Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-L-arabinofuranosidase activity

OTOGL OTOG

1.50e-062252GO:0046556
GeneOntologyMolecularFunctionpalmitoyl-(protein) hydrolase activity

ABHD17A ABHD17B

1.16e-0413252GO:0008474
GeneOntologyMolecularFunctionpalmitoyl hydrolase activity

ABHD17A ABHD17B

1.36e-0414252GO:0098599
GeneOntologyMolecularFunctionthiolester hydrolase activity

ABHD17A ABHD17B

1.57e-0347252GO:0016790
GeneOntologyBiologicalProcessarabinose metabolic process

OTOGL OTOG

1.41e-062252GO:0019566
GeneOntologyBiologicalProcessvibrational conductance of sound to the inner ear

OTOGL OTOG

1.41e-062252GO:0055127
GeneOntologyBiologicalProcessL-arabinose metabolic process

OTOGL OTOG

1.41e-062252GO:0046373
GeneOntologyBiologicalProcessnegative regulation of protein localization to microtubule

ABHD17A ABHD17B

1.41e-055252GO:1902817
GeneOntologyBiologicalProcessregulation of protein localization to microtubule

ABHD17A ABHD17B

1.41e-055252GO:1902816
GeneOntologyBiologicalProcessNLRP3 inflammasome complex assembly

USP50 ABHD17A NLRP3

2.31e-0546253GO:0044546
GeneOntologyBiologicalProcesscanonical inflammasome complex assembly

USP50 ABHD17A NLRP3

2.62e-0548253GO:0140632
GeneOntologyBiologicalProcessinflammasome-mediated signaling pathway

USP50 ABHD17A NLRP3

3.54e-0553253GO:0141084
GeneOntologyBiologicalProcessprotein depalmitoylation

ABHD17A ABHD17B

6.31e-0510252GO:0002084
GeneOntologyBiologicalProcesspentose metabolic process

OTOGL OTOG

1.09e-0413252GO:0019321
GeneOntologyBiologicalProcessregulation of response to external stimulus

USP50 NLRP11 ADAMTS18 ABHD17A NLRC5 MEGF8 MYCBP2 NLRP3

1.09e-041316258GO:0032101
GeneOntologyBiologicalProcessmacromolecule depalmitoylation

ABHD17A ABHD17B

1.27e-0414252GO:0098734
GeneOntologyBiologicalProcesspositive regulation of protein localization to endosome

ABHD17A ABHD17B

1.27e-0414252GO:1905668
GeneOntologyBiologicalProcessregulation of protein localization to endosome

ABHD17A ABHD17B

1.47e-0415252GO:1905666
GeneOntologyBiologicalProcessinterleukin-18 production

USP50 NLRP3

1.90e-0417252GO:0032621
GeneOntologyBiologicalProcesslipoprotein catabolic process

ABHD17A ABHD17B

1.90e-0417252GO:0042159
GeneOntologyBiologicalProcessprotein localization to microtubule

ABHD17A ABHD17B

2.64e-0420252GO:0035372
GeneOntologyBiologicalProcesslipoprotein metabolic process

APOL3 ABHD17A ABHD17B

7.27e-04147253GO:0042157
GeneOntologyBiologicalProcessprotein localization to endosome

ABHD17A ABHD17B

7.28e-0433252GO:0036010
GeneOntologyBiologicalProcessregulation of NLRP3 inflammasome complex assembly

USP50 ABHD17A

1.24e-0343252GO:1900225
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

USP50 ABHD17A NLRP3

1.48e-03188253GO:0002753
GeneOntologyBiologicalProcesspositive regulation of innate immune response

USP50 ABHD17A NLRC5 NLRP3

1.53e-03420254GO:0045089
GeneOntologyBiologicalProcessregulation of inflammasome-mediated signaling pathway

USP50 ABHD17A

1.54e-0348252GO:0141085
GeneOntologyBiologicalProcesssensory organ development

ADAMTS18 BNC2 SPRY1 OTOGL OTOG

1.61e-03730255GO:0007423
GeneOntologyBiologicalProcesspositive regulation of response to external stimulus

USP50 ABHD17A NLRC5 MEGF8 NLRP3

1.69e-03738255GO:0032103
GeneOntologyCellularComponentpostsynaptic recycling endosome membrane

ABHD17A ABHD17B

2.05e-056252GO:0098944
GeneOntologyCellularComponentpostsynaptic endosome membrane

ABHD17A ABHD17B

7.50e-0511252GO:0098895
GeneOntologyCellularComponentpostsynaptic recycling endosome

ABHD17A ABHD17B

1.06e-0413252GO:0098837
GeneOntologyCellularComponentdendritic spine

USP50 ABHD17A ABHD17B TENM2

1.83e-04242254GO:0043197
GeneOntologyCellularComponentneuron spine

USP50 ABHD17A ABHD17B TENM2

1.98e-04247254GO:0044309
GeneOntologyCellularComponentpostsynaptic endosome

ABHD17A ABHD17B

4.38e-0426252GO:0098845
GeneOntologyCellularComponentpostsynaptic membrane

ABHD17A ABHD17B PCDH10 TENM2

1.27e-03405254GO:0045211
MousePhenoabnormal lateral geniculate nucleus morphology

MYCBP2 TENM2

5.42e-058202MP:0004165
DomainNACHT

NLRP11 NLRC5 NLRP3

2.84e-0623233PS50837
DomainNACHT_NTPase

NLRP11 NLRC5 NLRP3

2.84e-0623233IPR007111
DomainLRR_6

NLRP11 NLRC5 NLRP3

4.10e-0555233PF13516
DomainHydrolase_4

ABHD17A ABHD17B

5.19e-059232PF12146
DomainHydrolase_4

ABHD17A ABHD17B

5.19e-059232IPR022742
DomainDAPIN

NLRP11 NLRP3

3.30e-0422232PS50824
DomainDAPIN

NLRP11 NLRP3

3.30e-0422232IPR004020
DomainPYRIN

NLRP11 NLRP3

3.30e-0422232SM01289
DomainPYRIN

NLRP11 NLRP3

3.30e-0422232PF02758
DomainEGF_3

MEGF8 TENM2 OTOG

2.89e-03235233PS50026
DomainEGF-like_dom

MEGF8 TENM2 OTOG

3.40e-03249233IPR000742
DomainLeu-rich_rpt

NLRP11 NLRC5 NLRP3

4.32e-03271233IPR001611
Domain-

NLRP11 NLRP3

5.80e-03932321.10.533.10
DomainDEATH-like_dom

NLRP11 NLRP3

6.54e-0399232IPR011029
Domain-

NLRP11 NLRC5 NLRP3

6.90e-033212333.80.10.10
DomainL_dom-like

NLRP11 NLRC5 NLRP3

7.33e-03328233IPR032675
Domain-

ABHD17A ABHD17B

9.33e-031192323.40.50.1820
DomainAB_hydrolase

ABHD17A ABHD17B

9.33e-03119232IPR029058
DomainEGF_CA

MEGF8 TENM2

9.79e-03122232SM00179
DomainEGF-like_Ca-bd_dom

MEGF8 TENM2

1.01e-02124232IPR001881
PathwayREACTOME_RAS_PROCESSING

ABHD17A ABHD17B

2.14e-0424132M38995
Pubmed

Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.

NLRP11 NLRC5 NLRP3

3.28e-09525312615073
Pubmed

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.

NLRC5 NLRP3

4.96e-07225223815151
Pubmed

Similar phenotypes caused by mutations in OTOG and OTOGL.

OTOGL OTOG

4.96e-07225224378291
Pubmed

The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis.

NLRC5 NLRP3

1.49e-06325231186034
Pubmed

ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.

ABHD17A NLRP3

2.97e-06425238092000
Pubmed

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.

ABHD17A ABHD17B

2.97e-06425226701913
Pubmed

The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.

USP50 NLRP3

2.97e-06425228094437
Pubmed

Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.

ABHD17A ABHD17B

4.95e-06525228521134
Pubmed

Identification of PSD-95 Depalmitoylating Enzymes.

ABHD17A ABHD17B

1.04e-05725227307232
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

OTOGL OTOG

2.72e-051125231776257
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP11 NLRP3

4.49e-051425220403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP11 NLRP3

4.49e-051425212563287
Pubmed

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

NLRC5 NLRP3

4.49e-051425226320999
Pubmed

EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.

TENM2 DNMT3B

5.18e-051525226576615
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

ABHD17A SPRY1 MEGF8 MYCBP2

6.43e-0456025421653829
Cytoband5q21.1

FAM174A SLCO6A1

5.38e-05202525q21.1
CytobandEnsembl 112 genes in cytogenetic band chr5q21

FAM174A SLCO6A1

6.53e-0469252chr5q21
CytobandEnsembl 112 genes in cytogenetic band chr4q28

SPRY1 PCDH10

8.98e-0481252chr4q28
Cytoband19p13.3

ABHD17A C2CD4C

7.36e-0323725219p13.3
GeneFamilyNLR family

NLRP11 NLRC5 NLRP3

1.05e-0625153666
GeneFamilyAbhydrolase domain containing

ABHD17A ABHD17B

1.47e-04221524
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP11 NLRP3

1.91e-0425152994
ComputationalGenes in the cancer module 292.

APOL3 NLRC5 MYCBP2

3.03e-04136113MODULE_292
ComputationalGenes in the cancer module 119.

APOL3 NLRC5 MYCBP2

3.52e-04143113MODULE_119
Diseaseanthropometric measurement

BNC2 MYCBP2 TENM2

2.95e-04168233EFO_0004302
Diseasenon-alcoholic fatty liver disease (implicated_via_orthology)

UBR1 NLRP3

3.60e-0436232DOID:0080208 (implicated_via_orthology)
Diseaseneutrophil count

ABHD17A NLRC5 BNC2 FAM174A MYCBP2 NLRP3

5.30e-041382236EFO_0004833
Diseasediabetes mellitus

MYCBP2 SLCO6A1

1.28e-0368232EFO_0000400
DiseaseNonsyndromic Deafness

OTOGL OTOG

1.81e-0381232C3711374
Diseasesuntan

BNC2 DNMT3B

2.91e-03103232EFO_0004279
Diseasetreatment-resistant hypertension

BNC2 PCDH10

3.25e-03109232EFO_1002006
Diseasecortical surface area measurement

ADAMTS18 BNC2 SPRY1 MYCBP2 TENM2

3.31e-031345235EFO_0010736
Diseaseacne

ADAMTS18 SPRY1

4.25e-03125232EFO_0003894
DiseaseAstigmatism

BNC2 TENM2

4.52e-03129232HP_0000483

Protein segments in the cluster

PeptideGeneStartEntry
ELLLCSNTSCCRCFC

DNMT3B

486

Q9UBC3
AIRCTLVNCTCECFQ

BNC2

111

Q6ZN30
MNGLSLSELCCLFCC

ABHD17A

1

Q96GS6
LCDARSINCCVGLCL

C2CD4C

336

Q8TF44
GRVAKALQLCCLCCA

ADAMTS18

26

Q8TE60
ALQLCCLCCASVAAA

ADAMTS18

31

Q8TE60
VLVFCCLTENCCSAL

NLRP11

781

P59045
SCSLGCAQATQCALC

MEGF8

2116

Q7Z7M0
AGSLLACCLNAACMA

EXOSC5

126

Q9NQT4
LNIYTCLASDCCLCC

PCDH10

746

Q9P2E7
SLCAVPALCQVACLC

NLRC5

401

Q86WI3
ATIAALVSCCVAKCC

CALHM4

196

Q5JW98
ASCFACLIRSCCQVV

APOL3

11

O95236
ACKCGSSCLCNALAH

OTOGL

706

Q3ZCN5
DLAACCGSCRNVSCL

OTOG

2751

Q6ZRI0
CCCCLSHLLASVLLL

FAM174A

6

Q8TBP5
SCCLTSACCQDLASV

NLRP3

836

Q96P20
LLLLLVVAHCCCCSS

SMIM22

46

K7EJ46
LGCLVSTCCECCNNI

SLCO6A1

91

Q86UG4
DCCLQSACQNSLLCR

TENM2

866

Q9NT68
AIILCNVCGNLCTDC

MYCBP2

4271

O75592
MNNLSFSELCCLFCC

ABHD17B

1

Q5VST6
LCLFCGAILCSQNIC

UBR1

1626

Q8IWV7
CLACNRQCLCSAESM

SPRY1

201

O43609
SALCAACCLLTSLCD

TMEM44

61

Q2T9K0
NTCCVNAISQCLCSI

USP50

51

Q70EL3