Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylethanolamine flippase activity	ATP11A ATP11B	1.08e-04	7	46	2	GO:0090555
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP11A ATP11B	1.85e-04	9	46	2	GO:0090556
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ATP11A ATP11B	4.64e-04	14	46	2	GO:0140333
GeneOntologyMolecularFunction	floppase activity	ATP11A ATP11B	6.10e-04	16	46	2	GO:0140328
GeneOntologyMolecularFunction	flippase activity	ATP11A ATP11B	6.91e-04	17	46	2	GO:0140327
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D8 ARFGEF1 DENND2A ARHGEF3 GDPGP1 MYO9A	1.03e-03	507	46	6	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D8 ARFGEF1 DENND2A ARHGEF3 GDPGP1 MYO9A	1.03e-03	507	46	6	GO:0030695
GeneOntologyMolecularFunction	enzyme regulator activity	TBC1D8 ARFGEF1 DENND2A SERPINE3 ARHGEF3 RCAN1 CTSA GDPGP1 MYO9A LGALS3	1.22e-03	1418	46	10	GO:0030234
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP11A ATP11B	1.89e-03	28	46	2	GO:0140326
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ARFGEF1 DENND2A ARHGEF3 GDPGP1	1.95e-03	231	46	4	GO:0005085
GeneOntologyMolecularFunction	ATP-dependent activity	MYO18A ATP11A SETX ATP11B MYO9A MOV10	2.71e-03	614	46	6	GO:0140657
GeneOntologyCellularComponent	ciliary pocket membrane	EHD1 EHD3	1.48e-05	3	47	2	GO:0020018
GeneOntologyCellularComponent	ciliary pocket	EHD1 EHD3	1.48e-05	3	47	2	GO:0020016
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP11A ATP11B	4.43e-04	14	47	2	GO:1990531
Domain	G_DYNAMIN_dom	MFN2 EHD1 EHD3	4.99e-06	14	46	3	IPR030381
Domain	G_DYNAMIN_2	MFN2 EHD1 EHD3	4.99e-06	14	46	3	PS51718
Domain	EHD1/EHD3	EHD1 EHD3	5.93e-06	2	46	2	IPR029951
Domain	Dynamin_SF	MFN2 EHD1 EHD3	6.23e-06	15	46	3	IPR022812
Domain	Dynamin_GTPase	MFN2 EHD1 EHD3	6.23e-06	15	46	3	IPR001401
Domain	Dynamin_N	MFN2 EHD1 EHD3	6.23e-06	15	46	3	PF00350
Domain	EHD_N	EHD1 EHD3	5.91e-05	5	46	2	PF16880
Domain	EHD_N	EHD1 EHD3	5.91e-05	5	46	2	IPR031692
Domain	EF-hand_4	EHD1 EHD3	2.64e-04	10	46	2	PF12763
Domain	EH	EHD1 EHD3	3.22e-04	11	46	2	PS50031
Domain	EH	EHD1 EHD3	3.22e-04	11	46	2	SM00027
Domain	EH_dom	EHD1 EHD3	3.22e-04	11	46	2	IPR000261
Domain	P_typ_ATPase_c	ATP11A ATP11B	5.30e-04	14	46	2	IPR032630
Domain	P-type_ATPase_N	ATP11A ATP11B	5.30e-04	14	46	2	IPR032631
Domain	P-type_ATPase_IV	ATP11A ATP11B	5.30e-04	14	46	2	IPR006539
Domain	PhoLip_ATPase_C	ATP11A ATP11B	5.30e-04	14	46	2	PF16212
Domain	PhoLip_ATPase_N	ATP11A ATP11B	5.30e-04	14	46	2	PF16209
Domain	P-loop_NTPase	MYO18A MFN2 SETX UTP25 MYO9A MOV10 EHD1 EHD3	9.83e-04	848	46	8	IPR027417
Domain	-	MYO18A MFN2 SETX UTP25 MOV10 EHD1 EHD3	2.17e-03	746	46	7	3.40.50.300
Domain	-	ATP11A ATP11B	2.81e-03	32	46	2	2.70.150.10
Domain	-	ATP11A ATP11B	2.81e-03	32	46	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP11A ATP11B	3.35e-03	35	46	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP11A ATP11B	3.54e-03	36	46	2	IPR018303
Domain	P_typ_ATPase	ATP11A ATP11B	3.54e-03	36	46	2	IPR001757
Domain	ATPASE_E1_E2	ATP11A ATP11B	3.54e-03	36	46	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP11A ATP11B	3.74e-03	37	46	2	IPR008250
Domain	E1-E2_ATPase	ATP11A ATP11B	3.74e-03	37	46	2	PF00122
Domain	MYOSIN_MOTOR	MYO18A MYO9A	3.94e-03	38	46	2	PS51456
Domain	Myosin_head	MYO18A MYO9A	3.94e-03	38	46	2	PF00063
Domain	Myosin_head_motor_dom	MYO18A MYO9A	3.94e-03	38	46	2	IPR001609
Domain	MYSc	MYO18A MYO9A	3.94e-03	38	46	2	SM00242
Domain	Cadherin_C_2	PCDHB14 PCDHB9	4.80e-03	42	46	2	PF16492
Domain	PRY	TRIM39 TRIM7	4.80e-03	42	46	2	PF13765
Domain	Cadherin_C	PCDHB14 PCDHB9	4.80e-03	42	46	2	IPR032455
Domain	PRY	TRIM39 TRIM7	6.23e-03	48	46	2	SM00589
Domain	PRY	TRIM39 TRIM7	6.23e-03	48	46	2	IPR006574
Pubmed	Reanalysis of ATP11B, a type IV P-type ATPase.	ATP11A ATP11B	1.79e-06	2	47	2	11790799
Pubmed	SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.	EHD1 EHD3	1.79e-06	2	47	2	26226295
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	MYO18A ACE2 WASHC4 COG3 ERO1A MOV10 TRIM7	4.84e-06	503	47	7	36217030
Pubmed	Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis.	MFN2 DNMT1	5.36e-06	3	47	2	31104361
Pubmed	The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP1.	SETX PIAS2	5.36e-06	3	47	2	30389781
Pubmed	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	EHD1 EHD3	5.36e-06	3	47	2	24019528
Pubmed	Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.	EHD1 EHD3	5.36e-06	3	47	2	25686250
Pubmed	EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.	EHD1 EHD3	5.36e-06	3	47	2	12121420
Pubmed	Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1α expression via cooperation between DNMT1 and G9a.	ERO1A DNMT1	5.36e-06	3	47	2	35347798
Pubmed	Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.	RCAN1 DNMT1	5.36e-06	3	47	2	31285763
Pubmed	Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.	ACE2 UTS2	5.36e-06	3	47	2	16866021
Pubmed	Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.	EHD1 EHD3	1.07e-05	4	47	2	16251358
Pubmed	Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.	HTR3C PARL	1.07e-05	4	47	2	28813580
Pubmed	C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?	EHD1 EHD3	1.07e-05	4	47	2	16155252
Pubmed	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	EHD1 EHD3	1.07e-05	4	47	2	27189942
Pubmed	Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.	EHD1 EHD3	1.07e-05	4	47	2	29212907
Pubmed	BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.	ARFGEF1 MYO9A	1.07e-05	4	47	2	15644318
Pubmed	Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.	EHD1 EHD3	1.07e-05	4	47	2	17233914
Pubmed	EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.	EHD1 EHD3	1.07e-05	4	47	2	10673336
Pubmed	ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.	HTR3C PARL	1.07e-05	4	47	2	24603532
Pubmed	Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.	EHD1 EHD3	1.07e-05	4	47	2	15020713
Pubmed	EH domain proteins regulate cardiac membrane protein targeting.	EHD1 EHD3	1.78e-05	5	47	2	20489164
Pubmed	ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.	ATP11A ATP11B	1.78e-05	5	47	2	31571211
Pubmed	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.	EHD1 EHD3	2.67e-05	6	47	2	19864458
Pubmed	Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.	EHD1 EHD3	4.98e-05	8	47	2	17507647
Pubmed	Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study.	MFN2 PARL	6.40e-05	9	47	2	19754948
Pubmed	Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.	EHD1 EHD3	6.40e-05	9	47	2	11423532
Pubmed	The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.	EHD1 EHD3	9.75e-05	11	47	2	26455409
Pubmed	ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.	ATP11A ATP11B	1.17e-04	12	47	2	21914794
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP11A ATP11B	1.38e-04	13	47	2	11015572
Pubmed	Protocadherins.	PCDHB14 PCDHB9	1.38e-04	13	47	2	12231349
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SETX VRK3 RPA1 TRRAP PIAS2 DNMT1	1.63e-04	608	47	6	36089195
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYO18A RPA1 MYO9A EHD3	1.81e-04	208	47	4	33230847
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	MFN2 ARHGEF3 EHD3	1.83e-04	81	47	3	22139419
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MFN2 ATP11A SETX CTSA RPA1 TRRAP ERO1A DNMT1	3.15e-04	1297	47	8	33545068
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB14 PCDHB9	3.34e-04	20	47	2	11322959
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SETX TRRAP MOV10 HECTD4	3.65e-04	250	47	4	33536335
Pubmed	SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.	RPA1 DNMT1	3.69e-04	21	47	2	24958773
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	MOV10 HECTD4	3.69e-04	21	47	2	25249183
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	SETX PIAS2	4.06e-04	22	47	2	16524884
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETX WASHC4 RPA1 TRRAP MYO9A MOV10 EHD1 DNMT1	4.18e-04	1353	47	8	29467282
Pubmed	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.	COG3 CTSA EHD1 EHD3	4.41e-04	263	47	4	12665801
Pubmed	Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.	APOBEC2 DNMT1	4.84e-04	24	47	2	23920106
Pubmed	NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.	MFN2 DNMT1	5.26e-04	25	47	2	37493331
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	COG3 VRK3 CTSA RPA1 ERO1A LGALS3 MOV10 EHD1	6.31e-04	1440	47	8	30833792
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	SETX TRRAP PIAS2	6.55e-04	125	47	3	32891193
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	EHD1 EHD3	6.61e-04	28	47	2	26884322
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DENND2A SETX WASHC4 ATP11B HECTD4	7.24e-04	529	47	5	14621295
Pubmed	A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.	RPA1 DNMT1	8.11e-04	31	47	2	12171929
Pubmed	Defining the membrane proteome of NK cells.	MYO18A ATP11A ATP11B CTSA ERO1A LGALS3 EHD1	9.20e-04	1168	47	7	19946888
Pubmed	A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.	ARHGEF3 EHD3	9.75e-04	34	47	2	19820697
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	ARHGEF3 EHD3	9.75e-04	34	47	2	24026423
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	RPA1 TRRAP PIAS2 DNMT1	1.14e-03	339	47	4	30415952
Interaction	RDH11 interactions	ACE2 HTR3C RPA1 TRRAP TECTB	7.76e-06	120	46	5	int:RDH11
Interaction	NAXE interactions	MFN2 CTSA RPA1 EHD1	1.05e-05	60	46	4	int:NAXE
Interaction	TRIM16 interactions	ARFGEF1 LGALS3 MOV10 TRIM7	1.20e-05	62	46	4	int:TRIM16
Interaction	SCP2D1 interactions	EHD1 EHD3	1.53e-05	3	46	2	int:SCP2D1
Cytoband	3q27.1	HTR3C PARL	3.54e-04	27	47	2	3q27.1
GeneFamily	UPF1 like RNA helicases	SETX MOV10	1.76e-04	11	33	2	1169
GeneFamily	ATPase phospholipid transporting	ATP11A ATP11B	3.34e-04	15	33	2	1210
GeneFamily	Clustered protocadherins	PCDHB14 PCDHB9	6.07e-03	64	33	2	20
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM39 TRIM7	1.30e-02	95	33	2	59
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A_EA	TBC1D8 ARFGEF1 SETX MYO9A EHD1 EHD3	3.29e-06	199	47	6	1055_DN
Drug	Glafenine	MYO18A TBC1D8 ARFGEF1 MFN2 ATP11A WASHC4 COG3 CTSA RPA1 LGALS3 CYP27A1 PBDC1	1.14e-05	1327	47	12	ctd:D005897
Disease	EH domain-containing protein 4 measurement	ARHGEF3 EHD3	2.27e-06	2	45	2	EFO_0802519
Disease	glucosamine 6-phosphate N-acetyltransferase measurement	ARHGEF3 ERO1A	1.36e-05	4	45	2	EFO_0801626
Disease	splicing factor 3B subunit 4 measurement	MFN2 ARHGEF3	2.27e-05	5	45	2	EFO_0803100
Disease	reticulocyte count	TBC1D8 ATP11A ARHGEF3 ATP11B CYP27A1 DNMT1 EHD3 HECTD4	1.62e-04	1045	45	8	EFO_0007986
Disease	hypertrophic cardiomyopathy (is_marker_for)	ACE2 DNMT1	3.05e-04	17	45	2	DOID:11984 (is_marker_for)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MFN2 GDAP1L1	6.14e-04	24	45	2	DOID:10595 (implicated_via_orthology)
Disease	mean arterial pressure	ARHGEF3 UTP25 MOV10 DNMT1 HECTD4	9.49e-04	499	45	5	EFO_0006340
Disease	reticulocyte measurement	TBC1D8 ATP11A ARHGEF3 ATP11B DNMT1 EHD3 HECTD4	1.00e-03	1053	45	7	EFO_0010700
Disease	type 2 diabetes mellitus (is_marker_for)	MFN2 UTS2 PARL	1.18e-03	136	45	3	DOID:9352 (is_marker_for)
Disease	platelet measurement	MFN2 ARHGEF3 MOV10 EHD3	1.34e-03	315	45	4	EFO_0005036

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGAFSNNERIKNFFR	ARHGEF3	401	Q9NR81
RFFLLENVRNFVSFK	DNMT1	1261	P26358
ELANFRFQKDFLRPF	ARFGEF1	1226	Q9Y6D6
QAVFDRKAFRPFTNY	HTR3C	46	Q8WXA8
RLPANFFKFQFRNVE	APOBEC2	46	Q9Y235
FKRVRINFSNPFSAA	RCAN1	106	P53805
PNLQSFFERVQRRFA	GDAP1L1	296	Q96MZ0
AFHFNPRFNENNRRV	LGALS3	156	P17931
FAPRIQFFAIEIARN	PBDC1	136	Q9BVG4
RQAFDPVQFNFNKIR	GDPGP1	116	Q6ZNW5
FKFFFSPQTERNRDI	HECTD4	296	Q9Y4D8
FQVRMFEFQNFERRF	MFN2	331	O95140
QSNFEALQDFFRLFP	CTSA	151	P10619
FQVVLENPLQFFRFE	PCDHB14	106	Q9Y5E9
VFQNANFRSFIFRVR	RPA1	561	P27694
PAFFRQNSERRNFKL	DENND2A	421	Q9ULE3
PRFFRLNSNNALIEF	COG3	656	Q96JB2
PRLGQLRFFFQLFVQ	CYP27A1	61	Q02318
RVANLKPRISFNFFV	ACE2	671	Q9BYF1
FFERPDFQLFTGNKI	ERO1A	321	Q96HE7
VNKNSVLPQAFDRFF	HOXC11	141	O43248
ANPFLYAIFTKNFRR	FSHR	621	P23945
PFRKLNAFGNAFLNR	EHD1	121	Q9H4M9
IQRFQEKFFIFALTP	PIAS2	171	O75928
FSFPRQRQVLFLFLF	PCDHB9	6	Q9Y5E1
PQLLGRRFNFFIQQK	PARL	36	Q9H300
RRFNFFIQQKCGFRK	PARL	41	Q9H300
IDARFNFFVNKILPQ	UTP25	591	Q68CQ4
NIFNPRGNLRKFQDF	UTS2	76	O95399
KNFSNFPRQYFALRK	TRIM39	316	Q9HCM9
LTFKVNFTFNRQPLR	MOV10	441	Q9HCE1
SPNRENFYQLQVRKF	SETX	1766	Q7Z333
RATFQFNAFRFQNIP	TECTB	241	Q96PL2
PFRKLNAFGNAFLNR	EHD3	121	Q9NZN3
IPKNLFEQFRRVANF	ATP11A	61	P98196
PKNLFEQFRRVANFY	ATP11B	56	Q9Y2G3
FFPRNINRDFSNGFL	SPATA4	66	Q8NEY3
RFQQTARPTFFARKF	XYLT1	586	Q86Y38
FRVNFQERVFPLFSV	TRIM7	486	Q9C029
RAQNEFFRAFFRLPR	TBC1D8	281	O95759
RAITVFRPQNFNQFF	WDR49	256	Q8IV35
VFLPRFRIQNQFNLK	SERPINE3	296	A8MV23
LFNEQNFFQRAAKPL	VRK3	211	Q8IV63
FSLNPIRFFNRFIDI	WASHC4	711	Q2M389
FFFQRNPYFRNKLIV	TSPYL6	296	Q8N831
IAQKRALFFRFVDFN	TRRAP	1746	Q9Y4A5
LFKVNPFQLQQFRAD	MYO18A	76	O95411
RNIIPSKFNIQDFFR	MYO9A	971	B2RTY4