Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription factor binding

GTF2A1 NCOA6 TOB2 ARNT MED12L TFDP3 TACC2 RUNX1 TRIM24 NFAT5 DCP1A

1.60e-067534911GO:0008134
GeneOntologyMolecularFunctiontranscription coregulator activity

MED15 KMT2C NCOA6 TOB2 MED12L DYRK1A WWTR1 TRIM24

6.11e-05562498GO:0003712
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

GTF2A1 NCOA6 TOB2 ARNT TFDP3 TACC2 TRIM24

6.64e-05417497GO:0061629
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

GTF2A1 NCOA6 TOB2 ARNT TFDP3 TACC2 RUNX1 TRIM24

7.80e-05582498GO:0140297
GeneOntologyMolecularFunctiontranscription coactivator activity

KMT2C NCOA6 MED12L DYRK1A WWTR1 TRIM24

9.39e-05303496GO:0003713
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SOX6 GTF2A1 ARNT LMX1B TFDP3 CC2D1A CHD7 RUNX1 TRIM24 MGA NFAT5 RFX2

1.61e-0414594912GO:0000977
GeneOntologyMolecularFunctionmolecular adaptor activity

MED15 KMT2C NCOA6 TOB2 IGF2BP1 NELFA MED12L DYRK1A OTUD4 WWTR1 TRIM24

3.60e-0413564911GO:0060090
GeneOntologyMolecularFunctionco-SMAD binding

TRIM33 USP9X

3.83e-0412492GO:0070410
GeneOntologyMolecularFunctionchromatin binding

TRIM33 NCOA6 TOX4 NELFA CHD7 RUNX1 TRIM24 NFAT5

3.98e-04739498GO:0003682
GeneOntologyMolecularFunctionprotein dimerization activity

SOX6 AMELY GTF2A1 ARNT NOD1 SRM WWTR1 ODC1 RUNX1 MGA

5.85e-0412054910GO:0046983
GeneOntologyMolecularFunctionK63-linked deubiquitinase activity

USP9X OTUD4

6.93e-0416492GO:0061578
GeneOntologyMolecularFunctionprotein homodimerization activity

SOX6 AMELY ARNT NOD1 SRM WWTR1 ODC1 RUNX1

7.60e-04815498GO:0042803
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

NCOA6 TOB2

8.80e-0418492GO:0042809
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SOX6 ARNT TFDP3 CC2D1A CHD7 RUNX1 TRIM24 MGA NFAT5 RFX2

8.85e-0412714910GO:0000987
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

TRIM33 CHD7 RUNX1

1.11e-0383493GO:1990841
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA6 TOB2 TACC2 TRIM24

1.14e-03187494GO:0016922
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED15 KMT2C NCOA6 TOB2 IGF2BP1 MED12L DYRK1A WWTR1 TRIM24

1.83e-031160499GO:0030674
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SOX6 ARNT CC2D1A CHD7 RUNX1 TRIM24 MGA NFAT5 RFX2

2.94e-031244499GO:0000978
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

SOX6 MED15 TET2 KMT2C GTF2A1 NCOA6 ARNT LMX1B NELFA CAPRIN2 MED12L TFDP3 WWTR1 CHD7 POGZ RUNX1 MGA NFAT5 RFX2

1.99e-1013905019GO:0045944
GeneOntologyCellularComponenttranscription regulator complex

SOX6 MED15 GTF2A1 NCOA6 ARNT TFDP3 WWTR1 RUNX1 MGA NFAT5 DCP1A

1.26e-075965011GO:0005667
GeneOntologyCellularComponentchromatin

SOX6 TRIM33 EXOSC10 ARNT TOX4 LMX1B TFDP3 CHD7 POGZ RUNX1 TRIM24 MGA NFAT5 RFX2

6.23e-0614805014GO:0000785
GeneOntologyCellularComponentnuclear protein-containing complex

MED15 KMT2C GTF2A1 NCOA6 EXOSC10 ARNT TINF2 NELFA MED12L TFDP3 RUNX1 MGA

7.41e-0513775012GO:0140513
GeneOntologyCellularComponentMLL3/4 complex

KMT2C NCOA6

3.64e-0412502GO:0044666
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

MED15 GTF2A1 ARNT TFDP3 RUNX1

4.72e-04272505GO:0090575
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C NCOA6 MGA

7.70e-0475503GO:0035097
HumanPhenoJuvenile aseptic necrosis

FN1 TINF2 LMX1B DYRK1A

1.93e-0543204HP:0100323
HumanPhenoSacrococcygeal pilonidal abnormality

NELFA USP9X RTTN DYRK1A ODC1

6.09e-05114205HP:0010767
HumanPhenoAbnormal finger morphology

SOX6 TET2 KMT2C FN1 TINF2 LMX1B NELFA USP9X RTTN MED12L DYRK1A CHD7 POGZ ODC1

7.87e-0513852014HP:0001167
HumanPhenoLong fingers

SOX6 KMT2C NELFA USP9X MED12L DYRK1A ODC1

1.04e-04306207HP:0100807
HumanPhenoReduced impulse control

SOX6 TET2 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1 RUNX1

1.12e-0410322012HP:5200045
HumanPhenoAbnormality of the palpebral fissures

SOX6 KMT2C LMX1B NELFA USP9X RTTN MED12L DYRK1A CHD7 POGZ ODC1

1.42e-048802011HP:0008050
HumanPhenoNarrow mouth

SOX6 LMX1B RTTN MED12L CHD7 POGZ

1.98e-04234206HP:0000160
HumanPhenoIncreased proportion of CD25+ mast cells

TET2 RUNX1

2.18e-046202HP:0031408
HumanPhenoAbnormal serum mast cell beta-tryptase concentration

TET2 RUNX1

2.18e-046202HP:0031900
HumanPhenoElevated total serum tryptase

TET2 RUNX1

2.18e-046202HP:0031901
HumanPhenoAbnormal thorax morphology

SOX6 TET2 KMT2C FN1 LMX1B NELFA RTTN MED12L DYRK1A CHD7 POGZ ODC1 DYSF

2.81e-0413282013HP:0000765
HumanPhenoIntellectual disability, severe

LMX1B SOBP NELFA RTTN DYRK1A CC2D1A POGZ

3.47e-04371207HP:0010864
HumanPhenoAbnormal sacrum morphology

NELFA USP9X RTTN DYRK1A ODC1

3.71e-04167205HP:0005107
HumanPhenoDisinhibition

SOX6 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1

3.81e-048072010HP:0000734
HumanPhenoInappropriate behavior

SOX6 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1

3.81e-048072010HP:0000719
HumanPhenoAbnormal response to social norms

SOX6 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1

3.81e-048072010HP:5200123
HumanPhenoSocial disinhibition

SOX6 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1

3.81e-048072010HP:5200029
HumanPhenoAvascular necrosis

FN1 TINF2 LMX1B DYRK1A

3.87e-0492204HP:0010885
HumanPhenoAbnormal basophil morphology

TET2 RUNX1

4.04e-048202HP:0001912
HumanPhenoAnaphylactic shock

TET2 RUNX1

4.04e-048202HP:0100845
HumanPhenoAbnormal mast cell morphology

TET2 RUNX1

4.04e-048202HP:0100494
HumanPhenoAbdominal cramps

TET2 RUNX1

4.04e-048202HP:0032155
HumanPhenoAggressive behavior

KMT2C USP9X RTTN MED12L DYRK1A CHD7 POGZ ODC1

4.39e-04516208HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

KMT2C USP9X RTTN MED12L DYRK1A CHD7 POGZ ODC1

4.39e-04516208HP:0006919
HumanPhenoBudd-Chiari syndrome

TET2 TINF2

5.19e-049202HP:0002639
HumanPhenoIris coloboma

NELFA MED12L DYRK1A CHD7 POGZ

5.66e-04183205HP:0000612
HumanPhenoHypermetropia

KMT2C SOBP USP9X MED12L DYRK1A POGZ

6.12e-04288206HP:0000540
HumanPhenoAbnormal soft palate morphology

SOX6 KMT2C USP9X DYRK1A CHD7 POGZ

6.23e-04289206HP:0100736
HumanPhenoDuodenal atresia

RTTN DYRK1A CHD7

6.61e-0445203HP:0002247
HumanPhenoAbnormal midface morphology

KMT2C FN1 TINF2 LMX1B SOBP NELFA CHD7 POGZ ODC1

7.05e-04704209HP:0000309
HumanPhenoAbnormally increased volition

SOX6 KMT2C USP9X RTTN MED12L DYRK1A CC2D1A CHD7 POGZ ODC1

7.05e-048692010HP:5200263
HumanPhenoSacral dimple

NELFA USP9X DYRK1A ODC1

7.64e-04110204HP:0000960
HumanPhenoBroad chin

LMX1B DYRK1A

7.89e-0411202HP:0011822
MousePhenosmall tectum

LMX1B DYRK1A

9.68e-062442MP:0006105
MousePhenolethality during fetal growth through weaning, incomplete penetrance

SOX6 TET2 GTF2A1 NCOA6 IGF2BP1 LMX1B DYRK1A CC2D1A WWTR1 CHD7 POGZ RUNX1 NFAT5

2.69e-0511244413MP:0011112
MousePhenoprenatal growth retardation

TRIM33 NCOA6 IGF2BP1 ARNT TOX4 FN1 RTTN DYRK1A TFDP3 CHD7 DCP1A

5.79e-058694411MP:0010865
MousePhenoembryonic growth retardation

TRIM33 NCOA6 ARNT TOX4 FN1 RTTN DYRK1A TFDP3 CHD7 DCP1A

1.01e-047634410MP:0003984
MousePhenodecreased superior colliculus size

LMX1B DYRK1A

1.44e-046442MP:0002892
MousePhenoperinatal lethality, incomplete penetrance

SOX6 TET2 GTF2A1 NCOA6 IGF2BP1 LMX1B CC2D1A WWTR1

1.50e-04503448MP:0011090
MousePhenomyeloid hyperplasia

TET2 TINF2 RUNX1

1.63e-0434443MP:0010373
MousePhenodecreased embryo size

TRIM33 NCOA6 ARNT FN1 USP9X RTTN DYRK1A TFDP3 DCP1A

1.75e-04659449MP:0001698
MousePhenoabnormal embryo development

TRIM33 NCOA6 EXOSC10 ARNT TOX4 FN1 LMX1B USP9X RTTN DYRK1A TFDP3 CHD7 DCP1A

2.07e-0413704413MP:0001672
MousePhenoabnormal parietal lobe morphology

DYRK1A CHD7 POGZ

2.10e-0437443MP:0000794
MousePhenoembryonic lethality during organogenesis

NCOA6 ARNT FN1 RTTN DYRK1A TFDP3 CHD7 POGZ RUNX1 DCP1A

3.12e-048764410MP:0006207
MousePhenoabnormal trophoblast giant cell morphology

NCOA6 ARNT TFDP3 MGA

3.36e-04106444MP:0005033
MousePhenoabnormal mural trophectoderm morphology

NCOA6 ARNT TFDP3 MGA

3.48e-04107444MP:0012057
MousePhenoanemia

TET2 IGF2BP1 FN1 POGZ RUNX1 NFAT5

3.67e-04306446MP:0001577
MousePhenoprenatal lethality, incomplete penetrance

KMT2C NCOA6 ARNT FN1 GOLGA6C DYRK1A WWTR1 CHD7 POGZ

4.44e-04747449MP:0011101
MousePhenoabnormal fetal cardiomyocyte proliferation

NCOA6 CHD7 NFAT5

4.56e-0448443MP:0003567
MousePhenoabnormal prenatal growth/weight/body size

TRIM33 NCOA6 IGF2BP1 ARNT TOX4 FN1 USP9X RTTN DYRK1A TFDP3 CHD7 POGZ DCP1A

4.84e-0414934413MP:0004196
DomainHMG_box

SOX6 KMT2C TOX4

3.62e-0453493PF00505
Domainp53-like_TF_DNA-bd

RUNX1 MGA NFAT5

3.62e-0453493IPR008967
DomainHMG

SOX6 KMT2C TOX4

3.83e-0454493SM00398
DomainHMG_box_dom

SOX6 KMT2C TOX4

6.61e-0465493IPR009071
DomainBbox_C

TRIM33 TRIM24

6.93e-0415492IPR003649
DomainBBC

TRIM33 TRIM24

6.93e-0415492SM00502
DomainPHD

TRIM33 KMT2C TRIM24

1.00e-0375493PF00628
DomainZnf_PHD-finger

TRIM33 KMT2C TRIM24

1.17e-0379493IPR019787
DomainPHD

TRIM33 KMT2C TRIM24

1.64e-0389493SM00249
DomainZnf_PHD

TRIM33 KMT2C TRIM24

1.75e-0391493IPR001965
DomainZF_PHD_2

TRIM33 KMT2C TRIM24

1.98e-0395493PS50016
DomainZF_PHD_1

TRIM33 KMT2C TRIM24

2.04e-0396493PS01359
DomainBROMODOMAIN_1

TRIM33 TRIM24

4.24e-0337492PS00633
DomainBromodomain

TRIM33 TRIM24

4.46e-0338492PF00439
DomainBROMODOMAIN_2

TRIM33 TRIM24

5.18e-0341492PS50014
DomainBROMO

TRIM33 TRIM24

5.43e-0342492SM00297
DomainBromodomain

TRIM33 TRIM24

5.43e-0342492IPR001487
Domain-

TRIM33 TRIM24

5.43e-03424921.20.920.10
DomainZnf_FYVE_PHD

TRIM33 KMT2C TRIM24

6.75e-03147493IPR011011
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

TRIM33 USP9X WWTR1

7.11e-0531373M669
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

USP9X TFDP3 WWTR1

1.66e-0441373MM14876
Pubmed

Human transcription factor protein interaction networks.

SOX6 MED15 TET2 TRIM33 KMT2C NCOA6 IGF2BP1 ARNT SOBP USP9X OTUD4 CC2D1A R3HDM2 CHD7 POGZ TRIM24 MGA DCP1A

5.18e-131429501835140242
Pubmed

Interaction network of human early embryonic transcription factors.

MED15 TET2 TRIM33 KMT2C NCOA6 ARNT SOBP CHD7 POGZ TRIM24 MGA

2.49e-12351501138297188
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED15 TET2 TRIM33 KMT2C NCOA6 EXOSC10 IGF2BP1 ARNT NELFA SRM CC2D1A CHD7 POGZ RUNX1 TRIM24

2.39e-111103501534189442
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MED15 TET2 TRIM33 NCOA6 EXOSC10 NELFA CHD7 TRIM24 MGA

1.59e-1026850933640491
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MED15 KMT2C NCOA6 EXOSC10 TOX4 USP9X CC2D1A WWTR1 POGZ MGA DCP1A

2.94e-10549501138280479
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

TRIM33 GTF2A1 EXOSC10 TOX4 NELFA TFDP3 POGZ TRIM24 MGA

1.26e-0933950930415952
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

MED15 TET2 TRIM33 KMT2C DYRK1A CHD7 POGZ TRIM24 MGA

5.09e-0939850935016035
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

KMT2C NCOA6 EXOSC10 YIPF5 ARNT TOX4 TINF2 WWTR1 CHD7 POGZ SLFN5 RUNX1 MGA

2.43e-081294501330804502
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

MED15 TET2 GTF2A1 ARNT SOBP R3HDM2

8.56e-0815250638360978
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ARNT LMX1B DYRK1A OTUD4 CHD7 POGZ RUNX1 MGA NFAT5

1.34e-0758350929844126
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TET2 TOX4 TFDP3 CHD7 POGZ TRIM24 MGA DCP1A

1.41e-0741850834709266
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED15 TRIM33 KMT2C USP9X POGZ MGA

1.49e-0716750620362541
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

SOX6 GTF2A1 ARNT TOX4 TFDP3 POGZ TRIM24 MGA NFAT5 RFX2

1.92e-07808501020412781
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

MED15 TRIM33 ARNT NELFA TACC2 TRIM24 MGA DCP1A

2.22e-0744450834795231
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

KMT2C GTF2A1 ARNT TOX4 TFDP3 TACC2 POGZ NFAT5 DCP1A

6.87e-0770950922988430
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

TRIM33 EXOSC10 TOX4 DYRK1A POGZ TRIM24 MGA

7.74e-0735750737059091
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

KMT2C NCOA6 TOX4 TINF2 POGZ

8.07e-0711950523508102
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

TRIM33 NCOA6 EXOSC10 IGF2BP1 TOX4 TINF2 CHD7 POGZ TRIM24 MGA

8.74e-07954501036373674
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

TRIM33 CHD7 POGZ TRIM24 MGA

1.03e-0612550532891193
Pubmed

Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells.

TRIM33 TRIM24

2.03e-06250232932986
Pubmed

Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif.

TRIM33 TRIM24

2.03e-06250222123502
Pubmed

T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway.

RUNX1 NFAT5

2.03e-06250224310293
Pubmed

TAZ suppresses NFAT5 activity through tyrosine phosphorylation.

WWTR1 NFAT5

2.03e-06250223045390
Pubmed

Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.

TET2 KMT2C

2.03e-06250226880370
Pubmed

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0.

TET2 RUNX1

2.03e-06250227997762
Pubmed

Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.

IGF2BP1 RUNX1

2.03e-06250235179253
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

KMT2C EXOSC10 FN1 DYRK1A OTUD4 TACC2 CHD7 MGA NFAT5 DCP1A

2.75e-061084501011544199
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

SOX6 TRIM33 USP9X CHD7 SLFN5 RUNX1

3.17e-0628250623667531
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

GTF2A1 NCOA6 EXOSC10 TOX4 CHD7 MGA

3.24e-0628350630585729
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TRIM33 ARNT DYRK1A WWTR1 POGZ TRIM24 MGA RFX2 DCP1A

3.25e-0685750925609649
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

MED15 TRIM33 KMT2C NCOA6 ARNT WWTR1 TRIM24

3.96e-0645750732344865
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX6 ARNT TOX4 LMX1B TFDP3 RUNX1 MGA NFAT5 RFX2

5.20e-0690850919274049
Pubmed

RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.

IGF2BP1 RUNX1

6.07e-06350237670323
Pubmed

The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.

TRIM33 TRIM24

6.07e-06350210439047
Pubmed

Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.

TRIM33 TRIM24

6.07e-06350212096914
Pubmed

Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains.

TRIM33 TRIM24

6.07e-06350236098557
Pubmed

RUNX1 regulates SMAD1 by transcriptionally activating the expression of USP9X, regulating the activation of hepatic stellate cells and liver fibrosis.

USP9X RUNX1

6.07e-06350233933467
Pubmed

Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.

TRIM33 TRIM24

6.07e-06350236430693
Pubmed

Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.

KMT2C NCOA6

6.07e-06350218372346
Pubmed

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis.

KMT2C NCOA6

6.07e-06350221330447
Pubmed

IGF2BP1 expression in human mesenchymal stem cells significantly affects their proliferation and is under the epigenetic control of TET1/2 demethylases.

TET2 IGF2BP1

6.07e-06350224915579
Pubmed

ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.

IGF2BP1 RUNX1

6.07e-06350226852652
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA6 CHD7 POGZ TRIM24

6.39e-068350428794006
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

GTF2A1 TOX4 TINF2 USP9X CHD7

9.55e-0619750520811636
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TET2 TRIM33 KMT2C NCOA6 CAPRIN2 MED12L POGZ

1.03e-0552950714621295
Pubmed

KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.

TRIM33 TRIM24

1.21e-05450234392614
Pubmed

Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts.

TET2 RUNX1

1.21e-05450223065512
Pubmed

TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage.

TRIM33 TRIM24

1.21e-05450224820418
Pubmed

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.

TRIM33 TRIM24

1.21e-05450221531907
Pubmed

Feedforward loop between IMP1 and YAP/TAZ promotes tumorigenesis and malignant progression in glioblastoma.

IGF2BP1 WWTR1

1.21e-05450236308276
Pubmed

Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome.

TET2 RUNX1

1.21e-05450232341038
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

TRIM33 TOB2 IGF2BP1 USP9X DYRK1A OTUD4 CC2D1A POGZ DCP1A

1.51e-05103850926673895
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

TRIM33 NELFA POGZ TRIM24 MGA

1.70e-0522250537071664
Pubmed

TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding.

AMELY FN1

2.02e-05550217699513
Pubmed

Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis.

TRIM33 USP9X

2.02e-05550228115363
Pubmed

HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells.

ARNT USP9X

2.02e-05550234592152
Pubmed

TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.

TRIM33 TRIM24

2.02e-05550210022127
Pubmed

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

MED15 WWTR1

2.02e-05550218568018
Pubmed

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.

USP9X OTUD4 MGA

2.46e-053950325944111
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TOB2 OTUD4 R3HDM2 LRRC7 POGZ NFAT5

2.55e-0540750612693553
Pubmed

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

TRIM33 USP9X

3.03e-05650219135894
Pubmed

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.

CHD7 RUNX1

3.03e-05650232883883
Pubmed

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.

WWTR1 RUNX1

3.03e-05650211118213
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C NCOA6

3.03e-05650217021013
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

SOX6 GTF2A1 ARNT LMX1B NELFA WWTR1 TRIM24 RFX2

3.33e-0587750820211142
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

TRIM33 NELFA TRIM24 MGA

4.23e-0513450425452129
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C NCOA6

4.23e-05750219433796
Pubmed

Runx1 and Runx2 cooperate during sternal morphogenesis.

SOX6 RUNX1

4.23e-05750220181744
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C NCOA6

4.23e-05750219556342
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

MED15 KMT2C NCOA6

4.62e-054850327703004
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

KMT2C CHD7 POGZ MGA

5.91e-0514650423892456
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

EXOSC10 FN1 USP9X OTUD4 NFAT5 DCP1A

6.01e-0547550631040226
Pubmed

Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.

NCOA6 ARNT TFDP3

6.59e-055450319228596
Pubmed

A human MAP kinase interactome.

KMT2C GTF2A1 TOX4 WWTR1 POGZ MGA

6.82e-0548650620936779
Pubmed

TBR1 regulates autism risk genes in the developing neocortex.

DYRK1A POGZ

7.25e-05950227325115
Pubmed

Mga is essential for the survival of pluripotent cells during peri-implantation development.

ODC1 MGA

7.25e-05950225516968
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

IGF2BP1 NELFA USP9X OTUD4 CC2D1A TACC2

8.23e-0550350616964243
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

KMT2C NCOA6 TRIM24

8.59e-055950328813667
Pubmed

A fibronectin gradient remodels mixed-phase mesoderm.

FN1 WWTR1

9.05e-051050239028807
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

KMT2C ARNT NOD1 TINF2 NELFA USP9X DYRK1A SRM MGA

1.02e-04132750932694731
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

YIPF5 USP9X DYRK1A OTUD4 CC2D1A

1.07e-0432750515592455
Pubmed

Functional consequences of necdin nucleocytoplasmic localization.

SOBP WWTR1 POGZ

1.10e-046450322442722
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCOA6 NELFA OTUD4 CHD7 POGZ RUNX1 DCP1A

1.14e-0477450715302935
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

MED15 NCOA6 MGA

1.15e-046550322496869
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

MED15 TRIM33 ARNT

1.20e-046650323275444
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

TRIM33 USP9X TRIM24 DCP1A

1.30e-0417950436261009
Pubmed

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

USP9X RUNX1

1.32e-041250223861879
Pubmed

Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture.

FN1 WWTR1

1.32e-041250230883226
Pubmed

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.

TRIM33 TRIM24

1.32e-041250230479348
Pubmed

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.

TET2 RUNX1

1.32e-041250220678218
Pubmed

Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

DYRK1A RUNX1

1.32e-041250227100087
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

TET2 EXOSC10 IGF2BP1 USP9X OTUD4 MGA

1.35e-0455150634728620
Pubmed

ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.

TET2 RUNX1

1.56e-041350220880116
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C NCOA6

1.56e-041350217761849
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2C NCOA6 LMX1B RTTN SNX8 DYRK1A CC2D1A DYSF

1.66e-04110550835748872
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

TFDP3 POGZ MGA

1.69e-047450329795351
Pubmed

Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1.

LMX1B RUNX1

1.82e-041450221085653
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C NCOA6

1.82e-041450212482968
Pubmed

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.

TFDP3 TRIM24

1.82e-041450211331592
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

TRIM33 USP9X

1.82e-041450227626314
InteractionSP7 interactions

TET2 TRIM33 KMT2C NCOA6 IGF2BP1 ARNT CHD7 POGZ TRIM24 MGA

3.17e-093045010int:SP7
InteractionEGR2 interactions

TET2 TRIM33 KMT2C NCOA6 CHD7 POGZ TRIM24 MGA

9.04e-09171508int:EGR2
InteractionASF1A interactions

SOX6 TRIM33 NCOA6 ARNT NELFA CHD7 POGZ TRIM24 MGA

9.36e-09249509int:ASF1A
InteractionCRX interactions

MED15 TET2 TRIM33 KMT2C ARNT CHD7 POGZ TRIM24 MGA

1.11e-08254509int:CRX
InteractionXRCC6 interactions

GTF2A1 NCOA6 EXOSC10 IGF2BP1 ARNT TOX4 FN1 TINF2 DYRK1A CHD7 RUNX1 DYSF TRIM24 MGA

3.48e-089285014int:XRCC6
InteractionERG interactions

SOX6 TET2 TRIM33 KMT2C NCOA6 USP9X CHD7 TRIM24

7.14e-08223508int:ERG
InteractionAR interactions

MED15 TET2 TRIM33 KMT2C NCOA6 EXOSC10 ARNT FN1 NELFA MED12L CHD7 RUNX1 TRIM24 MGA

7.97e-089925014int:AR
InteractionDUXB interactions

TRIM33 CHD7 POGZ TRIM24

1.00e-0718504int:DUXB
InteractionCEBPA interactions

MED15 TET2 TRIM33 KMT2C NCOA6 EXOSC10 IGF2BP1 ARNT NELFA SRM CC2D1A CHD7 POGZ RUNX1 TRIM24

1.94e-0712455015int:CEBPA
InteractionNANOG interactions

TRIM33 KMT2C EXOSC10 IGF2BP1 ARNT USP9X CHD7 POGZ TRIM24 MGA

2.39e-074815010int:NANOG
InteractionYAP1 interactions

MED15 KMT2C NCOA6 EXOSC10 ARNT TOX4 USP9X CC2D1A WWTR1 POGZ RUNX1 MGA NFAT5 DCP1A

2.68e-0710955014int:YAP1
InteractionHNF4A interactions

TRIM33 KMT2C NCOA6 ARNT CHD7 POGZ TRIM24 MGA

3.55e-07275508int:HNF4A
InteractionHNF1B interactions

SOX6 TET2 KMT2C CHD7 POGZ TRIM24 MGA

4.20e-07190507int:HNF1B
InteractionFEV interactions

KMT2C NCOA6 ARNT CHD7 POGZ TRIM24 MGA

6.57e-07203507int:FEV
InteractionCNOT3 interactions

MED15 TOB2 DYRK1A R3HDM2 RUNX1 TRIM24 DCP1A

7.49e-07207507int:CNOT3
InteractionCNOT1 interactions

GTF2A1 TOB2 FN1 DYRK1A R3HDM2 WWTR1 TRIM24 DCP1A

7.76e-07305508int:CNOT1
InteractionFOS interactions

TRIM33 KMT2C NCOA6 ARNT RUNX1 TRIM24 MGA NFAT5

9.21e-07312508int:FOS
InteractionSOX2 interactions

SOX6 TET2 TRIM33 KMT2C NCOA6 EXOSC10 IGF2BP1 ARNT FN1 USP9X CHD7 POGZ SLFN5 RUNX1 TRIM24

1.06e-0614225015int:SOX2
InteractionSOX7 interactions

TET2 TRIM33 KMT2C CHD7 TRIM24

1.81e-0682505int:SOX7
InteractionLHX4 interactions

TRIM33 KMT2C CHD7 POGZ TRIM24 MGA

3.36e-06166506int:LHX4
InteractionSOX17 interactions

TRIM33 KMT2C NCOA6 CHD7 TRIM24

3.75e-0695505int:SOX17
InteractionTUT4 interactions

IGF2BP1 OTUD4 R3HDM2 TRIM24 DCP1A

3.75e-0695505int:TUT4
InteractionSMAD2 interactions

MED15 TRIM33 KMT2C NCOA6 USP9X DYRK1A WWTR1 RUNX1

4.39e-06385508int:SMAD2
InteractionCIC interactions

SOX6 ARNT LMX1B DYRK1A OTUD4 CHD7 POGZ RUNX1 MGA NFAT5

4.95e-066735010int:CIC
InteractionLHX1 interactions

KMT2C CHD7 POGZ TRIM24 MGA

5.58e-06103505int:LHX1
InteractionPABPC1 interactions

TET2 TRIM33 KMT2C TOB2 IGF2BP1 FN1 OTUD4 R3HDM2 RUNX1 DCP1A

6.91e-066995010int:PABPC1
InteractionTERF2IP interactions

TRIM33 NCOA6 ARNT TINF2 NELFA CHD7 POGZ TRIM24 MGA

7.49e-06552509int:TERF2IP
InteractionKLF5 interactions

TET2 KMT2C NCOA6 WWTR1 TRIM24 MGA

8.47e-06195506int:KLF5
InteractionNUP35 interactions

MED15 TRIM33 KMT2C NCOA6 ARNT DYRK1A WWTR1 TRIM24

8.90e-06424508int:NUP35
InteractionELF4 interactions

TRIM33 POGZ RUNX1 TRIM24 MGA

9.57e-06115505int:ELF4
InteractionTBXT interactions

KMT2C NCOA6 CHD7 POGZ TRIM24

9.98e-06116505int:TBXT
InteractionSMG7 interactions

NCOA6 ARNT OTUD4 R3HDM2 WWTR1 TRIM24 DCP1A

1.30e-05319507int:SMG7
InteractionCREBBP interactions

TRIM33 NCOA6 ARNT DYRK1A WWTR1 TACC2 RUNX1 TRIM24 MGA

1.44e-05599509int:CREBBP
InteractionAGO2 interactions

NCOA6 IGF2BP1 NELFA OTUD4 R3HDM2 WWTR1 TRIM24 DCP1A

1.93e-05472508int:AGO2
InteractionFERMT3 interactions

EXOSC10 FN1 TINF2 RUNX1

2.43e-0568504int:FERMT3
InteractionNCOA2 interactions

SOX6 NCOA6 ARNT CC2D1A WWTR1

2.57e-05141505int:NCOA2
InteractionNCOA6 interactions

MED15 KMT2C GTF2A1 NCOA6 WWTR1

2.94e-05145505int:NCOA6
InteractionSMAD1 interactions

MED15 TET2 NCOA6 USP9X RUNX1 MGA

2.95e-05243506int:SMAD1
InteractionEYA4 interactions

MED15 TET2 GTF2A1 ARNT SOBP R3HDM2

2.95e-05243506int:EYA4
InteractionNCOR1 interactions

SOX6 TRIM33 IGF2BP1 ARNT WWTR1 RUNX1 MGA

2.98e-05363507int:NCOR1
InteractionCPEB1 interactions

IGF2BP1 OTUD4 CC2D1A R3HDM2 DCP1A

3.04e-05146505int:CPEB1
InteractionELF5 interactions

TRIM33 KMT2C IGF2BP1 CHD7 TRIM24

3.14e-05147505int:ELF5
InteractionXRN1 interactions

EXOSC10 DYRK1A OTUD4 R3HDM2 WWTR1 DCP1A

4.12e-05258506int:XRN1
InteractionSOX6 interactions

SOX6 IGF2BP1 ARNT SOBP CHD7

4.30e-05157505int:SOX6
InteractionASH2L interactions

KMT2C NCOA6 WWTR1 CHD7 RUNX1 MGA

4.78e-05265506int:ASH2L
InteractionSOX5 interactions

SOX6 IGF2BP1 CHD7 POGZ TRIM24

4.99e-05162505int:SOX5
InteractionLSM12 interactions

IGF2BP1 FN1 OTUD4 R3HDM2 DCP1A

5.29e-05164505int:LSM12
InteractionPAX2 interactions

KMT2C CHD7 POGZ MGA

5.85e-0585504int:PAX2
InteractionPHC1 interactions

TET2 FN1 RUNX1 MGA

6.13e-0586504int:PHC1
InteractionTNRC6A interactions

KMT2C NCOA6 OTUD4 R3HDM2 TRIM24 DCP1A

6.49e-05280506int:TNRC6A
InteractionTEAD1 interactions

KMT2C ARNT WWTR1 CHD7 MGA

7.40e-05176505int:TEAD1
InteractionSLX4 interactions

TRIM33 EXOSC10 TOX4 NELFA DYRK1A POGZ TRIM24 MGA

7.53e-05572508int:SLX4
InteractionWWTR1 interactions

NCOA6 EXOSC10 ARNT TOX4 WWTR1 POGZ RUNX1

7.71e-05422507int:WWTR1
InteractionKLF15 interactions

MED15 KMT2C IGF2BP1 POGZ TRIM24 MGA

7.87e-05290506int:KLF15
InteractionTLX3 interactions

TET2 KMT2C NCOA6 CHD7 POGZ TRIM24

8.02e-05291506int:TLX3
InteractionPML interactions

MED15 TET2 TRIM33 ARNT NELFA TACC2 SLFN5 RUNX1 TRIM24 DCP1A

8.18e-059335010int:PML
InteractionHCFC1 interactions

MED15 KMT2C NCOA6 WWTR1 RUNX1 MGA

8.33e-05293506int:HCFC1
InteractionZFP36 interactions

IGF2BP1 DYRK1A OTUD4 R3HDM2 DCP1A

8.44e-05181505int:ZFP36
InteractionPOU5F1 interactions

TRIM33 EXOSC10 TOX4 USP9X CHD7 TRIM24 MGA RFX2

8.70e-05584508int:POU5F1
InteractionLHX2 interactions

KMT2C CHD7 POGZ TRIM24 MGA

8.89e-05183505int:LHX2
InteractionLHX3 interactions

KMT2C CHD7 POGZ TRIM24 MGA

9.36e-05185505int:LHX3
InteractionLATS1 interactions

TET2 IGF2BP1 USP9X OTUD4 WWTR1 MGA DCP1A

1.00e-04440507int:LATS1
InteractionSMAD3 interactions

MED15 TRIM33 NCOA6 USP9X DYRK1A RUNX1 TRIM24

1.10e-04447507int:SMAD3
InteractionMYOD1 interactions

TRIM33 KMT2C RUNX1 TRIM24 MGA

1.17e-04194505int:MYOD1
InteractionPEX5 interactions

TRIM33 TINF2 USP9X CAPRIN2 TRIM24

1.20e-04195505int:PEX5
InteractionKMT2A interactions

MED15 KMT2C NCOA6 WWTR1 RUNX1 DNAH8

1.22e-04314506int:KMT2A
InteractionGATA2 interactions

KMT2C NCOA6 CHD7 RUNX1 TRIM24

1.32e-04199505int:GATA2
InteractionZEB1 interactions

GTF2A1 IGF2BP1 ARNT WWTR1 MGA

1.35e-04200505int:ZEB1
InteractionLSM8 interactions

EXOSC10 ARNT MGA DCP1A

1.43e-04107504int:LSM8
InteractionTAF7 interactions

GTF2A1 WWTR1 TRIM24 MGA

1.49e-04108504int:TAF7
InteractionMED1 interactions

MED15 TET2 NCOA6 MED12L RUNX1

1.55e-04206505int:MED1
InteractionSEC24C interactions

MED15 IGF2BP1 FN1 USP9X DYRK1A

1.59e-04207505int:SEC24C
InteractionNFIC interactions

SOX6 TET2 POGZ TRIM24 MGA

1.70e-04210505int:NFIC
InteractionDDX3X interactions

TET2 TRIM33 IGF2BP1 FN1 USP9X OTUD4 LRRC7 RUNX1

1.84e-04651508int:DDX3X
InteractionMEX3B interactions

IGF2BP1 OTUD4 CC2D1A R3HDM2 DCP1A

2.19e-04222505int:MEX3B
InteractionCLTA interactions

TET2 IGF2BP1 FN1 DYRK1A CC2D1A DCP1A

2.23e-04351506int:CLTA
InteractionIGF2BP1 interactions

SOX6 IGF2BP1 FN1 OTUD4 R3HDM2 RUNX1 TRIM24

2.42e-04508507int:IGF2BP1
InteractionNFIX interactions

SOX6 KMT2C POGZ TRIM24 MGA

2.43e-04227505int:NFIX
InteractionELF1 interactions

POGZ RUNX1 TRIM24 MGA

2.69e-04126504int:ELF1
InteractionVDR interactions

NCOA6 OTUD4 RUNX1 TRIM24

2.77e-04127504int:VDR
InteractionLPP interactions

TINF2 DYRK1A WWTR1 DCP1A

2.77e-04127504int:LPP
InteractionPAX6 interactions

KMT2C NCOA6 CHD7 POGZ TRIM24 MGA

2.79e-04366506int:PAX6
InteractionFLNC interactions

FN1 DYRK1A SRM OTUD4 DYSF

2.80e-04234505int:FLNC
InteractionRSPH1 interactions

TRIM33 FN1 USP9X POGZ

3.12e-04131504int:RSPH1
InteractionTLE3 interactions

SOX6 MED15 TET2 ARNT OTUD4 RUNX1

3.22e-04376506int:TLE3
InteractionWBP2NL interactions

OTUD4 MGA

3.27e-0411502int:WBP2NL
InteractionH3C1 interactions

TRIM33 KMT2C EXOSC10 DYRK1A CHD7 POGZ TRIM24 MGA DNAH8

3.29e-04901509int:H3C1
InteractionCDC16 interactions

TRIM33 WWTR1 RUNX1 TRIM24 MGA

3.52e-04246505int:CDC16
InteractionPRRC2A interactions

SOX6 IGF2BP1 OTUD4 R3HDM2 WWTR1 RUNX1

3.86e-04389506int:PRRC2A
InteractionSOBP interactions

SOX6 SOBP

3.92e-0412502int:SOBP
InteractionLHX6 interactions

TRIM33 LMX1B OTUD4

4.03e-0458503int:LHX6
InteractionCREB1 interactions

GTF2A1 ARNT TOX4 DYRK1A POGZ

4.08e-04254505int:CREB1
InteractionPRMT1 interactions

TET2 EXOSC10 IGF2BP1 FN1 USP9X OTUD4 RUNX1 MGA DCP1A

4.12e-04929509int:PRMT1
InteractionRB1 interactions

NCOA6 ARNT DYRK1A TFDP3 WWTR1 MGA

4.13e-04394506int:RB1
InteractionPCMT1 interactions

TET2 NCOA6 FN1 DYRK1A WWTR1

4.23e-04256505int:PCMT1
InteractionHELZ interactions

IGF2BP1 OTUD4 R3HDM2 TRIM24 DCP1A

4.30e-04257505int:HELZ
InteractionASCL2 interactions

KMT2C NCOA6

4.62e-0413502int:ASCL2
InteractionC10orf71 interactions

DYRK1A TRIM24

4.62e-0413502int:C10orf71
InteractionRNF31 interactions

TET2 TRIM33 IGF2BP1 OTUD4 MGA DNAH8

4.65e-04403506int:RNF31
InteractionALKBH3 interactions

USP9X OTUD4 MGA

4.67e-0461503int:ALKBH3
GeneFamilyPHD finger proteins

TRIM33 KMT2C TRIM24

5.84e-049033388
GeneFamilyCyclins|Mediator complex

MED15 MED12L

1.65e-03333321061
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM33 TRIM24

1.30e-029533259
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

TET2 TRIM33 KMT2C USP9X MED12L CHD7 NFAT5

4.99e-08180507M8239
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

GTF2A1 SOBP USP9X CAPRIN2 WWTR1 CHD7 RUNX1 TRIM24 NFAT5

6.74e-05803489gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500

USP9X MED12L OTUD4 NFAT5 DCP1A

8.90e-05201485gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlasdev gonad_e11.5_M_SupCellPrec_Sry_top-relative-expression-ranked_1000

SOX6 TRIM33 GTF2A1 SOBP USP9X WWTR1 CHD7 RUNX1 TRIM24

9.26e-05837489gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_1000
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_1000

USP9X MED12L OTUD4 NFAT5 DCP1A

9.32e-05203485gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#3_top-relative-expression-ranked_500

USP9X OTUD4 NFAT5 DCP1A

1.37e-04116484gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500_k3
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

SOX6 IGF2BP1 SOBP R3HDM2 NFAT5

2.08e-06186505de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

SOX6 IGF2BP1 SOBP R3HDM2 NFAT5

2.08e-061865050b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellInfluenza_Severe-B_intermediate|Influenza_Severe / Disease group and Cell class

MED12L CHD7 ODC1 DNAH8

4.33e-051745044276bdaac53aebd3084323a90ecde572d3177446
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TET2 MED12L CHD7 RUNX1

4.43e-051755041ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TET2 TOX4 USP9X RFX2

5.16e-05182504dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FN1 SOBP TACC2 RUNX1

5.16e-05182504ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

KMT2C USP9X SLFN5 NFAT5

5.27e-051835048f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellsaliva-Severe-critical_progression_d28-40|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

TET2 NCOA6 TOX4 DYSF

5.61e-051865040095560ca776b01aa473ad4d6015ed78fc93ff51
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2C USP9X DYRK1A NFAT5

5.85e-05188504ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCelldroplet-Limb_Muscle-nan-3m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYRK1A CC2D1A POGZ DCP1A

5.97e-0518950416a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

SOX6 IGF2BP1 SOBP TRIM24

6.48e-05193504503a979328c68b096680b71359a26f02fafdff35
ToppCellPCW_07-8.5|World / Celltypes from embryonic and fetal-stage human lung

SOX6 IGF2BP1 TACC2 CHD7

6.61e-051945045759c83308df017f1faae248e9b85388e25254f0
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TET2 USP9X ODC1 RUNX1

7.01e-051975045bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B-B_intermediate|Influenza_Severe / Disease, condition lineage and cell class

MED12L CHD7 ODC1 DNAH8

7.15e-05198504ab622fee61714471af3a7be0af356e8a484dcaff
ToppCellmild-B_memory|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SOBP CHD7 ODC1 DNAH8

7.29e-05199504025bb65629d9e20c374e8f1ba08c36d1bb569190
Druggeldanamycin

TET2 GTF2A1 TOB2 FN1 RTTN OTUD4 SLFN5 NFAT5

1.16e-06371498ctd:C001277
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

TRIM33 DYRK1A TACC2 CHD7 TRIM24 MGA

2.53e-061824963887_DN
DrugPentetic acid [67-43-6]; Down 200; 10.2uM; HL60; HT_HG-U133A

MED15 GTF2A1 FN1 TFDP3 WWTR1 RUNX1

3.87e-061964963049_DN
Drugx ap

NCOA6 SRM ODC1

5.14e-0616493CID000065020
DrugMGBB

SRM ODC1

2.71e-054492CID009576807
DrugZK 119010

FN1 ODC1

2.71e-054492CID000130936
DrugN-cyclohexyl-1,3-propanediamine

SRM ODC1

2.71e-054492CID000018718
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

TRIM33 DYRK1A TACC2 TRIM24 MGA

3.29e-051714957535_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

TRIM33 DYRK1A TACC2 RUNX1 TRIM24

4.20e-051804954541_DN
DrugAC1NBNXJ

SRM ODC1

4.52e-055492CID004470983
Drug2,2-difluoroputrescine

SRM ODC1

4.52e-055492CID000124237
Drugpioglitazone HCl; Up 200; 10uM; PC3; HT_HG-U133A

GTF2A1 TOB2 FN1 SOBP RUNX1

4.79e-051854957528_UP
DrugGW8510; Down 200; 10uM; MCF7; HT_HG-U133A

TRIM33 TOB2 TACC2 POGZ MGA

5.04e-051874957080_DN
Drugnorspermine

DYRK1A SRM ODC1

5.35e-0534493CID000078350
DrugDihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; PC3; HT_HG-U133A

MED15 NOD1 CC2D1A RUNX1 NFAT5

5.71e-051924952081_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

MED15 TRIM33 TINF2 SOBP NFAT5

6.00e-051944951060_UP
DrugH-89, Dihydrochloride; Up 200; 0.5uM; MCF7; HT_HG-U133A

GTF2A1 ARNT NOD1 DYSF NFAT5

6.00e-051944956878_UP
DrugIndomethacin [53-86-1]; Down 200; 11.2uM; PC3; HT_HG-U133A

ARNT TOX4 NOD1 OTUD4 POGZ

6.00e-051944955049_DN
DrugBretylium tosylate [61-75-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

MED15 TRIM33 NOD1 POGZ DYSF

6.30e-051964955020_DN
Drugprobucol; Up 200; 10uM; MCF7; HG-U133A

NOD1 CC2D1A RUNX1 MGA DCP1A

6.30e-05196495592_UP
Drugprednisolone; Down 200; 1uM; MCF7; HG-U133A

TRIM33 GTF2A1 DYRK1A POGZ RUNX1

6.30e-05196495265_DN
DrugEquilin [474-86-2]; Down 200; 15uM; HL60; HT_HG-U133A

TRIM33 ARNT FN1 WWTR1 DYSF

6.45e-051974953039_DN
Drug(+/-)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A

TOB2 FN1 TINF2 WWTR1 TRIM24

6.45e-05197495161_DN
DrugMethoxamine hydrochloride [61-16-5]; Up 200; 16.2uM; HL60; HT_HG-U133A

TOB2 TFDP3 RUNX1 NFAT5 RFX2

6.45e-051974952488_UP
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

ARNT TINF2 CAPRIN2 OTUD4 NFAT5

6.61e-051984957003_DN
DrugCefotiam hydrochloride; Down 200; 7.2uM; HL60; HT_HG-U133A

ARNT CC2D1A WWTR1 RUNX1 NFAT5

6.61e-051984952458_DN
DrugProbenecid [57-66-9]; Down 200; 14uM; PC3; HT_HG-U133A

GTF2A1 ARNT TINF2 CC2D1A RUNX1

6.61e-051984954185_DN
Drug0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A

GTF2A1 FN1 WWTR1 NFAT5 RFX2

6.77e-051994954334_UP
Drugn-butyl-1,3-diaminopropane

SRM ODC1

6.77e-056492CID000095733
Drugethyl stearate

SRM ODC1

6.77e-056492CID000008122
DrugM2 t

SRM ODC1

6.77e-056492CID000167321
DrugPindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT_HG-U133A

TINF2 WWTR1 POGZ RUNX1 NFAT5

6.93e-052004952075_DN
Drugalpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A

AMELY FN1 RUNX1 DYSF RFX2

6.93e-052004955570_UP
Drugsaran

DYRK1A RUNX1 NFAT5

7.49e-0538493CID000062706
Drugmg BC

SRM ODC1

9.46e-057492CID009589355
DrugMGBCP

SRM ODC1

1.26e-048492CID009576877
DrugN-carbamoylputrescine

SRM ODC1

1.26e-048492CID000000502
DrugCP-65

FN1 ODC1

1.26e-048492CID000452628
DrugAdoDATO

SRM ODC1

1.62e-049492CID000100766
Drug5'-methylthiotubercidin

SRM ODC1

1.62e-049492CID000188350
DrugNSC401575

NELFA ODC1 RUNX1 NFAT5

1.71e-04129494CID000003165
DiseaseNeurodevelopmental Disorders

KMT2C LMX1B DYRK1A POGZ

1.76e-0593494C1535926
Diseasevital capacity

SOX6 TET2 NCOA6 FN1 LMX1B CAPRIN2 OTUD4 CHD7 TRIM24 NFAT5

2.97e-0512364910EFO_0004312
Diseasemean reticulocyte volume

SOX6 TRIM33 TOB2 NOD1 RTTN DYRK1A OTUD4 RUNX1

4.71e-05799498EFO_0010701
Diseaseserum albumin measurement

SOX6 EXOSC10 ARNT SNX8 R3HDM2 RUNX1 DYSF

5.22e-05592497EFO_0004535
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

TET2 KMT2C RUNX1

5.81e-0545493DOID:3748 (is_implicated_in)
Diseasedisorder of pharynx

TET2 ARNT DYSF

6.21e-0546493MONDO_0020592
Diseasetea consumption measurement

SOX6 TOB2 ARNT NFAT5

6.34e-05129494EFO_0010091
DiseaseC-reactive protein measurement

SOX6 NCOA6 TOB2 IGF2BP1 LMX1B DYRK1A R3HDM2 CHD7 NFAT5

1.45e-041206499EFO_0004458
DiseaseColorectal Carcinoma

TET2 KMT2C ARNT FN1 SNX8 ODC1 DNAH8

1.51e-04702497C0009402
DiseasePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma

RUNX1 MGA

1.76e-0412492C0023485
Diseasemean platelet volume

TET2 TOX4 RTTN SNX8 DYRK1A CHD7 RUNX1 RFX2

2.54e-041020498EFO_0004584
Diseasecoronary artery disease

SOX6 TET2 NCOA6 IGF2BP1 FN1 R3HDM2 LRRC7 NFAT5

7.23e-041194498EFO_0001645
Diseaseairway responsiveness measurement

SOBP CAPRIN2

7.28e-0424492EFO_0006897
DiseaseGlioblastoma Multiforme

TRIM33 FN1 RUNX1

8.42e-04111493C1621958
Diseasemyeloid white cell count

TET2 GTF2A1 FN1 MED12L DYRK1A R3HDM2 CHD7

8.55e-04937497EFO_0007988
DiseaseIntellectual Disability

KMT2C RTTN MED12L POGZ ODC1

8.60e-04447495C3714756
DiseaseFEV/FEC ratio

MED15 TET2 TRIM33 LMX1B OTUD4 R3HDM2 WWTR1 MGA

8.68e-041228498EFO_0004713
DiseaseSezary Syndrome

TET2 KMT2C

9.23e-0427492C0036920
DiseaseHematopoetic Myelodysplasia

TET2 RUNX1

1.07e-0329492C2713368
Diseaseintellectual disability (is_implicated_in)

DYRK1A CC2D1A

1.14e-0330492DOID:1059 (is_implicated_in)
Diseasepuberty onset measurement

SOX6 NCOA6 NFAT5

1.19e-03125493EFO_0005677
Diseasemacrophage inflammatory protein 1a measurement

RTTN CAPRIN2

1.30e-0332492EFO_0008218
DiseaseFocal glomerulosclerosis

FN1 LMX1B

1.64e-0336492C0017668

Protein segments in the cluster

PeptideGeneStartEntry
PRQQQQQTELDMVPG

ARNT

501

P27540
QQPRVRQQALMPVPG

AMELY

106

Q99218
QIQQPLTNQVMPDIV

DYRK1A

61

Q13627
QSMQQNQDPEVFVQP

DCP1A

461

Q9NPI6
ENPVNPMGQQMPIDQ

CHD7

31

Q9P2D1
SDSQNVVQPPFQQPM

R3HDM2

616

Q9Y2K5
PFQGFIENPVMRQNI

OTUD4

866

Q01804
ALQPQPEQQPFSQML

KIAA0895L

56

Q68EN5
PVLMPNQDPFLQAAQ

KMT2C

2241

Q8NEZ4
QPTFPMVPQQLQHQQ

KMT2C

3301

Q8NEZ4
QDPMRPRQPQVRQQQ

MED12L

2046

Q86YW9
GLQAMQPQQPLFPRQ

MED12L

2091

Q86YW9
PVAMVAPQTQAPAQQ

NELFA

411

Q9H3P2
NTQPNLQPVMFRNPG

MGA

1821

Q8IWI9
DQQIQDMPVPQNDPQ

LRRC7

511

Q96NW7
QAPEQEMVQVFIPAQ

IGF2BP1

401

Q9NZI8
MVPNIPPQEASNRLQ

DNAH8

1221

Q96JB1
PMVVQQPPVQPQVQQ

MED15

351

Q96RN5
PRVQVESFNQVQAMP

NOD1

636

Q9Y239
QMDPVAQPQVNPTLQ

GPR152

351

Q8TDT2
IQTPMLSQEQAQPPQ

NFAT5

1191

O94916
RNPMVQQGNVPPNFM

NCOA6

476

Q14686
NPVPPLVRQQINEMH

EXOSC10

556

Q01780
RQAQQMVQPQSPVAV

FN1

31

P02751
PVPPEVAQQYQDIMQ

CC2D1A

871

Q6P1N0
DNPPVQQIVQLSPVM

GOLGA6C

676

A6NDK9
QAMQTVFNVNAPLPP

CAPRIN2

761

Q6IMN6
PPQREANIYMVPQNI

DYSF

1311

O75923
LMQQFQNPDFPPEVE

ODC1

416

P11926
PQSQMQDTRQIQPSP

RUNX1

236

Q01196
PQDKSNFQQMEVPPR

RTTN

146

Q86VV8
NFQQMEVPPRPVVNQ

RTTN

151

Q86VV8
DPNLSQPIMPIQQNV

USP9X

2261

Q93008
QAAPQMLQQQPPRLI

TRIM33

556

Q9UPN9
PQAIVQQVPAPSRMQ

SNX8

41

Q9Y5X2
MQPISLPRVQQVPQQ

RFX2

46

P48378
PVRNVRPVQNAMNQV

POGZ

156

Q7Z3K3
MRQFFTVGQQPQIPI

SOX6

721

P35712
SVVLQQQVIPQMQPG

GTF2A1

181

P52655
QPQMPKQNPVVEQNS

TRIM24

431

O15164
PIFMEQQIMQQIRPP

SOBP

396

A7XYQ1
QQIMQQIRPPFIRGP

SOBP

401

A7XYQ1
LAEPMEQNPPQQQRL

TINF2

211

Q9BSI4
QEGRQQPVPAPQQKM

TACC2

1086

O95359
EPVQPLTQQQVAQMQ

SRM

261

P19623
VNIDQQVVIGMPQRP

TFDP3

51

Q5H9I0
QQGRFVPPDMMQPQQ

YIPF5

46

Q969M3
MRNMIPQDNENPPQQ

ZNF788P

1

Q6ZQV5
RLSGPVMQQSQQPQP

TET2

1516

Q6N021
QQPPQQPRMARSPTN

TOB2

211

Q14106
MNPAPQLQDEIQPQL

UBQLN3

491

Q9H347
YLQQVMQEARQNPPP

SLFN5

721

Q08AF3
MPQPPTQQQVTILQQ

TOX4

451

O94842
TPMNINPQQTRFPDF

WWTR1

346

Q9GZV5
PLAPPQQQIVAMEQS

LMX1B

311

O60663