Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

2.36e-119595GO:0036374
GeneOntologyMolecularFunctionomega peptidase activity

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

8.07e-1016595GO:0008242
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-096594GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-096594GO:0002951
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

2.84e-0920595GO:0070003
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGTLC1 GGTLC2 GGT2P GGT1

4.77e-098594GO:0103068
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

YTHDF1 KMT2D MRTFB TIAL1 MED29 PPRC1 NUP98 MED14 SUPT20HL2 ZC3H18 MIDEAS CREBBP STRIP1

2.66e-0511605913GO:0030674
GeneOntologyMolecularFunctiontranscription coregulator activity

KMT2D MRTFB MED29 PPRC1 NUP98 MED14 SUPT20HL2 MIDEAS CREBBP

3.73e-05562599GO:0003712
GeneOntologyMolecularFunctiontranscription factor binding

LATS1 SATB1 MED29 PPRC1 PCLO MED25 MED14 TAF4 FOXA2 CREBBP

6.45e-057535910GO:0008134
GeneOntologyMolecularFunctionmolecular adaptor activity

YTHDF1 KMT2D MRTFB TIAL1 MED29 PPRC1 NUP98 MED14 SUPT20HL2 ZC3H18 MIDEAS CREBBP STRIP1

1.32e-0413565913GO:0060090
GeneOntologyMolecularFunctiontranscription coactivator activity

KMT2D MRTFB PPRC1 NUP98 MED14 CREBBP

2.66e-04303596GO:0003713
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

GGTLC1 GGTLC2 GGT2P GGT1

8.68e-04144594GO:0140101
GeneOntologyMolecularFunctioncGMP binding

CNGB3 RAPGEF2

1.00e-0316592GO:0030553
GeneOntologyMolecularFunctionchromatin binding

SFPQ SATB1 EP400 NUP98 FOXA2 CREBBP HELLS FOXC2

1.42e-03739598GO:0003682
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2D SETBP1

1.58e-0320592GO:0042800
GeneOntologyMolecularFunctionadrenergic receptor binding

GNAS RAPGEF2

2.27e-0324592GO:0031690
GeneOntologyMolecularFunctionprotein-RNA adaptor activity

YTHDF1 TIAL1

2.27e-0324592GO:0140517
GeneOntologyMolecularFunctionpeptidase activity

GGTLC3 ADAM9 GGTLC1 NUP98 GGTLC2 GGT2P GGT1

3.05e-03654597GO:0008233
GeneOntologyBiologicalProcessleukotriene D4 biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.67e-1110585GO:1901750
GeneOntologyBiologicalProcessglutathione catabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

6.72e-1111585GO:0006751
GeneOntologyBiologicalProcessleukotriene D4 metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.15e-1012585GO:1901748
GeneOntologyBiologicalProcessleukotriene biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.74e-0922585GO:0019370
GeneOntologyBiologicalProcesscysteine biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

3.91e-098584GO:0019344
GeneOntologyBiologicalProcesspeptide modification

GGTLC1 GGTLC2 GGT2P GGT1

1.17e-0810584GO:0031179
GeneOntologyBiologicalProcessmodified amino acid catabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

6.00e-0837585GO:0042219
GeneOntologyBiologicalProcesscysteine metabolic process

GGTLC1 GGTLC2 GGT2P GGT1

9.99e-0816584GO:0006534
GeneOntologyBiologicalProcessleukotriene metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.02e-0741585GO:0006691
GeneOntologyBiologicalProcessglutathione biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

2.64e-0720584GO:0006750
GeneOntologyBiologicalProcesssulfur amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

3.25e-0721584GO:0000097
GeneOntologyBiologicalProcessfatty acid derivative biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.46e-0752585GO:1901570
GeneOntologyBiologicalProcesssulfur compound catabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.82e-0753585GO:0044273
GeneOntologyBiologicalProcessnonribosomal peptide biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

3.96e-0722584GO:0019184
GeneOntologyBiologicalProcessprotein-DNA complex organization

SFPQ KMT2D SATB1 EP400 MED29 BICRA SETBP1 MED25 MED14 TAF4 GNAS FOXA2 CREBBP HELLS

4.92e-079995814GO:0071824
GeneOntologyBiologicalProcessserine family amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

6.81e-0725584GO:0009070
GeneOntologyBiologicalProcessglutathione metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

9.15e-0763585GO:0006749
GeneOntologyBiologicalProcessicosanoid biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.25e-0667585GO:0046456
GeneOntologyBiologicalProcesspeptide biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

2.45e-0634584GO:0043043
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.41e-0682585GO:1901568
GeneOntologyBiologicalProcesssulfur amino acid metabolic process

GGTLC1 GGTLC2 GGT2P GGT1

4.77e-0640584GO:0000096
GeneOntologyBiologicalProcessserine family amino acid metabolic process

GGTLC1 GGTLC2 GGT2P GGT1

6.40e-0643584GO:0009069
GeneOntologyBiologicalProcessmodified amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

1.38e-0552584GO:0042398
GeneOntologyBiologicalProcessproteinogenic amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

4.25e-0569584GO:0170038
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

MED29 MED25 MED14 TAF4

4.49e-0570584GO:0060261
GeneOntologyBiologicalProcessL-amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

4.49e-0570584GO:0170034
GeneOntologyBiologicalProcessRNA polymerase II preinitiation complex assembly

MED29 MED25 MED14 TAF4

4.75e-0571584GO:0051123
GeneOntologyBiologicalProcessicosanoid metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

4.92e-05142585GO:0006690
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

MED29 MED25 MED14 TAF4

6.54e-0577584GO:2000144
GeneOntologyBiologicalProcessalpha-amino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

6.54e-0577584GO:1901607
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

MED29 MED25 MED14 TAF4

7.97e-0581584GO:0060260
GeneOntologyBiologicalProcesspeptide metabolic process

GGTLC1 GGTLC2 GGT2P GGT1

9.18e-0584584GO:0006518
GeneOntologyBiologicalProcesstranscription preinitiation complex assembly

MED29 MED25 MED14 TAF4

9.62e-0585584GO:0070897
GeneOntologyBiologicalProcessamino acid biosynthetic process

GGTLC1 GGTLC2 GGT2P GGT1

1.01e-0486584GO:0008652
GeneOntologyBiologicalProcessamide biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.22e-04172585GO:0043604
GeneOntologyBiologicalProcessregulation of DNA-templated transcription initiation

MED29 MED25 MED14 TAF4

1.25e-0491584GO:2000142
GeneOntologyBiologicalProcesssulfur compound biosynthetic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.43e-04178585GO:0044272
GeneOntologyBiologicalProcessproteinogenic amino acid metabolic process

GGTLC1 SLC45A2 GGTLC2 GGT2P GGT1

1.71e-04185585GO:0170039
GeneOntologyBiologicalProcesschromatin organization

SFPQ KMT2D SATB1 EP400 BICRA SETBP1 GNAS FOXA2 CREBBP HELLS

1.78e-048965810GO:0006325
GeneOntologyBiologicalProcesschromatin remodeling

SFPQ KMT2D SATB1 EP400 BICRA SETBP1 GNAS CREBBP HELLS

2.09e-04741589GO:0006338
GeneOntologyBiologicalProcessL-amino acid metabolic process

GGTLC1 SLC45A2 GGTLC2 GGT2P GGT1

2.95e-04208585GO:0170033
GeneOntologyBiologicalProcessmodified amino acid metabolic process

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

3.66e-04218585GO:0006575
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

SFPQ KMT2D MRTFB MED29 PPRC1 MED25 MED14 SUPT20HL2 TAF4 FOXA2 CREBBP FOXC2

4.11e-0413905812GO:0045944
GeneOntologyBiologicalProcesspositive regulation of transcription elongation by RNA polymerase II

MED29 MED25 MED14

4.73e-0454583GO:0032968
GeneOntologyBiologicalProcesshippo signaling

LATS1 TIAL1 STRIP1

4.99e-0455583GO:0035329
GeneOntologyBiologicalProcessalpha-amino acid metabolic process

GGTLC1 SLC45A2 GGTLC2 GGT2P GGT1

6.95e-04251585GO:1901605
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription, elongation

MED29 MED25 MED14

7.09e-0462583GO:0032786
GeneOntologyBiologicalProcessnegative regulation of multicellular organism growth

ATXN2 GNAS

1.03e-0317582GO:0040015
GeneOntologyCellularComponentcore mediator complex

MED29 MED25 MED14

5.04e-0526583GO:0070847
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

SFPQ MED29 MED25 MED14 TAF4 CREBBP

1.05e-04272586GO:0090575
GeneOntologyCellularComponenthistone acetyltransferase complex

EP400 SUPT20HL2 TAF4 CREBBP

1.35e-0494584GO:0000123
GeneOntologyCellularComponentmediator complex

MED29 MED25 MED14

1.47e-0437583GO:0016592
GeneOntologyCellularComponentnuclear body

FAM193B SFPQ SATB1 EP400 RAPH1 SETBP1 NUP98 ZC3H18 CREBBP FOXC2

1.70e-049035810GO:0016604
GeneOntologyCellularComponentprotein acetyltransferase complex

EP400 SUPT20HL2 TAF4 CREBBP

2.00e-04104584GO:0031248
GeneOntologyCellularComponenttranscription regulator complex

SFPQ MED29 MED25 MED14 TAF4 FOXA2 MIDEAS CREBBP

2.27e-04596588GO:0005667
GeneOntologyCellularComponentacetyltransferase complex

EP400 SUPT20HL2 TAF4 CREBBP

2.39e-04109584GO:1902493
GeneOntologyCellularComponentnuclear protein-containing complex

SFPQ KMT2D EP400 MED29 BICRA NUP98 MED25 MED14 TAF4 MIDEAS KHDC4 CREBBP

3.34e-0413775812GO:0140513
GeneOntologyCellularComponentchromatin

SFPQ SATB1 ZFHX4 EP400 BICRA SUPT20HL2 TAF4 FOXA2 RFX1 CREBBP HELLS FOXC2

6.40e-0414805812GO:0000785
GeneOntologyCellularComponentcytoplasmic stress granule

YTHDF1 TIAL1 ATXN2

2.41e-0396583GO:0010494
MousePhenoabnormal circulating glutathione level

GGTLC1 GGTLC2 GGT2P GGT1

6.10e-105484MP:0030652
MousePhenoincreased circulating glutathione level

GGTLC1 GGTLC2 GGT2P GGT1

6.10e-105484MP:0030653
MousePhenoglutathionuria

GGTLC1 GGTLC2 GGT2P GGT1

6.10e-105484MP:0013730
MousePhenoincreased glutathione level

GGTLC1 GGTLC2 GGT2P GGT1

6.10e-105484MP:0012606
MousePhenodecreased circulating cysteine level

GGTLC1 GGTLC2 GGT2P GGT1

4.25e-097484MP:0030626
MousePhenoabsent estrous cycle

LATS1 GGTLC1 GGTLC2 FOXA2 GGT2P GGT1

7.59e-0944486MP:0009009
MousePhenodecreased cysteine level

GGTLC1 GGTLC2 GGT2P GGT1

8.48e-098484MP:0030623
MousePhenoepididymis hypoplasia

GGTLC1 GGTLC2 GGT2P GGT1

8.48e-098484MP:0004932
MousePhenonervous

GGTLC1 GGTLC2 GGT2P GGT1

1.52e-089484MP:0008912
MousePhenofailure of copulatory plug deposition

GGTLC1 GGTLC2 GGT2P GGT1

2.53e-0810484MP:0030983
MousePhenoseminal vesicle hypoplasia

GGTLC1 GGTLC2 GGT2P GGT1

2.53e-0810484MP:0005148
MousePhenoovary hypoplasia

GGTLC1 GGTLC2 GGT2P GGT1

2.53e-0810484MP:0005158
MousePhenoabnormal growth hormone level

LATS1 BICRA GGTLC1 GGTLC2 GGT2P GGT1

3.77e-0857486MP:0003968
MousePhenoabnormal circulating cysteine level

GGTLC1 GGTLC2 GGT2P GGT1

3.97e-0811484MP:0030624
MousePhenoabsent tertiary ovarian follicles

GGTLC1 GGTLC2 GGT2P GGT1

3.97e-0811484MP:0011130
MousePhenoabnormal cysteine level

GGTLC1 GGTLC2 GGT2P GGT1

8.55e-0813484MP:0030621
MousePhenodecreased glutathione level

GGTLC1 GGTLC2 GGT2P GGT1

8.55e-0813484MP:0012604
MousePhenoabnormal glutathione level

GGTLC1 GGTLC2 GGT2P GGT1

8.55e-0813484MP:0012603
MousePhenopriapism

GGTLC1 GGTLC2 GGT2P GGT1

1.19e-0714484MP:0003415
MousePhenoabnormal estrous cycle

MAGEL2 LATS1 GGTLC1 GGTLC2 FOXA2 GGT2P GGT1

1.58e-07120487MP:0001927
MousePhenoabnormal copulatory plug deposition

GGTLC1 GGTLC2 GGT2P GGT1

2.16e-0716484MP:0030982
MousePhenodecreased spleen red pulp amount

GGTLC1 GGTLC2 GGT2P GGT1

2.16e-0716484MP:0008477
MousePhenoabnormal ovulation cycle

MAGEL2 LATS1 GGTLC1 GGTLC2 FOXA2 GGT2P GGT1

2.21e-07126487MP:0009344
MousePhenoshort femur

ZFHX4 GGTLC1 GGTLC2 GNAS GGT2P GGT1 HELLS

2.34e-07127487MP:0003109
MousePhenodecreased femur size

ZFHX4 GGTLC1 GGTLC2 GNAS GGT2P GGT1 HELLS

2.74e-07130487MP:0030825
MousePhenofailure of superovulation

GGTLC1 GGTLC2 GGT2P GGT1

3.61e-0718484MP:0031422
MousePhenoabnormal penile erection

GGTLC1 GGTLC2 GGT2P GGT1

3.61e-0718484MP:0001379
MousePhenooocyte degeneration

GGTLC1 GGTLC2 GGT2P GGT1

3.61e-0718484MP:0009093
MousePhenoincreased circulating growth hormone level

GGTLC1 GGTLC2 GGT2P GGT1

4.57e-0719484MP:0005123
MousePhenoabnormal copulation physiology

GGTLC1 GGTLC2 GGT2P GGT1

4.57e-0719484MP:0031627
MousePhenoabsent erythrocytes

EP400 RAPGEF2 MIDEAS

7.54e-076483MP:0000215
MousePhenosmall vertebrae

GGTLC1 GGTLC2 GGT2P GGT1

8.55e-0722484MP:0004610
MousePhenodecreased length of long bones

ZFHX4 GGTLC1 AAK1 MED25 LTBP3 GGTLC2 GNAS GGT2P GGT1 HELLS

9.97e-074094810MP:0004686
MousePhenoincreased growth hormone level

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-0623484MP:0005137
MousePhenouterus hypoplasia

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-0623484MP:0001121
MousePhenoabnormal copulation behavior

GGTLC1 GGTLC2 GGT2P GGT1

1.24e-0624484MP:0009697
MousePhenonuclear cataract

GGTLC1 GGTLC2 GGT2P GGT1

1.73e-0626484MP:0010254
MousePhenodecreased circulating gonadotropin level

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

1.83e-0660485MP:0003363
MousePhenodecreased circulating testosterone level

MAGEL2 GGTLC1 GGTLC2 GGT2P GGT1

1.83e-0660485MP:0002780
MousePhenoimpaired ovarian folliculogenesis

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

1.98e-0661485MP:0001129
MousePhenodecreased pituitary hormone level

LATS1 BICRA GGTLC1 GGTLC2 GGT2P GGT1

2.27e-06113486MP:0003972
MousePhenodiluted coat color

GGTLC1 SLC45A2 GGTLC2 GGT2P GGT1

2.52e-0664485MP:0000371
MousePhenoabnormal corpus luteum morphology

MAGEL2 LATS1 GGTLC1 GGTLC2 GGT2P GGT1

2.65e-06116486MP:0002679
MousePhenoaminoaciduria

GGTLC1 GGTLC2 GGT2P GGT1

2.73e-0629484MP:0003311
MousePhenoabsent corpus luteum

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

2.94e-0666485MP:0001134
MousePhenoabnormal long bone epiphyseal plate proliferative zone

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

3.42e-0668485MP:0003662
MousePhenoanovulation

GGTLC1 GGTLC2 GGT2P GGT1

4.65e-0633484MP:0008869
MousePhenodecreased circulating follicle stimulating hormone level

GGTLC1 GGTLC2 GGT2P GGT1

5.26e-0634484MP:0002790
MousePhenohindlimb paralysis

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

7.18e-0679485MP:0000755
MousePhenodecreased hormone level

MAGEL2 LATS1 BICRA GGTLC1 GGTLC2 GNAS FOXA2 NNT CREBBP GGT2P GGT1

7.58e-066354811MP:0014455
MousePhenoabnormal femur morphology

ZFHX4 GGTLC1 GGTLC2 GNAS GGT2P GGT1 HELLS

7.72e-06214487MP:0000559
MousePhenoabnormal hindlimb stylopod morphology

ZFHX4 GGTLC1 GGTLC2 GNAS GGT2P GGT1 HELLS

7.96e-06215487MP:0003856
MousePhenodecreased circulating estradiol level

GGTLC1 GGTLC2 GGT2P GGT1

8.29e-0638484MP:0005181
MousePhenolimb paralysis

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

9.16e-0683485MP:0013147
MousePhenodecreased tertiary ovarian follicle number

GGTLC1 GGTLC2 GGT2P GGT1

9.21e-0639484MP:0011129
MousePhenoabnormal circulating testosterone level

MAGEL2 GGTLC1 GGTLC2 GGT2P GGT1

9.71e-0684485MP:0005180
MousePhenoabnormal circulating androgen level

MAGEL2 GGTLC1 GGTLC2 GGT2P GGT1

9.71e-0684485MP:0009819
MousePhenoabnormal spine curvature

MAGEL2 GGTLC1 LTBP3 GGTLC2 CREBBP GGT2P GGT1 HELLS

1.12e-05318488MP:0004174
MousePhenodecreased circulating estrogen level

GGTLC1 GGTLC2 GGT2P GGT1

1.13e-0541484MP:0003371
MousePhenoinduced hyperactivity

GGTLC1 GGTLC2 GGT2P GGT1

1.24e-0542484MP:0008911
MousePhenodecreased circulating pituitary hormone level

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

1.29e-0589485MP:0005118
MousePhenodecreased circulating hormone level

MAGEL2 LATS1 GGTLC1 GGTLC2 GNAS FOXA2 NNT CREBBP GGT2P GGT1

1.41e-055514810MP:0014457
MousePhenodecreased follicle stimulating hormone level

GGTLC1 GGTLC2 GGT2P GGT1

1.50e-0544484MP:0005130
MousePhenodecreased long bone epiphyseal plate size

GGTLC1 GGTLC2 GGT2P GGT1

1.50e-0544484MP:0006396
MousePhenoabnormal testosterone level

MAGEL2 GGTLC1 GGTLC2 GGT2P GGT1

1.52e-0592485MP:0011385
MousePhenoabnormal tertiary ovarian follicle number

GGTLC1 GGTLC2 GGT2P GGT1

1.96e-0547484MP:0011127
MousePhenodecreased bone mass

GGTLC1 GGTLC2 GGT2P GGT1 HELLS

2.27e-05100485MP:0004016
MousePhenodecreased thyroxine level

GGTLC1 GGTLC2 GGT2P GGT1

2.72e-0551484MP:0005471
MousePhenoabnormal circulating estradiol level

GGTLC1 GGTLC2 GGT2P GGT1

2.93e-0552484MP:0005183
MousePhenoaciduria

GGTLC1 GGTLC2 GGT2P GGT1

3.67e-0555484MP:0010028
MousePhenoshort tibia

GGTLC1 AAK1 MED25 GGTLC2 GGT2P GGT1 HELLS

3.81e-05274487MP:0002764
MousePhenoabnormal circulating gonadotropin level

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

3.93e-05112485MP:0003361
MousePhenoabnormal long bone hypertrophic chondrocyte zone

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

4.10e-05113485MP:0000165
MousePhenodecreased circulating glucagon level

GNAS FOXA2 CREBBP

4.16e-0520483MP:0002696
MousePhenoabnormal circulating estrogen level

GGTLC1 GGTLC2 GGT2P GGT1

4.23e-0557484MP:0003369
MousePhenoabnormal tertiary ovarian follicle morphology

GGTLC1 GGTLC2 GGT2P GGT1

4.23e-0557484MP:0009363
MousePhenodisproportionate dwarf

GGTLC1 GGTLC2 GGT2P GGT1

4.23e-0557484MP:0002427
MousePhenoperinatal lethality, incomplete penetrance

MAGEL2 MRTFB LATS1 PDLIM7 FUBP1 GNAS FOXA2 CREBBP HELLS

4.51e-05503489MP:0011090
MousePhenoabnormal urine amino acid level

GGTLC1 GGTLC2 GGT2P GGT1

4.85e-0559484MP:0011468
MousePhenoimmotile sperm

GGTLC1 GGTLC2 GGT2P GGT1

4.85e-0559484MP:0020869
MousePhenoparalysis

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

5.25e-05119485MP:0000753
MousePhenoabnormal ovarian folliculogenesis

LATS1 GGTLC1 GGTLC2 GGT2P GGT1

5.47e-05120485MP:0001130
MousePhenodecreased circulating insulin-like growth factor I level

GGTLC1 GGTLC2 GGT2P GGT1

5.53e-0561484MP:0004701
MousePhenoabnormal ovarian follicle number

LATS1 TIAL1 GGTLC1 GGTLC2 GGT2P GGT1

6.43e-05203486MP:0008871
MousePhenoabnormal superovulation

GGTLC1 GGTLC2 GGT2P GGT1

7.54e-0566484MP:0009648
MousePhenoabnormal thyroxine level

GGTLC1 GGTLC2 GGT2P GGT1

7.54e-0566484MP:0005469
MousePhenoabnormal long bone morphology

ZFHX4 GGTLC1 AAK1 MED25 LTBP3 GGTLC2 GNAS GGT2P GGT1 HELLS

8.06e-056764810MP:0003723
MousePhenoabnormal pituitary hormone level

LATS1 BICRA GGTLC1 GGTLC2 GGT2P GGT1

8.61e-05214486MP:0003965
MousePhenosmall epididymis

GGTLC1 GGTLC2 GGT2P GGT1

9.50e-0570484MP:0004930
MousePhenoabnormal circulating insulin-like growth factor I level

GGTLC1 GGTLC2 GGT2P GGT1

1.06e-0472484MP:0004700
MousePhenohyperactivity

KMT2D SATB1 ATXN2 KCNJ3 GGTLC1 AAK1 SLC45A2 GGTLC2 GNAS FOXA2 CREBBP GGT2P GGT1

1.13e-0411724813MP:0001399
MousePhenoabnormal limb long bone morphology

ZFHX4 GGTLC1 AAK1 MED25 GGTLC2 GNAS GGT2P GGT1 HELLS

1.15e-04568489MP:0011504
MousePhenoabnormal thyroid hormone level

GGTLC1 GGTLC2 GGT2P GGT1

1.18e-0474484MP:0005468
MousePhenoabnormal insulin-like growth factor I level

GGTLC1 GGTLC2 GGT2P GGT1

1.24e-0475484MP:0008831
MousePhenokyphosis

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1 HELLS

1.25e-04229486MP:0000160
MousePhenoabnormal skeleton development

GGTLC1 LTBP3 GGTLC2 CREBBP GGT2P GGT1 HELLS FOXC2

1.26e-04447488MP:0002113
MousePhenoabnormal hindlimb morphology

ZFHX4 GGTLC1 AAK1 MED25 GGTLC2 GNAS GGT2P GGT1 HELLS

1.28e-04576489MP:0000556
MousePhenoabnormal cartilage morphology

ZFHX4 GGTLC1 LTBP3 GGTLC2 GGT2P GGT1 FOXC2

1.37e-04336487MP:0000163
MousePhenoincreased osteoclast cell number

GGTLC1 GGTLC2 GGT2P GGT1

1.38e-0477484MP:0004984
MousePhenoabnormal seminal vesicle size

ATXN2 GGTLC1 GGTLC2 GGT2P GGT1

1.48e-04148485MP:0004907
DomainGGT_peptidase

GGTLC1 GGTLC2 GGT1

8.86e-077563IPR000101
DomainG_GLU_TRANSPEPTIDASE

GGTLC1 GGTLC2 GGT1

8.86e-077563PS00462
DomainG_glu_transpept

GGTLC1 GGTLC2 GGT1

8.86e-077563PF01019
DomainNtn_hydrolases_N

GGTLC1 GGTLC2 GGT1

1.31e-0433563IPR029055
DomainPDZ

PDLIM7 PCLO RAPGEF2 SHROOM2

1.09e-03151564PS50106
DomainPDZ

PDLIM7 PCLO RAPGEF2 SHROOM2

1.11e-03152564IPR001478
DomainRA

RAPH1 RAPGEF2

3.88e-0331562SM00314
DomainSNF2_N

EP400 HELLS

4.13e-0332562IPR000330
DomainSNF2_N

EP400 HELLS

4.13e-0332562PF00176
DomaincNMP

CNGB3 RAPGEF2

4.66e-0334562SM00100
DomaincNMP_binding

CNGB3 RAPGEF2

4.66e-0334562PF00027
DomaincNMP-bd_dom

CNGB3 RAPGEF2

4.93e-0335562IPR000595
DomainCNMP_BINDING_3

CNGB3 RAPGEF2

4.93e-0335562PS50042
DomainRA

RAPH1 RAPGEF2

5.21e-0336562PF00788
DomainRA

RAPH1 RAPGEF2

5.50e-0337562PS50200
DomainMYB_LIKE

EP400 MIDEAS

5.79e-0338562PS50090
DomaincNMP-bd-like

CNGB3 RAPGEF2

5.79e-0338562IPR018490
PathwayREACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING

GGTLC1 GGTLC2 GGT2P GGT1

1.09e-0716414MM14680
PathwayWP_EICOSANOID_SYNTHESIS

GGTLC1 GGTLC2 GGT2P GGT1

4.34e-0722414MM15961
PathwayWP_OXYLIPINS_PATHWAYS

GGTLC1 GGTLC2 GGT2P GGT1

6.27e-0724414MM17249
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

GGTLC1 GGTLC2 GGT2P GGT1

7.45e-0725414MM14858
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

GGTLC1 GGTLC2 GGT2P GGT1

8.79e-0726414MM15190
PathwayWP_GLUTATHIONE_METABOLISM

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-0627414MM15908
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

GGTLC1 GGTLC2 GGT2P GGT1

2.37e-0633414MM15963
PathwayWP_GLUTATHIONE_AND_ONECARBON_METABOLISM

GGTLC1 GGTLC2 GGT2P GGT1

3.02e-0635414MM15815
PathwayREACTOME_GLUTATHIONE_CONJUGATION

GGTLC1 GGTLC2 GGT2P GGT1

4.23e-0638414MM14600
PathwayREACTOME_PARACETAMOL_ADME

GGTLC1 GGTLC2 GGT2P GGT1

4.71e-0639414MM15695
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

GGTLC1 GGTLC2 GGT2P GGT1

2.85e-0561414MM14861
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

MED29 MED25 MED14 CREBBP

1.00e-0484414M1008
PathwayWP_OXIDATIVE_STRESS_AND_REDOX_PATHWAY

GGTLC1 GGTLC2 GGT2P GGT1

1.43e-0492414MM15823
PathwayREACTOME_RSV_HOST_INTERACTIONS

MED29 MED25 MED14 CREBBP

1.83e-0498414M48247
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

GGTLC1 GGTLC2 GGT2P GGT1

2.56e-04107414MM14595
PathwayREACTOME_ADIPOGENESIS

MED29 MED25 MED14 CREBBP

2.85e-04110414M48259
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

MED29 MED25 MED14 CREBBP

3.72e-04118414M27316
PathwayREACTOME_DRUG_ADME

GGTLC1 GGTLC2 GGT2P GGT1

3.84e-04119414MM15692
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

MED29 MED25 MED14 CREBBP

3.96e-04120414M48233
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

LATS1 ZFHX4 FOXA2 FOXC2

9.89e-04153414M39546
PathwayREACTOME_FATTY_ACID_METABOLISM

GGTLC1 GGTLC2 GGT2P GGT1

1.46e-03170414MM15573
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

KMT2D SATB1 EP400 CREBBP HELLS

1.71e-03301415MM15983
Pubmed

The human gamma-glutamyltransferase gene family.

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

2.55e-111460518357469
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560418063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560410940879
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560411095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156047641802
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560423615310
Pubmed

The mouse skin carcinogenesis model.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156049627710
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560412453183
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560411003618
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560410392451
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156042891746
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560419850887
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560412810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156048755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560411089562
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560428660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560412468440
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560426977590
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560412225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156047775425
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156048566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560430591459
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156049139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560420622017
Pubmed

Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156049546365
Pubmed

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560411795900
Pubmed

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156047485380
Pubmed

Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560410751614
Pubmed

Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-1156047523374
Pubmed

Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560424698228
Pubmed

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560425132819
Pubmed

Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560419760322
Pubmed

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.

GGTLC1 GGTLC2 GGT2P GGT1

4.00e-11560410474818
Pubmed

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660414634009
Pubmed

Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660417363454
Pubmed

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-1066048101000
Pubmed

Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-1066048663190
Pubmed

Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-1066048104871
Pubmed

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660411463821
Pubmed

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660425326709
Pubmed

Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660412163373
Pubmed

Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

GGTLC1 GGTLC2 GGT2P GGT1

1.20e-10660422242126
Pubmed

γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.

GGTLC1 GGTLC2 GGT2P GGT1

2.79e-10760427775020
Pubmed

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

GGTLC1 GGTLC2 GGT2P GGT1

2.79e-10760432284594
Pubmed

Defective epidermal growth factor gene expression in mice with polycystic kidney disease.

GGTLC1 GGTLC2 GGT2P GGT1

2.79e-1076041968405
Pubmed

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.

GGTLC1 GGTLC2 GGT2P GGT1

2.79e-10760436685533
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

SFPQ KMT2D TIAL1 EP400 MED29 ATXN2 BICRA FUBP1 MED14 TAF4 RFX1 MIDEAS KHDC4 CREBBP HELLS

4.21e-101103601534189442
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

KMT2D EP400 MED29 MED25 MED14 TAF4 MIDEAS HELLS

4.94e-1016760820362541
Pubmed

Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.

GGTLC1 GGTLC2 FOXA2 GGT2P GGT1

1.01e-092760518478268
Pubmed

Human transcription factor protein interaction networks.

YTHDF1 KMT2D SATB1 ZFHX4 EP400 ATXN2 BICRA FUBP1 NUP98 R3HDM2 ZC3H18 TAF4 RFX1 MIDEAS CREBBP HELLS

1.64e-091429601635140242
Pubmed

Renalase regulates renal dopamine and phosphate metabolism.

GGTLC1 GGTLC2 GGT2P GGT1

1.67e-091060423863468
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2D MRTFB LATS1 EP400 RAPH1 PDLIM7 MED14 TAF4 RFX1 MIDEAS CREBBP

2.34e-09549601138280479
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

MAGEL2 MRTFB LATS1 EP400 ATXN2 PDLIM7 BICRA KCNJ3 SETBP1 NUP98

3.27e-09430601035044719
Pubmed

Human lung expresses unique gamma-glutamyl transpeptidase transcripts.

GGTLC1 GGTLC2 GGT1

4.88e-0936037689219
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

YTHDF1 SFPQ KMT2D ATXN2 FUBP1 NUP98 FOXA2 MIDEAS KHDC4 CREBBP

5.83e-09457601032344865
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIP2B KMT2D LATS1 EP400 RAPH1 FUBP1 NUP98 AAK1 MED14 ZC3H18 RFX1 STRIP1

7.14e-09774601215302935
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

YTHDF1 SFPQ TIAL1 EP400 ATXN2 BICRA FUBP1 NUP98 ZC3H18 TAF4 RFX1 MIDEAS HELLS

7.20e-09954601336373674
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

SFPQ TIAL1 BICRA R3HDM2 MIDEAS KHDC4 CREBBP

8.43e-0915260738360978
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2D SATB1 ZFHX4 EP400 BICRA NUP98 TAF4 MIDEAS CREBBP

9.22e-0935160938297188
Pubmed

Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.

GGTLC1 GGTLC2 GGT2P GGT1

2.40e-081860417097888
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

KMT2D MRTFB EP400 FUBP1 MED14 ZC3H18 RFX1 MIDEAS

1.29e-0734160832971831
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

SATB1 ZFHX4 FUBP1 RFX1

1.59e-072860429365100
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DIP2B MRTFB ATXN2 BICRA KCNJ3 FUBP1 SETBP1 AAK1 PDIA5 TAF4 GNAS RAPGEF2 SHROOM2 CREBBP

1.79e-071489601428611215
Pubmed

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

GGTLC1 GGTLC2 GGT2P GGT1

1.84e-072960422424930
Pubmed

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

GGTLC1 GGTLC2 GGT2P GGT1

5.65e-073860427820600
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SFPQ SATB1 EP400 FUBP1 AAK1 TAF4 CREBBP HELLS

9.48e-0744460834795231
Pubmed

Mouse models of ocular diseases.

GGTLC1 GGTLC2 GGT2P GGT1

1.03e-064460416332269
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

SFPQ EP400 FUBP1 MED25 MED14 RFX1 MIDEAS CREBBP

1.10e-0645360829656893
Pubmed

A comprehensive analysis of 22q11 gene expression in the developing and adult brain.

GGTLC1 GGTLC2 GGT2P GGT1

1.13e-064560414614146
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

SFPQ EP400 MED29 FUBP1 NUP98 MED25 MED14 ZC3H18 TAF4 CREBBP HELLS

1.14e-061014601132416067
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

KMT2D SATB1 ZFHX4 EP400 NUP98 FOXA2 RFX1 CREBBP HELLS FOXC2

1.94e-06857601025609649
Pubmed

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

GGTLC1 GGTLC2 GGT2P GGT1

2.75e-065660420096683
Pubmed

Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.

GGT2P GGT1

2.93e-06260225180444
Pubmed

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

GGT2P GGT1

2.93e-06260225280803
Pubmed

Characterization of four novel CAG repeat-containing cDNAs.

KMT2D R3HDM2

2.93e-0626028595911
Pubmed

Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.

GGT2P GGT1

2.93e-06260237904480
Pubmed

Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.

SATB1 CREBBP

2.93e-06260219924292
Pubmed

Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.

GGT2P GGT1

2.93e-06260223682772
Pubmed

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

KMT2D CREBBP

2.93e-06260227999180
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

SFPQ LATS1 FUBP1 ADAM9 GGTLC1 GGTLC2 CREBBP GGT2P GGT1

4.28e-0673060934857952
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED25 MED14 CREBBP

4.64e-061960316799563
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

KMT2D EP400 MED14 RFX1

5.01e-066560422496869
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

MED29 MED25 MED14 CREBBP

5.32e-066660423275444
Pubmed

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

MED29 MED25 MED14 TAF4

7.97e-067360421729782
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED25 MED14 CREBBP

8.43e-062360310235267
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

KMT2D EP400 ATXN2

8.43e-06236039225980
Pubmed

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.

KMT2D CREBBP

8.77e-06360234463256
Pubmed

Function of Nup98 subtypes and their fusion proteins, Nup98-TopIIβ and Nup98-SETBP1 in nuclear-cytoplasmic transport.

SETBP1 NUP98

8.77e-06360228392395
Pubmed

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

EP400 CREBBP

8.77e-0636029590171
Pubmed

Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin.

TAF4 CREBBP

8.77e-06360215703171
Pubmed

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.

KMT2D CREBBP

8.77e-06360236893259
Pubmed

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.

GNAS RAPGEF2

8.77e-06360212391161
Pubmed

Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.

GGT2P GGT1

8.77e-0636022573352
Pubmed

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.

NUP98 CREBBP

8.77e-0636029858599
Pubmed

Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.

MED29 MED25 MED14

1.23e-052660324882805
Pubmed

Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.

MED29 MED25 MED14

1.23e-052660311559591
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

KMT2D SATB1 EP400 MIDEAS

1.33e-058360428794006
Pubmed

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.

MED29 MED25 MED14

1.73e-052960314638676
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2D CREBBP

1.75e-05460228398509
Pubmed

Binding and modulation of p53 by p300/CBP coactivators.

EP400 CREBBP

1.75e-0546029194565
InteractionFEV interactions

KMT2D SATB1 ZFHX4 EP400 BICRA TAF4 RFX1 MIDEAS CREBBP

4.50e-09203569int:FEV
InteractionGGT2P interactions

GGTLC1 GGT2P GGT1

2.03e-083563int:GGT2P
InteractionSP7 interactions

KMT2D SATB1 ZFHX4 EP400 BICRA FUBP1 RFX1 MIDEAS CREBBP

1.46e-07304569int:SP7
InteractionNFIX interactions

KMT2D ZFHX4 EP400 BICRA TAF4 RFX1 MIDEAS NNT

2.04e-07227568int:NFIX
InteractionNUP35 interactions

YTHDF1 SFPQ KMT2D ATXN2 FUBP1 NUP98 FOXA2 MIDEAS KHDC4 CREBBP

2.29e-074245610int:NUP35
InteractionEYA4 interactions

SFPQ TIAL1 BICRA AAK1 R3HDM2 MIDEAS KHDC4 CREBBP

3.43e-07243568int:EYA4
InteractionGGT1 interactions

GGTLC1 GGTLC2 GGT2P GGT1

6.48e-0725564int:GGT1
InteractionDZIP3 interactions

YTHDF1 SFPQ TIAL1 ATXN2 RABGAP1L R3HDM2 TAF4

7.23e-07183567int:DZIP3
InteractionGATA3 interactions

KMT2D SATB1 ZFHX4 FUBP1 MIDEAS NNT CREBBP

8.36e-07187567int:GATA3
InteractionHNF4A interactions

KMT2D EP400 BICRA MED14 TAF4 FOXA2 MIDEAS CREBBP

8.75e-07275568int:HNF4A
InteractionHNF1B interactions

KMT2D SATB1 ZFHX4 EP400 BICRA MIDEAS CREBBP

9.30e-07190567int:HNF1B
InteractionCEBPA interactions

SFPQ KMT2D TIAL1 EP400 MED29 ATXN2 BICRA FUBP1 MED14 TAF4 RFX1 MIDEAS KHDC4 CREBBP HELLS

9.85e-0712455615int:CEBPA
InteractionGGTLC1 interactions

GGTLC1 GGT2P GGT1

1.13e-068563int:GGTLC1
InteractionSMC5 interactions

YTHDF1 SFPQ TIAL1 EP400 ATXN2 BICRA FUBP1 NUP98 ZC3H18 TAF4 RFX1 MIDEAS HELLS

2.64e-0610005613int:SMC5
InteractionMEN1 interactions

YTHDF1 SFPQ KMT2D MRTFB TIAL1 EP400 FUBP1 SETBP1 NUP98 MED14 ZC3H18 RFX1 MIDEAS

3.62e-0610295613int:MEN1
InteractionGSC interactions

KMT2D ZFHX4 FOXA2 MIDEAS CREBBP

4.29e-0687565int:GSC
InteractionYAP1 interactions

SFPQ KMT2D MRTFB LATS1 PDLIM7 FUBP1 MED14 TAF4 GNAS RAPGEF2 RFX1 MIDEAS CREBBP

7.12e-0610955613int:YAP1
InteractionEGR2 interactions

KMT2D ZFHX4 EP400 BICRA MIDEAS CREBBP

7.81e-06171566int:EGR2
InteractionFOXL1 interactions

KMT2D SATB1 ZFHX4 NUP98 MIDEAS HELLS

1.70e-05196566int:FOXL1
InteractionTBXT interactions

KMT2D SATB1 ZFHX4 MIDEAS CREBBP

1.75e-05116565int:TBXT
InteractionFUBP3 interactions

YTHDF1 TIAL1 ATXN2 FUBP1 PDIA5 R3HDM2 ZC3H18

1.76e-05297567int:FUBP3
InteractionGGTLC2 interactions

GGTLC2 GGT1

2.27e-053562int:GGTLC2
InteractionYTHDF2 interactions

YTHDF1 SFPQ MAGEL2 ATXN2 R3HDM2 TAF4 CREBBP

2.41e-05312567int:YTHDF2
InteractionPAX7 interactions

KMT2D SATB1 ZFHX4 MIDEAS CREBBP

2.42e-05124565int:PAX7
InteractionMEX3B interactions

YTHDF1 FAM193B ATXN2 PDLIM7 R3HDM2 STRIP1

3.42e-05222566int:MEX3B
InteractionERG interactions

SFPQ KMT2D ZFHX4 BICRA MIDEAS CREBBP

3.51e-05223566int:ERG
InteractionGCM1 interactions

YTHDF1 KMT2D MIDEAS CREBBP

3.81e-0568564int:GCM1
InteractionHDAC1 interactions

SFPQ KMT2D MRTFB SATB1 ZFHX4 EP400 RAPH1 NUP98 RFX1 MIDEAS CREBBP HELLS

4.23e-0511085612int:HDAC1
InteractionFOXP2 interactions

SATB1 ZFHX4 FUBP1 RFX1

4.28e-0570564int:FOXP2
InteractionFOXQ1 interactions

SATB1 ZFHX4 NUP98 CREBBP HELLS

4.48e-05141565int:FOXQ1
InteractionFAM168A interactions

YTHDF1 LATS1 TIAL1 R3HDM2 STRIP1

4.63e-05142565int:FAM168A
InteractionDAZL interactions

YTHDF1 TIAL1 ATXN2 FUBP1 R3HDM2

5.12e-05145565int:DAZL
InteractionSMAD1 interactions

KMT2D MRTFB MED25 MED14 RFX1 CREBBP

5.67e-05243566int:SMAD1
InteractionPAX6 interactions

KMT2D SATB1 ZFHX4 EP400 BICRA MIDEAS CREBBP

6.64e-05366567int:PAX6
InteractionCRX interactions

KMT2D ZFHX4 EP400 BICRA MIDEAS CREBBP

7.24e-05254566int:CRX
InteractionHOXD13 interactions

RABGAP1L FOXA2 CREBBP FOXC2

7.96e-0582564int:HOXD13
InteractionESRRB interactions

KMT2D EP400 MED29 MED25 MED14 TAF4

8.59e-05262566int:ESRRB
InteractionR3HDM1 interactions

YTHDF1 LATS1 ATXN2 R3HDM2

8.75e-0584564int:R3HDM1
InteractionTLX1 interactions

KMT2D SATB1 ZFHX4 MIDEAS CREBBP

1.24e-04175565int:TLX1
InteractionFOXI1 interactions

KMT2D SATB1 ZFHX4 CREBBP

1.25e-0492564int:FOXI1
InteractionMED7 interactions

EP400 MED29 MED25 MED14

1.25e-0492564int:MED7
InteractionTEAD1 interactions

KMT2D SATB1 ZFHX4 MIDEAS CREBBP

1.28e-04176565int:TEAD1
InteractionMED25 interactions

MED29 MED25 MED14 CREBBP

1.30e-0493564int:MED25
InteractionDYRK1A interactions

SFPQ KMT2D PDLIM7 ADAM9 NUP98 LTBP3 RAPGEF2 CREBBP

1.34e-04552568int:DYRK1A
InteractionPUM1 interactions

YTHDF1 LATS1 TIAL1 ATXN2 FUBP1 R3HDM2

1.41e-04287566int:PUM1
InteractionCELF1 interactions

YTHDF1 SFPQ TIAL1 ATXN2 FUBP1 R3HDM2

1.44e-04288566int:CELF1
InteractionTOPORS interactions

SFPQ SATB1 ZC3H18 CREBBP

1.47e-0496564int:TOPORS
InteractionSOX9 interactions

KMT2D EP400 MIDEAS CREBBP

1.53e-0497564int:SOX9
InteractionALG13 interactions

YTHDF1 KMT2D LATS1 ATXN2 R3HDM2

1.53e-04183565int:ALG13
InteractionLHX2 interactions

KMT2D SATB1 ZFHX4 EP400 HELLS

1.53e-04183565int:LHX2
InteractionFOXP4 interactions

SATB1 ZFHX4 FUBP1 RFX1

1.59e-0498564int:FOXP4
InteractionQKI interactions

YTHDF1 TIAL1 MED29 MED25 MED14

1.83e-04190565int:QKI
InteractionCLOCK interactions

RABGAP1L NUP98 KHDC4 CREBBP

1.86e-04102564int:CLOCK
InteractionLHX1 interactions

KMT2D SATB1 ZFHX4 FOXA2

1.93e-04103564int:LHX1
InteractionGGT5 interactions

GGTLC1 GGT1

2.10e-048562int:GGT5
InteractionTADA2A interactions

SFPQ MED29 PDLIM7 MED25 MED14

2.21e-04198565int:TADA2A
InteractionMED26 interactions

MED29 MED25 MED14 TAF4

2.23e-04107564int:MED26
InteractionGATA2 interactions

KMT2D SATB1 ZFHX4 MIDEAS CREBBP

2.27e-04199565int:GATA2
InteractionEN1 interactions

KMT2D ZFHX4 EP400 MIDEAS

2.48e-04110564int:EN1
InteractionSMG7 interactions

YTHDF1 KMT2D LATS1 ATXN2 R3HDM2 CREBBP

2.50e-04319566int:SMG7
InteractionPAX8 interactions

KMT2D ZFHX4 MIDEAS CREBBP

2.57e-04111564int:PAX8
InteractionTBR1 interactions

KMT2D LATS1 ZFHX4 MIDEAS

2.75e-04113564int:TBR1
InteractionMAGEA9 interactions

SATB1 ZFHX4 TAF4 RAPGEF2 HELLS

2.78e-04208565int:MAGEA9
InteractionLPXN interactions

ATXN2 PDLIM7 GNAS RAPGEF2

2.94e-04115564int:LPXN
InteractionTRRAP interactions

SFPQ TIAL1 EP400 PPRC1 FUBP1 MED25 MED14 TAF4 CREBBP

3.03e-04790569int:TRRAP
InteractionNUP43 interactions

KMT2D MRTFB EP400 NUP98 ZC3H18 TAF4 RAPGEF2 MIDEAS

3.13e-04625568int:NUP43
InteractionONECUT1 interactions

FOXA2 CREBBP

3.36e-0410562int:ONECUT1
InteractionRGPD1 interactions

LATS1 PDLIM7 NUP98

3.42e-0449563int:RGPD1
InteractionRAPGEF4 interactions

PCLO GNAS RAPGEF2

3.63e-0450563int:RAPGEF4
InteractionSF3B4 interactions

YTHDF1 SFPQ MAGEL2 LATS1 TIAL1 ZC3H18

3.63e-04342566int:SF3B4
InteractionMCRIP2 interactions

YTHDF1 ATXN2 R3HDM2

3.85e-0451563int:MCRIP2
InteractionUBE2I interactions

SFPQ LATS1 SATB1 PDLIM7 SETBP1 ZNF837 NUP98 CREBBP

4.23e-04654568int:UBE2I
InteractionMARF1 interactions

YTHDF1 ATXN2 R3HDM2 CREBBP

4.42e-04128564int:MARF1
InteractionIGF2BP2 interactions

YTHDF1 TIAL1 ATXN2 FUBP1 R3HDM2 ZC3H18

4.56e-04357566int:IGF2BP2
InteractionPAX9 interactions

KMT2D SATB1 ZFHX4 MIDEAS

4.68e-04130564int:PAX9
InteractionOTUD4 interactions

YTHDF1 LATS1 TIAL1 ATXN2 R3HDM2

4.96e-04236565int:OTUD4
InteractionPRR13 interactions

TIAL1 FUBP1 KHDC4

5.08e-0456563int:PRR13
InteractionHDAC2 interactions

SFPQ SATB1 EP400 FUBP1 ZC3H18 MIDEAS CREBBP HELLS FOXC2

5.86e-04865569int:HDAC2
InteractionTOP3B interactions

YTHDF1 FAM193B KMT2D EP400 ATXN2 PPRC1 BICRA MED14 PDIA5 R3HDM2 LTBP3 GNAS

5.97e-0414705612int:TOP3B
InteractionNFIB interactions

KMT2D RFX1 MIDEAS CREBBP

6.53e-04142564int:NFIB
InteractionTP53BP1 interactions

SFPQ EP400 FUBP1 MED25 MED14 RFX1 CREBBP

6.57e-04533567int:TP53BP1
InteractionSMARCC1 interactions

SFPQ LATS1 BICRA FUBP1 CREBBP STRIP1

6.69e-04384566int:SMARCC1
InteractionFMR1 interactions

YTHDF1 DIP2B SFPQ TIAL1 ATXN2 FUBP1 RAPGEF2

6.79e-04536567int:FMR1
InteractionPRRC2A interactions

YTHDF1 SFPQ TIAL1 ATXN2 R3HDM2 ZC3H18

7.16e-04389566int:PRRC2A
InteractionELF5 interactions

KMT2D SATB1 ZC3H18 MIDEAS

7.43e-04147564int:ELF5
InteractionFHL2 interactions

SFPQ MAGEL2 MRTFB EP400 RFX1 CREBBP

7.85e-04396566int:FHL2
InteractionSREBF1 interactions

MED25 MED14 KHDC4 CREBBP

8.02e-04150564int:SREBF1
InteractionWDR5 interactions

SFPQ KMT2D PDLIM7 SETBP1 NUP98 PDIA5 ZC3H18 TAF4 CREBBP HELLS

8.14e-0411015610int:WDR5
InteractionMED23 interactions

EP400 MED29 MED25 MED14 CREBBP

8.51e-04266565int:MED23
InteractionCPEB4 interactions

YTHDF1 TIAL1 ATXN2 R3HDM2

9.28e-04156564int:CPEB4
InteractionTRO interactions

TIAL1 RABGAP1L GNAS

9.35e-0469563int:TRO
InteractionS100A2 interactions

FAM193B KMT2D LATS1 SATB1 MED29 HELLS

9.64e-04412566int:S100A2
InteractionZC3H13 interactions

MED29 MED25 MED14 ZC3H18

9.73e-04158564int:ZC3H13
InteractionMED21 interactions

MED29 MED25 MED14 CREBBP

9.96e-04159564int:MED21
InteractionMED11 interactions

MED29 MED25 MED14

1.02e-0371563int:MED11
InteractionMOB1A interactions

LATS1 NUP98 CREBBP

1.06e-0372563int:MOB1A
InteractionTNRC6A interactions

YTHDF1 SFPQ LATS1 MED14 R3HDM2

1.07e-03280565int:TNRC6A
InteractionWWTR1 interactions

KMT2D LATS1 EP400 RAPH1 PDLIM7 CREBBP

1.09e-03422566int:WWTR1
InteractionDUXB interactions

ZFHX4 MIDEAS

1.13e-0318562int:DUXB
InteractionFOXN2 interactions

FOXA2 RFX1

1.13e-0318562int:FOXN2
CytobandEnsembl 112 genes in cytogenetic band chr22q11

GGTLC3 GGTLC2 GGT2P GGT1 FAM246C

2.42e-04419615chr22q11
Cytoband12q13.12

DIP2B KMT2D

1.18e-033861212q13.12
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

5.91e-1113415564
GeneFamilyAtaxins|Trinucleotide repeat containing

KMT2D EP400 ATXN2

2.40e-0525413775
GeneFamilyCyclins|Mediator complex

MED29 MED25 MED14

5.63e-05334131061
GeneFamilyPDZ domain containing

PDLIM7 PCLO RAPGEF2 SHROOM2

3.82e-041524141220
GeneFamilyForkhead boxes

FOXA2 FOXC2

4.27e-0343412508
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

EP400 MIDEAS

6.43e-0353412532
GeneFamilyRNA binding motif containing

SFPQ TIAL1 PPRC1

1.24e-02213413725
CoexpressionBAUS_TFF2_TARGETS_UP

GGTLC1 GGTLC2 GGT2P GGT1

4.25e-0649584MM1287
CoexpressionHUMMERICH_SKIN_CANCER_PROGRESSION_DN

GGTLC1 LTBP3 GGTLC2 GGT2P GGT1

4.77e-06111585MM1111
CoexpressionGSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP

FAM193B TIAL1 FUBP1 NUP98 AAK1 LTBP3

5.33e-06200586M9889
CoexpressionANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_1DY_DN

KMT2D TAF4 MIDEAS CREBBP

3.82e-0585584M41085
CoexpressionGAVIN_FOXP3_TARGETS_CLUSTER_P3

RABGAP1L GGTLC1 GGTLC2 GGT2P GGT1

4.08e-05173585MM725
CoexpressionEIF4E_DN

DIP2B MRTFB EP400 ADAM9

7.22e-05100584M2790
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

ATXN2 FUBP1 NUP98 R3HDM2 TAF4 RAPGEF2 CREBBP

7.38e-05466587M13522
CoexpressionGSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN

KMT2D ZC3H18 TAF4 RAPGEF2 RFX1

7.93e-05199585M9443
CoexpressionLIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_XDGS_UP

GGTLC1 GGTLC2 GGT2P GGT1

9.74e-05108584MM1334
CoexpressionCADWELL_ATG16L1_TARGETS_UP

GGTLC1 GGTLC2 GGT2P GGT1

1.28e-04116584MM1240
CoexpressionRIGGINS_TAMOXIFEN_RESISTANCE_DN

ADAM9 RABGAP1L LTBP3 RAPGEF2 NNT

1.30e-04221585M15835
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB1 ATXN2 FUBP1 AAK1 MED14 SLC45A2

1.68e-07185596a2cae8c657e4f4d121476798e424876f7e247973
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB1 ATXN2 FUBP1 AAK1 MED14 SLC45A2

1.68e-07185596d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MRTFB KCNJ3 PCLO SETBP1 GNAS

6.48e-061985958ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

MRTFB KCNJ3 PCLO SETBP1 AAK1

6.80e-0620059548d801219bc771d6c7e151dc88ca4c179988de85
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

SFPQ EP400 KCNJ3 PCLO MED14 NNT

9.08e-061915864168_DN
DrugAlfadolone acetate [23930-37-2]; Down 200; 10.2uM; HL60; HT_HG-U133A

LATS1 ZFHX4 PCLO RABGAP1L AAK1 LTBP3

1.08e-051975863127_DN
DrugAG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A

PDLIM7 RABGAP1L CNGB3 AAK1 MED25 GNAS

1.11e-051985866557_DN
Drug1-ethynylanthracene

SLC45A2 RFX1

1.91e-053582CID012506459
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

4.71e-137575DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGTLC3 GGTLC1 GGTLC2 GGT2P GGT1

1.25e-128575DOID:0050741 (biomarker_via_orthology)
Diseaseacute myeloid leukemia (implicated_via_orthology)

NUP98 CREBBP

2.39e-0412572DOID:9119 (implicated_via_orthology)
Diseaseactinic keratosis

SLC45A2 MMP24OS

3.29e-0414572EFO_0002496
DiseaseLymphoma, Large-Cell, Follicular

KMT2D CREBBP

3.79e-0415572C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

KMT2D CREBBP

3.79e-0415572C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

KMT2D CREBBP

3.79e-0415572C0079758
DiseaseLymphoma, Follicular, Grade 2

KMT2D CREBBP

3.79e-0415572C1956132
DiseaseLymphoma, Follicular, Grade 3

KMT2D CREBBP

3.79e-0415572C1956131
DiseaseLymphoma, Follicular, Grade 1

KMT2D CREBBP

3.79e-0415572C1956130
Diseasenicotine dependence symptom count, depressive symptom measurement

MRTFB LATS1 PCLO

4.18e-0475573EFO_0007006, EFO_0009262
DiseaseLymphoma, Follicular

KMT2D CREBBP

6.81e-0420572C0024301
DiseaseAdenocarcinoma of lung (disorder)

LATS1 SATB1 CREBBP HELLS

6.82e-04206574C0152013
Diseasegastric ulcer

GNAS GGT1

7.52e-0421572EFO_0009454
Diseaseglucose measurement

ATXN2 PDIA5 R3HDM2 FOXA2 RFX1

8.34e-04380575EFO_0004468
Diseasecystatin C measurement

ATXN2 GGTLC1 R3HDM2 GNAS FOXA2

1.07e-03402575EFO_0004617
Diseasefibrinogen measurement

DIP2B ATXN2 PDIA5

1.24e-03109573EFO_0004623
DiseaseSezary Syndrome

KMT2D CREBBP

1.25e-0327572C0036920
Diseaseright ventricular diastolic volume measurement

TIAL1 ATXN2

1.34e-0328572EFO_0021814
DiseasePigmented Basal Cell Carcinoma

LATS1 SLC45A2

1.34e-0328572C1368275
DiseaseCarcinoma, Basal Cell

LATS1 SLC45A2

1.44e-0329572C4721806
Diseasenon-melanoma skin carcinoma

ZFHX4 SLC45A2 MMP24OS NNT

1.73e-03265574EFO_0009260
Diseasedihydroxy docosatrienoic acid measurement

NUP98 AAK1

1.75e-0332572EFO_0005275
Diseasepeptic ulcer disease

GNAS GGT1

1.86e-0333572MONDO_0004247

Protein segments in the cluster

PeptideGeneStartEntry
PQPILTPGQPQKIPT

GNAS

336

P84996
TPGQPQKIPTPGQHQ

GNAS

341

P84996
PPPGPQTTPRTAQQN

FAM246C

191

P0DSO1
KTQQPNVPIPAPPSS

EP400

631

Q96L91
QPLPQTQAKQPQAPP

AAK1

426

Q2M2I8
QQQPTPVHAQPPGTP

CREBBP

946

Q92793
NVPNGPQPPQNPSMV

R3HDM2

711

Q9Y2K5
QPLKPVPANVAPQSP

RAPH1

881

Q70E73
ALNGKPAPPPQSQSP

NUP98

921

P52948
PVRKCNGQPVPFQQP

HELLS

201

Q9NRZ9
VPQGPQAPPAQLATP

MAGEL2

351

Q9UJ55
NVVPAGTVNRQPPPP

LATS1

361

O95835
QQQAQPPPAAPAGAP

FUBP1

546

Q96AE4
QQQPPPAAANVRKPG

ATXN2

186

Q99700
QTQPQPQPQPAAPEG

MMP24OS

16

A0A0U1RRL7
LQQQPPKPIPKQQGP

PCLO

211

Q9Y6V0
IQQPTPGKPPAQQPG

PCLO

306

Q9Y6V0
PLAQQPGTVKPPVQP

PCLO

341

Q9Y6V0
PAQQPGPAKPPTQQV

PCLO

401

Q9Y6V0
PQQPGSAKPPSQQPG

PCLO

491

Q9Y6V0
SQQPGSTKPPPQQPG

PCLO

501

Q9Y6V0
PQQPGSTKPPSQQPG

PCLO

521

Q9Y6V0
VPPSPANFIQPGKQP

GGTLC1

91

Q9BX51
PLPSLQNGPNTPNKP

MRTFB

831

Q9ULH7
VPQPDPNQPKPEGRQ

DIP2B

306

Q9P265
ATGQPQPQGTAQPPP

MED25

601

Q71SY5
VPPSPANFIQPGKQP

GGTLC2

91

Q14390
PQPQPTPQPGAAAAQ

FOXC2

406

Q99958
PGPQQQPQPPAQLVG

MED29

26

Q9NX70
APPPADSAPQQNGQP

PDLIM7

121

Q9NR12
GTQPLQPAPVTQPPK

RABGAP1L

236

B7ZAP0
APPSPANFIQPGKQP

GGTLC3

91

B5MD39
QPPPQQQPFPKQPGT

MED14

1001

O60244
PQGFQGQQPLQKIPP

ERVK-5

631

Q9HDB9
VPGPQVPPASSQPVQ

FAM193B

66

Q96PV7
PPPQPKVSSQGNLIP

ADAM9

791

Q13443
GPPKPQQLPESPSQA

LTBP3

486

Q9NS15
PPNPVAAFPPQKQQQ

MIDEAS

236

Q6PJG2
QSGYPVVPPPQQPVQ

KHDC4

361

Q7Z7F0
KTALPAGPQPQPQPQ

KHDC4

436

Q7Z7F0
QGEPGALPQQPKAPQ

BICRA

381

Q9NZM4
KNPQPPEETGPVLPQ

SAMD15

371

Q9P1V8
AKGIPPQQTPQDPPL

SLC45A2

246

Q9UMX9
PVVPKEPQNPPANAA

PPRC1

436

Q5VV67
PPSPANFIQPGKQPL

GGT2P

436

P36268
LKNPQPPQPQVPETP

PDIA5

256

Q14554
SPPEPAPSPGQQQQA

FOXA2

331

Q9Y261
PPPAAQLPPIVSQGN

NUTM2D

211

Q5VT03
FPAPTPKNIPQGAPV

NNT

436

Q13423
GQPTPLVIQQPPKPG

TAF4

736

O00268
QATPQAPKPGPVQPL

RFX1

251

P22670
GGPGPLIVNNKQPQP

STRIP1

6

Q5VSL9
GSQQHPPSQKAPNPP

SHROOM2

976

Q13796
QQPVPGNTAEQPPSP

SATB1

271

Q01826
LQQPTAAHPPQPGPQ

SUPT20HL2

676

P0C7V6
PPPTPQVNQGTLGPQ

ADGRD2

26

Q7Z7M1
PNSPQNKPPAAPVIN

CNGB3

111

Q9NQW8
PNQQQQAGKSPPVCP

ZNF837

236

Q96EG3
QQQPPPPPQDSSKPV

SFPQ

96

P23246
SLPQPQQQPPPAHKI

RAPGEF2

1036

Q9Y4G8
ASTAQPQPQPQPPKQ

ZFHX4

2396

Q86UP3
QPSSPSPLQPQGPVK

THSD1

396

Q9NS62
KPQAPAQPPQQSPPQ

SETBP1

1556

Q9Y6X0
QGQAPPPVIPPPNQA

TIAL1

351

Q01085
NKGPVPKAPVPQQAP

YTHDF1

276

Q9BYJ9
PKAPVPQQAPSPQAA

YTHDF1

281

Q9BYJ9
SQQPSTPQQAPPGQP

ZC3H18

791

Q86VM9
TPQQAPPGQPQQGTF

ZC3H18

796

Q86VM9
PPSPANFIQPGKQPL

GGT1

436

P19440
LVQQLSPQPPQGPQG

KMT2D

3786

O14686
NNTGPQPPKPGPVLQ

KMT2D

4166

O14686
PQGPGQDPQQQLVPK

KCNJ3

26

P48549