Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

2.18e-0767971143.30.160.60
DomainZnf_C2H2-like

ZNF729 KAT7 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

2.40e-077967115IPR015880
DomainZnf_C2H2

ZNF729 KAT7 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

2.77e-078057115IPR007087
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

2.84e-076947114IPR013087
DomainZnF_C2H2

ZNF729 KAT7 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

2.91e-078087115SM00355
DomainZINC_FINGER_C2H2_2

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

1.07e-067757114PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

1.10e-067777114PS00028
Domainzf-C2H2

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

1.80e-066937113PF00096
DomainBTB

ZBTB44 ZBTB21 ZBTB18 ZBTB1

1.56e-03131714PF00651
DomainUBA-like

LATS2 ASCC2 HUWE1

1.86e-0364713IPR009060
DomainKRAB

ZNF729 ZNF676 ZIK1 ZNF268 ZNF350 ZNF649

2.39e-03358716PS50805
DomainKRAB

ZNF729 ZNF676 ZIK1 ZNF268 ZNF350 ZNF649

2.78e-03369716SM00349
DomainKRAB

ZNF729 ZNF676 ZIK1 ZNF268 ZNF350 ZNF649

2.81e-03370716IPR001909
DomainBTB

ZBTB44 ZBTB21 ZBTB18 ZBTB1

3.23e-03160714PS50097
Pubmed

BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.

KAT7 HUWE1

4.35e-06273232555450
Pubmed

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

ZBTB44 ZBTB21 ZBTB18 ZBTB1

9.69e-066373434351428
Pubmed

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.

DCAF1 LATS2

4.33e-05573228068668
Pubmed

EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

DCAF1 RORA

4.33e-05573223063525
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

DLGAP1 CTCFL SNRNP48 GPC5 CSMD1 UNC13A TRAPPC9 KMO ARPC2

5.14e-0581473923251661
Pubmed

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.

ZBTB21 ZBTB1

9.06e-05773220797634
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLII ZNF276 LATS2 ZFYVE26 FGFR1 HUWE1 PRDM16 TRAPPC9 TIAM2 PHC2

1.02e-041105731035748872
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

FLII TFB1M ASAP3 ASCC2 WDR48

1.09e-0422373533187986
Pubmed

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.

DCAF1 LATS2

1.21e-04873225026211
Pubmed

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

ZNF268 ZNF350

1.55e-04973223665872
Pubmed

FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion.

FGFR1 ITGA1

1.93e-041073236861436
Pubmed

NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.

DCAF1 HUWE1

1.93e-041073233058421
Pubmed

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans.

MIR17HG GPC5

1.93e-041073221892160
Pubmed

Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain.

FGFR1 GPC5

1.93e-041073217107664
Pubmed

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

LATS2 TLR7

2.36e-041173227912060
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

DCAF1 FLII DLGAP1 HUWE1 TIAM2

2.74e-0427273518187620
Pubmed

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.

GPC5 CSMD1

2.83e-041273220944657
Pubmed

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.

WRN WDR48

5.79e-041773236352191
Pubmed

CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.

DCAF1 HUWE1

6.51e-041873229507117
Pubmed

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.

CTCFL WRN

7.26e-041973214578343
Pubmed

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.

FAM222A RORA

8.06e-042073234127677
Pubmed

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

KAT7 JADE3

8.89e-042173227270040
Pubmed

Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.

DCAF1 HUWE1

1.07e-032373222038470
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FLII JADE3 ZBTB21 HELZ PLCB3 HUWE1 PHC2

1.20e-0377473715302935
Pubmed

Centrosome-related genes, genetic variation, and risk of breast cancer.

PLK2 LATS2 WRN

1.31e-0310273320508983
Pubmed

Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation.

FGFR1 PRDM16

1.37e-032673230352954
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

PLCB3 SNTB1

1.47e-032773218468998
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

DCAF1 KAT7 CHERP HUWE1 PHC2

1.49e-0339673526687479
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

FLII DLGAP1 UNC13A ARPC2

1.49e-0323373429518331
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

DCAF1 WRN ZBTB21 ASCC2 HELZ GCNT1 CSMD1 KMO TIAM2

1.51e-03129373915342556
Pubmed

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

JADE3 ASCC2

1.82e-033073230480076
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

GPC5 TRAPPC9

2.07e-033273225189868
Pubmed

Genome-wide association study of lung function decline in adults with and without asthma.

RORA CSMD1

2.07e-033273222424883
Cytoband1q44

OR2L2 OR2L5 ZBTB18

7.37e-041107331q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2L2 OR2L5 ZBTB18

1.14e-03128733chr1q44
Cytoband8p12

WRN FGFR1

2.57e-03477328p12
CytobandXq13.1

OTUD6A AWAT1

2.68e-0348732Xq13.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZBTB44 CTCFL ZNF676 ZNF276 ZIK1 ZNF268 ZBTB21 YY2 ZNF350 ZNF649 ZBTB18 PRDM16 ZBTB1

5.41e-08718591428
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB44 ZBTB21 ZBTB18 ZBTB1

9.58e-04134594861
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF1 DTL

1.55e-0318592498
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN

KAT7 LATS2 ZBTB21 ZNF350 FGFR1 ZBTB1 WDR48

1.20e-05276737M41128
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000_k-means-cluster#5

MYO1G CTCFL ADAMTS2 EML6 ASAP3 ITGA1

4.86e-05207676Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000_K5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_1000

ZBTB44 ZIK1 TFB1M ADAMTS2 JADE3 WRN ZBTB21 ITGA1 GCNT1 HUWE1 ZBTB1

5.07e-058266711DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_1000
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

MYO1G ZIK1 ZNF350 ZBTB18 DNAH1

2.68e-061337358ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP3 TLR7 GCNT1 KMO CHST3

9.92e-061747352f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP3 TLR7 GCNT1 KMO CHST3

9.92e-0617473501eff218e71a04201189a0313aaf91437fffed95
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP3 TLR7 GCNT1 KMO CHST3

9.92e-06174735f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLK2 FGFR1 ITGA1 PCDH12 PHC2

1.17e-05180735493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 RASGRP3 PCDH12 TNS3 CHST3

1.23e-05182735b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DLGAP1 CTCFL ITGA1 CSMD1 SNTB1

1.44e-05188735502045a39ffb1e92bd9499848368e8fa971edb88
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

DLGAP1 TFB1M WRN HELZ SNTB1

1.59e-05192735916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

DLGAP1 TFB1M WRN HELZ SNTB1

1.63e-05193735e6a688bc834f845ff64dae1be64f073eec5091a1
Diseasealpha wave measurement, electroencephalogram measurement

TFB1M TNS3 DNAH1

1.21e-0610653EFO_0004357, EFO_0006870
Diseasetelomere length

ZNF729 ZNF676 ADAMTS2 ASCC2 CSMD1 SNTB1

6.63e-05313656EFO_0004505
Diseasesmoking status measurement, triglyceride measurement

ZNF729 ZNF676

7.13e-056652EFO_0004530, EFO_0006527
Diseaseglypican-5 measurement

MIR17HG GPC5

1.33e-048652EFO_0008139
DiseaseAstigmatism

MYO1G ADAMTS2 EML6 GPC5

1.92e-04129654HP_0000483
Diseasesex interaction measurement, longitudinal BMI measurement

WRN GPC5

2.13e-0410652EFO_0005937, EFO_0008343
Diseasealpha angle measurement

TFB1M TIAM2

2.59e-0411652EFO_0020071
Diseasetriacylglycerol 52:1 measurement

RORA CSMD1

4.27e-0414652EFO_0010413
Diseaseschizophrenia (implicated_via_orthology)

CSMD1 KMO CHST3

4.62e-0468653DOID:5419 (implicated_via_orthology)
Diseasetotal blood protein measurement

KAT7 RASGRP3 RORA FGFR1 ITGA1 DNAH1

4.65e-04449656EFO_0004536
DiseaseEczema

DLGAP1 RORA FGFR1 PRDM16 ZBTB1

6.11e-04310655HP_0000964
Diseaseexercise test

CCDC60 WRN

8.85e-0420652EFO_0004328
Diseasephysical activity

CTCFL GPC5 CSMD1

9.80e-0488653EFO_0003940
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

DEFB133 PLK2 PLCB3 DNAH1

1.00e-03200654EFO_0004611, EFO_0020945
DiseaseCerebral Astrocytoma

LATS2 FGFR1

1.39e-0325652C0750935
DiseaseIntracranial Astrocytoma

LATS2 FGFR1

1.39e-0325652C0750936
DiseasePilocytic Astrocytoma

LATS2 FGFR1

1.39e-0325652C0334583
DiseaseAstrocytoma

LATS2 FGFR1

1.39e-0325652C0004114
DiseaseJuvenile Pilocytic Astrocytoma

LATS2 FGFR1

1.39e-0325652C0280783
DiseaseDiffuse Astrocytoma

LATS2 FGFR1

1.39e-0325652C0280785
DiseaseGrade I Astrocytoma

LATS2 FGFR1

1.39e-0325652C1704230
DiseaseSubependymal Giant Cell Astrocytoma

LATS2 FGFR1

1.39e-0325652C0205768
DiseaseMixed oligoastrocytoma

LATS2 FGFR1

1.39e-0325652C0547065
DiseaseChildhood Cerebral Astrocytoma

LATS2 FGFR1

1.39e-0325652C0338070
Diseasewaist-hip ratio

CTCFL TFB1M ADAMTS2 ZNF268 RORA PLCB3 FGFR1 PRDM16 SNTB1

1.41e-031226659EFO_0004343
DiseaseAdenoid Cystic Carcinoma

WNT5B MYCBP DTL

1.42e-03100653C0010606
DiseaseFEV/FEC ratio

KAT7 ADAMTS2 RASGRP3 ASCC2 FGFR1 GPC5 ITGA1 CSMD1 PRDM16

1.43e-031228659EFO_0004713
DiseaseGemistocytic astrocytoma

LATS2 FGFR1

1.50e-0326652C0334581
DiseaseProtoplasmic astrocytoma

LATS2 FGFR1

1.50e-0326652C0334580
DiseaseFibrillary Astrocytoma

LATS2 FGFR1

1.50e-0326652C0334582
Diseasenicotine withdrawal measurement

CSMD1 TIAM2

1.62e-0327652EFO_0009362
DiseaseAnaplastic astrocytoma

LATS2 FGFR1

1.62e-0327652C0334579
Diseaselumbar disc degeneration

CSMD1 CHST3

1.74e-0328652EFO_0004994
Diseasereticulocyte count

MYO1G PLK2 EML6 ASCC2 RORA PLCB3 ITGA1 TNS3

2.04e-031045658EFO_0007986
Diseasetriacylglycerol 50:2 measurement

RORA CSMD1

2.13e-0331652EFO_0010409

Protein segments in the cluster

PeptideGeneStartEntry
RLCKSADYMNLHFKV

UNC13A

1106

Q9UPW8
MSFEYRHYKREAKIC

nan

1

A8MUN3
RKCEAVASAMHSSRY

FAM222A

26

Q5U5X8
IMAKYVEHRFARRCT

ASAP3

531

Q8TDY4
FKTKSLLRFSCEMGH

CSMD1

2936

Q96PZ7
MCKYASVEASKLKRH

CTCFL

346

Q8NI51
ARRMAFLAKKGYRHD

ASCC2

691

Q9H1I8
KCSKAYIHTRMRAKT

ARPC2

256

O15144
YTRMVLEFKCKHSKS

GSG1

256

Q2KHT4
CFRMRSHSYVRAIEK

DLGAP1

486

O14490
MRKICTYFHRKSQED

DTL

706

Q9NZJ0
KRMVHDGTRCSYKDA

ADAMTS2

671

O95450
FTKYGCRRRLDHKMV

ADAMTS2

876

O95450
IHYKSGVCNTMRAKF

CCDC60

376

Q8IWA6
RMHSAEGRKKAYSTC

OR2L2

226

Q8NH16
FMSICRTEKKDNRAY

PCDH12

736

Q9NPG4
RCRTASYMKKHVDEF

OTUD6A

171

Q7L8S5
TGKHTCMALRKYFEA

DCAF1

516

Q9Y4B6
CMALRKYFEAHLAIK

DCAF1

521

Q9Y4B6
KRRRFHESYNFNMKC

KAT7

171

O95251
MKHTRLFRCSNEKGY

FLII

1161

Q13045
CKVDTHALYAMKTLR

LATS2

686

Q9NRM7
YLHFSKECSRALLKM

GPC5

241

P78333
MFCHVDVKISSKRYT

MIR17HG

1

Q75NE6
RMHSAEGRKKAYSTC

OR2L5

226

Q8NG80
DRFINSKCAKYMLRA

NAA16

441

Q6N069
MAHYKAADSKREQFR

MYCBP

1

Q99417
VRKSECTKHSFYMLD

ITGA1

751

P56199
SLKRQDYEMALKHCT

HELZ

16

P42694
LCLRLTRDHKYAMMF

HUWE1

1781

Q7Z6Z7
EAARKRNKCFEMSSF

PLCB3

606

Q01970
SNVCRSLFEKHKLMF

DNAH1

3511

Q9P2D7
CDGAYSTVRSHLMKK

KMO

166

O15229
ERRHVSDLKFAMKCY

GNPAT

41

O15228
KSYSFIARMKARDEC

CHERP

901

Q8IWX8
MEYLASKKCIHRDLA

FGFR1

611

P11362
FHKDSRMYKFQSCFR

AWAT1

231

Q58HT5
MFERCLKTYAIKRSA

EML6

931

Q6ZMW3
KDTYSCFIMRGKCRH

DEFB133

26

Q30KQ1
MTSDCSSFIKRRKYI

GCNT1

96

Q02742
YSHKMVKTNHRRCRT

DUXA

6

A6NLW8
CYMISRREKLKLSHN

JADE3

486

Q92613
SFHRDRKSIPLKMCY

SNTB1

236

Q13884
AYFLRAKSQLHCKMG

RASGRP3

476

Q8IV61
KSYTQFSNLCRHKRM

PRDM16

401

Q9HAZ2
SISHFKSLCDVYRKM

TFB1M

296

Q8WVM0
MAKMEKYLHSSRCRR

WRN

896

Q14191
CHEAAVSIYCSMRKR

SLC38A8

231

A6NNN8
MVKCYHKKYRSATRD

TNS3

241

Q68CZ2
CRDFVHSLKMRSKYA

CHST3

11

Q7LGC8
TFCENKHYLMCERKA

CLEC1B

206

Q9P126
MDNKRCDRHYKKSFF

PRSS45P

146

Q7RTY3
AYKFKRSKRFCSMAC

PHC2

651

Q8IXK0
RSKRFCSMACAKRYN

PHC2

656

Q8IXK0
IFSFSRKCHYASRML

TMEM269

51

A0A1B0GVZ9
RKCHYASRMLLVSFL

TMEM269

56

A0A1B0GVZ9
RQFMCKLCHRTFKTA

ZBTB21

1041

Q9ULJ3
LKCKEYVRSFCMLSH

ZNF676

141

Q8N7Q3
KGFCMSTLRTHKDYV

WDR48

106

Q8TAF3
CGKAFRSKSYLIIHM

ZNF268

701

Q14587
KFHMDLFRMRCYLAS

TIAM2

686

Q8IVF5
CGRHTEKLMAFKAIY

RORA

481

P35398
GKTFSCMYTLKRHER

ZBTB18

416

Q99592
KRDMDRASYVKCCLF

ZIK1

146

Q3SY52
CEKMFRDYAAMRKHL

YY2

261

O15391
RCGKKFTRAYSLKMH

ZBTB44

431

Q8NCP5
FQCRQRASLKYHMTK

ZNF276

531

Q8N554
RRAVYKMADVACKCH

WNT5B

206

Q9H1J7
YARSCRFKNKEASFM

TLR7

471

Q9NYK1
CGAKFNLRKDMRSHY

ZBTB1

691

Q9Y2K1
FAYMSCLVKHKRIHT

ZNF350

411

Q9GZX5
HRKSAFFKRVAAMQC

TRAPPC9

401

Q96Q05
YCSRRSMAHILKARK

PLK2

161

Q9NYY3
RAAMTCIRFFSHKAK

ZFYVE26

2266

Q68DK2
LAKHMASCRLRKMGY

SNRNP48

71

Q6IEG0
SKSFFMLSCLIRHKR

ZNF729

186

A6NN14
YMSCLVKHKRIHSRE

ZNF649

441

Q9BS31
YKAMKHRSRDTCIVI

MYO1G

86

B0I1T2