Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PLAC	ADAMTS16 ADAMTS18	2.89e-04	14	34	2	PF08686
Domain	PLAC	ADAMTS16 ADAMTS18	5.39e-04	19	34	2	IPR010909
Domain	PLAC	ADAMTS16 ADAMTS18	5.39e-04	19	34	2	PS50900
Domain	ADAM_spacer1	ADAMTS16 ADAMTS18	7.95e-04	23	34	2	IPR010294
Domain	ADAM_spacer1	ADAMTS16 ADAMTS18	7.95e-04	23	34	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS16 ADAMTS18	8.66e-04	24	34	2	IPR013273
Domain	Peptidase_M12B_N	ADAMTS16 ADAMTS18	2.29e-03	39	34	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS16 ADAMTS18	2.29e-03	39	34	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS16 ADAMTS18	2.40e-03	40	34	2	PS00427
Domain	ADAM_MEPRO	ADAMTS16 ADAMTS18	2.40e-03	40	34	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS16 ADAMTS18	2.40e-03	40	34	2	PS50214
Domain	Reprolysin	ADAMTS16 ADAMTS18	2.40e-03	40	34	2	PF01421
Domain	Peptidase_M12B	ADAMTS16 ADAMTS18	2.40e-03	40	34	2	IPR001590
Domain	zf-C2H2_6	ZNF69 ZNF555 ZNF564 ZNF440	2.44e-03	314	34	4	PF13912
Domain	CYSTEINE_SWITCH	ADAMTS16 ADAMTS18	2.52e-03	41	34	2	PS00546
Domain	Disintegrin_dom	ADAMTS16 ADAMTS18	2.52e-03	41	34	2	IPR001762
Domain	Pept_M10_metallopeptidase	ADAMTS16 ADAMTS18	2.77e-03	43	34	2	IPR001818
Domain	KRAB	ZNF69 ZNF555 ZNF564 ZNF440	3.91e-03	358	34	4	PS50805
Domain	KRAB	ZNF69 ZNF555 ZNF564 ZNF440	3.91e-03	358	34	4	PF01352
Domain	KRAB	ZNF69 ZNF555 ZNF564 ZNF440	4.35e-03	369	34	4	SM00349
Domain	KRAB	ZNF69 ZNF555 ZNF564 ZNF440	4.40e-03	370	34	4	IPR001909
Domain	TSP_1	ADAMTS16 ADAMTS18	5.86e-03	63	34	2	PF00090
Domain	TSP1	ADAMTS16 ADAMTS18	6.23e-03	65	34	2	SM00209
Domain	TSP1_rpt	ADAMTS16 ADAMTS18	6.23e-03	65	34	2	IPR000884
Domain	TSP1	ADAMTS16 ADAMTS18	6.23e-03	65	34	2	PS50092
Domain	USP_CS	USP5 USP9X	6.41e-03	66	34	2	IPR018200
Domain	USP_1	USP5 USP9X	7.19e-03	70	34	2	PS00972
Domain	UCH	USP5 USP9X	7.39e-03	71	34	2	PF00443
Domain	USP_2	USP5 USP9X	7.39e-03	71	34	2	PS00973
Domain	USP_3	USP5 USP9X	7.59e-03	72	34	2	PS50235
Domain	USP_dom	USP5 USP9X	7.59e-03	72	34	2	IPR028889
Domain	Peptidase_C19_UCH	USP5 USP9X	7.59e-03	72	34	2	IPR001394
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PHKA1 PYGL	2.71e-04	14	25	2	MM15391
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PHKA1 PYGL	2.71e-04	14	25	2	M19193
Pathway	REACTOME_GLYCOGEN_METABOLISM	PHKA1 PYGL	4.54e-04	18	25	2	MM15577
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	GK2 PLPP1	7.47e-04	23	25	2	MM15890
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	GK2 PLPP1	8.14e-04	24	25	2	M39692
Pathway	REACTOME_GLYCOGEN_METABOLISM	PHKA1 PYGL	8.83e-04	25	25	2	M27857
Pathway	REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES	USP5 USP9X	1.27e-03	30	25	2	M27762
Pathway	REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES	USP5 USP9X	1.27e-03	30	25	2	MM15507
Pathway	WP_GLYCOGEN_METABOLISM	PHKA1 PYGL	1.64e-03	34	25	2	MM15985
Pathway	REACTOME_INTRA_GOLGI_TRAFFIC	COG7 RIC1	1.94e-03	37	25	2	MM15354
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS16 ADAMTS18	2.15e-03	39	25	2	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS16 ADAMTS18	2.15e-03	39	25	2	MM15165
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	PHKA1 PYGL	2.26e-03	40	25	2	M39595
Pathway	REACTOME_INTRA_GOLGI_TRAFFIC	COG7 RIC1	2.73e-03	44	25	2	M27652
Pathway	REACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK	COG7 RIC1	2.85e-03	45	25	2	MM15355
Pathway	REACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK	COG7 RIC1	3.37e-03	49	25	2	M27653
Pathway	KEGG_GLYCEROLIPID_METABOLISM	GK2 PLPP1	3.37e-03	49	25	2	M15902
Pubmed	Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia.	ADAMTS16 ADAMTS18	9.84e-07	2	35	2	26382559
Pubmed	Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart.	CD46 CXADR	9.84e-07	2	35	2	19957088
Pubmed	USP11 degrades KLF4 via its deubiquitinase activity in liver diseases.	USP5 USP9X	5.90e-06	4	35	2	34114341
Pubmed	Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.	ADAMTS16 ADAMTS18	5.90e-06	4	35	2	16507336
Pubmed	USP5 enhances SGTA mediated protein quality control.	USP5 USP9X	5.90e-06	4	35	2	35895711
Pubmed	The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.	USP5 USP9X	9.82e-06	5	35	2	26235645
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS16 ADAMTS18	2.06e-05	7	35	2	11867212
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	PYGL USP5 USP9X	3.73e-05	64	35	3	33141564
Pubmed	USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.	PYGL USP9X	4.40e-05	10	35	2	36653359
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	CSTF3 USP5 THRAP3 EFTUD2	6.99e-05	220	35	4	35785414
Pubmed	Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.	ADAMTS16 ADAMTS18	8.89e-05	14	35	2	31242448
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CSTF3 PLPP1 CATSPERG SH3RF3 THRAP3 RIC1 ZNF440 NUCB2	9.27e-05	1489	35	8	28611215
Pubmed	The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.	ADAMTS16 ADAMTS18	1.02e-04	15	35	2	7543410
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP5 USP9X	1.02e-04	15	35	2	9827704
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	USP5 USP9X	1.17e-04	16	35	2	36484700
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS16 ADAMTS18	1.17e-04	16	35	2	30579834
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ADAMTS16 BAZ2B ATRNL1 RIC1 EFTUD2	1.28e-04	493	35	5	15368895
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP5 USP9X	1.33e-04	17	35	2	23287719
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TOP1 USP9X THRAP3 MIER3	2.00e-04	289	35	4	23752268
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	PHKA1 USP9X	2.24e-04	22	35	2	35120648
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	USP5 USP9X	2.24e-04	22	35	2	37225996
Pubmed	Large-scale concatenation cDNA sequencing.	ZNF555 SPRED2 COG7 USP9X WDPCP	2.47e-04	568	35	5	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	ZNF555 SPRED2 COG7 USP9X WDPCP	2.59e-04	574	35	5	8619474
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	USP5 PLPP1 USP9X THRAP3	2.70e-04	313	35	4	38270169
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	USP9X THRAP3 EFTUD2	3.49e-04	136	35	3	26979993
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	USP5 TOP1 USP9X THRAP3 EFTUD2	3.56e-04	615	35	5	31048545
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	CSTF3 TOP1 USP9X	3.65e-04	138	35	3	37506885
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	CSTF3 BAZ2B TOP1 THRAP3	3.70e-04	340	35	4	29478914
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CSTF3 USP5 COG7 USP9X EFTUD2	4.21e-04	638	35	5	33239621
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	USP5 TOP1 USP9X	4.21e-04	145	35	3	28846114
Pubmed	Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function.	USP5 USP9X	4.49e-04	31	35	2	36114200
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	TOP1 EFTUD2	4.79e-04	32	35	2	15848144
Pubmed	Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.	BAZ2B SH3RF3	4.79e-04	32	35	2	24706805
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CSTF3 TOP1 USP9X THRAP3 CXADR EFTUD2	5.02e-04	1024	35	6	24711643
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	ADAMTS16 ADAMTS18	6.41e-04	37	35	2	34323105
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CSTF3 TOP1 USP9X THRAP3 EFTUD2	6.96e-04	713	35	5	29802200
Pubmed	Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.	USP9X THRAP3	7.12e-04	39	35	2	25944111
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	BAZ2B TOP1 THRAP3 EFTUD2	7.53e-04	411	35	4	35182466
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	PYGL USP9X THRAP3	7.77e-04	179	35	3	36261009
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF555 ZNF564 ZNF440	8.03e-04	181	35	3	37372979
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PHKA1 TOP1 USP9X THRAP3	9.06e-04	432	35	4	23455922
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	PHKA1 PYGL USP5 TOP1 USP9X EFTUD2	9.16e-04	1149	35	6	35446349
Cytoband	9p22.1	SLC24A2 DENND4C	5.11e-05	14	35	2	9p22.1
Cytoband	19p13.2	ZNF69 ZNF564 ZNF440	7.13e-04	229	35	3	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9p22	SLC24A2 DENND4C	7.59e-04	53	35	2	chr9p22
Cytoband	Ensembl 112 genes in cytogenetic band chr5q11	PLPP1 MIER3	2.41e-03	95	35	2	chr5q11
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF69 ZNF555 ZNF564 ZNF440	3.08e-03	797	35	4	chr19p13
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS16 ADAMTS18	3.35e-04	19	26	2	50
GeneFamily	Ubiquitin specific peptidases	USP5 USP9X	2.92e-03	56	26	2	366
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF69 ZNF555 ZNF564 ZNF440	1.84e-02	718	26	4	28
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_MDC_UP	CSTF3 USP5 SLC24A2 COG7 ATRNL1	6.47e-06	199	35	5	M5009
Disease	glycogen storage disease (is_implicated_in)	PHKA1 PYGL	4.62e-05	9	34	2	DOID:2747 (is_implicated_in)
Disease	blood aluminium measurement	GK2 BAZ2B	2.42e-04	20	34	2	EFO_0007575
Disease	vesicoureteral reflux	CATSPERG WDPCP	8.83e-04	38	34	2	EFO_0007536
Disease	reading and spelling ability	GK2 SLC24A2 SH3RF3	9.20e-04	166	34	3	EFO_0005301
Disease	Premature atrial contractions	ZNF69 ZNF440	1.84e-03	55	34	2	HP_0006699
Disease	basophil measurement	CPA4 WDPCP	2.19e-03	60	34	2	EFO_0803539
Disease	non-word reading	ADAMTS16 SLC24A2	2.72e-03	67	34	2	EFO_0005299
Disease	aortic measurement	ADAMTS18 CD46 CXADR	3.00e-03	251	34	3	EFO_0020865
Disease	carotid plaque build	GFY ATRNL1	4.23e-03	84	34	2	EFO_0006501
Disease	fasting blood glucose measurement	SLC24A2 TOP1 MIER3	4.36e-03	287	34	3	EFO_0004465
Disease	serum iron measurement	GK2 SLC24A2	4.43e-03	86	34	2	EFO_0006332
Disease	S-warfarin to R-warfarin ratio measurement	SLC24A2 ATRNL1	5.38e-03	95	34	2	EFO_0803331

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDPSEKYLGFPYYLK	CATSPERG	86	Q6ZRH7
KYAPRLPADYYNEKL	CFAP54	116	Q96N23
VYDPYKPYQLKYGDM	COG7	351	P83436
AYYAPCGKKLRQYPE	BAZ2B	771	Q9UIF8
YKYPEKLPGELYDAN	ADAMTS16	501	Q8TE57
AGQYKYPDKLPGQIY	ADAMTS18	501	Q8TE60
DKYLYEPVYPKGSPQ	RIC1	101	Q4ADV7
DYKCKKGYFYIPPLA	CD46	61	P15529
YKLGRDKPVYYALEG	GK3P	306	Q14409
YKTPKEDPNRLYYEP	PHKA1	301	P46020
GLKKYGDIPEYVLAY	CSTF3	436	Q12996
IPPYLGEYDGNEKVY	MIER3	186	Q7Z3K6
EPPDTGLYYDEYLKQ	NUCB2	46	P80303
DIGIYQYYDKKDPPA	WDPCP	56	O95876
YKLGREKPAYYALEG	GK2	306	Q14410
LDAPKDPYDLYFYAP	GFY	456	I3L273
GDKIYDDYYPDLKGR	CXADR	76	P78310
YPYGYSVKKAPDAEE	CPA4	316	Q9UI42
PDDGKDLSPKYSYKY	DENND4C	696	Q5VZ89
PGNKYGLVDDLYKYE	ATRNL1	491	Q5VV63
FAYLKDKLPYPYDDP	GPX2	116	P18283
PPIKYQYAELGKLYS	USP9X	2216	Q93008
PLAEELGSYGKLKYY	SLC24A2	356	Q9UI40
KYPYKEDTIPYALLG	PLPP1	46	O14494
LGHKPYDYQEYGEKP	ZNF564	126	Q8TBZ8
HKAYEYQEYGPKPCK	ZNF440	131	Q8IYI8
PEYTPKSKKYYLHDD	THRAP3	871	Q9Y2W1
NLYKKIPPGVKQYEY	ZNF555	131	Q8NEP9
LPYGKALYSYEGKEP	SH3RF3	196	Q8TEJ3
KGEVPKHDYNYPYVD	SPRED2	256	Q7Z698
AAQKLKEYLGFEYPP	REP15	31	Q6BDI9
HKAYEYQEYGPKPCK	ZNF69	151	Q9UC07
EDKKYYPTAEEVYGP	EFTUD2	61	Q15029
GYEAKEYYEALPELK	PYGL	726	P06737
YEPLPENVKFYYDGK	TOP1	231	P11387
EKPPKDLGYIYFYQR	USP5	841	P45974