Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	UBTFL6 UBTFL1	1.07e-04	9	35	2	GO:0001181
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	UBTFL6 UBTFL1	1.63e-04	11	35	2	GO:0001164
GeneOntologyMolecularFunction	general transcription initiation factor activity	UBTFL6 GTF3C5 UBTFL1	2.29e-04	68	35	3	GO:0140223
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	UBTFL6 UBTFL1	2.30e-04	13	35	2	GO:0001163
GeneOntologyMolecularFunction	cyclin binding	GAK CDK14	1.71e-03	35	35	2	GO:0030332
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	UBTFL6 TFB2M GTF3C5 NFKB1 UBTFL1	3.60e-05	231	34	5	GO:0006352
Domain	LEDGF	PSIP1 HDGFL2	3.41e-06	2	35	2	PF11467
Domain	LEDGF	PSIP1 HDGFL2	3.41e-06	2	35	2	IPR021567
Domain	PWWP	PSIP1 HDGFL2	6.35e-04	20	35	2	SM00293
Domain	PWWP	PSIP1 HDGFL2	8.42e-04	23	35	2	PF00855
Domain	PWWP_dom	PSIP1 HDGFL2	8.42e-04	23	35	2	IPR000313
Domain	PWWP	PSIP1 HDGFL2	9.18e-04	24	35	2	PS50812
Domain	IPT	PKHD1L1 NFKB1	1.16e-03	27	35	2	SM00429
Domain	TIG	PKHD1L1 NFKB1	1.53e-03	31	35	2	PF01833
Domain	IPT	PKHD1L1 NFKB1	1.63e-03	32	35	2	IPR002909
Domain	DnaJ	GAK DNAJC19	3.65e-03	48	35	2	PF00226
Domain	DnaJ	GAK DNAJC19	3.80e-03	49	35	2	SM00271
Domain	DNAJ_1	GAK DNAJC19	3.80e-03	49	35	2	PS00636
Domain	DNAJ_2	GAK DNAJC19	3.80e-03	49	35	2	PS50076
Domain	-	GAK DNAJC19	3.80e-03	49	35	2	1.10.287.110
Domain	DnaJ_domain	GAK DNAJC19	4.11e-03	51	35	2	IPR001623
Domain	HMG_box	UBTFL6 UBTFL1	4.43e-03	53	35	2	PF00505
Domain	HMG_BOX_2	UBTFL6 UBTFL1	4.59e-03	54	35	2	PS50118
Domain	HMG	UBTFL6 UBTFL1	4.59e-03	54	35	2	SM00398
Pubmed	Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.	PSIP1 HDGFL2	9.84e-07	2	35	2	16337983
Pubmed	LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.	PSIP1 HDGFL2	9.84e-07	2	35	2	31616795
Pubmed	HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.	PSIP1 HDGFL2	9.84e-07	2	35	2	23046603
Pubmed	Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.	PSIP1 HDGFL2	9.84e-07	2	35	2	15797927
Pubmed	Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.	PSIP1 HDGFL2	2.95e-06	3	35	2	33477970
Pubmed	CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.	UBTFL6 UBTFL1	2.95e-06	3	35	2	26092847
Pubmed	Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.	PSIP1 HDGFL2	2.95e-06	3	35	2	15371438
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	AGMAT HELZ APLP2 PTDSS2 TFB2M DPP8 GTF3C5 NFKB1 ATG2B	4.63e-06	1321	35	9	27173435
Pubmed	Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.	UBTFL6 UBTFL1	1.47e-05	6	35	2	19915186
Pubmed	Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.	PSIP1 HDGFL2	2.06e-05	7	35	2	26721387
Pubmed	Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.	BUD13 PHF20L1 HDGFL2	2.49e-05	56	35	3	26919559
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TNIK HELZ GAK PSIP1 HDGFL2 ECD ATG2B	3.43e-05	934	35	7	33916271
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	GAK GTF3C5 ECD ATG2B	6.51e-05	216	35	4	31519766
Pubmed	Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.	PSIP1 HDGFL2	1.02e-04	15	35	2	26367869
Pubmed	Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.	PTPRU EN1	1.02e-04	15	35	2	19515692
Pubmed	A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.	PSIP1 HDGFL2	1.33e-04	17	35	2	27783955
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	TNIK CIR1 DLG3 CDK14 HIBADH GTF3C5 NFKB1	2.04e-04	1242	35	7	30973865
Pubmed	PEG3 binds to H19-ICR as a transcriptional repressor.	TNIK APLP2	2.24e-04	22	35	2	27824289
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	PTPRU EN1	2.46e-04	23	35	2	20089898
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PYGB ABHD14B PCNX4 MAMLD1	3.01e-04	322	35	4	26514267
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TFB2M PSIP1 ABHD14B HDGFL2 DNAJC19 ISY1 ECD	4.49e-04	1415	35	7	28515276
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CIR1 HELZ TNRC18 TFB2M GTF3C5	4.75e-04	655	35	5	35819319
Pubmed	Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.	TFB2M NFKB1	6.07e-04	36	35	2	22421546
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	BUD13 EN1	7.12e-04	39	35	2	19010793
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TNIK PYGB HELZ DLG3 TNRC18 ATG2B	8.76e-04	1139	35	6	36417873
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	PYGB APLP2	9.90e-04	46	35	2	37207277
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	GAK DNAJC19	1.19e-03	49	19	2	584
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 PTPRU PKHD1L1 STAB1	1.37e-05	187	35	4	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 PTPRU PKHD1L1 STAB1	1.37e-05	187	35	4	d9943e65eedab73d141eae524e2411653a751705
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL\|Int-URO / Disease, condition lineage and cell class	TNIK DLG3 PSIP1 ABHD14B	1.71e-05	198	35	4	717735d755745439f97ba1b71785c73945dfa9c5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	APLP2 NFKB1 STAB1 MAMLD1	1.75e-05	199	35	4	379bbd9cecf466b902411c54d74bd9885285b1ba
Disease	Malignant neoplasm of salivary gland	PYGB EN1	1.24e-03	45	34	2	C0220636
Disease	Salivary Gland Neoplasms	PYGB EN1	1.35e-03	47	34	2	C0036095
Disease	triacylglycerol 52:2 measurement	BUD13 PTPRU	1.84e-03	55	34	2	EFO_0010414
Disease	uric acid measurement	TNIK AGMAT PYGB NFKB1	5.13e-03	610	34	4	EFO_0004761
Disease	Adenoid Cystic Carcinoma	PYGB EN1	5.94e-03	100	34	2	C0010606
Disease	non-high density lipoprotein cholesterol measurement	PYGB HELZ APLP2 HDGFL2	8.82e-03	713	34	4	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSQPPGKKAAHMYSG	BUD13	411	Q9BRD0
DLCQYMDKHPGGLHP	CDK14	216	O94921
NLKYKPGKGGVPAHM	ECD	61	O95905
YGDLQTPNKADMKPG	ATG2B	1366	Q96BY7
LIMKGAGHPCYLDKP	ABHD14B	181	Q96IU4
PELYHPMKKGSGVGE	APLP2	616	Q06481
GPDYGKVGPKMLDHE	ISY1	96	Q9ULR0
LGYPAVDKGKQEDMP	PCNX4	881	Q63HM2
MASGKQPAHKDFYPL	HELZ	886	P42694
KYPEHGNPAILLMGS	EN1	241	Q05925
KPGDLVFAKMKGYPH	HDGFL2	6	Q7Z4V5
KLHPMLGDPNADYIN	PTPRU	931	Q92729
PDKAAGQPYEQHAKM	GAK	1276	O14976
KGLKPMDHNGLADPY	DOC2B	151	Q14184
LYGMLYKPHDLQPGK	DPP8	646	Q6V1X1
AYPLVGHALLMKPDG	CYP4V2	56	Q6ZWL3
KPGSLHLNDMYAPPD	DLG3	311	Q92796
FPDMADGGYPNKIKR	MAMLD1	71	Q13495
YSAKEHGMPEKNPAE	PHF20L1	906	A8MW92
YDFMDDPKPHKKLGP	PTDSS2	366	Q9BVG9
KLMADPGNPDLYHVL	TFB2M	236	Q9H5Q4
YPILQAMAKKHGPVG	AGMAT	166	Q9BSE5
GNPMAKNLMKHGYPL	HIBADH	51	P31937
NGLNFMYEAPPGAKK	CIR1	66	Q86X95
KPGDLIFAKMKGYPH	PSIP1	6	O75475
KYMAGLNLHPHPGEA	TNRC18	51	O15417
YGAFIKKNPPGMDDQ	TNIK	86	Q9UKE5
AGLMHPYDGKVIPRN	nan	511	Q6ZTK2
GEPQKPPMNGYQKFH	UBTFL6	226	P0CB48
KFHGEPQKPPMNGYH	UBTFL1	216	P0CB47
IGGKAAPGYHMAKLI	PYGB	606	P11216
ENYHGDGMVCLPKDP	STAB1	261	Q9NY15
DNLYGLKLDHPNGDM	PKHD1L1	206	Q86WI1
GMKHGYAPSDLPVKA	GTF3C5	326	Q9Y5Q8
MLLNHPDKGGSPYIA	DNAJC19	86	Q96DA6
LNKMPHDYGQEGPLE	NFKB1	951	P19838