Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1G

1.96e-0414302GO:0008331
GeneOntologyBiologicalProcessnegative regulation of nucleobase-containing compound transport

RSC1A1 NUP153

6.99e-063322GO:0032240
HumanPhenoNuchal rigidity

CACNA1A TRAF3 TLR3

2.82e-0612133HP:0031179
HumanPhenoCSF lymphocytic pleiocytosis

CACNA1A TRAF3 TLR3

1.23e-0519133HP:0200149
HumanPhenoCSF pleocytosis

CACNA1A TRAF3 TLR3

3.67e-0527133HP:0012229
HumanPhenoCerebral edema

CACNA1A TRAF3 TLR3

6.17e-0532133HP:0002181
HumanPhenoLimitation of neck motion

CACNA1A TRAF3 TLR3

8.83e-0536133HP:0005986
HumanPhenoAbnormal neck physiology

CACNA1A TRAF3 TLR3

8.83e-0536133HP:0025669
HumanPhenoAbnormal CSF glucose concentration

TRAF3 TLR3

8.97e-056132HP:0031884
HumanPhenoHypoglycorrhachia

TRAF3 TLR3

8.97e-056132HP:0011972
HumanPhenoFocal impaired awareness seizure

NSD1 CACNA1A TRAF3 TLR3

2.15e-04126134HP:0002384
HumanPhenoHerpes simplex encephalitis

TRAF3 TLR3

2.67e-0410132HP:0012302
HumanPhenoIncreased CSF protein concentration

CACNA1A TRAF3 TLR3

3.89e-0459133HP:0002922
HumanPhenoAbnormal CSF protein concentration

CACNA1A TRAF3 TLR3

4.50e-0462133HP:0025456
HumanPhenoViral encephalitis

TRAF3 TLR3

4.62e-0413132HP:0033993
DomainVDCCAlpha1

CACNA1A CACNA1G

1.19e-0410312IPR002077
DomainZnf_FYVE_PHD

NSD1 KDM5B ZFYVE27

1.83e-03147313IPR011011
DomainSET

NSD1 PRDM1

2.10e-0341312PF00856
DomainSET

NSD1 PRDM1

2.64e-0346312SM00317
DomainSET_dom

NSD1 PRDM1

3.11e-0350312IPR001214
DomainSET

NSD1 PRDM1

3.11e-0350312PS50280
DomainChannel_four-helix_dom

CACNA1A CACNA1G

4.02e-0357312IPR027359
Domain-

CACNA1A CACNA1G

4.02e-03573121.20.120.350
DomainEGF_extracell

NELL2 ADAM23

4.44e-0360312IPR013111
DomainEGF_2

NELL2 ADAM23

4.44e-0360312PF07974
DomainZinc_finger_PHD-type_CS

NSD1 KDM5B

5.20e-0365312IPR019786
Domain-

NSD1 KDM5B TRAF3 ZFYVE27

6.20e-034493143.30.40.10
DomainZnf_RING/FYVE/PHD

NSD1 KDM5B TRAF3 ZFYVE27

6.70e-03459314IPR013083
DomainPHD

NSD1 KDM5B

6.86e-0375312PF00628
DomainZnf_PHD-finger

NSD1 KDM5B

7.59e-0379312IPR019787
DomainPHD

NSD1 KDM5B

9.54e-0389312SM00249
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

TRAF3 TLR3

8.31e-059222M47451
PathwayREACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION

TRAF3 TLR3

1.27e-0411222M48241
PathwayREACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7

TRAF3 TLR3

1.79e-0413222M27884
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY

TRAF3 TLR3

3.91e-0419222M47450
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1G

5.77e-0423222M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1G

6.82e-0425222M47948
PathwayWP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88

TRAF3 TLR3

1.05e-0331222M39573
PathwayWP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY

TRAF3 TLR3

1.05e-0331222M39897
PathwayWP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION

TRAF3 TLR3

1.05e-0331222M39859
PathwayREACTOME_DISEASES_OF_IMMUNE_SYSTEM

TRAF3 TLR3

1.12e-0332222M27428
PathwayWP_TOLLLIKE_RECEPTOR_SIGNALING

TRAF3 TLR3

1.19e-0333222MM15940
PathwayWP_MITOCHONDRIAL_IMMUNE_RESPONSE_TO_SARSCOV2

TRAF3 TLR3

1.19e-0333222M40066
Pubmed

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

TRAF3 TLR3

8.20e-07232220832341
Pubmed

Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.

CACNA1A CACNA1G

8.20e-07232220547676
Pubmed

The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population.

TRAF3 TLR3

2.46e-06332228479387
Pubmed

Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.

CACNA1A CACNA1G

4.92e-06432231800012
Pubmed

Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.

CACNA1A CACNA1G

4.92e-06432221788606
Pubmed

Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.

CACNA1A CACNA1G

4.92e-06432215175395
Pubmed

Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1.

ETS2 PRDM1

4.92e-06432217977828
Pubmed

The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals.

ZDBF2 ADAM23

1.72e-05732224589776
Pubmed

Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.

ETS2 TRAF3

1.72e-05732212860972
Pubmed

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.

TRAF3 TLR3

1.72e-05732227716849
Pubmed

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.

TRAF3 TLR3

2.29e-05832231511519
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1G

2.94e-05932216382099
Pubmed

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

TRAF3 TLR3

2.94e-05932214982987
Pubmed

The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.

TRAF3 TLR3

4.49e-051132223962979
Pubmed

Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.

CACNA1G TLR3

1.24e-041832231910261
Pubmed

Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.

ETS2 TF

1.24e-04183221783381
Pubmed

Sox2 modulates the function of two distinct cell lineages in mouse skin.

CACNA1A PRDM1

1.70e-042132223948231
Pubmed

TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development.

ETS2 PRDM1

2.05e-042332238828908
Pubmed

The DNA sequence and comparative analysis of human chromosome 10.

PPA1 ZFYVE27 CCNY CC2D2B

2.75e-0434532415164054
Pubmed

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

TF TLR3

3.28e-042932221266579
Pubmed

Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.

PPA1 TF

3.51e-04303221914521
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A KDM5B

4.25e-043332219336002
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

NSD1 KDM5B

4.25e-043332226864203
Pubmed

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

ZDBF2 ADAM23

4.79e-043532222688191
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A CACNA1G

5.65e-043832230786075
Pubmed

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

CACNA1A NUP153

5.95e-043932224095980
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

KDM5B ADAM23 WNT2 PRDM1

5.98e-0442432421731673
Pubmed

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.

CACNA1A CACNA1G

8.28e-044632234815492
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1G

4.51e-0426222253
GeneFamilyPHD finger proteins

NSD1 KDM5B

5.31e-039022288
CoexpressionGSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_6H_UP

FLCN ZNF132 NELL2 PPA1

9.44e-05197324M6512
CoexpressionGSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN

WSB2 KDM5B TRAF3 PRDM1

9.81e-05199324M316
CoexpressionGSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_UP

CACNA1A PPA1 HCK TLR3

1.00e-04200324M8564
CoexpressionGSE32986_CURDLAN_LOWDOSE_VS_CURDLAN_HIGHDOSE_STIM_DC_DN

TRAF3 ADAM23 HCK PRDM1

1.00e-04200324M8635
CoexpressionGSE32986_CURDLAN_HIGHDOSE_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN

ETS2 TRAF3 HCK PRDM1

1.00e-04200324M8631
CoexpressionGSE26343_UNSTIM_VS_LPS_STIM_NFAT5_KO_MACROPHAGE_DN

ETS2 TRAF3 HCK PRDM1

1.00e-04200324M8643
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_8H_BMDC_DN

TRAF3 ADAM23 TF PRDM1

1.00e-04200324M3893
CoexpressionGRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION

CACNA1A NUP153

1.30e-0414322M14308
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#4

CACNA1A NCKAP5 NELL2 ZDBF2 ADAM23

6.63e-05298315Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K4
CoexpressionAtlasMyeloid Cells, MF.169+11chi.SLN, CD11b+ CD169+ CD11chigh, Lymph Node, avg-2

ADAM23 HCK TLR3

1.21e-0466313GSM854315_100
CoexpressionAtlasMyeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7

ETS2 ADAM23 TF HCK PRDM1

2.10e-04381315GSM854262_500
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3

TF HCK TLR3

2.31e-0482313GSM538231_100
CoexpressionAtlasMyeloid Cells, DC.8+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-2

ADAM23 HCK TLR3

2.57e-0485313GSM538258_100
CoexpressionAtlasMyeloid Cells, DC.8+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3

ADAM23 HCK TLR3

2.75e-0487313GSM538252_100
CoexpressionAtlasMyeloid Cells, DC.8-.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

ADAM23 HCK TLR3

2.75e-0487313GSM605831_100
CoexpressionAtlasMyeloid Cells, DC.8+.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

ADAM23 HCK TLR3

2.75e-0487313GSM605828_100
CoexpressionAtlasMyeloid Cells, DC.8+.SLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3

ADAM23 HCK TLR3

2.75e-0487313GSM538255_100
CoexpressionAtlasMyeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3

ADAM23 TF HCK ALPK2 PRDM1

2.91e-04409315GSM605823_500
CoexpressionAtlasMyeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3

ETS2 ADAM23 TF HCK PRDM1

2.97e-04411315GSM538239_500
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000_k-means-cluster#1

CACNA1A NCKAP5 NELL2 ADAM23

3.52e-04233314Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#5

CACNA1A WSB2 NCKAP5 NELL2 ZDBF2 ADAM23

4.17e-04688316Facebase_RNAseq_e10.5_Mandibular Arch_2500_K5
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRTAP16-1 ADAM23 WNT2 PRDM1

8.16e-0618032412537d8a569faa69f474284d2c201475722b8ca1
ToppCellControl_saline-Endothelial-Endothelial-Activated_Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

ETS2 CACNA1A NCKAP5 PRDM1

1.19e-051983243c3a5d2555f6af4aa33f9ea778808315d0e39d86
ToppCellControl-Epithelial_alveolar-AT_2-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NELL2 ALPK2 CFAP65

8.05e-05117323c6fc72608d56a389bcd87b5dc98a11e39b79bcb2
ToppCellURO-Lymphocyte-T_NK-CD8_Naive|URO / Disease, Lineage and Cell Type

NELL2 PPA1 ADAM23

1.20e-04134323142b7db0c2b686c8f2704ff7bcd9b44dfcb07403
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ETS2 TF HCK

1.49e-04144323a9305d2499189f23b942775285be9fb260ce4214
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NCKAP5 ADAM23 HCK

1.52e-04145323a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|390C / Donor, Lineage, Cell class and subclass (all cells)

CACNA1G HCK ALPK2

1.74e-04152323f717aae4882e9b67e5e40f4ef5b0d35f74a89165
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NELL2 ADAM23 PRDM1

1.81e-0415432389c9c9918af32f3952790b41f1471b2c80ffce2f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ETS2 WNT2 PRDM1

1.99e-04159323d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 TESMIN ADAM23

2.34e-04168323af82e07d1eec51fc6530155f37addbce6221885d
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NCKAP5 PPA1 FAM135A

2.38e-04169323e3410ccb3f85811c75694e286115803911169a2f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZDBF2 ADAM23 TLR3

2.38e-04169323b2d53159e344fad6fcdc485d5b8f6cf1bf094b1f
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NCKAP5 PPA1 FAM135A

2.38e-04169323a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ETS2 ALPK2 CC2D2B

2.43e-04170323cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZFYVE27 TESMIN

2.47e-041713233b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZFYVE27 TESMIN

2.47e-04171323fd01076574dcc82bfd4a1538812500543b16794f
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

CACNA1A ZDBF2 HCK

2.51e-041723230657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPA1 ADAM23 CFAP65

2.51e-04172323eba1568d4307e91c94fc616549057cbed8df5840
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

PPA1 HCK ALPK2

2.55e-0417332394f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic|Lung / Manually curated celltypes from each tissue

NCKAP5 PPA1 TESMIN

2.55e-0417332362e0c18cfed9645e34a9d7029c94a8554f773714
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-DC1|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NCKAP5 PPA1 TLR3

2.64e-04175323398e2504021f587166ad04a2f0662bfcb4e1c0df
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|normal_Lung / Location, Cell class and cell subclass

CACNA1G HCK ALPK2

2.91e-04181323b55dbcfae8c92d322071906831489830a22239b9
ToppCelldroplet-Tongue-nan-24m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 HCK ALPK2

2.96e-041823230f06309318c064f0ebdb12a46226b90032290137
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

NCKAP5 TLR3 PRDM1

2.96e-04182323ee137574b8f0e684a4a7cb26226877c471cae433
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

ETS2 PPA1 HCK

3.01e-04183323f482e4fe011fa450a475034b1e25587233855bdb
ToppCell3'_v3-Lung-Myeloid_Dendritic-DC1|Lung / Manually curated celltypes from each tissue

NCKAP5 PPA1 TLR3

3.01e-04183323e4cbd39575b5a4612d9934532e3bad63286f8aa5
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.06e-0418432342d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCelltumor_Lung-Myeloid_cells-CD141+_DCs|tumor_Lung / Location, Cell class and cell subclass

NCKAP5 PPA1 HCK

3.06e-04184323f5cad8eb358898ae536cd7a7b37d3ce19528b801
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3 PPA1 NUP153

3.11e-04185323a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ETS2 CCNY PRDM1

3.11e-04185323673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.16e-04186323962c2dada19185628ead77c32fcb07fa95114247
ToppCellControl-Lymphocyte-T_NK-CD4_TCM|Control / Disease, Lineage and Cell Type

NELL2 ADAM23 PRDM1

3.21e-041873231de80f40f753b31aed1fac9f3ff8a2ee6c755eec
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

NCKAP5 ADAM23 ALPK2

3.21e-0418732378cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

PPA1 HCK PRDM1

3.26e-041883235d12afb483d028ca02b3b4215131f6128e8bcd48
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-DC2|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ETS2 NCKAP5 TLR3

3.26e-0418832315d8dc514d5da46f6af284e7c1c92c606712dae6
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A CACNA1G ALPK2

3.26e-041883231efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.26e-0418832347bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.26e-041883232331a2bae1383820d598e93aa86c75b101069bac
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

ETS2 ADAM23 CC2D2B

3.26e-04188323d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

NCKAP5 ADAM23 ALPK2

3.31e-041893239c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell(3)_MNP-(3)_DC_1|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

NCKAP5 PPA1 TLR3

3.41e-04191323cf0ea54670ed478c3302ccfbee9f6b6706e49fcd
ToppCellCOPD-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.41e-041913233480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NELL2 ADAM23 PRDM1

3.41e-04191323b53b490a8796e819edd3eb4a5a42b4499077b2d3
ToppCellCOPD-Myeloid-cDC1|COPD / Disease state, Lineage and Cell class

NCKAP5 PPA1 TLR3

3.46e-04192323bd3d00b094d92463b06023361a71240851a542b8
ToppCelldistal-1-Hematologic-CD4+_Memory/Effector_T|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NELL2 TESMIN PRDM1

3.46e-04192323e2611de161d629d901765ca0e4db75bb65096a25
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TRAF3 WNT2 NUP153

3.46e-041923236bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TRAF3 NUP153 ALPK2

3.46e-041923233f925a80b5e2b0577d573e88598a2984a5f6a789
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM23 HCK TLR3

3.46e-041923238b4bbbadeac70f65378697120c754f10501b5651
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-conventional_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 CACNA1G PPA1

3.52e-04193323984ea5b871479527ab57dd813bacae844c0d8c06
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 CACNA1G PPA1

3.52e-04193323529281b912070c8655e38880ac73f5e4bd6ee4ce
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

ETS2 CCNY PRDM1

3.52e-04193323479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCellfacs-Bladder-nan-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 WNT2 PRDM1

3.57e-04194323f4c9fc53ae31d58096906d9305b0b4082512a7e9
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETS2 ADAM23 WNT2

3.57e-04194323c8b9551b93a5aed62154b487db90130604a6125c
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ETS2 NCKAP5 PPA1

3.57e-041943235c60670ec24470225fabaa6071fdb4ef6e579840
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NELL2 HCK PRDM1

3.57e-041943234dfc890bacf133cfb6ec7c8b73f084f2491cf78e
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ETS2 NCKAP5 PPA1

3.57e-041943236af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCellBronchial_Brush-Immune-Dendritic_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

ETS2 PPA1 PRDM1

3.57e-04194323dbcc00940538efc0f89f074dbe822c50efa5ad8e
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ETS2 NCKAP5 TLR3

3.57e-04194323e56c6e5c9b7d287ae94566b561e21cec2055f83d
ToppCellILEUM-inflamed-(3)_mature_DC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NELL2 PPA1 HCK

3.57e-04194323369bbf4e8e2d674e5a51a614b52b97d05d3ab9c7
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 WNT2 PRDM1

3.57e-04194323ee6b5fb4e993a4c0dc556091b8fefd56bdc70d8f
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KDM5B TRAF3 PRDM1

3.62e-041953237b181e5b05becec3fd5031849affa9a135b26d3f
ToppCellControl-Myeloid-cDC1|Control / Disease, Lineage and Cell Type

NCKAP5 PPA1 TLR3

3.62e-0419532335b2fe0588877d30cbd5d3ae259fcfd959907429
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 WNT2 PRDM1

3.62e-04195323841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ETS2 NCKAP5 TLR3

3.62e-0419532385fee07d71c0393ea42bcf1130566dff4a62f507
ToppCell(7)_DC_2|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ETS2 PPA1 HCK

3.62e-0419532363abdf512368a32e586f8dc87090796f19a146c6
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-conventional_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 NCKAP5 PPA1

3.62e-041953230fcc41cda3e5f921748cf7e7fe48dd7ca1de4636
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ETS2 CACNA1A NELL2

3.62e-04195323787e95fb59c40bba784544b662fac37606ae1427
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ETS2 HCK PRDM1

3.62e-0419532362dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 PPA1 ADAM23

3.68e-041963239afd0a7135028a446f06bb68f334e79b8f171b45
ToppCellPBMC-Control-Myeloid-cDC-cDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ETS2 NCKAP5 PPA1

3.68e-04196323553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCellPBMC-Control-Myeloid-cDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ETS2 NCKAP5 PPA1

3.68e-04196323e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCellPBMC-Control-Myeloid-cDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ETS2 NCKAP5 PPA1

3.68e-04196323d376168e15ec1cf618723259966c76be3698b9b0
ToppCellIPF-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

NELL2 ADAM23 PRDM1

3.68e-041963236e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCellControl-Myeloid-cDC|Control / Disease group, lineage and cell class

ETS2 NCKAP5 PPA1

3.68e-0419632385d92bc226cc28384c30991cc4ebb02ec2e3ec99
ToppCellCOPD-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

NELL2 ADAM23 PRDM1

3.68e-04196323c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCellPBMC-Control-Myeloid-cDC-cDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ETS2 NCKAP5 PPA1

3.68e-041963234a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETS2 ADAM23 WNT2

3.68e-0419632381900dcc9451ff6606ec940c16b559d73247590e
ToppCellnormal-na-Myeloid-conventional_dendritic_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 NCKAP5 PPA1

3.73e-0419732317c6d2a7baef6393c3e2d3e65cc924df22049eb0
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETS2 ADAM23 WNT2

3.73e-04197323d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCellMonocytes-cDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

ETS2 NCKAP5 HCK

3.73e-041973233388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ETS2 PPA1 HCK

3.73e-041973234f7c10a636646dfc82a84026c1b5a36603367abe
ToppCellnormal-na-Myeloid-conventional_dendritic_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 NCKAP5 PPA1

3.73e-041973239a0bcb055b1a5fd5439e4a0bf1742f009331df47
ToppCell(6)_Macrophage|World / shred on Cell_type and subtype

ETS2 NELL2 HCK

3.73e-04197323010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCellHealthy_donor-cDC|Healthy_donor / disease group, cell group and cell class (v2)

ETS2 NCKAP5 PPA1

3.73e-04197323b57a27e5b855bbdd1dfa352540599d260dc482aa
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETS2 ADAM23 WNT2

3.73e-04197323412091994196a06c2779b4c2cfed84be889a5f8d
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-Teffector/EM_CD4|bone_marrow / Manually curated celltypes from each tissue

NELL2 ADAM23 PRDM1

3.73e-0419732373a13d4dc76476f3a38b09b776779c5b7d67171f
ToppCelldistal-Hematologic-CD4+_Naive_T-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NELL2 CACNA1G PRDM1

3.79e-041983234db9eff17778ffc3f77c017ff64f55bc1626da24
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ETS2 PPA1 HCK

3.79e-04198323da36c1bb62fdd1da7aca9c5115432a87fb48adb0
ToppCellSepsis-URO-Lymphocyte-T/NK-CD8+_T_naive|URO / Disease, condition lineage and cell class

NELL2 PPA1 ADAM23

3.79e-04198323c07426d4119b53e58eb5f448ae364f47cac1fc5c
ToppCell(0)_Myeloid-(01)_Dendritic_cell-(010)_cDC|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)

ETS2 PPA1 HCK

3.79e-041983234abc274edac40f8836255fac2371ffd98a32cccd
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 ADAM23 TF

3.79e-0419832350dfe6efca76ea9683a19b6bff59cb5030d346f1
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-conventional_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 NCKAP5 PPA1

3.79e-04198323b0e090000d1cdee4628f4ab252f6b444658f80f5
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ETS2 NCKAP5 PPA1

3.79e-0419832399f98e240d81cfe5b485da2598f8392d7cbd9013
ToppCellSigmoid-Dendritic_cell-cycling_DCs|Sigmoid / Region, Cell class and subclass

ETS2 NCKAP5 HCK

3.85e-04199323bd6f8c0f79e9a94cc0f8c6105d38851463de821c
ToppCellSigmoid-(5)_Dendritic_cell-(52)_cycling_DCs|Sigmoid / shred on region, Cell_type, and subtype

ETS2 NCKAP5 HCK

3.85e-041993238ee78a39729633bcbb3ab17e1dfaca33f38db569
ToppCellTransverse-(5)_Dendritic_cell-(51)_cDC1|Transverse / shred on region, Cell_type, and subtype

NCKAP5 HCK TLR3

3.85e-0419932352dd1c4cd372f8ee515307a9200e357bb2145888
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NELL2 ADAM23 PRDM1

3.85e-04199323a1b127f12fa2057d6f2a976a139301a028a3f957
ToppCellSigmoid-(5)_Dendritic_cell-(50)_cDC2|Sigmoid / shred on region, Cell_type, and subtype

ETS2 NCKAP5 HCK

3.85e-04199323402af84db90d8a49d67cf44c24766aefb00fd716
ToppCell(5)_Dendritic_cell|World / shred on Cell_type and subtype

ETS2 NCKAP5 HCK

3.85e-04199323495de74a918c5c625a2d0ef120fe4162d4ce6e76
ToppCellSigmoid-Dendritic_cell-cDC2|Sigmoid / Region, Cell class and subclass

ETS2 NCKAP5 HCK

3.85e-04199323cd74db6db694b68f81dcf9d9342d125d00357ec1
DiseaseHerpetic Acute Necrotizing Encephalitis

TRAF3 TLR3

1.07e-055312C0001338
DiseaseHerpetic meningoencephalitis

TRAF3 TLR3

1.60e-056312C0019385
DiseaseHerpes encephalitis

TRAF3 TLR3

2.24e-057312C0276226
DiseaseAutistic Disorder

NSD1 KDM5B TF WNT2

1.56e-04261314C0004352
DiseaseAtaxia, Spinocerebellar

CACNA1A CACNA1G

5.87e-0434312C0087012
DiseaseSpinocerebellar Ataxia Type 2

CACNA1A CACNA1G

5.87e-0434312C0752121
DiseaseSpinocerebellar Ataxia Type 1

CACNA1A CACNA1G

5.87e-0434312C0752120
DiseaseSpinocerebellar Ataxia Type 5

CACNA1A CACNA1G

5.87e-0434312C0752123
DiseaseSpinocerebellar Ataxia Type 7

CACNA1A CACNA1G

5.87e-0434312C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

CACNA1A CACNA1G

5.87e-0434312C0752124
DiseaseSpinocerebellar Ataxia Type 4

CACNA1A CACNA1G

6.22e-0435312C0752122
Diseaseimmunoglobulin isotype switching measurement

TRAF3 MUTYH

9.83e-0444312EFO_0010128

Protein segments in the cluster

PeptideGeneStartEntry
MLSCLSGKPCDKNSG

CACNA1A

1761

O00555
LNMSSCPLDSKGKVC

ADAM23

731

O75077
CKSSKDGNSVMSPLF

ALPK2

876

Q86TB3
MGNTTSCCVSSSPKL

CCNY

1

Q8ND76
GSLDMPTCLKSSISC

CC2D2B

881

Q6DHV5
MGQCVTKCKNPSSTL

DCUN1D3

1

Q8IWE4
SLKCCSSDTKGSPLA

NSD1

811

Q96L73
CKDQTMKLVESSGCP

NELL2

361

Q99435
SSSPGPKKSDMCEGC

FLCN

71

Q8NFG4
CSIMPSGCASKTLLK

CFAP65

441

Q6ZU64
SSCSSKPNLDTMCKG

FAM135A

936

Q9P2D6
DDCSQSLCLNKPTMS

ETS2

316

P15036
AKCSCLTALDMTGKP

DIP2B

351

Q9P265
KTTCFMSAISCSCKP

KDM5B

696

Q9UGL1
DGLCQKLSVPCMSSK

HCK

231

P08631
SSCKISSPCLKADSG

CACNA1G

646

O43497
SCMNTTLSESPFKCD

PPA1

241

Q15181
MSGSCSSRKCFSVPA

KRTAP16-1

1

A8MUX0
KKSIPSSECSGCSNS

RSC1A1

231

Q92681
EDASCCSLKKDSNPM

TESMIN

196

Q9Y4I5
KLTSCASSCPLEMKL

NCKAP5

536

O14513
TCMGSKRSQVSSPCS

MUTYH

501

Q9UIF7
AAASMKDKACSPTSG

PRDM1

501

O75626
ADPSTKKANSCDMCG

ZNF132

106

P52740
EVKSCSCDPKKMGSA

WNT2

131

P09544
CMAALLSSSSPKCTA

TRAF3

76

Q13114
PFGMLCASSTTKCTV

TLR3

16

O15455
GSKKDSSLCKLCMGS

TF

506

P02787
CKASTPSMTNQCKET

ZDBF2

1586

Q9HCK1
NKCVSCMSEKPGSSV

NUP153

811

P49790
RCCSFKVPKSSMGAT

ZFYVE27

376

Q5T4F4
SPDCSMLCSAAGEKS

WSB2

206

Q9NYS7