Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	ACTN4 MYH8 ACTN1 ACTN2 XIRP2	1.23e-04	227	43	5	GO:0051015
GeneOntologyMolecularFunction	unmethylated CpG binding	KDM2B CXXC1	2.02e-04	10	43	2	GO:0045322
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	ACTN4 ACTN1 ACTN2	3.07e-04	61	43	3	GO:0030374
GeneOntologyMolecularFunction	molecular adaptor activity	FBXO7 KDM2B DLG5 ACTN4 ACTN1 ACTN2 PHF10 ST13 ITSN1 TPX2	4.90e-04	1356	43	10	GO:0060090
GeneOntologyMolecularFunction	integrin binding	ACTN4 ACTN1 ACTN2 ECM2	5.39e-04	175	43	4	GO:0005178
GeneOntologyBiologicalProcess	regulation of double-strand break repair	MEAF6 FANCB TEX15 ERCC6 PHF10	1.29e-05	146	43	5	GO:2000779
GeneOntologyBiologicalProcess	regulation of double-strand break repair via homologous recombination	MEAF6 FANCB TEX15 ERCC6	2.67e-05	83	43	4	GO:0010569
GeneOntologyBiologicalProcess	positive regulation of double-strand break repair	MEAF6 FANCB ERCC6 PHF10	4.54e-05	95	43	4	GO:2000781
GeneOntologyBiologicalProcess	positive regulation of double-strand break repair via homologous recombination	MEAF6 FANCB ERCC6	1.05e-04	44	43	3	GO:1905168
GeneOntologyBiologicalProcess	rRNA transcription	ERCC6 GTF3C1 MTOR	1.20e-04	46	43	3	GO:0009303
GeneOntologyBiologicalProcess	regulation of DNA repair	MEAF6 FANCB TEX15 ERCC6 PHF10	1.22e-04	234	43	5	GO:0006282
GeneOntologyBiologicalProcess	cell junction organization	GABRG3 DLG5 ACTN4 ACTN1 ACTN2 PPFIA3 XIRP2 ITSN1 CACNA2D3	1.49e-04	974	43	9	GO:0034330
GeneOntologyBiologicalProcess	dendritic spine development	ACSL4 DLG5 MTOR ITSN1	2.10e-04	141	43	4	GO:0060996
GeneOntologyBiologicalProcess	positive regulation of DNA repair	MEAF6 FANCB ERCC6 PHF10	2.22e-04	143	43	4	GO:0045739
GeneOntologyBiologicalProcess	regulation of DNA recombination	MEAF6 FANCB TEX15 ERCC6	2.66e-04	150	43	4	GO:0000018
GeneOntologyBiologicalProcess	transcription by RNA polymerase III	ERCC6 GTF3C1 MTOR	3.07e-04	63	43	3	GO:0006383
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN1 ACTN2	6.03e-06	18	42	3	GO:0031143
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	ACTN4 ACTN2 ITSN1	7.15e-06	19	42	3	GO:0098871
GeneOntologyCellularComponent	postsynaptic cytoskeleton	ACTN4 ACTN2 ITSN1	1.90e-05	26	42	3	GO:0099571
GeneOntologyCellularComponent	sarcomere	ACTN4 MYH8 ACTN1 ACTN2 XIRP2	1.37e-04	249	42	5	GO:0030017
GeneOntologyCellularComponent	myofibril	ACTN4 MYH8 ACTN1 ACTN2 XIRP2	2.10e-04	273	42	5	GO:0030016
GeneOntologyCellularComponent	Z disc	ACTN4 ACTN1 ACTN2 XIRP2	2.37e-04	151	42	4	GO:0030018
GeneOntologyCellularComponent	contractile muscle fiber	ACTN4 MYH8 ACTN1 ACTN2 XIRP2	2.77e-04	290	42	5	GO:0043292
GeneOntologyCellularComponent	platelet alpha granule lumen	ACTN4 ACTN1 ACTN2	3.30e-04	67	42	3	GO:0031093
GeneOntologyCellularComponent	I band	ACTN4 ACTN1 ACTN2 XIRP2	3.39e-04	166	42	4	GO:0031674
GeneOntologyCellularComponent	cortical actin cytoskeleton	ACTN4 ACTN1 ACTN2	8.63e-04	93	42	3	GO:0030864
GeneOntologyCellularComponent	platelet alpha granule	ACTN4 ACTN1 ACTN2	8.63e-04	93	42	3	GO:0031091
GeneOntologyCellularComponent	actin cytoskeleton	ACTN4 MYH8 ACTN1 ACTN2 XIRP2 ITSN1	9.62e-04	576	42	6	GO:0015629
GeneOntologyCellularComponent	contractile actin filament bundle	ACTN4 ACTN1 XIRP2	1.29e-03	107	42	3	GO:0097517
GeneOntologyCellularComponent	stress fiber	ACTN4 ACTN1 XIRP2	1.29e-03	107	42	3	GO:0001725
GeneOntologyCellularComponent	actomyosin	ACTN4 ACTN1 XIRP2	1.67e-03	117	42	3	GO:0042641
GeneOntologyCellularComponent	actin filament bundle	ACTN4 ACTN1 XIRP2	1.71e-03	118	42	3	GO:0032432
GeneOntologyCellularComponent	cortical cytoskeleton	ACTN4 ACTN1 ACTN2	2.21e-03	129	42	3	GO:0030863
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	MEAF6 PHF20L1	3.69e-03	45	42	2	GO:1902562
GeneOntologyCellularComponent	postsynapse	GABRG3 DLG5 ACTN4 ACTN1 ACTN2 MTOR ITSN1	3.85e-03	1018	42	7	GO:0098794
GeneOntologyCellularComponent	glutamatergic synapse	DLG5 ACTN1 ACTN2 PPFIA3 MTOR ITSN1	5.52e-03	817	42	6	GO:0098978
Domain	EF-hand_Ca_insen	ACTN4 ACTN1 ACTN2	2.26e-07	6	43	3	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN1 ACTN2	2.26e-07	6	43	3	PF08726
Domain	Actinin_actin-bd_CS	ACTN4 ACTN1 ACTN2	1.95e-05	23	43	3	IPR001589
Domain	ACTININ_2	ACTN4 ACTN1 ACTN2	1.95e-05	23	43	3	PS00020
Domain	ACTININ_1	ACTN4 ACTN1 ACTN2	1.95e-05	23	43	3	PS00019
Domain	Spectrin	ACTN4 ACTN1 ACTN2	1.95e-05	23	43	3	PF00435
Domain	Spectrin_repeat	ACTN4 ACTN1 ACTN2	3.98e-05	29	43	3	IPR002017
Domain	Spectrin/alpha-actinin	ACTN4 ACTN1 ACTN2	5.38e-05	32	43	3	IPR018159
Domain	SPEC	ACTN4 ACTN1 ACTN2	5.38e-05	32	43	3	SM00150
Domain	ZF_PHD_1	KDM2B PHF20L1 PHF10 CXXC1	6.94e-05	96	43	4	PS01359
Domain	zf-CXXC	KDM2B CXXC1	2.81e-04	11	43	2	PF02008
Domain	Znf_CXXC	KDM2B CXXC1	2.81e-04	11	43	2	IPR002857
Domain	ZF_CXXC	KDM2B CXXC1	2.81e-04	11	43	2	PS51058
Domain	Znf_FYVE_PHD	KDM2B PHF20L1 PHF10 CXXC1	3.58e-04	147	43	4	IPR011011
Domain	CH	ACTN4 ACTN1 ACTN2	4.49e-04	65	43	3	SM00033
Domain	EFh	ACTN4 ACTN1 ACTN2 ITSN1	4.71e-04	158	43	4	SM00054
Domain	CH	ACTN4 ACTN1 ACTN2	5.59e-04	70	43	3	PF00307
Domain	-	ACTN4 ACTN1 ACTN2	5.83e-04	71	43	3	1.10.418.10
Domain	CH	ACTN4 ACTN1 ACTN2	6.32e-04	73	43	3	PS50021
Domain	CH-domain	ACTN4 ACTN1 ACTN2	6.84e-04	75	43	3	IPR001715
Domain	Znf_PHD-finger	KDM2B PHF10 CXXC1	7.96e-04	79	43	3	IPR019787
Domain	PHD	KDM2B PHF10 CXXC1	1.12e-03	89	43	3	SM00249
Domain	Znf_PHD	KDM2B PHF10 CXXC1	1.20e-03	91	43	3	IPR001965
Domain	ZF_PHD_2	KDM2B PHF10 CXXC1	1.36e-03	95	43	3	PS50016
Domain	EF_HAND_2	ACTN4 ACTN1 ACTN2 ITSN1	1.93e-03	231	43	4	PS50222
Domain	EF_hand_dom	ACTN4 ACTN1 ACTN2 ITSN1	1.96e-03	232	43	4	IPR002048
Domain	-	ACTN4 ACTN1 ACTN2 ITSN1	3.00e-03	261	43	4	1.10.238.10
Domain	EF-hand-dom_pair	ACTN4 ACTN1 ACTN2 ITSN1	4.21e-03	287	43	4	IPR011992
Domain	EF-hand_1	ACTN4 ACTN1 ACTN2	5.14e-03	152	43	3	PF00036
Domain	FBOX	FBXO7 KDM2B	6.38e-03	52	43	2	SM00256
Domain	EF_Hand_1_Ca_BS	ACTN4 ACTN1 ITSN1	7.58e-03	175	43	3	IPR018247
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	ACTN4 ACTN1 ACTN2	2.20e-05	23	34	3	M913
Pathway	KEGG_ADHERENS_JUNCTION	ACTN4 ACTN1 ACTN2 SSX2IP	2.73e-05	73	34	4	M638
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	ACTN4 ACTN1 ACTN2 CACNA2D3	2.88e-05	74	34	4	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	ACTN4 ACTN1 ACTN2 CACNA2D3	2.88e-05	74	34	4	M16376
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	ACTN4 MYH8 ACTN2	1.02e-04	38	34	3	M39549
Pathway	KEGG_TIGHT_JUNCTION	ACTN4 MYH8 ACTN1 ACTN2	2.74e-04	132	34	4	M11355
Pathway	BIOCARTA_CELL2CELL_PATHWAY	ACTN1 ACTN2	3.67e-04	12	34	2	M12851
Pathway	BIOCARTA_UCALPAIN_PATHWAY	ACTN1 ACTN2	5.05e-04	14	34	2	M13143
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN1 ACTN2	7.04e-09	4	43	3	1629252
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN1 ACTN2	7.04e-09	4	43	3	16807302
Pubmed	ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.	ACTN1 ACTN2 SSX2IP	7.04e-09	4	43	3	12446711
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN1 ACTN2	1.76e-08	5	43	3	15841212
Pubmed	The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.	ACTN4 ACTN1 ACTN2	1.76e-08	5	43	3	12837758
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	ACTN4 ACTN1 ACTN2	1.76e-08	5	43	3	19943616
Pubmed	Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.	ACTN4 ACTN1 ACTN2	3.51e-08	6	43	3	18425115
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN4 ACTN1 ACTN2	3.51e-08	6	43	3	22693585
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	ACTN4 ACTN1 ACTN2	6.14e-08	7	43	3	11724819
Pubmed	Mice deficient in alpha-actinin-4 have severe glomerular disease.	ACTN4 ACTN1 ACTN2	9.82e-08	8	43	3	12782671
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	ACTN4 ACTN1 ACTN2	9.82e-08	8	43	3	20215401
Pubmed	Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.	ACTN4 ACTN1 ACTN2	2.10e-07	10	43	3	20368620
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	ACTN4 ACTN1 ACTN2	3.84e-07	12	43	3	15465019
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	ACTN4 GTF3C1 PHF10 CXXC1 ZMYM4 TPX2 FTSJ3	6.72e-07	410	43	7	26949251
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ACTN4 ACTN1 ACTN2	7.93e-07	15	43	3	11440986
Pubmed	Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.	GABRG3 ACTN2 CACNA2D3	1.42e-06	18	43	3	27405468
Pubmed	Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.	ACTN4 ACTN1	1.49e-06	2	43	2	34010028
Pubmed	Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.	ACSL4 MTOR	1.49e-06	2	43	2	26536660
Pubmed	An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins.	ACTN4 ACTN1	1.49e-06	2	43	2	23557398
Pubmed	Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.	ACTN4 ACTN1	1.49e-06	2	43	2	20037648
Pubmed	HAMLET binding to α-actinin facilitates tumor cell detachment.	ACTN4 ACTN1	1.49e-06	2	43	2	21408150
Pubmed	Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells.	ACTN4 ACTN1	1.49e-06	2	43	2	28797528
Pubmed	α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.	ACTN4 ACTN1	1.49e-06	2	43	2	23454549
Pubmed	Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.	ACTN4 ACTN1	1.49e-06	2	43	2	20156433
Pubmed	Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.	ACTN1 ACTN2	1.49e-06	2	43	2	23664615
Pubmed	Direct binding of alpha-actinin enhances TRPP3 channel activity.	ACTN1 ACTN2	4.48e-06	3	43	2	17944866
Pubmed	Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.	ACTN1 ACTN2	4.48e-06	3	43	2	30768638
Pubmed	Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin.	ACTN4 ACTN1	4.48e-06	3	43	2	16751418
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN1	4.48e-06	3	43	2	21784188
Pubmed	Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.	ACTN4 ACTN1	4.48e-06	3	43	2	23890175
Pubmed	The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.	ACTN4 ACTN2	4.48e-06	3	43	2	10656685
Pubmed	Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.	ACTN4 ACTN2	4.48e-06	3	43	2	21940706
Pubmed	The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism.	ACTN1 ACTN2	4.48e-06	3	43	2	11101506
Pubmed	Interaction of PKN with alpha-actinin.	ACTN1 ACTN2	4.48e-06	3	43	2	9030526
Pubmed	Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis.	ACTN4 ACTN1	4.48e-06	3	43	2	16951376
Pubmed	Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.	ACTN4 ACTN2	4.48e-06	3	43	2	8104223
Pubmed	Agrin has a pathological role in the progression of oral cancer.	DLG5 ACTN4 MYH8 ACTN1 ACTN2	4.48e-06	197	43	5	29872149
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	ACTN4 ACTN1 ACTN2	5.04e-06	27	43	3	36899856
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	ERCC6 MAP7 SSX2IP TPX2 FTSJ3	6.11e-06	210	43	5	16565220
Pubmed	Human transcription factor protein interaction networks.	MEAF6 KDM2B MAP7 GTF3C1 ZNF607 PHF10 CXXC1 ZMYM4 TPX2 FTSJ3	7.37e-06	1429	43	10	35140242
Pubmed	Widespread macromolecular interaction perturbations in human genetic disorders.	FBXO7 ACTN4 ACTN1 ACTN2 BHLHE40 TMCC2 SSX2IP	7.40e-06	590	43	7	25910212
Pubmed	Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.	ACTN4 ACTN1 ACTN2	7.72e-06	31	43	3	14630798
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL4 ACTN4 MYH8 ACTN1 ACTN2 GTF3C1 PHF20L1 CCDC191 CXXC1 ITSN1	7.98e-06	1442	43	10	35575683
Pubmed	Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.	ACTN4 ACTN1	8.94e-06	4	43	2	23515331
Pubmed	An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.	ACTN4 ACTN1	8.94e-06	4	43	2	2116421
Pubmed	Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors.	ACTN4 ACTN2	8.94e-06	4	43	2	16510730
Pubmed	Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.	ACTN4 ACTN1	8.94e-06	4	43	2	22351778
Pubmed	CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.	ACTN4 ACTN1	8.94e-06	4	43	2	10753915
Pubmed	Titin mutations as the molecular basis for dilated cardiomyopathy.	ACTN1 ACTN2	8.94e-06	4	43	2	11846417
Pubmed	Interactions of a hemidesmosome component and actinin family members.	ACTN4 ACTN1	8.94e-06	4	43	2	11739652
Pubmed	Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.	ACTN1 ACTN2	8.94e-06	4	43	2	9501083
Pubmed	Structural dynamics of alpha-actinin-vinculin interactions.	ACTN4 ACTN1	8.94e-06	4	43	2	15988023
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MEAF6 KDM2B ERCC6 GTF3C1 PHF20L1 ZMYM4 TPX2	9.00e-06	608	43	7	36089195
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	ACTN4 ACTN1 ACTN2 ST13	1.10e-05	111	43	4	21163940
Pubmed	Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.	ACTN1 ACTN2	1.49e-05	5	43	2	15665106
Pubmed	mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.	GTF3C1 MTOR	1.49e-05	5	43	2	20543138
Pubmed	The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte.	ACTN4 ACTN1	1.49e-05	5	43	2	16501493
Pubmed	The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin.	ACTN4 ACTN1	2.23e-05	6	43	2	15070900
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MEAF6 KDM2B MAP7 GTF3C1 BHLHE40 CXXC1 ZMYM4 TPX2 FTSJ3	2.39e-05	1294	43	9	30804502
Pubmed	Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development.	ACTN1 ACTN2	3.12e-05	7	43	2	15721864
Pubmed	An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.	ACTN1 ACTN2	3.12e-05	7	43	2	31573406
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ACTN4 MYH8 ACTN2 XIRP2 ST13 ZMYM4	3.22e-05	497	43	6	23414517
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	GTF3C1 PHF20L1 ZMYM4 TPX2	3.60e-05	150	43	4	28242625
Pubmed	Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.	ACTN1 ACTN2	5.35e-05	9	43	2	11114196
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MEAF6 ERCC6 PPFIA3 MAP7 PHF10 ARAP2 SSX2IP FTSJ3	5.86e-05	1116	43	8	31753913
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FBXO7 ACTN1 ACTN2 BHLHE40 CXXC1 ITSN1	6.24e-05	560	43	6	21653829
Pubmed	Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.	ACTN1 ACTN2	8.15e-05	11	43	2	11842093
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KDM2B DLG5 MAP7 ST13 ZMYM4 ITSN1	8.16e-05	588	43	6	38580884
Pubmed	FCHo proteins are nucleators of clathrin-mediated endocytosis.	ACTN4 ITSN1	1.15e-04	13	43	2	20448150
Pubmed	Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.	ACTN4 ACTN1	1.15e-04	13	43	2	28079882
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	DLG5 ACTN4 MAP7 SSX2IP	1.30e-04	209	43	4	36779422
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	DLG5 ACTN4 ACTN1 GTF3C1 ST13	1.30e-04	399	43	5	37536630
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DLG5 ACTN4 ACTN1 ERCC6 MAP7 GTF3C1 TPX2 FTSJ3	1.34e-04	1257	43	8	36526897
Pubmed	Mechanical regulation of glycolysis via cytoskeleton architecture.	ACTN4 ACTN1	1.35e-04	14	43	2	32051585
Pubmed	Filamin C is Essential for mammalian myocardial integrity.	ACTN4 ACTN2	1.35e-04	14	43	2	36706168
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	ACSL4 ACTN4 MYH8 ACTN1 ACTN2 MTOR	1.37e-04	647	43	6	26618866
Pubmed	Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.	ACTN4 ACTN1	1.77e-04	16	43	2	16944923
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	ACTN4 ACTN1	1.77e-04	16	43	2	35390516
Pubmed	A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.	ACTN1 ACTN2	2.26e-04	18	43	2	24840128
Pubmed	Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1.	MYH8 ACTN2	2.26e-04	18	43	2	26688546
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MYH8 XIRP2	2.80e-04	20	43	2	21689717
Pubmed	Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.	MYH8 ACTN2	2.80e-04	20	43	2	7588068
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	ACTN4 ACTN1 ACTN2 BHLHE40 TMCC2 SSX2IP	2.88e-04	742	43	6	26871637
Pubmed	Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.	ACTN4 ACTN1	3.09e-04	21	43	2	12202484
Pubmed	Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function.	ACTN4 ACTN1	3.09e-04	21	43	2	16196101
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	PHF10 ST13 ITSN1	3.11e-04	106	43	3	18654987
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ACTN4 ACTN1 ACTN2 PPFIA3 MAP7 ST13 ITSN1 CACNA2D3	3.23e-04	1431	43	8	37142655
Pubmed	A human MAP kinase interactome.	ACTN4 ACTN1 BHLHE40 ST13 ITSN1	3.24e-04	486	43	5	20936779
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	ACTN2 ITSN1	3.40e-04	22	43	2	12812986
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KDM2B GTF3C1 PHF10 ZMYM4 ITSN1 TPX2	3.60e-04	774	43	6	15302935
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ERCC6 MAP7 GTF3C1 TPX2 FTSJ3	3.80e-04	503	43	5	16964243
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	ACTN4 ACTN1 ACTN2	4.26e-04	118	43	3	21078624
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	FBXO7 MTOR	4.40e-04	25	43	2	35211260
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	ACTN1 GTF3C1 MTOR ST13	4.41e-04	288	43	4	23383273
Pubmed	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	ACTN4 ACTN2	5.53e-04	28	43	2	30947518
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KDM2B ACTN1 GTF3C1 ZMYM4 TPX2	5.65e-04	549	43	5	38280479
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ACTN4 ERCC6 GTF3C1 ZMYM4 TPX2 FTSJ3	5.79e-04	847	43	6	35850772
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	ACSL4 ACTN4 ACTN1 MTOR	5.95e-04	312	43	4	37120454
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MEAF6 ACSL4 GTF3C1 PHF20L1 ZMYM4 TPX2	6.16e-04	857	43	6	25609649
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	MYH8 CILP	6.79e-04	31	43	2	16140986
Interaction	ELF4 interactions	FBXO7 KDM2B PHF10 CXXC1 ZMYM4	4.49e-06	115	43	5	int:ELF4
Interaction	NFIX interactions	KDM2B ACTN4 ACTN2 GTF3C1 CXXC1 ZMYM4	8.23e-06	227	43	6	int:NFIX
Interaction	MYOZ2 interactions	ACTN4 ACTN1 ACTN2	1.35e-05	22	43	3	int:MYOZ2
Interaction	TPM1 interactions	DLG5 ACTN4 MYH8 ACTN1 ACTN2 RHOBTB2	1.90e-05	263	43	6	int:TPM1
Interaction	ADORA2A interactions	ACTN4 ACTN1 ACTN2	2.55e-05	27	43	3	int:ADORA2A
Interaction	EGR2 interactions	MEAF6 KDM2B SOX8 PHF10 ZMYM4	3.08e-05	171	43	5	int:EGR2
Interaction	ACTN2 interactions	ACTN4 MYH8 ACTN1 ACTN2 SSX2IP	3.08e-05	171	43	5	int:ACTN2
Interaction	FEV interactions	KDM2B GTF3C1 PHF10 CXXC1 ZMYM4	6.96e-05	203	43	5	int:FEV
Interaction	TPM2 interactions	ACTN4 ACTN1 ACTN2 CFAP97D1 RHOBTB2	7.99e-05	209	43	5	int:TPM2
Interaction	MYOZ1 interactions	ACTN4 ACTN1 ACTN2	1.37e-04	47	43	3	int:MYOZ1
GeneFamily	Actinins	ACTN4 ACTN1 ACTN2	2.01e-08	4	32	3	1112
GeneFamily	PHD finger proteins	KDM2B PHF20L1 PHF10 CXXC1	1.86e-05	90	32	4	88
GeneFamily	Zinc fingers CXXC-type	KDM2B CXXC1	1.98e-04	12	32	2	136
GeneFamily	Sterile alpha motif domain containing	PPFIA3 ARAP2	1.06e-02	88	32	2	760
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACTN1 CACNA2D3 ARAP2 SSX2IP PPM1L	1.05e-06	189	43	5	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	KDM2B ECM2 TMCC2 ARAP2	2.16e-05	170	43	4	513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 TMCC2 SSX2IP TPX2	3.14e-05	187	43	4	69068480f6819a6c8560ecbb05deb156b4055e12
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 TMCC2 SSX2IP TPX2	3.14e-05	187	43	4	9c8b932a15b8b50982cba4cf8db750e257eb9503
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 TMCC2 SSX2IP TPX2	3.14e-05	187	43	4	46e15419e80bd7180f3171a99d845b01bb635e53
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 ACTN4 ACTN1 CACNA2D3	3.14e-05	187	43	4	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ACSL4 PHF10 MTOR TMCC2	3.14e-05	187	43	4	c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 TMCC2 SSX2IP TPX2	3.14e-05	187	43	4	0d17b07770e4c881a7ca53a5bd42471457d198fb
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	KCNMB2 ACTN4 ACTN1 ACTN2	3.21e-05	188	43	4	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic\|lymph-node_spleen / Manually curated celltypes from each tissue	TEX15 CFAP97D1 CACNA2D3 TPX2	3.21e-05	188	43	4	723348a1836a074e068320cb736ce6a953e0038f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACTN1 CACNA2D3 ARAP2 PPM1L	3.27e-05	189	43	4	a75226616340045b581d08429d2e123e041dee55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 ACTN4 ACTN1 CACNA2D3	3.27e-05	189	43	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ACTN4 ACTN2 XIRP2 PPM1L	3.27e-05	189	43	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	KCNMB2 CILP XIRP2 ECM2	3.34e-05	190	43	4	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACTN1 CACNA2D3 ARAP2 PPM1L	3.34e-05	190	43	4	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACTN1 CACNA2D3 ARAP2 PPM1L	3.34e-05	190	43	4	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRG3 ACTN1 SOX8 CILP	3.70e-05	195	43	4	1be9502577267ca2a04656a99d57e3e2f124d92e
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_NK-NK_CD16\|lymph-node_spleen / Manually curated celltypes from each tissue	ACTN4 GTF3C1 BHLHE40 PPM1L	3.77e-05	196	43	4	f7e5a7fad4547e8ab9ab8b140239281832fb4260
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	GTF3C1 BHLHE40 ARAP2 PPM1L	3.93e-05	198	43	4	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	COVID-19_Mild-NK\|COVID-19_Mild / Disease condition and Cell class	ACTN4 GTF3C1 BHLHE40 PPM1L	4.08e-05	200	43	4	b586b0f1127293c2f8529be16b24229359041da2
ToppCell	COVID-19-COVID-19_Mild-Others-Platelet\|COVID-19_Mild / Disease, condition lineage and cell class	ACTN1 XIRP2 TMCC2 SSX2IP	4.08e-05	200	43	4	bf5e7a36d6ed44a30f906702b40ace3ecd423398
ToppCell	Bronchial-10x5prime-Hematologic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBXO7 TMCC2 TPX2	2.44e-04	126	43	3	b6482ef18e6d9e12ba4810ce7845f9f991cb95bc
ToppCell	Bronchial-10x5prime-Hematologic-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBXO7 TMCC2 TPX2	2.44e-04	126	43	3	65c7c0e4cfb5ac58d80b4034d42e9f662116e0d3
ToppCell	Bronchial-10x5prime-Hematologic-Erythrocyte-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBXO7 TMCC2 TPX2	2.44e-04	126	43	3	12f3d0f60db462f2a9799b3a06005bc871670760
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAP7 CFAP97D1 CACNA2D3	2.67e-04	130	43	3	6434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	GABRG3 ACTN2 XIRP2	2.67e-04	130	43	3	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX15 PHF10 TPX2	3.05e-04	136	43	3	a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX15 PHF10 TPX2	3.12e-04	137	43	3	8e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell	Pericytes-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CCDC191 ECM2 TPX2	4.06e-04	150	43	3	dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACTN4 BHLHE40 ARAP2	4.14e-04	151	43	3	b545823113a3450c5f841f7de48bf0937593544f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACTN4 BHLHE40 ARAP2	4.14e-04	151	43	3	0cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCell	Lung_Parenchyma-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMCC2 SSX2IP PPM1L	4.23e-04	152	43	3	71d5061aee7f744b2db3c3892d15c6919d07c0be
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC-RBC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMCC2 SSX2IP PPM1L	4.23e-04	152	43	3	98cdcf18daeb728974ab133b365b7352b08558a8
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Erythrocytes\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TMCC2 SSX2IP PPM1L	4.23e-04	152	43	3	bf07aafe2f36eda3a9cda93083ca7a081498e36e
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC-RBC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMCC2 SSX2IP PPM1L	4.23e-04	152	43	3	27f25c1e22a81fbdd6c39ca47eeb310939211362
ToppCell	Lung_Parenchyma-Control-Hematopoietic-RBC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMCC2 SSX2IP PPM1L	4.23e-04	152	43	3	df87b8333e3f54fab0d8b1e8690f1a36bcb7e9e3
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	GTF3C1 CCDC149	4.35e-04	32	43	2	ba89b22a5ce8ee9f3099b1fa84721724b94c7759
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	GTF3C1 CCDC149	4.35e-04	32	43	2	58b212d4f2955f06a195df0f79ad95a8ff145b83
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KCNMB2 ZNF607 ECM2	4.56e-04	156	43	3	a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PPFIA3 BHLHE40 PHF10	4.82e-04	159	43	3	f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PPFIA3 BHLHE40 PHF10	4.82e-04	159	43	3	929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|368C / Donor, Lineage, Cell class and subclass (all cells)	KDM2B CFAP97D1 ARAP2	4.91e-04	160	43	3	bcd90ef96464bd901b87b94c696de70c113bfd03
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACTN4 BHLHE40 ECM2	5.00e-04	161	43	3	bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	CFAP97D1 CACNA2D3 TPX2	5.27e-04	164	43	3	0662cd9d21608efacc336e0a582859f3b9a4951d
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRG3 DLG5 XIRP2	5.27e-04	164	43	3	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	facs-Heart-LA-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 XIRP2 CACNA2D3	5.37e-04	165	43	3	95866f7cc6eb1bb51a034a104a0eb2a53b0256f2
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FANCB TMCC2 TPX2	5.37e-04	165	43	3	a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCell	facs-Heart-LA-18m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 XIRP2 CACNA2D3	5.37e-04	165	43	3	f8bfe336b9a4460b9349c01acd0bd3167812662f
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN1 TEX15 TMCC2	5.37e-04	165	43	3	9acf03b5a20170721380045b5c268825e8f315dd
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH8 ACTN2 XIRP2	5.56e-04	167	43	3	d78356bf0c473816dbabaee51984940bd822f84e
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF486 SSX2IP PPM1L	5.56e-04	167	43	3	e242827999caad08b0894d88ab97bc1df41b7650
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	XIRP2 TMCC2 SSX2IP	5.66e-04	168	43	3	2f69e248c6fab1421c0081e01e1920e6ffcde344
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	XIRP2 TMCC2 SSX2IP	5.66e-04	168	43	3	2d056cfbb470a088a0682576753535fb4528d48f
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KDM2B ECM2 TMCC2	5.75e-04	169	43	3	44d201361eb497222a4972a0e10bac1e05dcfd0a
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 MAP7	5.85e-04	170	43	3	4ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCB CCDC191 ITSN1	5.95e-04	171	43	3	23b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP7 CILP ITSN1	6.06e-04	172	43	3	5401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP7 CILP ITSN1	6.06e-04	172	43	3	b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCell	wk_15-18-Hematologic-Myeloid-Mast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ACSL4 CFAP97D1 BHLHE40	6.06e-04	172	43	3	a7146c255031207e64682ef767884b11c96e0d59
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP7 CILP ITSN1	6.06e-04	172	43	3	74dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACTN1 ACTN2 CACNA2D3	6.16e-04	173	43	3	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDM2B TMCC2 ARAP2	6.16e-04	173	43	3	94f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-ILC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ZNF486 MAP7 BHLHE40	6.26e-04	174	43	3	7c50bf9da37711266cc077eef4e54b58463f1d37
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPFIA3 CACNA2D3 TPX2	6.26e-04	174	43	3	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACTN4 GTF3C1 BHLHE40	6.37e-04	175	43	3	8fb8c4b9e2d9b7d737f59cd9bd3dc2bca5a8dfc4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACTN4 RHOBTB2 ARAP2	6.37e-04	175	43	3	0c6cf88818037bef67211c1a8fcb1e7d47711c1d
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 BHLHE40 ARAP2	6.47e-04	176	43	3	e2b4be7d4f31a78d7862c0fd629dd9cc84589193
ToppCell	wk_20-22-Hematologic-Meg-ery-Cycling_definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FBXO7 TMCC2 TPX2	6.47e-04	176	43	3	98814f0a67411b2f7b25dc489b2aadb77f45a853
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN2 BHLHE40 ARAP2	6.47e-04	176	43	3	299075e65ca86564e1c0b06058bd4371a60a3bcd
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 TPX2	6.58e-04	177	43	3	a68c3688f12aee22f3cb4049c4bccacbacb0fae6
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 TPX2	6.58e-04	177	43	3	3081ce5fc66a1bb833719d6c0e0a6fc7115eeb91
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KDM2B TMCC2 ARAP2	6.58e-04	177	43	3	a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERCC6 BHLHE40 TMCC2	6.58e-04	177	43	3	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLG5 ACTN2 BHLHE40	6.69e-04	178	43	3	408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMB2 CILP ECM2	6.80e-04	179	43	3	dcd0a83f0592ae27f814d064b4791f84c3c86e64
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	6.80e-04	179	43	3	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	6.80e-04	179	43	3	7db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	6.91e-04	180	43	3	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-T_mait\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 BHLHE40 ARAP2	6.91e-04	180	43	3	e53e9f3ebd48fb8237515e740ba5d9880ed6ade3
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-T_mait-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 BHLHE40 ARAP2	6.91e-04	180	43	3	9d18aa1044945fe6481ea3284037a777657fd837
ToppCell	facs-Lung-EPCAM-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCB XIRP2 TMCC2	6.91e-04	180	43	3	082c6116e0bbba8d9a3a82d14af55bdc8990c8c0
ToppCell	facs-Lung-EPCAM-18m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCB XIRP2 TMCC2	6.91e-04	180	43	3	53043d764fad9ac33ee40e356e562e759931adef
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTN2 BHLHE40 ARAP2	7.02e-04	181	43	3	a2c03bd7adc4a65f3b373c229ec0ecc84f724b17
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACSL4 ACTN2 ZNF607	7.02e-04	181	43	3	338c7362d258a87f1a6b1a65376f5394d4b2b4b2
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-mature_NK_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTN2 BHLHE40 ARAP2	7.02e-04	181	43	3	c073e6c917354528ac5bad88a226e1134004ba43
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG3 ACTN2 CACNA2D3	7.13e-04	182	43	3	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FBXO7 TMCC2 SSX2IP	7.13e-04	182	43	3	a99d48084aa6f5c34f4a622ae6c2165db7f0beff
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG3 ACTN2 CACNA2D3	7.13e-04	182	43	3	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	7.13e-04	182	43	3	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	droplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX8 ECM2 PPM1L	7.25e-04	183	43	3	19e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	GTF3C1 BHLHE40 ARAP2	7.25e-04	183	43	3	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	droplet-Lung-nan-21m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX8 ECM2 PPM1L	7.25e-04	183	43	3	b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACTN2 CILP TMCC2	7.25e-04	183	43	3	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(I)\|lymph-node_spleen / Manually curated celltypes from each tissue	TEX15 MAP7 TPX2	7.36e-04	184	43	3	057c6c2f570914fa4af84682589a86b61547d6c9
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	7.36e-04	184	43	3	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	7.36e-04	184	43	3	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACSL4 MAP7 CACNA2D3	7.36e-04	184	43	3	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL4 CACNA2D3 PPM1L	7.36e-04	184	43	3	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC74B CILP CACNA2D3	7.48e-04	185	43	3	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX8 CILP ECM2	7.48e-04	185	43	3	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
Drug	conen	ACTN4 ACTN1 ACTN2	2.81e-06	15	43	3	CID000093117
Drug	Omeprazole [73590-58-6]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ACTN2 ERCC6 PPFIA3 BHLHE40 CXXC1	3.16e-05	194	43	5	2828_UP
Drug	Oxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT_HG-U133A	DLG5 ACTN4 PHF20L1 MTOR SSX2IP	3.24e-05	195	43	5	7225_DN
Drug	Oxybutynin chloride [1508-65-2]; Down 200; 10.2uM; HL60; HG-U133A	ACTN1 ACTN2 BHLHE40 ZMYM4 SSX2IP	3.40e-05	197	43	5	1551_DN
Drug	Carbinoxamine maleate salt [3505-38-2]; Up 200; 9.8uM; HL60; HT_HG-U133A	DLG5 ACTN2 TEX15 CILP TMCC2	3.48e-05	198	43	5	2725_UP
Drug	Fenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A	PPFIA3 CXXC1 MTOR ITSN1 ARAP2	3.48e-05	198	43	5	7474_DN
Drug	Metformin hydrochloride [1115-70-4]; Down 200; 24.2uM; MCF7; HT_HG-U133A	DLG5 ACTN2 MTOR ZMYM4 SSX2IP	3.48e-05	198	43	5	5487_DN
Drug	Cinoxacin [28657-80-9]; Up 200; 15.2uM; PC3; HT_HG-U133A	KCNMB2 GABRG3 TEX15 MAP7 CACNA2D3	3.56e-05	199	43	5	5783_UP
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN1 ACTN2	2.49e-08	5	41	3	DOID:0111128 (implicated_via_orthology)
Disease	endometrial neoplasm	ZMYM4 CACNA2D3	1.03e-04	11	41	2	EFO_0004230
Disease	mean reticulocyte volume	FBXO7 GTF3C1 PHF20L1 MTOR ITSN1 TMCC2 TPX2	1.05e-04	799	41	7	EFO_0010701
Disease	Peripheral Nervous System Diseases	SOX8 RHOBTB2	2.58e-03	54	41	2	C4721453

Protein segments in the cluster

Peptide	Gene	Start	Entry
LKRKELRNHYLKDIE	ACSL4	691	O60488
QKLEDFRDYRRLHKP	ACTN1	311	P12814
EDFRDYRRKHKPPKV	ACTN2	321	P35609
KEREYNKLKERLHQL	SSX2IP	201	Q9Y2D8
ETYKLPHRLIEKKRR	BHLHE40	51	O14503
RDYRRVHKPPKVQEK	ACTN4	336	O43707
LEHKDDKLRNRPRKH	ARAP2	1616	Q8WZ64
EHLKRENKDLRYKLI	CCDC74B	76	Q96LY2
RIPHLVKKRRYQKQD	ERCC6	1221	Q03468
PRAQKIAEHRRKYER	ST13	226	P50502
IYQKIRDHDLLDKRK	KCNMB2	21	Q9Y691
RQHYEKHLEERKKRL	MAP7	96	Q14244
PGDKDRRNKRKHELL	PPFIA3	811	O75145
KGLRKHERRVKELTY	MYH8	1841	P13535
KHIKEQRDPIYLRDK	DLG5	1846	Q8TDM6
RENIHPYRKELQREK	FANCB	806	Q8NB91
KYPDLERRDLSHKEK	PHF10	106	Q8WUB8
KDPKLEIRYRHKKSR	CXXC1	76	Q9P0U4
DDVHLRKKRKYEKPQ	KDM2B	796	Q8NHM5
RERHQSLKKKYRELI	CCDC149	6	Q6ZUS6
LNKLLREYDKKLRPD	GABRG3	51	Q99928
HPELRLLYEEGKKRR	CACNA2D3	536	Q8IZS8
YRKRHIQRKESPKGR	FBXO7	396	Q9Y3I1
QRPRKLHEEEKLKRE	ITSN1	671	Q15811
KEHYERVLLRKKGLE	CCDC191	741	Q8NCU4
LKRLVDRKPHYDRRA	CFAP97D1	126	B2RV13
KNEEIPRKQRRKIYH	ECM2	21	O94769
RHRIDLKLNKKPRAD	MEAF6	176	Q9HAF1
REKRDKDHYRPKQKK	PHF20L1	556	A8MW92
RDYREKKKILLNIEH	MTOR	2251	P42345
HKKLEHYRRRLKEIE	TMCC2	351	O75069
EKEDYLHLKRQPKRR	RHOBTB2	686	Q9BYZ6
HKPYQLKERKRIKRA	PPM1L	231	Q5SGD2
QLPVGKKEVEHYRKR	FTSJ3	716	Q8IY81
ERLRVQHKKDHPDYK	SOX8	156	P57073
KLNYRRTDHEDPRVK	CILP	856	O75339
LAERHYQLPKKEKRV	XIRP2	2591	A4UGR9
DLRKHQKINAREKPY	ZNF607	156	Q96SK3
PHKDLRRHKIYGRKR	TEX15	931	Q9BXT5
DKPHETYRLLKRRNL	GTF3C1	606	Q12789
RHKRRHTEKKPLKYI	ZNF486	171	Q96H40
TYEREKRLDKPHKDL	ZMYM4	176	Q5VZL5
KRTPNRYHLRSKKDD	TPX2	336	Q9ULW0