Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	recombination hotspot binding	PRDM9 PRDM7	4.75e-06	2	44	2	GO:0010844
GeneOntologyMolecularFunction	pheromone binding	OBP2B OBP2A	4.73e-05	5	44	2	GO:0005550
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	PRDM9 PRDM7	3.64e-04	13	44	2	GO:0046975
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	PRDM9 PRDM7	8.79e-04	20	44	2	GO:0042800
GeneOntologyMolecularFunction	tau-protein kinase activity	TAOK2 TAOK1	1.07e-03	22	44	2	GO:0050321
GeneOntologyMolecularFunction	protein serine kinase activity	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	1.17e-03	363	44	5	GO:0106310
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	TAOK2 MAP3K10	1.61e-03	27	44	2	GO:0004709
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK3 HERC2 TRIO FARP1	1.65e-03	231	44	4	GO:0005085
GeneOntologyBiologicalProcess	positive regulation of reciprocal meiotic recombination	PRDM9 PRDM7	2.66e-05	4	44	2	GO:0010845
GeneOntologyBiologicalProcess	regulation of reciprocal meiotic recombination	PRDM9 PRDM7	2.66e-05	4	44	2	GO:0010520
Domain	von_Ebner_gland	OBP2B OBP2A	1.70e-05	3	45	2	IPR002450
Domain	SSXRD	PRDM9 PRDM7	1.57e-04	8	45	2	PF09514
Domain	SSXRD_motif	PRDM9 PRDM7	1.57e-04	8	45	2	IPR019041
Domain	SET	PRDM9 PRDM7 PRDM14	1.85e-04	46	45	3	SM00317
Domain	SET_dom	PRDM9 PRDM7 PRDM14	2.37e-04	50	45	3	IPR001214
Domain	SET	PRDM9 PRDM7 PRDM14	2.37e-04	50	45	3	PS50280
Domain	KRAB_RELATED	PRDM9 PRDM7	3.08e-04	11	45	2	PS50806
Domain	Krueppel-associated_box-rel	PRDM9 PRDM7	4.35e-04	13	45	2	IPR003655
Domain	LIPOCALIN	OBP2B OBP2A	7.54e-04	17	45	2	PS00213
Domain	Lipocalin	OBP2B OBP2A	8.47e-04	18	45	2	IPR002345
Domain	SH3_2	DOCK3 MAP3K10 AMPH	1.16e-03	86	45	3	IPR011511
Domain	SH3_2	DOCK3 MAP3K10 AMPH	1.16e-03	86	45	3	PF07653
Domain	Ser/Thr_kinase_AS	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	1.62e-03	357	45	5	IPR008271
Domain	S_TKc	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	1.66e-03	359	45	5	SM00220
Domain	PROTEIN_KINASE_ST	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	1.72e-03	362	45	5	PS00108
Domain	SH3	DOCK3 MAP3K10 AMPH TRIO	1.79e-03	216	45	4	SM00326
Domain	SH3	DOCK3 MAP3K10 AMPH TRIO	1.79e-03	216	45	4	PS50002
Domain	SH3_domain	DOCK3 MAP3K10 AMPH TRIO	1.91e-03	220	45	4	IPR001452
Domain	HECT	HERC2 HECW1	1.92e-03	27	45	2	PF00632
Domain	HECTc	HERC2 HECW1	1.92e-03	27	45	2	SM00119
Domain	HECT_dom	HERC2 HECW1	1.92e-03	27	45	2	IPR000569
Domain	HECT	HERC2 HECW1	1.92e-03	27	45	2	PS50237
Domain	Pkinase	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	2.15e-03	381	45	5	PF00069
Domain	PH	TRIO CDC42BPB FARP1 PHLDB2	2.21e-03	229	45	4	PF00169
Domain	Lipocln_cytosolic_FA-bd_dom	OBP2B OBP2A	3.03e-03	34	45	2	IPR000566
Domain	Lipocalin	OBP2B OBP2A	3.03e-03	34	45	2	PF00061
Domain	-	OBP2B OBP2A	3.21e-03	35	45	2	2.40.128.20
Domain	Calycin	OBP2B OBP2A	3.58e-03	37	45	2	IPR012674
Domain	Calycin-like	OBP2B OBP2A	3.58e-03	37	45	2	IPR011038
Domain	GDS_CDC24_CS	TRIO FARP1	3.97e-03	39	45	2	IPR001331
Domain	SET	PRDM9 PRDM14	4.38e-03	41	45	2	PF00856
Domain	PH	TRIO CDC42BPB FARP1 PHLDB2	4.43e-03	278	45	4	SM00233
Domain	PH_DOMAIN	TRIO CDC42BPB FARP1 PHLDB2	4.49e-03	279	45	4	PS50003
Domain	PH_domain	TRIO CDC42BPB FARP1 PHLDB2	4.55e-03	280	45	4	IPR001849
Domain	PROTEIN_KINASE_ATP	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	4.77e-03	459	45	5	PS00107
Domain	Prot_kinase_dom	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	6.22e-03	489	45	5	IPR000719
Domain	PROTEIN_KINASE_DOM	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	6.43e-03	493	45	5	PS50011
Domain	SH3_1	MAP3K10 AMPH TRIO	7.20e-03	164	45	3	PF00018
Domain	Kinase-like_dom	TAOK2 MAP3K10 TAOK1 TRIO CDC42BPB	9.49e-03	542	45	5	IPR011009
Pathway	PID_P38_MKK3_6PATHWAY	TAOK2 MAP3K10 TAOK1	3.51e-05	26	35	3	M20
Pathway	WP_MICROTUBULE_CYTOSKELETON_REGULATION	TAOK1 TRIO PHLDB2	2.25e-04	48	35	3	M39566
Pubmed	The yin-yang of PR-domain family genes in tumorigenesis.	PRDM9 PRDM7 PRDM14	8.06e-08	7	47	3	10668202
Pubmed	SET domains and histone methylation.	PRDM9 PRDM7 PRDM14	1.29e-07	8	47	3	14675547
Pubmed	A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres.	OBP2B OBP2A	1.79e-06	2	47	2	10607840
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	1.79e-06	2	47	2	28830982
Pubmed	Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties.	OBP2B OBP2A	1.79e-06	2	47	2	12044155
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 DOCK3 MAP3K10 AMPH HECW1 GPRIN1 TRIO CDC42BPB FARP1 DNAJC11	2.35e-06	1139	47	10	36417873
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	5.36e-06	3	47	2	9786855
Pubmed	Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ.	OBP2B OBP2A	5.36e-06	3	47	2	7813422
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	5.36e-06	3	47	2	17396146
Pubmed	Adipose-derived lipocalin 14 alleviates hyperglycaemia by suppressing both adipocyte glycerol efflux and hepatic gluconeogenesis in mice.	OBP2B OBP2A	5.36e-06	3	47	2	26592241
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	5.36e-06	3	47	2	23585562
Pubmed	An increase in expression of the lipocalin 24p3 is found in mouse uterus coincident with birth.	OBP2B OBP2A	1.07e-05	4	47	2	7544071
Pubmed	Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.	MYZAP CDC42BPB	1.07e-05	4	47	2	21240187
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	1.07e-05	4	47	2	10497253
Pubmed	Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.	PRDM9 PRDM7	1.07e-05	4	47	2	18231586
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	1.78e-05	5	47	2	13679851
Pubmed	Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.	TAOK2 TAOK1	1.78e-05	5	47	2	22683681
Pubmed	The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.	TAOK2 TAOK1	2.67e-05	6	47	2	12639963
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	TAOK2 TAOK1	2.67e-05	6	47	2	16893890
Pubmed	Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.	OBP2B OBP2A	4.98e-05	8	47	2	23267103
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 LPGAT1 MYOF TAOK1 HECW1 CDC42BPB	5.16e-05	493	47	6	15368895
Pubmed	Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2.	OBP2B OBP2A	6.40e-05	9	47	2	15363845
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KIAA1958 ELOA MYOF TAOK1 XPC GPRIN1 PHLDB2	7.63e-05	774	47	7	15302935
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	MYOF L3MBTL2 TRIO CDC42BPB FARP1	8.49e-05	332	47	5	37433992
Pubmed	The interactome of the prostate-specific protein Anoctamin 7.	ELOA TAOK1 XPC	9.53e-05	65	47	3	32176628
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYOF HERC2 TRIO CDC42BPB	1.62e-04	202	47	4	33005030
Pubmed	Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.	AMPH HECW1	1.86e-04	15	47	2	19144635
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	CACNA1S AMPH	2.12e-04	16	47	2	32994313
Pubmed	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.	HERC2 DNAH11	2.40e-04	17	47	2	23502783
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 HERC2 HECW1 TRIO CDC42BPB FARP1 PHLDB2	2.92e-04	963	47	7	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DOCK3 KCNN1 MAP3K10 TAOK1 XPC HERC2 TRIO CDC42BPB	2.96e-04	1285	47	8	35914814
Pubmed	Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".	OBP2B OBP2A	3.01e-04	19	47	2	30782214
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DOCK3 HERC2 HECW1	3.83e-04	104	47	3	9205841
Pubmed	Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.	PRDM9 PRDM14	4.06e-04	22	47	2	19050759
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	AMPH MAOA GPRIN1	4.39e-04	109	47	3	29111324
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	ELOA TAOK1 PRDM7 PRDM14	5.01e-04	272	47	4	18187620
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	LPGAT1 ZCCHC9 CNNM2 HERC2 PHLDB2 DNAJC11	5.13e-04	754	47	6	33060197
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC2 HECW1	5.69e-04	26	47	2	26949039
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	AMPH HERC2 TRIO	5.81e-04	120	47	3	31413325
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 ANKRD13D DOCK3 MYOF HERC2 TRIO CDC42BPB	6.65e-04	1105	47	7	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 MYOF ZCCHC9 XPC HERC2 CDC42BPB FARP1 DNAJC11	8.13e-04	1497	47	8	31527615
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	TAOK1 LOXHD1 HERC2 PRDM14 DNAH11	8.76e-04	552	47	5	10737800
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK2 TAOK1 FARP1	1.31e-03	159	47	3	30581152
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ELOA ZCCHC9 XPC HERC2 L3MBTL2	1.34e-03	608	47	5	36089195
Pubmed	Roles of tau protein in health and disease.	TAOK2 TAOK1	1.35e-03	40	47	2	28386764
Interaction	OBP2B interactions	OBP2B OBP2A	1.46e-05	3	45	2	int:OBP2B
Cytoband	3p21.2	DOCK3 LINC00696	1.73e-04	19	47	2	3p21.2
Cytoband	1q32	LPGAT1 CACNA1S	1.17e-03	49	47	2	1q32
Cytoband	9q34	OBP2B OBP2A	1.42e-03	54	47	2	9q34
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM9 PRDM7 PRDM14	3.37e-06	17	32	3	1197
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 MAP3K10 TAOK1	9.94e-06	24	32	3	654
GeneFamily	Lipocalins	OBP2B OBP2A	5.09e-04	19	32	2	631
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF22 TRIO CNTN5	2.84e-03	161	32	3	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO FARP1	6.07e-03	66	32	2	722
Disease	odorant-binding protein 2b measurement	OBP2B OBP2A	2.17e-05	5	44	2	EFO_0801859
Disease	asthma exacerbation measurement, response to corticosteroid	KCNN1 CNTN5 DNAH11	6.13e-05	51	44	3	EFO_0007614, GO_0031960
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	2.57e-04	16	44	2	DOID:331 (implicated_via_orthology)
Disease	Weight Gain	LPGAT1 STS DNAH11	4.79e-04	102	44	3	C0043094
Disease	hair color	LPGAT1 HERC2 PRDM7 DNAI3	1.18e-03	311	44	4	EFO_0003924
Disease	rosacea severity measurement	HERC2 PRDM7 DNAJC11	1.38e-03	147	44	3	EFO_0009180
Disease	kynurenine measurement	CNTN5 DNAH11	1.55e-03	39	44	2	EFO_0008529
Disease	unipolar depression, bipolar disorder	CNNM2 L3MBTL2 CNTN5	1.64e-03	156	44	3	EFO_0003761, MONDO_0004985
Disease	non-alcoholic fatty liver disease, cirrhosis of liver	FARP1 CNTN5	2.85e-03	53	44	2	EFO_0001422, EFO_0003095
Disease	Metastatic melanoma	MAP3K10 TRIO	2.96e-03	54	44	2	C0278883
Disease	apolipoprotein B measurement	SPC24 MYOF TAOK1 OBP2B DNAH11	2.97e-03	663	44	5	EFO_0004615

Protein segments in the cluster

Peptide	Gene	Start	Entry
GWRSEKMETVSGYEA	ANKRD13D	251	Q6ZTN6
EYWDGLAISVMEVEK	LINC00696	71	Q6ZRV3
VEVTEMQMEEYRGWV	BTNL2	81	Q9UIR0
VWDAYTGLEGTVKDM	DNAH11	1376	Q96DT5
MEQTVDLKDYWESGE	CHRNA2	216	Q15822
VGTEEGEVIYTDWKM	DNAI3	636	Q8IWG1
EPDWYGREDVKMVGE	AMPH	86	P49418
VGYWKDMEQEDTAET	CNTN5	911	O94779
ETATKWSGYMEGAVE	MAOA	436	P21397
TNKYEGWPEVVEMEG	FAM3C	206	Q92520
YGKRGLEMEGWEVVE	DNAJC11	81	Q9NVH1
MEEEEGAVAKEWGTT	MAP3K10	1	Q02779
AGYTVMEWGEDIKAV	LPGAT1	76	Q92604
VYTEGGWFEEGMKLE	L3MBTL2	421	Q969R5
WNEMVKDGEIVYTGT	HERC2	36	O95714
DIKEEVDAGDWIGMY	HECW1	101	Q76N89
MVTETELSWGVYTKE	KCNN1	121	Q92952
KVLYEMTVWTGDVVG	LOXHD1	1551	Q8IVV2
EYGVDVFDVRTMEWV	CDC42BPB	1481	Q9Y5S2
EEEDITGTWYVKAMV	OBP2A	21	Q9NY56
EAVKEYVDIMEWLVG	NUTM1	366	Q86Y26
ISIYFTKEEWAEMGD	PRDM9	31	Q9NQV7
EEEDITGTWYVKAMV	OBP2B	21	Q9NPH6
WYKDGMEVTEEERVS	IGSF22	641	Q8N9C0
MWTPTEEEKYGVVIC	DOCK3	1	Q8IZD9
EEEMEGDYQETWKAT	ELOA	131	Q14241
YMSWITQGEVMDVED	CACNA1S	366	Q13698
PLYGMTIEESEDEWG	FARP1	806	Q9Y4F1
DMVWIVGGSSVYKEA	DHFR	111	P00374
TWEVYGAAMEVEVLG	GPRIN1	921	Q7Z2K8
VINMDETVWTKEYEG	TAS2R30	146	P59541
SEVKTYGDNSVMWEI	PRDM14	291	Q9GZV8
ISIYFTKEEWAEMGD	PRDM7	31	Q9NQW5
GVYGDAVEEMDWSVG	STS	306	P08842
AMDEGQYDGKVDVWS	TAOK1	196	Q7L7X3
AMDEGQYDGKVDVWS	TAOK2	196	Q9UL54
IWMDVIVTGAEGYTH	PHLDB2	1236	Q86SQ0
TTWIYHDGEDTKMIV	CNNM2	231	Q9H8M5
VEDMKVSGVHWGYEE	ZSCAN20	316	P17040
VSKIEWDYECEPGMV	SPC24	146	Q8NBT2
WAKGMSADYEEILDV	ZCCHC9	241	Q8N567
WYKMDDAEVTASGIT	USP17L7	346	P0C7H9
MTYVVGIDSDGWVRD	XPC	566	Q01831
DTYLWEMTSGVEEIP	TRIO	1316	O75962
ARKEATDMGSVWYEE	KIAA1958	656	Q8N8K9
SITGEEMSDIYVKGW	MYOF	1806	Q9NZM1
EMVVYGWSTSQLKEE	MYZAP	86	P0CAP1