Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionArp2/3 complex binding

WHAMM JMY WASF2

4.77e-0716203GO:0071933
GeneOntologyMolecularFunctionactin binding

FMNL2 WHAMM JMY WASL VASP WASF2

5.38e-06479206GO:0003779
GeneOntologyMolecularFunctionprofilin binding

VASP PCLO

7.39e-0513202GO:0005522
GeneOntologyMolecularFunctioncytoskeletal protein binding

FMNL2 WHAMM JMY WASL VASP WASF2

5.45e-041099206GO:0008092
GeneOntologyMolecularFunctionmicrotubule binding

WHAMM JMY WASL

3.41e-03308203GO:0008017
GeneOntologyMolecularFunctioncadherin binding

FMNL2 VASP WASF2

4.46e-03339203GO:0045296
GeneOntologyBiologicalProcessactin nucleation

WHAMM JMY WASL WASF2

3.36e-0765194GO:0045010
GeneOntologyBiologicalProcessactin cytoskeleton organization

FMNL2 WHAMM JMY WASL VASP WASF2 PCLO

4.41e-06803197GO:0030036
GeneOntologyBiologicalProcessactin filament-based process

FMNL2 WHAMM JMY WASL VASP WASF2 PCLO

1.02e-05912197GO:0030029
GeneOntologyBiologicalProcessArp2/3 complex-mediated actin nucleation

WHAMM JMY WASF2

1.05e-0547193GO:0034314
GeneOntologyBiologicalProcesspositive regulation of actin nucleation

WHAMM WASF2

7.27e-0514192GO:0051127
GeneOntologyBiologicalProcessactin filament organization

WHAMM JMY WASL VASP WASF2

7.83e-05509195GO:0007015
GeneOntologyBiologicalProcessregulation of plasma membrane organization

FASLG WASL

1.51e-0420192GO:1903729
GeneOntologyBiologicalProcessplasma membrane tubulation

WHAMM WASL

1.51e-0420192GO:0097320
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

WASL WASF2

3.68e-0431192GO:0098974
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

WASL WASF2

4.70e-0435192GO:0099188
GeneOntologyBiologicalProcessregulation of actin nucleation

WHAMM WASF2

6.45e-0441192GO:0051125
GeneOntologyBiologicalProcessplasma membrane organization

FASLG WHAMM WASL

6.48e-04188193GO:0007009
GeneOntologyBiologicalProcesspositive regulation of supramolecular fiber organization

WHAMM VASP WASF2

7.32e-04196193GO:1902905
GeneOntologyBiologicalProcesspositive regulation of cytoskeleton organization

WHAMM VASP WASF2

8.34e-04205193GO:0051495
GeneOntologyBiologicalProcesssupramolecular fiber organization

WHAMM JMY WASL VASP WASF2

1.44e-03957195GO:0097435
GeneOntologyCellularComponentlamellipodium

RAPH1 WASL VASP WASF2

6.02e-05230204GO:0030027
GeneOntologyCellularComponentcell leading edge

RAPH1 JMY WASL VASP WASF2

8.84e-05500205GO:0031252
DomainWH2_dom

WHAMM JMY WASL WASF2

4.53e-0921194IPR003124
DomainWH2

WHAMM JMY WASL WASF2

8.02e-0924194PS51082
DomainWH2

JMY WASL WASF2

3.23e-0714193SM00246
DomainJMY/WHAMM_N

WHAMM JMY

9.80e-072192IPR031808
DomainWHAMM-JMY_N

WHAMM JMY

9.80e-072192PF15920
DomainJMY/WHAMM

WHAMM JMY

9.80e-072192IPR031738
DomainJMY

WHAMM JMY

9.80e-072192PF15871
DomainWH1

WASL VASP

5.36e-0511192SM00461
DomainWH1

WASL VASP

5.36e-0511192PF00568
DomainWH1/EVH1_dom

WASL VASP

5.36e-0511192IPR000697
Domain-

ANTXRL WASL

6.43e-05121923.90.810.10
DomainWH1

WASL VASP

7.60e-0513192PS50229
DomainWH2

WASL WASF2

1.17e-0416192PF02205
DomainCRIB_dom

ANTXRL WASL

2.04e-0421192IPR000095
DomainZnF_U1

ZFHX4 ZNF318

3.92e-0429192SM00451
DomainZnf_U1

ZFHX4 ZNF318

3.92e-0429192IPR003604
Domain-

RAPH1 WASL VASP

6.88e-033911932.30.29.30
DomainPH_dom-like

RAPH1 WASL VASP

8.70e-03426193IPR011993
DomainHomeobox_CS

ZFHX4 HOXB4

1.51e-02186192IPR017970
DomainHomeobox

ZFHX4 HOXB4

2.32e-02234192PF00046
DomainHOMEOBOX_1

ZFHX4 HOXB4

2.36e-02236192PS00027
DomainHOX

ZFHX4 HOXB4

2.38e-02237192SM00389
DomainHomeobox_dom

ZFHX4 HOXB4

2.42e-02239192IPR001356
DomainHOMEOBOX_2

ZFHX4 HOXB4

2.42e-02239192PS50071
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2

4.10e-0510142MM1528
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2

6.01e-0512142M7825
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

WASL VASP WASF2

1.06e-0496143M16121
PathwaySIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES

WASL VASP

5.35e-0435142M16801
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

WASL WASF2

5.66e-0436142M27549
PathwayREACTOME_RHO_GTPASE_CYCLE

FMNL2 WHAMM WASL WASF2

7.95e-04450144M27078
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

FNBP4 RAPH1 ZC3H4 WASL VASP WASF2 ZNF318

8.71e-0950620730890647
Pubmed

Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.

RAPH1 WASL VASP

1.10e-071720314506234
Pubmed

Degradation of actin nucleators affects cortical polarity of aged mouse oocytes.

JMY WASF2

3.14e-07220222306711
Pubmed

N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor.

WASL WASF2

3.14e-07220215496413
Pubmed

Nucleation promoting factors regulate the expression and localization of Arp2/3 complex during meiosis of mouse oocytes.

JMY WASF2

3.14e-07220223272233
Pubmed

Role of nucleation-promoting factors in mouse early embryo development.

JMY WASF2

3.14e-07220223552571
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

FNBP4 FASLG WASL WASF2

4.58e-0711120422558309
Pubmed

The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse.

FASLG WASL

9.42e-07320216595635
Pubmed

Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.

RAPH1 VASP

9.42e-07320226295568
Pubmed

Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin.

WASL WASF2

9.42e-07320216483316
Pubmed

Cdc42 interacts with the exocyst complex to promote phagocytosis.

WASL WASF2

9.42e-07320223295348
Pubmed

WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments.

WASL WASF2

9.42e-07320221769917
Pubmed

A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex.

RAPH1 VASP

1.88e-06420222915108
Pubmed

Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.

WASL WASF2

1.88e-0642029950691
Pubmed

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.

RAPH1 VASP

1.88e-06420215469845
Pubmed

The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.

WHAMM JMY

1.88e-06420233872315
Pubmed

c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.

RAPH1 VASP

3.14e-06520220417104
Pubmed

FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.

WASL WASF2

3.14e-06520214697212
Pubmed

PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.

RAPH1 VASP

3.14e-06520215642358
Pubmed

Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.

RAPH1 VASP

4.71e-06620224076656
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WASL WASF2

8.78e-06820211146629
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WASL WASF2

8.78e-06820210381382
Pubmed

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

WASL WASF2

8.78e-06820211130076
Pubmed

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.

WASL VASP

1.13e-05920215148305
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

WASL WASF2

2.44e-051320216723544
Pubmed

Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.

ZIC5 VASP

7.21e-052220234184034
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

WASL VASP WASF2

9.18e-0515420316055720
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

RAPH1 FMNL2 VASP WASF2

2.72e-0456520425468996
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZFHX4 FMNL2 ZC3H4 ZNF318 ALG13

3.50e-04111620531753913
Pubmed

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.

RAPH1 R3HDM1

5.45e-046020219075228
InteractionPFN1 interactions

RAPH1 FMNL2 JMY WASL VASP WASF2 PCLO ALG13

9.28e-09509198int:PFN1
InteractionPRPF40A interactions

FNBP4 FASLG FMNL2 WASL VASP WASF2 ALG13

9.93e-08446197int:PRPF40A
InteractionARHGAP12 interactions

FNBP4 RAPH1 WASL WASF2

4.42e-0768194int:ARHGAP12
InteractionACTC1 interactions

FNBP4 RAPH1 ZC3H4 WASL VASP WASF2 ZNF318

1.96e-06694197int:ACTC1
InteractionNCK2 interactions

RAPH1 FASLG WASL VASP WASF2

3.58e-06262195int:NCK2
InteractionDNMBP interactions

RAPH1 FASLG WASL VASP

4.93e-06124194int:DNMBP
InteractionVASP interactions

RAPH1 JMY VASP WASF2 ALG13

6.28e-06294195int:VASP
InteractionSMG7 interactions

ZC3H4 VASP ZNF318 ALG13 R3HDM1

9.33e-06319195int:SMG7
InteractionITSN2 interactions

FNBP4 FASLG WASL WASF2

9.67e-06147194int:ITSN2
InteractionAPBB1 interactions

FASLG WASL VASP WASF2

2.94e-05195194int:APBB1
InteractionBAIAP2 interactions

FMNL2 WASL VASP WASF2

3.31e-05201194int:BAIAP2
InteractionABI1 interactions

RAPH1 WASL VASP WASF2

4.96e-05223194int:ABI1
InteractionPRMT2 interactions

FASLG WASL R3HDM1

8.19e-0591193int:PRMT2
InteractionACTG1 interactions

FMNL2 WHAMM WASL VASP WASF2

9.67e-05520195int:ACTG1
InteractionPSTPIP1 interactions

FASLG WASL WASF2

9.90e-0597193int:PSTPIP1
InteractionABI2 interactions

RAPH1 WASL VASP WASF2

1.30e-04286194int:ABI2
InteractionENAH interactions

RAPH1 FMNL2 VASP

2.15e-04126193int:ENAH
InteractionBAIAP2L1 interactions

FASLG FMNL2 VASP

2.30e-04129193int:BAIAP2L1
InteractionAPBB1IP interactions

VASP WASF2

2.49e-0425192int:APBB1IP
InteractionWASF2 interactions

WASL VASP WASF2

3.31e-04146193int:WASF2
InteractionSNX9 interactions

FASLG FMNL2 WASL

3.59e-04150193int:SNX9
InteractionFYB1 interactions

FASLG VASP

3.85e-0431192int:FYB1
InteractionDIAPH1 interactions

FMNL2 WASL VASP

5.72e-04176193int:DIAPH1
InteractionFYN interactions

FNBP4 FASLG WASL WASF2

6.20e-04431194int:FYN
InteractionALG13 interactions

VASP ALG13 R3HDM1

6.41e-04183193int:ALG13
InteractionARPC3 interactions

WASL VASP WASF2

6.41e-04183193int:ARPC3
InteractionJMY interactions

JMY VASP

8.88e-0447192int:JMY
InteractionNHSL1 interactions

VASP WASF2

1.00e-0350192int:NHSL1
InteractionCDC42 interactions

RAPH1 FMNL2 ZC3H4 WASL VASP WASF2

1.02e-031323196int:CDC42
InteractionMEX3B interactions

MEX3C ALG13 R3HDM1

1.12e-03222193int:MEX3B
Cytoband19q13.32

ZC3H4 VASP

4.78e-047420219q13.32
GeneFamilyWiskott-Aldrich Syndrome protein family

WHAMM JMY WASL WASF2

5.55e-101615414
CoexpressionGSE28237_FOLLICULAR_VS_LATE_GC_BCELL_DN

RAPH1 ZC3H4 VASP WASF2

1.45e-05200204M4889
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

FMNL2 HOXB4 ALG13

6.28e-05175203c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 HOXB4 PRIMA1

6.83e-05180203da723df348d7b8449bb1124f23fe6fa706412adb
ToppCelldroplet-Heart-nan-3m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 HOXB4 PRIMA1

6.83e-051802035b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX4 HOXB4 PRIMA1

6.83e-0518020350758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZFHX4 HOXB4 PCLO

8.27e-051922035f4f44f15d3a2846981e68296643a4634930a211
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZFHX4 HOXB4 PCLO

8.27e-051922035e709c0714e8eba27e03a6def0544256bedb3ced
ToppCellBac-SEP-Myeloid-CD16_Mono|Bac-SEP / Disease, Lineage and Cell Type

FMNL2 VASP WASF2

8.92e-05197203c5056605e1a61d165adba9cbee53b7cc0d41ec98
ToppCellICU-SEP-Myeloid-CD16_Mono|ICU-SEP / Disease, Lineage and Cell Type

FMNL2 VASP WASF2

9.06e-051982033e6f262ec71e99a5dadbaaeaff1b4f1894907c7d
ToppCellSepsis-ICU-SEP-Myeloid-CD16+_Monocyte|ICU-SEP / Disease, condition lineage and cell class

FMNL2 VASP WASF2

9.33e-05200203de39d94af8ef489ea347b6ecf1a39e7849f2f72e
ToppCellSepsis-Bac-SEP-Myeloid-CD16+_Monocyte|Bac-SEP / Disease, condition lineage and cell class

FMNL2 VASP WASF2

9.33e-052002034916075ec845733fc4cc1ae61964af7abcf28901
ToppCellmild-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RAPH1 FMNL2 VASP

9.33e-05200203334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

ZFHX4 RAPH1 PCLO

9.33e-05200203f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
Drugetheno-NAD

RAPH1 WASL VASP WASF2

1.88e-06104204CID005288160
DrugThimerosal

FNBP4 FMNL2 WASL VASP WASF2 PRIMA1 PCLO ALG13

4.12e-061199208ctd:D013849
DrugAC1LD8HW

FNBP4 FMNL2 VASP

3.76e-0575203CID000644061
Drugbornyl pyrophosphate

WHAMM JMY MEX3C

6.27e-0589203CID000194197
DrugC18:1n-7

WASL VASP WASF2

6.92e-0592203CID000122325
Diseasefree androgen index

FNBP4 ZFHX4 ZIC5 ZNF318

1.05e-04374204EFO_0007005
DiseaseCalcium channel blocker use measurement

WASF2 ZNF318 MEX3C

3.86e-04213203EFO_0009930
DiseaseMajor Depressive Disorder

RAPH1 PRIMA1 PCLO

5.67e-04243203C1269683
DiseaseUnipolar Depression

RAPH1 PRIMA1 PCLO

6.82e-04259203C0041696
Diseasealcohol consumption measurement

FNBP4 RAPH1 FMNL2 ZC3H4 PCLO

1.20e-031242205EFO_0007878
Diseasetestosterone measurement

FNBP4 ZFHX4 ZIC5 ZC3H4 ZNF318

1.35e-031275205EFO_0004908
Diseasegrip strength measurement

FNBP4 ZC3H4 R3HDM1

1.62e-03350203EFO_0006941
DiseaseNeurodevelopmental Disorders

ZC3H4 ALG13

1.80e-0393202C1535926
Diseaserosacea severity measurement

PCLO ALG13

4.42e-03147202EFO_0009180
DiseaseDiuretic use measurement

ZNF318 MEX3C

5.79e-03169202EFO_0009928
Diseaseage at menarche

ZFHX4 ZIC5 ZC3H4

7.17e-03594203EFO_0004703
Diseasemosquito bite reaction size measurement

FASLG R3HDM1

8.96e-03212202EFO_0008378

Protein segments in the cluster

PeptideGeneStartEntry
PPPPPPPPPPPPPPP

ALG13

921

Q9NP73
PPPPPPPPPPPPPPP

ALG13

926

Q9NP73
PPPPPPPPPPPPPPP

ALG13

931

Q9NP73
PPPPPPPPPPPLPPP

ANTXRL

401

A6NF34
PHPPPPPPPPPPPPP

R3HDM1

591

Q15032
PPLPPPPPPPPPPPP

RAPH1

626

Q70E73
PPPPPPPPPPPPPPP

RAPH1

631

Q70E73
PPPPPPPPPPPPPLP

RAPH1

636

Q70E73
PPPPPPPPPPPPPPP

JMY

811

Q8N9B5
PPPPPPPPPPPPPPP

PCLO

2406

Q9Y6V0
PPPPPPPPPPPPPPP

PCLO

2411

Q9Y6V0
PPPPPPPPPPPLPPP

PCLO

2416

Q9Y6V0
PGPPPPPPPPPPPPP

HOXB4

71

P17483
PMPPPPPPPPPPPPP

FMNL2

551

Q96PY5
PPPPPPPPPPPPPPP

FMNL2

556

Q96PY5
PPPPPPPPPPPPPLP

FMNL2

561

Q96PY5
PPPPPPPPPPPPPAP

FNBP4

906

Q8N3X1
PPPPLPPPPPPPPPP

PRIMA1

56

Q86XR5
PPPPPPPPPPPLPPP

MEX3C

21

Q5U5Q3
PPPPPPPPPPPPPPP

WHAMM

641

Q8TF30
TPPPPPPPPPPPPPP

ZFHX4

1996

Q86UP3
PPPPPPPPPPPPPPP

ZFHX4

2001

Q86UP3
PPPPPPPPLPPPPPP

FASLG

46

P48023
PPPPPPPPPPPPGPP

ZC3H4

541

Q9UPT8
PPPPPPPPPPGPPPP

WASF2

391

Q9Y6W5
PPPPPPPPGPPPPPG

WASL

376

O00401
LPPPPPPPPPPPPPP

ZNF318

1441

Q5VUA4
PPPPGPPPPPGPPPP

VASP

171

P50552
PPPPPPPPPPPPPPA

ZIC5

411

Q96T25