Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	LHX2 FOXN2 ZNF182 TBX4 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF723 ZNF236 SP110 HES5 ZNF433 ZNF441 ZNF284 LHX9 ZNF114	2.67e-05	1412	94	19	GO:0000981
GeneOntologyMolecularFunction	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	PRKCE PRKCH	6.56e-05	3	94	2	GO:0004699
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	LHX2 NCOR1 ZNF182 TBX4 FEZF1 ZNF652 PLAGL1 ZNF561 ZNF420 ZNF723 ZNF236 HES5 ZNF433 ZNF441 ZNF284 ZNF710 LHX9 ZNF114	1.37e-04	1459	94	18	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	LHX2 FOXN2 ZNF182 TBX4 FEZF1 ZNF652 PLAGL1 ZNF561 ZNF420 ZNF723 ZNF236 HES5 ZNF433 ZNF284 ZNF710 ZNF114	2.72e-04	1271	94	16	GO:0000987
Domain	zf-C2H2_6	ZNF182 FEZF1 ZNF652 ZBTB47 ZNF561 ZNF420 ZNF236 ZNF433 ZNF284 ZNF710 ZNF114	4.08e-07	314	92	11	PF13912
Domain	Smg8/Smg9	SMG8 SMG9	2.40e-05	2	92	2	IPR019354
Domain	Smg8_Smg9	SMG8 SMG9	2.40e-05	2	92	2	PF10220
Domain	-	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	2.74e-05	679	92	13	3.30.160.60
Domain	zf-C2H2	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	3.39e-05	693	92	13	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	3.44e-05	694	92	13	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	1.06e-04	775	92	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	1.08e-04	777	92	13	PS00028
Domain	Znf_C2H2-like	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	1.38e-04	796	92	13	IPR015880
Domain	Prot_kin_PKC_delta	PRKCE PRKCH	1.43e-04	4	92	2	IPR014376
Domain	Znf_C2H2	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	1.54e-04	805	92	13	IPR007087
Domain	ZnF_C2H2	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	1.60e-04	808	92	13	SM00355
Pubmed	Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCδ during Plasticity.	NTRK2 PRKCE PRKCH	7.63e-08	4	94	3	37277178
Pubmed	Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.	SMG8 SMG9	7.23e-06	2	94	2	20817927
Pubmed	Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex.	LHX2 LHX9	7.23e-06	2	94	2	10330499
Pubmed	LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene.	LHX2 CYP19A1	7.23e-06	2	94	2	22734700
Pubmed	Expanding the phenotypic and allelic spectrum of SMG8: Clinical observations reveal overlap with SMG9-associated disease trait.	SMG8 SMG9	7.23e-06	2	94	2	34761517
Pubmed	Structure of human Roquin-2 and its complex with constitutive-decay element RNA.	RC3H2 RC3H1	7.23e-06	2	94	2	26249698
Pubmed	Fgf15 regulates thalamic development by controlling the expression of proneural genes.	LHX2 HES5 LHX9	1.80e-05	19	94	3	26311466
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FAT1 CLTCL1 ZNF652 NTRK2 TTLL11 CAPNS1 RCOR3 SAMHD1 LYST	1.93e-05	552	94	9	10737800
Pubmed	Cryo-EM structure of SMG1-SMG8-SMG9 complex.	SMG8 SMG9	2.16e-05	3	94	2	31729466
Pubmed	InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.	SMG8 SMG9	2.16e-05	3	94	2	31792449
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 RC3H1	2.16e-05	3	94	2	23583642
Pubmed	Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.	RC3H2 RC3H1	2.16e-05	3	94	2	28188245
Pubmed	A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.	PRKCE PRKCH	2.16e-05	3	94	2	2266135
Pubmed	BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.	NTRK2 BBS4	2.16e-05	3	94	2	24867303
Pubmed	Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.	KL SAMHD1	2.16e-05	3	94	2	37213666
Pubmed	Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.	RC3H2 RC3H1	2.16e-05	3	94	2	25026077
Pubmed	Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.	RC3H2 RC3H1	2.16e-05	3	94	2	30232334
Pubmed	Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.	SMG8 SMG9	2.16e-05	3	94	2	32469312
Pubmed	Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival.	PRKCE PRKCH	2.16e-05	3	94	2	23562764
Pubmed	A census of human transcription factors: function, expression and evolution.	LHX2 RC3H2 FOXN2 ZNF182 TBX4 PLAGL1 RCOR3 ZNF236 SP110 HES5 LHX9	3.47e-05	908	94	11	19274049
Pubmed	Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system.	LHX2 LHX9	4.32e-05	4	94	2	12351192
Pubmed	Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.	RC3H2 RC3H1	4.32e-05	4	94	2	25697406
Pubmed	Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.	PRKCE PRKCH	4.32e-05	4	94	2	8670164
Pubmed	A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.	PRKCE PRKCH	4.32e-05	4	94	2	21602810
Pubmed	Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.	LHX2 LHX9	4.32e-05	4	94	2	21690374
Pubmed	TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang II-induced vascular remodeling.	ANO1 MYOCD	4.32e-05	4	94	2	26077572
Pubmed	Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates.	LHX2 LHX9	4.32e-05	4	94	2	35247020
Pubmed	Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKC beta and zeta in concert with upregulation of PKC epsilon.	PRKCE PRKCH	4.32e-05	4	94	2	12648500
Pubmed	Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain.	LHX2 LHX9	4.32e-05	4	94	2	9880598
Pubmed	A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.	RC3H2 RC3H1	4.32e-05	4	94	2	31636267
Pubmed	Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.	PRKCE PRKCH	4.32e-05	4	94	2	34593629
Pubmed	Family-based analysis of candidate genes for polycystic ovary syndrome.	INHBA CYP19A1 CAPN5	5.34e-05	27	94	3	20200332
Pubmed	Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes.	LHX2 LHX9	7.19e-05	5	94	2	20599893
Pubmed	Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon).	PRKCE PRKCH	7.19e-05	5	94	2	12223477
Pubmed	Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.	LHX2 LHX9	7.19e-05	5	94	2	19923199
Pubmed	Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.	RC3H2 RC3H1	7.19e-05	5	94	2	27010430
Pubmed	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.	SMG8 SMG9	7.19e-05	5	94	2	26841701
Pubmed	Protein kinase C isoform expression and activity in the mouse heart.	PRKCE PRKCH	1.08e-04	6	94	2	11668067
Pubmed	BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions.	LHX2 LHX9	1.08e-04	6	94	2	18272594
Pubmed	Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.	PRKCE PRKCH	1.08e-04	6	94	2	8621384
Pubmed	Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.	PRKCE PRKCH	1.08e-04	6	94	2	15632189
Pubmed	Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.	PRKCE PRKCH	1.08e-04	6	94	2	22732145
Pubmed	Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.	SMG8 SMG9	1.08e-04	6	94	2	33205750
Pubmed	Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.	RC3H2 RC3H1	1.08e-04	6	94	2	34471108
Pubmed	Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase.	PRKCE PRKCH	1.08e-04	6	94	2	12783114
Pubmed	Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.	LHX2 LHX9	1.50e-04	7	94	2	23136391
Pubmed	Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.	RC3H2 RC3H1	1.50e-04	7	94	2	34811541
Pubmed	The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.	LHX2 LHX9	1.50e-04	7	94	2	10693804
Pubmed	Progenitors of dorsal commissural interneurons are defined by MATH1 expression.	LHX2 LHX9	1.50e-04	7	94	2	9449674
Pubmed	GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.	LHX2 LHX9	1.50e-04	7	94	2	18577233
Pubmed	Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer.	NTRK2 GRIA3	1.50e-04	7	94	2	10407040
Pubmed	Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9.	CYP19A1 BBS4	1.50e-04	7	94	2	19640321
Pubmed	Congenital Insensitivity to Pain Overview	CLTCL1 SCN9A	1.50e-04	7	94	2	29419974
Pubmed	Neuronal activity regulates alternative exon usage.	RCAN1 INHBA	1.50e-04	7	94	2	33172478
Pubmed	Structure and physiological function of calpains.	CAPNS1 CAPN5	1.50e-04	7	94	2	9396712
Pubmed	Transcriptional network orchestrating regional patterning of cortical progenitors.	LHX2 PLAGL1 HES5	1.63e-04	39	94	3	34921112
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	RC3H2 GLT6D1 STRN GALNT11 RC3H1 PRKCE PRKCH CAPN5 SEC23B	1.64e-04	730	94	9	34857952
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 NCOR1 FAT1 CLTCL1 TRIB3 PI4KA KHNYN PIGW BAMBI ZNF236 LYST	1.97e-04	1105	94	11	35748872
Pubmed	Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.	PRKCE PRKCH	2.00e-04	8	94	2	7606770
Pubmed	A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.	LHX2 LHX9	2.00e-04	8	94	2	12741987
Pubmed	Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.	RC3H2 RC3H1	2.00e-04	8	94	2	29246441
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPNS1 CAPN5	2.00e-04	8	94	2	9473662
Pubmed	Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.	RC3H2 RC3H1	2.00e-04	8	94	2	29352114
Pubmed	Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.	TTLL6 TTLL11	2.00e-04	8	94	2	20530212
Pubmed	Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.	PARP1 CAPNS1	2.00e-04	8	94	2	17470554
Pubmed	Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.	RC3H2 RC3H1	2.00e-04	8	94	2	25282160
Pubmed	Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity.	LHX2 LHX9	2.00e-04	8	94	2	23250207
Pubmed	A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.	LHX2 LHX9	2.00e-04	8	94	2	18701067
Pubmed	Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.	PRKCE PRKCH	2.57e-04	9	94	2	7876252
Pubmed	Sak kinase gene structure and transcriptional regulation.	INHBA LYST	2.57e-04	9	94	2	10607900
Pubmed	Phosphorylation of HIV-1 gag proteins by protein kinase C.	PRKCE PRKCH	2.57e-04	9	94	2	8473314
Pubmed	Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes.	PRKCE PRKCH	2.57e-04	9	94	2	11700305
Pubmed	EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors.	LHX2 LHX9	2.57e-04	9	94	2	15294144
Pubmed	aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.	PRKCE PRKCH	2.57e-04	9	94	2	17203073
Pubmed	Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.	PRKCE PRKCH	2.57e-04	9	94	2	7850771
Pubmed	Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.	PRKCE PRKCH	2.57e-04	9	94	2	8206685
Pubmed	Molecular markers of neuronal progenitors in the embryonic cerebellar anlage.	LHX2 LHX9	2.57e-04	9	94	2	17122047
Pubmed	Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex.	LHX2 LHX9	2.57e-04	9	94	2	15758185
Pubmed	Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem.	LHX2 LHX9	2.57e-04	9	94	2	20498066
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	PARP1 IPO9 LHX9	2.67e-04	46	94	3	30419336
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	NCOR1 RPL27A PARP1 FAT1 ZNF652 SAMHD1	2.91e-04	332	94	6	29053956
Pubmed	Comparative mapping in the beige-satin region of mouse chromosome 13.	INHBA LYST	3.21e-04	10	94	2	9027500
Pubmed	The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.	PRKCE PRKCH	3.21e-04	10	94	2	1970444
Pubmed	The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.	LHX2 LHX9	3.21e-04	10	94	2	30843071
Pubmed	Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.	LHX2 LHX9	3.21e-04	10	94	2	11502254
Pubmed	Human immunodeficiency virus induces phosphorylation of its cell surface receptor.	PRKCE PRKCH	3.21e-04	10	94	2	3259291
Pubmed	A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci.	INHBA LYST	3.21e-04	10	94	2	2307475
Pubmed	Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.	PRKCE PRKCH	3.21e-04	10	94	2	10491200
Pubmed	Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.	PRKCE PRKCH	3.21e-04	10	94	2	2139676
Pubmed	Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.	LHX2 LHX9	3.21e-04	10	94	2	15183721
Pubmed	Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.	PRKCE PRKCH	3.91e-04	11	94	2	14613966
Pubmed	Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.	RC3H2 RC3H1	3.91e-04	11	94	2	23583643
Pubmed	IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.	PRKCE PRKCH	3.91e-04	11	94	2	8599832
Pubmed	Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.	PRKCE PRKCH	3.91e-04	11	94	2	2182321
Pubmed	Identification of new high affinity targets for Roquin based on structural conservation.	RC3H2 RC3H1	3.91e-04	11	94	2	30295819
Pubmed	BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.	LHX2 LHX9	3.91e-04	11	94	2	22609550
Pubmed	In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.	PRKCE PRKCH	3.91e-04	11	94	2	8914829
Pubmed	Expression profile of protein kinase C isozymes in preimplantation mouse development.	PRKCE PRKCH	3.91e-04	11	94	2	16183862
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PCNX2 NCOR1 FEZF1 SCN9A ANKIB1	4.37e-04	233	94	5	37704626
Pubmed	HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.	PRKCE PRKCH	4.69e-04	12	94	2	11919157
Cytoband	19p13.2	S1PR2 ZNF561 ZNF433 ZNF441	1.29e-03	229	94	4	19p13.2
Cytoband	1q32.2	PTPN14 RCOR3	1.41e-03	27	94	2	1q32.2
Cytoband	19q13.31	SMG9 ZNF284	1.62e-03	29	94	2	19q13.31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF182 FEZF1 ZNF652 ZBTB47 PLAGL1 ZNF561 ZNF420 ZNF236 ZNF433 ZNF441 ZNF284 ZNF710 ZNF114	3.80e-06	718	71	13	28
GeneFamily	C2 domain containing protein kinases	PRKCE PRKCH	6.70e-04	10	71	2	835
GeneFamily	LIM class homeoboxes	LHX2 LHX9	9.78e-04	12	71	2	522
GeneFamily	Tubulin tyrosine ligase family	TTLL6 TTLL11	1.34e-03	14	71	2	779
Drug	Citalopram	PARP1 NTRK2 CYP19A1 GRIA3 CAT	5.99e-07	40	93	5	ctd:D015283
Disease	polycystic ovary syndrome (implicated_via_orthology)	NCOR1 CYP19A1	1.40e-04	6	91	2	DOID:11612 (implicated_via_orthology)
Disease	Alcohol Related Birth Defect	NTRK2 CAT	1.40e-04	6	91	2	C3146244
Disease	Congenital Pain Insensitivity	CLTCL1 SCN9A	1.96e-04	7	91	2	C0002768
Disease	morbid obesity (is_implicated_in)	NTRK2 BBS4	2.60e-04	8	91	2	DOID:11981 (is_implicated_in)
Disease	primary ovarian insufficiency	PRKCE RBM46	3.34e-04	9	91	2	EFO_0004266
Disease	corpus callosum posterior volume measurement	STRN GAL3ST1 PRKCE	5.62e-04	52	91	3	EFO_0010298
Disease	vascular endothelial growth factor measurement	PRKCH PTGR3 ZNF710	6.99e-04	56	91	3	EFO_0004762
Disease	Cardiomyopathies	PARP1 PRKCE CAT MYOCD	7.15e-04	130	91	4	C0878544
Disease	Alzheimer's disease (is_implicated_in)	PARP1 RCAN1 NTRK2 CYP19A1	7.57e-04	132	91	4	DOID:10652 (is_implicated_in)
Disease	Hepatitis	PARP1 CAT	9.62e-04	15	91	2	C0019158
Disease	susceptibility to vaginal yeast infection measurement	SULF1 NTRK2 AMMECR1	1.08e-03	65	91	3	EFO_0008412
Disease	Cardiomyopathies, Primary	PARP1 PRKCE CAT	1.28e-03	69	91	3	C0033141
Disease	Myocardial Diseases, Secondary	PARP1 PRKCE CAT	1.28e-03	69	91	3	C0036529
Disease	Non-alcoholic Fatty Liver Disease	TRIB3 PRKCE CAT	1.34e-03	70	91	3	C0400966
Disease	Nonalcoholic Steatohepatitis	TRIB3 PRKCE CAT	1.34e-03	70	91	3	C3241937
Disease	androstenedione measurement, estrone measurement	RPUSD4 CYP19A1	1.39e-03	18	91	2	EFO_0007970, EFO_0007972
Disease	nucleotide measurement	SULF1 PRKCE RBM46	1.51e-03	73	91	3	EFO_0010513
Disease	alcohol consumption measurement	RC3H2 FOXN2 IPO9 RCAN1 TTLL6 NTRK2 RCOR3 ZNF420 SAMHD1 ST8SIA3 SEC23B	1.53e-03	1242	91	11	EFO_0007878
Disease	body weight	NCOR1 RPUSD4 PTPN14 TBX4 IPO9 FEZF1 NTRK2 CYP19A1 ANO1 PRKCE TEX10	1.72e-03	1261	91	11	EFO_0004338
Disease	polycystic ovary syndrome (biomarker_via_orthology)	NCOR1 CYP19A1	1.90e-03	21	91	2	DOID:11612 (biomarker_via_orthology)
Disease	intrinsic cardiomyopathy (implicated_via_orthology)	RPL27A MRPS2	1.90e-03	21	91	2	DOID:0060036 (implicated_via_orthology)
Disease	hypothyroidism (biomarker_via_orthology)	NCOR1 CYP19A1 CAT	1.96e-03	80	91	3	DOID:1459 (biomarker_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	NCOR1 SCN9A	2.09e-03	22	91	2	DOID:2030 (implicated_via_orthology)
Disease	idiopathic pulmonary fibrosis (is_marker_for)	PARP1 NTRK2	2.28e-03	23	91	2	DOID:0050156 (is_marker_for)
Disease	corpus collosum mid-posterior volume measurement	STRN GAL3ST1	2.69e-03	25	91	2	EFO_0010300

Protein segments in the cluster

Peptide	Gene	Start	Entry
GMNYLSNHNYVHRDL	EPHA1	736	P21709
GLVHLTMQQYASAFH	BBS4	311	Q96RK4
HMNGYGSHTFKLVNA	CAT	211	P04040
HYAARHGMNKILGTF	ANKIB1	51	Q9P2G1
QYRMHSLQHKAASSI	CAPN5	436	O15484
LSFHSTVINHYRMRG	INHBA	366	P08476
MLLHRVAAYFGLDHN	R3HDM1	201	Q15032
SSLLYGDLAHKSHMQ	RC3H2	301	Q9HBD1
LLYGDQSHKSHMQSI	RC3H1	306	Q5TC82
MKLYFAQTLHIGSSH	RCAN1	136	P53805
FSFHGKSFHRIQQML	RCOR3	101	Q9P2K3
LKSNHFNSAVMHLDY	RBM46	386	Q8TBY0
LGNMYELKHASHISK	PARP1	926	P09874
RGISYQMFGNHSKSH	FAT1	2316	Q14517
RLDTHLHNPMYNFIS	OR6K3	66	Q8NGY3
QYAGLLHHLTMKAKS	DYNLRB2	41	Q8TF09
MHGSQLTQRYLEKHG	KDM7A	141	Q6ZMT4
HFKNMKTNGSHYFLN	PNLIPRP3	331	Q17RR3
RFSVNMPHKFGIHNY	PRKCE	236	Q02156
LGKHSRGYHYMLANL	GRIA3	236	P42263
HNMAISLDSFLYGLH	PCNX2	1646	A6NKB5
HHQLRTMKSYFAINH	LHX9	276	Q9NQ69
KHAFNMLISDRLGYH	GALNT11	116	Q8NCW6
LDRSHPQHYTQAMFK	PI4KA	1181	P42356
TSFKHHQLRTMKSYF	LHX2	271	P50458
HQLRTMKSYFAINHN	LHX2	276	P50458
KSYLMNHLAGQNHGF	GBP6	51	Q6ZN66
YSKNGTMHGFVNHTL	ANO1	821	Q5XXA6
HRFSYLGMHQAQLKE	MYOCD	311	Q8IZQ8
NMLDSHLYRHFNASF	GAL3ST1	301	Q99999
SNKHIHFEYNMSLFL	COG1	461	Q8WTW3
QRQQMLSRLHYSFHG	BAMBI	186	Q13145
IMKHNHYSSRFGSKL	CYP19A1	106	P11511
LHSANKHFMTGYRVI	GLT6D1	96	Q7Z4J2
NLKAMATSHFHFNLR	COL6A5	176	A8TX70
AGFHLNEHLYNMIIR	CAPNS1	201	P04632
RGQHFHGQNMTIFYK	HYAL3	61	O43820
FLYRTGQHSNKFMLI	ATAD3C	261	Q5T2N8
GHPQALRVHSYKSMQ	DRC7	506	Q8IY82
HYSNSGTVLHFLVRM	LYST	3236	Q99698
VFQRSNKMHALNGYL	HEPHL1	261	Q6MZM0
SHKLYSQLLHTQMFS	DENND4B	616	O75064
TALQKKRSYGNAFHH	FOXN2	266	P32314
KNGRIHFDMHGFLTN	IPO9	466	Q96P70
YTRNMTYSAGHNLLK	KL	691	Q9UEF7
NVAMVHGLQHYFSSR	KHNYN	446	O15037
YSQHLRFSTHQMKDP	CCDC168	2001	Q8NDH2
SSSSQYKANMHFHKL	GRAMD2B	101	Q96HH9
NSKFHSAMYLFLGNL	S1PR2	61	O95136
CHSLGYNFIHKMNTA	RALGPS2	341	Q86X27
VGMKHYHLKRNQSFC	RPL27A	56	P46776
SQHARGPAFHKYAMQ	SMG8	536	Q8ND04
GQQQHHKMTLSPSYR	RPUSD4	211	Q96CM3
YDNNTGKLIHSMVAH	STRN	691	O43815
NTMLGYKRHLALHAA	PLAGL1	101	Q9UM63
VGNLYDMFHTRNSLH	SAMHD1	356	Q9Y3Z3
GKVFNAHYNLTRHMP	FEZF1	266	A0PJY2
GYALYQRHIKAMHES	NCOR1	956	O75376
QLQGSHNYSTAHMLK	PTPN14	546	Q15678
HNYSTAHMLKNYLFR	PTPN14	551	Q15678
NYISNHTLAEMSKGH	SCN9A	1036	Q15858
AHSHLRYKGTLSMLQ	SMG9	396	Q9H0W8
VRIGQLMHYDYSSHK	ST8SIA3	121	O43173
KEYFQHARTHCGNML	PHYHIP	146	Q92561
ALFQHFMHQKLGIAY	SP110	11	Q9HB58
QLALNFTAHMAYRKG	MRPS2	126	Q9Y399
HAASDTQMKLLYHFQ	HES5	106	Q5TA89
KHYEMLANRTAANGH	SEC23B	331	Q15437
QTGLYMHKNRSHIKD	PIGW	321	Q7Z7B1
KMTLSYAEYLAHRQH	AMMECR1	301	Q9Y4X0
GNKMFTHYDRAHIAQ	CLTCL1	601	P53675
AAGMVYLASQHFVHR	NTRK2	661	Q16620
FKYFASLDNHMGIHT	ZNF561	206	Q8N587
TPKNLHRIFMHLTNY	TTLL11	421	Q8NHH1
AFSQKSYLMLHQRGH	ZNF182	466	P17025
GKAFYHLGSFQRHMI	ZNF441	286	Q8N8Z8
QLLYAFFTRTHGDMH	TRIB3	131	Q96RU7
FNMFSSLNNHKRIHT	ZNF723	266	P0DPD5
DKSFHYRSQLQNHML	ZNF710	441	Q8N1W2
MHHYNAGVKQSALLG	TEX10	66	Q9NXF1
MHLTNYSINKHSSNF	TTLL6	261	Q8N841
MFKDSYHNLRLSLHD	UNC5B	746	Q8IZJ1
QYKYQLRSHMSIHIG	ZBTB47	586	Q9UFB7
NHYLSKYQAAMSHLL	PTGR3	306	Q8N4Q0
HNKLKQGQSMHFSNY	TMEM225	121	Q6GV28
SKANHLLLNTFGMYR	SLC30A4	391	O14863
HMKRAHSYAGALQES	ZNF236	1796	Q9UL36
KMSIFNQHTYLSQHS	ZNF420	116	Q8TAQ5
FGHIILNSMHKYQPR	TBX4	181	P57082
YKYQLRSHMSIHIGH	ZNF652	396	Q9Y2D9
RSSMLTGKYVHNHNV	SULF1	91	Q8IWU6
VLSYLTSFQNHLGMH	ZNF433	346	Q8N7K0
KRFYMNSQGHSHQRA	ZNF284	406	Q2VY69
LRAHNTHGREKMYDF	ZNF114	236	Q8NC26
KYRHQGNMLQIGYHL	GLYATL2	231	Q8WU03
VHQINGHKFMATYLR	PRKCH	166	P24723