 EPB41L2 SLC4A1

1.85e-057998511EFO_0010701
DiseaseElliptocytosis found

SPTB SLC4A1

4.90e-054852C0427480
DiseaseHereditary elliptocytosis

SPTB SLC4A1

4.90e-054852cv:C0013902
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN4 SPTB

4.90e-054852DOID:0050882 (implicated_via_orthology)
Diseasehereditary spherocytosis (is_implicated_in)

SPTB SLC4A1

8.15e-055852DOID:12971 (is_implicated_in)
DiseaseHereditary spherocytosis

SPTB SLC4A1

8.15e-055852cv:C0037889
DiseaseAnemia, hereditary spherocytic hemolytic

SPTB SLC4A1

8.15e-055852C0221409
DiseaseElliptocytosis, Hereditary

SPTB SLC4A1

1.22e-046852C0013902
Diseasefasting blood glucose measurement

THOC7 LRRTM4 QPCT PIP5K1B NDUFAF6 TDO2

1.85e-04287856EFO_0004465
DiseaseHereditary spherocytosis

SPTB SLC4A1

2.27e-048852C0037889
DiseaseHematological Disease

MTHFR SLC4A1

2.27e-048852C0018939
Diseasealcohol use disorder (implicated_via_orthology)

ANGPTL4 PRKCH RYR1 RYR2 RYR3

2.56e-04195855DOID:1574 (implicated_via_orthology)
Diseasemean corpuscular hemoglobin concentration

CUL1 TICRR MTHFR ITSN1 SPTB NFKB1 PLCL2 MAST1 UBE3C EPB41L2 SLC4A1

3.27e-0411058511EFO_0004528
Diseaseurate measurement, bone density

AKAP6 TRPM6 DOCK5 SYNE1 PPFIA2 EIF4G2 TDO2 ITPR1

4.18e-04619858EFO_0003923, EFO_0004531
DiseaseSarcomatoid Renal Cell Carcinoma

SPTBN4 TSC1 PRAME RYR1

5.21e-04128854C1266043
DiseaseChromophobe Renal Cell Carcinoma

SPTBN4 TSC1 PRAME RYR1

5.21e-04128854C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

SPTBN4 TSC1 PRAME RYR1

5.21e-04128854C1266044
DiseasePapillary Renal Cell Carcinoma

SPTBN4 TSC1 PRAME RYR1

5.21e-04128854C1306837
DiseaseRenal Cell Carcinoma

SPTBN4 TSC1 PRAME RYR1

5.21e-04128854C0007134
DiseaseAnemia, Hemolytic, Acquired

SPTB SLC4A1

6.27e-0413852C0002879
DiseaseAnemia, Hemolytic

SPTB SLC4A1

6.27e-0413852C0002878
DiseaseAnemia, Microangiopathic

SPTB SLC4A1

6.27e-0413852C0002889
DiseaseAutosomal Dominant Myotubular Myopathy

STIM1 RYR1

6.27e-0413852C3661489
DiseaseCentronuclear myopathy

STIM1 RYR1

6.27e-0413852C0175709
DiseaseX-linked centronuclear myopathy

STIM1 RYR1

6.27e-0413852C0410203
DiseaseMyopathy, Centronuclear, 1

STIM1 RYR1

6.27e-0413852C4551952
DiseaseMicroangiopathic hemolytic anemia

SPTB SLC4A1

6.27e-0413852C0221021
DiseaseCongenital Structural Myopathy

STIM1 RYR1

6.27e-0413852C0752282
DiseaseMyopathy, Centronuclear, Autosomal Dominant

STIM1 RYR1

7.30e-0414852C1834558
DiseaseTubular Aggregate Myopathy

STIM1 RYR1

7.30e-0414852C0410207
Diseasehemoglobin A1 measurement

NAA25 TULP4 ITSN1 SPTB APOL3 NDUFAF6 UBE3C

7.65e-04520857EFO_0007629
Diseaseglycerate measurement

THSD7B RYR3

8.40e-0415852EFO_0021029
DiseaseAutosomal Recessive Centronuclear Myopathy

STIM1 RYR1

8.40e-0415852C3645536
Diseaseanemia (implicated_via_orthology)

SLC4A3 SLC4A1

8.40e-0415852DOID:2355 (implicated_via_orthology)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

SPTBN4 TSC1 PRAME RYR1

8.98e-04148854C0279702
Diseasediacylglycerol 44:7 measurement

NRBP1 IFT172

9.59e-0416852EFO_0020069
DiseaseCongenital Fiber Type Disproportion

STIM1 RYR1

1.22e-0318852C0546264
Diseasesusceptibility to scarlet fever measurement

PPFIA2 NFKB1 SOS1

1.56e-0379853EFO_0008409
Diseasepulmonary hypertension (biomarker_via_orthology)

RYR1 RYR2 RYR3

1.62e-0380853DOID:6432 (biomarker_via_orthology)
Diseaseobsolete_red blood cell distribution width

DOCK5 MTHFR ITSN1 SPTB ANGPTL4 PLCL2 APOL3 ZBTB40 MAST1 REXO1 SLC4A1

1.66e-0313478511EFO_0005192
Diseaseuric acid measurement

NAA25 VPS45 NFKB1 PIP5K1B NDUFAF6 EPB41L2 CEMIP

1.91e-03610857EFO_0004761
DiseaseWest Syndrome

SPTAN1 TSC1

2.17e-0324852C0037769
Diseasecalcium measurement

TRPM6 STIM1 QPCT PIP5K1B SLC4A1 ITPR1 SOS1

2.25e-03628857EFO_0004838
Diseasecreatinine measurement

NRBP1 PPFIA2 NFKB1 CYP26C1 APOL3 PSMD1 PIP5K1B RYR1 CEMIP

2.26e-03995859EFO_0004518
Diseasecognitive function measurement

AKAP6 TULP4 PPFIA2 PLCL2 CYP26C1 MAST1 THSD7B ARMH3 RYR3 SOS1 CEMIP

2.70e-0314348511EFO_0008354

Protein segments in the cluster

PeptideGeneStartEntry
KLLSHGAHIEALDKD

ANKRD20A1

151

Q5TYW2
LLLKHSHPNDDKDSG

SLC4A3

421

P48751
LLALKGHDALGHQEE

C1orf167

1321

Q5SNV9
LLDHKHLDHEVAKPA

ANGPTL4

146

Q9BY76
KLLSHGAHIEALDKD

ANKRD20A8P

151

Q5CZ79
ALLLKHSHAGELEAL

SLC4A1

156

P02730
KLLSHGAHIEALDKD

ANKRD20A4P

151

Q4UJ75
AAEITDKLGLHSLRH

ARF3

136

P61204
DTKDEHRLHSGKLCL

ARMH3

381

Q5T2E6
AADKHGKTALLHALA

ASB6

166

Q9NWX5
HISEGGKLVIKDHDE

CEMIP

76

Q8WUJ3
HELHELGLLKDHSLE

QPCT

276

Q16769
GKAVFLARDKHHLSD

RIMKLA

161

Q8IXN7
SLHLITIKAHDADLG

PCDH12

476

Q9NPG4
ELHKLKVQLDGHERS

ORAI2

236

Q96SN7
KLLSHGAHIEALDKD

ANKRD20A2P

151

Q5SQ80
RHKKLHLGLDVEASE

C8orf48

146

Q96LL4
HPEAGSFEADLKHLK

MTHFR

201

P42898
HREGKFKDTLHLIGE

KIR2DL2

61

P43627
EHHEKAVELLKAAKD

LIN7A

166

O14910
EHHEKAVELLKAAQG

LIN7C

151

Q9NUP9
FAGLLKLKELHLEHN

LRRTM4

201

Q86VH4
KSDLLHTKSLRGHKD

EURL

46

Q9NYK6
AVLLNKLHHAADLEK

ITPR1

86

Q14643
HREGKFKDTLHLIGE

KIR2DL3

61

P43628
LKALKSLFEHHKALD

PPFIA4

151

O75335
KTLHRNLELEHKELG

CCDC88C

1196

Q9P219
LEEKVAELHKTHRGL

EPB41L2

371

O43491
VDLHHAKDSEGVDIK

EPB41L2

406

O43491
LGIHFLDHSLKEKEE

PIP5K1B

271

O14986
EILGIKDLHADHAAS

NDUFAF6

191

Q330K2
GALKELHEVGLHDNL

LRRC18

141

Q8N456
LKALKSLFEHHKALD

PPFIA1

161

Q13136
VLSHSLLLLHKKEDG

IL12B

96

P29460
ELGKLDLIHESILHK

EIF4G2

216

P78344
AEGHAKEGHLVKTDI

MAST1

306

Q9Y2H9
DLLSDTHLHLGKELE

IFT172

1026

Q9UG01
EGVKHHLTLLLKLED

NRBP1

456

Q9UHY1
LHLHKLDELDCLVKG

PANK3

131

Q9H999
KLLSHGAHIEALDKD

ANKRD20A3P

151

Q5VUR7
SVHDEEGKLLEKAIH

DOCK5

471

Q9H7D0
DGLGELKKLLETHIH

CUL1

331

Q13616
PDHSHLKHALEKAEE

ITSN1

1401

Q15811
HLTEASGKLHLLDKL

CHD1L

341

Q86WJ1
KHLHEGAKSASAEEL

APOL3

361

O95236
AAEITDKLGLHSLRH

ARF1

136

P84077
HLEGAISEKLHEDKA

CYP26C1

246

Q6V0L0
IGHAVAHLKKADEAN

IFIT2

316

P09913
ISLLDKHGRNHKVLD

RYR1

586

P21817
EGHIKSIISLLDKHG

RYR2

591

Q92736
DDKGRTHELEHSAIK

PHKB

106

Q93100
ALKSLFEHHKALDEK

PPFIA2

176

O75334
LHETGIFKKHLLLDA

NXPE1

376

Q8N323
IHKLHKFLGSDEEDK

NUP88

421

Q99567
NEFGHHKIDVLKADL

METTL24

256

Q5JXM2
GHSLESDLLALKVIH

REXO1

1141

Q8N1G1
AKGFLAEEKHLHVLI

RDH11

111

Q8TC12
HLHLETFKAVLDGLD

PRAME

91

P78395
HEAEEKLSEHKALVS

SYNE1

5136

Q8NF91
HNENLLLEGKAHTKD

SYNE1

6146

Q8NF91
SLFDEKRHEHLLSKG

TDO2

266

P48775
HEHLHSIGTKEGLKE

PLCL2

1036

Q9UPR0
SHADHLLALLESPKA

SLC39A4

121

Q6P5W5
ASLGVIHKGHEKEAL

PSMD1

406

Q99460
LKHKLDHVIGELEDT

THAP6

151

Q8TBB0
DIHELSVKLLGHIED

SOS1

251

Q07889
KALLALNHGLDKAHS

STIM1

581

Q13586
EIKEVAAAAHLEKGH

PAG1

186

Q9NWQ8
HESLSHELKAAEKDG

RDH10

221

Q8IZV5
EEGHQLLELIASHKA

AKAP6

841

Q13023
GDRDHEHLQKSAKAL

TULP4

791

Q9NRJ4
ELESHLAKKDHLLLE

TSC1

911

Q92574
LLSEAEHHGIGDLKS

TICRR

1466

Q7Z2Z1
LESEGKDHGLELSIH

TICRR

1716

Q7Z2Z1
SILKDILHLAEHDGT

ZNF749

91

O43361
KHEPIAHLLDGQDKA

TRPM6

1406

Q9BX84
SLLDKHGRNHKVLDI

RYR3

586

Q15413
KELDSLHGEKVHLKE

SYCE1

86

Q8N0S2
LQKKHALLEADVAAH

SPTAN1

716

Q13813
LLDKHGHLKLADFGT

ROCK2

221

O75116
HLVEADDLLQKHGLL

SPTBN4

566

Q9H254
HETLDHLIKGRLKEN

VPS45

471

Q9NRW7
EIKAHLLSAEFGKHL

SPTB

546

P11277
FGKHLLEVEDLLQKH

SPTB

556

P11277
ALGKELEHLSHIKES

THOC7

141

Q6I9Y2
DVHAKDKGDLVPLHN

TNKS2

236

Q9H2K2
LHKETHLGKVSLEGE

ZNF550

146

Q7Z398
HDTFDLHGKILKSNL

ZNF613

126

Q6PF04
CSLLLHAREHKDKGL

ZNF687

576

Q8N1G0
LLLSHAAHLEGKKDN

THSD7B

26

Q9C0I4
SALNKHGEIHAREKL

ZSCAN29

831

Q8IWY8
SLLKDILHLAEHDGT

ZNF17

91

P17021
DSKKELDKHQLEAHG

ZBTB40

776

Q9NUA8
KLLGTSADVDIHHLA

UBE3C

846

Q15386
KLDNVLLDHEGHCKL

PRKCH

481

P24723
KHANEKEDIHSLALL

LRRCC1

456

Q9C099
DHIKGLETHLIALKL

NAA25

906

Q14CX7
NSVLHLAAKEGHDKV

NFKB1

616

P19838