Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

SGCA SGCE DMD

7.54e-0520873GO:0016010
GeneOntologyCellularComponentglycoprotein complex

SGCA SGCE DMD

1.50e-0425873GO:0090665
GeneOntologyCellularComponentdendrite

PTPRZ1 PPFIA2 PPFIA1 TRPC5 CKAP5 PUM2 SGCE LMTK3 AR ASAP1 OPRD1 TPBG

2.21e-048588712GO:0030425
GeneOntologyCellularComponentdendritic tree

PTPRZ1 PPFIA2 PPFIA1 TRPC5 CKAP5 PUM2 SGCE LMTK3 AR ASAP1 OPRD1 TPBG

2.26e-048608712GO:0097447
GeneOntologyCellularComponentsarcoglycan complex

SGCA SGCE

2.54e-046872GO:0016012
GeneOntologyCellularComponentdystroglycan complex

SGCA SGCE

3.55e-047872GO:0016011
GeneOntologyCellularComponentsomatodendritic compartment

SIRT2 PTPRZ1 PPFIA2 PPFIA1 TRPC5 CKAP5 PUM2 SGCE DMD LMTK3 AR ASAP1 OPRD1 TPBG

5.21e-0412288714GO:0036477
GeneOntologyCellularComponentspine apparatus

PPFIA1 OPRD1

6.05e-049872GO:0097444
GeneOntologyCellularComponentpresynapse

DMXL2 VPS33B PPFIA4 PPFIA2 PPFIA1 TRPC5 ATM DMD GABBR2 OPRD1 TPBG

1.10e-038868711GO:0098793
GeneOntologyCellularComponentaxon

NMNAT2 SIRT2 PTPRZ1 PPFIA2 PPFIA1 TRPC5 DMD LMTK3 AR OPRD1 TPBG

1.15e-038918711GO:0030424
GeneOntologyCellularComponentsynaptic vesicle

DMXL2 VPS33B PPFIA2 ATM DMD OPRD1

1.59e-03300876GO:0008021
DomainLiprin

PPFIA4 PPFIA2 PPFIA1

1.80e-066853IPR029515
DomainSarcoglycan_2

SGCA SGCE

2.05e-052852PF05510
DomainSarcoglycan_alpha/epsilon

SGCA SGCE

2.05e-052852IPR008908
DomainCADG

SGCA SGCE

6.12e-053852SM00736
DomainCadg

SGCA SGCE

6.12e-053852IPR006644
DomainSAM_2

PPFIA4 PPFIA2 PPFIA1

9.84e-0443853PF07647
DomainF-box-like

FBXO10 FBH1 FBXW4

1.05e-0344853PF12937
Domain7TM_GPCR_Srsx

SSTR4 NPFFR1 EDNRB OPRD1

1.71e-03112854SM01381
DomainFBOX

FBXO10 FBH1 FBXW4

1.71e-0352853SM00256
DomainAcyl_Trfase/lysoPLipase

PNPLA2 PLA2G4E

2.66e-0317852IPR016035
DomainZZ

DMD NBR1

2.99e-0318852PF00569
DomainZF_ZZ_2

DMD NBR1

2.99e-0318852PS50135
DomainZF_ZZ_1

DMD NBR1

2.99e-0318852PS01357
DomainZnf_ZZ

DMD NBR1

3.33e-0319852IPR000433
DomainZnF_ZZ

DMD NBR1

3.33e-0319852SM00291
DomainF-box

FBXO10 FBH1 FBXW4

3.53e-0367853PF00646
DomainSAM_1

PPFIA4 PPFIA2 PPFIA1

3.68e-0368853PF00536
DomainFBOX

FBXO10 FBH1 FBXW4

4.33e-0372853PS50181
DomainF-box_dom

FBXO10 FBH1 FBXW4

4.85e-0375853IPR001810
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

4.78e-0517603M93
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

4.78e-0517603MM14907
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

5.72e-0518603M13015
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

5.72e-0518603MM14702
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

5.72e-0518603MM14703
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

5.72e-0518603M27043
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA2 PPFIA1

7.94e-0520603M27290
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA2 PPFIA1

7.94e-0520603MM14991
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.22e-0423603MM14852
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.22e-0423603M12627
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.39e-0424603MM14834
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.39e-0424603M630
PathwayREACTOME_TRP_CHANNELS

TRPC4AP RIPK3 TRPC5

2.23e-0428603MM14943
PathwayREACTOME_TRP_CHANNELS

TRPC4AP RIPK3 TRPC5

2.23e-0428603M27241
PathwayREACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS

MRE11 ATM

2.64e-046602M27585
PathwayREACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS

MRE11 ATM

2.64e-046602MM15295
PathwayWP_DDX1_AS_A_REGULATORY_COMPONENT_OF_THE_DROSHA_MICROPROCESSOR

MRE11 ATM

3.69e-047602M39689
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

MRE11 ATM RFC3

4.74e-0436603MM15281
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

MRE11 ATM RFC3

5.14e-0437603M27568
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

MRE11 ATM RFC3

8.01e-0443603M27588
PathwayWP_SMC1SMC3_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME

MRE11 ATM

9.56e-0411602M42562
PathwayREACTOME_PEXOPHAGY

ATM NBR1

9.56e-0411602M29846
PathwayREACTOME_PEXOPHAGY

ATM NBR1

9.56e-0411602MM15673
PathwayPID_FANCONI_PATHWAY

MRE11 ATM RFC3

1.04e-0347603M1
PathwayWP_HOMOLOGOUS_RECOMBINATION

MRE11 ATM

1.14e-0312602MM15951
PathwayKEGG_MEDICUS_REFERENCE_NAD_BIOSYNTHESIS

NMNAT2 IDO1

1.14e-0312602M47980
PathwayWP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER

MRE11 ATM AR F13B

1.22e-03110604M48043
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.32e-0351603M4281
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA4 PPFIA2 PPFIA1

1.32e-0351603MM14499
PathwayREACTOME_DISEASES_OF_DNA_REPAIR

MRE11 ATM RFC3

1.32e-0351603M29854
PathwayWP_HOMOLOGOUS_RECOMBINATION

MRE11 ATM

1.35e-0313602M39712
PathwayKEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING

MRE11 ATM

1.35e-0313602M47832
Pubmed

Combined deficiency of alpha and epsilon sarcoglycan disrupts the cardiac dystrophin complex.

SGCA SGCE DMD

1.51e-08387321890494
Pubmed

The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.

PPFIA4 PPFIA2 PPFIA1

1.51e-07587319013515
Pubmed

Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins.

PPFIA4 PPFIA2 PPFIA1

3.01e-07687321618221
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

JAK2 MRE11 RNF123 FBXO10 CYP26B1 PPFIA2 DENND4B DUSP16 CKAP5 GPAM LRRC40 ATM

3.07e-07736871229676528
Pubmed

Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

5.25e-07787311931740
Pubmed

Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

1.26e-06987312629171
Pubmed

Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.

PPFIA4 PPFIA2 PPFIA1

1.26e-06987312923177
Pubmed

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PPFIA4 PPFIA2 PPFIA1

3.27e-06128739624153
Pubmed

ATM Inhibition Potentiates Death of Androgen Receptor-inactivated Prostate Cancer Cells with Telomere Dysfunction.

ATM AR

6.19e-06287226336104
Pubmed

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.

MRE11 ATM

6.19e-06287233571423
Pubmed

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.

MRE11 ATM

6.19e-06287220647759
Pubmed

GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer.

GABBR2 AR

6.19e-06287237762034
Pubmed

The Mre11 complex is required for ATM activation and the G2/M checkpoint.

MRE11 ATM

6.19e-06287214657032
Pubmed

δ-opioid receptor and somatostatin receptor-4 heterodimerization: possible implications in modulation of pain associated signaling.

SSTR4 OPRD1

6.19e-06287224416361
Pubmed

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.

MRE11 ATM

6.19e-06287216327781
Pubmed

epsilon-Sarcoglycan, a broadly expressed homologue of the gene mutated in limb-girdle muscular dystrophy 2D.

SGCA SGCE

6.19e-0628729405466
Pubmed

Necroptosis mediates myofibre death in dystrophin-deficient mice.

RIPK3 DMD

6.19e-06287230194302
Pubmed

Epsilon-sarcoglycan compensates for lack of alpha-sarcoglycan in a mouse model of limb-girdle muscular dystrophy.

SGCA SGCE

6.19e-06287215689353
Pubmed

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.

PPFIA4 PPFIA2 PPFIA1

1.67e-052087323791195
Pubmed

Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration.

SGCA DMD

1.85e-05387229057908
Pubmed

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

MRE11 ATM

1.85e-05387226240375
Pubmed

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.

MRE11 ATM

1.85e-05387230612738
Pubmed

Overexpression of Galgt2 reduces dystrophic pathology in the skeletal muscles of alpha sarcoglycan-deficient mice.

SGCA DMD

1.85e-05387219498002
Pubmed

Colocalization of bFGF and the myogenic regulatory gene myogenin in dystrophic mdx muscle precursors and young myotubes in vivo.

FGF2 DMD

1.85e-0538727781901
Pubmed

Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.

MRE11 ATM

1.85e-05387231285322
Pubmed

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.

MRE11 ATM

1.85e-05387229101015
Pubmed

Rapid activation of ATR by ionizing radiation requires ATM and Mre11.

MRE11 ATM

1.85e-05387216431910
Pubmed

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

MRE11 ATM

1.85e-05387226280532
Pubmed

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

MRE11 ATM

1.85e-05387212861053
Pubmed

Eccentric contractions lead to myofibrillar dysfunction in muscular dystrophy.

SGCA DMD

1.85e-05387219910334
Pubmed

MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet.

SGCA DMD

1.85e-05387238205246
Pubmed

Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism.

JAK2 FGF2

1.85e-05387211940567
Pubmed

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.

MRE11 ATM

1.85e-05387228362262
Pubmed

RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.

JAK2 PUM2

1.85e-05387231595981
Pubmed

S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.

SGCA DMD

1.85e-05387224684653
Pubmed

Genetic variations in the homologous recombination repair pathway genes modify risk of glioma.

MRE11 ATM

1.85e-05387226514363
Pubmed

Is SIRT2 required for necroptosis?

SIRT2 RIPK3

1.85e-05387224572428
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

JAK2 NMNAT2 UXS1 SERPINB6 TRPC4AP CMIP GNL3L PPFIA2 ASH1L HECTD4 ARHGEF38 USP15 NBR1 AR

1.89e-051489871428611215
Pubmed

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.

MRE11 ATM

3.70e-05487214690604
Pubmed

Metabolic regulation of homologous recombination repair by MRE11 lactylation.

MRE11 ATM

3.70e-05487238128537
Pubmed

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.

MRE11 ATM

3.70e-05487218596698
Pubmed

Characterization of aquaporin-4 in muscle and muscular dystrophy.

SGCA DMD

3.70e-05487212087055
Pubmed

Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy.

SGCA DMD

3.70e-05487234078746
Pubmed

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.

MRE11 ATM

3.70e-05487228369484
Pubmed

GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.

SGCA DMD

3.70e-05487228081371
Pubmed

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis.

SGCA DMD

3.70e-05487231043586
Pubmed

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer.

ATM AR

3.70e-05487226928463
Pubmed

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

MRE11 ATM

3.70e-05487217429352
Pubmed

Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.

IDO1 DMD

3.70e-05487238181046
Pubmed

Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities.

SGCA DMD

3.70e-05487211259414
Pubmed

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

MRE11 ATM

3.70e-05487228855246
Pubmed

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.

MRE11 ATM

3.70e-05487223912341
Pubmed

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

MRE11 ATM

3.70e-05487215234984
Pubmed

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.

MRE11 ATM

3.70e-05487234648881
Pubmed

Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma.

JAK2 IDO1

3.70e-05487232951108
Pubmed

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

MRE11 ATM

3.70e-05487218256278
Pubmed

MRE11 UFMylation promotes ATM activation.

MRE11 ATM

3.70e-05487230783677
Pubmed

ATM activation in the presence of oxidative stress.

MRE11 ATM

3.70e-05487221150274
Pubmed

SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.

SIRT2 ATM

3.70e-05487238554113
Pubmed

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

MRE11 ATM

3.70e-05487215965469
Pubmed

Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

PTPRZ1 EDNRB ASAP1

3.77e-052687315890332
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

CKAP5 DMD AR

4.23e-052787318468998
Pubmed

Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.

PPFIA4 PPFIA2 PPFIA1

5.85e-053087316186258
Pubmed

Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.

SGCA DMD

6.16e-05587220019182
Pubmed

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

MRE11 ATM

6.16e-05587224220101
Pubmed

Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice.

FGF2 DMD

6.16e-05587212917328
Pubmed

Homeodomain Proteins Directly Regulate ATM Kinase Activity.

MRE11 ATM

6.16e-05587230089259
Pubmed

Lipid droplet dynamics regulate adult muscle stem cell fate.

PNPLA2 DMD

6.16e-05587235045287
Pubmed

Expression of gamma -sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex.

SGCA SGCE

6.16e-05587210993904
Pubmed

TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.

TRPC4AP TRPC5

6.16e-05587220458742
Pubmed

Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.

SGCA DMD

6.16e-05587216524571
Pubmed

A role for DEAD box 1 at DNA double-strand breaks.

MRE11 ATM

6.16e-05587218710941
Pubmed

ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

MRE11 ATM

6.16e-05587218829552
Pubmed

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

MRE11 ATM

6.16e-05587223525106
Pubmed

Distinctive serum miRNA profile in mouse models of striated muscular pathologies.

SGCA DMD

6.16e-05587223418438
Pubmed

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.

SGCE DMD

6.16e-05587217993586
Pubmed

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.

MRE11 ATM

6.16e-05587229844578
Pubmed

Analysis of variants in DNA damage signalling genes in bladder cancer.

MRE11 ATM

6.16e-05587218638378
Pubmed

Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling.

SGCA DMD

6.16e-05587219143834
Pubmed

ATM activation is impaired in human cells defective in RecQL4 helicase activity.

MRE11 ATM

6.16e-05587230594395
Pubmed

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

MRE11 ATM

6.16e-05587216905549
Pubmed

Sarcolemma-localized nNOS is required to maintain activity after mild exercise.

SGCA DMD

6.16e-05587218953332
Pubmed

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

MRE11 ATM

6.16e-05587219015239
Pubmed

Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.

FGF2 ATM

6.16e-05587230194346
Pubmed

DNA double strand break repair enzymes function at multiple steps in retroviral infection.

MRE11 ATM

6.16e-05587220003485
Pubmed

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

MRE11 ATM

6.16e-05587224534091
Pubmed

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.

MRE11 ATM RFC3

6.46e-053187326095369
Pubmed

The synaptic vesicle cycle.

PPFIA4 PPFIA2 PPFIA1

6.46e-053187315217342
Pubmed

Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex.

SGCA DMD

9.22e-05687217452335
Pubmed

DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.

MRE11 ATM

9.22e-05687218381424
Pubmed

Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies.

SGCA DMD

9.22e-05687226060189
Pubmed

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

MRE11 ATM

9.22e-05687216357220
Pubmed

Interactions between dystrophin glycoprotein complex proteins.

SGCA DMD

9.22e-0568727547961
Pubmed

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy.

SGCA DMD

9.22e-05687230463013
Pubmed

MDC1 is required for the intra-S-phase DNA damage checkpoint.

MRE11 ATM

9.22e-05687212607003
Pubmed

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

MRE11 ATM

9.22e-05687219171781
Pubmed

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

MRE11 ATM

9.22e-05687220086180
Pubmed

Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy.

SGCA DMD

9.22e-05687212189167
Pubmed

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

MRE11 ATM

9.22e-05687215790808
Pubmed

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.

MRE11 ATM

9.22e-05687225823024
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DMD NBR1

1.50e-031858291
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCL1 PLA2G4E

1.67e-0319582832
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TRPC4AP TRPC5 PLCL1 LMTK3

2.71e-03181584694
GeneFamilySterile alpha motif domain containing

PPFIA4 PPFIA2 PPFIA1

2.83e-0388583760
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2

SLCO5A1 RNF123 VPS33B PTPRZ1 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3 TPBG

7.12e-067478413Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5

SLCO5A1 VPS33B PTPRZ1 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3

5.55e-056588411Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1

SLCO5A1 VPS33B DENND4B HECTD4 FAXC DMD TPBG

6.84e-05255847Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4

SLCO5A1 RNF123 PTPRZ1 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3

1.25e-047218411Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#5

SLCO5A1 RNF123 VPS33B PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3

1.26e-047228411Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K5
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5

SLCO5A1 FBH1 PTPRZ1 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3

1.43e-047328411Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

SLCO5A1 PLEKHG4 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3

1.53e-046148410Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K1
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5

SLCO5A1 RNF123 PPFIA2 DENND4B DUSP16 HECTD4 FAXC SGCE DMD LMTK3 EDNRB

1.62e-047438411Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CMIP AEBP1 SGCA PPFIA2 DMD EDNRB

2.18e-06193876146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

UXS1 ARHGEF38 SGCE PLCL1 RFC3

2.09e-05170875269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 ZFAT IDO1 CD37 DUSP16

2.09e-05170875f3d5678669dcaed1836014cea543758b7ccc6b46
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 NAA25 IDO1 NPFFR1 OPRD1

2.53e-05177875aa56129d2d5a73a10e33b7162233a4d9337ee535
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 NAA25 IDO1 NPFFR1 OPRD1

2.53e-05177875d78a6003ce2d15d7771ae385de252eec7e3c3eea
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPFIA2 FAXC GPAM DMD EDNRB

2.53e-05177875e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 NAA25 IDO1 NPFFR1 OPRD1

2.53e-0517787570ca5b6fde2e38af1eb88a7d6e8746edba298191
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 PPFIA2 PLCL1 DMD ASAP1

2.53e-05177875a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 PPFIA2 PLCL1 DMD ASAP1

2.53e-051778753645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLCO5A1 NAA25 IDO1 PLCL1 NPFFR1

2.75e-0518087532d871738a24071b70084a7e80148a516110c78b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLCO5A1 NAA25 IDO1 PLCL1 NPFFR1

2.75e-05180875067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCellcritical-Lymphoid-NK|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AEBP1 KCNJ13 FGF2 SGCE EDNRB

2.75e-051808755abf778395392244daaec876f306ed7e4f388686
ToppCellNS-critical-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AEBP1 KCNJ13 FGF2 SGCE EDNRB

2.90e-05182875dd1c59babf7211362452e3e264009d70004d99f6
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CMIP SGCA PPFIA2 DMD EDNRB

2.97e-05183875af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SGCA DUSP16 FBXW4 PLCL1 DMD

3.13e-051858750094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCellmoderate-Lymphoid-NK|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AEBP1 KCNJ13 FGF2 SGCE EDNRB

3.13e-051858754979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 IDO1 SGCA PLCL1 NPFFR1

3.21e-05186875a558fd00053e7dd6216b01dc8e650c30cee451f1
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 IDO1 SGCA PLCL1 NPFFR1

3.21e-0518687575b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO5A1 IDO1 SGCA PLCL1 NPFFR1

3.21e-051868750c3d195077de7b4c354c127a26116438aef29244
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

3.56e-051908751121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

3.56e-05190875048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FILIP1 PPFIA2 PLCL1 DMD EDNRB

3.56e-051908751ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCellCOVID-19-Myeloid-DC1|COVID-19 / Condition, Lineage and Cell class

SLCO5A1 IDO1 DMD NPFFR1 ASAP1

3.65e-051918759e44357cdeca46d2b26124bb063c8422ef930083
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCTD19 PTPRZ1 ARHGEF38 HAS3 AR

3.74e-0519287525378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellMild-Myeloid-mDC|Mild / Condition, Lineage, Cell class and cell subclass

SLCO5A1 NAA25 IDO1 PLCL1 NPFFR1

3.74e-05192875da3952bd5c96242c15eb76678d0608ae2926a16e
ToppCellMild-Myeloid-mDC-|Mild / Condition, Lineage, Cell class and cell subclass

SLCO5A1 NAA25 IDO1 PLCL1 NPFFR1

3.74e-051928758520b3fdf4508ac66f7918da613abc928ab5832a
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLCO5A1 NAA25 SERPINB6 IDO1 NPFFR1

3.83e-0519387589c63dd5d97fbd92ea308405b7e8e630dda5158d
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLCO5A1 NAA25 SERPINB6 IDO1 NPFFR1

3.83e-051938757842f29c16fe3a289ed3861fa570430142d2363f
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AEBP1 SGCA PPFIA2 DMD EDNRB

4.02e-05195875eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell367C-Fibroblasts-Fibroblast-K_(Pericytes)|367C / Donor, Lineage, Cell class and subclass (all cells)

FILIP1 AEBP1 SGCA DMD EDNRB

4.12e-05196875c390ef0adff35111989a30dff86b7c5db1a89873
ToppCell367C-Fibroblasts-Fibroblast-K_(Pericytes)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FILIP1 AEBP1 SGCA DMD EDNRB

4.12e-051968752f76f050083483f0880639e6c34ff349caac3503
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRZ1 CKAP5 DMD RFC3 ASAP1

4.22e-0519787541bdea47b9b1f6415a866a515d1535ea942fdede
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

4.22e-0519787585a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

4.22e-05197875e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

SLCO5A1 NAA25 IDO1 PLCL1 DMD

4.22e-05197875c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FILIP1 AEBP1 SGCA SGCE DMD

4.22e-05197875da653dc7d216e202f390e5ab0245f243e3ed213b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

4.22e-051978759b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB ASAP1

4.33e-05198875a860246bcea847249a78fd2e86ed8e04371060db
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLCO5A1 FILIP1 SGCA PLCL1 EDNRB

4.33e-0519887522e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellCOVID-19-Myeloid-Migratory_DC|Myeloid / Condition, Lineage and Cell class

SLCO5A1 NAA25 IDO1 DMD NPFFR1

4.33e-0519887590f3b227cbc61c268d6d94bc9945a08d83d2d3d5
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NMNAT2 AEBP1 SGCA DMD EDNRB

4.43e-051998750a145172787f40d0fdaf21188d539ffaf7ece3e4
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NMNAT2 AEBP1 SGCA PPFIA2 DMD

4.43e-05199875c2903b1a4b91e94bbdaa909bacefe901255cf248
ToppCellBronchial-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VPS33B PTPRZ1 SGCE EDNRB

7.92e-05116874b0a3c109c5f20ab699e53bf8ab3903d102f5f315
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RNF123 ZFAT PLEKHG4 EXD2

1.59e-041398747e2c10830c3d16109cab3ed0d64b3532481e497d
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Malignant_Peripheral_Nerve_Sheath_Tumors|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

UXS1 PTPRZ1 NPFFR1 OPRD1

1.77e-04143874d1c8e15a8ae2094de2919e99188f9211b78c5abf
ToppCellNS-critical-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZFAT ZNF154 AEBP1 KCTD19

1.82e-041448740fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 SGCA PPFIA4 DMD

2.24e-041528740cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

DUSP16 DMD AR EDNRB

2.24e-04152874eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 SGCA PPFIA4 DMD

2.24e-04152874ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PPFIA4 DUSP16 CARD10 USP15

2.36e-041548749200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PPFIA4 DUSP16 CARD10 USP15

2.36e-04154874b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AEBP1 PTPRZ1 FGF2 LMTK3

2.47e-04156874bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRKD3 CD37 DEF8 ATM

2.47e-04156874203ef22eb76bd2b829b027c30af0557080f4006c
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TMX2 MRE11 BICRAL GABBR2

2.54e-041578744766f7d545bf2d775390589460677519cb92f4d5
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZFAT AEBP1 KCTD19 AR

2.73e-0416087461f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZFAT AEBP1 KCTD19 AR

2.73e-0416087434b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

SLCO5A1 IDO1 DMD ASAP1

2.79e-041618742f068ee643de2f647c289779a6624265ab9a749b
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

DMXL2 NOP14 HECTD4 BICRAL

2.99e-04164874d7053de88ef8e42cac6726a40e72f212659ee034
ToppCell368C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SLCO5A1 NAA25 IDO1 PLCL1

2.99e-0416487467c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCTD19 PTPRZ1 GPAM AR

3.21e-04167874d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCell356C-Myeloid-Dendritic-cDC_activated|356C / Donor, Lineage, Cell class and subclass (all cells)

SLCO5A1 NAA25 IDO1 PLCL1

3.21e-0416787443a9375fdbafd7450c553e4620e21537e08639dd
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD37 KCNJ13 FAXC TPBG

3.28e-04168874ce9fae8b295c668b0959d5007a8bcd401d80e258
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

TRPC5 DEF8 DMD LMO4

3.28e-0416887400646601548b0fee42ae16bfa5e93603bc7c5129
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

ZFAT AEBP1 KCTD19 AR

3.28e-04168874dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellSmart-seq2-blood_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PNPLA2 DMXL2 DENND4B USP15

3.35e-041698740ee74cc97a2db9cc16dc73424f74747afe13af90
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IDO1 GABBR2 AR EDNRB

3.35e-04169874225aec04ba762d4c55885257de03a65b63503fbb
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IDO1 GABBR2 AR EDNRB

3.35e-04169874278960f940b646a788360b1c84d641a8d169896b
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLCO5A1 FILIP1 PLCL1 DMD

3.43e-041708743f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

AEBP1 PTPRZ1 NPFFR1 TPBG

3.43e-0417087414aa86a4f526ed6986afcb28c49225522055550c
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PPFIA2 HECTD4 PLCL1 DMD

3.43e-041708745570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AEBP1 DMD NPFFR1 ASAP1

3.51e-04171874972fab891135bd755d5526cbc5a963200067b0a6
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD37 KCNJ13 FAXC TPBG

3.51e-04171874584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AEBP1 DMD NPFFR1 ASAP1

3.51e-041718742a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

SLCO5A1 NAA25 IDO1 NPFFR1

3.51e-04171874ce290930385cac35dbd21a5e91cf0f93cf3e99f8
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

ZFAT AEBP1 KCTD19 AR

3.59e-041728743ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

ZFAT AEBP1 KCTD19 AR

3.59e-04172874a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCellBac-SEP-Myeloid-cDC1|Bac-SEP / Disease, Lineage and Cell Type

SLCO5A1 IDO1 DMD ASAP1

3.66e-04173874f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP26B1 IDO1 NXPE2 EDNRB

3.66e-04173874ad9777e4ae70b11676ec735eb6db91776ca0cb19
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPFIA2 FAXC DMD EDNRB

3.66e-04173874f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC16A13 FAXC LMTK3 OPRD1

3.75e-041748742a96a4fd7d9ef05213b26103c689cf3a26968713
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLCO5A1 IDO1 KCTD19 PPFIA4

3.75e-0417487416204ff504b7b382b4d90ca35003ad5336020e07
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PLEKHG4 FAXC HAS3

3.78e-04728737877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRKD3 FBXO10 C16orf78 CARD10

3.83e-0417587443be63976da5ad0764d24d90919a77ce46068f52
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF123 CMIP HECTD4 EDNRB

3.83e-041758741d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 DMD EDNRB ASAP1

3.83e-04175874910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 DMD EDNRB ASAP1

3.83e-04175874f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 PPFIA4 PPFIA2 SSTR4

3.83e-04175874f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF123 CMIP HECTD4 EDNRB

3.83e-04175874427a7ee92fe16a90625946492062d37aa0f7235b
ToppCellB_cells-pDCs|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

DMXL2 ZFAT KCTD19 AR

3.91e-04176874ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

DMXL2 ZFAT KCTD19 AR

3.91e-04176874d6e660df92a3d7dd5732171ee623763faf108476
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AEBP1 PTPRZ1 PPFIA2 DMD

3.91e-041768749bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

AEBP1 PTPRZ1 NPFFR1 TPBG

3.91e-0417687405ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AEBP1 PTPRZ1 PPFIA2 DMD

3.91e-041768743f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellFetal_29-31_weeks-Immune-dendritic_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLCO5A1 ZFAT IDO1 KCTD19

4.00e-04177874c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SLCO5A1 NAA25 IDO1 NPFFR1

4.00e-04177874370aee11a6dc2c6f4366a13c3171f37bc5b32d65
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPRZ1 PLCL1 AR TPBG

4.08e-04178874fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

THOC1 UXS1 DUSP16 NBR1

4.08e-041788748b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD EDNRB

4.08e-04178874d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 AEBP1 DMD ASAP1

4.08e-0417887478a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UXS1 ARHGEF38 DMD NPFFR1

4.17e-04179874815b959ce8721c5ded70c0ca6e318dafc691746e
Diseasetubulin polymerization-promoting protein family member 2 measurement

KCTD19 PLEKHG4

2.51e-053862EFO_0802164
Diseaseliver cancer (implicated_via_orthology)

JAK2 MRE11

5.02e-054862DOID:3571 (implicated_via_orthology)
Diseasediastolic blood pressure, unipolar depression

NAA25 HECTD4 ULK4

9.17e-0530863EFO_0003761, EFO_0006336
Diseaseendometrial cancer (is_implicated_in)

MRE11 ATM AR

1.59e-0436863DOID:1380 (is_implicated_in)
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK2 ATM

1.75e-047862DOID:14566 (implicated_via_orthology)
Diseasestatus epilepticus (biomarker_via_orthology)

PTPRZ1 ATM DMD SSTR4

2.13e-04100864DOID:1824 (biomarker_via_orthology)
DiseaseCalcinosis

JAK2 RIPK3 DMD

2.53e-0442863C0006663
DiseaseMicrocalcification

JAK2 RIPK3 DMD

2.53e-0442863C0521174
DiseaseTumoral calcinosis

JAK2 RIPK3 DMD

2.53e-0442863C0263628
Diseasecognitive disorder (is_implicated_in)

FGF2 DMD

2.98e-049862DOID:1561 (is_implicated_in)
DiseaseThrombocytosis, Autosomal Dominant

JAK2 FGF2

2.98e-049862C3489628
DiseaseGestational Diabetes

FGF2 AR

2.98e-049862C0085207
Diseasetemporomandibular joint disorder

SGCA DMD

3.72e-0410862EFO_0005279
DiseaseCardiomyopathy, Familial Idiopathic

PNPLA2 ATM DMD

4.24e-0450863C1449563
DiseasePrenatal Exposure Delayed Effects

FGF2 ATM

5.44e-0412862C0033054
DiseaseThrombocythemia, Essential

JAK2 FGF2

5.44e-0412862C0040028
Diseaseleukemia

JAK2 ATM AR

5.62e-0455863C0023418
Diseasebreast carcinoma (is_marker_for)

MRE11 FGF2 ATM

9.58e-0466863DOID:3459 (is_marker_for)
Diseasemyocardial infarction (implicated_via_orthology)

JAK2 EDNRB OPRD1

9.58e-0466863DOID:5844 (implicated_via_orthology)
Diseaseportal hypertension (implicated_via_orthology)

JAK2 EDNRB

1.39e-0319862DOID:10762 (implicated_via_orthology)
Diseaseleukemia (implicated_via_orthology)

ASH1L ATM

1.39e-0319862DOID:1240 (implicated_via_orthology)
DiseaseAdenocarcinoma of prostate

ATM AR

1.54e-0320862C0007112
DiseaseDepressive disorder

RNF123 IDO1 FGF2 SGCE AR

1.59e-03289865C0011581
DiseaseDeep Vein Thrombosis

JAK2 F13B

1.70e-0321862C0149871
DiseaseVenous Thrombosis

JAK2 F13B

1.70e-0321862C0042487
DiseaseImmunologic Deficiency Syndromes

ATM EPG5

2.04e-0323862C0021051
Diseasemyeloproliferative disorder

JAK2 ATM

2.41e-0325862EFO_0004251
Diseasecoronary artery disease

NAA25 TRPC4AP CMIP VPS33B PPFIA1 KCNJ13 HECTD4 LRRC40 PLCL1 EPG5

2.47e-0311948610EFO_0001645
Diseaseovarian carcinoma

CMIP PTPRZ1 GPAM DMD GABBR2

2.51e-03321865EFO_0001075
DiseaseHeart valve disease

JAK2 RIPK3

2.61e-0326862C0018824

Protein segments in the cluster

PeptideGeneStartEntry
RRMKLLLGIALLAYV

UXS1

16

Q8NBZ7
YLAICGLKRLRINME

C21orf62

116

Q9NYP8
LGYLVKRLIDLEMTC

EPG5

1931

Q9HCE0
LMDILRCRGKRGYEA

CARD10

81

Q9BWT7
LLLRQGDCVYLMRDS

ASH1L

2661

Q9NR48
NVMGKLRYLSLLCLL

ADAM20

686

O43506
GRELLLLLMQYLCRE

AEBP1

631

Q8IUX7
IQRVMKYPLLLCELR

ARHGEF38

241

Q9NXL2
NSKIIMLRNDIYRCR

FBXO10

471

Q9UK96
RRALLLCNGMRYKLL

CMIP

41

Q8IY22
RMLKPEEVLSCRYLR

C16orf78

206

Q8WTQ4
TLLRIIYKNKCMRNG

EDNRB

121

P24530
TLDECGLRYLLAMRL

DMXL2

1561

Q8TDJ6
YRTAMKLRRLQKALC

DMD

3106

P11532
VCYSAGRRNLKLIME

JAK2

916

O60674
LALQMYGCRVIQKAL

PUM2

806

Q8TB72
RKYGRCMDLLIQRGL

KCTD19

896

Q17RG1
LIVVMYARIARKLCQ

NPFFR1

231

Q9GZQ6
LIKGELINLAMYCER

FAXC

311

Q5TGI0
LINLAMYCERIRRKF

FAXC

316

Q5TGI0
GSICQYLVMRAKRKL

PNPLA2

371

Q96AD5
QRLARLVLGCITMAY

IDO1

76

P14902
TKSGMILCRNDYIRL

LMO4

66

P61968
GIMCLKRLNYDRKEL

PPFIA4

1001

O75335
LRYLDCVIKEVMRLF

CYP26B1

351

Q9NR63
FLLIMEFCQLGDLKR

LMTK3

206

Q96Q04
LVVRGCLDLRYLAMR

EXD2

181

Q9NVH0
ILRMQCDRGQLKYPR

F13B

631

P05160
CKVIAPLLSQRYRRM

KCNJ13

6

O60928
QYCKRLLKGLFRQGM

PRKD3

286

O94806
IMCLRRLNYDRKELE

PPFIA1

1021

Q13136
LRMNYIKELDRIIAC

AR

831

P10275
MRILKRFLACIQLLC

PTPRZ1

1

P23471
AALARLYCRMALLNI

HECTD4

2441

Q9Y4D8
GLALLKRCVLMYGSL

NOP14

691

P78316
VCYGLMLLRLRSVRL

OPRD1

231

P41143
LVKRIPESRICYMLG

PLA2G4E

561

Q3MJ16
RAPRLKCQELLNYIM

ATM

111

Q13315
RKDVRAILNRMCLVY

CKAP5

1306

Q14008
CIAVLLYAMREKGIN

FBH1

386

Q8NFZ0
KGMYTLLARCEELER

BORCS6

316

Q96GS4
RTQAMLNKYRCLLLE

BICRAL

766

Q6AI39
LNKYRCLLLEDAMRI

BICRAL

771

Q6AI39
LYLGCQRDVLNKELM

DUSP16

166

Q9BY84
RGNGTRLIMRCMKYL

GLYATL1B

241

A0A0U1RQE8
RRLFQLQMCEYLIKV

ASAP1

211

Q9ULH1
LLLICSYLDMRALGR

FBXW4

36

P57775
RQDILLMKPYFITCR

DEF8

371

Q6ZN54
LRFMACLLKGYRVFL

DENND4B

571

O75064
RCLRKNLLAAMEGYI

GABBR2

301

O75899
CANRYLAMKEDGRLL

FGF2

211

P09038
ALLMLYLAIIARRCG

HAS3

526

O00219
KELRCLLGLYFGMLL

CD37

81

P11049
GMESLELLYLRRNKL

LRRC40

241

Q9H9A6
RTSLQYGIMCLKRLN

PPFIA2

1071

O75334
AGKKTRIMCILRELY

RFC3

46

P40938
LYESRKRGMLENCIL

SDHAF2

71

Q9NX18
LRYSVIMGKRACIQL

OR10J3

131

Q5JRS4
MCLVVVSDRRLYLLK

STK11IP

826

Q8N1F8
VLYVLCVLLMGRQRN

TRPC4AP

391

Q8TEL6
TYRRMLEQLLLAEKC

FILIP1

161

Q7Z7B0
EMGFCDRQLNLRLLK

NBR1

926

Q14596
NINDCLERKLIYLMG

NXPE2

351

Q96DL1
RMGKYALLLQELARA

PLEKHG4

866

Q58EX7
LMRVLGNYCRLGEVR

GNL3L

236

Q9NVN8
IRMLRKNYGCVRVDF

GPAM

386

Q9HCL2
LAMLQERRCLYVVLT

SLCO5A1

111

Q9H2Y9
YLLRMANRLFGEKSC

SERPINB6

86

P35237
AIGLCYLLIVGKMRA

SSTR4

226

P31391
FMRLLKDKGLLLRCY

SIRT2

151

Q8IXJ6
LELLRKYCMGDRPVQ

MRE11

76

P49959
LFLILAYIMCCRREG

SGCE

331

O43556
LLLAYVMCCRREGRL

SGCA

306

Q16586
FRLDIRMGLLYITLC

TMX2

106

Q9Y320
YIRALKMGCRSVELD

PLCL1

431

Q15111
LCLMTREGKRQLLYD

ZFAT

391

Q9P243
CGKRYKRRLNLDIIL

ZNF223

461

Q9UK11
RRIYCGLGLLQMIES

SLC16A13

336

Q7RTY0
LLCRLLKEVVLGMFY

RIPK3

116

Q9Y572
LMLRCTKGREYIKVV

PYROXD1

436

Q8WU10
DCLKQLMMSLLRLYR

RNF123

376

Q5XPI4
LYNLLLLRMCRYVKI

USP15

606

Q9Y4E8
LTCAYPEKMRNRVLL

TPBG

321

Q13641
GRMLLDILKFLFIYC

TRPC5

511

Q9UL62
RCLYRDVMLENLALL

ZNF154

36

Q13106
LCFLVRPRIKNMRYI

VPS33B

81

Q9H267
AGKNYLLRMCNDLLR

THOC1

131

Q96FV9
IYNREMLLLSCQARL

ULK4

761

Q96C45
AQFKLLLVRIYCMLG

NAA25

506

Q14CX7
MRYEEIELRILLLCG

NMNAT2

186

Q9BZQ4