Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	TNRC18 SALL1 BHLHE22 SREBF2 NAP1L3 MLLT6 CHD1 POU4F2 BRD3 MED1 NUP153 PHC2	2.01e-07	739	50	12	GO:0003682
GeneOntologyMolecularFunction	molecular condensate scaffold activity	UBQLN2 BRD3 NUP153	1.58e-04	42	50	3	GO:0140693
GeneOntologyMolecularFunction	E-box binding	BHLHE22 SREBF2 OLIG2	4.80e-04	61	50	3	GO:0070888
GeneOntologyMolecularFunction	histone binding	NAP1L3 MLLT6 CHD1 BRD3 PHC2	5.16e-04	265	50	5	GO:0042393
GeneOntologyMolecularFunction	modification-dependent protein binding	UBQLN2 UBQLN1 CHD1 BRD3	1.75e-03	206	50	4	GO:0140030
GeneOntologyMolecularFunction	structural constituent of nuclear pore	NUP214 NUP153	1.78e-03	25	50	2	GO:0017056
GeneOntologyMolecularFunction	nuclear localization sequence binding	NUP214 NUP153	2.07e-03	27	50	2	GO:0008139
GeneOntologyMolecularFunction	protein serine kinase activity	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	2.09e-03	363	50	5	GO:0106310
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	UBQLN2 RLIM DYRK1B DYRK1A HIPK2 BRD3 ZC3H18 MED1 NUP153	2.12e-03	1160	50	9	GO:0030674
GeneOntologyCellularComponent	nuclear speck	RNPS1 CCNL1 DYRK1A POU4F2 ZC3H18 ZNF395 PNISR	7.01e-05	431	50	7	GO:0016607
GeneOntologyCellularComponent	nuclear body	RNPS1 CCNL1 DYRK1A HIPK2 POU4F2 ZC3H18 ZNF395 PNISR SH3BP5	2.56e-04	903	50	9	GO:0016604
GeneOntologyCellularComponent	transcription regulator complex	SALL1 RLIM HIPK2 POU4F2 MED1 SNAPC4 OLIG2	5.10e-04	596	50	7	GO:0005667
GeneOntologyCellularComponent	chromatin	SOX11 SALL1 BHLHE22 SREBF2 NAP1L3 CHD1 POU4F2 BRD3 MED1 OLIG2 PHC2	6.17e-04	1480	50	11	GO:0000785
Domain	Ubiquilin-1/2	UBQLN2 UBQLN1	7.02e-06	2	50	2	IPR028430
Domain	Ubiquilin	UBQLN2 UBQLN1	1.05e-04	6	50	2	IPR015496
Domain	UBA	UBQLN2 UBQLN1 USP24	2.21e-04	44	50	3	IPR015940
Domain	UBA	UBQLN2 UBQLN1 USP24	2.69e-04	47	50	3	PS50030
Domain	STI1_HS-bd	UBQLN2 UBQLN1	3.12e-04	10	50	2	IPR006636
Domain	STI1	UBQLN2 UBQLN1	3.12e-04	10	50	2	SM00727
Domain	UBA-like	UBQLN2 UBQLN1 USP24	6.70e-04	64	50	3	IPR009060
Domain	6-PGluconate_DH_C-like	UBQLN2 UBQLN1	1.17e-03	19	50	2	IPR008927
Domain	Ser/Thr_kinase_AS	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	2.60e-03	357	50	5	IPR008271
Domain	S_TKc	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	2.66e-03	359	50	5	SM00220
Domain	PROTEIN_KINASE_ST	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	2.76e-03	362	50	5	PS00108
Domain	UBA	UBQLN2 UBQLN1	2.91e-03	30	50	2	SM00165
Domain	-	BHLHE22 SREBF2 OLIG2	3.10e-03	109	50	3	4.10.280.10
Domain	HLH	BHLHE22 SREBF2 OLIG2	3.27e-03	111	50	3	PF00010
Domain	Protein_kinase_ATP_BS	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	3.36e-03	379	50	5	IPR017441
Domain	HLH	BHLHE22 SREBF2 OLIG2	3.70e-03	116	50	3	SM00353
Domain	BHLH	BHLHE22 SREBF2 OLIG2	3.79e-03	117	50	3	PS50888
Domain	bHLH_dom	BHLHE22 SREBF2 OLIG2	3.88e-03	118	50	3	IPR011598
Domain	UBA	UBQLN2 UBQLN1	4.18e-03	36	50	2	PF00627
Domain	UBIQUITIN_1	UBQLN2 UBQLN1	4.41e-03	37	50	2	PS00299
Domain	UBQ	UBQLN2 UBQLN1	5.91e-03	43	50	2	SM00213
Domain	ubiquitin	UBQLN2 UBQLN1	7.03e-03	47	50	2	PF00240
Domain	PROTEIN_KINASE_ATP	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	7.49e-03	459	50	5	PS00107
Domain	PDZ	WHRN DEPTOR PCLO	7.69e-03	151	50	3	PS50106
Domain	PDZ	WHRN DEPTOR PCLO	7.83e-03	152	50	3	IPR001478
Domain	UBIQUITIN_2	UBQLN2 UBQLN1	9.20e-03	54	50	2	PS50053
Domain	Prot_kinase_dom	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	9.70e-03	489	50	5	IPR000719
Domain	PROTEIN_KINASE_DOM	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	1.00e-02	493	50	5	PS50011
Domain	ZF_C3H1	ZC3H18 ZFC3H1	1.06e-02	58	50	2	PS50103
Domain	Ubiquitin_dom	UBQLN2 UBQLN1	1.06e-02	58	50	2	IPR000626
Domain	Ubiquitin-rel_dom	UBQLN2 UBQLN1 USP24	1.31e-02	184	50	3	IPR029071
Domain	Kinase-like_dom	DYRK1B DYRK1A HIPK2 ULK1 MAP3K21	1.46e-02	542	50	5	IPR011009
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ELOA2 RNPS1 HIPK2 RPRD2 POU4F2 NUP214 MED1 SNAPC4 NUP153 PHC2	2.20e-04	1022	37	10	MM15436
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP214 NUP153 PHC2	2.49e-04	47	37	3	M27395
Pathway	BIOCARTA_NPC_PATHWAY	NUP214 NUP153	3.63e-04	11	37	2	M22033
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP214 NUP153 PHC2	4.65e-04	58	37	3	MM15149
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP214 NUP153 PHC2	6.50e-04	65	37	3	MM15147
Pathway	BIOCARTA_SHH_PATHWAY	DYRK1B DYRK1A	6.89e-04	15	37	2	MM1498
Pathway	PID_SMAD2_3PATHWAY	NUP214 NUP153	7.86e-04	16	37	2	M228
Pathway	BIOCARTA_SHH_PATHWAY	DYRK1B DYRK1A	7.86e-04	16	37	2	M11792
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1	DEPTOR ULK1	7.86e-04	16	37	2	M47457
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP214 NUP153 PHC2	8.41e-04	71	37	3	M27394
Pathway	REACTOME_SUMOYLATION	HIPK2 NUP214 NUP153 PHC2	9.67e-04	169	37	4	MM14919
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP214 NUP153 PHC2	1.07e-03	77	37	3	M27226
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP214 NUP153 PHC2	1.37e-03	84	37	3	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RNPS1 NUP214 NUP153	1.37e-03	84	37	3	M725
Pathway	REACTOME_SUMOYLATION	HIPK2 NUP214 NUP153 PHC2	1.46e-03	189	37	4	M27214
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RNPS1 NUP214 NUP153	1.47e-03	86	37	3	MM15413
Pathway	WP_GDNFRET_SIGNALING_AXIS	SOX11 SALL1	1.50e-03	22	37	2	MM15887
Pathway	WP_GDNFRET_SIGNALING_AXIS	SOX11 SALL1	1.64e-03	23	37	2	M39814
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RNPS1 CCNL1 ASPH USP24 BRD3 ZC3H18 NUP214 MED1 SNAPC4 PNISR PRRC2A NUP153 PHC2	4.94e-11	774	50	13	15302935
Pubmed	The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.	DYRK1B DYRK1A HIPK2	1.12e-08	4	50	3	27307198
Pubmed	The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.	DYRK1B DYRK1A HIPK2	2.79e-08	5	50	3	20940704
Pubmed	TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation.	RNPS1 NUP214 NUP153	1.56e-07	8	50	3	20123736
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 KRT76 UBQLN2 SALL1 UBQLN1 MLLT6 NUP214 NUP153	1.74e-07	430	50	8	35044719
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RNPS1 ASPH RPRD2 BRD3 ZC3H18 NUP214 ZNF395 ZFC3H1 MED1 PNISR NUP153 PHC2	2.19e-07	1294	50	12	30804502
Pubmed	Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.	SOX11 POU4F2 OLIG2	6.09e-07	12	50	3	33674582
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	UBQLN1 CCNL1 ASPH CXXC4 DYRK1A CHD1 BRD3 ZFC3H1 MED1 PNISR PRRC2A PHC2	1.03e-06	1497	50	12	31527615
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	SALL1 BHLHE22 POU4F2 OLIG2	1.05e-06	53	50	4	27210758
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	UBQLN1 BRD3 ZC3H18 MED1 PRRC2A NUP153 PHC2	1.49e-06	394	50	7	27248496
Pubmed	A novel m6A reader Prrc2a controls oligodendroglial specification and myelination.	OLIG2 PRRC2A	2.03e-06	2	50	2	30514900
Pubmed	Mediator coordinates PIC assembly with recruitment of CHD1.	CHD1 MED1	2.03e-06	2	50	2	21979373
Pubmed	Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.	DYRK1B DYRK1A	2.03e-06	2	50	2	34969768
Pubmed	Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.	DYRK1B DYRK1A	2.03e-06	2	50	2	30501876
Pubmed	A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.	UBQLN2 UBQLN1	2.03e-06	2	50	2	29247619
Pubmed	Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.	UBQLN2 UBQLN1	2.03e-06	2	50	2	35063704
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RNPS1 CCNL1 MLLT6 CHD1 BRD3 ZC3H18 MED1 SNAPC4	2.34e-06	608	50	8	36089195
Pubmed	PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors.	SOX11 BHLHE22 OLIG2	2.67e-06	19	50	3	24115909
Pubmed	Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity.	SOX11 BHLHE22 OLIG2	4.85e-06	23	50	3	31082736
Pubmed	A human MAP kinase interactome.	DYRK1B SREBF2 HIPK2 NUP214 MAP3K21 PNISR NUP153	5.92e-06	486	50	7	20936779
Pubmed	Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.	DYRK1B DYRK1A	6.07e-06	3	50	2	32640193
Pubmed	The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.	SOX11 OLIG2	6.07e-06	3	50	2	35301318
Pubmed	DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.	DYRK1B DYRK1A	6.07e-06	3	50	2	21777625
Pubmed	Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev.	NUP214 NUP153	6.07e-06	3	50	2	9847314
Pubmed	Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.	NUP214 NUP153	6.07e-06	3	50	2	12191473
Pubmed	Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.	UBQLN2 UBQLN1	6.07e-06	3	50	2	20529957
Pubmed	DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.	DYRK1B DYRK1A	6.07e-06	3	50	2	30496304
Pubmed	The nuclear pore complex: a new dynamic in HIV-1 replication.	NUP214 NUP153	6.07e-06	3	50	2	21327100
Pubmed	Ubiquitin receptor proteins hHR23a and hPLIC2 interact.	UBQLN2 UBQLN1	6.07e-06	3	50	2	17098253
Pubmed	The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.	SOX11 OLIG2	6.07e-06	3	50	2	20646169
Pubmed	The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.	USP24 ULK1	6.07e-06	3	50	2	30957634
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SALL1 MLLT6 RPRD2 CHD1 ZC3H18 NUP214 MED1 PRRC2A NUP153	7.73e-06	954	50	9	36373674
Pubmed	PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.	UBQLN2 UBQLN1	1.21e-05	4	50	2	19148225
Pubmed	Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.	DYRK1B DYRK1A	1.21e-05	4	50	2	35165364
Pubmed	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.	DYRK1A HIPK2	1.21e-05	4	50	2	34785661
Pubmed	Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.	DYRK1B DYRK1A	1.21e-05	4	50	2	14593110
Pubmed	UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.	UBQLN2 UBQLN1	1.21e-05	4	50	2	36423739
Pubmed	E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.	UBQLN2 UBQLN1	1.21e-05	4	50	2	36827983
Pubmed	Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.	UBQLN2 UBQLN1	1.21e-05	4	50	2	16813565
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN2 UBQLN1	1.21e-05	4	50	2	18307982
Pubmed	Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function.	UBQLN2 RLIM USP24	1.22e-05	31	50	3	36114200
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	RNPS1 DYRK1A RPRD2 ZC3H18 ZFC3H1 NUP153	1.30e-05	361	50	6	30344098
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZC3H18 ZFC3H1 MAP3K21 PNISR PRRC2A NUP153	1.30e-05	361	50	6	26167880
Pubmed	Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.	BHLHE22 POU4F2 OLIG2	1.48e-05	33	50	3	25179941
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	NUP214 OLIG2 NUP153	1.62e-05	34	50	3	18539113
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	DEPTOR ZNF395 PRRC2A	1.77e-05	35	50	3	26091241
Pubmed	Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.	NUP214 NUP153	2.02e-05	5	50	2	12138183
Pubmed	Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.	UBQLN2 UBQLN1	2.02e-05	5	50	2	15975090
Pubmed	A giant nucleopore protein that binds Ran/TC4.	NUP214 NUP153	2.02e-05	5	50	2	7603572
Pubmed	Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells.	SOX11 BHLHE22	2.02e-05	5	50	2	18640244
Pubmed	Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.	NUP214 NUP153	2.02e-05	5	50	2	11777942
Pubmed	Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.	UBQLN2 UBQLN1	2.02e-05	5	50	2	10549293
Pubmed	Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.	NUP214 NUP153	2.02e-05	5	50	2	12917407
Pubmed	The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase.	NUP214 NUP153	2.02e-05	5	50	2	16730000
Pubmed	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.	UBQLN2 UBQLN1	2.02e-05	5	50	2	11827521
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TNRC18 SALL1 PCLO DYRK1B DYRK1A BRD3	2.25e-05	398	50	6	35016035
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 TMCC2 DYRK1A MLLT6 NUP214 ZNF395 ULK1 SNAPC4 PHC2	2.48e-05	1105	50	9	35748872
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ELOA2 UBQLN2 UBQLN1 RNPS1 MLLT6 PRRC2A PHC2	2.51e-05	608	50	7	16713569
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RNPS1 ASPH CHD1 BRD3 ZC3H18 ZFC3H1 PRRC2A NUP153	2.60e-05	847	50	8	35850772
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	SALL1 RNPS1 TRIM71 CHD1 MED1 PHC2	2.69e-05	411	50	6	35182466
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN2 UBQLN1	3.03e-05	6	50	2	35247097
Pubmed	Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.	DYRK1B DYRK1A	3.03e-05	6	50	2	14500717
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	DYRK1A RPRD2 NUP214 ZFC3H1 MED1 NUP153	3.93e-05	440	50	6	34244565
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	TNRC18 RNPS1 CHD1 ZC3H18 NUP214 PRRC2A NUP153	4.03e-05	655	50	7	35819319
Pubmed	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.	UBQLN2 UBQLN1	4.23e-05	7	50	2	10983987
Pubmed	Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.	UBQLN2 UBQLN1	4.23e-05	7	50	2	23774650
Pubmed	Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.	UBQLN2 UBQLN1	4.23e-05	7	50	2	27345149
Pubmed	Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.	HIPK2 POU4F2	4.23e-05	7	50	2	18378044
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	UBQLN2 UBQLN1	4.23e-05	7	50	2	20059542
Pubmed	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.	UBQLN2 UBQLN1	4.23e-05	7	50	2	18199683
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 UBQLN1	4.23e-05	7	50	2	30664872
Pubmed	Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.	UBQLN2 UBQLN1	4.23e-05	7	50	2	18535780
Pubmed	Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.	NUP214 NUP153	4.23e-05	7	50	2	11238447
Pubmed	Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.	DYRK1B DYRK1A	4.23e-05	7	50	2	9748265
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX11 SALL1 BHLHE22 SREBF2 POU4F2 ZNF395 SNAPC4 OLIG2	4.25e-05	908	50	8	19274049
Pubmed	Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.	SOX11 OLIG2	5.64e-05	8	50	2	17515609
Pubmed	Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.	NUP214 NUP153	5.64e-05	8	50	2	31375530
Pubmed	Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.	DYRK1A OLIG2	5.64e-05	8	50	2	34587162
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN2 UBQLN1	5.64e-05	8	50	2	23459205
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	ASPH DYRK1A CHD1 BRD3 PNISR	7.12e-05	300	50	5	28561026
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL1 DYRK1A	7.25e-05	9	50	2	14623875
Pubmed	Cloning and characterization of human karyopherin beta3.	NUP214 NUP153	7.25e-05	9	50	2	9114010
Pubmed	Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.	RLIM OLIG2	7.25e-05	9	50	2	29650591
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBQLN2 UBQLN1 DYRK1A NAP1L3 ZFC3H1 PNISR OLIG2 PRRC2A SH3BP5	7.97e-05	1285	50	9	35914814
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	USP24 RPRD2 MED1 PRRC2A NUP153 SH3BP5	8.23e-05	503	50	6	16964243
Pubmed	Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.	NUP214 NUP153	9.05e-05	10	50	2	19581287
Pubmed	The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.	NUP214 NUP153	9.05e-05	10	50	2	18596238
Pubmed	Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.	ZC3H18 ZFC3H1	9.05e-05	10	50	2	27871484
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SOX11 UBQLN2 UBQLN1 SREBF2 RPRD2	9.93e-05	322	50	5	26514267
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBQLN2 UBQLN1 PRRC2A	1.20e-04	66	50	3	24811749
Pubmed	Dual-utility NLS drives RNF169-dependent DNA damage responses.	DYRK1B DYRK1A	1.32e-04	12	50	2	28325877
Pubmed	Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.	BHLHE22 POU4F2	1.32e-04	12	50	2	20949055
Pubmed	Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome.	DYRK1A OLIG2	1.32e-04	12	50	2	36402907
Pubmed	Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.	POU4F2 OLIG2	1.32e-04	12	50	2	21771810
Pubmed	PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.	UBQLN2 UBQLN1	1.32e-04	12	50	2	31904842
Pubmed	Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.	SOX11 POU4F2	1.32e-04	12	50	2	23649630
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	RPRD2 ZC3H18 ZFC3H1 NUP153	1.41e-04	183	50	4	28186131
Pubmed	UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.	UBQLN2 UBQLN1	1.56e-04	13	50	2	27477512
Pubmed	The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.	DYRK1A POU4F2	1.56e-04	13	50	2	19081073
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	SALL1 DYRK1A RPRD2 NUP214 NUP153	1.61e-04	357	50	5	37059091
Interaction	NFKBIL1 interactions	TNRC18 RNPS1 NAP1L3 BRD3 ZC3H18 SNAPC4	1.11e-07	93	50	6	int:NFKBIL1
Interaction	SMIM19 interactions	UBQLN2 UBQLN1 ASPH	4.99e-07	7	50	3	int:SMIM19
Interaction	WFDC12 interactions	UBQLN2 UBQLN1 ASPH	7.98e-07	8	50	3	int:WFDC12
Interaction	ZG16 interactions	UBQLN2 UBQLN1 ASPH	3.11e-06	12	50	3	int:ZG16
Interaction	PLAAT2 interactions	UBQLN2 UBQLN1 ASPH	4.04e-06	13	50	3	int:PLAAT2
Interaction	SOD3 interactions	UBQLN2 UBQLN1 ASPH	4.04e-06	13	50	3	int:SOD3
Interaction	GUCA2A interactions	UBQLN2 UBQLN1 ASPH	7.87e-06	16	50	3	int:GUCA2A
Interaction	CAMKV interactions	TNRC18 RNPS1 BRD3 ZC3H18 PNISR	1.08e-05	118	50	5	int:CAMKV
Interaction	PRAP1 interactions	UBQLN2 UBQLN1 ASPH	1.14e-05	18	50	3	int:PRAP1
Interaction	SCML1 interactions	RNPS1 BRD3 ZC3H18 PHC2	1.38e-05	59	50	4	int:SCML1
Interaction	SRGN interactions	UBQLN2 UBQLN1 ZFC3H1	1.59e-05	20	50	3	int:SRGN
Interaction	BTRC interactions	UBQLN2 DEPTOR RNPS1 DYRK1A HIPK2 RPRD2 CHD1 ZNF395 PRRC2A NUP153	1.70e-05	775	50	10	int:BTRC
Interaction	SMIM2 interactions	UBQLN2 UBQLN1	1.81e-05	3	50	2	int:SMIM2
Interaction	DEFB115 interactions	UBQLN2 UBQLN1	1.81e-05	3	50	2	int:DEFB115
Interaction	DMKN interactions	UBQLN2 UBQLN1 DMKN	3.18e-05	25	50	3	int:DMKN
Interaction	ETNK1 interactions	UBQLN2 UBQLN1 BRD3	3.18e-05	25	50	3	int:ETNK1
Interaction	RSRC2 interactions	UBQLN2 UBQLN1 BRD3 ZC3H18	3.58e-05	75	50	4	int:RSRC2
Interaction	LOC102723553 interactions	UBQLN2 ASPH	3.61e-05	4	50	2	int:LOC102723553
Interaction	LCN2 interactions	ELOA2 UBQLN2 UBQLN1 ASPH POU4F2	4.85e-05	161	50	5	int:LCN2
Interaction	GAL interactions	UBQLN2 UBQLN1 ASPH	5.02e-05	29	50	3	int:GAL
Interaction	GUCA2B interactions	UBQLN2 UBQLN1	6.00e-05	5	50	2	int:GUCA2B
Interaction	SUMO1 interactions	SALL1 SREBF2 HIPK2 BRD3 PRRC2A NUP153	7.43e-05	287	50	6	int:SUMO1
Interaction	RNPS1 interactions	ELOA2 RNPS1 CCNL1 ASPH BRD3 ZC3H18 PNISR	8.06e-05	425	50	7	int:RNPS1
Interaction	DHX8 interactions	RNPS1 RPRD2 CHD1 ZC3H18 ZFC3H1 PNISR	8.17e-05	292	50	6	int:DHX8
Interaction	C1QTNF4 interactions	UBQLN2 UBQLN1	8.99e-05	6	50	2	int:C1QTNF4
Interaction	AP2A1 interactions	UBQLN2 RNPS1 RLIM DYRK1A BRD3 CFAP97	9.31e-05	299	50	6	int:AP2A1
Interaction	TOPORS interactions	RNPS1 BRD3 ZC3H18 PHC2	9.41e-05	96	50	4	int:TOPORS
Interaction	CSNK2A1 interactions	RNPS1 CCNL1 USP24 RPRD2 BRD3 ZC3H18 ZFC3H1 SNAPC4 CFAP97 PHC2	1.00e-04	956	50	10	int:CSNK2A1
Interaction	SMG7 interactions	SALL1 MLLT6 TRIM71 RPRD2 SNAPC4 PRRC2A	1.33e-04	319	50	6	int:SMG7
Interaction	NAP1L2 interactions	NAP1L3 OLIG2 SH3BP5	1.33e-04	40	50	3	int:NAP1L2
Interaction	CCNL2 interactions	RNPS1 CCNL1 DYRK1A BRD3	1.38e-04	106	50	4	int:CCNL2
Interaction	NUP43 interactions	RNPS1 RLIM MLLT6 CHD1 ZC3H18 NUP214 ZFC3H1 NUP153	1.39e-04	625	50	8	int:NUP43
Interaction	DOT1L interactions	RNPS1 ASPH MLLT6 CHD1 BRD3 ZC3H18 ZFC3H1 PRRC2A NUP153	1.45e-04	807	50	9	int:DOT1L
Interaction	GPR162 interactions	UBQLN2 UBQLN1	1.67e-04	8	50	2	int:GPR162
Interaction	H3C3 interactions	CCNL1 RLIM MLLT6 CHD1 BRD3 ZC3H18 MED1	2.07e-04	495	50	7	int:H3C3
Interaction	EPS15 interactions	UBQLN2 UBQLN1 RNPS1 DYRK1A MLLT6	2.10e-04	220	50	5	int:EPS15
Interaction	DAXX interactions	TNRC18 RNPS1 HIPK2 MLLT6 BRD3 ZC3H18	2.30e-04	353	50	6	int:DAXX
Interaction	CTR9 interactions	SREBF2 RPRD2 CHD1 ZC3H18 SNAPC4	2.74e-04	233	50	5	int:CTR9
Interaction	IGFBP6 interactions	UBQLN2 UBQLN1 POU4F2	2.75e-04	51	50	3	int:IGFBP6
Interaction	PNISR interactions	RNPS1 DYRK1A PNISR	2.75e-04	51	50	3	int:PNISR
Interaction	IGHM interactions	ELOA2 USP24 SREBF2 MAP3K21	3.03e-04	130	50	4	int:IGHM
Interaction	C1orf226 interactions	RNPS1 DYRK1A BRD3	3.08e-04	53	50	3	int:C1orf226
Interaction	SERPINE1 interactions	UBQLN2 UBQLN1 DYRK1B	3.26e-04	54	50	3	int:SERPINE1
Interaction	SEZ6L interactions	UBQLN2 UBQLN1	3.27e-04	11	50	2	int:SEZ6L
Interaction	RTL8A interactions	UBQLN2 UBQLN1	3.27e-04	11	50	2	int:RTL8A
Interaction	PAQR9 interactions	UBQLN2 UBQLN1	3.27e-04	11	50	2	int:PAQR9
Interaction	PLAAT3 interactions	UBQLN2 UBQLN1	3.27e-04	11	50	2	int:PLAAT3
Interaction	CSNK2A2 interactions	RNPS1 CCNL1 BRD3 ZC3H18 ZFC3H1 SNAPC4 CFAP97 PHC2	3.56e-04	718	50	8	int:CSNK2A2
Interaction	FDCSP interactions	UBQLN2 ASPH	3.92e-04	12	50	2	int:FDCSP
Interaction	ZFAND2B interactions	UBQLN2 UBQLN1 PRRC2A	4.45e-04	60	50	3	int:ZFAND2B
Interaction	RTL8B interactions	UBQLN2 UBQLN1	4.62e-04	13	50	2	int:RTL8B
Interaction	C10orf71 interactions	DYRK1B DYRK1A	4.62e-04	13	50	2	int:C10orf71
Interaction	H2BC3 interactions	UBQLN1 DYRK1A BRD3 ZC3H18 MED1 NUP153	4.84e-04	406	50	6	int:H2BC3
Interaction	VWC2 interactions	UBQLN2 UBQLN1 POU4F2	4.90e-04	62	50	3	int:VWC2
Interaction	SLX4 interactions	SALL1 DYRK1A RPRD2 CHD1 NUP214 ZFC3H1 NUP153	4.96e-04	572	50	7	int:SLX4
Interaction	MED23 interactions	DYRK1B DYRK1A BRD3 MED1 PNISR	5.03e-04	266	50	5	int:MED23
Interaction	FAM117A interactions	DYRK1B DYRK1A	5.39e-04	14	50	2	int:FAM117A
Interaction	UBQLN4 interactions	UBQLN2 UBQLN1 RNPS1 MLLT6 PRRC2A	5.57e-04	272	50	5	int:UBQLN4
Interaction	ANAPC16 interactions	DYRK1A BRD3 CFAP97	5.63e-04	65	50	3	int:ANAPC16
Interaction	NXF2 interactions	DYRK1A NUP214 NUP153	5.63e-04	65	50	3	int:NXF2
Interaction	HMGA1 interactions	TNRC18 PCLO USP24 HIPK2 CHD1 ZC3H18	5.71e-04	419	50	6	int:HMGA1
Interaction	SREK1IP1 interactions	ELOA2 CCNL1 NUP153	5.89e-04	66	50	3	int:SREK1IP1
Interaction	PPP1R3F interactions	DYRK1B DYRK1A	6.20e-04	15	50	2	int:PPP1R3F
Interaction	FAM53C interactions	DYRK1B DYRK1A MAP3K21	6.43e-04	68	50	3	int:FAM53C
Interaction	JPH4 interactions	UBQLN2 UBQLN1 ZC3H18	6.43e-04	68	50	3	int:JPH4
Interaction	MAP3K1 interactions	UBQLN1 DYRK1B DYRK1A HIPK2	6.79e-04	161	50	4	int:MAP3K1
Interaction	RSBN1 interactions	RNPS1 TRIM71 BRD3 ZC3H18	6.79e-04	161	50	4	int:RSBN1
Interaction	SMC5 interactions	SALL1 MLLT6 RPRD2 CHD1 ZC3H18 NUP214 MED1 PRRC2A NUP153	7.02e-04	1000	50	9	int:SMC5
Interaction	H2BW1 interactions	NAP1L3 ZC3H18	7.08e-04	16	50	2	int:H2BW1
Interaction	UBFD1 interactions	UBQLN2 UBQLN1 PRRC2A	7.60e-04	72	50	3	int:UBFD1
Interaction	PRPF40A interactions	UBQLN2 UBQLN1 RNPS1 CCNL1 BRD3 ZC3H18	7.92e-04	446	50	6	int:PRPF40A
Interaction	ZNF330 interactions	SALL1 MLLT6 CHD1 BRD3 ZC3H18 ZFC3H1	7.92e-04	446	50	6	int:ZNF330
Interaction	RHBDF2 interactions	ASPH NUP214 PRRC2A NUP153	7.96e-04	168	50	4	int:RHBDF2
Interaction	SMAD3 interactions	SREBF2 DYRK1A HIPK2 NUP214 NUP153 PHC2	8.01e-04	447	50	6	int:SMAD3
Interaction	NOVA2 interactions	BRD3 ZC3H18	8.01e-04	17	50	2	int:NOVA2
Interaction	SDHAP2 interactions	ZFC3H1 PRRC2A	8.01e-04	17	50	2	int:SDHAP2
Interaction	COL9A2 interactions	UBQLN2 UBQLN1	8.01e-04	17	50	2	int:COL9A2
Interaction	MFAP1 interactions	CCNL1 DYRK1A BRD3 ZC3H18 PHC2	8.03e-04	295	50	5	int:MFAP1
Interaction	KIAA0232 interactions	DYRK1B DYRK1A SNAPC4	8.23e-04	74	50	3	int:KIAA0232
Interaction	CSNK2B interactions	RNPS1 CCNL1 BRD3 ZC3H18 SNAPC4 CFAP97 PHC2	8.37e-04	625	50	7	int:CSNK2B
Interaction	PHF5A interactions	UBQLN2 ZC3H18 ULK1 NUP153	8.50e-04	171	50	4	int:PHF5A
Interaction	THAP3 interactions	SREBF2 TRIM71 PHC2	8.56e-04	75	50	3	int:THAP3
Interaction	RNF208 interactions	KRT76 UBQLN2 UBQLN1	8.56e-04	75	50	3	int:RNF208
Interaction	POLR2L interactions	RPRD2 ZC3H18 MED1 PHC2	8.69e-04	172	50	4	int:POLR2L
Interaction	NPY interactions	UBQLN2 UBQLN1	9.00e-04	18	50	2	int:NPY
Interaction	SERPINI2 interactions	UBQLN2 UBQLN1	9.00e-04	18	50	2	int:SERPINI2
Interaction	NBL1 interactions	UBQLN2 UBQLN1	9.00e-04	18	50	2	int:NBL1
Interaction	CDIP1 interactions	UBQLN2 UBQLN1	9.00e-04	18	50	2	int:CDIP1
Cytoband	Ensembl 112 genes in cytogenetic band chr8q12	BHLHE22 ASPH	4.57e-03	92	50	2	chr8q12
GeneFamily	Ubiquilin family	UBQLN2 UBQLN1	2.84e-05	5	31	2	783
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PCLO ZFC3H1	2.95e-04	15	31	2	26
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC18 BHLHE22	8.33e-04	25	31	2	775
GeneFamily	Basic helix-loop-helix proteins	BHLHE22 SREBF2 OLIG2	8.70e-04	110	31	3	420
GeneFamily	Nucleoporins	NUP214 NUP153	1.37e-03	32	31	2	1051
GeneFamily	PDZ domain containing	WHRN DEPTOR PCLO	2.20e-03	152	31	3	1220
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	USP24 DYRK1A CHD1 ZFC3H1 PNISR NUP153 PHC2	1.57e-06	300	50	7	M8702
Coexpression	GSE20715_0H_VS_6H_OZONE_TLR4_KO_LUNG_DN	DMKN ASPH USP24 DYRK1A CHD1 NUP153	2.20e-06	200	50	6	M4373
Coexpression	GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN	RNPS1 CCNL1 NUP214 SNAPC4 PRRC2A	2.65e-05	184	50	5	M19988
Coexpression	GSE4748_CTRL_VS_CYANOBACTERIUM_LPSLIKE_STIM_DC_1H_UP	UBQLN2 UBQLN1 BHLHE22 OLIG2 PHC2	3.94e-05	200	50	5	M6486
Coexpression	DAZARD_RESPONSE_TO_UV_SCC_DN	DYRK1A CHD1 NUP153 PHC2	6.93e-05	115	50	4	M7484
Coexpression	THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	NUP214 ULK1 NUP153 PHC2 ITPKB	7.19e-05	227	50	5	M11234
Coexpression	RUTELLA_RESPONSE_TO_HGF_DN	DEPTOR CCNL1 NUP214 ZNF395 SH3BP5	9.35e-05	240	50	5	M6413
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 NAP1L3 SH3BP5	2.90e-06	199	50	5	0cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DEPTOR TMCC2 ZNF395 ULK1	9.12e-06	117	50	4	f0c738b6b850733f9af68704172554177a1c1198
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DEPTOR TMCC2 ZNF395 ULK1	9.12e-06	117	50	4	b5cb9d69ddd42331134f7e4bd51bd1c31030893c
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HIPK2 PHC2 SH3BP5 ITPKB	4.94e-05	180	50	4	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HIPK2 PHC2 SH3BP5 ITPKB	5.50e-05	185	50	4	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	3'_v3-blood\|World / Manually curated celltypes from each tissue	CCNL1 ULK1 PNISR PHC2	5.73e-05	187	50	4	9e70e8d7cd8ae517ddf5fd56c69ec16fc33ddff5
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	CCNL1 USP24 DYRK1A CHD1	5.85e-05	188	50	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WHRN HIPK2 OLIG2 ITPKB	6.10e-05	190	50	4	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WHRN HIPK2 OLIG2 ITPKB	6.22e-05	191	50	4	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CCNL1 SREBF2 ZFC3H1 NUP153	6.35e-05	192	50	4	6bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCell	background-Cholangiocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	DMKN PCLO MAP3K21 GOLGA7B	6.48e-05	193	50	4	9152241073dbe02ac2c11d86bec9b5b529196f6e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CCNL1 SREBF2 CHD1 NUP153	6.48e-05	193	50	4	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-INs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 BRD3 TPGS2 SH3BP5	6.88e-05	196	50	4	556e18eae05bf19259fe02848bcc9120aa2a9d29
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 GOLGA7B	7.01e-05	197	50	4	10e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNL1 USP24 ZFC3H1 PNISR	7.01e-05	197	50	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	PCLO CXXC4 NAP1L3 SH3BP5	7.01e-05	197	50	4	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CCNL1 ZFC3H1 PNISR PRRC2A	7.01e-05	197	50	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.15e-05	198	50	4	076c862f2a723f0361749377561cae902068b1a0
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO BHLHE22 NAP1L3 SH3BP5	7.15e-05	198	50	4	a0032e3ed259e39324a659490b9d340c5d9ba0fc
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Immature_CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 DEPTOR BHLHE22 SH3BP5	7.15e-05	198	50	4	4e598aab92141e7d32ec963291ddeed14a21beba
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNL1 USP24 ZFC3H1 PNISR	7.29e-05	199	50	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Neuron\|World / Primary Cells by Cluster	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	1f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell	Neuron-Postmitotic\|World / Primary Cells by Cluster	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	1973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	1029f3458b7fda464aa0e7ef06e081e2618c1388
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal-PNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	8a04398653a1794921d73a6a950c1fb6fdf68c85
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	SOX11 PCLO BHLHE22 SH3BP5	7.29e-05	199	50	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 GOLGA7B	7.44e-05	200	50	4	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO CXXC4 GOLGA7B	7.44e-05	200	50	4	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon\|organoid_Velasco_nature / Sample Type, Dataset, Time_group, and Cell type.	PCLO BHLHE22 NAP1L3 SH3BP5	7.44e-05	200	50	4	f6d6a2f4e2f51c292dfb97280353a49117798fc6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal\|2m / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO NAP1L3 SH3BP5	7.44e-05	200	50	4	60b86c4a4e247b2673d31b085b440a6e574393bb
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.44e-05	200	50	4	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNL1 CHD1 ZFC3H1 PNISR	7.44e-05	200	50	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal\|3m / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PCLO BHLHE22 SH3BP5	7.44e-05	200	50	4	af99d90070e2933fd2e9512590c6cf3bd6e15539
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	DYRK1A HIPK2 RPRD2 MED1 PNISR ITPKB	2.43e-06	177	50	6	7047_DN
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN2 UBQLN1	8.10e-06	3	49	2	DOID:0060206 (implicated_via_orthology)
Disease	manic episode measurement, depressive episode measurement	WHRN DEPTOR	9.65e-05	9	49	2	EFO_0007704, EFO_0007705
Disease	depressive episode measurement	WHRN DEPTOR	1.47e-04	11	49	2	EFO_0007704
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN2 UBQLN1	1.76e-04	12	49	2	DOID:9255 (implicated_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	DYRK1B DYRK1A	2.80e-04	15	49	2	DOID:14250 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	DYRK1B DYRK1A	3.19e-04	16	49	2	DOID:0050888 (implicated_via_orthology)
Disease	C-reactive protein measurement	SALL1 DEPTOR TMCC2 CCNL1 DYRK1A BRD3 AGBL5 SNAPC4	7.72e-04	1206	49	8	EFO_0004458
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN2 UBQLN1	1.14e-03	30	49	2	DOID:332 (implicated_via_orthology)
Disease	eosinophil percentage of leukocytes	SALL1 DYRK1A CHD1 BRD3 OLIG2 ITPKB	1.42e-03	746	49	6	EFO_0007991
Disease	aspartate aminotransferase measurement	WHRN TMCC2 BRD3 ZC3H18 NUP214 PRRC2A	3.70e-03	904	49	6	EFO_0004736
Disease	Microcephaly	DYRK1A NUP214	5.58e-03	67	49	2	C0025958
Disease	dentures	SALL1 ITPKB	6.07e-03	70	49	2	EFO_0010078
Disease	dental caries, dentures	SALL1 ITPKB	6.07e-03	70	49	2	EFO_0003819, EFO_0010078
Disease	intellectual disability (implicated_via_orthology)	DYRK1B DYRK1A	6.94e-03	75	49	2	DOID:1059 (implicated_via_orthology)
Disease	basophil percentage of leukocytes	TMCC2 DYRK1A CHD1	7.69e-03	243	49	3	EFO_0007992

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFSTGTSAGGSSSSQ	AGBL5	641	Q8NDL9
SASSSSSSSSSSSGG	MLLT6	326	P55198
SSSESGSSSSSGSSS	BRD3	706	Q15059
GSSSSSGSSSDSSDS	BRD3	711	Q15059
SSSSSSLSSSSSGSG	CFAP97	171	Q9P2B7
SSSGSGGSSKSQSST	SH3BP5	406	O60239
SGSGGSSSSSSSSSK	BHLHE22	221	Q8NFJ8
GNSSSSGSGSGSTSA	ASPH	11	Q12797
SGSGSGSTSAGSSSP	ASPH	16	Q12797
GTTSSTSSSSGGSSG	DYRK1A	506	Q13627
TSSSSGGSSGTSNSG	DYRK1A	511	Q13627
SAGGSSSGTTTTTTT	CCNL1	21	Q9UK58
SASGSGSGSSSGSSS	CHD1	26	O14646
GSGSSSGSSSDGSSS	CHD1	31	O14646
SGSSSDGSSSQSGSS	CHD1	36	O14646
SSTASSISSSGGSSG	DYRK1B	461	Q9Y463
SISSSGGSSGSSSDN	DYRK1B	466	Q9Y463
SSSSSSSGYGVSGGS	KRT76	541	Q01546
SSQSSSGGGRDSSSS	ELOA2	686	Q8IYF1
VTSTSGHSSGSSSGA	HIPK2	1006	Q9H2X6
ASSSSSQTSTSSGGG	TRIM71	31	Q2Q1W2
CSSGSSSSGSSSGSG	GOLGA7B	141	Q2TAP0
SSSGSSSGSGSSSGG	GOLGA7B	146	Q2TAP0
TESSGSDSGGSSSSS	FAM104A	106	Q969W3
SSVSTGSSGSSFGSG	PCLO	4941	Q9Y6V0
SSSSSGSVFGSGNTG	NUP214	1866	P35658
GSESSWGSSTGSSSG	DMKN	301	Q6E0U4
STGSAGSDSSTSGSG	DEPTOR	6	Q8TB45
SSSSSSSSGGAGGAN	CXXC4	116	Q9H2H0
GGGSSKASSSSASSA	RPRD2	6	Q5VT52
GSGTSSGSHSSTAPS	SALL1	136	Q9NSC2
SSSSSSSSSGGGGSS	SALL1	151	Q9NSC2
SSSSGGGGSSSTGTS	SALL1	156	Q9NSC2
SSGSGGSHMSGTSSS	MED1	1226	Q15648
TSSSSSSGSSSGSSG	SOX11	341	P35716
GSSTSTGSSSGSSSS	RNPS1	86	Q15287
SLHSSSGGGSSGSSS	TMCC2	166	O75069
PGGSASSSSTSSGGS	MAP3K21	21	Q5TCX8
SSSSTSSGGSASAGA	MAP3K21	26	Q5TCX8
RLNSSSGSGSGSSGS	ITPKB	81	P27987
SGSGSGSSGSSVSSP	ITPKB	86	P27987
SSSSSSGSSGGGGSE	POU4F2	71	Q12837
SGGGSTSSTSSGSFE	PRRC2A	571	P48634
SSSSSTSGSSSGSGS	NAP1L3	46	Q99457
TSGSSSGSGSSSSSS	NAP1L3	51	Q99457
SGSGSSSSSSGSTSS	NAP1L3	56	Q99457
GGSGFKSSSSSTSSS	OLIG2	71	Q13516
GSSTGSHGTSTTVSS	WHRN	526	Q9P202
GSSSSSSSSSSSGSE	TNRC18	2566	O15417
SGASSSSGCNNSSSG	PHC2	21	Q8IXK0
GGSSSGSSSSSSSSS	RLIM	451	Q9NVW2
SSSSSSPSSSSGGES	RLIM	471	Q9NVW2
SSSASSGTASTVGGT	UBQLN1	331	Q9UMX0
GSSSGSSGSSSSSSN	SREBF2	61	Q12772
SSGSSSSSSNGRGSS	SREBF2	66	Q12772
DSGSSTTSGHWSGSS	ZNF395	211	Q9H8N7
SSSSSSTPATSAGGG	NUP153	1196	P49790
GPSTSSTSKSSSGSG	TPGS2	281	Q68CL5
GSGTPSGSSADSSTS	USP24	1036	Q9UPU5
GRSRSGSSSSGSSSS	PNISR	506	Q8TF01
TSSSGSSSGSSGGSS	SNAPC4	521	Q5SXM2
SSSGSSGGSSSSSSS	SNAPC4	526	Q5SXM2
TTSTTTSTGSGSGNS	UBQLN2	331	Q9UHD9
SGGGGGSSSSSSSSQ	ZFC3H1	66	O60293
PSSGSGSSSSSSSTS	ULK1	296	O75385
GSSGGSSGSHTSSAS	TMEM39B	21	Q9GZU3
GSGSGSGSSYSGSSS	ZC3H18	686	Q86VM9