Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscell adhesion mediated by integrin

PIEZO1 ITGAD ITGAL ITGB5 ITGB7 MMRN1 EFNA1 CCN3

8.97e-07911718GO:0033627
GeneOntologyBiologicalProcessT cell migration

ITGAL LRCH1 ITGB7 TMEM102 MED23 FUT7

5.77e-05811716GO:0072678
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

6.83e-0521712GO:0038099
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

6.83e-0521712GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

6.83e-0521712GO:1900123
GeneOntologyBiologicalProcesscell-cell adhesion

HSPD1 CYLD GP6 FLNA ZAN PIEZO1 HSPH1 PPARA ITGAD ITGAL ITGB5 ITGB7 TESPA1 MMRN1 CD93 MMP24 TENM3 IZUMO1 LRRC7 FUT7 PLXNB3 CCN3

8.59e-05107717122GO:0098609
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGAD ITGAL ITGB5 ITGB7 MMRN1 IZUMO1

9.85e-06591756GO:0098636
GeneOntologyCellularComponentintegrin complex

ITGAD ITGAL ITGB5 ITGB7

1.42e-04321754GO:0008305
DomainEGF_2

CNTNAP3B ZAN ADAM21 LRP1B PGAP6 ITGB5 ITGB7 MMRN1 CD93 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

4.42e-1026517317PS01186
DomainEGF_1

CNTNAP3B ZAN ADAM21 LRP1B PGAP6 ITGB5 ITGB7 MMRN1 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

2.03e-0925517316PS00022
DomainEGF-like_CS

ZAN ADAM21 LRP1B PGAP6 ITGB5 ITGB7 MMRN1 CD93 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

2.84e-0926117316IPR013032
DomainEGF

CNTNAP3B ZAN LRP1B PGAP6 ITGB5 MMRN1 CD93 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

5.26e-0923517315SM00181
DomainEGF_3

CNTNAP3B ZAN ADAM21 LRP1B PGAP6 MMRN1 CD93 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

5.26e-0923517315PS50026
DomainEGF-like_dom

CNTNAP3B ZAN ADAM21 LRP1B PGAP6 MMRN1 CD93 HHIP MFGE8 MEGF8 TENM3 SLIT1 DLL3 LRP2 FBN3

1.15e-0824917315IPR000742
DomainEGF

ZAN LRP1B ITGB5 MMRN1 CD93 MFGE8 SLIT1 DLL3 LRP2 FBN3

2.74e-0712617310PF00008
DomainEGF_extracell

LRP1B ITGB5 ITGB7 HHIP TENM3 DLL3 LRP2

1.32e-06601737IPR013111
DomainEGF_2

LRP1B ITGB5 ITGB7 HHIP TENM3 DLL3 LRP2

1.32e-06601737PF07974
DomainGrowth_fac_rcpt_

LRP1B CD93 IGFBP1 MEGF8 SLIT1 DLL3 LRP2 CCN2 FBN3 CCN3

1.96e-0615617310IPR009030
DomainTIL_dom

VWF ZAN KCP LRP2

6.62e-06141734IPR002919
DomainEGF_CA

LRP1B MMRN1 CD93 MEGF8 SLIT1 DLL3 LRP2 FBN3

1.81e-051221738SM00179
DomainVWFC_1

VWF ZAN KCP CCN2 CCN3

1.92e-05361735PS01208
DomainCTCK_1

VWF SLIT1 CCN2 CCN3

1.97e-05181734PS01185
DomainEGF-like_Ca-bd_dom

LRP1B MMRN1 CD93 MEGF8 SLIT1 DLL3 LRP2 FBN3

2.04e-051241738IPR001881
DomainVWFC_2

VWF ZAN KCP CCN2 CCN3

2.52e-05381735PS50184
DomainVWC

VWF ZAN KCP CCN2 CCN3

2.52e-05381735SM00214
Domain-

TRIM71 LRP1B HHIP TENM3 LRP2

2.87e-053917352.120.10.30
DomainVWF_dom

VWF ZAN KCP CCN2 CCN3

4.15e-05421735IPR001007
DomainCT

VWF SLIT1 CCN2 CCN3

4.57e-05221734SM00041
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1B MMRN1 CD93 MEGF8 SLIT1 LRP2 FBN3

5.84e-051061737IPR000152
DomainPSI_integrin

ITGB5 ITGB7 MEGF8

6.30e-0591733PF17205
DomainIntegin_beta_N

ITGB5 ITGB7 MEGF8

6.30e-0591733IPR033760
Domain6-blade_b-propeller_TolB-like

TRIM71 LRP1B HHIP TENM3 LRP2

6.49e-05461735IPR011042
DomainIntegrin_dom

ITGAD ITGAL ITGB5 ITGB7

7.73e-05251734IPR032695
DomainCys_knot_C

VWF SLIT1 CCN2 CCN3

7.73e-05251734IPR006207
DomainCTCK_2

VWF SLIT1 CCN2 CCN3

7.73e-05251734PS01225
DomainLRDF

LEFTY2 LEFTY1

8.53e-0521732IPR003942
DomaincEGF

LRP1B CD93 LRP2 FBN3

9.06e-05261734PF12662
DomaincEGF

LRP1B CD93 LRP2 FBN3

9.06e-05261734IPR026823
DomainInsulin_GF-bd_Cys-rich_CS

IGFBP1 CCN2 CCN3

1.22e-04111733IPR017891
DomainVWC

VWF KCP CCN2 CCN3

1.22e-04281734PF00093
DomainIGFBP_N_1

IGFBP1 CCN2 CCN3

1.62e-04121733PS00222
Domain-

HSPA4L HSPH1 HSPA4

1.62e-041217332.60.34.10
DomainHSP70_peptide-bd

HSPA4L HSPH1 HSPA4

1.62e-04121733IPR029047
Domain-

NLRP11 LRWD1 LRRC38 DMAC2 LINGO3 TPBGL LRCH1 SLIT1 TONSL LRCH4 LRRC7

2.07e-04321173113.80.10.10
Domain-

HSPA4L HSPH1 HSPA4

2.09e-041317331.20.1270.10
DomainUnchr_dom_Cys-rich

VWF ZAN KCP

2.09e-04131733IPR014853
DomainHeat_shock_70_CS

HSPA4L HSPH1 HSPA4

2.09e-04131733IPR018181
DomainHSP70_C

HSPA4L HSPH1 HSPA4

2.09e-04131733IPR029048
DomainC8

VWF ZAN KCP

2.09e-04131733SM00832
DomainLeu-rich_rpt

NLRP11 LRWD1 LRRC38 LINGO3 TPBGL LRCH1 SLIT1 TONSL LRCH4 LRRC7

2.24e-0427117310IPR001611
DomainLRR_TYP

LRWD1 LRRC38 LINGO3 TPBGL LRCH1 SLIT1 LRCH4 LRRC7

2.49e-041771738SM00369
DomainLeu-rich_rpt_typical-subtyp

LRWD1 LRRC38 LINGO3 TPBGL LRCH1 SLIT1 LRCH4 LRRC7

2.49e-041771738IPR003591
DomainL_dom-like

NLRP11 LRWD1 LRRC38 DMAC2 LINGO3 TPBGL LRCH1 SLIT1 TONSL LRCH4 LRRC7

2.50e-0432817311IPR032675
DomainEGF_Ca-bd_CS

LRP1B CD93 MEGF8 SLIT1 LRP2 FBN3

2.85e-04971736IPR018097
DomainEGF_CA

LRP1B CD93 MEGF8 SLIT1 LRP2 FBN3

3.18e-04991736PS01187
DomainVWF_A

VWA5B2 VWF ITGAD ITGAL ITGB5 ITGB7

3.18e-04991736IPR002035
DomainVWF_type-D

VWF ZAN KCP

4.00e-04161733IPR001846
DomainVWFD

VWF ZAN KCP

4.00e-04161733PS51233
DomainVWD

VWF ZAN KCP

4.00e-04161733SM00216
DomainHSP70

HSPA4L HSPH1 HSPA4

4.00e-04161733PF00012
DomainVWD

VWF ZAN KCP

4.00e-04161733PF00094
DomainHSP70_2

HSPA4L HSPH1 HSPA4

4.83e-04171733PS00329
DomainHSP70_1

HSPA4L HSPH1 HSPA4

4.83e-04171733PS00297
DomainHSP70_3

HSPA4L HSPH1 HSPA4

4.83e-04171733PS01036
DomainIB

IGFBP1 CCN2 CCN3

5.75e-04181733SM00121
DomainHsp_70_fam

HSPA4L HSPH1 HSPA4

5.75e-04181733IPR013126
DomainVWC_out

VWF ZAN KCP

6.79e-04191733SM00215
DomainPSI

ITGB5 ITGB7 MEGF8 PLXNB3

7.23e-04441734IPR016201
DomainIGFBP

IGFBP1 CCN2 CCN3

7.93e-04201733PF00219
DomainIGFBP-like

IGFBP1 CCN2 CCN3

7.93e-04201733IPR000867
DomainIGFBP_N_2

IGFBP1 CCN2 CCN3

7.93e-04201733PS51323
DomainIGFBP_CNN

CCN2 CCN3

8.38e-0451732IPR012395
DomainPSI

ITGB5 ITGB7 MEGF8 PLXNB3

8.57e-04461734SM00423
DomainVWFA

VWF ITGAD ITGAL ITGB5 ITGB7

9.88e-04821735PS50234
DomainLRR_8

LRRC38 LINGO3 TPBGL LRCH1 SLIT1 LRCH4 LRRC7

1.09e-031711737PF13855
DomainVWA

VWF ITGAD ITGAL ITGB5 ITGB7

1.10e-03841735SM00327
DomainEGF_CA

LRP1B CD93 MEGF8 LRP2 FBN3

1.22e-03861735PF07645
DomainIntegrin_b_cyt

ITGB5 ITGB7

1.25e-0361732SM01241
DomainIntegrin_b_cyt

ITGB5 ITGB7

1.25e-0361732PF08725
DomainIntegrin_bsu_cyt_dom

ITGB5 ITGB7

1.25e-0361732IPR014836
DomainIntegrin_B_tail

ITGB5 ITGB7

1.74e-0371732SM01242
DomainIntegrin_bsu_tail

ITGB5 ITGB7

1.74e-0371732IPR012896
DomainIntegrin_B_tail

ITGB5 ITGB7

1.74e-0371732PF07965
DomainhEGF

SLIT1 DLL3 FBN3

2.16e-03281733PF12661
DomainINB

ITGB5 ITGB7

2.30e-0381732SM00187
DomainIntegrin_bsu_VWA

ITGB5 ITGB7

2.30e-0381732IPR002369
DomainIntegrin_beta

ITGB5 ITGB7

2.30e-0381732PF00362
DomainASX_HYDROXYL

LRP1B CD93 MEGF8 LRP2 FBN3

2.38e-031001735PS00010
DomainLRR

LRWD1 LRRC38 LINGO3 LRCH1 SLIT1 LRCH4 LRRC7

2.73e-032011737PS51450
DomainIntegrin_bsu

ITGB5 ITGB7

2.94e-0391732IPR015812
DomainINTEGRIN_BETA

ITGB5 ITGB7

2.94e-0391732PS00243
DomainIG_FLMN

FLNA TRIM71

3.66e-03101732SM00557
DomainVPS9

ALS2CL RIN2

3.66e-03101732PS51205
DomainNHL_repeat

TRIM71 LRP1B

3.66e-03101732IPR001258
DomainNHL

TRIM71 LRP1B

3.66e-03101732PF01436
DomainVPS9

ALS2CL RIN2

3.66e-03101732PF02204
DomainVPS9

ALS2CL RIN2

3.66e-03101732IPR003123
DomainTPR_7

NOXA1 TONSL

3.66e-03101732PF13176
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

VWF P3H3 ITGAD ITGAL ITGB5 ITGB7 CAPN10 MMP24 ADAMTS14 FBN3 CRTAP

5.82e-0530012211M610
PathwayPID_INTEGRIN_CS_PATHWAY

ITGAD ITGAL ITGB5 ITGB7

6.89e-05261224M47
PathwayREACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION

GP6 FLNA VWF DGKQ F2 F2R MMRN1 LEFTY2 LEFTY1 DAGLA

7.83e-0525712210MM15454
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 FLNA SPIRE2 LRWD1 CTC1 LONRF1 PIEZO1 SREBF1 DGKQ PPARA ZNF865 ITGB5 NSD3 PER2 SLC16A5 MEGF8 IFRD2 IRS2 LTK HERC1 MED12

2.20e-0711051762135748872
Pubmed

Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.

LEFTY2 LEFTY1 LRP2

4.39e-067176332876567
Pubmed

A novel HSF1-mediated death pathway that is suppressed by heat shock proteins.

HSPA4L HSPH1 HSPA4

4.39e-067176317024176
Pubmed

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.

HSPA4L HSPH1 DNAJB4 HSPA4

5.21e-0623176421231916
Pubmed

Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.

HSPA4L HSPH1 DNAJB4 HSPA4

7.38e-0625176427483141
Pubmed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.

ITGAD ITGAL ITGB5 ITGB7

1.02e-0527176431541017
Pubmed

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

HSPA4L HSPH1 HSPA4

1.49e-0510176319171884
Pubmed

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

HSPD1 HSPA4L HSPH1 HSPA4

1.57e-0530176425864199
Pubmed

Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway.

F2 F2R

2.55e-052176229141676
Pubmed

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome.

HSPD1 HSPA4

2.55e-052176224327239
Pubmed

Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear.

VWF MMRN1

2.55e-052176219175495
Pubmed

LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues.

PPARA PLIN5

2.55e-052176217234449
Pubmed

Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.

HSPD1 HSPA4

2.55e-052176223807299
Pubmed

Atherosclerosis, myocardial infarction and primary hemostasis: Impact of platelets, von Willebrand factor and soluble glycoprotein VI.

GP6 VWF

2.55e-052176231276978
Pubmed

Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes.

SREBF1 PPARA

2.55e-052176212736163
Pubmed

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.

GP6 VWF

2.55e-052176225051961
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

2.55e-052176220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

2.55e-052176210053005
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

2.55e-052176211100524
Pubmed

Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion.

SREBF1 PPARA

2.55e-052176219733654
Pubmed

Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis.

F2 F2R

2.55e-052176215755869
Pubmed

Flow and delta-P dictate where thrombin, fibrin, and von Willebrand Factor will be found.

VWF F2

2.55e-052176227207416
Pubmed

Urinary mRNA expression of CCN2/CCN3 as a noninvasive marker for monitoring glomerular structure changes in nondiabetic chronic kidney disease.

CCN2 CCN3

2.55e-052176223061738
Pubmed

TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel.

ATP5MC1 TMEM70

2.55e-052176233359711
Pubmed

A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation.

F2 F2R

2.55e-052176223406164
Pubmed

The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.

FLNA ITGB7

2.55e-052176219699211
Pubmed

Early changes of the heat-shock protein 60 to 70 ratio as prediction of miscarriage in pregnancy.

HSPD1 HSPA4

2.55e-052176230614112
Pubmed

Differential Ca(2+)responses induced by thrombin and thrombin-receptor agonist peptides in HSY-EA1 cells.

F2 F2R

2.55e-052176214642534
Pubmed

The cleaved peptide of PAR1 is a more potent stimulant of platelet-endothelial cell adhesion than is thrombin.

F2 F2R

2.55e-052176212563219
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

2.55e-052176233409963
Pubmed

Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia.

HSPD1 HSPA4

2.55e-052176219205928
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

2.55e-052176217038673
Pubmed

Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis.

F2 F2R

2.55e-052176233086557
Pubmed

Prognostic value of CCN3 in osteosarcoma.

CCN2 CCN3

2.55e-052176218245529
Pubmed

Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.

LEFTY2 LEFTY1

2.55e-052176221401636
Pubmed

Thrombin generation in the presence of platelets is sensitive to the activation status of von Willebrand factor.

VWF F2

2.55e-052176225274249
Pubmed

Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation.

F2 F2R

2.55e-052176227108773
Pubmed

Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis.

SREBF1 PPARA

2.55e-052176216106047
Pubmed

Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein.

CCN2 CCN3

2.55e-052176221209863
Pubmed

Heat shock proteins 60 and 70 are associated with long-term outcome of T1-stage high-grade urothelial tumors of the bladder treated with intravesical Bacillus Calmette-Guérin immunotherapy.

HSPD1 HSPA4

2.55e-052176230337218
Pubmed

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation.

F2 F2R

2.55e-05217629038223
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

2.55e-052176232745796
Pubmed

Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes.

HSPA4L HSPA4

2.55e-052176210524232
Pubmed

Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.

ITGB5 MFGE8

2.55e-052176217620600
Pubmed

GPIb potentiates GPVI-induced responses in human platelets.

GP6 VWF

2.55e-052176215203711
Pubmed

N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization.

F2 F2R

2.55e-052176220368337
Pubmed

Thrombin-mediated in vitro processing of pro-von Willebrand factor.

VWF F2

2.55e-052176211776313
Pubmed

Heat shock proteins in children and young adults on chronic hemodialysis.

HSPD1 HSPA4

2.55e-052176219475432
Pubmed

Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha).

SREBF1 PPARA

2.55e-052176221540177
Pubmed

Free Fatty Acids Increase Intracellular Lipid Accumulation and Oxidative Stress by Modulating PPARα and SREBP-1c in L-02 Cells.

SREBF1 PPARA

2.55e-052176227270405
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

2.55e-052176234910522
Pubmed

OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization.

PPARA PLIN5

2.55e-052176217130488
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

2.55e-052176224147624
Pubmed

The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

VWF MMRN1

2.55e-052176227052467
Pubmed

Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1.

F2 F2R

2.55e-052176223204166
Pubmed

The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells.

VWF F2

2.55e-052176220505748
Pubmed

Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation.

HSPD1 HSPA4

2.55e-052176217553457
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

2.55e-052176220171171
Pubmed

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

F2 F2R

2.55e-05217621672265
Pubmed

Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.

F2 F2R

2.55e-052176212023853
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

2.55e-05217629496783
Pubmed

G protein-coupled receptors: functional and mechanistic insights through altered gene expression.

F2R EDNRB

2.55e-05217629457168
Pubmed

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

LEFTY2 LEFTY1

2.55e-052176229268772
Pubmed

Physical mapping of human loci homologous to the chicken nov proto-oncogene.

CCN2 CCN3

2.55e-05217621334251
Pubmed

Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor.

F2 F2R

2.55e-05217629058715
Pubmed

PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

F2 F2R

2.55e-052176222009534
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

2.55e-052176211687802
Pubmed

Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair.

F2 F2R

2.55e-052176226475502
Pubmed

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.

LEFTY2 LEFTY1

2.55e-052176229230527
Pubmed

Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells.

F2 F2R

2.55e-052176223919450
Pubmed

Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.

LEFTY2 LEFTY1

2.55e-052176229286065
Pubmed

Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol.

F2R DAGLA

2.55e-052176221414931
Pubmed

Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.

LEFTY2 LEFTY1

2.55e-052176215640253
Pubmed

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling.

FLNA PIEZO1

2.55e-052176226526998
Pubmed

Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.

FLNA ITGB7

2.55e-052176211781567
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

VWA5B2 LMTK3 PARP10 SLC18A3 MRGPRG MKI67 LTK ZNF282

2.66e-05233176837704626
Pubmed

Heat-shock protein HSPA4 is required for progression of spermatogenesis.

HSPA4L HSPH1 HSPA4

2.71e-0512176321487003
Pubmed

Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse.

EDNRB LEFTY2 LEFTY1

2.71e-0512176310964471
Pubmed

Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.

HSPA4L HSPH1 HSPA4

2.71e-0512176323980576
Pubmed

Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin.

GP6 VWF F2

3.51e-0513176318848323
Pubmed

Node and midline defects are associated with left-right development in Delta1 mutant embryos.

LEFTY2 LEFTY1 DLL3

3.51e-0513176312441287
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

LEFTY2 LEFTY1 CCN2 ADAMTS14 CCN3

4.06e-0575176520637190
Pubmed

Structure, function, and activator-induced conformations of the CRSP coactivator.

SREBF1 MED23 MED12

4.45e-0514176311834832
Pubmed

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.

SREBF1 PPARA MKI67

4.45e-0514176325249504
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CYLD TSPOAP1 PEG3 PER2 MEGF8 TENM3 SLIT1 LRRC7 VPS13B PLXNB3

4.67e-054071761012693553
Pubmed

Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.

TENM3 SLC18A3 MKI67

5.54e-0515176331812516
Pubmed

Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry.

LEFTY2 LEFTY1 MKI67

5.54e-0515176321831921
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

PEG3 NOXA1 SREBF1 TXNDC11 USP6 MEGF8 PTPRN SLIT1 LRP2 NIT1 PPP6R2 HSPA4

6.84e-056081761216713569
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

HSPA4L ZC3H13 HSPH1 RPS8 PRDX3 MACROD2 HSPA4

6.90e-05197176720811636
Pubmed

Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin.

FLNA ITGB7

7.61e-053176221524097
Pubmed

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling.

F2 F2R

7.61e-053176215769747
Pubmed

Nodal and lefty signaling regulates the growth of pancreatic cells.

LEFTY2 LEFTY1

7.61e-053176218393305
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

7.61e-053176230801007
Pubmed

A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.

F2 F2R

7.61e-053176220164183
Pubmed

Engineering thrombin for selective specificity toward protein C and PAR1.

F2 F2R

7.61e-053176220404340
Pubmed

Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.

LEFTY2 LEFTY1

7.61e-053176216141390
Pubmed

IFT46 plays an essential role in cilia development.

LEFTY2 LEFTY1

7.61e-053176225722189
Pubmed

Association of thrombin generation potential with platelet PAR-1 regulation and P-selectin expression in patients on dual antiplatelet therapy.

F2 F2R

7.61e-053176224435325
Pubmed

Fatty acids regulate perilipin5 in muscle by activating PPARδ.

PPARA PLIN5

7.61e-053176223606724
Pubmed

Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

ITGB5 CCN3

7.61e-053176215611078
GeneFamilyHeat shock 70kDa proteins

HSPA4L HSPH1 HSPA4

1.72e-04171183583
GeneFamilyCYR61/CTGF/NOV matricellular proteins

CCN2 CCN3

6.23e-04611821046
GeneFamilyCD molecules|Integrin beta subunits

ITGB5 ITGB7

1.48e-03911821159
GeneFamilyVPS9 domain containing

ALS2CL RIN2

1.84e-03101182928
CoexpressionNABA_MATRISOME

VWA5B2 GPC1 VWF P3H3 ADAM21 KCP F2 CXCL2 MMRN1 LEFTY2 MMP24 LEFTY1 HHIP MFGE8 IGFBP1 MEGF8 FRZB SLIT1 CCN2 ADAMTS14 FBN3 PLXNB3 CCN3

4.29e-07102617623M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

VWA5B2 VWF KCP MMRN1 MFGE8 IGFBP1 SLIT1 CCN2 FBN3 CCN3

8.98e-0719617610M3008
CoexpressionNABA_MATRISOME

VWA5B2 GPC1 VWF P3H3 ADAM21 KCP F2 CXCL2 MMRN1 LEFTY2 MMP24 LEFTY1 HHIP MFGE8 IGFBP1 MEGF8 FRZB SLIT1 CCN2 ADAMTS14 PLXNB3 CCN3

1.22e-06100817622MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

VWA5B2 VWF KCP MMRN1 MFGE8 IGFBP1 SLIT1 CCN2 CCN3

6.12e-061911769MM17059
CoexpressionNABA_CORE_MATRISOME

VWA5B2 VWF KCP MMRN1 MFGE8 IGFBP1 SLIT1 CCN2 FBN3 CCN3

1.80e-0527517610M5884
CoexpressionBERENJENO_TRANSFORMED_BY_RHOA_UP

HSPD1 GPC1 HSPA4L CIP2A HSPH1 CXCL2 CD93 RFLNB IFRD2 MKI67 CCN2 SLC35E4 CTPS1 HSPA4

3.39e-0557117614MM1100
CoexpressionNABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR

F2 MMRN1 LEFTY1 MFGE8 MEGF8

4.81e-05591765M47989
CoexpressionGSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_DN

ALS2CL ITGB5 EDNRB GGT5 RFLNB INSC PPP6R2 KLRG1

6.28e-051991768M2921
CoexpressionGSE15750_WT_VS_TRAF6KO_DAY10_EFF_CD8_TCELL_UP

LONRF1 DGKQ ALS2CL COQ10A RFLNB RIN2 GEMIN4 CCN2

6.50e-052001768M3573
CoexpressionGSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_PIOGLITAZONE_TREATED_UP

PDE3A DGKQ TMPRSS5 PPARA ITGAL ITGB7 SLC18A3 CCN2

6.50e-052001768M8975
CoexpressionGSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP

FLNA ITGB7 NSD3 SLC15A4 PLIN5 DDX41 DKK4 VPS13B

6.50e-052001768M5772
CoexpressionAIZARANI_LIVER_C10_MVECS_1

CNTNAP3B VWF F2R EDNRB MMRN1 SHROOM4 CD93 TMTC1 CCN2

9.03e-052691769M39114
CoexpressionNABA_CORE_MATRISOME

VWA5B2 VWF KCP MMRN1 MFGE8 IGFBP1 SLIT1 CCN2 CCN3

9.29e-052701769MM17057
CoexpressionBERENJENO_TRANSFORMED_BY_RHOA_UP

HSPD1 GPC1 HSPA4L CIP2A HSPH1 CD93 RFLNB IFRD2 MKI67 CCN2 SLC35E4 CTPS1 HSPA4

9.38e-0555017613M16189
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ST6GALNAC1 VWF SRARP F2R GGT5 MMRN1 CD93 IGFBP1 EXOC3L1 CCN2

7.77e-091981781072e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF HSPA4L F2R SHROOM4 CD93 TMTC1 RFLNB RIN2 EXOC3L1

6.13e-081851789808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

F2R EDNRB GGT5 HHIP MFGE8 INSC FRZB CCN2 ADAMTS14

6.42e-081861789d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

VWF PIEZO1 SRARP LYPD2 MMRN1 SHROOM4 CD93 EXOC3L1

6.59e-08133178829b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CCNJL SLC27A6 ITGB7 HHIP NXF3 CTPS1 SPOCD1 PLXNB3

8.30e-08137178880f1a6cfb48ccfba1c3545fdcd5fcb3157272aca
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP F2R GGT5 MMRN1 CD93 IGFBP1 RFLNB CCN2

1.05e-0719717899244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ST6GALNAC1 VWF SRARP GGT5 MMRN1 CD93 IGFBP1 RFLNB CCN2

1.09e-071981789218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP F2R GGT5 MMRN1 CD93 IGFBP1 RFLNB CCN2

1.09e-0719817897cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP GGT5 SHROOM4 CD93 EFNA1 IGFBP1 EXOC3L1 CCN2

1.14e-0719917890602e2b2aa56d106da63bd342a38bef437b4d496
ToppCellfacs-MAT-Fat-3m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPC1 LMTK3 ITGAL ITGB7 SLC25A43 TONSL ADAMTS14 KLRG1

2.05e-071541788391d40ef902773ffe832a50a14d35d31c56d3723
ToppCellfacs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMTK3 TXNDC11 SLC16A5 PTPRN DLL3 IZUMO1 TMEM102 GABRA4

4.97e-071731788295bfe1efa648173c2d5981025bc61c576baf53f
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF SRARP EDNRB MMRN1 PLIN5 EXOC3L1 FBN3 PLXNB3

5.91e-071771788b1775e05c28883a15c56628028770bc59d3233fb
ToppCelldroplet-Liver-nan-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC27A6 CTC1 KCP ITGAL HHIP SLIT1 DAGLA

8.08e-07127178739fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Platelets-Platelets|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GP6 F2R ITGB5 TESPA1 MMRN1 MKI67 PLXNB3

8.08e-07127178729d0b078b9fb151b2689263828a0a2f178196d16
ToppCellLPS-IL1RA-Hematopoietic_Meg-Ery-Platelets|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GP6 F2R ITGB5 TESPA1 MMRN1 MKI67 PLXNB3

8.08e-071271787041fb924aa2138a86612e07a9a5759cbbe2446e0
ToppCellEndothelial-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CNTNAP3B VWF DNAJB4 F2R MMRN1 CD93 TMTC1 CCN2

8.25e-071851788ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCellEndothelial-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

CNTNAP3B VWF DNAJB4 F2R MMRN1 CD93 TMTC1 CCN2

8.25e-071851788dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A VWF F2R LRCH1 LRP1B CD93 TMTC1 CCN3

8.59e-0718617882d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells-Tumor_ECs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

VWF SRARP EDNRB GGT5 MMRN1 SHROOM4 CD93 TMTC1

8.95e-071871788be5f8c5802b0fa8cc1e274fdf06b13eb8ceb8ad4
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF F2R LRP1B MMRN1 SHROOM4 CD93 TMTC1 EXOC3L1

1.09e-06192178852acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PDE3A VWF LYPD2 CXCL2 LRP1B ITGB5 CD93 CCN2

1.09e-0619217887e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

GPC1 PEG3 RPS8 TMPRSS5 MFGE8 TENM3 FRZB CCN2

1.13e-06193178852f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC27A6 ITGB7 LRCH4 PRDM13 SPOCD1 PLXNB3

1.19e-06851786159b3ac93490c3e4918ea61f8ede7add9e63ca40
ToppCellmetastatic_Brain-Endothelial_cells-Tumor_ECs|metastatic_Brain / Location, Cell class and cell subclass

VWF SRARP GGT5 MMRN1 SHROOM4 CD93 RFLNB CCN2

1.37e-0619817885e274f29cc796dae7d64d6035e904816c25f9914
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ST6GALNAC1 VWF SRARP GGT5 MMRN1 CD93 IGFBP1 CCN2

1.37e-061981788e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCellmetastatic_Brain-Endothelial_cells|metastatic_Brain / Location, Cell class and cell subclass

VWF SRARP GGT5 MMRN1 SHROOM4 CD93 RFLNB CCN2

1.37e-06198178897ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP GGT5 CD93 EFNA1 IGFBP1 EXOC3L1 CCN2

1.43e-061991788463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPC1 P3H3 RPS8 MFGE8 TENM3 FRZB CCN2 CRTAP

1.48e-062001788be527df943a8cedc6452ecef3cafc282db34ceb8
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWF F2R CXCL2 MMRN1 SHROOM4 CD93 TMTC1 CCN2

1.48e-062001788e6d36be0c4c569e27303bb4e4f34cd2187e9759d
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPC1 P3H3 RPS8 MFGE8 TENM3 FRZB CCN2 CRTAP

1.48e-062001788d254f6634895486f81d7a8b6f006fbc2679eaa5b
ToppCellParenchyma_COVID-19-Endothelial-TX-Macrophages|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

VWF F2R CXCL2 MMRN1 SHROOM4 CD93 TMTC1 CCN2

1.48e-062001788c0c51719cf81512c50bfcc2fed883c867e522d2a
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWF F2R CXCL2 MMRN1 SHROOM4 CD93 TMTC1 CCN2

1.48e-062001788758840c31f2ddd7ccf7bf13252ebb48d33e89479
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWF F2R CXCL2 MMRN1 SHROOM4 CD93 TMTC1 CCN2

1.48e-062001788c37fe06a94e5779c56e01389869bb432d3bbaebc
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPC1 P3H3 RPS8 MFGE8 TENM3 FRZB CCN2 CRTAP

1.48e-0620017888e41a484038216f0c2ad258fd46c0e702a4bb8bf
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPC1 P3H3 RPS8 MFGE8 TENM3 FRZB CCN2 CRTAP

1.48e-062001788c935caef2988f165e96d8f1ef99ae8963ab9377f
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1|Thalamus / BrainAtlas - Mouse McCarroll V32

CCNJL TMPRSS5 ITGAD ITGB7 SYTL5 CTPS1 PLXNB3

2.15e-061471787a21b63d0d3aec9ffadf3fac833a0a24da58a95bf
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPC1 ITGAL CXCL2 ITGB7 CD93 MKI67 LRP2

2.81e-0615317870ef7c45cdd854c79e527006034029767f8e108b2
ToppCellHealthy_Control-Myeloid-Macrophages-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

GPR27 DUSP4 ITGAD F2R TESPA1 RFLNB KLRG1

3.94e-061611787d0482666479530cd2fd0d229cbb59a1d79839477
ToppCellLAM-Lymphoid-pDC|LAM / Condition, Lineage and Cell class

DRD4 TMEM132B ARL5C RFLNB SLC15A4 LTK FUT7

3.94e-061611787bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZAN ADAM21 LEFTY2 IGFBP1 LRP2

4.56e-06611785fec6c9a4e12c260338856567bf547f914f473dbb
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZAN ADAM21 LEFTY2 IGFBP1 LRP2

4.56e-0661178506aab3f1743ced1e46d22f0310f1cdb70c7a108e
ToppCellfacs-Lung-nan-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VWF SHROOM4 RFLNB CCN2 SPIDR CTPS1

5.63e-06170178767d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3|GI_small-bowel / Manually curated celltypes from each tissue

SHANK1 PEG3 CXCL2 MFGE8 SYTL5 FRZB CCN3

5.63e-06170178797df5ffb328196c46568975d2d97722bcc753bf5
ToppCellfacs-Lung-nan-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VWF SHROOM4 RFLNB CCN2 SPIDR CTPS1

5.63e-0617017878e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 TMEM241 ITGAL PGAP6 ITGB7 ARL5C PER2

5.85e-061711787e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA EDNRB LEFTY2 HHIP MACROD2 CCN2 PLXNB3

6.32e-061731787f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGAD GGT5 LEFTY1 HHIP FRZB CCN2 CCN3

6.56e-06174178795464817adef5ad2038bbf542f315756b7ad862e
ToppCell10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early|lymph-node_spleen / Manually curated celltypes from each tissue

GP6 PDE3A VWF PTPRN NXF3 SPOCD1 PLXNB3

7.07e-06176178750fe3fd862dd6a6550ebb8c27f337cde468efedc
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B VWF MMRN1 SHROOM4 TMTC1 RIN2 CCN2

8.18e-06180178727e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell3'_v3-Lung-Myeloid_Dendritic-pDC|Lung / Manually curated celltypes from each tissue

DRD4 ZAN TMEM132B ARL5C HHIP SLC15A4 LTK

8.49e-0618117873d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCellInfluenza_Severe-Platelet|Influenza_Severe / Disease group and Cell class

GP6 PDE3A ITGB5 MMRN1 LEFTY1 PTPRN SPOCD1

8.49e-0618117874d037b098bb6f780ed8b15c0ec23a6f4d86bf45a
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

VWF SRARP GGT5 MMRN1 SHROOM4 CD93 TMTC1

8.80e-061821787d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CNTNAP3B LRRC38 HSPH1 DNAJB4 EDNRB MMRN1 TENM3

8.80e-06182178753c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

GPR27 SREBF1 TRIM71 GGT5 SYTL5 LRCH4

8.86e-0612017867f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF F2R MMRN1 CD93 TMTC1 RFLNB IZUMO1

9.12e-061831787dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF F2R MMRN1 CD93 TMTC1 RFLNB IZUMO1

9.12e-0618317874759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCellCOPD-Endothelial-VE_Venous|COPD / Disease state, Lineage and Cell class

CNTNAP3B VWF MMRN1 SHROOM4 CD93 TMTC1 CCN2

9.45e-06184178744d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCellmegakaryocytic|World / Lineage and Cell class

GP6 PDE3A VWF ITGB5 MMRN1 LEFTY1 SPOCD1

9.45e-061841787b1c630ca2189d9d49402a5621b57618976fbea5c
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EDNRB GGT5 HHIP MFGE8 IGFBP1 FRZB CCN2

9.78e-061851787e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EDNRB GGT5 HHIP MFGE8 IGFBP1 FRZB CCN2

9.78e-0618517879d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GP6 PDE3A ITGB5 MMRN1 LEFTY1 PTPRN SPOCD1

1.01e-051861787107bc473f5e57238390f8e0ab9f7263a8f93948c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWA5B2 VWF SRARP CD93 IGFBP1 RFLNB CCN2

1.01e-051861787a906020a8df6fcca474b278f746c553b177a56b4
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GP6 PDE3A ITGB5 MMRN1 LEFTY1 PTPRN SPOCD1

1.01e-05186178713a9ddcf93b0c4319ab9d484af5e2056e9754caa
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPC1 F2R EDNRB HHIP INSC FRZB CRTAP

1.01e-051861787360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell367C-Endothelial_cells-Endothelial-D|367C / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3B VWF MMRN1 SHROOM4 CD93 EFNA1 CCN2

1.05e-0518717871342bc614bc4045263c2eb0a535a1dd6c64e7abe
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|tumor_Lung / Location, Cell class and cell subclass

CNTNAP3B VWF LRRC38 EDNRB MMRN1 TENM3 EXOC3L1

1.05e-05187178787ecdc5f24aced95a37e653429f0fc493ff4aa3e
ToppCell367C-Endothelial_cells-Endothelial-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3B VWF MMRN1 SHROOM4 CD93 EFNA1 CCN2

1.05e-0518717877aa206262b14b9f2aaa99e59da38b96c3594d2c9
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PIEZO1 ITGB7 TXNDC11 RIN2 PRDX3 MKI67 LTK

1.09e-05188178734873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

VWF EDNRB SHROOM4 CD93 KLHL5 TMTC1 RIN2

1.09e-0518817873953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellCOVID-19-kidney-T-cells-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPD1 CYLD DUSP4 HSPH1 ITGAL TESPA1 MKI67

1.09e-05188178715484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCNJL PDE3A VWF OTUD1 PEG3 F2R EDNRB

1.12e-0518917878e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FLNA EDNRB LEFTY2 HHIP TMTC1 LRRC7 ADAMTS14

1.12e-051891787da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCellfacs-Trachea-nan-18m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF EDNRB MMRN1 CD93 RFLNB IZUMO1 EXOC3L1

1.12e-0518917875ced78f4b5c276b1bab24df807c00cf5ac8ed3d4
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A VWF DUSP4 F2R SHROOM4 CD93 TMTC1

1.12e-051891787b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellfacs-Trachea-nan-18m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF EDNRB MMRN1 CD93 RFLNB IZUMO1 EXOC3L1

1.12e-0518917872105d8b011b93a460237e00bc029efd7762dc8d5
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCNJL PDE3A VWF OTUD1 PEG3 F2R EDNRB

1.12e-051891787fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCellfacs-Trachea-nan-18m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF EDNRB MMRN1 CD93 RFLNB IZUMO1 EXOC3L1

1.12e-051891787100eda87ac9c38dddcfa58408b057867a1738acb
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF CXCL2 MMRN1 CD93 EFNA1 IGFBP1 EXOC3L1

1.12e-051891787a34f008dfcee4012977bbc5b60de6f0329ca2f65
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF P3H3 F2R EDNRB CD93 EFNA1 IZUMO1

1.16e-0519017877068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF LYPD2 CXCL2 MMRN1 CD93 EXOC3L1 KLRG1

1.16e-05190178792fdfed12061ee9f6c7171cf8a7f3344921f2d40
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP MMRN1 CD93 IGFBP1 CCN2 CCN3

1.16e-05190178706bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellMegakaryocytic-erythropoietic-Megakaryo-cells|World / Lineage, cell class and subclass

GP6 PDE3A F2R ITGB5 MMRN1 PTPRN SPOCD1

1.16e-05190178772b61a12ccea506272ce9cef9051aa2612e6ce57
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|343B / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3B VWF F2R CXCL2 CD93 TMTC1 CCN2

1.20e-05191178727a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|343B / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3B VWF F2R CXCL2 CD93 TMTC1 CCN2

1.20e-0519117871dfcff08e01e6a695953334342bcfde04ba005ad
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature3_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

VWF LYPD2 GGT5 MMRN1 CD93 EFNA1 EXOC3L1

1.25e-0519217877dbe3117a0f58ff2e838963d49f788a59a4351d7
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF F2R LRP1B MMRN1 CD93 TMTC1 EXOC3L1

1.25e-05192178781baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCelldroplet-Kidney-nan-3m-Endothelial-fenestrated_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F2R EDNRB CD93 MFGE8 EFNA1 RFLNB EXOC3L1

1.25e-05192178785be54c2cba8eab4c6ef2a85a526f7a9db4cfe73
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F2R EDNRB CD93 MFGE8 EFNA1 RFLNB EXOC3L1

1.25e-05192178731a9142d97b690992aabee1a181650deb1a44253
ToppCellLPS-IL1RA-Endothelial-Endothelial-Vein|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF F2R MMRN1 CD93 TMTC1 RIN2 EXOC3L1

1.25e-051921787717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF SRARP GGT5 MMRN1 IGFBP1 EXOC3L1 CCN2

1.29e-0519317873f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNA PDE3A SLC25A34 DNAJB4 TENM3 INSC CCN2

1.29e-051931787323d1f3f4fbeb93ba857fc135d8aa0b897f98ac5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LONRF1 EDNRB GGT5 HHIP TMTC1 TENM3 CCN2

1.29e-051931787c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CNTNAP3B VWF SRARP MMRN1 CD93 EFNA1 MKI67

1.29e-051931787643f992dbce639e7d147924d8b8f455fcebf215a
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

CNTNAP3B VWF CXCL2 MMRN1 SHROOM4 TMTC1 RIN2

1.29e-0519317872531266bc57339d4e2b22a88817008e32b8c1598
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF F2R LRP1B GGT5 MMRN1 CD93 TMTC1

1.29e-0519317877261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWF EDNRB SHROOM4 KLHL5 TMTC1 RIN2 LTK

1.29e-051931787f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

CNTNAP3B VWF CXCL2 MMRN1 SHROOM4 TMTC1 RIN2

1.29e-05193178701c2df9206f1527c578e808978e58196c35e72f5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LONRF1 EDNRB GGT5 HHIP TMTC1 TENM3 CCN2

1.29e-0519317875b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell15-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

CNTNAP3B VWF LYPD2 MMRN1 CD93 EFNA1 EXOC3L1

1.33e-051941787ac0e48b0c09a7f57d30dff321b0c30a4c5e16ad9
ToppCell15-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

CNTNAP3B VWF LYPD2 MMRN1 CD93 EFNA1 EXOC3L1

1.33e-051941787f3851337a2d17f4acef2cd812a766eb0b503748b
ComputationalIGFBPs.

IGFBP1 CCN2 CCN3

9.63e-0512843MODULE_190
ComputationalAdhesion molecules.

VWF ITGAL ITGB5 ITGB7 MMRN1 MFGE8 CCN2

1.12e-04141847MODULE_122
ComputationalGenes in the cancer module 275.

ITGAL ITGB5 ITGB7

2.40e-0416843MODULE_275
ComputationalGenes in the cancer module 474.

IGFBP1 CCN2 CCN3

2.89e-0417843MODULE_474
Drug2-ketobenzothiazole 23

HSPD1 PPARA F2 F2R EDNRB LEFTY2 LEFTY1

3.70e-07601747CID003348131
DrugRgd Peptide

GP6 VWF ITGAD F2 F2R ITGB5 ITGB7 MFGE8 IGFBP1 FBN3 CCN3

2.42e-0623917411CID000104802
Drug17-AAG; Up 200; 1uM; HL60; HT_HG-U133A

HSPA4L ZC3H13 DUSP4 HSPH1 DNAJB4 CYP2W1 KLRG1 HSPA4 VPS13B

7.31e-0617217491159_UP
Drugnoradrealine

DRD4 GPR27 HSPA4L HSPH1 DGKQ PPARA EDNRB LEFTY2 MMP24 LEFTY1 IGFBP1 PER2 SLC18A3 FRZB FUT7 HSPA4

9.31e-0657517416CID000000951
DrugAC1O4QI2

ITGAD ITGAL CR2 F2R CD93 MED23 DDX41 VPS13B

1.07e-051371748CID006398444
Drugtroglitazone

GP6 HSPA4L HSPH1 SREBF1 PPARA CXCL2 LRP1B CAPN10 IGFBP1 TONSL LRP2 CCN2 IRS2 HSPA4 FBN3

1.34e-0552617415CID000005591
DiseaseMalignant neoplasm of breast

GPC1 FLNA VWF SRARP RPS8 ALS2CL CXCL2 EDNRB MFGE8 EFNA1 PER2 MKI67 EXOC3L1 LRRC7 SPOCD1 CTU1 MED12 VPS13B GABRA4

1.64e-05107417119C0006142
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

3.34e-0521712DOID:0110471 (implicated_via_orthology)
Diseasebrain edema (biomarker_via_orthology)

F2 F2R CXCL2

8.27e-05151713DOID:4724 (biomarker_via_orthology)
DiseaseAnorectal Malformations

EDNRB HHIP MED12 DKK4

9.33e-05411714C3495676
DiseaseFG syndrome (is_implicated_in)

FLNA MED12

9.98e-0531712DOID:14711 (is_implicated_in)
DiseaseFG SYNDROME 4 (disorder)

FLNA MED12

9.98e-0531712C1845546
DiseaseFG SYNDROME 2

FLNA MED12

9.98e-0531712C1845902
DiseaseFG SYNDROME 3

FLNA MED12

9.98e-0531712C1845567
DiseaseFG syndrome

FLNA MED12

9.98e-0531712C0220769
DiseaseFG syndrome

FLNA MED12

1.99e-0441712cv:C0220769
DiseaseMalignant Cystosarcoma Phyllodes

FLNA MED12

3.30e-0451712C0600066
DiseasePhyllodes Tumor

FLNA MED12

3.30e-0451712C0010701
Diseasehydrocephalus (biomarker_via_orthology)

HSPD1 PPARA

4.93e-0461712DOID:10908 (biomarker_via_orthology)
DiseaseParkinson's disease (biomarker_via_orthology)

HSPD1 CCN2 HSPA4

6.92e-04301713DOID:14330 (biomarker_via_orthology)
DiseaseAlcoholic Intoxication

DRD4 PER2 HSPA4

8.38e-04321713C0001969
Diseaselysophosphatidylethanolamine 18:1 measurement

LRP1B TMTC1 RIN2

1.00e-03341713EFO_0010368
Diseaseplasma renin activity measurement

TXNDC11 TENM3

1.17e-0391712EFO_0006828
Diseaseoptic disc size measurement

PRSS56 LRCH1 LRP1B LRP2 HS3ST6 ADAMTS14

1.29e-032051716EFO_0004832
DiseaseFatty Liver

SREBF1 PPARA F2 F2R

1.74e-03881714C0015695
DiseaseSteatohepatitis

SREBF1 PPARA F2 F2R

1.74e-03881714C2711227
DiseaseHerpes Zoster, response to tofacitinib

VWF ACSF3

2.12e-03121712EFO_0006510, EFO_0600024
DiseaseThrombus

PDE3A VWF F2

2.42e-03461713C0087086
DiseaseThrombosis

PDE3A VWF F2

2.90e-03491713C0040053
DiseaseMetabolic Bone Disorder

CTC1 LRP2

2.90e-03141712C0005944
Diseasebacterial pneumonia (biomarker_via_orthology)

F2 CXCL2

2.90e-03141712DOID:874 (biomarker_via_orthology)
Diseasepulmonary fibrosis (biomarker_via_orthology)

HSPD1 VWF CCN2

3.07e-03501713DOID:3770 (biomarker_via_orthology)
DiseaseLiver Cirrhosis

F2 F2R IGFBP1 CCN2

3.08e-031031714C0023890
Diseasereticulocyte count

GP6 SPIRE2 VWF PIEZO1 ITGAD F2R PTPRN IFRD2 IRS2 HERC1 RNF39 SPOCD1 HSPA4 MED12

3.18e-03104517114EFO_0007986
DiseaseFibrosis, Liver

F2 F2R IGFBP1 CCN2

3.30e-031051714C0239946
DiseaseNephrosis

F2 EDNRB

3.34e-03151712C0027720
DiseaseProteinuria

VWF LRP2

3.34e-03151712HP_0000093
DiseaseOsteopenia

CTC1 LRP2

3.34e-03151712C0029453
DiseaseStreptozotocin Diabetes

SREBF1 PPARA MFGE8 IRS2

3.66e-031081714C0038433
DiseaseDiabetes Mellitus, Experimental

SREBF1 PPARA MFGE8 IRS2

3.66e-031081714C0011853
DiseaseAlloxan Diabetes

SREBF1 PPARA MFGE8 IRS2

3.66e-031081714C0002152
DiseaseMammary Carcinoma, Human

FLNA RPS8 CXCL2 EDNRB MFGE8 EFNA1 MKI67 CTU1 MED12

3.67e-035251719C4704874
DiseaseMammary Neoplasms, Human

FLNA RPS8 CXCL2 EDNRB MFGE8 EFNA1 MKI67 CTU1 MED12

3.67e-035251719C1257931
DiseaseMammary Neoplasms

FLNA RPS8 CXCL2 EDNRB MFGE8 EFNA1 MKI67 CTU1 MED12

3.76e-035271719C1458155
DiseaseSpondyloepiphyseal Dysplasia

FLNA DLL3

3.80e-03161712C0038015
DiseaseSpondyloepiphyseal Dysplasia Tarda, X-Linked

FLNA DLL3

3.80e-03161712C3541456
DiseaseSchwartz-Jampel Syndrome, Type 1

FLNA DLL3

3.80e-03161712C4551479
DiseaseSchwartz-Jampel Syndrome

FLNA DLL3

3.80e-03161712C0036391
DiseaseMelnick-Needles Syndrome

FLNA DLL3

3.80e-03161712C0025237
DiseaseAcute Cerebrovascular Accidents

PDE3A F2 LRCH1

3.82e-03541713C0751956
DiseaseCongestive heart failure

VWF CXCL2 EDNRB CCN2

3.90e-031101714C0018802
DiseaseHeart failure

VWF CXCL2 EDNRB CCN2

3.90e-031101714C0018801
DiseaseLeft-Sided Heart Failure

VWF CXCL2 EDNRB CCN2

3.90e-031101714C0023212
DiseaseHeart Failure, Right-Sided

VWF CXCL2 EDNRB CCN2

3.90e-031101714C0235527
DiseaseHeart Decompensation

VWF CXCL2 EDNRB CCN2

3.90e-031101714C1961112
DiseaseMyocardial Failure

VWF CXCL2 EDNRB CCN2

3.90e-031101714C1959583
Diseasediabetic neuropathy (biomarker_via_orthology)

SREBF1 HHIP

4.29e-03171712DOID:9743 (biomarker_via_orthology)
DiseaseVan Buchem disease

FLNA DLL3

4.29e-03171712C0432272
Diseasealpha-L-iduronidase measurement

DGKQ TMEM271

4.29e-03171712EFO_0020139
DiseaseBreast Carcinoma

FLNA RPS8 CXCL2 EDNRB MFGE8 EFNA1 MKI67 CTU1 MED12

4.30e-035381719C0678222
DiseaseChild Behaviour Checklist assessment

LEFTY1 TENM3

4.81e-03181712EFO_0005661
Diseasealcoholic hepatitis (biomarker_via_orthology)

SREBF1 PPARA

4.81e-03181712DOID:12351 (biomarker_via_orthology)
DiseaseInsulin Resistance

SREBF1 PPARA IRS2

5.14e-03601713C0021655
DiseaseSjogren syndrome

KCP DGKQ KLRG1

5.14e-03601713EFO_0000699
DiseaseInsulin Sensitivity

SREBF1 PPARA IRS2

5.14e-03601713C0920563
DiseaseOsteochondrodysplasias

FLNA DLL3

5.35e-03191712C0029422
Diseasecarotid artery disease (is_marker_for)

HSPD1 VWF

5.35e-03191712DOID:3407 (is_marker_for)
DiseaseDyschondroplasias

FLNA DLL3

5.35e-03191712C0013366
DiseaseCerebrovascular accident

PDE3A F2 LRCH1

5.63e-03621713C0038454
Diseasecystic fibrosis (is_marker_for)

HSPD1 PPARA CXCL2

5.63e-03621713DOID:1485 (is_marker_for)
DiseaseLiver Cirrhosis, Experimental

FLNA VWF SREBF1 ITGAL F2R COQ10A IGFBP1 MKI67 CCN2 RNF39 CRTAP

5.65e-0377417111C0023893

Protein segments in the cluster

PeptideGeneStartEntry
CAGCPRDLQEALLGF

ALS2CL

611

Q60I27
SCLPSGSCARALLLA

EXOC3L1

731

Q86VI1
GCCALTREGLPARLQ

ARL5C

156

A6NH57
SCISRRPLELAGCAS

CTC1

836

Q2NKJ3
RPLELAGCASCLTVQ

CTC1

841

Q2NKJ3
GGCELASVLQLNPCR

RBBP8

621

Q99708
DACCLLNCTLRPGAA

ADAM21

431

Q9UKJ8
LNCTLRPGAACAFGL

ADAM21

436

Q9UKJ8
GCRPGFRLLDDLVTC

CD93

286

Q9NPY3
AACVGASRICLQLSP

CCNJL

256

Q8IV13
GLLCACAQDPSPAAR

CYP2W1

16

Q8TAV3
CSAALAPECGFGRLR

DGKQ

226

P52824
SLCGRALVALVLACG

EDNRB

6

P24530
RLGCALASCRLAPAR

ACSF3

11

Q4G176
DRLPCLAGRLCFSRC

CAPN10

126

Q9HC96
SCCVLSPRAGARELG

CAPN10

221

Q9HC96
LAGCPRISERGLACL

DMAC2

181

Q9NW81
GCALLRCIPALDSLT

HSPD1

441

P10809
RCSLQPCRNGGLCLD

DLL3

356

Q9NYJ7
LSSPCVSGVCRNLAG

FBN3

771

Q75N90
ECAEALGAIARPACL

DOHH

241

Q9BU89
ALFISPALIRCCTRG

ATP5MC1

6

P05496
LLPLHCALCAAAGSR

ADAMTS14

11

Q8WXS8
LGRLGPRALCTQLAC

C17orf113

571

A0A1B0GUU1
AAACPRGLQLQCRGA

NOXA1

381

Q86UR1
GSSDPLRCCLAVGAR

TSPOAP1

866

O95153
LRCCLAVGARAGVVP

TSPOAP1

871

O95153
CSRGRALEPGLASCL

TSPOAP1

1476

O95153
GALCRACLALAAALA

RFNG

6

Q9Y644
RADCLTQCAARRLGP

P3H3

121

Q8IVL6
NCLRCLNPALGNLTA

LRCH4

101

O75427
VASCPDARLLAGCEG

LRWD1

451

Q9UFC0
LLCLDGQQSPRATLC

NXF3

306

Q9H4D5
PALCCLPGAARAAAA

MMP24

41

Q9Y5R2
AGSAAAPRGRCLLLA

OTUD1

136

Q5VV17
CLLLLSSRPGGCSAV

PTPRN

21

Q16849
LCQKGLARGLSPARC

KLHL33

61

A6NCF5
CSCASDGALVPRRLQ

LEFTY1

351

O75610
STLCLAIPGGRVCAC

LRP1B

806

Q9NZR2
LLLRRPHGCSSCDEG

TRIM71

191

Q2Q1W2
AVTRGCALQCAILSP

HSPA4

371

P34932
CGALLCAPSLLVALD

MFGE8

11

Q08431
GITLQPARLSGDCCT

LRRC7

491

Q96NW7
CCSALGRVLLFSPTL

NLRP11

791

P59045
LCAAAALVACARGDP

GPC1

11

P35052
NLTCCIDRSLPGSLA

MMRN1

981

Q13201
LRCLGCRGFLSEPVT

LONRF1

121

Q17RB8
LALGRLPCSDNCTAL

FRMD7

106

Q6ZUT3
KGPLELANALAACCL

HERC1

3361

Q15751
AVARGCALQCAILSP

HSPH1

371

Q92598
LCSREGACSCLPLER

LMTK3

671

Q96Q04
GACSCLPLERGDAVA

LMTK3

676

Q96Q04
ARNCLLSCAGPSRVA

LTK

646

P29376
TALFCLGLCLGRVPA

GP6

6

Q9HCN6
CLADGLRALACLPAV

GPR27

61

Q9NS67
LDCLAGPALACGLSQ

PER2

701

O15055
ALEAAAPCRACVGSI

PLXNB3

626

Q9ULL4
PLGAACGVATARCAR

IGFBP1

66

P08833
ARCARGLSCRALPGE

IGFBP1

76

P08833
RLPLAVALLAACCGG

PDE3A

156

Q14432
VFGRANGRPLCASCL

FUT7

201

Q11130
ARINSICGRCSLLPV

MED23

216

Q9ULK4
ACPAASCLGLGRLLG

MEGF8

596

Q7Z7M0
CLCSLRGGALQRAND

KDM4A

776

O75164
SRNQLSALPACLCGL

LRCH1

151

Q9Y2L9
TLRVDGNPLACDCRL

LINGO3

346

P0C6S8
LIRCAAIPSLLNAAC

MED12

1146

Q93074
LRFLCLAVCLNESPG

GABRA4

21

P48169
PACAAAALGLCSLLL

LRRC38

6

Q5VT99
GSDELALCPQRFCRL

LRP2

3541

P98164
CQGRARLLLTGLHAC

METTL25B

246

Q96FB5
PLSLSTCLFGRGIEC

MKI67

21

P46013
LRDCVSNGSLGCPVR

PGAP6

226

Q9HCN3
AALRCAQALRCQPLG

LINC00336

26

Q6ZUF6
ALGTCRLAGTALCVA

NRSN2

111

Q9GZP1
EDSSPLLRCALCIGG

DDX41

286

Q9UJV9
TQVAPLCLGRAGACV

KLHL5

736

Q96PQ7
CALLPRLAGLNICTS

ITGB5

16

P18084
LCGLNDVRGRDPAVC

DRD4

171

P21917
RNPALAGSAIRCLLC

PEG3

1216

Q9GZU2
LVLAACGELAPALRC

LYPD2

11

Q6UXB3
SCAPGRLGRLCECSV

ITGB7

501

P26010
ACFSLCGPLLSARTR

F2R

11

P25116
SRLLACGPTLHRVCG

ITGAD

101

Q13349
ANACGLLRNSACPLV

MRGPRG

141

Q86SM5
AGAPKRVIALDCCLN

IRS2

86

Q9Y4H2
LDCRLAGPCETRATL

FRMD1

511

Q8N878
ALCGCSINVPTLDGR

DNAJB4

261

Q9UDY4
SRPSCSCLVAIALGL

KLRG1

31

Q96E93
RAAGAPLATELRCQC

CXCL2

31

P19875
VLAALLACASSCGVP

CTRC

6

Q99895
AVCRSRSLAPVLCGI

CR2

966

P20023
CRCFAGDTLLAIRAP

E2F4

146

Q16254
APGVRAVLDGCSCCL

CCN3

51

P48745
CGPGLLCRSQLTSNR

DKK4

196

Q9UBT3
APLLGLCCSLAAADR

EFNA1

6

P20827
RALGALVDSCAPGLC

FLNA

196

P21333
LLALCSRPAVGQNCS

CCN2

16

P29279
RGAAALLALLCVACA

CRTAP

6

O75718
LRRPLSGQALCGACF

CTU1

16

Q7Z7A3
GALASRALCQACALL

CTU1

291

Q7Z7A3
AAERCCRLSLSPGAQ

COQ10A

16

Q96MF6
NELLDLCERCPRGSG

GGT5

426

P36269
CLALCSLLTGTRADP

BPIFB6

6

Q8NFQ5
CSCASDGALVPRRLQ

LEFTY2

351

O00292
PAARLHCASALGLGC

IFRD2

241

Q12894
RKPACGLCQLARSCS

DAGLA

311

Q9Y4D2
CLAALRRLAGVCPEG

INSC

536

Q1MX18
GRLASCGSLLCRPTC

KRTAP10-12

226

P60413
TLLCAALAGCLLPAE

IZUMO1

6

Q8IYV9
LEDTPRQCRICGGLA

CYLD

781

Q9NQC7
VGGLICRACNLSLPF

C9orf57

76

Q5W0N0
SGGKCLLLDCRPFLA

DUSP4

41

Q13115
SVSADCCIPAGLRLG

PRDM13

11

Q9H4Q3
LLACIASRPGQCGRA

RPS8

171

P62241
ALCGSARLLNCTAPG

SLC15A4

131

Q8N697
RCCSPATFAGLVLVG

SLC15A4

151

Q8N697
VVARCSEGPGLCLAR

NIT1

281

Q86X76
GCLSAVRFGCAAPLK

CNTNAP3B

1166

Q96NU0
GRVGCADSRLLSPAC

PPP6R2

866

O75170
ALVLGAYCLCALPGR

HS3ST6

36

Q96QI5
RLCPGSQGACARLAH

PRSS56

371

P0CW18
ALLRASGLPVQPCCA

PARP10

111

Q53GL7
SLFVAAIICCGDRPG

PPARA

376

Q07869
HRAAGPCLLAECRNL

MACROD2

106

A1Z1Q3
LGLIFDRGDPCQACS

SYTL5

71

Q8TDW5
ACRSFAPLVVSLCGL

SLC18A3

376

Q16572
GCLAQARATLPLCRG

SRARP

101

Q8NEQ6
AALQLLCRADAGPLC

RNF187

91

Q5TA31
AASCRLQGAPGLCVA

TMEM132B

171

Q14DG7
PAVDLVLGASACCLA

SLC25A34

6

Q6PIV7
CALRLCPLSFGEGVE

RFLNB

81

Q8N5W9
ALPASGRQLCPACEL

KCP

416

Q6ZWJ8
RQEGACCLGLLCASL

SMG1

211

Q96Q15
GLGLSPDLVVCRCSN

CTPS1

206

P17812
LLASLPAGSLRCITC

ST6GALNAC1

351

Q9NSC7
VLPARNPNRFCCLSG

SHROOM4

316

Q9ULL8
RPAACGRTSLTNLLC

PRDX3

31

P30048
GNAVACLRLFPCSAV

SLC25A43

71

Q8WUT9
GSILACDPGLSRTCD

ITGAL

106

P20701
LSCCLRSDSPGLGRL

HHIP

76

Q96QV1
VGACSCLAPELSRLS

STRC

1076

Q7RTU9
GGDPRCCELLLFNRA

SHANK1

291

Q9Y566
LCLSCNPLASLLGAR

SREBF1

496

P36956
PCLGLLANLCRHNLS

CIP2A

161

Q8TCG1
AFACRGCQLAPERGA

COA8

31

Q96IL0
ARALGCCSLPAESLD

PNMA5

121

Q96PV4
SSDGVCPASLRQLCL

RIN2

231

Q8WYP3
SADLLRLPCGICGKA

ZNF865

401

P0CJ78
PAGAAALLAGASCLC

TMTC1

26

Q8IUR5
APDLVLQRCCSGEGL

VWF

1661

P04275
CGRCLPTACTIQLRG

VWF

2641

P04275
PALGCLAACGRTIQR

SLC16A5

211

O15375
LVFLCSGCRRPLGDS

MIS18A

81

Q9NYP9
ALCLLRVPGARAAAC

FRZB

21

Q92765
PAGTRACLLVQDACG

SPIDR

511

Q14159
AVARGCALQCAILSP

HSPA4L

371

O95757
SDVESLPRGGFRCCL

TUT1

6

Q9H6E5
ARGFGSLPCILNACS

SPIRE2

366

Q8WWL2
CPLLSTLRLQACGFG

TONSL

1156

Q96HA7
CSRSAGLPERALACR

SPOCD1

136

Q6ZMY3
RPENAGACCLGLLDE

TMEM102

426

Q8N9M5
VVSLRCSECGARPLA

TMPRSS5

201

Q9H3S3
CSECGARPLASRIVG

TMPRSS5

206

Q9H3S3
LGVCEPATRRGLAFC

TENM3

86

Q9P273
GCGDCRLASSIRNPV

RRP8

316

O43159
KGALVPSALEGRLCC

NSD3

1391

Q9BZ95
ICSALLLLAAAGCLP

TMEM241

126

Q24JQ0
QRPELLCGAVALGCA

TXNDC11

61

Q6PKC3
RACANGPCLSVRARL

VWA5B2

21

Q8N398
SRILIGPCCATANLE

VPS13B

2201

Q7Z7G8
LADNPLRCGCAARPL

TPBGL

231

P0DKB5
GLQLPGCLALAALCS

F2

6

P00734
CLGAACSLAGEFRTP

SLC35E4

171

Q6ICL7
VGACSCLAPELSRLS

STRCP1

1076

A6NGW2
TARPCQLLDLGCSLA

TESPA1

121

A2RU30
PLLGSACRLAENCVC

PLIN5

51

Q00G26
PCALLAACLLRFSGL

PIEZO1

16

Q92508
SLGALGPACCRVLSE

TARBP2

286

Q15633
AVELPLCGRRTALCA

TMEM70

11

Q9BUB7
SNSLLNCIRACGPRA

SLC27A6

141

Q9Y2P4
LCNQAGALAEPCRGL

SLIT1

1411

O75093
GLSLLGAALLCCGPR

TMEM271

61

A0A286YF58
QCASLGCLLRNLIDG

USP6

261

P35125
CGSCCPGGLRRSLLL

ZNF282

496

Q9UDV7
RASLLSNLGPCCKAL

ZC3H13

1581

Q5T200
RLEQLATCPLCGGSF

RNF39

81

Q9H2S5
SRILLCEPFSCRAGE

ZAN

2681

Q9Y493
LGPGRKCCALANLAD

GEMIN4

231

P57678