Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-lactate dehydrogenase activity	LDHB LDHC	7.41e-05	5	55	2	GO:0004459
GeneOntologyMolecularFunction	methylation-dependent protein binding	L3MBTL1 PHF20L1 CHD1 L3MBTL3	1.01e-04	88	55	4	GO:0140034
GeneOntologyMolecularFunction	lactate dehydrogenase activity	LDHB LDHC	1.11e-04	6	55	2	GO:0004457
Domain	MBT	L3MBTL1 PHF20L1 L3MBTL3	2.41e-06	10	52	3	PF02820
Domain	Mbt	L3MBTL1 PHF20L1 L3MBTL3	2.41e-06	10	52	3	IPR004092
Domain	L-lactate_DH	LDHB LDHC	7.56e-05	5	52	2	IPR011304
Domain	L-lactate_DH_AS	LDHB LDHC	7.56e-05	5	52	2	IPR018177
Domain	L_LDH	LDHB LDHC	7.56e-05	5	52	2	PS00064
Domain	ZF_CCHHC	L3MBTL1 L3MBTL3	1.58e-04	7	52	2	PS51802
Domain	SIX1_SD	SIX1 SIX2	1.58e-04	7	52	2	PF16878
Domain	SIX1_SD	SIX1 SIX2	1.58e-04	7	52	2	IPR031701
Domain	L-lactate/malate_DH	LDHB LDHC	2.11e-04	8	52	2	IPR001557
Domain	Ldh_1_N	LDHB LDHC	2.11e-04	8	52	2	PF00056
Domain	Lactate/malate_DH_N	LDHB LDHC	2.11e-04	8	52	2	IPR001236
Domain	-	LDHB LDHC	2.70e-04	9	52	2	3.90.110.10
Domain	Lactate/malate_DH_C	LDHB LDHC	2.70e-04	9	52	2	IPR022383
Domain	Lactate_DH/Glyco_Ohase_4_C	LDHB LDHC	2.70e-04	9	52	2	IPR015955
Domain	MBT	L3MBTL1 L3MBTL3	2.70e-04	9	52	2	SM00561
Domain	Ldh_1_C	LDHB LDHC	2.70e-04	9	52	2	PF02866
Domain	MBT	L3MBTL1 L3MBTL3	2.70e-04	9	52	2	PS51079
Domain	SAM_1	L3MBTL1 L3MBTL3 ANKS1A	8.98e-04	68	52	3	PF00536
Domain	SAM	L3MBTL1 L3MBTL3 ANKS1A	1.89e-03	88	52	3	SM00454
Domain	SAM_DOMAIN	L3MBTL1 L3MBTL3 ANKS1A	2.35e-03	95	52	3	PS50105
Domain	SAM	L3MBTL1 L3MBTL3 ANKS1A	2.50e-03	97	52	3	IPR001660
Domain	PID	SHC2 ANKS1A	2.74e-03	28	52	2	PF00640
Domain	-	L3MBTL1 L3MBTL3 ANKS1A	3.21e-03	106	52	3	1.10.150.50
Domain	SNF2_N	CHD1 BTAF1	3.57e-03	32	52	2	IPR000330
Domain	PID	SHC2 ANKS1A	3.57e-03	32	52	2	PS01179
Domain	SNF2_N	CHD1 BTAF1	3.57e-03	32	52	2	PF00176
Domain	SAM/pointed	L3MBTL1 L3MBTL3 ANKS1A	4.24e-03	117	52	3	IPR013761
Domain	PTB	SHC2 ANKS1A	5.54e-03	40	52	2	SM00462
Domain	PTB/PI_dom	SHC2 ANKS1A	5.82e-03	41	52	2	IPR006020
Domain	-	USP22 PHF20L1 BAZ1B TRIM36 RNF145	8.07e-03	449	52	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	USP22 PHF20L1 BAZ1B TRIM36 RNF145	8.83e-03	459	52	5	IPR013083
Pubmed	Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.	SIX1 SIX2	2.55e-06	2	56	2	33281191
Pubmed	Testis-specific lactate dehydrogenase (LDH-C4; Ldh3) in murine oocytes and preimplantation embryos.	LDHB LDHC	2.55e-06	2	56	2	16582413
Pubmed	Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.	LDHB LDHC	7.63e-06	3	56	2	34708888
Pubmed	Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.	LDHB LDHC	7.63e-06	3	56	2	17853776
Pubmed	Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.	SIX1 SIX2	7.63e-06	3	56	2	11734542
Pubmed	Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli.	LDHB LDHC	7.63e-06	3	56	2	1996957
Pubmed	Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis.	LDHB LDHC	7.63e-06	3	56	2	2401207
Pubmed	The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.	PRF1 STAT4	7.63e-06	3	56	2	12372421
Pubmed	Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?	LDHB LDHC	7.63e-06	3	56	2	17178662
Pubmed	Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.	SIX1 SIX2	7.63e-06	3	56	2	15735644
Pubmed	Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.	LDHB LDHC	7.63e-06	3	56	2	11276087
Pubmed	DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1.	PDE4D DISC1	7.63e-06	3	56	2	23587879
Pubmed	Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells.	LDHB LDHC	1.52e-05	4	56	2	11582518
Pubmed	Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.	SIX1 SIX2	1.52e-05	4	56	2	26884396
Pubmed	Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages.	LDHB LDHC	1.52e-05	4	56	2	11125887
Pubmed	Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.	SIX1 SIX2	1.52e-05	4	56	2	25670082
Pubmed	Six family genes control the proliferation and differentiation of muscle satellite cells.	SIX1 SIX2	1.52e-05	4	56	2	20696153
Pubmed	A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.	SIX1 SIX2	1.52e-05	4	56	2	30894749
Pubmed	Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.	SIX1 SIX2 CA2	1.72e-05	31	56	3	19898483
Pubmed	Tissue and developmental distribution of Six family gene products.	SIX1 SIX2	2.54e-05	5	56	2	9551859
Pubmed	SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors.	MRC1 ACE2	2.54e-05	5	56	2	32766577
Pubmed	Identification and expression of six family genes in mouse retina.	SIX1 SIX2	2.54e-05	5	56	2	8814301
Pubmed	Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.	SIX1 SIX2	2.54e-05	5	56	2	26034287
Pubmed	Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.	SIX1 SIX2	2.54e-05	5	56	2	25670083
Pubmed	Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.	SIX1 SIX2	2.54e-05	5	56	2	35178390
Pubmed	Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders.	LDHB LDHC	2.54e-05	5	56	2	20499337
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	SIX1 SIX2	3.80e-05	6	56	2	9826681
Pubmed	Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.	SIX1 SIX2	3.80e-05	6	56	2	20074369
Pubmed	The expression profile and clinic significance of the SIX family in non-small cell lung cancer.	SIX1 SIX2	3.80e-05	6	56	2	27821176
Pubmed	Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.	SIX1 SIX2	3.80e-05	6	56	2	19900183
Pubmed	Evaluation of multiple serum markers in advanced melanoma.	LDHB LDHC	3.80e-05	6	56	2	21858537
Pubmed	DISC1, PDE4B, and NDE1 at the centrosome and synapse.	PDE4D DISC1	5.32e-05	7	56	2	18983980
Pubmed	Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.	SIX1 SIX2	5.32e-05	7	56	2	20515681
Pubmed	Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons.	LDHB PLP1	5.32e-05	7	56	2	38587131
Pubmed	Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.	SIX1 SIX2	5.32e-05	7	56	2	12215533
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	SIX1 SIX2	7.09e-05	8	56	2	12441302
Pubmed	Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.	SIX1 SIX2	7.09e-05	8	56	2	10471511
Pubmed	Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.	SIX1 SIX2	7.09e-05	8	56	2	11950062
Pubmed	Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets.	SIX1 SIX2	7.09e-05	8	56	2	15183306
Pubmed	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.	SIX1 SIX2	7.09e-05	8	56	2	15634706
Pubmed	Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development.	SIX1 SIX2	7.09e-05	8	56	2	11313460
Pubmed	Pleiotropic effects in Eya3 knockout mice.	SIX1 SIX2	9.10e-05	9	56	2	19102749
Pubmed	Six1 is required for the early organogenesis of mammalian kidney.	SIX1 SIX2	9.10e-05	9	56	2	12783782
Pubmed	Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.	MRC1 SIX2	9.10e-05	9	56	2	30758286
Pubmed	Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme.	SIX1 SIX2	1.14e-04	10	56	2	16442091
Pubmed	A systematic analysis of a deep mouse epididymal sperm proteome.	LDHB LDHC	1.14e-04	10	56	2	23115268
Pubmed	Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.	SIX1 SIX2	1.14e-04	10	56	2	16938278
Pubmed	Regulation of metanephric kidney development by growth/differentiation factor 11.	ACVR2B SIX2	1.14e-04	10	56	2	12729564
Pubmed	TurboID-mediated proximity labeling technologies to identify virus co-receptors.	ACE2 LDHB	1.14e-04	10	56	2	38994005
Pubmed	Embryonic origin and remodeling of the urinary and digestive outlets.	SIX1 SIX2	1.39e-04	11	56	2	23390542
Pubmed	Homeobox genes and connective tissue patterning.	SIX1 SIX2	1.39e-04	11	56	2	7720577
Pubmed	Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.	SIX2 STAT4	1.39e-04	11	56	2	23638021
Pubmed	Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.	PDE4D DISC1	1.66e-04	12	56	2	19251251
Pubmed	Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.	SIX1 SIX2	1.96e-04	13	56	2	30905259
Pubmed	Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2.	PDE4D LDHB	1.96e-04	13	56	2	31545012
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	PLP1 CA2	2.29e-04	14	56	2	34630045
Pubmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	PHF20L1 L3MBTL3	2.64e-04	15	56	2	29691401
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4D DISC1	3.01e-04	16	56	2	28283561
Pubmed	Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.	SIX1 SIX2	3.41e-04	17	56	2	30367465
Pubmed	Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression.	SIX1 SIX2	3.41e-04	17	56	2	29771971
Pubmed	Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.	SIX1 SIX2	3.83e-04	18	56	2	14628042
Pubmed	Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.	SIX1 SIX2	3.83e-04	18	56	2	32243674
Pubmed	Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.	DISC1 PLP1	4.28e-04	19	56	2	28981898
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	ANGPTL3 BAZ1B	4.28e-04	19	56	2	19656773
Pubmed	The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.	SIX1 SIX2	4.28e-04	19	56	2	32554463
Pubmed	Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	PHF20L1 L3MBTL3	4.28e-04	19	56	2	30442713
Pubmed	The murine Fgfrl1 receptor is essential for the development of the metanephric kidney.	SIX1 SIX2	4.75e-04	20	56	2	19715689
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	MRC1 PRF1 MACROH2A2 BTAF1 INPP5F	5.47e-04	415	56	5	16385451
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	SIX1 SIX2	6.30e-04	23	56	2	18787044
Pubmed	Local regulation of fat metabolism in peripheral nerves.	LDHB PLP1	6.30e-04	23	56	2	14522948
Pubmed	Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.	SIX2 CA2	6.30e-04	23	56	2	33315499
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	GTDC1 ANKS1A	6.87e-04	24	56	2	17452356
Pubmed	Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.	SIX1 SIX2	6.87e-04	24	56	2	17036046
Pubmed	FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination.	SIX1 SIX2	6.87e-04	24	56	2	30188892
Pubmed	Overlapping functions of SIX homeoproteins during embryonic myogenesis.	SIX1 SIX2	6.87e-04	24	56	2	37267426
Pubmed	L3MBTL1, a histone-methylation-dependent chromatin lock.	L3MBTL1 CHD1	6.87e-04	24	56	2	17540172
Pubmed	Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.	PDE4D DISC1	6.87e-04	24	56	2	21821099
Pubmed	A single-cell time-lapse of mouse prenatal development from gastrula to birth.	CFH SIX2	7.46e-04	25	56	2	38355799
Pubmed	Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.	CFH CA2	8.71e-04	27	56	2	2574151
Pubmed	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	STAT4 ANKS1A	8.71e-04	27	56	2	23740937
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE4D PIK3C2G	8.71e-04	27	56	2	11156964
Pubmed	Dachshund homologues play a conserved role in islet cell development.	SIX1 SIX2	8.71e-04	27	56	2	20869363
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	MRC1 ANGPTL3 BAZ1B	8.81e-04	116	56	3	20139978
Pubmed	An N-terminal motif unique to primate tau enables differential protein-protein interactions.	LDHB PLP1 CA2	9.49e-04	119	56	3	29382714
Pubmed	Biochemical diversity and evolution in the genus Mus.	LDHB CA2	1.08e-03	30	56	2	6375655
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	L3MBTL1 SIX2	1.15e-03	31	56	2	27798109
Pubmed	The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.	CFH CA2	1.15e-03	31	56	2	2165966
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	SIX1 SIX2	1.22e-03	32	56	2	34193412
Pubmed	Tudor, MBT and chromo domains gauge the degree of lysine methylation.	L3MBTL1 PHF20L1	1.30e-03	33	56	2	16415788
Pubmed	Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.	CFH PRF1	1.55e-03	36	56	2	7558020
GeneFamily	SINE class homeoboxes	SIX1 SIX2	6.08e-05	6	37	2	525
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL1 L3MBTL3	1.45e-04	9	37	2	1263
GeneFamily	Sterile alpha motif domain containing	L3MBTL1 L3MBTL3 ANKS1A	7.68e-04	88	37	3	760
GeneFamily	C-type lectin domain family	MRC1 CLEC2A	4.16e-03	47	37	2	494
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D PIK3C2G FRMPD1 GCSAM	1.41e-06	153	56	5	79c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D PIK3C2G ANGPTL3 LDHB	1.99e-06	164	56	5	8f3255d7f67890389a768453492243ea982eb38a
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TCAF2 PDE4D LDHB STAT4 GCSAM	4.41e-06	193	56	5	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	PDE4D USP22 PRF1 CHD1 STAT4	5.12e-06	199	56	5	945fbf5845403a8b22d04963f50ad69c414b6153
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D PIK3C2G FRMPD1 MACROH2A2	2.52e-05	135	56	4	7b456fa9a5f5ce58976a8f1fad18c0f96a096930
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D ZNF85 STAT4	3.52e-05	147	56	4	5e6dd2ddc67b3722f6528e7277cbc7f296098687
ToppCell	VE-CD8-memory_CD4\|VE / Condition, Cell_class and T cell subcluster	CFH PRF1 FRMPD1 STAT4	4.01e-05	152	56	4	9401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRF1 STAT4 GCSAM	4.09e-05	53	56	3	2147787ed3de18b49f51a8518984c7b6ba9a8cef
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D PIK3C2G GCSAM	4.12e-05	153	56	4	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEMP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZNF823 SLC27A6 MACROH2A2 LDHB	4.12e-05	153	56	4	14753baa9980f75206fefc3c8b43685fd4178a43
ToppCell	severe_COVID-19-MAIT\|World / disease group, cell group and cell class (v2)	CFH PDE4D FZD3 STAT4	4.22e-05	154	56	4	65ec7f7ef05c589903c4c9fe3849478c325fdc61
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D PIK3C2G GCSAM	4.55e-05	157	56	4	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D PIK3C2G FRMPD1	4.78e-05	159	56	4	50d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D PRF1 STAT4	5.52e-05	165	56	4	5e7ee76f3dcddbd1b560bacd043f9001b0c18b5f
ToppCell	severe_influenza-CD4+_CTL\|World / disease group, cell group and cell class (v2)	CFH PRF1 STAT4 SPRED3	5.65e-05	166	56	4	cdc3e200373718f26fe02ee516928097103f46e2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D PRF1 STAT4 SPRED3	5.79e-05	167	56	4	ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MRC1 PHF20L1 FRMPD1 SPARCL1	5.92e-05	168	56	4	3fb79aaa858057c82645a90bd139fc4f096323c7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D LDHB STAT4 GCSAM	6.06e-05	169	56	4	01a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-MAIT\|Multiple_Sclerosis / Disease, Lineage and Cell Type	CFH PDE4D PRF1 STAT4	6.49e-05	172	56	4	18bda0038cb37da6784e7bf7291272c108cfd9c5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PIK3C2G SPARCL1 SIX1	7.09e-05	176	56	4	cb21342dd135cc80a50aafe7bf8bf31265db68dd
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH LDHB LDHC CLEC2A	7.25e-05	177	56	4	9e65b39fd797b6ce204b6480415810d1923acee5
ToppCell	IIF-Lymphocyte-T_NK-MAIT\|IIF / Disease, Lineage and Cell Type	CFH PDE4D PRF1 STAT4	7.41e-05	178	56	4	be777ebef8f09a1a16fcee8fc69a65ab295b6e1d
ToppCell	10x5'v1-week_17-19-Lymphocytic_NK-T_NK-ILC_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH SLC27A6 PRF1 STAT4	7.57e-05	179	56	4	d18a520568cf4b031972d3dd7d4d4bd073ac1fea
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCAF2 PDE4D STAT4 GCSAM	7.57e-05	179	56	4	a634ca46ffc394c5f5215fc5d8eae4a77819af9c
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCAF2 PDE4D STAT4 GCSAM	7.57e-05	179	56	4	35f014b6e752626909d829c5ab9bb761c1f3e3dc
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH SHROOM3 SIX1 RNF145	7.74e-05	180	56	4	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-T_mait\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TCAF2 PDE4D PRF1 STAT4	7.74e-05	180	56	4	e53e9f3ebd48fb8237515e740ba5d9880ed6ade3
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-T_mait-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TCAF2 PDE4D PRF1 STAT4	7.74e-05	180	56	4	9d18aa1044945fe6481ea3284037a777657fd837
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH PDE4D PRF1 STAT4	8.07e-05	182	56	4	f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCell	COVID-19_Severe-Lymphoid_T/NK-MAIT\|COVID-19_Severe / Disease group, lineage and cell class	CFH PDE4D PRF1 STAT4	8.07e-05	182	56	4	19045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CFH PDE4D PRF1 STAT4	8.07e-05	182	56	4	cccac9f85825f4e310b86e37ee6320769a670501
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRF1 GTDC1 STAT4 GCSAM	8.07e-05	182	56	4	9d727ab84da8de33f1021b492c90d8b4c2a8ea23
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH PDE4D PRF1 STAT4	8.07e-05	182	56	4	1444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFH PDE4D PRF1 STAT4	8.07e-05	182	56	4	49eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCell	droplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH SHROOM3 PIK3C2G SPARCL1	8.42e-05	184	56	4	89ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH SHROOM3 PIK3C2G SPARCL1	8.42e-05	184	56	4	4df6027fa635996c1eddb920f88a5265772df1cd
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 DISC1 TBC1D7 PLP1	8.60e-05	185	56	4	554c5d812197fbf66bf279fcc953277e926ade15
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D PRF1 STAT4	8.96e-05	187	56	4	f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D LDHB STAT4	8.96e-05	187	56	4	e1d6c1194476cf26969e405b0951796fed519f44
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D LDHB GCSAM	9.15e-05	188	56	4	3e3055dacc05a932f2beb114babf1dc76994e1af
ToppCell	ILEUM-inflamed-(1)_Cytotoxic_CD8_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PDE4D PRF1 STAT4 CA2	9.15e-05	188	56	4	d26894d1066a70e4b32ae41fff1c4718f2591ba9
ToppCell	Severe-Myeloid-Macrophages-\|Severe / Condition, Lineage, Cell class and cell subclass	PDE4D PRF1 LDHB STAT4	9.34e-05	189	56	4	769b52073a0f0543a72e9f32772321194b70cb2f
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT\|lymph-node_spleen / Manually curated celltypes from each tissue	CFH PRF1 STAT4 CA2	9.34e-05	189	56	4	afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like\|lymph-node_spleen / Manually curated celltypes from each tissue	CFH PRF1 STAT4 CA2	9.53e-05	190	56	4	0c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCell	Severe-MAIT\|World / Disease group and Cell class	CFH PDE4D PRF1 CA2	9.53e-05	190	56	4	7a92e0d6a021be23125495927b8571e25c83204a
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D PRF1 STAT4	9.53e-05	190	56	4	05e6af222d0ad97cb69f399a96c9038f9dd989b9
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 ABCA13 LDHB PLP1	9.53e-05	190	56	4	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell\|NK_cell / Lineage, cell class and subclass	CFH SHROOM3 LDHB GCSAM	9.53e-05	190	56	4	16e408436fa663cdf86e38311a7aed4e02c28579
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 ABCA13 LDHB PLP1	9.53e-05	190	56	4	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	Severe-MAIT\|Severe / Disease group and Cell class	CFH PDE4D PRF1 CA2	9.53e-05	190	56	4	1c063dc1b62d9f9912aaf8d0297555a6545f5550
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH SHROOM3 SIX1 RNF145	9.73e-05	191	56	4	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D LDHB GCSAM	9.73e-05	191	56	4	b53b490a8796e819edd3eb4a5a42b4499077b2d3
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PDE4D LDHB GCSAM	9.73e-05	191	56	4	9c747f8cc1cdce45e839b661d782e1e8cfb79578
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PRF1 LDHB STAT4	9.73e-05	191	56	4	b9ef6d82b86271b7e0875a399bb9aae84ef5bad3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFH PDE4D PRF1 STAT4	9.92e-05	192	56	4	892789bdba150ef9a8a0012de52545f2ff6a31f6
ToppCell	COVID-19_Mild-Lymphoid_T/NK-MAIT\|COVID-19_Mild / Disease group, lineage and cell class	CFH PDE4D PRF1 STAT4	9.92e-05	192	56	4	d47bd132e57f5b4bddcf3dfa399cee149eca7e44
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH PDE4D PRF1 STAT4	9.92e-05	192	56	4	24ea8fdcca2695aeb2e4b88161184124b7d332c1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CFH PDE4D PRF1 STAT4	9.92e-05	192	56	4	44f440ee3842fe14665c4cd4f2aa48e7a5bbd9a8
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH PDE4D PRF1 STAT4	9.92e-05	192	56	4	8d50ad8cfe3cb9f183188b08457756af0ce56ffe
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CFH SHROOM3 SIX1 RNF145	1.01e-04	193	56	4	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	normal_Lymph_Node-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	ANKRD10 MACROH2A2 RNF145 GCSAM	1.01e-04	193	56	4	024d30eb143d8278c0851c3a6c9426226fa3b480
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH ZNF556 SPARCL1 SIX1	1.01e-04	193	56	4	02dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 STAT4 CA2	1.05e-04	195	56	4	caa3669739974b63470f7e557df96e8d3844dd84
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 STAT4 CA2	1.05e-04	195	56	4	bc5728e9df0b15adec50a7c840ce9f2775135087
ToppCell	mild_COVID-19\|World / disease group, cell group and cell class (v2)	PDE4D CHD1 LDHB STAT4	1.05e-04	195	56	4	6dbe9db5f0e94f2e91b3d1282855d200051ab0ba
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH SHROOM3 SIX1 RNF145	1.05e-04	195	56	4	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	COVID-CD4-memory_CD4\|COVID / Condition, Cell_class and T cell subcluster	CFH PDE4D LDHB STAT4	1.07e-04	196	56	4	a4fb3abf3c38928da9e8281dee8a304e8fd55eab
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D PRF1 LDHB STAT4	1.07e-04	196	56	4	e4c76e7ad68455e51fe93ce588bcec9383f8654b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D PRF1 LDHB STAT4	1.07e-04	196	56	4	c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCell	severe_COVID-19-CD8+_Tem\|World / disease group, cell group and cell class (v2)	PDE4D PRF1 LDHB STAT4	1.07e-04	196	56	4	f0d3067b0f596dd84da2af4bf062fb9f04ef1dc4
ToppCell	normal-na-Lymphocytic_NK-T_mait\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CFH PDE4D PRF1 STAT4	1.10e-04	197	56	4	5abe983f9750085ec7b57bcb8c36bdfe78a6ee4c
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 LDHB STAT4	1.10e-04	197	56	4	adc7bf2120fad4aea58123d882a8cf18ed4174d0
ToppCell	AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	PDE4D PIK3C2G BAZ1B RNF145	1.10e-04	197	56	4	fd7bdfa6bf5966ebc11fdd13915769429540ddbf
ToppCell	mild_COVID-19-CD8+_Tem\|World / disease group, cell group and cell class (v2)	PDE4D PRF1 LDHB STAT4	1.10e-04	197	56	4	97fead264e986d922669a6006cbcec530c697df7
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-T_mait-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFH PDE4D PRF1 STAT4	1.10e-04	197	56	4	a4ecac6ee8a0d4d85319104c179ec7711a3efb51
ToppCell	BL-critical-LOC-Lymphoid-CTL\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDE4D PRF1 LDHB STAT4	1.10e-04	197	56	4	fb70918867fbd111bb192a797dcafed5f39ea299
ToppCell	356C-Epithelial_cells-Epithelial-A_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE4D RNF145 LDHB CA2	1.10e-04	197	56	4	0de77f04612b66cc637dab5d5432c6e711e5964e
ToppCell	Control-Lymphoid-CD4_T_cells\|Control / Condition, Lineage and Cell class	TCAF2 PDE4D PRF1 STAT4	1.10e-04	197	56	4	dad6479caac07c1536f2b3082a51d61ae08beca0
ToppCell	3'-Broncho-tracheal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH ABCA13 SIX1 LDHB	1.10e-04	197	56	4	5d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell	normal-na-Lymphocytic_NK-T_mait-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CFH PDE4D PRF1 STAT4	1.10e-04	197	56	4	8752c0f37979aa7bf2e8aee6990fb6307a6666b7
ToppCell	URO-Myeloid-cDC2\|URO / Disease, Lineage and Cell Type	MRC1 TBC1D7 LDHB CA2	1.10e-04	197	56	4	7fee14356d7fba68a0515c8b9284568d14124b0a
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-T_mait\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFH PDE4D PRF1 STAT4	1.10e-04	197	56	4	653f5cfc44bc3b9218fa187df3d1d828070c2d44
ToppCell	356C-Epithelial_cells-Epithelial-A_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE4D RNF145 LDHB CA2	1.10e-04	197	56	4	a01640e31fc33c1ab512b4d3eddae8342ecf182c
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 LDHB STAT4	1.10e-04	197	56	4	e133bd09efc6d7f539fc1a1ac7a945f07103d6e6
ToppCell	BL-critical-LOC-Lymphoid\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDE4D PRF1 LDHB STAT4	1.12e-04	198	56	4	1c0227e58a64c0bf509bfb9578fb91277316b120
ToppCell	Severe_COVID-19-T/NK-CD8+_T\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	PDE4D PRF1 LDHB STAT4	1.12e-04	198	56	4	584f0dc6f22bb13956a5f6950698599e382907e9
ToppCell	mLN-T_cell-Th17\|T_cell / Region, Cell class and subclass	PDE4D ACVR2B STAT4 CA2	1.12e-04	198	56	4	efdc9515dd9fb20ef9c8ddc106d88cbdde7d6ea2
ToppCell	AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PDE4D RNF145 LDHB CA2	1.12e-04	198	56	4	893036558a9ad86b57f9e735df35812e9d18739e
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PDE4D PRF1 LDHB STAT4	1.12e-04	198	56	4	2eb80255bacddbf778b1c9eec09f74b4cdb09b36
ToppCell	BL-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH ABCA13 SPARCL1 SIX1	1.12e-04	198	56	4	484d16aaa601a1e11b871b0475dd01a2de1a29ce
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE4D PRF1 LDHB STAT4	1.12e-04	198	56	4	ec99da4e269c4cd982a395cdac0e4487ab14ec39
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE4D PRF1 LDHB STAT4	1.12e-04	198	56	4	06fdf8554148d11c0a946a7fd200edd9fa7e1965
ToppCell	COVID-19_Moderate-CD4+_CTL\|World / disease group, cell group and cell class	CFH PDE4D PRF1 STAT4	1.14e-04	199	56	4	12ea0346b4da3e8e2b3b2b3b3e9d4f4f104345a6
ToppCell	PBMC-Mild-Lymphocyte-T/NK\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 LDHB STAT4	1.14e-04	199	56	4	dfdf551a292e33e3ee356629fa48a0a2f009624d
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH PHF20L1 SPARCL1 RNF145	1.14e-04	199	56	4	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CFH PDE4D PRF1 STAT4	1.14e-04	199	56	4	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	BAL-Severe-Lymphocyte-T/NK\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D PRF1 LDHB STAT4	1.14e-04	199	56	4	28cec7122b143373f1c7c94acf35bf8f896e0d57
ToppCell	Severe_COVID-19-T/NK\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	PDE4D PRF1 LDHB STAT4	1.14e-04	199	56	4	ace179b860513179e9275ed40ae1985a98385026
ToppCell	PBMC-Mild-Lymphocyte-T/NK\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE4D PRF1 LDHB STAT4	1.14e-04	199	56	4	ec7a1b0b71175b3a4015522bf88784eb176d59e3
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 PDE4D RNF145 CA2	1.14e-04	199	56	4	2dc33804f6691d7c9682e6c9b885e945fb97fc36
Drug	ox-Q	LDHB LDHC	3.18e-05	4	53	2	CID000448650
Drug	spirobishexahydropyrimidine	LDHB LDHC	5.29e-05	5	53	2	CID000100750
Drug	AC1O5TJF	LDHB LDHC	5.29e-05	5	53	2	CID006440410
Drug	1,4-diethoxybutane	LDHB LDHC	5.29e-05	5	53	2	CID000232578
Drug	C4H3NO4	LDHB LDHC	5.29e-05	5	53	2	CID000448651
Drug	S-lac-NAD	LDHB LDHC	5.29e-05	5	53	2	CID000194292
Drug	sorbarin	LDHB LDHC	5.29e-05	5	53	2	CID009824100
Drug	acetylphosphonic acid	LDHB LDHC	5.29e-05	5	53	2	CID000081311
Drug	NSC-60195	LDHB LDHC	5.29e-05	5	53	2	CID000020481
Drug	ethyl gossypol	LDHB LDHC	5.29e-05	5	53	2	CID000374353
Drug	AC1O5ZB9	LDHB LDHC	5.29e-05	5	53	2	CID006443605
Drug	AC1L49DG	LDHB LDHC	5.29e-05	5	53	2	CID000152931
Drug	oxyayanin A	LDHB LDHC	5.29e-05	5	53	2	CID005281676
Drug	B-HAD	LDHB LDHC	5.29e-05	5	53	2	CID000131338
Drug	SQ 31,486	LDHB LDHC	5.29e-05	5	53	2	CID000130015
Drug	N-trifluoroacetyl-glycine	LDHB LDHC	5.29e-05	5	53	2	CID000136227
Drug	BMS-188107	LDHB LDHC	5.29e-05	5	53	2	CID000192297
Drug	AC1L24G8	LDHB LDHC	7.93e-05	6	53	2	CID000066023
Drug	BL-443	LDHB LDHC	7.93e-05	6	53	2	CID000054436
Drug	oxymethacil	LDHB LDHC	7.93e-05	6	53	2	CID000096369
Drug	dansyl-L-lysine	LDHB LDHC	7.93e-05	6	53	2	CID000598797
Drug	I 65	LDHB LDHC	7.93e-05	6	53	2	CID000149068
Drug	D 701	LDHB LDHC	7.93e-05	6	53	2	CID003051460
Drug	2,3-dihydroxy-1-naphthoic acid	LDHB LDHC	7.93e-05	6	53	2	CID000028002
Drug	SQ 32,926	LDHB LDHC	7.93e-05	6	53	2	CID000131363
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	L3MBTL1 PRF1 ACVR2B SIX1 LDHC	8.16e-05	191	53	5	1227_UP
Drug	Pepstatin A [26305-03-3]; Down 200; 5.8uM; PC3; HT_HG-U133A	PDE4D L3MBTL1 DISC1 FRMPD1 SIX2	9.22e-05	196	53	5	4206_DN
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	PHF20L1 SLC27A6 ACVR2B SIX1 GTDC1	9.67e-05	198	53	5	7011_UP
Drug	Methyldopa (L,-) [555-30-6]; Down 200; 19uM; PC3; HT_HG-U133A	PDE4D L3MBTL1 PRF1 FRMPD1 BAZ1B	9.90e-05	199	53	5	4677_DN
Drug	N-acetyl-9-O-lactylneuraminic acid	LDHB LDHC	1.11e-04	7	53	2	CID000191486
Drug	sodium glycolate	LDHB LDHC	1.11e-04	7	53	2	CID000517347
Drug	AC1O7170	LDHB LDHC	1.11e-04	7	53	2	CID006540699
Drug	AC1NSM0G	LDHB LDHC	1.11e-04	7	53	2	CID005365671
Drug	BS35	LDHB LDHC	1.11e-04	7	53	2	CID000029316
Drug	BS36	LDHB LDHC	1.11e-04	7	53	2	CID000029308
Drug	pentabromoacetone	LDHB LDHC	1.11e-04	7	53	2	CID000065579
Drug	Pentoprilum	ACE2 CA2	1.11e-04	7	53	2	CID000054938
Drug	methyl-4-hydroxy-3-nitrobenzimidate	LDHB LDHC	1.11e-04	7	53	2	CID005492576
Drug	gossylic iminolactone	LDHB LDHC	1.11e-04	7	53	2	CID005479302
Drug	Primal	LDHB LDHC POTEC	1.38e-04	43	53	3	CID001549157
Drug	fluorobenzene	LDHB LDHC CA2	1.38e-04	43	53	3	CID000010008
Drug	U75412E	LDHB LDHC	1.48e-04	8	53	2	CID003035460
Drug	AC1Q3O0A	LDHB LDHC	1.48e-04	8	53	2	CID000060880
Drug	UR-12633	LDHB LDHC	1.48e-04	8	53	2	CID000128030
Drug	p-(phenoxypropoxy)aniline	LDHB LDHC	1.48e-04	8	53	2	CID000423258
Drug	2-methyl-2-pentenoate	LDHB LDHC	1.48e-04	8	53	2	CID000018458
Drug	BS37	LDHB LDHC	1.48e-04	8	53	2	CID000027925
Drug	AC1L4GHU	LDHB LDHC	1.48e-04	8	53	2	CID000156607
Drug	N-dodecyl morpholine	LDHB LDHC	1.48e-04	8	53	2	CID000073764
Drug	S-(2-chloroethyl)-L-cysteine	LDHB LDHC	1.48e-04	8	53	2	CID000034229
Drug	neutral red	ACE2 LDHB LDHC	1.80e-04	47	53	3	CID000011105
Drug	benzamyl	LDHB LDHC	1.89e-04	9	53	2	CID000160884
Drug	Bcdfg	LDHB LDHC	1.89e-04	9	53	2	CID003036106
Drug	N-acetyl-ala-ala-ala-methyl ester	LDHB LDHC	1.89e-04	9	53	2	CID000100120
Drug	guanidine hydrochloride	LDHB PLP1 LDHC CA2	2.32e-04	129	53	4	CID000005742
Drug	FK3311	LDHB LDHC	2.36e-04	10	53	2	CID000164009
Drug	2-keto-4-mercaptobutyric acid	LDHB LDHC	2.36e-04	10	53	2	CID000151198
Drug	hydroxyisonobilin	LDHB LDHC	2.36e-04	10	53	2	CID006438562
Drug	bis-NAD	LDHB LDHC	2.36e-04	10	53	2	CID003081557
Drug	pyridinophane cryptand	LDHB LDHC	2.36e-04	10	53	2	CID006454246
Drug	sodium oxamate	LDHB LDHC	2.36e-04	10	53	2	CID000005242
Drug	mivazerol	LDHB LDHC	2.36e-04	10	53	2	CID000060783
Drug	phosphoenolthiopyruvate	LDHB LDHC	2.36e-04	10	53	2	CID000194910
Drug	BNPS-skatole	LDHB PLP1 LDHC	2.72e-04	54	53	3	CID000094388
Drug	9-benzyladenine	PDE4D CA2	2.89e-04	11	53	2	CID000020262
Drug	5-ethylphenazin-5-ium	LDHB LDHC	2.89e-04	11	53	2	CID000082689
Drug	hydrazinium nitrate	LDHB LDHC	2.89e-04	11	53	2	CID000166817
Drug	hexandiol	LDHB LDHC	2.89e-04	11	53	2	CID000147023
Drug	polyvinylpyridine-N-oxide	LDHB LDHC	2.89e-04	11	53	2	CID000024772
Drug	LG61	LDHB LDHC	3.46e-04	12	53	2	CID000520177
Drug	U74500A	LDHB LDHC	3.46e-04	12	53	2	CID000107964
Drug	tauroursocholate	PIK3C2G LDHB LDHC CA2	3.72e-04	146	53	4	CID000005246
Drug	diphenaldehyde	LDHB LDHC	4.08e-04	13	53	2	CID000014585
Drug	3-mercaptolactic acid	LDHB LDHC	4.08e-04	13	53	2	CID000160645
Drug	2-oxohexanoate	LDHB LDHC	4.08e-04	13	53	2	CID000159664
Drug	T 514	LDHB LDHC	4.08e-04	13	53	2	CID000114820
Drug	fructose-1,6-diphosphate sodium salt	PRF1 LDHB LDHC POTEC	4.23e-04	151	53	4	CID000000718
Drug	longum	DISC1 LDHB LDHC	4.29e-04	63	53	3	CID000009047
Disease	semaphorin-6A measurement	CFH MRC1	1.82e-05	4	52	2	EFO_0020721
Disease	isochorismatase domain-containing protein 1 measurement	CFH SLC27A6	1.82e-05	4	52	2	EFO_0801735
Disease	Situs ambiguus	SHROOM3 ACVR2B	3.15e-04	15	52	2	C0266642
Disease	COVID-19 (is_implicated_in)	CFH ACE2	6.26e-04	21	52	2	DOID:0080600 (is_implicated_in)
Disease	disease of metabolism (implicated_via_orthology)	LDHB LDHC	6.26e-04	21	52	2	DOID:0014667 (implicated_via_orthology)
Disease	depressive disorder (implicated_via_orthology)	PDE4D PLP1	6.88e-04	22	52	2	DOID:1596 (implicated_via_orthology)
Disease	Oral ulcer	PDE4D GTDC1 STAT4	9.00e-04	107	52	3	HP_0000155
Disease	systemic scleroderma, systemic lupus erythematosus	STAT4 ANKS1A	9.64e-04	26	52	2	EFO_0000717, MONDO_0007915
Disease	brain cancer (implicated_via_orthology)	L3MBTL1 L3MBTL3	9.64e-04	26	52	2	DOID:1319 (implicated_via_orthology)
Disease	Bilateral Wilms Tumor	SIX1 SIX2	1.20e-03	29	52	2	C2930471

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVHWAAHFGKLECLV	ANKRD10	61	Q9NXR5
PAEFCWKGTLHGQEK	ADIG	61	Q0VDE8
LWCHVHLKKSLSGSP	BAZ1B	336	Q9UIG0
SHHAKPKPGVQWCKF	GVQW3	161	Q3ZCU0
KFVIHCHIPQWGSDK	MACROH2A2	271	Q9P0M6
GHVGGCHPKWSEAKN	ABCA13	326	Q86UQ4
DHHIAEGCFCLPWKK	GCSAM	36	Q8N6F7
FSTWDHKAKGHFNCP	ANGPTL3	381	Q9Y5C1
SKGCYPLHLAAWKGD	ANKS1A	111	Q92625
FVCVGTKAKGVPHAW	CEP76	396	Q8TAP6
DGPAIAKCLGEKWSH	CFH	966	P08603
PCHTKAAHFDIDWGK	CHD1	1241	O14646
EWKTHLIPSLHCAGG	DISC1	751	Q9NRI5
NKECSWGSPIGKHHG	PIK3C2G	121	O75747
WCEKTGHKLHPPKGY	L3MBTL3	321	Q96JM7
AKGACPWKEHLYHLE	MYG1	266	Q9HB07
PDIHPAGWFEKTGHK	L3MBTL1	356	Q9Y468
CKRSHKFVPGAWLAG	PRF1	31	P14222
AGGATLKAPKHLWRH	PDE4D	21	Q08499
EKLGVHPTSCHGWII	LDHC	176	P07864
KHFGGEMAVKLPHLW	BTAF1	1036	O14981
GVGNKHPPEKCTWHF	FRMPD1	1441	Q5SYB0
KAVCHPTAWDLGKGD	ACE2	341	Q9BYF1
KKALLFHASAWGIPG	FZD3	326	Q9NPG1
AEKLGIHPSSCHGWI	LDHB	176	P07195
KGEIAPFSWAALHGK	GTDC1	431	Q4AE62
KFHGGWALIDCDPSL	INPP5F	616	Q9Y2H2
KWFHHRFPCCKGSGK	POTEC	26	B2RU33
KNKHHPDLHLWACSG	PHF20L1	796	A8MW92
AKFVCKHWAEGVTHP	MRC1	621	P22897
SALDFHWPFGGALCK	RXFP4	101	Q8TDU9
ECFKIHHPWGTIKAQ	TRIM36	181	Q9NQ86
LLKEDLVWGAFGCHP	TATDN2	551	Q93075
IKAHLGKGAPLCDWN	TCAF2	811	A6NFQ2
FKAHDKVCIGAVWHP	CDC40	546	O60508
LFHHLTPRWGGSGCK	SHROOM3	1291	Q8TF72
GRFLWSLPACDHLHK	SIX1	31	Q15475
HACWAIKELDGSFKP	CCT8L1P	186	A6NM43
HACWAIKELDGSFKP	CCT8L2	186	Q96SF2
SKAIDLWHKHCGTPV	TBC1D7	276	Q9P0N9
NGPEHWHKDFPIAKG	CA2	11	P00918
KDHWLKHPGLAQLCV	ACVR2B	441	Q13705
KHAKPVACSGDWLGV	CLEC2A	51	Q6UVW9
LCGKAFVWPSLFHLH	ZNF823	196	P16415
PGCSHLGSFKVDNWK	USP22	21	Q9UPT9
IRKGSFIHKPAHGWL	SHC2	126	P98077
GHLTWAKFCKEHLPG	STAT4	531	Q14765
HITLKEWGHCFGIKE	SPARCL1	641	Q14515
NPIFHHWSLGDCKFG	SPRED3	76	Q2MJR0
GKAFGWPSSLHKHAR	ZNF556	321	Q9HAH1
EVHYWKVKGSPSHCL	TEX50	41	A0A1B0GTY4
GRFLWSLPACEHLHK	SIX2	31	Q9NPC8
ECGKGFKWPSTLTIH	ZNF85	486	Q03923
PDFVHVWFGLAKLGC	SLC27A6	116	Q9Y2P4
PCSHFFHAGCLKKWL	RNF145	551	Q96MT1
CLGKWLGHPDKFVGI	PLP1	141	P60201