Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	MST1 EHMT2 KDM4C SUV39H1 EHMT1 MST1L KAT6B TRIM37	1.10e-07	229	51	8	GO:0140993
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	EHMT2 SUV39H1 EHMT1	1.86e-06	10	51	3	GO:0140947
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	EHMT2 SUV39H1 EHMT1	4.41e-06	13	51	3	GO:0046974
GeneOntologyMolecularFunction	H3K9me3 modified histone binding	KDM4C DPF2	3.82e-05	4	51	2	GO:0062072
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	EHMT2 EHMT1	9.53e-05	6	51	2	GO:0046976
GeneOntologyMolecularFunction	frizzled binding	WNT2 WNT8A WNT8B	1.68e-04	42	51	3	GO:0005109
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	EHMT2 EHMT1	1.77e-04	8	51	2	GO:0140948
GeneOntologyMolecularFunction	choline transmembrane transporter activity	SLC44A1 SLC44A5	1.77e-04	8	51	2	GO:0015220
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	EHMT2 SUV39H1 EHMT1	1.93e-04	44	51	3	GO:0140938
GeneOntologyMolecularFunction	zinc ion binding	LIMS1 EHMT2 KDM4C DPF3 SUV39H1 EHMT1 LHX5 ARIH1 TRIM37	3.79e-04	891	51	9	GO:0008270
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	EHMT2 SUV39H1 EHMT1	7.00e-04	68	51	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	EHMT2 SUV39H1 EHMT1	7.30e-04	69	51	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	EHMT2 SUV39H1 EHMT1	7.94e-04	71	51	3	GO:0042054
GeneOntologyMolecularFunction	C2H2 zinc finger domain binding	EHMT2 EHMT1	8.49e-04	17	51	2	GO:0070742
GeneOntologyMolecularFunction	p53 binding	EHMT2 EHMT1 PTTG1IP	1.01e-03	77	51	3	GO:0002039
GeneOntologyMolecularFunction	histone kinase activity	MST1 MST1L	2.32e-03	28	51	2	GO:0035173
GeneOntologyMolecularFunction	protein methyltransferase activity	EHMT2 SUV39H1 EHMT1	2.32e-03	103	51	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	EHMT2 SUV39H1 EHMT1	2.45e-03	105	51	3	GO:0008170
GeneOntologyMolecularFunction	transition metal ion binding	LIMS1 EHMT2 KDM4C DPF3 SUV39H1 EHMT1 LHX5 ARIH1 TRIM37	2.88e-03	1189	51	9	GO:0046914
GeneOntologyBiologicalProcess	labyrinthine layer blood vessel development	WNT2 PLCD1 ERVFRD-1	4.68e-05	29	50	3	GO:0060716
GeneOntologyBiologicalProcess	peptidyl-lysine dimethylation	EHMT2 EHMT1	5.73e-05	5	50	2	GO:0018027
GeneOntologyBiologicalProcess	response to fungicide	EHMT2 EHMT1	1.60e-04	8	50	2	GO:0060992
GeneOntologyBiologicalProcess	placenta blood vessel development	WNT2 PLCD1 ERVFRD-1	1.66e-04	44	50	3	GO:0060674
GeneOntologyBiologicalProcess	canonical Wnt signaling pathway	WNT2 WNT8A WNT8B NPHP4 TMEM64 EDNRB	1.76e-04	344	50	6	GO:0060070
GeneOntologyBiologicalProcess	positive regulation of mammary gland epithelial cell proliferation	MST1 MST1L	2.05e-04	9	50	2	GO:0033601
GeneOntologyBiologicalProcess	mammary duct terminal end bud growth	MST1 MST1L	2.05e-04	9	50	2	GO:0060763
GeneOntologyBiologicalProcess	choline transport	SLC44A1 SLC44A5	2.56e-04	10	50	2	GO:0015871
GeneOntologyBiologicalProcess	chordate embryonic development	LIMS1 DMRT2 MEGF8 KDM4C WNT2 WNT8A SUV39H1 PLCD1 ERVFRD-1	2.89e-04	906	50	9	GO:0043009
GeneOntologyBiologicalProcess	facultative heterochromatin formation	EHMT2 SUV39H1 EHMT1	3.22e-04	55	50	3	GO:0140718
GeneOntologyBiologicalProcess	macrophage chemotaxis	MST1 MST1L EDNRB	3.39e-04	56	50	3	GO:0048246
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	LIMS1 DMRT2 MEGF8 KDM4C WNT2 WNT8A SUV39H1 PLCD1 ERVFRD-1	3.48e-04	929	50	9	GO:0009792
GeneOntologyBiologicalProcess	chromatin remodeling	EHMT2 KDM4C DPF3 SUV39H1 EHMT1 DPF2 KAT6B TRIM37	3.77e-04	741	50	8	GO:0006338
Domain	PreSET	EHMT2 SUV39H1 EHMT1	6.66e-07	7	51	3	SM00468
Domain	Pre-SET	EHMT2 SUV39H1 EHMT1	6.66e-07	7	51	3	PF05033
Domain	Pre-SET_dom	EHMT2 SUV39H1 EHMT1	6.66e-07	7	51	3	IPR007728
Domain	PRE_SET	EHMT2 SUV39H1 EHMT1	6.66e-07	7	51	3	PS50867
Domain	Wnt8	WNT8A WNT8B	7.31e-06	2	51	2	IPR013301
Domain	Wnt	WNT2 WNT8A WNT8B	1.80e-05	19	51	3	IPR005817
Domain	Wnt_CS	WNT2 WNT8A WNT8B	1.80e-05	19	51	3	IPR018161
Domain	wnt	WNT2 WNT8A WNT8B	1.80e-05	19	51	3	PF00110
Domain	WNT1	WNT2 WNT8A WNT8B	1.80e-05	19	51	3	SM00097
Domain	WNT1	WNT2 WNT8A WNT8B	1.80e-05	19	51	3	PS00246
Domain	Requiem/DPF_N_dom	DPF3 DPF2	2.19e-05	3	51	2	IPR025750
Domain	Requiem_N	DPF3 DPF2	2.19e-05	3	51	2	PF14051
Domain	Znf_FYVE_PHD	KDM4C DPF3 ZFYVE26 DPF2 KAT6B	4.95e-05	147	51	5	IPR011011
Domain	PAN_AP	MST1 MST1L	7.27e-05	5	51	2	SM00473
Domain	Choline_transpo	SLC44A1 SLC44A5	7.27e-05	5	51	2	PF04515
Domain	Choline_transptr-like	SLC44A1 SLC44A5	7.27e-05	5	51	2	IPR007603
Domain	PHD	KDM4C DPF3 DPF2 KAT6B	1.01e-04	89	51	4	SM00249
Domain	Znf_PHD	KDM4C DPF3 DPF2 KAT6B	1.11e-04	91	51	4	IPR001965
Domain	ZF_PHD_2	KDM4C DPF3 DPF2 KAT6B	1.31e-04	95	51	4	PS50016
Domain	ZF_PHD_1	KDM4C DPF3 DPF2 KAT6B	1.36e-04	96	51	4	PS01359
Domain	Laminin_EGF	SCARF1 MEGF8 ATRNL1	1.51e-04	38	51	3	IPR002049
Domain	DM	DMRT2 DMRTA1	1.52e-04	7	51	2	PF00751
Domain	DM_2	DMRT2 DMRTA1	1.52e-04	7	51	2	PS50809
Domain	PAN	MST1 MST1L	1.52e-04	7	51	2	PS50948
Domain	DM	DMRT2 DMRTA1	1.52e-04	7	51	2	SM00301
Domain	Pan_app	MST1 MST1L	1.52e-04	7	51	2	IPR003609
Domain	-	DMRT2 DMRTA1	1.52e-04	7	51	2	4.10.1040.10
Domain	DM_1	DMRT2 DMRTA1	1.52e-04	7	51	2	PS40000
Domain	SPR	SPRY3 SPRY4	1.52e-04	7	51	2	PS51227
Domain	Sprouty	SPRY3 SPRY4	1.52e-04	7	51	2	IPR007875
Domain	PAN_1	MST1 MST1L	1.52e-04	7	51	2	PF00024
Domain	DM_DNA-bd	DMRT2 DMRTA1	1.52e-04	7	51	2	IPR001275
Domain	Sprouty	SPRY3 SPRY4	1.52e-04	7	51	2	PF05210
Domain	SET	EHMT2 SUV39H1 EHMT1	1.90e-04	41	51	3	PF00856
Domain	DMRT/dsx/mab-3	DMRT2 DMRTA1	2.03e-04	8	51	2	IPR026607
Domain	-	KDM4C DPF3 ZFYVE26 DPF2 ARIH1 KAT6B TRIM37	2.06e-04	449	51	7	3.30.40.10
Domain	PSI	MEGF8 ATRNL1 PTTG1IP	2.35e-04	44	51	3	IPR016201
Domain	Znf_RING/FYVE/PHD	KDM4C DPF3 ZFYVE26 DPF2 ARIH1 KAT6B TRIM37	2.35e-04	459	51	7	IPR013083
Domain	PSI	MEGF8 ATRNL1 PTTG1IP	2.68e-04	46	51	3	SM00423
Domain	SET	EHMT2 SUV39H1 EHMT1	2.68e-04	46	51	3	SM00317
Domain	SET_dom	EHMT2 SUV39H1 EHMT1	3.43e-04	50	51	3	IPR001214
Domain	SET	EHMT2 SUV39H1 EHMT1	3.43e-04	50	51	3	PS50280
Domain	Post-SET_dom	EHMT2 SUV39H1	8.56e-04	16	51	2	IPR003616
Domain	PostSET	EHMT2 SUV39H1	8.56e-04	16	51	2	SM00508
Domain	POST_SET	EHMT2 SUV39H1	8.56e-04	16	51	2	PS50868
Domain	LIM	LIMS1 LHX5 LHX8	8.85e-04	69	51	3	PF00412
Domain	-	LIMS1 LHX5 LHX8	9.23e-04	70	51	3	2.10.110.10
Domain	Znf_LIM	LIMS1 LHX5 LHX8	9.62e-04	71	51	3	IPR001781
Domain	LIM_DOMAIN_1	LIMS1 LHX5 LHX8	9.62e-04	71	51	3	PS00478
Domain	LIM_DOMAIN_2	LIMS1 LHX5 LHX8	9.62e-04	71	51	3	PS50023
Domain	LIM	LIMS1 LHX5 LHX8	9.62e-04	71	51	3	SM00132
Domain	Kringle	MST1 MST1L	9.68e-04	17	51	2	IPR000001
Domain	Kringle_CS	MST1 MST1L	9.68e-04	17	51	2	IPR018056
Domain	KRINGLE_2	MST1 MST1L	9.68e-04	17	51	2	PS50070
Domain	Kringle	MST1 MST1L	9.68e-04	17	51	2	PF00051
Domain	KRINGLE_1	MST1 MST1L	9.68e-04	17	51	2	PS00021
Domain	KR	MST1 MST1L	9.68e-04	17	51	2	SM00130
Domain	PHD	DPF3 DPF2 KAT6B	1.13e-03	75	51	3	PF00628
Domain	Znf_PHD-finger	DPF3 DPF2 KAT6B	1.31e-03	79	51	3	IPR019787
Domain	EGF_LAM_2	MEGF8 ATRNL1	3.03e-03	30	51	2	PS50027
Domain	EGF_LAM_1	MEGF8 ATRNL1	3.03e-03	30	51	2	PS01248
Domain	PSI	MEGF8 ATRNL1	3.44e-03	32	51	2	PF01437
Domain	Kringle-like	MST1 MST1L	3.44e-03	32	51	2	IPR013806
Domain	Plexin_repeat	MEGF8 ATRNL1	3.44e-03	32	51	2	IPR002165
Domain	Laminin_EGF	SCARF1 MEGF8	4.11e-03	35	51	2	PF00053
Domain	EGF_Lam	MEGF8 ATRNL1	4.11e-03	35	51	2	SM00180
Domain	-	MEGF8 ATRNL1	7.61e-03	48	51	2	2.120.10.80
Domain	CUB	MEGF8 ATRNL1	7.92e-03	49	51	2	PF00431
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT2 WNT8A WNT8B	1.44e-05	19	36	3	M47836
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT2 WNT8A WNT8B	3.38e-05	25	36	3	MM14940
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT2 WNT8A WNT8B	3.82e-05	26	36	3	M27239
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT2 WNT8A WNT8B	4.80e-05	28	36	3	M47835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	5.34e-05	29	36	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	5.34e-05	29	36	3	M47377
Pathway	WP_HISTONE_MODIFICATIONS	EHMT2 EHMT1	6.31e-05	5	36	2	MM15874
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	EHMT2 KDM4C SUV39H1 EHMT1 KAT6B	7.68e-05	175	36	5	MM14941
Pathway	BIOCARTA_WNT_LRP6_PATHWAY	WNT8A WNT8B	9.45e-05	6	36	2	MM1588
Pathway	BIOCARTA_WNT_LRP6_PATHWAY	WNT8A WNT8B	9.45e-05	6	36	2	M22083
Pathway	REACTOME_SIGNALING_BY_MST1	MST1 MST1L	9.45e-05	6	36	2	MM15492
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	1.12e-04	37	36	3	M47411
Pathway	KEGG_MELANOGENESIS	WNT2 WNT8A WNT8B EDNRB	1.23e-04	101	36	4	M7761
Pathway	BIOCARTA_MSP_PATHWAY	MST1 MST1L	1.32e-04	7	36	2	MM1580
Pathway	REACTOME_GPCR_LIGAND_BINDING	HTR5A WNT2 WNT8A WNT8B FSHB XK EDNRB	1.44e-04	463	36	7	M507
Pathway	WP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION	MST1 MST1L	1.76e-04	8	36	2	MM15986
Pathway	KEGG_LYSINE_DEGRADATION	EHMT2 SUV39H1 EHMT1	1.89e-04	44	36	3	M13720
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	2.02e-04	45	36	3	M47412
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	EHMT2 SUV39H1 EHMT1	2.15e-04	46	36	3	MM14933
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	2.15e-04	46	36	3	M47409
Pathway	REACTOME_SIGNALING_BY_GPCR	HTR5A RGS19 WNT2 WNT8A WNT8B FSHB XK EDNRB	3.17e-04	702	36	8	M746
Pathway	KEGG_BASAL_CELL_CARCINOMA	WNT2 WNT8A WNT8B	3.66e-04	55	36	3	M17807
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	3.86e-04	56	36	3	M1053
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	EHMT2 DPF3 SUV39H1 EHMT1 DPF2	4.36e-04	254	36	5	M27131
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	EHMT2 DPF3 EHMT1 DPF2	4.53e-04	142	36	4	M48257
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	EHMT2 KDM4C SUV39H1 EHMT1 KAT6B	5.95e-04	272	36	5	M29619
Pathway	WP_HISTONE_MODIFICATIONS	EHMT2 SUV39H1 EHMT1	5.99e-04	65	36	3	M39374
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	EHMT2 SUV39H1 EHMT1	7.44e-04	70	36	3	M27231
Pathway	BIOCARTA_SPRY_PATHWAY	SPRY3 SPRY4	8.42e-04	17	36	2	M1389
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION	EHMT2 EHMT1	9.46e-04	18	36	2	MM15342
Pathway	WP_PRIMARY_OVARIAN_INSUFFICIENCY	GPR3 FSHB LHX8 TRIM37	9.70e-04	174	36	4	M48058
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION	EHMT2 EHMT1	1.06e-03	19	36	2	M27639
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	WNT2 WNT8A WNT8B	1.31e-03	85	36	3	M48315
Pathway	WNT_SIGNALING	WNT2 WNT8A FSHB	1.49e-03	89	36	3	M5493
Pathway	WP_MTHFR_DEFICIENCY	EHMT2 EHMT1	1.69e-03	24	36	2	M39755
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	WNT2 WNT8A WNT8B	1.75e-03	94	36	3	M797
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	EHMT2 EHMT1	1.83e-03	25	36	2	MM15546
Pathway	REACTOME_SYNTHESIS_OF_PC	SLC44A1 SLC44A5	1.98e-03	26	36	2	MM14584
Pathway	KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES	EHMT2 EHMT1	2.14e-03	27	36	2	M47941
Pathway	REACTOME_SYNTHESIS_OF_PC	SLC44A1 SLC44A5	2.30e-03	28	36	2	M684
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	WNT8A WNT8B	2.81e-03	31	36	2	M27400
Pathway	WP_TUMOR_SUPPRESSOR_ACTIVITY_OF_SMARCB1	DPF3 DPF2	2.81e-03	31	36	2	M39522
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	WNT8A WNT8B	2.81e-03	31	36	2	MM15154
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	WNT2 WNT8A WNT8B	3.34e-03	118	36	3	M39852
Pathway	WP_ONECARBON_METABOLISM	EHMT2 EHMT1	3.38e-03	34	36	2	MM15859
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	EHMT2 EHMT1	3.38e-03	34	36	2	M27826
Pathway	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP	EHMT2 EHMT1	4.43e-03	39	36	2	MM14900
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	EHMT2 EHMT1	4.88e-03	41	36	2	M29748
Pathway	REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT	DPF3 DPF2 EDNRB	5.07e-03	137	36	3	M48232
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_PIGMENTATION	DPF3 DPF2	5.12e-03	42	36	2	M48237
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT2 NLRP3	5.61e-03	44	36	2	MM15878
Pathway	KEGG_WNT_SIGNALING_PATHWAY	WNT2 WNT8A WNT8B	6.64e-03	151	36	3	M19428
Pubmed	New nomenclature for chromatin-modifying enzymes.	EHMT2 KDM4C SUV39H1 EHMT1 KAT6B	2.19e-08	57	51	5	18022353
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	EHMT2 KDM4C SUV39H1 EHMT1	2.94e-08	22	51	4	28963472
Pubmed	SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.	EHMT2 SUV39H1 EHMT1	5.92e-08	6	51	3	23034801
Pubmed	Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.	EHMT2 SUV39H1 EHMT1	1.04e-07	7	51	3	24735877
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	EHMT2 KDM4C DPF3 EHMT1 DPF2 KAT6B	1.17e-07	157	51	6	30186101
Pubmed	Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.	WNT2 WNT8A WNT8B	2.48e-07	9	51	3	12702652
Pubmed	Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.	EHMT2 SUV39H1 EHMT1	3.54e-07	10	51	3	23333759
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	EHMT2 KDM4C EHMT1	4.86e-07	11	51	3	19144645
Pubmed	Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.	EHMT2 KDM4C EHMT1	4.86e-07	11	51	3	23748610
Pubmed	Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.	WNT2 WNT8A WNT8B	6.47e-07	12	51	3	16352730
Pubmed	Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.	EHMT2 SUV39H1 EHMT1	6.47e-07	12	51	3	21402781
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	EHMT2 KDM4C SUV39H1 EHMT1	8.27e-07	49	51	4	34368113
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT2 WNT8A WNT8B	1.33e-06	15	51	3	11429295
Pubmed	Wnt family proteins are secreted and associated with the cell surface.	WNT2 WNT8A WNT8B	1.99e-06	17	51	3	8167409
Pubmed	Evidence of a sex-dependent restrictive epigenome in schizophrenia.	EHMT2 EHMT1	2.11e-06	2	51	2	25935252
Pubmed	Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer.	EHMT2 EHMT1	2.11e-06	2	51	2	33283949
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	2.11e-06	2	51	2	29760744
Pubmed	Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.	EHMT2 EHMT1	2.11e-06	2	51	2	19531572
Pubmed	G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.	EHMT2 EHMT1	2.11e-06	2	51	2	18818694
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	2.11e-06	2	51	2	8393443
Pubmed	The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.	EHMT2 EHMT1	2.11e-06	2	51	2	18264113
Pubmed	A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP.	EHMT2 EHMT1	2.11e-06	2	51	2	28615290
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	2.11e-06	2	51	2	27609031
Pubmed	Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.	EHMT2 EHMT1	2.11e-06	2	51	2	31775874
Pubmed	Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.	EHMT2 EHMT1	2.11e-06	2	51	2	29554304
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	2.11e-06	2	51	2	24980820
Pubmed	Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.	EHMT2 EHMT1	2.11e-06	2	51	2	37894922
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	2.11e-06	2	51	2	31206688
Pubmed	Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.	EHMT2 EHMT1	2.11e-06	2	51	2	25637356
Pubmed	Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.	EHMT2 EHMT1	2.11e-06	2	51	2	25079219
Pubmed	G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells.	EHMT2 EHMT1	2.11e-06	2	51	2	27052169
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	2.11e-06	2	51	2	10728827
Pubmed	The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.	EHMT2 EHMT1	2.11e-06	2	51	2	33609736
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	2.11e-06	2	51	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	2.11e-06	2	51	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	2.11e-06	2	51	2	32017081
Pubmed	Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.	EHMT2 EHMT1	2.11e-06	2	51	2	32976761
Pubmed	Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells.	WNT8A WNT8B	2.11e-06	2	51	2	11956596
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	2.11e-06	2	51	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	2.11e-06	2	51	2	24409221
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	2.11e-06	2	51	2	27696525
Pubmed	Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.	EHMT2 EHMT1	2.11e-06	2	51	2	15774718
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	2.11e-06	2	51	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	2.11e-06	2	51	2	9486989
Pubmed	Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities.	EHMT2 EHMT1	2.11e-06	2	51	2	34619147
Pubmed	Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.	EHMT2 EHMT1	2.11e-06	2	51	2	25365549
Pubmed	EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.	EHMT2 EHMT1	2.11e-06	2	51	2	26320100
Pubmed	EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms.	EHMT2 EHMT1	2.11e-06	2	51	2	34954891
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	2.11e-06	2	51	2	33887258
Pubmed	GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death.	EHMT2 EHMT1	2.11e-06	2	51	2	29855824
Pubmed	Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells.	SPRY3 SPRY4	2.11e-06	2	51	2	31374860
Pubmed	Cerd4, third member of the d4 gene family: expression and organization of genomic locus.	DPF3 DPF2	2.11e-06	2	51	2	11845289
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	2.11e-06	2	51	2	25938541
Pubmed	Coronary Artery Formation Is Driven by Localized Expression of R-spondin3.	WNT2 WNT8A WNT8B	2.83e-06	19	51	3	28834739
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT2 WNT8A WNT8B	2.83e-06	19	51	3	11520664
Pubmed	The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.	WNT2 WNT8A WNT8B	3.88e-06	21	51	3	11914369
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT2 WNT8A WNT8B	5.15e-06	23	51	3	27362799
Pubmed	FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.	EHMT2 EHMT1	6.32e-06	3	51	2	29259012
Pubmed	Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.	DPF3 DPF2	6.32e-06	3	51	2	18765789
Pubmed	Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.	EHMT2 EHMT1	6.32e-06	3	51	2	23112189
Pubmed	IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.	SUV39H1 EHMT1	6.32e-06	3	51	2	31682228
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	6.32e-06	3	51	2	10225971
Pubmed	The d4 gene family in the human genome.	DPF3 DPF2	6.32e-06	3	51	2	8812431
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	6.32e-06	3	51	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	6.32e-06	3	51	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	6.32e-06	3	51	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	6.32e-06	3	51	2	26698664
Pubmed	Functional analysis of histone methyltransferase g9a in B and T lymphocytes.	EHMT2 EHMT1	6.32e-06	3	51	2	18566414
Pubmed	Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication.	EHMT2 SUV39H1	6.32e-06	3	51	2	17085482
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	6.32e-06	3	51	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	6.32e-06	3	51	2	27218122
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	6.32e-06	3	51	2	17395874
Pubmed	Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.	EHMT2 SUV39H1	6.32e-06	3	51	2	15788566
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	6.32e-06	3	51	2	24852423
Pubmed	Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1β production, VWF release and NET deposition in the myocardium.	VWF NLRP3	6.32e-06	3	51	2	38914598
Pubmed	CK2 downregulation induces senescence-associated heterochromatic foci formation through activating SUV39h1 and inactivating G9a.	EHMT2 SUV39H1	6.32e-06	3	51	2	30241941
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	6.32e-06	3	51	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	6.32e-06	3	51	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	6.32e-06	3	51	2	12606483
Pubmed	EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization.	EHMT2 SUV39H1	6.32e-06	3	51	2	19776757
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	6.32e-06	3	51	2	36623453
Pubmed	Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.	EHMT2 EHMT1	6.32e-06	3	51	2	27588951
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	6.32e-06	3	51	2	37184367
Pubmed	LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.	EHMT2 EHMT1	6.32e-06	3	51	2	21149390
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	6.32e-06	3	51	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	6.32e-06	3	51	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	6.32e-06	3	51	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	6.32e-06	3	51	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	6.32e-06	3	51	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	6.32e-06	3	51	2	35525373
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	6.32e-06	3	51	2	27510910
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	6.32e-06	3	51	2	31976559
Pubmed	The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.	EHMT2 EHMT1	6.32e-06	3	51	2	27893464
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	6.32e-06	3	51	2	32468668
Pubmed	Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.	EHMT2 EHMT1	6.32e-06	3	51	2	20005824
Pubmed	The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing.	EHMT2 EHMT1	6.32e-06	3	51	2	24389103
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	6.32e-06	3	51	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	6.32e-06	3	51	2	27465533
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	6.32e-06	3	51	2	30771091
Pubmed	Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.	EHMT2 EHMT1	6.32e-06	3	51	2	29860315
Interaction	H3-4 interactions	VWF EHMT2 DPF3 SUV39H1 EHMT1 DPF2 KAT6B TRIM37	1.54e-05	448	51	8	int:H3-4
Cytoband	1p31.1	SLC44A5 NEGR1 LHX8	7.42e-05	71	52	3	1p31.1
GeneFamily	Wnt family\|Endogenous ligands	WNT2 WNT8A WNT8B	6.30e-06	19	35	3	360
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EHMT2 SUV39H1 EHMT1	3.82e-05	34	35	3	487
GeneFamily	LIM class homeoboxes	LHX5 LHX8	2.37e-04	12	35	2	522
GeneFamily	PHD finger proteins	DPF3 DPF2 KAT6B	6.96e-04	90	35	3	88
GeneFamily	Solute carriers	SLC44A1 SLC44A5 SLC26A1 SLC16A12	6.88e-03	395	35	4	752
GeneFamily	Endogenous ligands	VWF WNT2 FSHB	1.07e-02	237	35	3	542
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related-OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	DMRT2 SYT17 SPRY4 CHIC1 EDNRB	3.53e-06	199	52	5	c0dc14fb9899d4263264347436de121814441dfb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	DMRT2 SYT17 SPRY4 CHIC1 EDNRB	3.53e-06	199	52	5	9bc53ff93ca97af4ee0f01c74a567987a26abb18
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC44A5 SPRY4 TRIM37 EDNRB	4.84e-05	172	52	4	c84cab89c97d647b8a256fd08e33d9102810febd
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SCARF1 SLC44A1 VWF HELB	4.84e-05	172	52	4	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	facs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF WNT2 TRIM37 EDNRB	5.06e-05	174	52	4	42dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCell	facs-Heart-RA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF WNT2 TRIM37 EDNRB	5.06e-05	174	52	4	f04edf2ca6788875c9918611e416fb739924382e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MST1 WNT8B LHX8	6.05e-05	65	52	3	8f7eac868f1605830cc97d9d1676f3ebff47d49b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MST1 WNT8B LHX8	6.05e-05	65	52	3	350f33bcc5924d7e3c3318391d33a984763fe206
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MST1 WNT8B LHX8	6.05e-05	65	52	3	c736a773a1b9cb16b51849a3bf0ccd9aeec7b342
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NEGR1 SYT17 ATRNL1 SPRY4	6.16e-05	183	52	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NEGR1 SYT17 ATRNL1 SPRY4	6.29e-05	184	52	4	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.42e-05	185	52	4	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.83e-05	188	52	4	05de6677f9bb4b00fed47f4b72f4a2cd507cb0f2
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCARF1 CEP68 SYT17 EDNRB	6.83e-05	188	52	4	524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell	5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCARF1 CEP68 SYT17 EDNRB	6.83e-05	188	52	4	d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	8ced0381ea042ba47680a02b617a2368fa2c54c8
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	e830fa0ddc3dccfaf9e88e8c416ed6aab12e3e3f
ToppCell	facs-Trachea-nan-18m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	5ced78f4b5c276b1bab24df807c00cf5ac8ed3d4
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	ecbe079606406f47d4fc97fe1670790dda8e10de
ToppCell	facs-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SPRY4 TRIM37 EDNRB	6.98e-05	189	52	4	e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEGR1 DPF3 WNT2 EDNRB	6.98e-05	189	52	4	3169476f98b7385706cb618c9ad64ae83a290ef0
ToppCell	facs-Trachea-18m-Endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	f635f3f13bced3bcf796cf55723a2df851f973fe
ToppCell	facs-Trachea-nan-18m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	2105d8b011b93a460237e00bc029efd7762dc8d5
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	1d4ad307c0606957dd7bf8da84450e5193cf4a50
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	403a82bb416aed13b9d31411ad17bdc4ce2a95fb
ToppCell	facs-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SPRY4 TRIM37 EDNRB	6.98e-05	189	52	4	5559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	b952026044d5f6c0adce60cf24f6e0199e6f8757
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	25781edbd08c6e413740b796ecc8ba1934bd3aa5
ToppCell	facs-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SPRY4 TRIM37 EDNRB	6.98e-05	189	52	4	f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCell	facs-Trachea-nan-18m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	6.98e-05	189	52	4	100eda87ac9c38dddcfa58408b057867a1738acb
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 SPRY4 TRIM37 EDNRB	7.27e-05	191	52	4	79b399496bd7322a1d53c43378f48695fd09a5d9
ToppCell	facs-Trachea-24m-Endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 SPRY4 TRIM37 EDNRB	7.27e-05	191	52	4	9c6d5d045781c6506ae80e318427ef1e0d87f45c
ToppCell	facs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF WNT2 TRIM37 EDNRB	7.27e-05	191	52	4	e518c598719119e60c76016c586b1520c258bbcb
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCARF1 SPRY4 TRIM37 EDNRB	7.27e-05	191	52	4	1b1e943709d0c3283a980c7c965ef1f110506a29
ToppCell	facs-Heart-RV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF WNT2 TRIM37 EDNRB	7.27e-05	191	52	4	f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 MST1 VWF EDNRB	7.41e-05	192	52	4	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.41e-05	192	52	4	945153c41dde6e90d103206955e1707b54eb0665
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.41e-05	192	52	4	6ab50579c63f31ca2cd41063a99b129f11c07510
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.56e-05	193	52	4	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.56e-05	193	52	4	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.56e-05	193	52	4	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	HSPCs-Mk_prog.\|HSPCs / Lineage and Cell class	SCARF1 LIMS1 VWF PTTG1IP	7.72e-05	194	52	4	5c05d508f5c29e6efe87506bf59e3b0fe5922f65
ToppCell	facs-Heart-LA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.72e-05	194	52	4	33cc4f1d716cb71d54cdedbe9bbdc0d7b17c4777
ToppCell	HSPCs-Mk_prog.\|World / Lineage and Cell class	SCARF1 LIMS1 VWF DPF2	7.72e-05	194	52	4	5049f4f102844d766eca577e809cf21f7908a9d2
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.87e-05	195	52	4	4db30b3bc65c25626f828cd4f867f20c71809898
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 VWF TRIM37 EDNRB	7.87e-05	195	52	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	5'-Adult-LymphNode-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCARF1 VWF WNT2 EDNRB	8.35e-05	198	52	4	d7e15e61b6018e4c36461c9471ee29601929925c
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	SPRY3 SLC44A1 KDM4C GSTCD	8.68e-05	200	52	4	c2df917900872453ea17a39928e39d071a6d3339
Drug	N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine	EHMT2 EHMT1	4.92e-06	2	51	2	ctd:C562047
Drug	7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	EHMT2 EHMT1	4.92e-06	2	51	2	ctd:C551961
Disease	Kleefstra syndrome 1 (implicated_via_orthology)	EHMT2 EHMT1	2.70e-06	2	49	2	DOID:0060352 (implicated_via_orthology)
Disease	viral infectious disease (implicated_via_orthology)	EHMT2 EHMT1	2.69e-05	5	49	2	DOID:934 (implicated_via_orthology)
Disease	nonanoylcarnitine (C9) measurement	SLC44A5 LHX8	4.04e-05	6	49	2	EFO_0800381
Disease	octanoylcarnitine measurement	SLC44A5 LHX8	9.65e-05	9	49	2	EFO_0021042
Disease	alopecia areata (is_marker_for)	EHMT2 KDM4C	1.21e-04	10	49	2	DOID:986 (is_marker_for)
Disease	Paroxysmal atrial fibrillation	CEP68 VWF DPF3 WNT8A	1.32e-04	156	49	4	C0235480
Disease	familial atrial fibrillation	CEP68 VWF DPF3 WNT8A	1.32e-04	156	49	4	C3468561
Disease	Persistent atrial fibrillation	CEP68 VWF DPF3 WNT8A	1.32e-04	156	49	4	C2585653
Disease	Atrial Fibrillation	CEP68 VWF DPF3 WNT8A	1.46e-04	160	49	4	C0004238
Disease	Hirschsprung's disease (is_implicated_in)	WNT8B EDNRB	1.47e-04	11	49	2	DOID:10487 (is_implicated_in)
Disease	hexanoylcarnitine measurement	SLC44A5 LHX8	1.76e-04	12	49	2	EFO_0021040
Disease	Chromosome Breaks	EHMT2 SUV39H1	2.43e-04	14	49	2	C0333704
Disease	Chromosome Breakage	EHMT2 SUV39H1	2.43e-04	14	49	2	C0376628
Disease	esophagus squamous cell carcinoma (is_marker_for)	EHMT2 KDM4C EHMT1	2.57e-04	74	49	3	DOID:3748 (is_marker_for)
Disease	sensorineural hearing loss (implicated_via_orthology)	ZMYND10 EDNRB	4.54e-04	19	49	2	DOID:10003 (implicated_via_orthology)
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L	7.91e-04	25	49	2	DOID:0050589 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVKTFCCQLEELICW	CEP68	626	Q76N32
CFKSCLCCWCQSFEE	EDNRB	396	P24530
ECNQACSCWRNCKNR	EHMT2	1016	Q96KQ7
ALRWQCIECKTCSAC	KAT6B	261	Q8WYB5
VCRNQNCKAEFCWVC	ARIH1	361	Q9Y4X5
CCSNQWLAAVLLSLC	NEGR1	11	Q7Z3B1
CSIKSCRVAACVWCN	MST1L	151	Q2TV78
WQCIECKSCILCGTS	DPF3	311	Q92784
SLQSCWAACCQDSAC	KIAA0319L	81	Q8IZA0
CEDCLANSSQCAWCQ	MEGF8	956	Q7Z7M0
CKRNAWTAECCLCNL	KDM4C	746	Q9H3R0
LDRAWHIKCVQCCEC	LHX5	21	Q9H2C1
NDLCWHVRCLSCSVC	LHX8	91	Q68G74
CCWKAICCNSCELTN	FSHB	11	P01225
NQDVQKVLWAVCCCC	GPR3	301	P46089
DCHQLVASWLVCLCC	NPHP4	1311	O75161
CQLCTEDKKCVWCSE	PTTG1IP2	56	P0DTF9
RALCKGCRCLELDCW	PLCD1	331	P51178
FCRWRDCQCANCLLV	DMRT2	141	Q9Y5R5
CRWRDCACAKCTLIA	DMRTA1	116	Q5VZB9
RRLCQLWIACDVLCC	HTR5A	111	P47898
SCKSCSLNLNCQWDQ	ATRNL1	721	Q5VV63
RCVLKSCICCLWCLE	SLC44A1	476	Q8WWI5
SCICCLWCLEKCLNY	SLC44A1	481	Q8WWI5
TLSKFLQCCLRCCFW	SLC44A5	546	Q8NCS7
LQCCLRCCFWCLENA	SLC44A5	551	Q8NCS7
RCCFWCLENAIKFLN	SLC44A5	556	Q8NCS7
CGIKSCREAACVWCN	MST1	181	P26927
NVKWLLCGCLCCCCT	CHIC1	141	Q5VXU3
LIFECNHACSCWRNC	EHMT1	1101	Q9H9B1
CLKACAEVSQWTRLC	GSTCD	136	Q8NEC7
KLLRCEASWIAFCQC	HELB	266	Q8NG08
KLWLVSCCLTSACCQ	NLRP3	831	Q96P20
LCWCCCCSCSWNQER	RGS19	41	P49795
LPSCWVCNQECLCSA	SPRY4	176	Q9C004
CWTCKKCICHQCALW	TRIM37	106	O94972
LLCRWTCRHCCQKCY	SYT17	21	Q9BSW7
SSLTKEWAQTCLCCC	SLC16A12	256	Q6ZSM3
EWAQTCLCCCLQQEY	SLC16A12	261	Q6ZSM3
ALNKAWCVNCFACST	LIMS1	266	P48059
WCVNCFACSTCNTKL	LIMS1	271	P48059
SCWLCNQRCLCSAES	SPRY3	166	O43610
CACCCWAPRSDLKDR	SCARF1	441	Q14162
CCKSSWNQLQDLCRL	SUV39H1	11	O43463
VSSCNCKFHWCCAVR	WNT8B	306	Q93098
VRNWRCCCLGSTCWC	TMEM64	106	Q6YI46
CKFHWCCAVRCQDCL	WNT2	326	P09544
KLCECKDCWRTFLNQ	ZNF846	196	Q147U1
CNTCVCQDRKWNCTD	VWF	846	P04275
CLALDEKCCFWVNQS	ERVFRD-1	431	P60508
LKARLWCSCSCSVLC	SLC26A1	31	Q9H2B4
WCSCSCSVLCVRALV	SLC26A1	36	Q9H2B4
RWQCIECKCCNICGT	DPF2	321	Q92785
KTCEECLKNVSCLWC	PTTG1IP	46	P53801
CLKNVSCLWCNTNKA	PTTG1IP	51	P53801
ASKRCSRCQNEWYCC	ZMYND10	401	O75800
TEVISSCNCKFQWCC	WNT8A	306	Q9H1J5
SCNCKFQWCCTVKCD	WNT8A	311	Q9H1J5
FQWCCTVKCDQCRHV	WNT8A	316	Q9H1J5
DLACSQCQLWKTCKQ	ZFYVE26	976	Q68DK2
WLRCFCWACRQQKPC	XK	391	P51811