Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	ATP8B3 ABCC4 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 UBA3 ATP10B MSH5 ABCA7 MOV10L1 AFG3L2 MYO15A DDX39B DYNC1H1 PIF1	2.20e-07	614	137	18	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP8B3 ABCC4 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 ATP10B ABCA7 MOV10L1 AFG3L2 DDX39B DYNC1H1 PIF1	3.80e-07	441	137	15	GO:0016887
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF33 PRAMEF10 UBA3 PRAMEF17 PRAMEF18 CRY1 TAF1 TAF1L	4.55e-05	187	137	8	GO:0016922
GeneOntologyMolecularFunction	pyrophosphatase activity	ATP8B3 ABCC4 ENPP2 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 ATP10B ABCA7 MOV10L1 AFG3L2 PLPP4 DDX39B DYNC1H1 PIF1	6.28e-05	839	137	17	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATP8B3 ABCC4 ENPP2 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 ATP10B ABCA7 MOV10L1 AFG3L2 PLPP4 DDX39B DYNC1H1 PIF1	6.38e-05	840	137	17	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATP8B3 ABCC4 ENPP2 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 ATP10B ABCA7 MOV10L1 AFG3L2 PLPP4 DDX39B DYNC1H1 PIF1	6.38e-05	840	137	17	GO:0016818
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	ZSWIM8 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	2.52e-04	82	137	5	GO:1990756
GeneOntologyMolecularFunction	ABC-type bile acid transporter activity	ABCC4 ABCC11	2.78e-04	4	137	2	GO:0015432
GeneOntologyMolecularFunction	ATPase-coupled organic acid transmembrane transporter activity	ABCC4 ABCC11	2.78e-04	4	137	2	GO:0033283
GeneOntologyMolecularFunction	ATPase-coupled monocarboxylic acid transmembrane transporter activity	ABCC4 ABCC11	2.78e-04	4	137	2	GO:0033285
GeneOntologyMolecularFunction	ATPase-coupled carboxylic acid transmembrane transporter activity	ABCC4 ABCC11	2.78e-04	4	137	2	GO:0033284
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATP8B3 ABCC4 SMCHD1 DHX38 NVL PEX6 PSMC4 ABCC11 ATP10B ABCA7 MOV10L1 AFG3L2 DDX39B DYNC1H1 PIF1	2.85e-04	775	137	15	GO:0017111
GeneOntologyMolecularFunction	magnesium ion binding	ATP8B3 TSSK6 RPS6KA4 CILK1 ATP10B NT5C1B MOV10L1 PIF1	3.10e-04	247	137	8	GO:0000287
GeneOntologyMolecularFunction	ubiquitin-modified protein reader activity	ANKRD13D ANKRD13B PEX6	3.31e-04	20	137	3	GO:0140036
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD8 RGPD3	3.31e-04	20	137	3	GO:0061665
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	4.61e-04	5	137	2	GO:0061628
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	ZSWIM8 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	4.99e-04	95	137	5	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	5.51e-04	55	137	4	GO:0042974
GeneOntologyMolecularFunction	modification-dependent protein binding	ANKRD13D ANKRD13B KDM5A PEX6 DZIP3 TAF1 TAF1L	5.57e-04	206	137	7	GO:0140030
GeneOntologyMolecularFunction	ubiquitin-like protein reader activity	ANKRD13D ANKRD13B PEX6	6.51e-04	25	137	3	GO:0140035
GeneOntologyMolecularFunction	collagen receptor activity	DDR2 OSCAR	6.88e-04	6	137	2	GO:0038064
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	AADACL4 ENPP2 BAAT PNPLA3 ABHD12 VARS1	7.57e-04	157	137	6	GO:0052689
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	ABCC4 ABCC11 SLC13A3 SLC1A4	8.17e-04	61	137	4	GO:1901682
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8B3 ATP10B ABCA7	9.13e-04	28	137	3	GO:0140326
GeneOntologyMolecularFunction	glutathione transmembrane transporter activity	ABCC4 SLC13A3	9.59e-04	7	137	2	GO:0034634
GeneOntologyMolecularFunction	ABC-type glutathione S-conjugate transporter activity	ABCC4 ABCC11	1.27e-03	8	137	2	GO:0015431
GeneOntologyMolecularFunction	alcohol transmembrane transporter activity	ABCC4 MFSD10	1.27e-03	8	137	2	GO:0015665
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	ABCC4 SLC13A3 SLC1A4	1.48e-03	33	137	3	GO:0072349
GeneOntologyMolecularFunction	tripeptide transmembrane transporter activity	ABCC4 SLC13A3	1.63e-03	9	137	2	GO:0042937
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCC4 ABCC11	1.63e-03	9	137	2	GO:0034040
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	TAF1 TAF1L	1.63e-03	9	137	2	GO:0001181
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP8B3 ABCA7	1.63e-03	9	137	2	GO:0090556
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD8 RGPD3	1.91e-03	36	137	3	GO:0019789
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	SH3PXD2B SH3PXD2A	2.03e-03	10	137	2	GO:0016176
GeneOntologyMolecularFunction	L-aspartate transmembrane transporter activity	SLC13A3 SLC1A4	2.03e-03	10	137	2	GO:0015183
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC4 ABCC11	2.03e-03	10	137	2	GO:0043225
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX38 MOV10L1 DDX39B PIF1	2.24e-03	80	137	4	GO:0008186
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	PRAMEF33 PRAMEF10 UBA3 PRAMEF17 PRAMEF18 CRY1 TAF1 TAF1L TRIB1	2.37e-03	417	137	9	GO:0061629
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RGPD8 RGPD3 RGPD5	8.07e-06	20	136	4	GO:0006607
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD8 RGPD3	2.29e-05	9	136	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD8 RGPD3	3.25e-05	10	136	3	GO:1903301
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RANGAP1 RGPD8 RGPD3	1.32e-07	8	140	4	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RANGAP1 RGPD8 RGPD3	3.92e-07	10	140	4	GO:0044614
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	ZSWIM8 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18 ZER1	6.94e-07	47	140	6	GO:0031462
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RANGAP1 RGPD8 RGPD3	1.06e-05	21	140	4	GO:0106068
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD8 RGPD3	1.01e-04	14	140	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD8 RGPD3	2.23e-04	18	140	3	GO:0044615
GeneOntologyCellularComponent	transferase complex	ATG5 RGPD4 UBR2 ZSWIM8 PRAMEF33 RANGAP1 PRAMEF10 RGPD8 RPN1 POLR2B PRAMEF17 PRAMEF18 CCNB2 RGPD3 ZER1 TAF1 TAF1L	2.48e-04	963	140	17	GO:1990234
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD8 RGPD3	3.08e-04	20	140	3	GO:0042405
GeneOntologyCellularComponent	inclusion body	RGPD4 RANGAP1 RGPD8 PSMC4 RGPD3	3.49e-04	90	140	5	GO:0016234
GeneOntologyCellularComponent	nuclear pore	RGPD4 RANGAP1 RGPD8 RGPD3 RGPD5	5.93e-04	101	140	5	GO:0005643
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD4 RGPD8 LIG3 RGPD3	6.37e-06	16	111	4	MP:0003701
Domain	Grip	RGPD4 RGPD8 GCC2 RGPD3 RGPD5	7.58e-09	11	133	5	SM00755
Domain	GRIP	RGPD4 RGPD8 GCC2 RGPD3 RGPD5	7.58e-09	11	133	5	PF01465
Domain	GRIP_dom	RGPD4 RGPD8 GCC2 RGPD3 RGPD5	1.29e-08	12	133	5	IPR000237
Domain	GRIP	RGPD4 RGPD8 GCC2 RGPD3 RGPD5	1.29e-08	12	133	5	PS50913
Domain	Rab_bind	RGPD4 RGPD8 GCC2 RGPD3	8.46e-08	7	133	4	PF16704
Domain	GCC2_Rab_bind	RGPD4 RGPD8 GCC2 RGPD3	8.46e-08	7	133	4	IPR032023
Domain	-	RGPD4 RGPD8 GCC2 RGPD3	4.99e-07	10	133	4	1.10.220.60
Domain	Ran_BP1	RGPD4 RGPD8 RGPD3 RGPD5	1.16e-06	12	133	4	PF00638
Domain	RANBD1	RGPD4 RGPD8 RGPD3 RGPD5	1.16e-06	12	133	4	PS50196
Domain	RanBD	RGPD4 RGPD8 RGPD3 RGPD5	1.67e-06	13	133	4	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD8 RGPD3 RGPD5	1.67e-06	13	133	4	IPR000156
Domain	AAA	ABCC4 NVL PEX6 PSMC4 ABCC11 ABCA7 AFG3L2 DYNC1H1	8.94e-06	144	133	8	SM00382
Domain	AAA+_ATPase	ABCC4 NVL PEX6 PSMC4 ABCC11 ABCA7 AFG3L2 DYNC1H1	8.94e-06	144	133	8	IPR003593
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	5.03e-05	2	133	2	IPR022591
Domain	CCM2_C	CCM2 CCM2L	5.03e-05	2	133	2	IPR032375
Domain	TBP-binding	TAF1 TAF1L	5.03e-05	2	133	2	PF09247
Domain	CCM2_C	CCM2 CCM2L	5.03e-05	2	133	2	PF16545
Domain	DUF3591	TAF1 TAF1L	5.03e-05	2	133	2	PF12157
Domain	Malcavernin	CCM2 CCM2L	5.03e-05	2	133	2	IPR026159
Domain	TAF_II_230-bd	TAF1 TAF1L	5.03e-05	2	133	2	IPR009067
Domain	-	TAF1 TAF1L	5.03e-05	2	133	2	1.10.1100.10
Domain	TAF1_animal	TAF1 TAF1L	5.03e-05	2	133	2	IPR011177
Domain	ATPase_AAA_CS	NVL PEX6 PSMC4 AFG3L2	5.08e-05	29	133	4	IPR003960
Domain	AAA	NVL PEX6 PSMC4 AFG3L2	9.66e-05	34	133	4	PS00674
Domain	-	ABCC4 DHX38 NVL PEX6 PSMC4 ABCC11 MSH5 TEP1 ABCA7 MOV10L1 AFG3L2 MYO15A DDX39B DYNC1H1 PIF1	2.79e-04	746	133	15	3.40.50.300
Domain	-	GTF2IRD2B GTF2IRD2	2.99e-04	4	133	2	3.90.1460.10
Domain	GPCR_chapero_1	ANKRD13D ANKRD13B	2.99e-04	4	133	2	PF11904
Domain	GTF2I	GTF2IRD2B GTF2IRD2	2.99e-04	4	133	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	2.99e-04	4	133	2	PF02946
Domain	ANKRD13	ANKRD13D ANKRD13B	2.99e-04	4	133	2	IPR021832
Domain	GTF2I	GTF2IRD2B GTF2IRD2	2.99e-04	4	133	2	IPR004212
Domain	PRAME_family	PRAMEF10 PRAMEF17 PRAMEF18	3.15e-04	19	133	3	IPR026271
Domain	-	FLII RANGAP1 PRAMEF10 PRAMEF17 PRAMEF18 LRRC42 LRFN2 ZER1 SCRIB	4.93e-04	321	133	9	3.80.10.10
Domain	AAA	NVL PEX6 PSMC4 AFG3L2	5.11e-04	52	133	4	PF00004
Domain	L_dom-like	FLII RANGAP1 PRAMEF10 PRAMEF17 PRAMEF18 LRRC42 LRFN2 ZER1 SCRIB	5.76e-04	328	133	9	IPR032675
Domain	ATPase_AAA_core	NVL PEX6 PSMC4 AFG3L2	5.90e-04	54	133	4	IPR003959
Domain	P-loop_NTPase	ABCC4 DHX38 NVL PEX6 PSMC4 ABCC11 MSH5 TEP1 ABCA7 MOV10L1 AFG3L2 MYO15A DDX39B DYNC1H1 PIF1	1.05e-03	848	133	15	IPR027417
Domain	Hydrolase_3	ATP8B3 ATP10B	2.18e-03	10	133	2	PF08282
Domain	ABC_transporter_CS	ABCC4 ABCC11 ABCA7	3.31e-03	42	133	3	IPR017871
Domain	P_typ_ATPase_c	ATP8B3 ATP10B	4.33e-03	14	133	2	IPR032630
Domain	P-type_ATPase_N	ATP8B3 ATP10B	4.33e-03	14	133	2	IPR032631
Domain	P-type_ATPase_IV	ATP8B3 ATP10B	4.33e-03	14	133	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8B3 ATP10B	4.33e-03	14	133	2	PF16212
Domain	PhoLip_ATPase_N	ATP8B3 ATP10B	4.33e-03	14	133	2	PF16209
Domain	SH3	TNK1 STAC3 TXK SH3PXD2B SH3PXD2A MYO15A	4.53e-03	216	133	6	SM00326
Domain	SH3	TNK1 STAC3 TXK SH3PXD2B SH3PXD2A MYO15A	4.53e-03	216	133	6	PS50002
Domain	ABC_tran	ABCC4 ABCC11 ABCA7	4.83e-03	48	133	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCC4 ABCC11 ABCA7	4.83e-03	48	133	3	PS50893
Domain	SH3_domain	TNK1 STAC3 TXK SH3PXD2B SH3PXD2A MYO15A	4.95e-03	220	133	6	IPR001452
Domain	ABC_TRANSPORTER_1	ABCC4 ABCC11 ABCA7	5.12e-03	49	133	3	PS00211
Domain	ABC_transporter-like	ABCC4 ABCC11 ABCA7	5.42e-03	50	133	3	IPR003439
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RANGAP1 RGPD8 RGPD3	6.76e-06	18	100	4	MM1549
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD8 RGPD3 RGPD5	8.72e-09	7	140	4	15710750
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD8 MMP28 RGPD3	3.12e-08	9	140	4	28100513
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RANGAP1 RGPD8 RGPD3	5.18e-08	10	140	4	27160050
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RANGAP1 RGPD8 RGPD3	8.12e-08	11	140	4	34110283
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RGPD4 FLII RANGAP1 ILF2 RGPD8 COPA RPN1 POLR2B PSMC4 C15orf39 TSC2 METTL13 PPP3CB RGPD3 AFG3L2 SCRIB DDX39B VARS1 DYNC1H1 RGPD5	1.68e-07	1257	140	20	37317656
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 CYLD FLII RANGAP1 ILF2 RGPD8 KDM5A MINK1 TSC2 SH3PXD2B PPP3CB FAM120A TMEM259 RGPD3 DZIP3 SCRIB DYNC1H1	3.69e-07	963	140	17	28671696
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	1.16e-06	20	140	4	26694250
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	1.74e-06	22	140	4	31729367
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD4 RANGAP1 RGPD8 RGPD3	1.74e-06	22	140	4	27717094
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD8 RGPD3	2.21e-06	7	140	3	20682751
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	2.98e-06	25	140	4	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF10 PRAMEF17 PRAMEF18 DPPA5	2.98e-06	25	140	4	12620990
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	RGPD4 RANGAP1 ILF2 RGPD8 COPA RPN1 SMCHD1 NVL PSMC4 RBM25 RGPD3 VARS1 DYNC1H1	3.17e-06	665	140	13	30457570
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD8 RGPD3	3.52e-06	8	140	3	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD8 RGPD3	3.52e-06	8	140	3	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD8 RGPD3	3.52e-06	8	140	3	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD8 RGPD3	3.52e-06	8	140	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD8 RGPD3	3.52e-06	8	140	3	21310149
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RGPD4 CYLD FLII RANGAP1 STIM2 RGPD8 RPN1 MINK1 PSMC4 SLC1A4 HSPA12A RGPD3 AFG3L2 TMEM35A ABHD12 DDX39B VARS1	3.60e-06	1139	140	17	36417873
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	RANGAP1 ILF2 COPA RPN1 POLR2B PSMC4 TSC2 SCRIB DDX39B VARS1 DYNC1H1 RGPD5	3.71e-06	571	140	12	37167062
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATG5 CYLD FLII ZSWIM8 COPA KDM5A ENPP2 UBA3 TSC2 P4HTM PPP3CB FAM120A SACS TAF1 SCRIB ABHD12 VARS1 DYNC1H1	4.39e-06	1285	140	18	35914814
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	4.78e-06	28	140	4	25089626
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	9733766
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD8 RGPD3	5.27e-06	9	140	3	17887960
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD4 RANGAP1 STIM2 RGPD8 COPA KDM5A RPN1 SMCHD1 ATP10B TRIM16 GTF2IRD2B SACS SH3PXD2A RGPD3 GTF2IRD2 CFAP74 DDX39B VARS1 RGPD5	5.61e-06	1442	140	19	35575683
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	6.35e-06	30	140	4	38786026
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FLII RANGAP1 ILF2 RPS6KA4 COPA RRP1B RPN1 POLR2B METTL13 RBM25 FAM120A SCRIB DDX39B VARS1 DYNC1H1	7.13e-06	949	140	15	36574265
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	UBR2 NEMP1 ABCC4 FRAS1 STIM2 NAAA COPA RPN1 TSC2 EXT1 PLXND1 ABCA7 PTGS1 P4HTM TMEM259 SCRIB ABHD12	7.23e-06	1201	140	17	35696571
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD8 RGPD3	7.50e-06	10	140	3	8857542
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD8 RGPD3	7.50e-06	10	140	3	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD8 RGPD3	7.50e-06	10	140	3	21859863
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	FRAS1 ILF2 RGPD8 RRP1B RPN1 SMCHD1 DDR2 SLC1A4 LRRC42 SH3PXD2A RGPD3	7.92e-06	513	140	11	25798074
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ATG5 FLII RANGAP1 ILF2 COPA RPN1 SMCHD1 POLR2B DHX38 PSMC4 LIG3 METTL13 FAM120A AFG3L2 SCRIB DDX39B VARS1 DYNC1H1	8.88e-06	1353	140	18	29467282
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD8 RGPD3	1.03e-05	11	140	3	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD8 RGPD3	1.03e-05	11	140	3	17069463
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD13D FLII FRAS1 PEX6 C15orf39 TSC2 PLXND1 TEP1 ABCA7 PPP1R26 SH3PXD2B TMEM259 PCNX4 ZER1 TRIB1 DYNC1H1	1.04e-05	1105	140	16	35748872
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	1.20e-05	35	140	4	19389355
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLII ILF2 RPS6KA4 COPA RRP1B RPN1 SMCHD1 POLR2B DHX38 LAMA3 RBM25 PPP3CB FAM120A AFG3L2 SCRIB DDX39B DYNC1H1	1.30e-05	1257	140	17	36526897
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.61e-05	2	140	2	11687802
Pubmed	Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.	ABCC4 ABCC11	1.61e-05	2	140	2	12133003
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	1.61e-05	2	140	2	38804708
Pubmed	The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.	SH3PXD2B SH3PXD2A	1.61e-05	2	140	2	27802184
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	1.61e-05	2	140	2	10070062
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	1.61e-05	2	140	2	22842574
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.61e-05	2	140	2	34910522
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	1.61e-05	2	140	2	27571988
Pubmed	Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON).	ABCC4 ABCC11	1.61e-05	2	140	2	34951141
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	1.61e-05	2	140	2	34403156
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	1.61e-05	2	140	2	15388857
Pubmed	Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins.	ABCC4 PTGS1	1.61e-05	2	140	2	20530583
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII RANGAP1 ILF2 COPA RRP1B SMCHD1 POLR2B LIG3 RBM25 SACS AFG3L2 SCRIB DDX39B VARS1 DYNC1H1	1.74e-05	1024	140	15	24711643
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD8 RGPD3	1.77e-05	13	140	3	31427429
Pubmed	Human transcription factor protein interaction networks.	CYLD NEMP1 ILF2 ESS2 COPA RRP1B KDM5A RPN1 SMCHD1 PSMC4 C15orf39 LIG3 RBM25 FAM120A TAF1 TAF1L TRIB1 DYNC1H1	1.84e-05	1429	140	18	35140242
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	RRP1B TSC2 PPP1R26 SACS DZIP3	1.86e-05	80	140	5	19389623
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NEMP1 RANGAP1 ILF2 COPA RRP1B KDM5A RPN1 SMCHD1 POLR2B DHX38 LIG3 RBM25 CCNB2 RGPD3 AFG3L2 TAF1L DDX39B	1.89e-05	1294	140	17	30804502
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RRP1B SMCHD1 DHX38 NVL LIG3 TAF1 TAF1L DDX39B	2.06e-05	283	140	8	30585729
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ILF2 ESS2 COPA RRP1B KDM5A RPN1 SMCHD1 POLR2B DHX38 PSMC4 METTL13 RBM25 FAM120A AFG3L2 DDX39B VARS1 DYNC1H1	2.38e-05	1318	140	17	30463901
Pubmed	The protein interaction landscape of the human CMGC kinase group.	RANGAP1 RPS6KA4 RRP1B POLR2B CILK1 CCM2 RBM25 CCNB2 AFG3L2 SCRIB DDX39B VARS1	2.62e-05	695	140	12	23602568
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ATP8B3 UBR2 STIM2 DCDC2C AADACL4 SLC22A23 MDGA2 TSC2 EXT1 LRFN2 MOV10L1 MYO15A TRIB1	2.70e-05	814	140	13	23251661
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RGPD8 RGPD3	2.80e-05	15	140	3	14697343
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NEMP1 RANGAP1 COPA HGH1 RPN1 POLR2B PSMC4 TSC2 TMEM259 CCNB2 SCRIB ABHD12 VARS1 DYNC1H1	2.88e-05	942	140	14	31073040
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FLII RANGAP1 ILF2 COPA POLR2B DHX38 PSMC4 METTL13 RGPD3 SCRIB DDX39B DYNC1H1	2.97e-05	704	140	12	29955894
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CYLD IBA57 FRAS1 RANGAP1 STIM2 ILF2 RRP1B RPN1 POLR2B MINK1 NVL PSMC4 HSPA12A FAM120A SACS AFG3L2 SCRIB ABHD12	3.11e-05	1487	140	18	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FLII NEMP1 IBA57 STIM2 ILF2 ESS2 RGPD8 COPA RRP1B RPN1 POLR2B PEX6 PSMC4 TSC2 FAM120A AFG3L2 SECISBP2 DDX39B	3.37e-05	1496	140	18	32877691
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CYLD FLII RANGAP1 COPA KDM5A MINK1 SH3PXD2B FAM120A SH3PXD2A SECISBP2 DDX39B VARS1	3.90e-05	724	140	12	36232890
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF10 PRAMEF17 PRAMEF18	4.17e-05	17	140	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF10 PRAMEF17 PRAMEF18	4.17e-05	17	140	3	37781892
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CYLD UBR2 FRAS1 UNC5A LRFN2 GCC2 DZIP3 SCRIB DYNC1H1	4.28e-05	407	140	9	12693553
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	UBR2 FLII RANGAP1 ILF2 COPA RRP1B RPN1 POLR2B PSMC4 LIG3 RBM25 FAM120A AFG3L2 DDX39B VARS1 DYNC1H1	4.47e-05	1247	140	16	27684187
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	UBR2 NEMP1 RANGAP1 ESS2 COPA KDM5A LIG3 METTL13 FAM120A SCRIB TRIB1 VARS1 DYNC1H1	4.57e-05	857	140	13	25609649
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	4.81e-05	3	140	2	30801007
Pubmed	Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.	SH3PXD2B SH3PXD2A	4.81e-05	3	140	2	25259869
Pubmed	COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells.	ABCC4 PTGS1	4.81e-05	3	140	2	19399588
Pubmed	Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits.	PNPLA3 TRIB1	4.81e-05	3	140	2	24785259
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	4.81e-05	3	140	2	16822332
Pubmed	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	SH3PXD2B SH3PXD2A	4.81e-05	3	140	2	20609497
Pubmed	Laforin, the most common protein mutated in Lafora disease, regulates autophagy.	ATG5 TSC2	4.81e-05	3	140	2	20453062
Pubmed	The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.	PTGS1 HCAR3	4.81e-05	3	140	2	24845831
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	4.81e-05	3	140	2	15100712
Interaction	RGPD2 interactions	RGPD4 NEMP1 RANGAP1 RGPD8 RGPD3 RGPD5	1.95e-08	27	133	6	int:RGPD2
Interaction	RGPD4 interactions	RGPD4 RGPD8 RGPD3 RGPD5	1.21e-05	22	133	4	int:RGPD4
Interaction	RGPD1 interactions	RGPD4 RANGAP1 RGPD8 RGPD3 RGPD5	1.75e-05	49	133	5	int:RGPD1
Cytoband	1p36.21	PRAMEF33 PRAMEF10 AADACL4 PRAMEF17 PRAMEF18	1.44e-06	63	139	5	1p36.21
Cytoband	10q26.12	HSPA12A PLPP4	1.89e-04	7	139	2	10q26.12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF33 PADI4 PRAMEF10 AADACL4 PRAMEF17 PRAMEF18 CFAP74 MDS2	1.16e-03	681	139	8	chr1p36
Cytoband	2q13	RGPD8 RGPD3 RGPD5	1.18e-03	68	139	3	2q13
Cytoband	9q22.2	SECISBP2 CTSV	1.20e-03	17	139	2	9q22.2
Cytoband	2q12.3	RGPD4 GCC2	1.20e-03	17	139	2	2q12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2q12	RGPD4 GCC2 RGPD3	2.02e-03	82	139	3	chr2q12
Cytoband	15q15.3	STRC STRCP1	2.61e-03	25	139	2	15q15.3
GeneFamily	AAA ATPases	NVL PEX6 PSMC4 AFG3L2	1.52e-04	53	92	4	413
GeneFamily	PRAME family	PRAMEF10 PRAMEF17 PRAMEF18	2.39e-04	24	92	3	686
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RRP1B TSC2 PPP1R17 PPP1R26 SACS DZIP3	3.24e-04	181	92	6	694
GeneFamily	ATP binding cassette subfamily C	ABCC4 ABCC11	1.93e-03	13	92	2	807
GeneFamily	ATPase phospholipid transporting	ATP8B3 ATP10B	2.58e-03	15	92	2	1210
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD8 RGPD3 RGPD5	2.82e-03	115	92	4	769
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CYLD FRAS1 SMCHD1 TXK RBM25 GCC2 DDX39B	2.90e-06	197	139	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	NEMP1 ESS2 CLHC1 TXK PCNX4 TMEM35A	5.21e-06	140	139	6	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	NEMP1 ZSWIM8 BAAT ATP10B MYO15A	5.23e-06	80	139	5	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.93e-05	2	130	2	DOID:0110471 (implicated_via_orthology)
Disease	fructose-1,6-bisphosphatase 1 measurement	PCNX4 PNPLA3	2.86e-04	6	130	2	EFO_0801606
Disease	Disproportionate short stature	DDR2 CILK1 EXT1 SH3PXD2B	3.80e-04	77	130	4	C0878659
Disease	Amelogenesis imperfecta local hypoplastic form	LAMA3 ACP4	3.99e-04	7	130	2	C0399367
Disease	neurodegenerative disease (implicated_via_orthology)	UBR2 PSMC4 SLC1A4 AFG3L2 DYNC1H1	4.68e-04	145	130	5	DOID:1289 (implicated_via_orthology)
Disease	phosphatidylcholine 36:0 measurement	NVL TRIB1	6.80e-04	9	130	2	EFO_0021473
Disease	epilepsy (implicated_via_orthology)	MINK1 SLC13A3 SLC1A4 KCNA5 DYNC1H1	7.94e-04	163	130	5	DOID:1826 (implicated_via_orthology)
Disease	cyclic adenosine monophosphate measurement	ABCC4 NT5C1B	2.51e-03	17	130	2	EFO_0010473
Disease	Stevens-Johnson syndrome, toxic epidermal necrolysis	SLC22A23 DDX39B	2.51e-03	17	130	2	EFO_0004276, EFO_0004775
Disease	Familial Progressive Myoclonic Epilepsy	SACS AFG3L2	2.51e-03	17	130	2	C0751777
Disease	Atypical Inclusion-Body Disease	SACS AFG3L2	2.51e-03	17	130	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	SACS AFG3L2	2.51e-03	17	130	2	C0751778
Disease	Biotin-Responsive Encephalopathy	SACS AFG3L2	2.51e-03	17	130	2	C0751780
Disease	May-White Syndrome	SACS AFG3L2	2.51e-03	17	130	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	SACS AFG3L2	2.51e-03	17	130	2	C0751781
Disease	RS-warfarin measurement	STIM2 AADACL4 UNC5A TMEM259	2.52e-03	128	130	4	EFO_0803325
Disease	neutrophil count, eosinophil count	UBR2 RBPMS RPN1 ABCA7 TRIB1	2.58e-03	213	130	5	EFO_0004833, EFO_0004842
Disease	lymphocyte percentage of leukocytes	ATG5 UBR2 RBPMS RPN1 MINK1 ABCA7 GTF2IRD2B GTF2IRD2 TRIB1	2.80e-03	665	130	9	EFO_0007993
Disease	Action Myoclonus-Renal Failure Syndrome	SACS AFG3L2	2.81e-03	18	130	2	C0751779
Disease	DiGeorge syndrome (implicated_via_orthology)	ESS2 PLXND1	3.14e-03	19	130	2	DOID:11198 (implicated_via_orthology)
Disease	neutrophil count, basophil count	UBR2 RBPMS RPN1 ABCA7 TRIB1	3.20e-03	224	130	5	EFO_0004833, EFO_0005090
Disease	Intellectual Disability	KDM5A PEX6 SLC1A4 P4HTM SACS TAF1 DYNC1H1	3.74e-03	447	130	7	C3714756
Disease	Headache, HbA1c measurement	DDR2 PLXND1	3.83e-03	21	130	2	EFO_0004541, HP_0002315
Disease	saturated fatty acids to total fatty acids percentage	PNPLA3 TRIB1	3.83e-03	21	130	2	EFO_0022305
Disease	free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	PNPLA3 TRIB1	3.83e-03	21	130	2	EFO_0022277
Disease	total blood protein measurement	ATG5 ZSWIM8 RBPMS DHX38 RFX8 SH3PXD2A TRIB1	3.84e-03	449	130	7	EFO_0004536

Protein segments in the cluster

Peptide	Gene	Start	Entry
LREVRQPKRIFFGPV	PRAMEF33	441	A0A0G2JMD5
ILTPGPAFRFVKALQ	NT5C1B	346	Q96P26
KVREGRLRGALFLPP	BAAT	141	Q14032
FAKLRDFITLRLPPG	ANKRD13D	391	Q6ZTN6
PALLRPGRFDRQIFI	AFG3L2	461	Q9Y4W6
RKGKVFREPLFLDLP	CTSV	101	O60911
GFRDFLLKPELLRAI	DDX39B	46	Q13838
RKRLFPVRFLDPLPT	IBA57	276	Q5T440
LPGIFPKDVRSIREL	C17orf78	31	Q8N4C9
DLRFGTIPVRLFQPK	AADACL4	91	Q5VUY2
ILAGSQRFREKFPPV	CAPN13	411	Q6MZZ7
RKFLLLGLRPFIPEK	CCM2	346	Q9BSQ5
TFPVLALRVIFPALK	ATP8B3	1201	O60423
RLLKAIFGPDGSRIP	DPPA5	31	A6NC42
RPFIQKLFRPVAADG	ATG5	196	Q9H1Y0
GFVSPIRRLVFPKAG	CCM2L	11	Q9NUG4
LQKPDRKLFGFRLPS	ATP10B	966	O94823
ILGKLLFAPDTPFTR	ABCA7	291	Q8IZY2
RTLSLKPLLFEIPGF	P4HTM	136	Q9NXG6
TFLAFPSPEKLLRLG	RANGAP1	436	P46060
LFVSGLPLDIKPREL	RBPMS	26	Q93062
KEDIFRRFPVAPLIP	RBM25	241	P49756
FLKPGSERERLLPVI	RGPD5	1721	Q99666
FLKPGSERERLLPVI	RGPD8	1721	O14715
DPAILRPGRLDKTLF	NVL	731	O15381
LDTALGKPREVFRLP	NUDCD1	91	Q96RS6
LPRILREFLGKSEPE	ABHD12	381	Q8N2K0
AKLRDFITLRLPPGF	ANKRD13B	401	Q86YJ7
LSFVPAPDRKGFRLL	PADI4	476	Q9UM07
LPLEKRAPSIALGFR	MFSD10	226	Q14728
LREVRQPKRIFFGPI	PRAMEF17	441	Q5VTA0
PLKGTSLDPRFVFLL	FLII	636	Q13045
FFELRRPPQHGVLLK	FRAS1	1631	Q86XX4
RRVGDKDLPVLAPFT	MOV10L1	706	Q9BXT6
LGPEFKLVFSIRPRS	LAMA3	3176	Q16787
GKVVLELERFLPQPF	NAAA	81	Q02083
RIRKEGFPVRLPFQG	MYO15A	1826	Q9UKN7
FLKDLEPPIVARFVR	DDR2	151	Q16832
PVFLGRALAAPRVKL	FER1L4	846	A9Z1Z3
FLKRFPQTVLGGPRF	PCNX4	16	Q63HM2
VFPLSLQLKGRPARF	PLXND1	821	Q9Y4D7
PALLRPGRFDKLVFV	PEX6	856	Q13608
IRRFDPKLFLVFLLG	NEMP1	156	O14524
LLSRAFVPPDLKVLG	PNPLA3	221	Q9NST1
LREVREPKRIFFGPV	PRAMEF18	441	Q5VWM3
FDRPEVLRKKPGSLF	ABCC11	1356	Q96J66
LPIVGKAFIRPFREH	PEDS1	106	A5PLL7
PVKIIDFGFARLRPQ	RPS6KA4	546	O75676
PRPFRLFPKGFSVEL	LRRC42	41	Q9Y546
PEDGPFLKALLFELR	AP5M1	46	Q9H0R1
LAFRKNRLPPEFSPV	FAM120A	626	Q9NZB2
FGLDPAVIKVRRSPL	HSPA12A	521	O43301
LARRFLLRRKFIPDP	PTGS1	176	P23219
GHPLFLRRKPVLSFQ	LIG3	46	P49916
GFVRRKEIILFPPCE	MDS2	91	Q8NDY4
IKLIVGRPRPDFFYR	PLPP4	101	Q5VZY2
LGRPLVKESFFRPIL	DZIP3	966	Q86Y13
DPLSFIGRIRPLAEK	KDM5A	31	P29375
PRLEGEKARLLSPVF	MDGA2	806	Q7Z553
RFGLFKPGEIAPLLF	OSCAR	61	Q8IYS5
LKAPVLFFDRNPIGR	ABCC4	806	O15439
ALPEGPLVFVALVFR	ACP4	26	Q9BZG2
IFLKPGSERERLLPV	RGPD3	1721	A6NKT7
GPAFKILEPGRRERL	ESS2	341	Q96DF8
LGDPAKRLRYFDPLR	KCNA5	146	P22460
GERGFLKFNTIPPLR	EXT1	246	Q16394
ELKFELGRPLPLHFL	CCNB2	256	O95067
DPPRIVLDKLERRGF	GCHFR	51	P30047
FTNGRLFIPPAKIII	DCDC2C	141	A8MYV0
AATFARRLLELGPKP	COPA	1121	P53621
PKQPFLKRGEGLARF	CENPJ	371	Q9HC77
IRGQPADVFPRLFKE	CRY1	76	Q16526
FIFLKPGSERERLLP	GCC2	1626	Q8IWJ2
LLKDLRIRFPGFEPL	ILF2	226	Q12905
LFSLPLDVPFSGLRK	CYP26C1	221	Q6V0L0
LLRAFEKDRFPGIPA	DUX3	136	Q96PT4
PPAFRRLFEFFVLLK	TMEM259	61	Q4ZIN3
VNLLRAGRIFVFEPP	DYNC1H1	4136	Q14204
KFPGVVRFRGPLLAE	CYLD	141	Q9NQC7
KFRPVPGSALQIFEL	METTL13	211	Q8N6R0
AAEFIKFTVIRPLPG	GTF2IRD2	396	Q86UP8
AAEFIKFTVIRPLPG	GTF2IRD2B	396	Q6EKJ0
IRRLDRFKEPPAFGP	PPP3CB	221	P16298
VFALPPKEGRCLFVI	SLC13A3	31	Q8WWT9
VIRAPKLFPVAFNLV	SEC14L4	191	Q9UDX3
FPSLEGRFILDNLKP	SACS	701	Q9NZJ4
SLLPQEFGFVRLPKF	CFAP74	946	Q9C0B2
FVRPPLIIFSVDGFR	ENPP2	161	Q13822
FKRFLRIQRLFPPVP	CSF2RA	346	P15509
VGPRKPFFERLRRLE	PTX4	31	Q96A99
EVVKLLPFLAPGARA	HGH1	21	Q9BTY7
PGRPADFVLLKERTL	MINK1	796	Q8N4C8
ALFFPPLRRLILFKG	MMP28	421	Q9H239
KRPEIIFLPSVDFGL	MSH5	126	O43196
FLRTLRLKLAAAPGP	PIF1	116	Q9H611
PPFLGLPRFEARKAV	VARS1	626	P26640
IFLKPGSERERLLPV	RGPD4	1721	Q7Z3J3
DTPFLPKPLFFRRAK	RRP1B	646	Q14684
FKPIGDPVFARDLLT	SMCHD1	1801	A6NHR9
IEFPLPDRRQKRLIF	PSMC4	331	P43686
LYALRIELCPPGKRF	SLC22A23	301	A1A5C7
VTELFPEFRPGKVLR	TAF1L	246	Q8IZX4
PEFRPGKVLRFLHLF	TAF1L	251	Q8IZX4
VTELFPEFRPGKVLR	TAF1	226	P21675
PEFRPGKVLRFLRLF	TAF1	231	P21675
PFRLLGKRSLPEGVA	ITIH3	26	Q06033
FRDDFIAKVLPPVLG	HCAR3	21	P49019
RFFTVKLPVALDPGA	RPN1	111	P04843
KRLDLAGPLLAFLFR	POLR2B	391	P30876
LSADVKPFVPRFAGL	SECISBP2	16	Q96T21
LGVQKEFAFRKPPRL	PPP1R26	281	Q5T8A7
LPKPFFRLLNLRKLG	SCRIB	51	Q14160
LAKRLLAPELFGEVP	STRC	846	Q7RTU9
IADFGLAREIRSKPP	CILK1	141	Q9UPZ9
RGKPLPLLLFFEALF	CLHC1	341	Q8NHS4
FRKFKILRPAPLPAA	C15orf39	651	Q6ZRI6
PFAAGVTLLRDERPK	PPP1R17	126	O96001
RQFLFRPKDIGRPKA	UBA3	111	Q8TBC4
IIPFRALKRPLQFLG	ZER1	316	Q7Z7L7
LLFPATRGVPAKRLL	TRIB1	21	Q96RU8
LVFPRPGQTLRFKVV	ZP1	51	P60852
FVLQPKDPGVLSFLR	TEP1	2426	Q99973
LKALDVVLFGPLTRP	STIM2	196	Q9P246
TRKNPFRFLLGLLAP	SLC1A4	321	P43007
IIPFLPGKILFRRSH	SH3PXD2A	71	Q5TCZ1
RIIPFLPGKILFRRS	SH3PXD2B	71	A1X283
PATFGKLVRLVFPDL	RFX8	61	Q6ZV50
LREVRQPKRIFFGPV	PRAMEF10	441	O60809
NLVPPFLDGRIVFTK	DHX38	411	Q92620
PIRLFGLIRAKREPI	TRAT1	171	Q6PIZ9
ALVGPSAFKIPFLIR	UNC5A	746	Q6ZN44
KTLERLFPGFRPAVE	ZSWIM8	466	A7E2V4
KPEGRPTFAELLRAV	TXK	506	P42681
PRTIKVADFGLVRPL	TNK1	256	Q13470
RRAPPDFVNKFLPRE	TSSK6	46	Q9BXA6
PLKAGPFRRLGVYID	TRIM16	486	O95361
LAKRLLAPELFGEVP	STRCP1	846	A6NGW2
EKVGFFPPNFIIRVR	STAC3	291	Q96MF2
LQLPEGFRPDFRPKI	UBR2	1281	Q8IWV8
RLPFRKDFVPFITKG	TSC2	901	P49815
KGLLFVPPDIDRRTV	LRFN2	41	Q9ULH4
KLPLRLRIFEKFPNR	NALCN	626	Q8IZF0
LVPGRPKDVANFFLL	TMEM35A	81	Q53FP2