Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	TRIM46 FBXO40 TRAF6 RNF31 TRIM75 MBD1 BIRC2 ZNFX1 MIB2 TRIM24 PIAS2 CREBBP TRIM3 LIMS1 RNF146 TRIM8 PRICKLE2 TRIM55 HLTF UHRF1 PRKN KDM2A LTA4H ARHGEF2 TRIM40	9.72e-13	891	99	25	GO:0008270
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	6.30e-11	512	99	18	GO:0019787
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40	1.15e-10	398	99	16	GO:0061659
GeneOntologyMolecularFunction	aminoacyltransferase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	1.17e-10	532	99	18	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	1.62e-10	473	99	17	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 TRIM3 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40	4.44e-10	372	99	15	GO:0061630
GeneOntologyMolecularFunction	transition metal ion binding	TRIM46 FBXO40 TRAF6 RNF31 TRIM75 MBD1 BIRC2 ZNFX1 MIB2 TRIM24 PIAS2 CREBBP TRIM3 LIMS1 RNF146 TRIM8 PRICKLE2 TRIM55 HLTF UHRF1 PRKN KDM2A LTA4H ARHGEF2 TRIM40	4.73e-10	1189	99	25	GO:0046914
GeneOntologyMolecularFunction	acyltransferase activity	FBXO40 TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 CREBBP TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	7.19e-09	775	99	19	GO:0016746
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL6A3 VWF EFEMP2 DCN SSPOP EFEMP1 HMCN1 NID1	4.38e-06	188	99	8	GO:0005201
GeneOntologyMolecularFunction	unmethylated CpG binding	MBD1 KDM2A	1.07e-03	10	99	2	GO:0045322
GeneOntologyMolecularFunction	calcium ion binding	DSC3 EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 PLA2G5 NID1 NOTCH1	1.21e-03	749	99	11	GO:0005509
GeneOntologyMolecularFunction	store-operated calcium channel activity	TRPC4 TRPC5	1.55e-03	12	99	2	GO:0015279
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 KLHL22 RASSF5 RNF146 SOCS4 TRIM8 TRIM55 HLTF UHRF1 PRKN RAB40B TRIM40 OBI1	9.87e-10	893	98	21	GO:0032446
GeneOntologyBiologicalProcess	protein ubiquitination	TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 KLHL22 RASSF5 RNF146 SOCS4 TRIM8 TRIM55 HLTF UHRF1 PRKN RAB40B TRIM40 OBI1	1.17e-09	811	98	20	GO:0016567
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 KLHL22 RASSF5 RNF146 SOCS4 TRIM8 TRIM55 HLTF UHRF1 PRKN RAB40B TRIM40 OBI1	8.58e-09	1009	98	21	GO:0070647
GeneOntologyBiologicalProcess	tumor necrosis factor-mediated signaling pathway	TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 TNFRSF13C PRKN TNFRSF1B	9.48e-09	127	98	9	GO:0033209
GeneOntologyBiologicalProcess	post-translational protein modification	TRAF6 RNF31 TRIM75 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 KLHL22 RASSF5 RNF146 SOCS4 TRIM8 TRIM55 HLTF UHRF1 PRKN RAB40B TRIM40 OBI1	2.53e-08	1074	98	21	GO:0043687
GeneOntologyBiologicalProcess	cellular response to tumor necrosis factor	TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 TNFRSF13C PRKN ARHGEF2 TNFRSF1B	1.64e-07	233	98	10	GO:0071356
GeneOntologyBiologicalProcess	response to tumor necrosis factor	TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 TNFRSF13C PRKN ARHGEF2 TNFRSF1B	4.20e-07	258	98	10	GO:0034612
GeneOntologyBiologicalProcess	regulation of necroptotic process	RNF31 BIRC2 RBCK1 PRKN ARHGEF2	8.44e-07	37	98	5	GO:0060544
GeneOntologyBiologicalProcess	protein linear polyubiquitination	RNF31 RBCK1 PRKN	1.03e-06	5	98	3	GO:0097039
GeneOntologyBiologicalProcess	regulation of programmed necrotic cell death	RNF31 BIRC2 RBCK1 PRKN ARHGEF2	1.82e-06	43	98	5	GO:0062098
GeneOntologyBiologicalProcess	tube formation	TRAF6 SFRP2 TSC2 SALL1 EGF KDM2A IFT122 NOTCH1	3.08e-06	187	98	8	GO:0035148
GeneOntologyBiologicalProcess	cytokine-mediated signaling pathway	XCR1 TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 ACKR3 TNFRSF13C PRKN IL17RA TNFRSF1B NOTCH1	3.43e-06	577	98	13	GO:0019221
GeneOntologyBiologicalProcess	negative regulation of necroptotic process	RNF31 BIRC2 RBCK1 ARHGEF2	4.73e-06	24	98	4	GO:0060546
GeneOntologyBiologicalProcess	necroptotic process	RNF31 BIRC2 RBCK1 PRKN ARHGEF2	5.23e-06	53	98	5	GO:0070266
GeneOntologyBiologicalProcess	Wnt signaling pathway	SFRP2 TSC2 ISL1 MDFI SALL1 EGF CELSR2 RNF146 PRICKLE2 NID1 PRKN NOTCH1	6.10e-06	516	98	12	GO:0016055
GeneOntologyBiologicalProcess	negative regulation of programmed necrotic cell death	RNF31 BIRC2 RBCK1 ARHGEF2	6.61e-06	26	98	4	GO:0062099
GeneOntologyBiologicalProcess	positive regulation of canonical NF-kappaB signal transduction	TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 TRIM8 PRKN	8.05e-06	213	98	8	GO:0043123
GeneOntologyBiologicalProcess	protein polyubiquitination	TRAF6 RNF31 BIRC2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 PRKN	9.73e-06	289	98	9	GO:0000209
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	TRAF6 VWF RNF31 BIRC2 MIB2 DCN CREBBP TRIM3 RBCK1 KLHL22 LIMS1 EGF ACKR3 FSHR TRIM8 TRIM55 PLA2G5 PRKN NOTCH1	9.85e-06	1299	98	19	GO:1902533
GeneOntologyBiologicalProcess	neural tube closure	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	1.65e-05	113	98	6	GO:0001843
GeneOntologyBiologicalProcess	tube closure	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	1.74e-05	114	98	6	GO:0060606
GeneOntologyBiologicalProcess	programmed necrotic cell death	RNF31 BIRC2 RBCK1 PRKN ARHGEF2	1.80e-05	68	98	5	GO:0097300
GeneOntologyBiologicalProcess	negative regulation of neurogenesis	TRIM46 TRPC5 MBD1 TSC2 SLIT1 ARHGEF2 NOTCH1	1.88e-05	173	98	7	GO:0050768
GeneOntologyBiologicalProcess	epithelial tube formation	TRAF6 SFRP2 TSC2 SALL1 EGF KDM2A IFT122	1.88e-05	173	98	7	GO:0072175
GeneOntologyBiologicalProcess	primary neural tube formation	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	2.33e-05	120	98	6	GO:0014020
GeneOntologyBiologicalProcess	embryonic digit morphogenesis	SFRP2 CREBBP SALL1 IFT122 NOTCH1	2.71e-05	74	98	5	GO:0042733
GeneOntologyBiologicalProcess	canonical NF-kappaB signal transduction	TRAF6 RNF31 BIRC2 MIB2 CREBBP RBCK1 LIMS1 TRIM8 PRKN	2.78e-05	330	98	9	GO:0007249
GeneOntologyBiologicalProcess	negative regulation of nervous system development	TRIM46 TRPC5 MBD1 TSC2 SLIT1 ARHGEF2 NOTCH1	2.80e-05	184	98	7	GO:0051961
GeneOntologyBiologicalProcess	interleukin-17-mediated signaling pathway	TRAF6 IL17RA NOTCH1	2.87e-05	13	98	3	GO:0097400
GeneOntologyBiologicalProcess	protein K63-linked ubiquitination	TRAF6 BIRC2 TRIM3 TRIM8 PRKN	3.09e-05	76	98	5	GO:0070534
GeneOntologyBiologicalProcess	protein autoubiquitination	TRAF6 RNF146 UHRF1 PRKN OBI1	3.50e-05	78	98	5	GO:0051865
GeneOntologyBiologicalProcess	neural tube formation	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	4.33e-05	134	98	6	GO:0001841
GeneOntologyBiologicalProcess	neural tube development	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122 NOTCH1	5.07e-05	202	98	7	GO:0021915
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway	SFRP2 TSC2 ISL1 MDFI SALL1 EGF RNF146 PRKN NOTCH1	6.47e-05	368	98	9	GO:0030111
GeneOntologyBiologicalProcess	non-canonical NF-kappaB signal transduction	TRAF6 BIRC2 CREBBP RBCK1 TRIM55 TRIM40	8.12e-05	150	98	6	GO:0038061
GeneOntologyBiologicalProcess	regulation of canonical NF-kappaB signal transduction	TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 TRIM8 PRKN	8.83e-05	298	98	8	GO:0043122
GeneOntologyBiologicalProcess	negative regulation of epithelial cell proliferation	SFRP2 TSC2 ISL1 TRIM24 LIMS1 IFT122 NOTCH1	1.03e-04	226	98	7	GO:0050680
GeneOntologyBiologicalProcess	positive regulation of DNA binding	TRAF6 ISL1 EGF PRKN	1.09e-04	52	98	4	GO:0043388
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	1.12e-04	159	98	6	GO:0001838
GeneOntologyBiologicalProcess	protein monoubiquitination	BIRC2 KLHL22 PRKN OBI1	1.26e-04	54	98	4	GO:0006513
GeneOntologyBiologicalProcess	response to muramyl dipeptide	JAG1 ARHGEF2 NOTCH1	1.30e-04	21	98	3	GO:0032495
GeneOntologyBiologicalProcess	cardiac right ventricle morphogenesis	ISL1 JAG1 NOTCH1	1.30e-04	21	98	3	GO:0003215
GeneOntologyBiologicalProcess	negative regulation of extracellular matrix constituent secretion	TNFRSF1B NOTCH1	1.33e-04	4	98	2	GO:0003332
GeneOntologyBiologicalProcess	epithelial cell proliferation	SFRP2 TSC2 ISL1 TRIM24 LIMS1 EGF JAG1 FSHR UHRF1 IFT122 NOTCH1	1.36e-04	603	98	11	GO:0050673
GeneOntologyBiologicalProcess	regulation of smoothened signaling pathway	SALL3 ISL1 CREBBP SALL1 IFT122	1.45e-04	105	98	5	GO:0008589
GeneOntologyBiologicalProcess	regulation of epithelial cell proliferation	SFRP2 TSC2 ISL1 TRIM24 LIMS1 EGF JAG1 UHRF1 IFT122 NOTCH1	1.67e-04	514	98	10	GO:0050678
GeneOntologyBiologicalProcess	regulation of neurogenesis	TRIM46 TRPC5 MBD1 TSC2 PIAS2 SLIT1 HLTF ARHGEF2 TNFRSF1B NOTCH1	1.69e-04	515	98	10	GO:0050767
GeneOntologyBiologicalProcess	cellular response to cytokine stimulus	XCR1 TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 ACKR3 TNFRSF13C PRKN IL17RA ARHGEF2 TNFRSF1B NOTCH1	1.87e-04	967	98	14	GO:0071345
GeneOntologyBiologicalProcess	pulmonary valve development	JAG1 TNFRSF1B NOTCH1	1.96e-04	24	98	3	GO:0003177
GeneOntologyBiologicalProcess	cellular response to interleukin-17	TRAF6 IL17RA NOTCH1	1.96e-04	24	98	3	GO:0097398
GeneOntologyBiologicalProcess	regulation of neuron differentiation	SFRP2 TRPC5 ISL1 SALL1 JAG1 ARHGEF2 NOTCH1	2.16e-04	255	98	7	GO:0045664
GeneOntologyBiologicalProcess	regulation of DNA binding	TRAF6 ISL1 MDFI EGF PRKN	2.22e-04	115	98	5	GO:0051101
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	TRIM46 TRPC5 BIRC2 TSC2 ISL1 KLHL22 EFEMP1 SLIT1 PRKN ARHGEF2 TNFRSF1B NOTCH1 WDR44	2.23e-04	864	98	13	GO:0051129
GeneOntologyBiologicalProcess	protein catabolic process	BIRC2 TRIM24 ZNF416 TRIM3 RBCK1 KLHL22 EGF RNF146 SOCS4 UHRF1 PRKN IL17RA TNFRSF1B TRIM40 NOTCH1	2.40e-04	1115	98	15	GO:0030163
GeneOntologyBiologicalProcess	olfactory bulb interneuron differentiation	SALL3 SALL1 SLIT1	2.50e-04	26	98	3	GO:0021889
GeneOntologyBiologicalProcess	negative regulation of cell differentiation	TRIM46 SFRP2 TRPC5 MBD1 TSC2 ISL1 ZNF416 EFEMP1 SALL1 JAG1 SLIT1 ARHGEF2 NOTCH1	2.52e-04	875	98	13	GO:0045596
GeneOntologyBiologicalProcess	appendage morphogenesis	SFRP2 SALL3 CREBBP SALL1 IFT122 NOTCH1	2.55e-04	185	98	6	GO:0035107
GeneOntologyBiologicalProcess	limb morphogenesis	SFRP2 SALL3 CREBBP SALL1 IFT122 NOTCH1	2.55e-04	185	98	6	GO:0035108
GeneOntologyBiologicalProcess	regulation of non-canonical NF-kappaB signal transduction	BIRC2 CREBBP RBCK1 TRIM55 TRIM40	2.70e-04	120	98	5	GO:1901222
GeneOntologyBiologicalProcess	response to interleukin-17	TRAF6 IL17RA NOTCH1	2.80e-04	27	98	3	GO:0097396
GeneOntologyBiologicalProcess	regulation of DNA-binding transcription factor activity	TRAF6 RNF31 MDFI PIAS2 CREBBP RBCK1 TRIM8 ARHGEF2 TRIM40	2.88e-04	449	98	9	GO:0051090
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	TRAF6 SFRP2 TSC2 SALL1 KDM2A IFT122	2.94e-04	190	98	6	GO:0016331
GeneOntologyBiologicalProcess	inhibition of neuroepithelial cell differentiation	JAG1 NOTCH1	3.31e-04	6	98	2	GO:0002085
GeneOntologyBiologicalProcess	interleukin-17A-mediated signaling pathway	TRAF6 IL17RA	3.31e-04	6	98	2	GO:0038173
GeneOntologyBiologicalProcess	negative regulation of Wnt signaling pathway	SFRP2 TSC2 ISL1 MDFI PRKN NOTCH1	3.38e-04	195	98	6	GO:0030178
GeneOntologyBiologicalProcess	negative regulation of intrinsic apoptotic signaling pathway	SFRP2 NDUFS3 ACKR3 PRKN ARHGEF2	3.51e-04	127	98	5	GO:2001243
GeneOntologyBiologicalProcess	regulation of epithelial to mesenchymal transition	SFRP2 TSC2 ISL1 JAG1 NOTCH1	3.91e-04	130	98	5	GO:0010717
GeneOntologyBiologicalProcess	epithelial to mesenchymal transition	SFRP2 TSC2 ISL1 LIMS1 JAG1 NOTCH1	4.19e-04	203	98	6	GO:0001837
GeneOntologyBiologicalProcess	positive regulation of apoptotic process involved in morphogenesis	TNFRSF1B NOTCH1	4.62e-04	7	98	2	GO:1902339
GeneOntologyBiologicalProcess	central nervous system development	SFRP2 SALL3 TRPC4 MBD1 ISL1 NDUFS3 SALL1 EGF CELSR2 ACKR3 SLIT1 PRKN IFT122 TNFRSF1B NOTCH1	5.10e-04	1197	98	15	GO:0007417
GeneOntologyBiologicalProcess	negative regulation of cell growth	TRIM46 SFRP2 ZNF416 NDUFS3 SLIT1 TRIM40	5.27e-04	212	98	6	GO:0030308
GeneOntologyBiologicalProcess	developmental growth involved in morphogenesis	TRIM46 SFRP2 TRPC5 SALL1 SLIT1 PRKN NOTCH1	5.63e-04	299	98	7	GO:0060560
GeneOntologyBiologicalProcess	response to cytokine	XCR1 TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 ACKR3 TNFRSF13C PRKN IL17RA ARHGEF2 TNFRSF1B NOTCH1	5.88e-04	1083	98	14	GO:0034097
GeneOntologyBiologicalProcess	negative regulation of multicellular organismal process	TRIM46 SFRP2 TRPC5 MBD1 TSC2 DCN CREBBP ZNF416 KLHL22 RASSF5 EFEMP1 SLIT1 FSHR PLA2G5 ARHGEF2 TNFRSF1B NOTCH1	6.03e-04	1488	98	17	GO:0051241
GeneOntologyBiologicalProcess	positive regulation of apoptotic process involved in development	TNFRSF1B NOTCH1	6.14e-04	8	98	2	GO:1904747
GeneOntologyBiologicalProcess	negative regulation of developmental process	TRIM46 SFRP2 TRPC5 MBD1 TSC2 ISL1 DCN ZNF416 EFEMP1 SALL1 JAG1 SLIT1 PRKN ARHGEF2 NOTCH1	6.21e-04	1220	98	15	GO:0051093
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	TRIM46 SFRP2 TRPC5 TSC2 ISL1 DCN PIAS2 SALL1 EGF JAG1 SLIT1 TNFRSF13C PRKN NOTCH1	6.26e-04	1090	98	14	GO:0022603
GeneOntologyBiologicalProcess	response to peptide	XCR1 TRAF6 RNF31 BIRC2 MIB2 RBCK1 LIMS1 ACKR3 TNFRSF13C PRKN IL17RA ARHGEF2 TNFRSF1B NOTCH1	6.85e-04	1100	98	14	GO:1901652
GeneOntologyBiologicalProcess	regulation of extracellular matrix organization	EFEMP2 NID1 TNFRSF1B NOTCH1	6.91e-04	84	98	4	GO:1903053
GeneOntologyBiologicalProcess	limb development	SFRP2 SALL3 CREBBP SALL1 IFT122 NOTCH1	7.03e-04	224	98	6	GO:0060173
GeneOntologyBiologicalProcess	appendage development	SFRP2 SALL3 CREBBP SALL1 IFT122 NOTCH1	7.03e-04	224	98	6	GO:0048736
GeneOntologyBiologicalProcess	embryonic limb morphogenesis	SFRP2 CREBBP SALL1 IFT122 NOTCH1	7.06e-04	148	98	5	GO:0030326
GeneOntologyBiologicalProcess	embryonic appendage morphogenesis	SFRP2 CREBBP SALL1 IFT122 NOTCH1	7.06e-04	148	98	5	GO:0035113
GeneOntologyBiologicalProcess	positive regulation of NF-kappaB transcription factor activity	TRAF6 RNF31 RBCK1 TRIM8 ARHGEF2	7.73e-04	151	98	5	GO:0051092
GeneOntologyBiologicalProcess	regulation of nervous system development	TRIM46 TRPC5 MBD1 TSC2 PIAS2 SLIT1 HLTF ARHGEF2 TNFRSF1B NOTCH1	7.76e-04	625	98	10	GO:0051960
GeneOntologyBiologicalProcess	positive regulation of cardiac epithelial to mesenchymal transition	JAG1 NOTCH1	7.87e-04	9	98	2	GO:0062043
GeneOntologyBiologicalProcess	regulation of cell growth	TRIM46 SFRP2 TRPC5 ZNF416 NDUFS3 KLHL22 SLIT1 PRKN TRIM40	8.17e-04	519	98	9	GO:0001558
GeneOntologyBiologicalProcess	cardiac ventricle morphogenesis	SFRP2 ISL1 JAG1 NOTCH1	8.23e-04	88	98	4	GO:0003208
GeneOntologyBiologicalProcess	tube morphogenesis	TRAF6 SFRP2 THSD7A EFEMP2 TSC2 ISL1 DCN SALL1 EGF ACKR3 JAG1 KDM2A IFT122 NOTCH1	8.52e-04	1125	98	14	GO:0035239
GeneOntologyBiologicalProcess	tissue morphogenesis	TRAF6 SFRP2 EFEMP2 TSC2 ISL1 SALL1 EGF JAG1 KDM2A IFT122 NOTCH1	8.63e-04	750	98	11	GO:0048729
GeneOntologyBiologicalProcess	negative regulation of cell projection organization	TRIM46 TRPC5 TSC2 EFEMP1 SLIT1 WDR44	8.63e-04	233	98	6	GO:0031345
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	TRAF6 SFRP2 TSC2 SALL1 EGF KDM2A IFT122 NOTCH1	8.95e-04	421	98	8	GO:0060562
GeneOntologyBiologicalProcess	tube development	TRAF6 SFRP2 THSD7A EFEMP2 TSC2 ISL1 DCN SALL1 EGF ACKR3 JAG1 KDM2A LTA4H IFT122 HECA NOTCH1	9.00e-04	1402	98	16	GO:0035295
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process	BIRC2 ZNF416 TRIM3 RBCK1 KLHL22 EGF RNF146 SOCS4 UHRF1 PRKN	9.29e-04	640	98	10	GO:0006511
GeneOntologyBiologicalProcess	heart development	SFRP2 MBD1 TSC2 ISL1 ZNF416 SALL1 JAG1 KDM2A IFT122 TNFRSF1B NOTCH1	9.30e-04	757	98	11	GO:0007507
GeneOntologyBiologicalProcess	positive regulation of macroautophagy	RNF31 TSC2 DCN PRKN	9.72e-04	92	98	4	GO:0016239
GeneOntologyBiologicalProcess	aorta morphogenesis	EFEMP2 JAG1 NOTCH1	9.73e-04	41	98	3	GO:0035909
GeneOntologyBiologicalProcess	regulation of extracellular matrix constituent secretion	TNFRSF1B NOTCH1	9.81e-04	10	98	2	GO:0003330
GeneOntologyBiologicalProcess	distal tubule development	JAG1 NOTCH1	9.81e-04	10	98	2	GO:0072017
GeneOntologyBiologicalProcess	cardiac ventricle development	SFRP2 ISL1 SALL1 JAG1 NOTCH1	1.03e-03	161	98	5	GO:0003231
GeneOntologyCellularComponent	CD40 receptor complex	TRAF6 RNF31 BIRC2	1.65e-05	11	99	3	GO:0035631
GeneOntologyCellularComponent	extracellular matrix	COL6A3 SFRP2 VWF EFEMP2 MUC5B DCN SSPOP FCGBP EFEMP1 HMCN1 NID1 OTOG	6.31e-05	656	99	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL6A3 SFRP2 VWF EFEMP2 MUC5B DCN SSPOP FCGBP EFEMP1 HMCN1 NID1 OTOG	6.49e-05	658	99	12	GO:0030312
GeneOntologyCellularComponent	collagen type VI trimer	COL6A3 DCN	6.64e-05	3	99	2	GO:0005589
GeneOntologyCellularComponent	collagen beaded filament	COL6A3 DCN	6.64e-05	3	99	2	GO:0098647
GeneOntologyCellularComponent	LUBAC complex	RNF31 RBCK1	1.32e-04	4	99	2	GO:0071797
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL6A3 SFRP2 VWF EFEMP2 DCN SSPOP EFEMP1 HMCN1 NID1	9.27e-04	530	99	9	GO:0062023
Domain	ZF_RING_1	TRIM46 TRAF6 RNF31 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	2.83e-12	291	99	16	PS00518
Domain	ZF_RING_2	TRIM46 TRAF6 RNF31 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 PRKN TRIM40 OBI1	4.06e-12	298	99	16	PS50089
Domain	Znf_RING_CS	TRIM46 TRAF6 RNF31 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 TRIM40	6.23e-11	163	99	12	IPR017907
Domain	RING	TRIM46 TRAF6 RNF31 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 TRIM40 OBI1	6.97e-11	305	99	15	SM00184
Domain	Znf_RING	TRIM46 TRAF6 RNF31 BIRC2 MIB2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 TRIM40 OBI1	1.77e-10	326	99	15	IPR001841
Domain	EGF_3	EFEMP2 ADAM29 SSPOP EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 OTOG PEAR1	3.38e-10	235	99	13	PS50026
Domain	VWC_out	VWF MUC5B SSPOP FCGBP JAG1 OTOG	4.88e-10	19	99	6	SM00215
Domain	EGF-like_dom	EFEMP2 ADAM29 FCGBP EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 OTOG PEAR1	6.88e-10	249	99	13	IPR000742
Domain	Znf_RING/FYVE/PHD	TRIM46 TRAF6 BIRC2 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 KDM2A TRIM40 OBI1	2.38e-09	459	99	16	IPR013083
Domain	TIL	VWF MUC5B SSPOP FCGBP OTOG	2.91e-09	12	99	5	PF01826
Domain	C8	VWF MUC5B SSPOP FCGBP OTOG	2.91e-09	12	99	5	PF08742
Domain	Unchr_dom_Cys-rich	VWF MUC5B SSPOP FCGBP OTOG	4.70e-09	13	99	5	IPR014853
Domain	C8	VWF MUC5B SSPOP FCGBP OTOG	4.70e-09	13	99	5	SM00832
Domain	EGF-type_Asp/Asn_hydroxyl_site	EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1	4.90e-09	106	99	9	IPR000152
Domain	TIL_dom	VWF MUC5B SSPOP FCGBP OTOG	7.28e-09	14	99	5	IPR002919
Domain	EGF_1	EFEMP2 ADAM29 SSPOP EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 PEAR1	1.05e-08	255	99	12	PS00022
Domain	-	TRIM46 TRAF6 MIB2 TRIM24 PIAS2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 KDM2A TRIM40 OBI1	1.39e-08	449	99	15	3.30.40.10
Domain	VWD	VWF MUC5B SSPOP FCGBP OTOG	1.58e-08	16	99	5	SM00216
Domain	VWF_type-D	VWF MUC5B SSPOP FCGBP OTOG	1.58e-08	16	99	5	IPR001846
Domain	VWFD	VWF MUC5B SSPOP FCGBP OTOG	1.58e-08	16	99	5	PS51233
Domain	VWD	VWF MUC5B SSPOP FCGBP OTOG	1.58e-08	16	99	5	PF00094
Domain	EGF_2	EFEMP2 ADAM29 SSPOP EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 PEAR1	1.61e-08	265	99	12	PS01186
Domain	EGF_CA	EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1	1.70e-08	122	99	9	SM00179
Domain	EGF-like_Ca-bd_dom	EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1	1.96e-08	124	99	9	IPR001881
Domain	zf-C3HC4	TRIM46 TRAF6 BIRC2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 TRIM40 OBI1	2.76e-08	223	99	11	PF00097
Domain	EGF_Ca-bd_CS	EFEMP2 EFEMP1 EGF HMCN1 JAG1 SLIT1 NID1 NOTCH1	4.59e-08	97	99	8	IPR018097
Domain	EGF	EFEMP2 FCGBP EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 PEAR1	4.72e-08	235	99	11	SM00181
Domain	EGF_CA	EFEMP2 EFEMP1 EGF HMCN1 JAG1 SLIT1 NID1 NOTCH1	5.38e-08	99	99	8	PS01187
Domain	ASX_HYDROXYL	EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 NID1 NOTCH1	5.83e-08	100	99	8	PS00010
Domain	VWF_dom	VWF MUC5B SSPOP FCGBP JAG1 OTOG	8.56e-08	42	99	6	IPR001007
Domain	EGF-like_CS	EFEMP2 ADAM29 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1 PEAR1	1.37e-07	261	99	11	IPR013032
Domain	Growth_fac_rcpt_	EFEMP2 EFEMP1 EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1	1.43e-07	156	99	9	IPR009030
Domain	Cys_knot_C	VWF MUC5B SSPOP SLIT1 OTOG	1.85e-07	25	99	5	IPR006207
Domain	CTCK_2	VWF MUC5B SSPOP SLIT1 OTOG	1.85e-07	25	99	5	PS01225
Domain	ZF_BBOX	TRIM46 TRIM24 TRIM3 RBCK1 TRIM8 TRIM55 TRIM40	2.20e-07	80	99	7	PS50119
Domain	Znf_B-box	TRIM46 TRIM24 TRIM3 RBCK1 TRIM8 TRIM55 TRIM40	2.39e-07	81	99	7	IPR000315
Domain	EGF_CA	EFEMP2 EFEMP1 EGF HMCN1 JAG1 NID1 NOTCH1	3.62e-07	86	99	7	PF07645
Domain	VWC	VWF MUC5B SSPOP FCGBP JAG1	1.65e-06	38	99	5	SM00214
Domain	-	TRIM46 TRIM24 TRIM3 TRIM8 TRIM55 TRIM40	2.06e-06	71	99	6	4.10.45.10
Domain	CTCK_1	VWF MUC5B SSPOP SLIT1	2.15e-06	18	99	4	PS01185
Domain	EGF	EGF CELSR2 HMCN1 JAG1 SLIT1 NID1 NOTCH1	4.79e-06	126	99	7	PF00008
Domain	CT	VWF MUC5B SLIT1 OTOG	5.05e-06	22	99	4	SM00041
Domain	cEGF	EFEMP2 EFEMP1 HMCN1 NID1	1.02e-05	26	99	4	IPR026823
Domain	cEGF	EFEMP2 EFEMP1 HMCN1 NID1	1.02e-05	26	99	4	PF12662
Domain	hEGF	CELSR2 JAG1 SLIT1 NOTCH1	1.38e-05	28	99	4	PF12661
Domain	-	EGF HMCN1 NID1	2.31e-05	11	99	3	2.40.155.10
Domain	GFP-like	EGF HMCN1 NID1	2.31e-05	11	99	3	IPR023413
Domain	Znf-RING_LisH	TRIM46 TRIM3 RBCK1 TRIM55	3.05e-05	34	99	4	IPR027370
Domain	zf-RING_UBOX	TRIM46 TRIM3 RBCK1 TRIM55	3.05e-05	34	99	4	PF13445
Domain	Znf_C3HC4_RING-type	TRIM46 TRAF6 TRIM3 RBCK1 TRIM8 TRIM55 TRIM40	3.63e-05	172	99	7	IPR018957
Domain	IBR	RNF31 RBCK1 PRKN	5.04e-05	14	99	3	PF01485
Domain	IBR_dom	RNF31 RBCK1 PRKN	6.28e-05	15	99	3	IPR002867
Domain	G2F	HMCN1 NID1	8.32e-05	3	99	2	SM00682
Domain	GFP	HMCN1 NID1	1.66e-04	4	99	2	IPR009017
Domain	G2F	HMCN1 NID1	1.66e-04	4	99	2	PF07474
Domain	G2_nidogen/fibulin_G2F	HMCN1 NID1	1.66e-04	4	99	2	IPR006605
Domain	NIDOGEN_G2	HMCN1 NID1	1.66e-04	4	99	2	PS50993
Domain	TRP_dom	TRPC4 TRPC5	4.11e-04	6	99	2	IPR013555
Domain	TRP_2	TRPC4 TRPC5	4.11e-04	6	99	2	PF08344
Domain	BBOX	TRIM46 TRIM24 TRIM3 TRIM55	4.93e-04	69	99	4	SM00336
Domain	TRPC_channel	TRPC4 TRPC5	5.74e-04	7	99	2	IPR002153
Domain	zf-B_box	TRIM46 TRIM24 TRIM3 TRIM55	5.80e-04	72	99	4	PF00643
Domain	TNFR/NGFR_Cys_rich_reg	CELSR2 TNFRSF13C TNFRSF1B	7.02e-04	33	99	3	IPR001368
Domain	VWFC_1	VWF MUC5B SSPOP	9.08e-04	36	99	3	PS01208
Domain	VWFC_2	VWF MUC5B SSPOP	1.07e-03	38	99	3	PS50184
Domain	-	TRIM3 EGF NID1	1.15e-03	39	99	3	2.120.10.30
Domain	LRR_5	FSHR LRRC8B	1.22e-03	10	99	2	PF13306
Domain	LRR_5	FSHR LRRC8B	1.22e-03	10	99	2	IPR026906
Domain	TRP_channel	TRPC4 TRPC5	1.48e-03	11	99	2	IPR004729
Domain	Fol_N	FCGBP SLIT1	1.48e-03	11	99	2	IPR003645
Domain	Znf_CXXC	MBD1 KDM2A	1.48e-03	11	99	2	IPR002857
Domain	ZF_CXXC	MBD1 KDM2A	1.48e-03	11	99	2	PS51058
Domain	zf-CXXC	MBD1 KDM2A	1.48e-03	11	99	2	PF02008
Domain	FOLN	FCGBP SLIT1	1.48e-03	11	99	2	SM00274
Domain	COS_domain	TRIM46 TRIM55	1.77e-03	12	99	2	IPR017903
Domain	COS	TRIM46 TRIM55	1.77e-03	12	99	2	PS51262
Domain	Znf_TRAF	FBXO40 TRAF6	1.77e-03	12	99	2	IPR001293
Domain	6-blade_b-propeller_TolB-like	TRIM3 EGF NID1	1.86e-03	46	99	3	IPR011042
Domain	ZF_TRAF	FBXO40 TRAF6	2.09e-03	13	99	2	PS50145
Domain	-	KBTBD3 KLHL22 FBXO42	2.10e-03	48	99	3	2.120.10.80
Domain	IBR	RNF31 PRKN	2.43e-03	14	99	2	SM00647
Domain	Ldl_recept_b	EGF NID1	2.43e-03	14	99	2	PF00058
Domain	LDLRB	EGF NID1	2.43e-03	14	99	2	PS51120
Domain	-	FBXO40 TRAF6	2.43e-03	14	99	2	3.90.890.10
Domain	Bbox_C	TRIM24 TRIM3	2.79e-03	15	99	2	IPR003649
Domain	BBC	TRIM24 TRIM3	2.79e-03	15	99	2	SM00502
Domain	LY	EGF NID1	2.79e-03	15	99	2	SM00135
Domain	LDLR_classB_rpt	EGF NID1	2.79e-03	15	99	2	IPR000033
Domain	LRRNT	DCN SLIT1 FSHR	2.79e-03	53	99	3	PF01462
Domain	UBIQUITIN_2	RBCK1 UHRF1 PRKN	2.95e-03	54	99	3	PS50053
Domain	Kelch-typ_b-propeller	KBTBD3 KLHL22 FBXO42	3.10e-03	55	99	3	IPR015915
Domain	SIAH-type	FBXO40 TRAF6	3.18e-03	16	99	2	IPR013323
Domain	EMI	SSPOP PEAR1	3.59e-03	17	99	2	PS51041
Domain	Ubiquitin_dom	RBCK1 UHRF1 PRKN	3.61e-03	58	99	3	IPR000626
Domain	Gal_Oxase/kelch_b-propeller	KBTBD3 KLHL22 FBXO42	3.79e-03	59	99	3	IPR011043
Domain	ZZ	MIB2 CREBBP	4.03e-03	18	99	2	PF00569
Domain	ZF_ZZ_2	MIB2 CREBBP	4.03e-03	18	99	2	PS50135
Domain	ZF_ZZ_1	MIB2 CREBBP	4.03e-03	18	99	2	PS01357
Domain	Znf_ZZ	MIB2 CREBBP	4.48e-03	19	99	2	IPR000433
Domain	ZnF_ZZ	MIB2 CREBBP	4.48e-03	19	99	2	SM00291
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	RNF31 BIRC2 MIB2 RBCK1	7.46e-06	23	79	4	MM15177
Pathway	REACTOME_SIGNALING_BY_NOTCH3	MIB2 CREBBP EGF JAG1 NOTCH1	7.65e-06	49	79	5	M618
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	RNF31 BIRC2 MIB2 RBCK1	1.06e-05	25	79	4	M27435
Pathway	REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES	CREBBP EGF NOTCH1	2.71e-05	11	79	3	M48021
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	CREBBP JAG1 NOTCH1	5.90e-05	14	79	3	M27808
Pathway	BIOCARTA_RELA_PATHWAY	TRAF6 CREBBP TNFRSF1B	7.34e-05	15	79	3	MM1339
Pathway	BIOCARTA_RELA_PATHWAY	TRAF6 CREBBP TNFRSF1B	7.34e-05	15	79	3	M10183
Pathway	REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER	MIB2 JAG1 NOTCH1	7.34e-05	15	79	3	M27202
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	RNF31 BIRC2 MIB2 RBCK1	1.36e-04	47	79	4	MM15179
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	TRAF6 RNF31 BIRC2 MIB2 RBCK1 ARHGEF2	1.43e-04	142	79	6	MM15431
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	TRAF6 RNF31 BIRC2 MIB2 RBCK1 ARHGEF2	2.22e-04	154	79	6	M27697
Pathway	REACTOME_TNF_SIGNALING	RNF31 BIRC2 MIB2 RBCK1	2.69e-04	56	79	4	MM15453
Pathway	PID_NFKAPPAB_CANONICAL_PATHWAY	TRAF6 BIRC2 SSPOP	2.77e-04	23	79	3	M37
Pathway	REACTOME_TNF_SIGNALING	RNF31 BIRC2 MIB2 RBCK1	2.88e-04	57	79	4	M27713
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	MIB2 CREBBP JAG1 NOTCH1	3.08e-04	58	79	4	M29616
Pathway	WP_MARKERS_OF_KIDNEY_CELL_LINEAGE	DCN SALL1 JAG1 NOTCH1	3.29e-04	59	79	4	M46460
Pathway	REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	MIB2 EGF JAG1	3.56e-04	25	79	3	M27879
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_TNF_NFKB_SIGNALING_PATHWAY_LUBAC_MEDIATED_LINEAR_UBIQUITINATION	RNF31 RBCK1	4.58e-04	6	79	2	M47899
Pathway	REACTOME_TRP_CHANNELS	TRPC4 TRPC5 MCOLN3	5.02e-04	28	79	3	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPC4 TRPC5 MCOLN3	5.02e-04	28	79	3	M27241
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD7A MUC5B SSPOP NOTCH1	5.67e-04	68	79	4	M27303
Pathway	REACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT	JAG1 NOTCH1	6.39e-04	7	79	2	M27199
Pathway	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	MIB2 JAG1 NOTCH1	6.80e-04	31	79	3	M592
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MIB2 CREBBP JAG1 NOTCH1	7.81e-04	74	79	4	M616
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	RNF31 BIRC2 RBCK1	8.19e-04	33	79	3	M27438
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	RNF31 BIRC2 RBCK1	8.19e-04	33	79	3	MM15180
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	CREBBP NOTCH1	8.49e-04	8	79	2	M48024
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION	MIB2 JAG1	1.09e-03	9	79	2	M47866
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	TRIM46 TRAF6 RNF31 MIB2 PIAS2 RBCK1 TRIM55 PRKN	3.76e-10	95	101	8	29643511
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	TRIM46 TRAF6 BIRC2 TRIM24 RBCK1 TRIM8 TRIM55	2.54e-08	105	101	7	22493164
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	MDFI PIAS2 NID1 KDM2A OTOG	2.99e-08	31	101	5	31550482
Pubmed	SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.	TRAF6 RNF31 BIRC2 MIB2 RBCK1	2.99e-08	31	101	5	27307491
Pubmed	Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1.	RNF31 BIRC2 RBCK1 PRKN	3.26e-08	12	101	4	29955050
Pubmed	--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.	TRAF6 RNF31 BIRC2 RBCK1	4.69e-08	13	101	4	27810922
Pubmed	HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.	TRAF6 RNF31 BIRC2 RBCK1	4.69e-08	13	101	4	20614026
Pubmed	Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.	SALL3 ISL1 SALL1 JAG1 NOTCH1	6.56e-08	36	101	5	29891551
Pubmed	The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.	RNF31 RBCK1 TNFRSF1B	9.49e-08	4	101	3	29378181
Pubmed	Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).	TRAF6 RNF31 BIRC2	2.37e-07	5	101	3	25494483
Pubmed	Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.	ISL1 JAG1 SLIT1 NOTCH1	2.51e-07	19	101	4	25691540
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	TRIM46 TRAF6 PIAS2 RBCK1 RNF146 TRIM8 TRIM55	2.82e-07	149	101	7	19549727
Pubmed	Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.	TRAF6 RNF31 BIRC2 RBCK1	4.71e-07	22	101	4	36098982
Pubmed	IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.	JAG1 IL17RA NOTCH1	4.72e-07	6	101	3	28561022
Pubmed	The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.	RNF31 RBCK1 PRKN	4.72e-07	6	101	3	23453807
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL6A3 VWF EFEMP2 DCN EFEMP1 HMCN1 NID1	6.11e-07	167	101	7	22159717
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	TRAF6 RNF31 BIRC2 RBCK1	6.81e-07	24	101	4	23524849
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	VWF EFEMP2 MBD1 TSC2 MDFI MDH2 TRIM3 RUSC2 EFEMP1 SLIT1 NOTCH1	7.36e-07	560	101	11	21653829
Pubmed	Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity.	TRAF6 RNF31 PRKN	8.25e-07	7	101	3	27348524
Pubmed	A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.	TRAF6 RNF31 RBCK1	8.25e-07	7	101	3	30913450
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL6A3 VWF DCN SSPOP EFEMP1 HMCN1 NID1	8.36e-07	175	101	7	28071719
Pubmed	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	TRAF6 MDFI TRIM24 CREBBP TRIM8 LTA4H NOTCH1	1.01e-06	180	101	7	24104479
Pubmed	Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.	TRIM46 TRAF6 TRIM3 RBCK1 TRIM8	1.15e-06	63	101	5	23105109
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL6A3 DCN SSPOP HMCN1 NID1	1.24e-06	64	101	5	22261194
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	BIRC2 MIB2 TRIM24 TRIM3 RNF146 HLTF	1.31e-06	118	101	6	19690564
Pubmed	A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.	JAG1 NID1 NOTCH1	1.32e-06	8	101	3	27354375
Pubmed	Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.	VWF JAG1 NOTCH1	1.32e-06	8	101	3	18245384
Pubmed	Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.	TRAF6 RNF31 RBCK1	1.97e-06	9	101	3	28249776
Pubmed	Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.	TRAF6 RNF31 RBCK1	1.97e-06	9	101	3	33815386
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	TRAF6 RNF31 EFEMP2 TSC2 MDFI PIAS2 RBCK1 RASSF5 PRKN	2.76e-06	402	101	9	24722188
Pubmed	Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.	RNF31 TSC2 RBCK1	3.86e-06	11	101	3	31504727
Pubmed	Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.	VWF JAG1 NOTCH1	3.86e-06	11	101	3	15875024
Pubmed	Notch-Tnf signalling is required for development and homeostasis of arterial valves.	JAG1 TNFRSF1B NOTCH1	3.86e-06	11	101	3	26491108
Pubmed	EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.	RNF31 BIRC2 RBCK1	3.86e-06	11	101	3	23732909
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRAF6 VWF CORO2A EFEMP2 MBD1 BIRC2 TSC2 ZNFX1 DCN PIAS2 CREBBP RBCK1 EFEMP1 TRIM8 IFT122	4.56e-06	1285	101	15	35914814
Pubmed	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	TRAF6 RNF31 RBCK1	5.13e-06	12	101	3	19136968
Pubmed	The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.	RNF31 BIRC2 RBCK1	5.13e-06	12	101	3	22607974
Pubmed	Tumour necrosis factor signalling in health and disease.	RNF31 BIRC2 RBCK1	5.13e-06	12	101	3	30755793
Pubmed	Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.	ISL1 JAG1 NOTCH1	5.13e-06	12	101	3	36082581
Pubmed	TSG101 Physically Interacts with Linear Ubiquitin Chain Assembly Complex (LUBAC) and Upregulates the TNFα-Induced NF-κB Activation.	RNF31 BIRC2 RBCK1	6.66e-06	13	101	3	37431163
Pubmed	Direct activation of protein kinases by unanchored polyubiquitin chains.	TRAF6 RNF31 RBCK1	6.66e-06	13	101	3	19675569
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF JAG1 NOTCH1	6.66e-06	13	101	3	20558824
Pubmed	Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.	RNF31 BIRC2 RBCK1	6.66e-06	13	101	3	36268590
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	HK3 MBD1 ISL1 TRIM24 CREBBP TRIM3 SALL1 FBXO42 KDM2A ARHGEF2 OBI1 NOTCH1	7.43e-06	857	101	12	25609649
Pubmed	Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.	EFEMP1 NOTCH1	8.35e-06	2	101	2	22665268
Pubmed	Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.	JAG1 NOTCH1	8.35e-06	2	101	2	23339193
Pubmed	Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13.	EFEMP2 EFEMP1	8.35e-06	2	101	2	10982184
Pubmed	A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.	JAG1 NOTCH1	8.35e-06	2	101	2	23197537
Pubmed	RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31.	RNF31 RBCK1	8.35e-06	2	101	2	35869046
Pubmed	TRPC4 knockdown suppresses epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells.	TRPC4 EGF	8.35e-06	2	101	2	16033767
Pubmed	A new member of the spalt like zinc finger protein family, Msal-3, is expressed in the CNS and sites of epithelial/mesenchymal interaction.	SALL3 SALL1	8.35e-06	2	101	2	11231076
Pubmed	Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo.	JAG1 NOTCH1	8.35e-06	2	101	2	18079963
Pubmed	Jagged1-Notch1 Signaling Pathway Induces M1 Microglia to Disrupt the Barrier Function of Retinal Microvascular Endothelial Cells.	JAG1 NOTCH1	8.35e-06	2	101	2	38783634
Pubmed	E3 ubiquitin-protein ligase 2 inhibits cell proliferation, migration, and invasion of non-small cell lung cancer through ubiquitination of Notch1.	MIB2 NOTCH1	8.35e-06	2	101	2	34971948
Pubmed	A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.	JAG1 NOTCH1	8.35e-06	2	101	2	18660822
Pubmed	Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1.	JAG1 NOTCH1	8.35e-06	2	101	2	25842263
Pubmed	Bronchial Epithelial Cells Promote the Differentiation of Th2 Lymphocytes in Airway Microenvironment through Jagged/Notch-1 Signaling after RSV Infection.	JAG1 NOTCH1	8.35e-06	2	101	2	30943513
Pubmed	Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells.	JAG1 NOTCH1	8.35e-06	2	101	2	22348356
Pubmed	Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.	JAG1 NOTCH1	8.35e-06	2	101	2	22504165
Pubmed	Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.	TRPC4 TRPC5	8.35e-06	2	101	2	22457348
Pubmed	Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells.	JAG1 NOTCH1	8.35e-06	2	101	2	25903338
Pubmed	NOTCH1 and CREBBP co-mutations negatively affect the benefit of adjuvant therapy in completely resected EGFR-mutated NSCLC: translational research of phase III IMPACT study.	CREBBP NOTCH1	8.35e-06	2	101	2	37864465
Pubmed	Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.	JAG1 NOTCH1	8.35e-06	2	101	2	15550486
Pubmed	Conserved gating elements in TRPC4 and TRPC5 channels.	TRPC4 TRPC5	8.35e-06	2	101	2	23677990
Pubmed	Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.	TRPC4 TRPC5	8.35e-06	2	101	2	32033274
Pubmed	Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer.	JAG1 NOTCH1	8.35e-06	2	101	2	20517681
Pubmed	The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.	TRPC4 TRPC5	8.35e-06	2	101	2	17624425
Pubmed	Astrocytes Regulate Angiogenesis Through the Jagged1-Mediated Notch1 Pathway After Status Epilepticus.	JAG1 NOTCH1	8.35e-06	2	101	2	26507745
Pubmed	Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal.	JAG1 NOTCH1	8.35e-06	2	101	2	16163386
Pubmed	Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor.	VWF TNFRSF1B	8.35e-06	2	101	2	19839997
Pubmed	Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma.	JAG1 NOTCH1	8.35e-06	2	101	2	21145176
Pubmed	Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.	TRPC4 TRPC5	8.35e-06	2	101	2	34899056
Pubmed	Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.	TRPC4 TRPC5	8.35e-06	2	101	2	17593972
Pubmed	Studies on sporadic non-syndromic thoracic aortic aneurysms: 1. Deregulation of Jagged/Notch 1 homeostasis and selection of synthetic/secretor phenotype smooth muscle cells.	JAG1 NOTCH1	8.35e-06	2	101	2	29708032
Pubmed	The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells.	JAG1 NOTCH1	8.35e-06	2	101	2	12370358
Pubmed	Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis.	JAG1 NOTCH1	8.35e-06	2	101	2	21220737
Pubmed	JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium.	JAG1 NOTCH1	8.35e-06	2	101	2	27216293
Pubmed	Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation.	JAG1 NOTCH1	8.35e-06	2	101	2	12357247
Pubmed	Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.	JAG1 NOTCH1	8.35e-06	2	101	2	11964309
Pubmed	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.	TRPC4 TRPC5	8.35e-06	2	101	2	26317356
Pubmed	Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells.	JAG1 NOTCH1	8.35e-06	2	101	2	29242532
Pubmed	Endothelial cells provide a notch-dependent pro-tumoral niche for enhancing breast cancer survival, stemness and pro-metastatic properties.	JAG1 NOTCH1	8.35e-06	2	101	2	25380486
Pubmed	Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery.	JAG1 NOTCH1	8.35e-06	2	101	2	21156172
Pubmed	A novel capacitative calcium entry channel expressed in excitable cells.	TRPC4 TRPC5	8.35e-06	2	101	2	9687496
Pubmed	NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling.	JAG1 NOTCH1	8.35e-06	2	101	2	18593716
Pubmed	Demethylation of SFRP2 by histone demethylase KDM2A regulated osteo-/dentinogenic differentiation of stem cells of the apical papilla.	SFRP2 KDM2A	8.35e-06	2	101	2	27074224
Pubmed	Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration; disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling.	JAG1 NOTCH1	8.35e-06	2	101	2	26921446
Pubmed	Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis.	JAG1 NOTCH1	8.35e-06	2	101	2	18192230
Pubmed	Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches.	JAG1 NOTCH1	8.35e-06	2	101	2	28947612
Pubmed	Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP-BCORL1 and KDM2A-WWTR1.	CREBBP KDM2A	8.35e-06	2	101	2	27537276
Pubmed	Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4.	EFEMP2 EFEMP1	8.35e-06	2	101	2	10601734
Pubmed	Epidermal stem cells (ESCs) accelerate diabetic wound healing via the Notch signalling pathway.	JAG1 NOTCH1	8.35e-06	2	101	2	27129289
Pubmed	Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance.	JAG1 NOTCH1	8.35e-06	2	101	2	20800871
Pubmed	Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.	JAG1 NOTCH1	8.35e-06	2	101	2	26646450
Pubmed	[Gene expression of Notch1 and Jagged1 in children with acute leukemia].	JAG1 NOTCH1	8.35e-06	2	101	2	22357466
Pubmed	JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells.	JAG1 NOTCH1	8.35e-06	2	101	2	30231940
Pubmed	A study of the role of Notch1 and JAG1 gene methylation in development of breast cancer.	JAG1 NOTCH1	8.35e-06	2	101	2	26971121
Pubmed	Notch1 signaling and regulatory T cell function.	JAG1 NOTCH1	8.35e-06	2	101	2	18292500
Pubmed	TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.	TRPC4 TRPC5	8.35e-06	2	101	2	30038709
Pubmed	Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.	JAG1 NOTCH1	8.35e-06	2	101	2	26249804
Interaction	UBE2D1 interactions	TRAF6 RNF31 BIRC2 MIB2 TRIM24 CREBBP TRIM3 RBCK1 RNF146 TRIM8 TRIM55 UHRF1 PRKN OBI1	1.82e-10	294	99	14	int:UBE2D1
Interaction	UBE2D2 interactions	TRIM46 TRAF6 RNF31 BIRC2 MIB2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 UHRF1 PRKN OBI1	5.40e-09	318	99	13	int:UBE2D2
Interaction	UBE2D3 interactions	TRAF6 RNF31 BIRC2 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 UHRF1 PRKN	1.32e-06	283	99	10	int:UBE2D3
Interaction	MAP3K7 interactions	TRAF6 RNF31 BIRC2 MIB2 MDH2 RBCK1 FBXO42 TRIM8 PRKN IL17RA TNFRSF1B	2.65e-06	380	99	11	int:MAP3K7
Interaction	TRAF3IP2 interactions	TRAF6 MDFI TRIM55 TNFRSF13C IL17RA	2.70e-06	45	99	5	int:TRAF3IP2
Interaction	UEVLD interactions	TRAF6 BIRC2 RBCK1 PRKN	4.52e-06	23	99	4	int:UEVLD
Interaction	GFI1B interactions	RNF31 EFEMP2 CREBBP EFEMP1 ZNF511 KDM2A NOTCH1	4.85e-06	136	99	7	int:GFI1B
Interaction	TRAF3 interactions	TRAF6 BIRC2 TRIM24 PIAS2 CREBBP TNFRSF13C PRKN IL17RA TNFRSF1B	9.31e-06	278	99	9	int:TRAF3
Interaction	TNFRSF1A interactions	TRAF6 RNF31 TRPC4 TRPC5 BIRC2 RBCK1 RASSF5 TNFRSF1B	9.57e-06	211	99	8	int:TNFRSF1A
Interaction	UBE2L3 interactions	TRAF6 RNF31 BIRC2 MDH2 PIAS2 RBCK1 TRIM55 PRKN	9.57e-06	211	99	8	int:UBE2L3
Interaction	YOD1 interactions	TRAF6 BIRC2 RBCK1 TRIM8 TRIM55	2.43e-05	70	99	5	int:YOD1
Interaction	RBCK1 interactions	TRAF6 RNF31 CREBBP RBCK1 HLTF PRKN TNFRSF1B	2.60e-05	176	99	7	int:RBCK1
Interaction	UBE2D4 interactions	TRAF6 RNF31 TRIM3 RBCK1 TRIM8 PRKN	2.67e-05	119	99	6	int:UBE2D4
Interaction	ATN1 interactions	RNF31 EFEMP2 MDFI SSPOP EFEMP1 SLIT1 KDM2A	3.84e-05	187	99	7	int:ATN1
Interaction	IGFBP4 interactions	HK3 KLHL22 IL17RA NOTCH1	4.83e-05	41	99	4	int:IGFBP4
Interaction	RIPK1 interactions	TRAF6 RNF31 BIRC2 MIB2 RBCK1 PRKN TNFRSF1B	5.52e-05	198	99	7	int:RIPK1
Interaction	ZBP1 interactions	RNF31 BIRC2 MDH2 RBCK1	6.40e-05	44	99	4	int:ZBP1
Interaction	HOXA1 interactions	VWF EFEMP2 MDFI RBCK1 EFEMP1 SLIT1 TRIM8 TRIM55 NOTCH1	6.48e-05	356	99	9	int:HOXA1
Interaction	SMAD3 interactions	RNF31 MBD1 TSC2 ISL1 TRIM24 PIAS2 CREBBP PRKN KDM2A NOTCH1	6.98e-05	447	99	10	int:SMAD3
Interaction	BCL10 interactions	TRAF6 RNF31 BIRC2 MIB2 RBCK1	8.16e-05	90	99	5	int:BCL10
Interaction	PIAS3 interactions	CREBBP RNF146 TRIM8 PRICKLE2 TRIM55	1.06e-04	95	99	5	int:PIAS3
Interaction	SHFL interactions	RNF31 MDFI RBCK1 TRIM55 UHRF1	1.16e-04	97	99	5	int:SHFL
Interaction	CHUK interactions	TRAF6 RNF31 CREBBP RBCK1 PRKN TNFRSF1B TRIM40	1.19e-04	224	99	7	int:CHUK
Interaction	TRAF1 interactions	TRAF6 RNF31 BIRC2 RBCK1 RASSF5 TNFRSF13C PRKN TNFRSF1B	1.25e-04	303	99	8	int:TRAF1
Interaction	LINC02907 interactions	PRKN NOTCH1	1.42e-04	4	99	2	int:LINC02907
Interaction	TLR3 interactions	TRAF6 RNF31 BIRC2 RBCK1	1.44e-04	54	99	4	int:TLR3
Interaction	TEX19 interactions	SALL3 SALL1 TRIM55 WDR44	1.44e-04	54	99	4	int:TEX19
Interaction	NOD2 interactions	TRAF6 RNF31 BIRC2 RBCK1 PRKN	1.69e-04	105	99	5	int:NOD2
Interaction	TRAF2 interactions	TRAF6 RNF31 BIRC2 PIAS2 RBCK1 RASSF5 EFEMP1 RNF146 TNFRSF13C PRKN TNFRSF1B	1.83e-04	603	99	11	int:TRAF2
Interaction	MUS81 interactions	TRAF6 MDFI TRIM24 CREBBP UHRF1	2.02e-04	109	99	5	int:MUS81
Interaction	ATXN7 interactions	VWF RNF31 EFEMP2 EFEMP1 PRKN	2.02e-04	109	99	5	int:ATXN7
Interaction	JAG2 interactions	MBD1 MIB2 JAG1 BRICD5 NOTCH1	2.10e-04	110	99	5	int:JAG2
GeneFamily	Ring finger proteins	TRIM46 TRAF6 RNF31 TRIM75 BIRC2 TRIM24 TRIM3 RBCK1 RNF146 TRIM8 TRIM55 HLTF UHRF1 TRIM40 OBI1	8.32e-13	275	79	15	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM46 TRIM75 TRIM24 TRIM3 TRIM8 TRIM55 TRIM40	1.88e-07	95	79	7	59
GeneFamily	Fibulins	EFEMP2 EFEMP1 HMCN1	4.43e-06	8	79	3	556
GeneFamily	Transient receptor potential cation channels	TRPC4 TRPC5 MCOLN3	2.43e-04	28	79	3	249
GeneFamily	Zinc fingers CXXC-type	MBD1 KDM2A	1.21e-03	12	79	2	136
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	MIB2 CREBBP	2.76e-03	18	79	2	91
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RNF31 RBCK1	3.75e-03	21	79	2	89
GeneFamily	CD molecules\|Tumor necrosis factor receptor superfamily\|Death inducing signaling complex	TNFRSF13C TNFRSF1B	7.09e-03	29	79	2	782
GeneFamily	PHD finger proteins	TRIM24 UHRF1 KDM2A	7.18e-03	90	79	3	88
Coexpression	NABA_CORE_MATRISOME	COL6A3 VWF EFEMP2 DCN SSPOP EFEMP1 HMCN1 SLIT1 NID1 OTOG	9.60e-08	270	101	10	MM17057
Coexpression	NABA_CORE_MATRISOME	COL6A3 VWF EFEMP2 DCN SSPOP EFEMP1 HMCN1 SLIT1 NID1 OTOG	1.14e-07	275	101	10	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	VWF EFEMP2 SSPOP EFEMP1 HMCN1 SLIT1 NID1 OTOG	7.78e-07	191	101	8	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	VWF EFEMP2 SSPOP EFEMP1 HMCN1 SLIT1 NID1 OTOG	9.45e-07	196	101	8	M3008
Coexpression	GSE34179_THPOK_KO_VS_WT_VA14I_NKTCELL_DN	VWF NDUFS3 EFEMP1 ACKR3 TNFRSF13C UHRF1 NID1	1.23e-05	199	101	7	M9398
Coexpression	GSE3982_EOSINOPHIL_VS_BCELL_UP	HK3 DSC3 GRIK5 JAG1 TNFRSF1B MCOLN3 NOTCH1	1.23e-05	199	101	7	M5406
Coexpression	LIU_PROSTATE_CANCER_DN	SALL3 DSC3 TRPC4 EFEMP2 FCGBP EFEMP1 CELSR2 ACKR3 PRICKLE2 NID1	2.11e-05	493	101	10	M19391
Coexpression	NABA_MATRISOME	COL6A3 SFRP2 VWF EFEMP2 ADAM29 MUC5B DCN SSPOP EFEMP1 EGF HMCN1 SLIT1 NID1 OTOG	3.22e-05	1008	101	14	MM17056
Coexpression	NABA_MATRISOME	COL6A3 SFRP2 VWF EFEMP2 ADAM29 MUC5B DCN SSPOP EFEMP1 EGF HMCN1 SLIT1 NID1 OTOG	3.91e-05	1026	101	14	M5889
Coexpression	DESCARTES_FETAL_STOMACH_STROMAL_CELLS	COL6A3 SFRP2 MDFI DCN	4.17e-05	50	101	4	M40304
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL3	SFRP2 THSD7A DSC3 EFEMP2 HEATR5A DCN SSPOP EFEMP1 SALL1 SLIT1	7.56e-05	574	101	10	M39056
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_1000	SALL3 THSD7A DSC3 ISL1 PIAS2 SALL1 HMCN1 ACKR3 JAG1 SOCS4	8.03e-06	377	96	10	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k2
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#3_top-relative-expression-ranked_200	COL6A3 SFRP2 EFEMP1 HMCN1	4.64e-05	44	96	4	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k3_200
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_200	COL6A3 SFRP2 ISL1 DCN EFEMP1 HMCN1	5.52e-05	147	96	6	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_200
CoexpressionAtlas	Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4	COL6A3 SFRP2 DCN EFEMP1 NID1	7.89e-05	97	96	5	GSM777046_100
CoexpressionAtlas	dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_500	COL6A3 SFRP2 EFEMP2 EFEMP1 HMCN1 ACKR3	7.95e-05	157	96	6	gudmap_dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k4_500
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 DSC3 EFEMP2 MDFI DCN EFEMP1	1.57e-07	176	101	7	135d51d28a7ad2a67d5a6c49eb6e661f4beb66f5
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 DSC3 EFEMP2 MDFI DCN EFEMP1	1.57e-07	176	101	7	2287bd8382f41e36ebb0875a0133bada1ec81fa7
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.55e-07	189	101	7	bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.64e-07	190	101	7	f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.64e-07	190	101	7	c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.64e-07	190	101	7	47077579496c5340e99f61499427a3a36b566da3
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.73e-07	191	101	7	a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	2.73e-07	191	101	7	19c67a812b8ce97472d316acd15aeefe8736000d
ToppCell	facs-SCAT-Fat-3m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	3.04e-07	194	101	7	14b614f039bc866a1348a2728a68b7d254c7748c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	3.04e-07	194	101	7	68c7bfead1158641928cc276f599b4a79e06c73c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	3.04e-07	194	101	7	f6aeae6a1e4017e341323fd4784c9e3bae00552b
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	3.25e-07	196	101	7	c373465e34e2dd581247962d59e0477aae877079
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	3.25e-07	196	101	7	8b5337ccf74de90e8b89a02ac00671af1de2cfff
ToppCell	COPD-Stromal\|COPD / Disease state, Lineage and Cell class	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 PRICKLE2 NID1	3.37e-07	197	101	7	d5390d86acaa8c39f1da893e8d2271f9ed2951d7
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 SFRP2 DSC3 DCN JAG1 FSHR PLA2G5	3.37e-07	197	101	7	7c275a2ac24a9a4f83fceda93a067e754837102f
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 THSD7A MDFI DCN EFEMP1 ACKR3 NID1	3.37e-07	197	101	7	ad6c200a193a15360d17463e18a465ce1b90b8da
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 EFEMP2 MDFI DCN HMCN1 PLA2G5 MCOLN3	3.49e-07	198	101	7	a9afedbc0556faf4a46f7bf28f4a9adb3bc859d8
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 EFEMP2 MDFI DCN EFEMP1 SALL1 NID1	3.49e-07	198	101	7	75d104eead681f6bf47c4dd24913cc768c9a1717
ToppCell	IPF-Stromal\|IPF / Disease state, Lineage and Cell class	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 HMCN1 NID1	3.49e-07	198	101	7	ece914c32c9b123b779aa9624b92e6230763a20e
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 EFEMP2 MDFI DCN HMCN1 PLA2G5 MCOLN3	3.49e-07	198	101	7	7b5350768f306ec528e271d2ac4470bf668ec6f0
ToppCell	metastatic_Brain-Fibroblasts-FB-like_cells\|metastatic_Brain / Location, Cell class and cell subclass	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 PLA2G5 NID1	3.61e-07	199	101	7	12133087eae9f0e9b6c13a71e8187117768e64ce
ToppCell	(5)_Fibroblast-G\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL6A3 MDFI DCN EFEMP1 HMCN1 SLIT1 MCOLN3	3.61e-07	199	101	7	b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell	(5)_Fibroblast-D\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 SLIT1 PLA2G5	3.61e-07	199	101	7	3f415620ad8b8d8c6871e1353e13f87b281fcc0e
ToppCell	Biopsy_IPF-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 PLA2G5 NID1	3.73e-07	200	101	7	2c5626ea8fb4b702d4560117e53edf6cfcf1971e
ToppCell	distal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A3 TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	3.73e-07	200	101	7	911db29f254bb697610e720ba78816e2c7f57933
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	3.73e-07	200	101	7	3e6730c9ed7003a4acf501f699a4965a7a50f946
ToppCell	(6)_Stroma\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 SLIT1 NID1	3.73e-07	200	101	7	f9baef67dde62f1c161a9408a78f635ea70ea9d3
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 ACKR3 NID1	3.73e-07	200	101	7	14f3fe19b6647b32a5e28d717235741997d8522c
ToppCell	(6)_Stroma\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 SLIT1 NID1	3.73e-07	200	101	7	f0818821c495022569aef2c1886d9f2446dc027e
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 SFRP2 DCN EFEMP1 HMCN1 PLA2G5 NID1	3.73e-07	200	101	7	44317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_adventitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 PLA2G5 NID1	3.73e-07	200	101	7	9dd2eb70c1cc146935f5aff27373dfc65cb8c098
ToppCell	cellseq2-Mesenchymal-Fibroblastic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 SFRP2 DCN EFEMP1 HMCN1 PLA2G5 NID1	3.73e-07	200	101	7	1c10597edd532bf172ca09870a937d35e2585081
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 SFRP2 DCN EFEMP1 HMCN1 PLA2G5 NID1	3.73e-07	200	101	7	440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 EFEMP2 ADAM29 DCN EFEMP1	1.41e-06	154	101	6	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 EFEMP2 ADAM29 DCN EFEMP1	1.41e-06	154	101	6	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SFRP2 THSD7A DSC3 DCN TNNI3K ACKR3	1.77e-06	160	101	6	dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFRP2 ISL1 DCN EFEMP1 CHST4 PRKN	2.26e-06	167	101	6	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFRP2 ISL1 DCN EFEMP1 CHST4 PRKN	2.26e-06	167	101	6	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TRPC4 DCN UHRF1 NID1 PEAR1	2.42e-06	169	101	6	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 DCN TNNI3K ACKR3 NID1	2.68e-06	172	101	6	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFRP2 DSC3 ISL1 DCN EFEMP1 CHST4	2.78e-06	173	101	6	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Myofibroblast\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL6A3 MDFI DCN PLA2G5 NID1 PEAR1	3.27e-06	178	101	6	1802ff1c6cb18ee62cfef7270c0971048fae5315
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Myofibroblast-VLMC_L1-3_CYP1B1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL6A3 MDFI DCN PLA2G5 NID1 PEAR1	3.27e-06	178	101	6	4368d20130e5a08716564c19470b6014f16902ac
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 DCN HMCN1 PRICKLE2 NID1 MCOLN3	3.72e-06	182	101	6	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	COL6A3 VWF EGF NID1 TRIM40 PEAR1	3.96e-06	184	101	6	10607d7d92edcbb92d992900086b90b307421cc3
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DCN RUSC2 EFEMP1 ACKR3 PRICKLE2 NID1	4.08e-06	185	101	6	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL6A3 SFRP2 DCN EFEMP1 PLA2G5 NID1	4.08e-06	185	101	6	506eee2c1b6e8acec3aa8b2c66868010006c4c14
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	4.08e-06	185	101	6	01bbe1e09f9ccae837a03ea2cdd168fa10800942
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 EFEMP2 DCN JAG1 PEAR1	4.21e-06	186	101	6	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 SFRP2 EFEMP2 DCN JAG1 PEAR1	4.21e-06	186	101	6	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 DCN EFEMP1 ACKR3 PLA2G5	4.21e-06	186	101	6	07d94d5d1c2fe7bb909a07ca81058a0eabc65c60
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 EFEMP2 ISL1 DCN EFEMP1 NID1	4.34e-06	187	101	6	6f47a80e612b320f571210483e62ff5db2a8ea43
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	4.48e-06	188	101	6	e54e09d34e263d5709c337914809e61e74e20591
ToppCell	droplet-Fat-Scat-21m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	4.48e-06	188	101	6	7fc9810ab14354cb512e2b1285562009c10203f5
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	4.48e-06	188	101	6	e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	4.62e-06	189	101	6	d531399749409d614adca13d181830c6e3287508
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SFRP2 TRPC4 DCN NID1 MCOLN3	4.91e-06	191	101	6	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	VWF THSD7A HMCN1 ACKR3 JAG1 NOTCH1	4.91e-06	191	101	6	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL6A3 TRPC4 EFEMP1 JAG1 PLA2G5 PEAR1	4.91e-06	191	101	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	4.91e-06	191	101	6	1b26056df078674f37a6c06f6256b30cfcec21a7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SFRP2 TRPC4 DCN NID1 MCOLN3	4.91e-06	191	101	6	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SFRP2 TRPC4 DCN NID1 MCOLN3	5.06e-06	192	101	6	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFEMP2 MDFI DCN EFEMP1 PRICKLE2 NID1	5.06e-06	192	101	6	9479e9859140ba98abfe88414de0b28fc2bf43b7
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.06e-06	192	101	6	fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.06e-06	192	101	6	7a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 SFRP2 TRPC4 DCN NID1 MCOLN3	5.06e-06	192	101	6	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	facs-Trachea-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.06e-06	192	101	6	e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.21e-06	193	101	6	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.21e-06	193	101	6	b2abe939027a69b60d83a28d4d4cc53ba1dee4c5
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.21e-06	193	101	6	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.21e-06	193	101	6	87ce81ff5b27d9c4300826d76ff5a62e9c408d5d
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.21e-06	193	101	6	d75f334fe3d9f39ef02a5de0f8202f7a761a8fc8
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.21e-06	193	101	6	41ea268e7697101fe70d8ef1045f3a43b9311739
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.21e-06	193	101	6	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF THSD7A HMCN1 ACKR3 JAG1 NOTCH1	5.21e-06	193	101	6	58c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell	facs-Kidney-nan-18m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.36e-06	194	101	6	bbc625b4cc53bb7d6254fde287258e51f9171572
ToppCell	facs-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.36e-06	194	101	6	fcd5e9238d299c41f0bf9693b56cd8c900d2112b
ToppCell	(5)_Fibroblast-C_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL6A3 EFEMP2 MDFI DCN HMCN1 PLA2G5	5.36e-06	194	101	6	29a72e565c19407bbd198cfbc2a78106fe830d05
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.36e-06	194	101	6	3cffb5c58f6d5bd254f39ee9c41b7e1e4da0ff75
ToppCell	facs-Kidney-nan-18m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.36e-06	194	101	6	6afc21c5fec30ab8e373e3e46ab7866204c805b6
ToppCell	3'-Distal_airway-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPC4 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.36e-06	194	101	6	f5e3e675187afb6efa774f2a8d685efcf813de82
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.52e-06	195	101	6	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 SFRP2 DCN EFEMP1 ACKR3 NID1	5.52e-06	195	101	6	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	COL6A3 DCN EFEMP1 PRICKLE2 PLA2G5 NID1	5.52e-06	195	101	6	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	COL6A3 DCN ACKR3 PRICKLE2 PLA2G5 NID1	5.52e-06	195	101	6	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.52e-06	195	101	6	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.52e-06	195	101	6	9cef6f18664518060af7c192310dddce6d70345a
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 DCN EFEMP1 HMCN1 JAG1 NID1	5.69e-06	196	101	6	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	COL6A3 EFEMP2 DCN EFEMP1 HMCN1 NID1	5.69e-06	196	101	6	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	facs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.69e-06	196	101	6	65f2f51e17f1869f3468813127b96d3048d8ad41
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 DCN EFEMP1 HMCN1 JAG1 NID1	5.69e-06	196	101	6	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 EFEMP2 DCN EFEMP1 NID1 PEAR1	5.69e-06	196	101	6	9d18381d7aaa063094a5df769a04c73350471525
ToppCell	IPF-Stromal-Fibroblast\|IPF / Disease state, Lineage and Cell class	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.69e-06	196	101	6	f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCell	facs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.69e-06	196	101	6	e4ed897900a6472738bc6be2fb4817192727225d
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	COL6A3 SFRP2 EFEMP2 MDFI DCN HMCN1	5.69e-06	196	101	6	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 TRPC4 DCN SALL1 PRICKLE2 NID1	5.69e-06	196	101	6	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	facs-SCAT-Fat-18m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 EFEMP2 DCN EFEMP1 ACKR3 NID1	5.69e-06	196	101	6	2cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCell	Control-Stromal-Fibroblast\|Control / Disease state, Lineage and Cell class	COL6A3 SFRP2 EFEMP2 DCN EFEMP1 NID1	5.69e-06	196	101	6	7ca94477498a84cafcdd9933ee92a6cbde76c70e
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ISL1 MDFI SALL1 HMCN1 NOTCH1	5.69e-06	196	101	6	e386526332138e636aef2542c11316347a45689c
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFEMP2 ASPHD2 DCN EFEMP1 ACKR3 NID1	5.69e-06	196	101	6	ed6047b48b6a96baa6a90c7af784e7c34b32824d
Disease	POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCY	RNF31 RBCK1	1.00e-05	2	94	2	C4014605
Disease	congenital heart disease (is_implicated_in)	ISL1 JAG1 NOTCH1	6.04e-05	24	94	3	DOID:1682 (is_implicated_in)
Disease	response to peginterferon alfa-2a	VWF CORO2A PRKN	6.84e-05	25	94	3	EFO_0010103
Disease	Glioblastoma	EGF JAG1 PRKN NOTCH1	1.21e-04	79	94	4	C0017636
Disease	laryngeal carcinoma (is_marker_for)	TRAF6 ACKR3	1.49e-04	6	94	2	DOID:2600 (is_marker_for)
Disease	Giant Cell Glioblastoma	EGF JAG1 PRKN NOTCH1	1.53e-04	84	94	4	C0334588
Disease	response to anticonvulsant	TDRD15 COL6A3 THSD7A NID1	1.61e-04	85	94	4	GO_0036277
Disease	endometrial cancer (is_marker_for)	EFEMP2 TNFRSF1B NOTCH1	1.90e-04	35	94	3	DOID:1380 (is_marker_for)
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 CELSR2	2.78e-04	8	94	2	EFO_0008589, EFO_0008595
Disease	Mammary Carcinoma, Human	SFRP2 DSC3 BIRC2 NDUFS3 EFEMP1 EGF JAG1 NOTCH1	2.78e-04	525	94	8	C4704874
Disease	Mammary Neoplasms, Human	SFRP2 DSC3 BIRC2 NDUFS3 EFEMP1 EGF JAG1 NOTCH1	2.78e-04	525	94	8	C1257931
Disease	Kidney Neoplasm	TSC2 RASSF5 HLTF	2.84e-04	40	94	3	C0022665
Disease	Mammary Neoplasms	SFRP2 DSC3 BIRC2 NDUFS3 EFEMP1 EGF JAG1 NOTCH1	2.85e-04	527	94	8	C1458155
Disease	Adenoid Cystic Carcinoma	CREBBP JAG1 UHRF1 NOTCH1	3.00e-04	100	94	4	C0010606
Disease	Breast Carcinoma	SFRP2 DSC3 BIRC2 NDUFS3 EFEMP1 EGF JAG1 NOTCH1	3.27e-04	538	94	8	C0678222
Disease	Adult Hepatocellular Carcinoma	TSC2 EGF	3.56e-04	9	94	2	C0279607
Disease	Malignant neoplasm of kidney	TSC2 RASSF5 HLTF	4.03e-04	45	94	3	C0740457
Disease	Colorectal Carcinoma	SFRP2 SALL3 HK3 ADAM29 TNNI3K EFEMP1 ACKR3 NID1 KDM2A	4.08e-04	702	94	9	C0009402
Disease	Condition, Preneoplastic	TSC2 EGF SOCS4 PRICKLE2	4.31e-04	110	94	4	C0282313
Disease	Precancerous Conditions	TSC2 EGF SOCS4 PRICKLE2	4.31e-04	110	94	4	C0032927
Disease	Glioblastoma Multiforme	EGF JAG1 PRKN NOTCH1	4.46e-04	111	94	4	C1621958
Disease	Congenital Abnormality	SALL1 NOTCH1	5.42e-04	11	94	2	C0000768
Disease	pulmonary fibrosis (biomarker_via_orthology)	VWF JAG1 NOTCH1	5.51e-04	50	94	3	DOID:3770 (biomarker_via_orthology)
Disease	Malignant neoplasm of breast	SFRP2 VWF HK3 DSC3 TRPC4 BIRC2 NDUFS3 EFEMP1 EGF JAG1 NOTCH1	6.18e-04	1074	94	11	C0006142
Disease	Squamous cell carcinoma of the head and neck	TSC2 TNNI3K NOTCH1	6.18e-04	52	94	3	C1168401
Disease	nicotine dependence (implicated_via_orthology)	TRPC4 TRPC5	6.49e-04	12	94	2	DOID:0050742 (implicated_via_orthology)
Disease	Familial thoracic aortic aneurysm and aortic dissection	EFEMP2 JAG1 NOTCH1	6.53e-04	53	94	3	C4707243
Disease	kynurenic acid measurement	THSD7A PIGX	7.65e-04	13	94	2	EFO_0010506
Disease	3-carboxy-4-methyl-5-propyl-2-furanpropanoate CMPF measurement	GRIK5 SLC17A1	7.65e-04	13	94	2	EFO_0021053
Disease	atrial fibrillation (is_implicated_in)	VWF ISL1	8.91e-04	14	94	2	DOID:0060224 (is_implicated_in)
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 CELSR2	8.91e-04	14	94	2	EFO_0004611, EFO_0008589
Disease	pancreatic ductal carcinoma (is_marker_for)	TSC2 MUC5B EGF	9.86e-04	61	94	3	DOID:3587 (is_marker_for)
Disease	response to statin, LDL cholesterol change measurement	TDRD15 CELSR2	1.03e-03	15	94	2	EFO_0007804, GO_0036273
Disease	Eye Abnormalities	JAG1 IFT122	1.32e-03	17	94	2	C0015393
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 CELSR2	1.32e-03	17	94	2	EFO_0022232
Disease	acute kidney failure (is_marker_for)	EGF TNFRSF1B	1.32e-03	17	94	2	DOID:3021 (is_marker_for)
Disease	ovarian cancer (is_marker_for)	EFEMP2 EGF TNFRSF1B	1.35e-03	68	94	3	DOID:2394 (is_marker_for)
Disease	Alzheimer's disease (is_marker_for)	TSC2 NDUFS3 EGF PRKN TNFRSF1B	1.41e-03	257	94	5	DOID:10652 (is_marker_for)
Disease	autism spectrum disorder (implicated_via_orthology)	TRPC4 TRPC5 TSC2 CREBBP	1.44e-03	152	94	4	DOID:0060041 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	TDRD15 CELSR2	1.49e-03	18	94	2	EFO_0008317, EFO_0008589
Disease	Autistic Disorder	FBXO40 TSC2 EGF PRKN TNFRSF1B	1.51e-03	261	94	5	C0004352
Disease	pulse pressure measurement	TDRD15 COL6A3 WDR7 MBD1 HEATR5A SSPOP EFEMP1 JAG1 SLIT1 TRIM8 UHRF1 OBI1	1.55e-03	1392	94	12	EFO_0005763
Disease	myocardial infarction (biomarker_via_orthology)	SFRP2 VWF DCN TNFRSF1B	1.74e-03	160	94	4	DOID:5844 (biomarker_via_orthology)
Disease	lung non-small cell carcinoma (is_marker_for)	BIRC2 RASSF5 EGF KDM2A	2.12e-03	169	94	4	DOID:3908 (is_marker_for)
Disease	Renal glomerular disease	CREBBP SALL1	2.43e-03	23	94	2	C0268731
Disease	Glomerulopathy Assessment	CREBBP SALL1	2.43e-03	23	94	2	C4521256
Disease	liver fibrosis measurement	TDRD15 VWF CELSR2	2.65e-03	86	94	3	EFO_0010576
Disease	Carcinoma, Pancreatic Ductal	JAG1 NOTCH1	2.65e-03	24	94	2	C0887833
Disease	Kidney Diseases	EGF ACKR3 IFT122	2.82e-03	88	94	3	C0022658
Disease	severe acute respiratory syndrome, COVID-19	XCR1 COL6A3 THSD7A RASSF5 PRICKLE2 PLA2G5	3.10e-03	447	94	6	EFO_0000694, MONDO_0100096
Disease	obsessive-compulsive disorder, Tourette syndrome	WDR7 TRPC4	3.10e-03	26	94	2	EFO_0004242, EFO_0004895
Disease	response to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema	THSD7A KDM2A	3.10e-03	26	94	2	EFO_0005325, EFO_0005532, EFO_0010735

Protein segments in the cluster

Peptide	Gene	Start	Entry
NHDEDTCRCSQPRCI	ADAM29	341	Q9UKF5
VRSHTGERPFQCCQC	CTCFL	361	Q8NI51
QSGCICYRPEEHQVC	BRICD5	111	Q6PL45
CVEACNLIACARHQQ	CHRNG	441	P07510
LICPTCNVTIHNRCK	ARHGEF2	66	Q92974
SIQRCIQSLVHACQC	CREBBP	1771	Q92793
VCDLNPCEHQSVCTR	CELSR2	1831	Q9HCU4
CCLPVCAVNFKCLHE	ALG1L	81	Q6GMV1
CSNPQRAQLCEDHCV	MUC5B	346	Q9HC84
CCRAVVSCTPVHLVD	RAB40B	196	Q12829
FTCHPECRSLIQLDC	RASSF5	156	Q8WWW0
EIIPCHRCVLAACSD	KBTBD3	61	Q8NAB2
CQAIHCRAILPCQDT	LTA4H	136	P09960
CHPACRVGQCVVVFS	FBXO42	341	Q6P3S6
CCRHQVQIQPFFSSC	IL17RA	276	Q96F46
ASHCIVVLCFFVPCV	OR10G4	241	Q8NGN3
PSVCCIQETHLTCRD	nan	36	O00370
CEVDINECVLSPCRH	NOTCH1	866	P46531
CNLLVVCANHIILCQ	IFT122	436	Q9HBG6
QAALPNVIRFCCCAA	MCOLN3	406	Q8TDD5
VNCALCHRALPVFEQ	HECA	396	Q9UBI9
VNEFTCPVCFHVNCL	RBCK1	386	Q9BYM8
AACAQHCPEAMICVI	MDH2	126	P40926
CQTQEDCGHCPICLR	MBD1	231	Q9UIS9
CVPLCAQECVHGRCV	PEAR1	101	Q5VY43
AQECVHGRCVAPNQC	PEAR1	106	Q5VY43
FRCQCHLRVVQCSDL	DCN	56	P07585
ICNNHPGTFRCECVE	NID1	726	P14543
RQPVICINNHVFCSI	OBI1	26	Q5W0B1
HVCAAVCTRAAQLCA	HK3	386	P52790
RVLCCLPCKVEFDNH	LRRC8B	51	Q6P9F7
CQESSPCHQRCFNAI	HMCN1	5196	Q96RW7
PFCHVNLCACDRKLV	PLA2G5	101	P39877
HPPCFVCTVCNELLV	PRICKLE2	156	Q7Z3G6
VYCQSPECVRCTHNE	ASPHD2	106	Q6ICH7
VFAAECVCRIINQCE	HEATR5A	1221	Q86XA9
ECCICNEIVHPGCLQ	KDM2A	641	Q9Y2K7
AACQLQIPEIIHFCC	KLHL22	126	Q53GT1
VNLCECTHPTQCRAT	DSC3	666	Q14574
CPRNVSECSHDCVLT	EGF	401	P01133
VLIDNCRQQCTCHVG	FCGBP	2801	Q9Y6R7
VLTCHVCLDICNIDP	COL6A3	2581	P12111
CAVNPHFIAVVTECA	CORO2A	41	Q92828
QCLSLVHCCVNPVLY	ACKR3	301	P25106
VLVGCCVLITCRQHN	BRF2	116	Q9HAW0
PLQAQEDCCVHCILS	MDFI	156	Q99750
LAKHLQVCPASVVCC	FBXO40	81	Q9UH90
AHVFCKPCICQVIQN	HLTF	776	Q14527
RICHCSNRVFLCQES	FSHR	21	P23945
PCTHVRVCQECRRIQ	GRIK5	926	Q16478
HCRDVNECLTIPEAC	EFEMP2	51	O95967
NECIICHRVLSCQSA	SALL1	706	Q9NSC2
TDPNQCVICHRVLSC	SALL3	676	Q9BXA9
CAEPCSRVTVCHLQA	DSCR10	66	P59022
ASHCIVVLCFFVPCV	OR10G9	241	Q8NGN4
PCRAVTCTHLQCFDA	PIAS2	356	O75928
HCQNEINRFQCLCPT	JAG1	501	P78504
CPICIDSHIRLVFQC	MIB2	911	Q96AX9
TCVPIAEQDCVRHIC	OTOG	2051	Q6ZRI0
VHRNTTELCCPLYQC	OTOG	2596	Q6ZRI0
QPERCAVFQCAQCHA	OIP5	71	O43482
DECTIPPYCHQRCVN	EFEMP1	216	Q12805
HIPLVHCQVPDRQCC	RUSC2	16	Q8N2Y8
CFISIDRHCAICDPL	TAAR5	126	O14804
IQPCHSLCVQVKDRC	SFRP2	111	Q96HF1
CPNHQKRVCRFCEES	TRIM40	71	Q6P9F5
LPCTHNVCQACAREV	TRIM46	46	Q7Z4K8
IENCIEKLPTFHFCC	SLFN14	271	P0C7P3
HCVSPEQLCDGVRQC	SSPOP	1616	A2VEC9
TFQHRLACVQECPCV	SSPOP	3741	A2VEC9
NCTCVNESLVCPHQE	SSPOP	4751	A2VEC9
SPVLVFQCNSRHVIC	PRKN	246	O60260
ACLIPCQQDCIVSEF	THSD7A	186	Q9UPZ6
FRCCLNHFIEPVSCK	TDRD15	861	B5MCY1
VQVSCFNELEVCIHP	NDUFS3	76	O75489
VHCCNVIITAQRACL	SLC17A1	26	Q14916
PFSLQHICRTVICNC	SOCS4	386	Q8WXH5
ECAICLQTCVHPVSL	RNF146	36	Q9NTX7
HPECFRCDLCQEVLA	LIMS1	91	P48059
HIECFRCVACSRQLI	ISL1	101	P61371
CCLQHQELFPCSFVI	SWT1	491	Q5T5J6
VVFIPCGHLVVCQEC	BIRC2	581	Q13490
CGHLVVCQECAPSLR	BIRC2	586	Q13490
HCRLLCSQQPFEVVE	CHST4	151	Q8NCG5
EQLEATCPQCHQTFC	RNF31	811	Q96EP0
RVPAFACQVAGCCQV	ZNF511	76	Q8NB15
ICRNLAFSHCCFNPV	XCR1	271	P46094
RCPVCSQECAERHII	TRIM24	126	O15164
PCQHNLCRKCASDIF	TRIM55	41	Q9BYV6
SQCIDCFQAFLPVHC	PIGX	136	Q8TBF5
HCDVVNLTCEACQEP	VWF	1226	P04275
GHVQPIRCTNCVRCV	RPS26P11	16	Q5JNZ5
VQTPCGHRFCKACII	TRAF6	81	Q9Y4K3
PVTIECGHNFCRSCI	TRIM75	26	A6NK02
DLQELFPCPVCRHQC	TRIM75	46	A6NK02
SRRECLCCFQHIDFV	WDR44	636	Q5JSH3
ICQEGHRCPLVCFQE	ZNFX1	1326	Q9P2E3
HRCPLVCFQECQPCQ	ZNFX1	1331	Q9P2E3
TFQCICCQELVFRPI	UHRF1	721	Q96T88
CCCECSLVQLQRVHP	ZNF416	251	Q9BWM5
TDICRPHQICNVVAI	TNFRSF1B	176	P20333
PHQIRCNCVECVSSS	TRPC5	171	Q9UL62
VVCPHKCRCEANVVE	SLIT1	511	O75093
VCLRCEAPCCQSHVQ	TRIM8	106	Q9BZR9
FCREVSILCQLNHPC	TNNI3K	506	Q59H18
PAECFDLLVRHCVAC	TNFRSF13C	21	Q96RJ3
PPENCSARVQHCICS	WDR7	521	Q9Y4E6
PHEVRCNCVECVSSS	TRPC4	171	Q9UBN4
CLEQGLIHRCASQCV	TSC2	791	P49815
PCLHTFCERCLQNYI	TRIM3	36	O75382