Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglucan 1,4-alpha-glucosidase activity

MGAM MGAM2

1.67e-052822GO:0004339
GeneOntologyMolecularFunctionalpha-1,4-glucosidase activity

MGAM MGAM2

1.65e-045822GO:0004558
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R9 TAS2R41 TAS2R60

1.82e-0427823GO:0033038
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R9 TAS2R41 TAS2R60

3.33e-0433823GO:0008527
GeneOntologyMolecularFunctionalpha-glucosidase activity

MGAM MGAM2

3.45e-047822GO:0090599
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

RELN LRP1 LRP2

5.48e-0439823GO:0070325
GeneOntologyCellularComponentGABA-ergic synapse

GABRB1 GABRB3 DRD1 ATR CACNA2D2 ITPR1

4.55e-05164826GO:0098982
GeneOntologyCellularComponentpresynaptic active zone

GABRB1 CACNA2D2 ARFGAP3 CNTNAP1 NUFIP1

2.34e-04141825GO:0048786
MousePhenoimpaired coordination

GABRB3 RELN DRD1 ACER3 RNF103 CACNA2D2 SCN4A CNTNAP1 LRP2 FAF1 ITPR1

5.01e-064786011MP:0001405
MousePhenomuscle twitch

RELN CACNA2D2 SCN4A CNTNAP1 ITPR1

7.72e-0664605MP:0009046
MousePhenolethality at weaning, complete penetrance

GABRB3 RELN CNTNAP1 ITPR1

4.37e-0546604MP:0011083
MousePhenomuscle spasm

RELN CACNA2D2 CNTNAP1 ITPR1

1.25e-0460604MP:0000743
DomainArfGap

ARFGAP2 ACAP1 ARFGAP3 ACAP2

7.18e-0629814SM00105
DomainArfGap

ARFGAP2 ACAP1 ARFGAP3 ACAP2

7.18e-0629814PF01412
DomainARFGAP

ARFGAP2 ACAP1 ARFGAP3 ACAP2

7.18e-0629814PS50115
DomainArfGAP

ARFGAP2 ACAP1 ARFGAP3 ACAP2

7.18e-0629814IPR001164
DomainGPCR_2_brain_angio_inhib

ADGRB1 ADGRB2

5.56e-053812IPR008077
DomainGABAAb_rcpt

GABRB1 GABRB3

5.56e-053812IPR002289
DomainFA58C

CPXM2 CNTNAP1 CPXM1

9.88e-0521813SM00231
DomainFA58C_3

CPXM2 CNTNAP1 CPXM1

9.88e-0521813PS50022
DomainFA58C_1

CPXM2 CNTNAP1 CPXM1

9.88e-0521813PS01285
DomainFA58C_2

CPXM2 CNTNAP1 CPXM1

9.88e-0521813PS01286
DomainNtCtMGAM_N

MGAM MGAM2

1.11e-044812PF16863
DomainGal_mutarotase_N

MGAM MGAM2

1.11e-044812IPR031727
DomainF5_F8_type_C

CPXM2 CNTNAP1 CPXM1

1.49e-0424813PF00754
DomainFA58C

CPXM2 CNTNAP1 CPXM1

1.49e-0424813IPR000421
DomainTAS2R

TAS2R9 TAS2R41 TAS2R60

1.90e-0426813PF05296
DomainT2R

TAS2R9 TAS2R41 TAS2R60

1.90e-0426813IPR007960
DomainGlyco_hydro_31_AS

MGAM MGAM2

2.76e-046812IPR030458
DomainGlyco_hydro_31

MGAM MGAM2

3.85e-047812IPR000322
DomainGlyco_hydro_31

MGAM MGAM2

3.85e-047812PF01055
DomainGLYCOSYL_HYDROL_F31_1

MGAM MGAM2

3.85e-047812PS00129
DomainTrefoil

MGAM MGAM2

5.11e-048812PF00088
DomainP_TREFOIL_2

MGAM MGAM2

6.56e-049812PS51448
DomainPD

MGAM MGAM2

6.56e-049812SM00018
DomainGalactose-bd-like

NTN4 CPXM2 CNTNAP1 CPXM1

7.44e-0494814IPR008979
Domain-

MGAM MGAM2

9.96e-04118124.10.110.10
DomainGAIN_dom_N

ADGRB1 ADGRB2

9.96e-0411812IPR032471
DomainMethyltransf_16

METTL23 METTL22

9.96e-0411812IPR019410
DomainMethyltransf_16

METTL23 METTL22

9.96e-0411812PF10294
DomainGAIN

ADGRB1 ADGRB2

9.96e-0411812PF16489
DomainP_trefoil_dom

MGAM MGAM2

1.19e-0312812IPR000519
DomainCarboxyPept_regulatory_dom

CPXM2 CPXM1

1.40e-0313812IPR014766
Domain-

CPXM2 CPXM1

1.40e-03138122.60.40.1120
Domain-

MRC1 MRC2

1.40e-03138122.10.10.10
DomainFN_type2_col-bd

MRC1 MRC2

1.63e-0314812IPR000562
DomainFN2_2

MRC1 MRC2

1.63e-0314812PS51092
DomainLdl_recept_b

LRP1 LRP2

1.63e-0314812PF00058
DomainLDLRB

LRP1 LRP2

1.63e-0314812PS51120
Domainfn2

MRC1 MRC2

1.63e-0314812PF00040
DomainFN2_1

MRC1 MRC2

1.63e-0314812PS00023
DomainFN2

MRC1 MRC2

1.63e-0314812SM00059
DomainLY

LRP1 LRP2

1.88e-0315812SM00135
DomainLDLR_classB_rpt

LRP1 LRP2

1.88e-0315812IPR000033
DomainGal_mutarotase_SF_dom

MGAM MGAM2

2.42e-0317812IPR011013
DomainHEAT_type_2

PIK3R4 ATR

2.42e-0317812IPR021133
DomainCarboxyPept-like_regulatory

CPXM2 CPXM1

2.42e-0317812IPR008969
DomainZn_pept

CPXM2 CPXM1

2.72e-0318812SM00631
DomainBAR

ACAP1 ACAP2

3.03e-0319812PS51021
DomainCARBOXYPEPT_ZN_2

CPXM2 CPXM1

3.03e-0319812PS00133
DomainCARBOXYPEPT_ZN_1

CPXM2 CPXM1

3.36e-0320812PS00132
Domain-

CPXM2 CNTNAP1 CPXM1

3.93e-03738132.60.120.260
DomainPeptidase_M14

CPXM2 CPXM1

4.43e-0323812PF00246
DomainGABAA/Glycine_rcpt

GABRB1 GABRB3

4.43e-0323812IPR006028
DomainPeptidase_M14

CPXM2 CPXM1

4.43e-0323812IPR000834
DomainEGF_1

NTN4 RELN CNTNAP1 LRP1 LRP2

5.03e-03255815PS00022
DomainC_TYPE_LECTIN_1

MRC1 LAYN MRC2

5.08e-0380813PS00615
DomainRicin_B_lectin

MRC1 MRC2

5.22e-0325812PF00652
DomainHormR

ADGRB1 ADGRB2

5.22e-0325812SM00008
DomainEGF-like_CS

NTN4 RELN CNTNAP1 LRP1 LRP2

5.54e-03261815IPR013032
DomaincEGF

LRP1 LRP2

5.64e-0326812IPR026823
DomaincEGF

LRP1 LRP2

5.64e-0326812PF12662
DomainLectin_C

MRC1 LAYN MRC2

5.82e-0384813PF00059
DomainCLECT

MRC1 LAYN MRC2

5.82e-0384813SM00034
DomainC_TYPE_LECTIN_2

MRC1 LAYN MRC2

6.01e-0385813PS50041
DomainC-type_lectin-like

MRC1 LAYN MRC2

6.21e-0386813IPR001304
DomainRICIN

MRC1 MRC2

6.53e-0328812SM00458
Pubmed

GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.

GABRB1 GABRB3

5.90e-06285221735059
Pubmed

Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.

MRC1 MRC2

5.90e-06285219224860
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

5.90e-06285234445520
Pubmed

ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.

ACAP1 ACAP2

5.90e-06285211062263
Pubmed

Epileptic encephalopathy de novo GABRB mutations impair γ-aminobutyric acid type A receptor function.

GABRB1 GABRB3

5.90e-06285226950270
Pubmed

Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.

GABRB1 GABRB3

5.90e-06285218650446
Pubmed

Mannose receptor regulation of macrophage cell migration.

MRC1 MRC2

5.90e-06285217596337
Pubmed

HIV-1 Tat represses transcription from the mannose receptor promoter.

MRC1 MRC2

5.90e-06285211120831
Pubmed

Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.

MRC1 MRC2

5.90e-06285223148569
Pubmed

The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.

MRC1 MRC2

5.90e-06285217518370
Pubmed

CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor.

MRC1 MRC2

5.90e-06285215047828
Pubmed

Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation.

TAS2R41 TAS2R60

5.90e-06285233559206
Pubmed

Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.

MRC1 MRC2

5.90e-06285217360361
Pubmed

Two human ARFGAPs associated with COP-I-coated vesicles.

ARFGAP2 ARFGAP3

5.90e-06285217760859
Pubmed

HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.

MRC1 MRC2

1.77e-05385215955449
Pubmed

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

MRC1 ATR

1.77e-05385211715017
Pubmed

Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.

MRC1 MRC2

1.77e-05385230366943
Pubmed

Distribution of murine mannose receptor expression from early embryogenesis through to adulthood.

MRC1 MRC2

1.77e-0538529560474
Pubmed

Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.

ARFGAP2 ARFGAP3

1.77e-05385219015319
Pubmed

Three homologous ArfGAPs participate in coat protein I-mediated transport.

ARFGAP2 ARFGAP3

1.77e-05385219299515
Pubmed

Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

ADGRB1 ADGRB2

1.77e-0538529533023
Pubmed

Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.

ADGRB1 ADGRB2

1.77e-05385215225653
Pubmed

Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses.

GABRB1 GABRB3

1.77e-05385218281286
Pubmed

HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.

MRC1 MRC2

1.77e-05385222132194
Pubmed

GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice.

GABRB1 GABRB3

1.77e-0538527893750
Pubmed

Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.

GABRB1 GABRB3

1.77e-05385211085308
Pubmed

Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning.

DRD1 ITPR1

1.77e-05385222033896
Pubmed

GABAA receptor beta subunit mRNA expression in the human alcoholic brain.

GABRB1 GABRB3

1.77e-05385215337300
Pubmed

Differential expression of GABAA/benzodiazepine receptor beta 1, beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum.

GABRB1 GABRB3

1.77e-0538521282920
Pubmed

Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference.

DRD1 ITPR1

1.77e-05385223000618
Pubmed

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.

ACAP1 ACAP2

1.77e-05385211050434
Pubmed

Receptors for bitter and sweet taste.

TAS2R9 TAS2R41 TAS2R60

3.12e-052585312139982
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R9 TAS2R41 TAS2R60

3.52e-052685311696554
Pubmed

Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.

DRD1 LRP2

3.53e-05485216908842
Pubmed

ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.

ACAP1 ACAP2

3.53e-05485227330119
Pubmed

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

PTPRB CNTNAP1

3.53e-0548529118959
Pubmed

Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.

LRP1 LRP2

3.53e-05485212413896
Pubmed

M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.

MRC1 MRC2

3.53e-05485224019537
Pubmed

Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum.

RELN ITPR1

3.53e-0548522707487
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

LRP1 LRP2

3.53e-0548527775583
Pubmed

Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.

LRP1 LRP2

3.53e-05485211421580
Pubmed

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.

TAS2R41 TAS2R60

3.53e-05485223632330
Pubmed

Substrate specificities and activities of AZAP family Arf GAPs in vivo.

ACAP1 ACAP2

3.53e-05485218003747
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R9 TAS2R41 TAS2R60

3.95e-052785312581520
Pubmed

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

TAS2R9 TAS2R41 TAS2R60

4.42e-052885315744053
Pubmed

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.

LRP1 LRP2

5.87e-05585216101684
Pubmed

The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors.

GABRB1 GABRB3

5.87e-05585215198677
Pubmed

Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.

RELN ITPR1

5.87e-05585219167437
Pubmed

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.

LRP2 PKHD1L1

5.87e-05585220048263
Pubmed

A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.

GABRB1 GABRB3

5.87e-05585212595241
Pubmed

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.

GABRB1 GABRB3

5.87e-0558529039914
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2

5.87e-05585219047013
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

LRP1 LRP2

5.87e-05585218685438
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R9 TAS2R41 TAS2R60

7.98e-053485315496549
Pubmed

Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous.

GABRB3 RELN

8.80e-05685210407039
Pubmed

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

LRP1 LRP2

8.80e-0568529837937
Pubmed

Evolution of GABA(A) receptor diversity in the human genome.

GABRB1 GABRB3

8.80e-05685210023064
Pubmed

The GABAA Receptor β Subunit Is Required for Inhibitory Transmission.

GABRB1 GABRB3

8.80e-05685229706582
Pubmed

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.

MRC1 MRC2

8.80e-05685233543002
Pubmed

HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription.

MRC1 MRC2

8.80e-05685216615932
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GABRB1 GABRB3 ARFGAP2 TRIM28 ARFGAP3 CNTNAP1 ADGRB1 ADGRB2 PSMD1 SVOP ITPR1

1.03e-041139851136417873
Pubmed

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.

RELN ITPR1

1.23e-04785211226314
Pubmed

Arf4 is required for Mammalian development but dispensable for ciliary assembly.

LRP2 PKHD1L1

1.23e-04785224586199
Pubmed

Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.

RELN ITPR1

1.23e-0478528863127
Pubmed

Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.

GABRB1 GABRB3

1.23e-04785220843900
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

LRP1 LRP2

1.23e-04785212169628
Pubmed

HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.

MRC1 MRC2

1.23e-04785216547227
Pubmed

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

RELN LRP1

1.64e-04885210380922
Pubmed

GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.

GABRB1 GABRB3

1.64e-04885211528422
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

GABRB1 RELN KCNK1

1.86e-044585325979088
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

RELN ITPR1

2.10e-04985231491533
Pubmed

LDL receptor-related protein as a component of the midkine receptor.

LRP1 LRP2

2.10e-04985210772929
Pubmed

Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.

RELN ITPR1

2.62e-041085232161359
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PIK3R4 RELN TAF1C CNTNAP1 TRPS1 LRP1 LRP2 PSMD1 FAF1 LDB2 NUFIP1

2.93e-041285851135914814
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

RELN LRP2

3.20e-041185223968836
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP2

3.20e-041185224639464
Pubmed

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

CD1D SIGLEC1

3.20e-041185229249358
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PGAP3 SLC16A5 CHST15 TRIM28 INTS1 ADGRB2 PCNX1 TNKS1BP1 SPEN CRAMP1

3.64e-041105851035748872
Pubmed

Identification of epilepsy genes in human and mouse.

CACNA2D2 ITPR1

3.83e-041285211700294
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SLC35F3 TRIM28 TAF1C TRPS1 LRP1 LRP2 SIGLEC1 FAR1 QSOX2 NUFIP1

3.94e-041116851031753913
Pubmed

A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.

GABRB1 GABRB3 DRD1

3.94e-045885311140838
Pubmed

Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.

ADGRB2 ITPR1

4.52e-041385214697242
Pubmed

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.

ADGRB2 LRP2

4.52e-041385212508107
Pubmed

Identification and characterization of human taste receptor genes belonging to the TAS2R family.

TAS2R41 TAS2R60

4.52e-041385212584440
Pubmed

The biochemical anatomy of cortical inhibitory synapses.

GABRB1 GABRB3

5.27e-041485222768092
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

LRP1 LRP2

5.27e-041485217389516
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1 LRP2

5.27e-041485215082773
Pubmed

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

LRP1 SIGLEC1

5.27e-041485226453377
Pubmed

Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.

CPXM2 CHST15

5.27e-041485223457544
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRPS1 LRP1 LRP2 PSMD1 TNKS1BP1 FAR1

5.72e-0441885634709266
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

PTPRB LRP1 PCNX1 SPEN DNAH8 SLC45A4

5.86e-0442085628065597
Pubmed

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

CPXM2 CHST15

6.07e-041585222383091
Pubmed

Maternal immunoglobulins are distributed in the offspring's brain to support the maintenance of cortical interneurons in the postnatal period.

MRC1 RELN

6.93e-041685238750507
Pubmed

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

ATR TRIM28

6.93e-041685228123024
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

TRIM28 MRC2 TM9SF3 CNTNAP1 INTS1 LRP1 PSMD1 FAR1 PRAME QSOX2

7.04e-041203851029180619
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

DRD1 ITPR1

7.84e-041785220395553
Pubmed

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development.

MRC1 SIGLEC1

7.84e-041785232259484
Pubmed

Single-cell transcriptomic analysis of mouse neocortical development.

RELN KCNK1 BTBD17 LDB2

8.20e-0417085430635555
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRB1 GABRB3

8.80e-041885219078961
Pubmed

Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.

ATR TRIM28

8.80e-041885232994318
GeneFamilyArfGAPs

ARFGAP2 ACAP1 ARFGAP3 ACAP2

3.39e-0633574395
GeneFamilyAdhesion G protein-coupled receptors, subfamily B

ADGRB1 ADGRB2

2.92e-053572912
GeneFamilyTaste 2 receptors

TAS2R9 TAS2R41 TAS2R60

2.50e-04395731162
GeneFamilyLow density lipoprotein receptors

LRP1 LRP2

7.45e-0413572634
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ACAP1 ACAP2

1.29e-03175721291
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRB1 GABRB3

1.61e-0319572563
GeneFamilyCarboxypeptidases

CPXM2 CPXM1

1.97e-03215721321
GeneFamilyMethyltransferase like

METTL23 METTL22

4.84e-0333572963
GeneFamilyADAM metallopeptidase domain containing|CD molecules

MRC1 CD1D MRC2 LRP1 SIGLEC1

7.93e-03394575471
GeneFamilyC-type lectin domain family

MRC1 MRC2

9.64e-0347572494
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

MRC1 RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

3.05e-0816784797d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2 FAM87A

7.38e-08190847876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2 FAM87A

7.38e-08190847be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2 FAM87A

7.38e-0819084709a8855901c3c9332dbaab3e40166485b696d0f1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 SLC35F3 MRC2 TRPS1 LRP1 LDB2 ITPR1

7.65e-08191847c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 SLC35F3 MRC2 TRPS1 LRP1 LDB2 ITPR1

7.65e-08191847cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

9.78e-08198847b3a020522e064bb61949d38e442f24026e339364
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

9.78e-08198847fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-8|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

CD1D SGMS2 ACER3 EVI2A PRR11 TAS2R60

3.92e-071498460c18acfc5f0a9dd25ee5c38f97498b3278e65b42
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 SCN4A PKHD1L1

6.88e-07164846a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 SCN4A PKHD1L1

6.88e-071648461a1795969673232191425dde84ab24ee6a98143f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 SCN4A PKHD1L1

6.88e-071648468f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CPXM2 CHST15 PKHD1L1 LDB2

8.48e-071708466035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CPXM2 CHST15 PKHD1L1 LDB2

8.48e-07170846c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CPXM2 CHST15 PKHD1L1 LDB2

8.48e-07170846dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

MRC1 RELN PTPRB LAYN PKHD1L1 LDB2

1.04e-0617684698c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

MRC1 RELN PTPRB LAYN PKHD1L1 LDB2

1.04e-06176846c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

1.04e-061768465d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 PRAME LDB2

1.07e-06177846c274fbdc141855ff4581d437d4997c64cc193278
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 PRAME LDB2

1.07e-06177846f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 PRAME LDB2

1.07e-06177846c8a51e480b978dc0ded85583261f2c892e085be8
ToppCellCOVID-19-Heart-Lymph_EC|Heart / Disease (COVID-19 only), tissue and cell type

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

1.15e-06179846411620201a860716a8773b92f50f7b94ef34a586
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 PKHD1L1 LDB2

1.26e-0618284641b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 PKHD1L1 LDB2

1.26e-061828465e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB CHST15 PKHD1L1 LDB2

1.26e-06182846b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

1.39e-06185846f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCellEndoth-Lymph|World / shred by cell class for parenchyma

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

1.39e-0618584697a6c4cd00684d4085d36ef32f7dbb99563ed357
ToppCellEndothelial-endothelial_cell_of_lymph_vessel|World / Lineage, Cell type, age group and donor

RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

1.52e-0618884680910dcbb51990f2baed240f319456c0d3fa2065
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

1.52e-06188846aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RELN PTPRB CPXM2 CHST15 PKHD1L1 LDB2

1.57e-061898460d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RELN PTPRB LAYN CHST15 PKHD1L1 LDB2

1.57e-0618984655a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 SLC35F3 MRC2 LRP1 LDB2 ITPR1

1.57e-06189846c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 SLC35F3 MRC2 LRP1 LDB2 ITPR1

1.62e-061908462e592323085ba9c019d678ac2a784462ab470ed9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 SLC35F3 MRC2 LRP1 LDB2 ITPR1

1.62e-06190846445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellCOVID-19-lung-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

1.72e-06192846cbe57cda44232b183821ac633b60a2668265e616
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB3 SLC35F3 KCNK1 ADGRB2 LDB2 ITPR1

1.72e-061928465c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ACSM4 CHST15 TRPS1 LRP1 SIGLEC1

1.83e-0619484645708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN PTPRB CHST15 PKHD1L1 LDB2

2.06e-061988469ab0db78394e730f6866b2db80047149024ad5f6
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN PTPRB CHST15 PKHD1L1 LDB2

2.06e-06198846e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

2.18e-06200846b515b2ab0c3f5928dd67f2f227fc932451c272bb
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RELN LAYN CHST15 PKHD1L1 LDB2

2.18e-0620084635f6c7f2469d12748c27f2a5d4a161ef839b4a07
ToppCellCOVID-19_Mild-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

RELN PGAP3 LRP2 PCNX1 SIGLEC1

3.96e-06125845e58c208b4355252ceabe04a468dd19a1f436182c
ToppCellCOVID-19-kidney-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN LAYN CHST15 PKHD1L1 LDB2

9.01e-06148845f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 C17orf99 LRP1 SIGLEC1 PKHD1L1

1.31e-0516084556e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 C17orf99 LRP1 SIGLEC1 PKHD1L1

1.31e-05160845bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

1.35e-05161845fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

1.35e-05161845c53c461fc721a7960cef86662f49e2a495520701
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 C17orf99 LRP1 SIGLEC1 PKHD1L1

1.35e-0516184560f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

1.40e-051628452ac02523348660e514d464f8f2434ee0c312d784
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

RELN PTPRB LAYN PKHD1L1 LDB2

1.57e-05166845c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCellControl|World / group, cell type (main and fine annotations)

NTN4 SGMS2 CACNA2D2 KCNK1 LRP2

1.66e-05168845a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellEndothelial-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

RELN LAYN PKHD1L1 LDB2 FAM87A

1.81e-0517184507ff7059071da83da1d8f266a586573920d75b58
ToppCellEndothelial-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

RELN CPXM2 PKHD1L1 LDB2 FAM87A

1.86e-05172845d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 RELN CHST15 PKHD1L1 LDB2

1.92e-051738457dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

MRC1 CD1D TM9SF3 LRP1 CPXM1

2.02e-051758452eca4c168dea2017ea0e383006e28abed22f32ec
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SLC16A5 SLC35F3 ARFGAP3 CCDC116

2.02e-0517584528b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB PKHD1L1 LDB2

2.02e-051758459a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB PKHD1L1 LDB2

2.02e-0517584554c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN PTPRB PKHD1L1 LDB2

2.02e-051758452b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-plasma_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SLC16A5 SLC35F3 ARFGAP3 CCDC116

2.02e-05175845ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 RELN LAYN CHST15 LDB2

2.14e-05177845dfaed388926ce050730492a532824af68bf4feff
ToppCellCOVID-19-Heart-Lymph_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN LAYN CHST15 PKHD1L1 LDB2

2.14e-05177845326fde0734ef0d7272693966d346ca479b9d8147
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN LAYN CHST15 PKHD1L1 LDB2

2.14e-05177845b1775e05c28883a15c56628028770bc59d3233fb
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

SGMS2 MRC2 LRP1 CPXM1 EVI2A

2.57e-05184845684d05340a3dfb8aa08b881516a37f9627a10448
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

RELN PTPRB LAYN PKHD1L1 LDB2

2.64e-051858454a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRC1 RELN PTPRB CHST15 PKHD1L1

2.64e-051858453be9e05b929ac4d956b1d53284072f668a6c1959
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

RELN PTPRB LAYN PKHD1L1 LDB2

2.64e-0518584536ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRC1 RELN PTPRB CHST15 PKHD1L1

2.64e-05185845c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB3 SLC35F3 KCNK1 LDB2 ITPR1

2.71e-0518684584ba666237c18189d7e7556bd92dd953af733c00
ToppCell(4)_Lymph_vessel|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

MRC1 RELN LAYN PKHD1L1 LDB2

2.71e-051868456b3afc2ae870ff73e30a60ce84fcee0eb365d809
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|343B / Donor, Lineage, Cell class and subclass (all cells)

RELN LAYN CHST15 PKHD1L1 LDB2

2.71e-051868457a8da2ad140bea3207bd868212cc5e201d586772
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|343B / Donor, Lineage, Cell class and subclass (all cells)

RELN LAYN CHST15 PKHD1L1 LDB2

2.71e-05186845dc394034929c6b10ae0e1c1a028cc3d4ce873298
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

2.78e-0518784565d406122dffe18279f14a1ed35ba091730b97be
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

2.78e-051878454c15c0ed41a55271fc793cb76fee97fa64190369
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN CHST15 PKHD1L1 LDB2

2.78e-051878455274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

RELN PTPRB CHST15 PKHD1L1 LDB2

2.78e-051878451e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

RELN PTPRB CHST15 PKHD1L1 LDB2

2.85e-05188845c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1

2.85e-0518884526915db8863f4115b46a81982e187322e21600fd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1

2.85e-051888453f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 RELN LAYN CHST15 PKHD1L1

2.85e-0518884561ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

RELN PTPRB CHST15 PKHD1L1 LDB2

2.85e-051888452db80767903703e7e0a1a37c598f7877a909ee94
ToppCellCOVID-19-lung-Lymphatic_EC|lung / Disease (COVID-19 only), tissue and cell type

RELN LAYN CHST15 PKHD1L1 LDB2

2.93e-05189845c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCellEC-Sinusoidal_ECs|World / Lineage and Cell class

MRC1 CRYBB3 RELN PTPRB LDB2

2.93e-051898459a0956c8a7069ba3bd0fa56d052d6e514453e578
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB3 SLC35F3 KCNK1 LDB2 ITPR1

2.93e-05189845a75226616340045b581d08429d2e123e041dee55
ToppCellwk_08-11-Endothelial-Lymph_endothelial-Lymphatic_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MRC1 RELN PTPRB CHST15 PKHD1L1

3.00e-05190845279c5f68b993dc7adbf9aa69fffb1321cdebc48a
ToppCellIPF-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.00e-05190845ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCellwk_08-11-Endothelial-Lymph_endothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MRC1 RELN PTPRB CHST15 PKHD1L1

3.00e-05190845d7f1dc032d161529559e01832d1a3112c6f6cc1a
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

MRC1 ACER3 TRPS1 LRP1 SIGLEC1

3.08e-051918459c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC35F3 MRC2 LRP1 LDB2 ITPR1

3.08e-05191845806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

PTPRB CPXM2 CHST15 PKHD1L1 LDB2

3.16e-05192845c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellIPF-Endothelial-Lymphatic|IPF / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.16e-051928452496edd8f3a41146d418879de9ee2ccc7857431f
ToppCellControl-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.16e-05192845f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

MRC2 TRPS1 LRP1 LDB2 ITPR1

3.16e-0519284560b1312e84f6d6448365a952469c506c00b5fe93
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.23e-0519384525bdc557055b5bce6a21f8696b48e991c696b979
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NTN4 SGMS2 CACNA2D2 KCNK1 LRP2

3.23e-05193845fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellLAM-Endothelial-LymEndo|LAM / Condition, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.23e-0519384568eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCellCOPD-Endothelial-Lymphatic|COPD / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.23e-0519384518bcf08068a236c4575c7a07181ac893dfdcbeeb
ToppCellControl-Endothelial-Lymphatic|Control / Disease state, Lineage and Cell class

RELN PTPRB LAYN PKHD1L1 LDB2

3.23e-0519384564d19be73e5432d491436a01da5de5c926b615a9
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

MRC1 CHST15 TRPS1 LRP1 SIGLEC1

3.23e-0519384531c0978ba78c9516d498aec0798902e57555e557
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RELN LAYN CHST15 PKHD1L1 LDB2

3.23e-05193845040f6bb42aa41d0921371fdda1cc0912c4fe1930
Drugriluzole

GABRB1 GABRB3 NTN4 CACNA2D2 SCN4A KCNK1 ITPR1

2.92e-06174817CID000005070
Drugcoprogen

LRP1 LRP2 CPXM1

3.59e-069813CID006323272
DiseaseChildhood Absence Epilepsy

GABRB3 CACNA2D2

1.55e-047812C4281785
DiseaseEpilepsy, Minor

GABRB3 CACNA2D2

1.55e-047812C4552765
DiseaseAbsence Epilepsy

GABRB3 CACNA2D2

1.55e-047812C0014553
DiseaseAkinetic Petit Mal

GABRB3 CACNA2D2

1.55e-047812C0001890
DiseaseEpilepsy, Absence, Atypical

GABRB3 CACNA2D2

1.55e-047812C0751124
DiseaseAbsence Seizure Disorder

GABRB3 CACNA2D2

1.55e-047812C4553705
DiseaseJuvenile Absence Epilepsy

GABRB3 CACNA2D2

1.55e-047812C4317339
Diseaseosteosarcoma (is_marker_for)

PTPRB PRAME

4.03e-0411812DOID:3347 (is_marker_for)
Diseaseautistic disorder (is_marker_for)

GABRB1 RELN

4.83e-0412812DOID:12849 (is_marker_for)
DiseaseAutistic Disorder

GABRB1 GABRB3 RELN DRD1 TAF1C

7.72e-04261815C0004352
DiseaseHuntington's disease (biomarker_via_orthology)

DRD1 ITPR1

8.71e-0416812DOID:12858 (biomarker_via_orthology)
DiseaseManic

RELN DRD1 DNAH8

1.31e-0378813C0338831
Diseasedepressive disorder (implicated_via_orthology)

DRD1 RNF103

1.66e-0322812DOID:1596 (implicated_via_orthology)
Diseaseglioblastoma (is_implicated_in)

PTPRB ADGRB1

1.98e-0324812DOID:3068 (is_implicated_in)
DiseaseBipolar Disorder

GABRB1 GABRB3 RELN DRD1 DNAH8 ITPR1

2.02e-03477816C0005586
Diseasetaurine measurement

SLC35F3 KCNK1

2.32e-0326812EFO_0010536
Diseasediastolic blood pressure, systolic blood pressure

MRC1 ACAP1 MRC2 TRPS1 LRP1 PSMD1 SLC45A4

2.46e-03670817EFO_0006335, EFO_0006336
Diseaseamino acid measurement

PTPRB SCN4A KCNK1 LRP2 HMGCS2 MGAM2 FAM87A

2.62e-03678817EFO_0005134

Protein segments in the cluster

PeptideGeneStartEntry
FFLSSFCWVLTEAWQ

ADGRB2

1006

O60241
NRIRAWNWSNSITSS

ERICH6

516

Q7L0X2
SVTWYIAEFWNTVSN

ACER3

26

Q9NUN7
ATQGSFNSWDWVTRY

CNTNAP1

86

P78357
LWDSLGSQTSFQWTQ

CCDC116

221

Q8IYX3
FIRSTELDSNWSWFQ

ARFGAP3

61

Q9NP61
LSNFSVFWKSAWNVF

CATSPER2

166

Q96P56
AWWTSAAAWSLFQQL

CACNA2D2

971

Q9NY47
FFLSSFCWVLTEAWQ

ADGRB1

1021

O14514
FLAWNLSAVAASTEW

BTBD17

191

A6NE02
VQFSNDSRTWWGSRN

CPXM1

206

Q96SM3
ASNAFKTWSRRWFTI

ACAP1

276

Q15027
WNGWLSFQELFQFAS

ACSM4

196

P0C7M7
SFIRSTELDSNWNWF

ARFGAP2

61

Q8N6H7
NTFDVFVWFGWANSS

DRD1

311

P21728
RASNAFKTWNRRWFS

ACAP2

276

Q15057
QGRNSLWLSDWVTSY

CPXM2

211

Q8N436
ANSSAAWLVQFYSSW

QSOX2

76

Q6ZRP7
NWVFVTDTLNFSFWS

C9orf64

66

Q5T6V5
GSNRNTTDSLWFNWS

PTPRB

1181

P23467
LEYFTSNSWVWNTEN

FAR1

391

Q8WVX9
AFPDFFRNSTAAWWK

MGAM2

1336

Q2M2H8
YSWSESQDQVFLRWS

INTS1

1141

Q8N201
WCARNMSFWSSISFN

ITPR1

2276

Q14643
AWTDGSISQFRNWYV

LAYN

126

Q6UX15
DWVSRNLFWTSYDTN

LRP1

1666

Q07954
VAFPDFFRNSTAKWW

MGAM

2276

O43451
ASGNWNWDFTSALFF

KCNK1

96

O00180
SRTEDSDNLWWDAFA

LDB2

41

O43679
ASLFNAANWMESSSW

HMGCS2

171

P54868
LSFNAAFSQRWLAWE

PCNX1

1651

Q96RV3
NYTRLWANSTSSWDS

EVI2A

31

P22794
RVSWDSSTLGFWFTE

DNAH8

4311

Q96JB1
FNFQSTLSWREAWAS

MRC2

251

Q9UBG0
WTALQDLNSTGSFFW

MRC2

581

Q9UBG0
QSWYRSGETWDSKFS

DPP3

486

Q9NY33
VQLWSTYQVRSADWS

METTL23

126

Q86XA0
SWVSFWINYDASAAR

GABRB1

261

P18505
SWVSFWINYDASAAR

GABRB3

261

P28472
FWSDATQGKTWSAFQ

LRP2

1481

P98164
KTWSSATRFRWSQSY

RELN

1001

P78509
VCAISVFQFFSWWNS

DNAJC25

156

Q9H1X3
SSLSSSQYLQFKTWW

ERVK-5

356

Q9HDB9
SKLGSNFAEWSASWA

ATR

1481

Q13535
NFSFLPSQTSDWFWC

C17orf99

181

Q6UX52
FANSSWTRTDGLAWL

CD1D

36

P15813
YPRWDAWSNSRDSDS

CRYBB3

86

P26998
RQWESWSTEDKNTFF

CRAMP1

161

Q96RY5
NWESCSWSFFRSDEL

KLF17

316

Q5JT82
RASQSISSWLAWYQQ

IGKV1-5

46

P01602
VSYLSQNFITWAWDL

FAF1

401

Q9UNN5
YSNTTTLASWVRADW

RNF103

396

O00237
LRNWASFFVVFQAWS

FAM87A

156

P0C7U9
SSCAWTSDSRFFNLW

LINC00575

16

Q6W349
AFAWVSLNAWFWSTV

PGAP3

141

Q96FM1
LNSLSFNSGWQWSDR

MRC1

281

P22897
ATWDFEDSTTQSFRW

SYTL3

416

Q4VX76
FLNSATFWFCSWLSV

TAS2R41

91

P59536
LAFQWDFLNAATLWS

TAS2R60

96

P59551
TTLLLWFIWFSNAFS

SVOP

316

Q8N4V2
PFNDTNTTWYSNDTW

SCN4A

286

P35499
DFWTVWSGNRASLYS

PRAME

131

P78395
DSSFRFPRTWWQSAE

NTN4

96

Q9HB63
VFRDSSSWRWADFTA

TAF1C

381

Q15572
LRSSWDQVFAAFWQR

PRELID1

11

Q9Y255
EWLARATNWAKFTAT

PSMD1

391

Q99460
SFLLISWWYARADAN

MT-ND5

151

P03915
SWWYARADANTAAIQ

MT-ND5

156

P03915
FLSQFKLLWSQDSWT

METTL22

46

Q9BUU2
KVSSQTNFLSRAWWF

SGMS2

301

Q8NHU3
APFTLTWFATNWNFL

SLC35F3

96

Q8IY50
EASASTMWDNNAWTF

CHST15

346

Q7LFX5
VTSWNWVLLTDFASF

PIK3R4

156

Q99570
LDWTQTFLGSWFRTQ

SLC45A4

216

Q5BKX6
HNDFQSEADWLRFWS

TRPS1

1101

Q9UHF7
SWAEFSRFFDAWCQQ

ZSWIM9

26

Q86XI8
LQWEFQASNSETSWF

SLC16A5

41

O15375
SSREENWSFLDWDSR

SPEN

1456

Q96T58
NWSFLDWDSRFANFR

SPEN

1461

Q96T58
NFHASTSWYWRQSSD

NUFIP1

111

Q9UHK0
NVVWTFANNSSLWFT

TAS2R9

86

Q9NYW1
QTWAQREFFLPSESW

TEX52

36

A6NCN8
AESNWSLSQSFEWTF

TNKS1BP1

466

Q9C0C2
QNAEDWNLYWRTSSF

TTLL2

116

Q9BWV7
NSTFAWFWNDRRLHA

SIGLEC1

1476

Q9BZZ2
PATYNLWSNDSFWQS

PKHD1L1

3026

Q86WI1
LWSNDSFWQSSRENN

PKHD1L1

3031

Q86WI1
DYRWQWTSFLSAAST

TM9SF3

511

Q9HD45
ISQSRSWLTSSWNFN

PRR11

51

Q96HE9
FQWDLNAWTKSAEAF

TRIM28

391

Q13263
AAGVFSFSRLTWQWS

TMEM260

126

Q9NX78
SFSRLTWQWSIAAEV

TMEM260

131

Q9NX78