Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	2.91e-05	4	46	2	GO:0035583
GeneOntologyBiologicalProcess	chemical homeostasis	NPC1 GPLD1 ABCB11 SLC9A8 FBN1 FBN2 MBD5 NFAT5 TSPOAP1 STAT3 DMXL1	7.18e-05	1249	46	11	GO:0048878
GeneOntologyBiologicalProcess	pulmonary artery morphogenesis	LRP2 JAG1	7.26e-05	6	46	2	GO:0061156
GeneOntologyBiologicalProcess	response to hormone	NPC1 LRP2 GPLD1 ABCB11 NCOA1 C2 FBN1 BRCA1 MBD5 STAT3	8.01e-05	1042	46	10	GO:0009725
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	1.35e-04	8	46	2	GO:0071694
Domain	FBN	FBN1 FBN2	1.70e-05	3	45	2	IPR011398
Domain	cEGF	LRP2 FBN1 FBN2	3.27e-05	26	45	3	IPR026823
Domain	cEGF	LRP2 FBN1 FBN2	3.27e-05	26	45	3	PF12662
Domain	EGF_CA	LRP2 FBN1 FBN2 JAG1	5.41e-05	86	45	4	PF07645
Domain	EGF_Ca-bd_CS	LRP2 FBN1 FBN2 JAG1	8.65e-05	97	45	4	IPR018097
Domain	EGF_CA	LRP2 FBN1 FBN2 JAG1	9.37e-05	99	45	4	PS01187
Domain	ASX_HYDROXYL	LRP2 FBN1 FBN2 JAG1	9.74e-05	100	45	4	PS00010
Domain	TB	FBN1 FBN2	1.18e-04	7	45	2	PF00683
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 FBN1 FBN2 JAG1	1.22e-04	106	45	4	IPR000152
Domain	-	FBN1 FBN2	1.57e-04	8	45	2	3.90.290.10
Domain	TB	FBN1 FBN2	2.02e-04	9	45	2	PS51364
Domain	TB_dom	FBN1 FBN2	2.02e-04	9	45	2	IPR017878
Domain	EGF_CA	LRP2 FBN1 FBN2 JAG1	2.10e-04	122	45	4	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 FBN1 FBN2 JAG1	2.23e-04	124	45	4	IPR001881
Domain	Growth_fac_rcpt_	LRP2 FBN1 FBN2 JAG1	5.35e-04	156	45	4	IPR009030
Domain	hEGF	FBN2 JAG1	2.06e-03	28	45	2	PF12661
Domain	EGF_3	LRP2 FBN1 FBN2 JAG1	2.43e-03	235	45	4	PS50026
Domain	EGF	LRP2 FBN1 FBN2 JAG1	2.43e-03	235	45	4	SM00181
Domain	EGF-like_dom	LRP2 FBN1 FBN2 JAG1	2.99e-03	249	45	4	IPR000742
Domain	EGF_1	LRP2 FBN1 FBN2 JAG1	3.26e-03	255	45	4	PS00022
Domain	EGF-like_CS	LRP2 FBN1 FBN2 JAG1	3.54e-03	261	45	4	IPR013032
Domain	EGF_2	LRP2 FBN1 FBN2 JAG1	3.74e-03	265	45	4	PS01186
Domain	p53-like_TF_DNA-bd	NFAT5 STAT3	7.23e-03	53	45	2	IPR008967
Domain	EGF_extracell	LRP2 JAG1	9.19e-03	60	45	2	IPR013111
Domain	EGF_2	LRP2 JAG1	9.19e-03	60	45	2	PF07974
Pathway	REACTOME_METABOLISM_OF_STEROIDS	NFYC LRP2 ABCB11 NCOA1 TSPOAP1	2.70e-05	154	33	5	M27832
Pathway	WP_IL6_SIGNALING	NCOA1 STAT3 PRDM1	1.35e-04	43	33	3	M39656
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2 JAG1	1.81e-07	9	46	3	12122015
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.71e-06	2	46	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.71e-06	2	46	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	15131124
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.71e-06	2	46	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.71e-06	2	46	2	8791520
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.71e-06	2	46	2	8307578
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.71e-06	2	46	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.71e-06	2	46	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.71e-06	2	46	2	24833718
Pubmed	Role of Jagged1/STAT3 signalling in platinum-resistant ovarian cancer.	STAT3 JAG1	1.71e-06	2	46	2	30993885
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.71e-06	2	46	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	20529844
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.71e-06	2	46	2	23133647
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.71e-06	2	46	2	1852206
Pubmed	High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1.	LRP2 ABCB11	1.71e-06	2	46	2	10556425
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.71e-06	2	46	2	12429739
Pubmed	Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1.	NCOA1 STAT3	1.71e-06	2	46	2	28579428
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.71e-06	2	46	2	12524050
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.71e-06	2	46	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.71e-06	2	46	2	35419902
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.71e-06	2	46	2	10504303
Pubmed	Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation.	NCOA1 STAT3	1.71e-06	2	46	2	15530426
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.71e-06	2	46	2	25524144
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.71e-06	2	46	2	16407178
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.71e-06	2	46	2	10359653
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	5.13e-06	3	46	2	10825173
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	5.13e-06	3	46	2	30201140
Pubmed	STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.	STAT3 PRDM1	5.13e-06	3	46	2	18354204
Pubmed	SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.	FBN1 STAT3	5.13e-06	3	46	2	31201813
Pubmed	Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.	NCOA1 STAT3	5.13e-06	3	46	2	11773079
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	5.13e-06	3	46	2	20855508
Pubmed	B7-H3 is related to tumor progression in ovarian cancer.	STAT3 CD276	5.13e-06	3	46	2	28765941
Pubmed	JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type.	STAT3 PRDM1	5.13e-06	3	46	2	31002364
Pubmed	B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.	STAT3 CD276	5.13e-06	3	46	2	21518725
Pubmed	BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress.	BRCA1 BORA	5.13e-06	3	46	2	24067368
Pubmed	Co-activator SRC-1 is dispensable for transcriptional control by STAT3.	NCOA1 STAT3	5.13e-06	3	46	2	19203349
Pubmed	IL-21 enhances STAT3/Blimp-1 signaling pathway in B cells and contributes to plasma cell differentiation in newly diagnosed patients with myasthenia gravis.	STAT3 PRDM1	5.13e-06	3	46	2	33145710
Pubmed	Expression of the activation markers Blimp1, Foxp1 and pStat3 in extranodal diffuse large B-cell lymphomas.	STAT3 PRDM1	5.13e-06	3	46	2	27924626
Pubmed	BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers.	BRCA1 JAG1	5.13e-06	3	46	2	23863842
Pubmed	Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.	STAT3 CD276	5.13e-06	3	46	2	25684945
Pubmed	Taking the next step forward - Diagnosing inherited infantile cholestatic disorders with next generation sequencing.	NPC1 ABCB11	5.13e-06	3	46	2	25771912
Pubmed	BLIMP-1 and STAT3 counterregulate microRNA-21 during plasma cell differentiation.	STAT3 PRDM1	5.13e-06	3	46	2	22634616
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN1 FBN2 JAG1	5.51e-06	26	46	3	34189436
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	FBN2 LCORL FARS2	7.72e-06	29	46	3	21998595
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	1.03e-05	4	46	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	1.03e-05	4	46	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	1.03e-05	4	46	2	25034023
Pubmed	T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.	STAT3 PRDM1	1.03e-05	4	46	2	32634740
Pubmed	Analysis of gene mutations in children with cholestasis of undefined etiology.	ABCB11 JAG1	1.03e-05	4	46	2	20683201
Pubmed	Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.	BRCA1 STAT3	1.03e-05	4	46	2	11163768
Pubmed	RAD52 aptamer regulates DNA damage repair and STAT3 in BRCA1/BRCA2‑deficient human acute myeloid leukemia.	BRCA1 STAT3	1.03e-05	4	46	2	32945515
Pubmed	Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.	STAT3 JAG1	1.03e-05	4	46	2	27869648
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	1.03e-05	4	46	2	12429738
Pubmed	B7‑H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer.	STAT3 CD276	1.03e-05	4	46	2	26151358
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	1.03e-05	4	46	2	16835936
Pubmed	Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.	STAT3 JAG1	1.03e-05	4	46	2	20038814
Pubmed	DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.	NCOA1 STAT3	1.03e-05	4	46	2	23874500
Pubmed	Human transcription factor protein interaction networks.	NFYC LRP2 NCOA1 GON4L FBN1 FBN2 BRCA1 ZNF644 STAT3 PRDM1	1.40e-05	1429	46	10	35140242
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GON4L NEFH KIF3B NFAT5 TSPOAP1 ZNF644	1.56e-05	407	46	6	12693553
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	1.71e-05	5	46	2	26601954
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	1.71e-05	5	46	2	23493297
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	1.71e-05	5	46	2	12590922
Pubmed	Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.	STAT3 PRDM1	1.71e-05	5	46	2	21159818
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	1.71e-05	5	46	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	1.71e-05	5	46	2	34411563
Pubmed	Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.	STAT3 PRDM1	1.71e-05	5	46	2	20064451
Pubmed	A census of human transcription factors: function, expression and evolution.	NFYC NCOA1 GON4L NFAT5 LCORL ZNF644 STAT3 PRDM1	2.27e-05	908	46	8	19274049
Pubmed	Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.	STAT3 PRDM1	2.56e-05	6	46	2	26750311
Pubmed	Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice.	STAT3 JAG1	2.56e-05	6	46	2	27050391
Pubmed	High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays.	FBN2 JAG1	2.56e-05	6	46	2	18254948
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	2.56e-05	6	46	2	7873879
Pubmed	Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.	STAT3 PRDM1	2.56e-05	6	46	2	31722202
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	NPC1 LRP2 ABCB11	3.37e-05	47	46	3	11208732
Pubmed	Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.	FBN1 JAG1	3.58e-05	7	46	2	29093270
Pubmed	The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression.	NCOA1 STAT3	3.58e-05	7	46	2	17471507
Pubmed	Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.	ABCB11 NCOA1	3.58e-05	7	46	2	21195347
Pubmed	BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.	NCOA1 BRCA1	3.58e-05	7	46	2	16860316
Pubmed	Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung.	STAT3 PRDM1	3.58e-05	7	46	2	32399548
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	3.58e-05	7	46	2	11470817
Pubmed	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.	STAT3 PRDM1	3.58e-05	7	46	2	32901017
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	4.77e-05	8	46	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	4.77e-05	8	46	2	31201465
Pubmed	Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.	BRCA1 JAG1	4.77e-05	8	46	2	18563556
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	4.77e-05	8	46	2	18339631
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	6.12e-05	9	46	2	38844137
Pubmed	IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.	STAT3 PRDM1	7.65e-05	10	46	2	32130409
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	7.65e-05	10	46	2	30738849
Pubmed	Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.	LRP2 JAG1	7.65e-05	10	46	2	30046000
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	NFYC NCOA1 NFAT5 LCORL ZNF644 STAT3 PRDM1	8.66e-05	808	46	7	20412781
Pubmed	Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.	LRP2 JAG1	9.34e-05	11	46	2	22999937
Pubmed	SorCS2 binds progranulin to regulate motor neuron development.	SORCS2 NEFH	9.34e-05	11	46	2	37897724
Pubmed	Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.	GPLD1 ABCB11 CD276	1.02e-04	68	46	3	22001757
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	1.12e-04	12	46	2	36779913
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 FBN2	1.12e-04	12	46	2	26405179
Pubmed	Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.	STAT3 PRDM1	1.12e-04	12	46	2	30759395
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP2 FBN1 FBN2	1.16e-04	71	46	3	33541421
Interaction	MFAP2 interactions	FBN1 FBN2 JAG1	1.70e-06	12	41	3	int:MFAP2
Interaction	FBN2 interactions	DUSP10 FBN1 FBN2 PRDM1	9.12e-06	65	41	4	int:FBN2
Interaction	NTN5 interactions	LRP2 FBN1 FBN2	1.54e-05	24	41	3	int:NTN5
Interaction	THRB interactions	NCOA1 NEFH FBN2 LCORL BTG1	3.63e-05	186	41	5	int:THRB
Interaction	SP1 interactions	NFYC LRP2 FBN1 FBN2 BRCA1 STAT3	8.92e-05	365	41	6	int:SP1
Interaction	POU6F1 interactions	NFYC STAT3	1.12e-04	8	41	2	int:POU6F1
Interaction	FHL2 interactions	NFYC DUSP10 BRCA1 NFAT5 STAT3 BORA	1.39e-04	396	41	6	int:FHL2
Interaction	STAT5A interactions	NCOA1 BRCA1 FARS2 STAT3	1.43e-04	131	41	4	int:STAT5A
Interaction	PARP16 interactions	NPC1 MDN1 ZNF644	1.43e-04	50	41	3	int:PARP16
Interaction	PNKD interactions	NPC1 GON4L PRMT9 IPO8	1.48e-04	132	41	4	int:PNKD
Interaction	MFAP5 interactions	FBN1 FBN2 JAG1	1.61e-04	52	41	3	int:MFAP5
Interaction	FBXO2 interactions	NPC1 LRP2 FBN1 FBN2 JAG1 CD276	1.70e-04	411	41	6	int:FBXO2
Cytoband	6q21	TUBE1 PRDM1	4.22e-03	96	46	2	6q21
Cytoband	1q44	OR2T3 OR2T34	5.50e-03	110	46	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr5q23	FBN2 DMXL1	6.19e-03	117	46	2	chr5q23
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	TUBE1 PRDM1	6.61e-03	121	46	2	chr6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr15q24	SCAMP5 CD276	6.72e-03	122	46	2	chr15q24
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T3 OR2T34	7.37e-03	128	46	2	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr4q31	PRMT9 FHDC1	1.18e-02	164	46	2	chr4q31
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 IGSF10 C2 FBN1 JAG1	1.77e-06	196	46	5	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 IGSF10 C2 FBN1 JAG1	1.77e-06	196	46	5	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	DUSP10 STAT3 BTG1 PRDM1	2.08e-05	157	46	4	f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF10 GPLD1 C2 SCAMP5	2.71e-05	168	46	4	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	droplet-Kidney-nan-3m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 LRP2 SLC9A8 AADAT	2.84e-05	170	46	4	dd48fd3c5c67eb71183981f42975a538f12077c3
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 DUSP10 BRCA1 BTG1	3.04e-05	173	46	4	de124fb7ded04664d4184bf12f1f201c0784f07c
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGSF10 GPLD1 C2 FBN1	3.55e-05	180	46	4	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 BRCA1 LCORL PUS7	3.62e-05	181	46	4	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 BRCA1 LCORL PUS7	3.62e-05	181	46	4	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 BRCA1 LCORL PUS7	3.62e-05	181	46	4	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DUSP10 FBN1 FBN2 LCORL	3.95e-05	185	46	4	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 IGSF10 FBN1 FBN2	4.03e-05	186	46	4	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 IGSF10 FBN1 FBN2	4.11e-05	187	46	4	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 IGSF10 FBN1 FBN2	4.11e-05	187	46	4	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 IGSF10 FBN1 FBN2	4.11e-05	187	46	4	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	normal-na-Hematopoietic-progenitor_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LRP2 IGSF10 FBN1 AADAT	4.20e-05	188	46	4	013162466a3334b6967c0cb670c8577d809b1396
ToppCell	normal-na-Hematopoietic-progenitor_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LRP2 IGSF10 FBN1 AADAT	4.20e-05	188	46	4	be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell	ILEUM-inflamed-(1)_Tregs\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DUSP10 STAT3 BTG1 PRDM1	4.56e-05	192	46	4	1fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPC1 SORCS2 GPLD1 FHDC1	4.75e-05	194	46	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	ASK440-Epithelial-Type_2\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	NPC1 C2 FHDC1 BTG1	5.04e-05	197	46	4	08d5bbeb77a4152af1c783bc958afcae24667767
ToppCell	BAL-Control-cDC_5\|Control / Compartment, Disease Groups and Clusters	DUSP10 STAT3 BTG1 PRDM1	5.04e-05	197	46	4	8a3fe59be3ed1f0254cc8c60b99c840193370efb
ToppCell	Non-neuronal-Dividing-IPC-IPC-new\|World / Primary Cells by Cluster	DUSP10 BRCA1 BTG1 JAG1	5.14e-05	198	46	4	11d2d4d179bc31ef2897d7ceeaf9bed1b20cbdc0
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPC1 SORCS2 LRP2 FHDC1	5.14e-05	198	46	4	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	NPC1 DUSP10 TSPOAP1 PRDM1	5.14e-05	198	46	4	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	Non-neuronal-Dividing-IPC-IPC-new-9\|World / Primary Cells by Cluster	DUSP10 BRCA1 BTG1 JAG1	5.14e-05	198	46	4	c724ef958e14e17a7d8c02b9f842510c0780f635
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DUSP10 STAT3 BTG1 PRDM1	5.14e-05	198	46	4	d021d0edb6aba2f15c51a3ec4e08c7233d0c1962
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPC1 LRP2 C2 FHDC1	5.24e-05	199	46	4	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SORCS2 IGSF10 DUSP10	3.73e-04	136	46	3	8f5682422ba0b477c1e0700212948457f106cb10
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_-_proliferative\|E16.5-samps / Age Group, Lineage, Cell class and subclass	C2 TUBE1 LCORL	3.73e-04	136	46	3	96370f0e3abf1c9ec7a91595b5d0f97ac2ab4b78
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SORCS2 IGSF10 FBN2	3.81e-04	137	46	3	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 ABCB11 AADAT	3.97e-04	139	46	3	82bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCell	facs-Liver-Hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 ABCB11 AADAT	3.97e-04	139	46	3	fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 ABCB11 AADAT	3.97e-04	139	46	3	4ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 ABCB11 AADAT	3.97e-04	139	46	3	fc9ac09c2106e88104a52575832d71d17765eec8
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tfh\|Lung / Manually curated celltypes from each tissue	LRP2 BTG1 PRDM1	4.23e-04	142	46	3	319812c84fad93276bf093f2ad78db02ae745bf4
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SORCS2 IGSF10 DUSP10	4.87e-04	149	46	3	5293c50b3fb41b1edaf9a97354899bd13770078c
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNHD1 TSPOAP1 PRDM1	5.06e-04	151	46	3	7270b8bbfae659e110bd9d513b602120b25de3dd
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 SCAMP5 PRDM1	5.26e-04	153	46	3	e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 SCAMP5 PRDM1	5.26e-04	153	46	3	668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 SCAMP5 PRDM1	5.26e-04	153	46	3	4b999892fb797e9f0d391630094f466463299d57
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 C2 JAG1	5.26e-04	153	46	3	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	LRP2 FBN2 BRCA1	5.56e-04	156	46	3	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRMT9 PUS7 BORA	5.77e-04	158	46	3	91d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 KLF18 FBN2	5.99e-04	160	46	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 KLF18 FBN2	5.99e-04	160	46	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Marrow-T-cells-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 MBD5 PUS7	5.99e-04	160	46	3	b3f7ef7e682b48a83ca425f5c439336e96168300
ToppCell	COVID-CD8-memory_CD4\|COVID / Condition, Cell_class and T cell subcluster	NCOA1 KIF3B BORA	6.21e-04	162	46	3	22b2a32217d357146c117e618813d451510a1801
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRMT9 AADAT PRDM1	6.32e-04	163	46	3	4dfd408aa700e307478ee35f6b902f68719d8d9e
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh\|GI_large-bowel / Manually curated celltypes from each tissue	PRMT9 STAT3 JAG1	6.32e-04	163	46	3	4104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NPC1 C2 FHDC1	6.43e-04	164	46	3	b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell	BAL-Severe-cDC_8\|Severe / Compartment, Disease Groups and Clusters	SORCS2 PRMT9 PRDM1	6.43e-04	164	46	3	e8cbe7e01eca32886eb44e02d5333056b6bebc50
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	LRP2 C2 FHDC1	6.43e-04	164	46	3	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NPC1 C2 FHDC1	6.43e-04	164	46	3	3aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	LRP2 C2 FHDC1	6.43e-04	164	46	3	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	normal_Lymph_Node-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	NEFH DUSP10 BTG1	6.66e-04	166	46	3	d638d356592325cded4a6cb549041cf2f8d3e62c
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LRP2 NEFH BORA	6.66e-04	166	46	3	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	normal_Lung-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	PRMT9 BTG1 PRDM1	6.66e-04	166	46	3	07b498eb341abec02a3ccaae320bdbb5cd6883c5
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	AADAT BRCA1 SOWAHD	6.66e-04	166	46	3	20f248d95c86eb52a1efe9abe73123fbe4206caf
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-2_PVALB_TAC1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IGSF10 FBN2 PRDM1	6.78e-04	167	46	3	d5b62934b3533d65e552adfc99a65d29f874cbb0
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	6.78e-04	167	46	3	ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 SLC9A8 AADAT	6.78e-04	167	46	3	40d102e01ccbc7262d00fafd59ca5234909009cb
ToppCell	droplet-Fat-Bat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF3B TSPOAP1 PRDM1	6.90e-04	168	46	3	6fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCell	droplet-Fat-Bat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF3B TSPOAP1 PRDM1	6.90e-04	168	46	3	794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCell	COVID-19-Myeloid-MoAM5,_CCL3L1\|Myeloid / Condition, Lineage and Cell class	IQCJ-SCHIP1 DUSP10 NFAT5	6.90e-04	168	46	3	ea465152ea31391b63c02425beafa9a4f51f6703
ToppCell	droplet-Fat-Bat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF3B TSPOAP1 PRDM1	6.90e-04	168	46	3	1e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	7.02e-04	169	46	3	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUBE1 LCORL BORA	7.02e-04	169	46	3	f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_SCN7A\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 NEFH	7.14e-04	170	46	3	a0047551619547971d55165156f61f090948f902
ToppCell	droplet-Kidney-nan-21m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	7.26e-04	171	46	3	007f148f4611ea1826edfa9f91ced36541ad9f5a
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP10 BRCA1 TUBE1	7.26e-04	171	46	3	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	7.26e-04	171	46	3	8e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	BTG1 SOWAHD PRDM1	7.26e-04	171	46	3	bdd30100b74e012eec3090799c22635aa57fa91d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCB11 BTG1 JAG1	7.39e-04	172	46	3	965a9f62b73a7e3531c343121a7c507b7e1bfe05
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHDC1 TUBE1 JAG1	7.51e-04	173	46	3	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GON4L DUSP10 KIF3B	7.51e-04	173	46	3	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GON4L DUSP10 KIF3B	7.51e-04	173	46	3	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 SOWAHD BORA	7.64e-04	174	46	3	e5f12831187140e84b9a49e93b2376b9fefb1aec
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP2 C2 SCAMP5	7.64e-04	174	46	3	4da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	NEFH BORA CD276	7.76e-04	175	46	3	d3890bd0c570bb81434fdd1c5229891cefe2e462
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPLD1 PRMT9 MBD5	7.76e-04	175	46	3	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 FBN1 BORA	7.76e-04	175	46	3	a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	7.76e-04	175	46	3	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPLD1 PRMT9 MBD5	7.76e-04	175	46	3	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	7.76e-04	175	46	3	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 SOWAHD BORA	7.89e-04	176	46	3	bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	DUSP10 TUBE1 DMXL1	7.89e-04	176	46	3	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRMT9 BTG1 PRDM1	7.89e-04	176	46	3	b99e20e4dd8b3322c9d7a08d518ed4f8f356b3de
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRMT9 NFAT5 PRDM1	8.02e-04	177	46	3	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 NEFH	8.02e-04	177	46	3	a25ca82c4bda033ee113f8ecb4a541b22e7a29ca
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 SLC9A8 AADAT	8.02e-04	177	46	3	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 NEFH	8.02e-04	177	46	3	fbead6e56271b1f1d447f89857de444ebe7157b0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_MORN2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 NEFH	8.16e-04	178	46	3	b0fc56f583cb3f2977fe2306994c0d478c9a6b1b
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BRCA1 LCORL PUS7	8.16e-04	178	46	3	b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEFH FBN2 SOWAHD	8.29e-04	179	46	3	61dbfc1b9b0344c06a68142c181cd62993556a67
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 FBN1 AADAT	8.29e-04	179	46	3	2f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	IGSF10 FBN1 AADAT	8.29e-04	179	46	3	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 FBN1 AADAT	8.29e-04	179	46	3	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 FBN1 AADAT	8.29e-04	179	46	3	3e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCell	droplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRP2 FHDC1 TUBE1	8.29e-04	179	46	3	ca70a5518c5a5392e088c103e0cb44aa084f5332
ToppCell	droplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRP2 FHDC1 TUBE1	8.29e-04	179	46	3	c451b074b04eb5d6c575c6abaedda579c6744bbf
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	6.22e-06	3	43	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	1.24e-05	4	43	2	DOID:0060249 (is_implicated_in)
Disease	systemic lupus erythematosus	SORCS2 C2 IQCJ-SCHIP1 FBN2 SCAMP5 PUS7 STAT3 PRDM1	1.75e-05	799	43	8	MONDO_0007915
Disease	nasal type extranodal NK/T-cell lymphoma (is_marker_for)	STAT3 PRDM1	2.07e-05	5	43	2	DOID:0080797 (is_marker_for)
Disease	pulse pressure measurement	NPC1 ABCB11 IQCJ-SCHIP1 FBN1 FBN2 MBD5 NFAT5 LCORL STAT3 JAG1	2.43e-05	1392	43	10	EFO_0005763
Disease	Familial thoracic aortic aneurysm and aortic dissection	FBN1 FBN2 JAG1	6.42e-05	53	43	3	C4707243
Disease	non-high density lipoprotein cholesterol measurement	NPC1 SORCS2 ABCB11 C2 LCORL STAT3 PRDM1	7.06e-05	713	43	7	EFO_0005689
Disease	manic episode measurement, depressive episode measurement	SORCS2 NFYC	7.42e-05	9	43	2	EFO_0007704, EFO_0007705
Disease	monocyte percentage of leukocytes	NPC1 NCOA1 KIF3B IPO8 BRCA1 MBD5 TSPOAP1	8.25e-05	731	43	7	EFO_0007989
Disease	Abnormal behavior	SCAMP5 PUS7	2.46e-04	16	43	2	C0233514
Disease	coronary artery disease	NPC1 IGSF10 C2 SLC9A8 FBN2 NFAT5 LCORL DMXL1	2.88e-04	1194	43	8	EFO_0001645
Disease	Intellectual Disability	LRP2 GON4L BRCA1 SCAMP5 PUS7	4.67e-04	447	43	5	C3714756
Disease	blood urea nitrogen measurement	LRP2 GON4L MBD5 NFAT5 LCORL	4.92e-04	452	43	5	EFO_0004741
Disease	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis	SLC9A8 KIF3B STAT3 PRDM1	8.89e-04	295	43	4	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Disease	hyperuricemia	LRP2 NFAT5	1.06e-03	33	43	2	EFO_0009104
Disease	ascending aortic diameter	FBN1 FBN2 MBD5	1.12e-03	140	43	3	EFO_0021787
Disease	psoriasis (is_implicated_in)	C2 STAT3	1.13e-03	34	43	2	DOID:8893 (is_implicated_in)
Disease	cataract	NFAT5 LCORL JAG1	1.15e-03	141	43	3	MONDO_0005129
Disease	eosinophil count	GPLD1 SLC9A8 IQCJ-SCHIP1 KIF3B MDN1 BRCA1 MBD5 JAG1	1.23e-03	1488	43	8	EFO_0004842
Disease	response to sulfasalazine, Drug-induced agranulocytosis	C2 TSPOAP1	1.34e-03	37	43	2	EFO_0008324, HP_0012235

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGQMDLCVTSGSQQG	AADAT	106	Q8N5Z0
CQNEMSSGTGQSNTV	PRMT9	561	Q6P2P2
NSSLNQNMTNGTRCG	ABCB11	116	O95342
LTGNVTTSQMANEQG	CD276	186	Q5ZPR3
AAGQCNNMGQKRQTE	DNHD1	2061	Q96M86
GNIQVGCVDCSMQQG	DMXL1	56	Q9Y485
QGARAQQAPNTEMCQ	TSPOAP1	1206	O95153
QFNLQGSQGMEETSQ	FHDC1	681	Q9C0D6
ASCGQTGVENMQNTQ	MDN1	5031	Q9NU22
TICGVGNMSANASDQ	C2	461	P06681
TVNRMQEQNTQQGDG	LCORL	216	Q8N3X6
TCPANQMVNNNENTG	DUSP10	111	Q9Y6W6
QLPGMQCQQQSVCSQ	PGLYRP3	51	Q96LB9
AESSNGCSNNMNACQ	LRP2	2016	P98164
MCSGNQTSQNQTAST	OR2T34	1	Q8NGX1
MCSGNQTSQNQTAST	OR2T3	1	Q8NH03
MSVQNSGTQQQGNGL	NFAT5	1031	O94916
QAQQAQSGTGQTMQV	NFYC	211	Q13952
GMGCNNDSLVQQIFN	NPC1	911	O15118
QGSGAAQAQMQAETR	NEFH	246	P12036
MINQGTNQTEQNGQV	BRCA1	531	P38398
TDQSGNEANMVCSIQ	IGSF10	321	Q6WRI0
SNQMCQGQLSGIVCT	FBN1	191	P35555
TQNCGSNIMDTVGAE	BORA	501	Q6PGQ7
TMCQEQGAQPQTFNI	GON4L	2166	Q3T8J9
QIQASGNCGMLSQSG	MBD5	786	Q9P267
QTLCGEQMTTSSGNQ	KLF18	231	A0A0U1RQI7
QMTTSTGNQTLCGEQ	KLF18	251	A0A0U1RQI7
QTLCGEQVMTSTGNQ	KLF18	301	A0A0U1RQI7
ALCGGQMTTSTGNQN	KLF18	316	A0A0U1RQI7
NQNLCGEQVMTSTGN	KLF18	356	A0A0U1RQI7
QALCGGQMTTSTGNQ	KLF18	371	A0A0U1RQI7
GNQNLCGEQVMTSTG	KLF18	411	A0A0U1RQI7
NQALCGGQMTTSTGN	KLF18	426	A0A0U1RQI7
TSTGNQNLCGEQVMT	KLF18	436	A0A0U1RQI7
QNLCGEQVMTSTSNQ	KLF18	441	A0A0U1RQI7
TSTGNQNLCGEQMTT	KLF18	506	A0A0U1RQI7
QNLCGEQMTTSTGNQ	KLF18	511	A0A0U1RQI7
TGNQNLCGEQMTTST	KLF18	746	A0A0U1RQI7
CQSESTQQMGFVAQS	KRTAP27-1	116	Q3LI81
NNQMCQGQLTGIVCT	FBN2	221	P35556
QQAAQNAAMGAAQGA	SCAMP5	201	Q8TAC9
SMQNVNGELQNGNCC	JAG1	41	P78504
EETNVTAQAMQSNNG	IPO8	906	O15397
SITVSMAGGNTNVQN	NCOA1	1316	Q15788
VSNVCEGGVDMQQSQ	SORCS2	756	Q96PQ0
EGGVDMQQSQVQLQC	SORCS2	761	Q96PQ0
NITGTDDQVQQAMNS	PUS7	351	Q96PZ0
QTGEQAQQEEQSSGM	SLC9A8	46	Q9Y2E8
NCNGLSAVSSMNGIN	PRDM1	421	O75626
EMESGSGCTNLNNNS	SOWAHD	246	A6NJG2
QSGMNLQICFVNDSG	IQCJ-SCHIP1	371	B3KU38
GGSTQNSTNVQMVDS	BTG1	131	P62324
MTQSVVVQVGQCGNQ	TUBE1	1	Q9UJT0
VGNQNRSVGATNMNE	KIF3B	196	O15066
SQGDMQDLNGNNQSV	STAT3	181	P40763
ACGGQQNHTQGSKMQ	GPLD1	286	P80108
IAQSGVNMCNQNSSP	ZNF644	691	Q9H582
CGVMEQQLVNSAGAQ	FARS2	291	O95363