Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF487 ZNF527 ZBTB38 TBX4 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 CHD2 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	2.34e-23	1459	108	45	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF487 ZNF527 ZBTB38 TBX4 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 PLSCR2 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	5.84e-23	1412	108	44	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF527 ZBTB38 TBX4 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 CHD2 ZNF226 ZNF227 ZNF112 ZNF232 ZNF850 ZKSCAN5 ZNF595 ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF665 GLI4 ZNF256 ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZFP2 ZNF287 ZNF513 ZNF646	3.15e-20	1244	108	39	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF527 ZBTB38 TBX4 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 CHD2 ZNF226 ZNF227 ZNF112 ZNF232 ZNF850 ZKSCAN5 ZNF595 ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF665 GLI4 ZNF256 ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZFP2 ZNF287 ZNF513 ZNF646	6.68e-20	1271	108	39	GO:0000987
GeneOntologyMolecularFunction	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	B4GALT6 B4GALT5	8.66e-05	3	108	2	GO:0008489
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	2.72e-05	2	108	2	GO:0001988
GeneOntologyBiologicalProcess	positive regulation of heart rate	CHRNA7 ADM5 HRC CHRFAM7A	3.28e-05	35	108	4	GO:0010460
GeneOntologyBiologicalProcess	regulation of heart rate	ANK2 ACE CHRNA7 ADM5 HRC CHRFAM7A	6.05e-05	129	108	6	GO:0002027
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	8.12e-05	3	108	2	GO:0001982
GeneOntologyBiologicalProcess	positive regulation of heart contraction	CHRNA7 ADM5 HRC CHRFAM7A	1.26e-04	49	108	4	GO:0045823
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRNA7 CHRFAM7A	1.62e-04	4	108	2	GO:0060112
GeneOntologyBiologicalProcess	positive regulation of blood circulation	CHRNA7 ADM5 HRC CHRFAM7A	1.71e-04	53	108	4	GO:1903524
GeneOntologyCellularComponent	spine apparatus membrane	CHRNA7 CHRFAM7A	7.91e-05	3	108	2	GO:0098897
MousePheno	abnormal somatosensory cortex morphology	GRIN2B CHRNA7 ELP2 CHRFAM7A	1.57e-05	33	65	4	MP:0000859
MousePheno	airway basal cell hyperplasia	CHRNA7 CHRFAM7A	2.13e-05	2	65	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRNA7 CHRFAM7A	2.13e-05	2	65	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRNA7 CHRFAM7A	2.13e-05	2	65	2	MP:0011113
MousePheno	abnormal parietal lobe morphology	GRIN2B CHRNA7 ELP2 CHRFAM7A	2.51e-05	37	65	4	MP:0000794
MousePheno	decreased locomotor activity	EPC2 FLNC ANK2 ATG2B GRIN2B CHRNA7 CDKL5 FGF23 CLCN1 PTS ZFR2 CHRFAM7A GNS	9.46e-05	829	65	13	MP:0001402
MousePheno	abnormal nicotine-mediated receptor currents	CHRNA7 CHRFAM7A	1.27e-04	4	65	2	MP:0009475
MousePheno	hypoactivity	EPC2 FLNC ANK2 ATG2B CHD2 GRIN2B CHRNA7 CDKL5 FGF23 CLCN1 PTS ZFR2 CHRFAM7A GNS	2.07e-04	1023	65	14	MP:0031392
Domain	zf-C2H2	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	1.06e-32	693	105	42	PF00096
Domain	Znf_C2H2	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 ZFR2 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	1.75e-32	805	105	44	IPR007087
Domain	ZnF_C2H2	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 ZFR2 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	2.05e-32	808	105	44	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	6.01e-32	775	105	43	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	6.69e-32	777	105	43	PS00028
Domain	Znf_C2H2/integrase_DNA-bd	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	2.02e-31	694	105	41	IPR013087
Domain	-	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF513 ZNF646	1.50e-30	679	105	40	3.30.160.60
Domain	Znf_C2H2-like	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 ZFR2 GLI4 ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	2.95e-30	796	105	42	IPR015880
Domain	KRAB	ZNF527 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF17 ZNF263 ZNF37A ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF160 ZNF471 ZNF791 ZNF287	7.15e-30	358	105	32	PS50805
Domain	KRAB	ZNF527 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF17 ZNF263 ZNF37A ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF160 ZNF471 ZNF791 ZNF287	7.15e-30	358	105	32	PF01352
Domain	KRAB	ZNF527 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF17 ZNF263 ZNF37A ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF160 ZNF471 ZNF791 ZNF287	1.89e-29	369	105	32	SM00349
Domain	KRAB	ZNF527 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF17 ZNF263 ZNF37A ZNF436 ZNF256 ZNF814 ZNF552 ZNF470 ZNF160 ZNF471 ZNF791 ZNF287	2.06e-29	370	105	32	IPR001909
Domain	zf-C2H2_6	ZNF527 ZNF613 ZNF184 ZKSCAN8 ZNF227 ZNF850 ZKSCAN5 ZFP37 ZNF546 ZNF250 ZNF16 ZNF17 ZNF532 ZNF256 ZNF814 ZNF160 ZNF791 ZFP2 ZNF646	1.12e-14	314	105	19	PF13912
Domain	SCAN_BOX	ZKSCAN8 ZNF232 ZFP69 ZKSCAN5 ZNF263 ZNF287	8.73e-07	58	105	6	PS50804
Domain	SCAN	ZKSCAN8 ZNF232 ZKSCAN5 ZNF263 ZNF287	1.55e-05	56	105	5	SM00431
Domain	SCAN	ZKSCAN8 ZNF232 ZKSCAN5 ZNF263 ZNF287	1.85e-05	58	105	5	PF02023
Domain	SCAN_dom	ZKSCAN8 ZNF232 ZKSCAN5 ZNF263 ZNF287	1.85e-05	58	105	5	IPR003309
Domain	Retrov_capsid_C	ZKSCAN8 ZNF232 ZKSCAN5 ZNF263 ZNF287	2.01e-05	59	105	5	IPR008916
Domain	Galactosyl_T	B4GALT6 B4GALT5	6.45e-04	7	105	2	IPR003859
Domain	Glyco_transf_7C	B4GALT6 B4GALT5	6.45e-04	7	105	2	PF02709
Domain	Glyco_transf_7N	B4GALT6 B4GALT5	6.45e-04	7	105	2	PF13733
Domain	Galactosyl_T_C	B4GALT6 B4GALT5	6.45e-04	7	105	2	IPR027791
Domain	Galactosyl_T_N	B4GALT6 B4GALT5	6.45e-04	7	105	2	IPR027995
Domain	ZU5	ANK2 UNC5D	1.10e-03	9	105	2	SM00218
Domain	ZU5	ANK2 UNC5D	1.37e-03	10	105	2	PS51145
Domain	ZU5	ANK2 UNC5D	1.99e-03	12	105	2	PF00791
Domain	ZU5_dom	ANK2 UNC5D	1.99e-03	12	105	2	IPR000906
Domain	IGc2	NCAM2 DSCAML1 AMIGO3 BCAM UNC5D CDON	2.13e-03	235	105	6	SM00408
Domain	Ig_sub2	NCAM2 DSCAML1 AMIGO3 BCAM UNC5D CDON	2.13e-03	235	105	6	IPR003598
Domain	FN3	FLNC NCAM2 DSCAML1 CDON EPHA5	3.93e-03	185	105	5	SM00060
Domain	ig	NCAM2 DSCAML1 BCAM UNC5D CDON	4.39e-03	190	105	5	PF00047
Domain	Immunoglobulin	NCAM2 DSCAML1 BCAM UNC5D CDON	4.39e-03	190	105	5	IPR013151
Domain	FN3_dom	FLNC NCAM2 DSCAML1 CDON EPHA5	6.54e-03	209	105	5	IPR003961
Domain	-	CHRNA7 CHRFAM7A	7.33e-03	23	105	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRNA7 CHRFAM7A	7.33e-03	23	105	2	IPR027361
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 GRIN2B ZNF226 ZNF227 ZNF112 ZFP69 ZKSCAN5 ZNF595 ZFP37 ZNF546 ZNF250 ZNF34 ZNF17 ZNF263 ZNF37A ZNF665 ZNF436 ZNF256 ZNF552 ZNF470 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287	2.38e-12	1387	78	31	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF226 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF250 ZNF263 ZNF665 ZNF814 ZNF160 ZFP2	7.51e-07	768	78	17	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF226 ZNF112 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF250 ZNF263 ZNF665 ZNF814 ZNF160 ZFP2	3.40e-05	1022	78	17	MM15436
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF300 ZNF595 ZNF665 ZNF160	2.56e-04	56	78	4	MM17236
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF175 ZNF300 ZNF850 ZNF263 ZNF665 ZNF814 ZNF160 ZFP2 ZNF287	3.85e-14	49	109	9	9630514
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FLNC ZNF184 ZNF189 ZKSCAN8 FBXO11 CHD2 ZNF227 MAGT1 ZNF850 ZFP37 TUFM ZNF587B ZNF250 ZNF16 ZNF263 NKD1 ZNF532 GLI4 ZNF436 NUFIP2 PEX16 ZNF525 BCAM ZNF160 ZNF646	4.07e-14	1203	109	25	29180619
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF184 ZKSCAN8 ZNF227 ZNF595 ZNF587B ZNF250 ZNF34 ZNF17 ZNF552 ZNF160 ZNF791	1.38e-11	181	109	11	37372979
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 ERBB3 ZBTB38 ANK2 ZNF189 FBXO11 NCAM2 ZNF214 GRIN2B ZNF227 HUWE1 LRP1B ZKSCAN5 DSCAML1 ZNF34 ZNF532 OTOF ZNF83 METAP2	1.81e-08	1285	109	19	35914814
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZFP69 ZNF850 ZNF595 ZNF814	4.25e-07	20	109	4	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZFP69 ZNF850 ZNF595 ZNF814	4.25e-07	20	109	4	2542606
Pubmed	Regulation of NMDA receptor trafficking by amyloid-beta.	GRIN2B CHRNA7 CHRFAM7A	1.04e-06	7	109	3	16025111
Pubmed	Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.	ZNF850 ZFP37 ZNF665 ZNF814 ZNF160	1.31e-06	60	109	5	18023262
Pubmed	The DNA sequence and biology of human chromosome 19.	ZNF175 ZNF226 ZNF112 ZNF17 ZNF814 ZNF888 ZNF470 ZNF471	3.34e-06	284	109	8	15057824
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF487 TBX4 ZNF175 ZKSCAN8 ZNF300 ZNF595 ZFP37 ZNF263 ZNF665 ZNF160 ZNF513 ZNF646	9.11e-06	808	109	12	20412781
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	12628457
Pubmed	CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.	GRIN2B CDKL5	9.73e-06	2	109	2	28688852
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	28243714
Pubmed	β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.	B4GALT6 B4GALT5	9.73e-06	2	109	2	23882130
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	21501254
Pubmed	Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.	B4GALT6 B4GALT5	9.73e-06	2	109	2	24498430
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	24326163
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRNA7 CHRFAM7A	9.73e-06	2	109	2	23811428
Interaction	RNF4 interactions	FLNC ZNF184 ZNF189 ZKSCAN8 FBXO11 CHD2 ZNF227 MAGT1 ZNF850 ZFP37 TUFM ZNF587B ZNF250 ZNF16 ZNF263 NKD1 ZNF532 GLI4 ZNF436 NUFIP2 PEX16 ZNF525 BCAM ZNF160 ZNF646	1.02e-07	1412	109	25	int:RNF4
Interaction	TRIM28 interactions	ZNF527 ZNF184 ZKSCAN8 ZNF226 ZNF227 HUWE1 ZNF112 ZNF595 TUFM ZNF587B ZNF250 DAP3 ZNF34 ZNF17 ZNF263 ZNF37A ZNF256 ZNF888 ZNF552 ELP2 ZNF160 ZNF471 ZNF791 METAP2 ZNF287	2.30e-07	1474	109	25	int:TRIM28
Interaction	GLI4 interactions	ZNF184 ZNF189 ZKSCAN8 LRP1B DAP3 GLI4 ZNF791	5.26e-06	125	109	7	int:GLI4
Interaction	ZSCAN21 interactions	ZKSCAN8 ZNF232 LRP1B ZKSCAN5 ZFP37 ZNF287 ZNF513	6.16e-06	128	109	7	int:ZSCAN21
Interaction	LTBP2 interactions	ZNF17 ZNF263 GLI4 NUFIP2 ZNF791 ZNF646	6.74e-06	85	109	6	int:LTBP2
Interaction	ZNF445 interactions	ZKSCAN8 ZNF232 ZNF263 GLI4 ZNF287	1.41e-05	57	109	5	int:ZNF445
Interaction	ZFP3 interactions	ZFP37 YJU2B ZNF287 ZNF513	1.99e-05	30	109	4	int:ZFP3
Interaction	ZNF24 interactions	ZKSCAN8 ZNF232 ZFP37 ZNF263 YJU2B ZNF287 ZNF513	4.51e-05	174	109	7	int:ZNF24
Interaction	ZSCAN23 interactions	ZKSCAN8 ZNF232 ZNF263 YJU2B	5.76e-05	39	109	4	int:ZSCAN23
Interaction	ZKSCAN8 interactions	ZKSCAN8 FBXO11 ZNF232 ZNF263 YJU2B GLI4	7.55e-05	130	109	6	int:ZKSCAN8
Interaction	AGTR2 interactions	ERBB3 ACE ERBIN	9.90e-05	17	109	3	int:AGTR2
Interaction	NOTCH2 interactions	USP53 ZNF189 ZKSCAN8 ZNF587B ZNF263 GLI4 ZNF888 ZNF791 EPHA5 ZNF646	1.00e-04	423	109	10	int:NOTCH2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF527 ZNF613 ZNF175 EML2 ZNF226 ZNF227 ZNF112 ZNF850 ZNF587B ZNF546 ADM5 ZNF17 ZNF665 ZNF256 HRC ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 ZNF83 BCAM ZNF160 ZNF471	7.10e-16	1192	109	24	chr19q13
Cytoband	19q13.43	ZNF256 ZNF814 ZNF552 ZNF470 ZNF471	2.18e-06	87	109	5	19q13.43
Cytoband	19q13.2	ZNF226 ZNF112 ZNF546 BCAM	6.52e-04	164	109	4	19q13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF527 ZBTB38 ZNF613 ZNF175 ZNF184 ZNF189 ZKSCAN8 ZNF300 ZNF214 ZNF226 ZNF227 ZNF112 ZNF232 ZFP69 ZNF850 ZKSCAN5 ZNF595 ZFP37 ZNF587B ZNF546 ZNF250 ZNF34 ZNF16 ZNF17 ZNF263 ZNF37A ZNF532 ZNF665 GLI4 ZNF436 ZNF256 ZNF814 ZNF888 ZNF552 ZNF525 ZNF470 ZNF83 ZNF160 ZNF471 ZNF791 ZFP2 ZNF287 ZNF513 ZNF646	6.01e-38	718	89	44	28
Coexpression	GSE15750_WT_VS_TRAF6KO_DAY6_EFF_CD8_TCELL_UP	ERBB3 ZFP69 TUFM DAP3 CLCN1 YJU2B SPAG16 GNS	1.83e-06	200	108	8	M3570
Coexpression	GSE18893_TCONV_VS_TREG_2H_TNF_STIM_DN	TET2 CCPG1 ZNF189 FBXO11 ZNF226 ERBIN PNRC1	1.62e-05	194	108	7	M7306
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	ZNF487 ERBB3 DTNA CHD2 ZNF587B ZNF250 CFLAR CDKL5 PNRC1 BCAM ZNF160 METAP2 CDON	2.83e-05	807	108	13	M16651
ToppCell	10x3'2.3-week_12-13-Myeloid_DC-DC-DC1\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ERBB3 ZNF587B ZNF250 CDKL5 FAM83G ZNF470	4.04e-06	171	109	6	04346d4eb726875e3537e215ea081a0318ca4ddd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAM2 GRIN2B LRP1B DSCAML1 UNC5D EPHA5	6.16e-06	184	109	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAM2 GRIN2B LRP1B DSCAML1 UNC5D EPHA5	6.16e-06	184	109	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAM2 GRIN2B LRP1B DSCAML1 UNC5D EPHA5	6.16e-06	184	109	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgA_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CCPG1 ZBTB38 FBXO11 FGF23 PNRC1 ZNF791	7.18e-06	189	109	6	a0634d72bfdd5f93877724ed6480b50a3a046f71
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNC ERBB3 DTNA OTOF HRC BCAM	8.58e-06	195	109	6	80b973d2a23ef9b101c90e1635e68c9a3f78f65d
Disease	lung non-small cell carcinoma (is_implicated_in)	TET2 ERBB3 FBXO11 LRP1B CHRNA7	1.19e-04	139	101	5	DOID:3908 (is_implicated_in)
Disease	cognitive disorder (implicated_via_orthology)	CHRNA7 CHRFAM7A	1.72e-04	6	101	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRNA7 CHRFAM7A	1.72e-04	6	101	2	DOID:7148 (biomarker_via_orthology)
Disease	Neurodevelopmental Disorders	ANK2 CHD2 GRIN2B CDKL5	2.99e-04	93	101	4	C1535926
Disease	pneumonia, COVID-19	GRIN2B LRP1B METAP2 UNC5D	6.26e-04	113	101	4	EFO_0003106, MONDO_0100096
Disease	Colorectal Carcinoma	TET2 FLNC ANK2 EML2 ZNF232 DSCAML1 CDKL5 ADAMTS18 ZNF471	6.92e-04	702	101	9	C0009402
Disease	nicotine dependence (implicated_via_orthology)	CHRNA7 CHRFAM7A	7.49e-04	12	101	2	DOID:0050742 (implicated_via_orthology)
Disease	Mental Retardation, X-Linked Nonsyndromic	HUWE1 PTCHD1	8.83e-04	13	101	2	C3501611
Disease	severe acute respiratory syndrome, COVID-19	NCAM2 LRP1B B4GALT5 ZNF665 USP12 ELP2 ZNF83	8.84e-04	447	101	7	EFO_0000694, MONDO_0100096
Disease	atrial fibrillation (is_implicated_in)	ANK2 ACE	1.03e-03	14	101	2	DOID:0060224 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ACE LRP1B CHRNA7	1.33e-03	63	101	3	DOID:3083 (is_implicated_in)
Disease	response to triptolide, cytotoxicity measurement	CFLAR ZNF532	1.35e-03	16	101	2	EFO_0006952, EFO_0007662
Disease	stomach cancer (is_implicated_in)	TET2 ACE LRP1B	1.96e-03	72	101	3	DOID:10534 (is_implicated_in)
Disease	lung cancer (is_implicated_in)	ACE LRP1B CHRNA7	2.12e-03	74	101	3	DOID:1324 (is_implicated_in)
Disease	Epilepsy, Cryptogenic	CHD2 GRIN2B CDKL5	2.83e-03	82	101	3	C0086237
Disease	Awakening Epilepsy	CHD2 GRIN2B CDKL5	2.83e-03	82	101	3	C0751111
Disease	Aura	CHD2 GRIN2B CDKL5	2.83e-03	82	101	3	C0236018
Disease	West Syndrome	GRIN2B CDKL5	3.05e-03	24	101	2	C0037769
Disease	Autism Spectrum Disorders	CHD2 GRIN2B PTCHD1	3.14e-03	85	101	3	C1510586
Disease	beta-amyloid 1-42 measurement	GRIN2B ERBIN ADAMTS18	3.35e-03	87	101	3	EFO_0004670

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTGLHHYNPSIHRDQ	nan	16	Q9HAA7
QGPGHQAPHVHYARL	ERBB3	1296	P21860
AYHLHQRLGPARHGE	ERBIN	1041	Q96RT1
YATPATLHNGNHHKV	EPC2	296	Q52LR7
RGQHQVPQHRGHVCY	ADM5	26	C9JUS6
HRHYGAQHINLEGPI	ACE	861	P12821
HFHNGHIKLPGVRTY	EPHA5	636	P54756
PTHREEEYGKNHHNS	FLG	166	P20930
GPRLHHNQTHEYNVS	AMIGO3	356	Q86WK7
HGHYPNTIAEKHGFR	PIK3AP1	371	Q6ZUJ8
TGKYKSIPHHHRGEV	B4GALT5	321	O43286
VYGVDQTHSGLPLHH	CFLAR	321	O15519
QLHYKHSENRGPQGN	ATG2B	646	Q96BY7
HLVPQHGVCNHKFYG	ADAMTS18	1196	Q8TE60
TVIVLQYHHHDPDGG	CHRNA7	311	P36544
YESQAGQPVQRHEHH	NKD1	441	Q969G9
GYTPLHQAAQQGHTH	ANK2	761	Q01484
RELNHPFGLSHHGNY	LRP1B	736	Q9NZR2
HSIGQYRIHAGKTVP	METAP2	331	P50579
HKNPHTGHVNYIHGS	MAGT1	246	Q9H0U3
GPSHENIITHGRKYH	MEPE	456	Q9NQ76
YPKHQAGHTGKQADH	PLSCR2	21	Q9NRY7
HGQLVHGIHLYEQPK	PNRC1	196	Q12796
HTVAVKYRGQHVPGS	FLNC	2286	Q14315
YVRDKPHVNVGTIGH	TUFM	51	P49411
NTGHTIHVHYPGNRQ	HUWE1	2556	Q7Z6Z7
TVIVLQYHHHDPDGG	CHRFAM7A	221	Q494W8
LEQHHYIPHVVLGKG	OSGIN2	111	Q9Y236
HPQYKAPTENHHNRG	CCPG1	571	Q9ULG6
GKYKSIPHHHRGEVQ	B4GALT6	316	Q9UBX8
PKIHQHTSYVGEQHL	C4orf45	31	Q96LM5
MHGHPRDNYNHPNKR	CHD2	1616	O14647
EIHHGQTGGIYVHEK	FBXO11	496	Q86XK2
HNKIHDGQHGGIYVH	FBXO11	586	Q86XK2
DIYDVPHIRHVHANG	DSCAML1	66	Q8TD84
YHLQIHKNGHVDGAP	FGF23	51	Q9GZV9
HKNGHVDGAPHQTIY	FGF23	56	Q9GZV9
YSHLHHKVPNAVNGI	CDON	1046	Q4KMG0
FIQHHRIHTGEKPYE	GLI4	226	P10075
GKYPHNHHVVNNTLE	GNS	101	P15586
AQIHARKPGYIHSGA	DTNA	671	Q9Y4J8
QPRALSHKYGGHSSH	EML2	606	O95834
VHLQGHEGPVYAVHA	ELP2	101	Q6IA86
NPHGNKRHVFHFGTV	BCAM	526	P50895
HTRQKSEGGVYHDPH	CDKL5	676	O76039
VGTVYSQPEHQFHHK	OTOF	341	Q9HC10
KEAQGQQFHHHRVPA	FAM83G	691	A6ND36
DHSPGNHEQSYVGKR	PEX16	156	Q9Y5Y5
PAKHGDQHEGQHYNI	DAP3	56	P51398
HSHRHLYPEGIGARQ	POMT2	356	Q9UKY4
PITHLKDGRAVYNGH	PTCHD1	176	Q96NR3
QFGHYVASHQPRGHK	HRC	386	P23327
YTPLHLAAIHGHQGV	SOWAHB	671	A6NEL2
GPRHNVHPTQIYGHH	CLCN1	51	P35523
VHPTQIYGHHKEQFS	CLCN1	56	P35523
QHGNPHLYHSQGKGS	USP53	501	Q70EK8
HLANHRRIHTGEKPY	ZNF665	416	Q9H7R5
GSTEQYDHRHAGNKP	ZNF525	121	Q8N782
HTRHQRTHTGGKPYE	ZNF37A	286	P17032
NYKRHQKVHGHGGAG	ZNF513	486	Q8N8E2
AHFIQHQRVHTGEKP	ZNF189	161	O75820
HSHAYTQHPGIKIGE	ZNF532	886	Q9HCE3
HLTQHTGIHAGEKPY	ZNF595	186	Q8IYB9
HLANHQRTHTGEKPY	ZNF160	691	Q9HCG1
YHQPFQRHERTHIGE	ZNF791	171	Q3KP31
AGPQTYREHLGGQKH	ZFR2	281	Q9UPR6
HLIQHQRTHSGEKPY	ZNF436	236	Q9C0F3
VLIQHHNVHTGEKPY	ZNF250	381	P15622
NLTQHHRTHTGEKPY	ZNF287	606	Q9HBT7
HQQPHQYLQHGAEGS	NUFIP2	51	Q7Z417
SHGGVPIHHYQVDVK	NCAM2	521	O15394
VEHQGTHHGQKLYTD	ZNF256	106	Q9Y2P7
QRGHSYHGPQIKVDH	SPAG16	266	Q8N0X2
QGHHVRPIEKAAIHY	TRIM75	126	A6NK02
YHLTEHQRIHSGVKP	ZNF546	286	Q86UE3
HGSYLVQHQKIHTGE	ZNF546	396	Q86UE3
SGPNRGHYIAIVKSH	USP12	311	O75317
YRHGGSLVNHRKIHQ	ZNF646	1061	O15015
HLAQHQRVHTGEKPY	ZNF470	326	Q6ECI4
HLVQHQRVHTGEKPY	ZNF470	551	Q6ECI4
VIGTNNIHGRYPHTK	TMPRSS12	136	Q86WS5
GVSHNFQVRDHPLYH	TTC21A	561	Q8NDW8
NPEKHGSLNRYHNSH	YJU2B	16	P13994
YHGKNHSRTFPHGNN	UNC5D	501	Q6UXZ4
SHYQVHLVVHTGEKP	ZNF226	516	Q9NYT6
HQHQNEHIGEKPYRG	ZNF587B	136	E7ETH6
LARHHRVHTGEKPYQ	ZNF888	341	P0CJ79
SHNLYLQGHPKIHIG	ZNF112	481	Q9UJU3
HLIQHQRIHTGEKPY	ZNF471	276	Q9BX82
QHQNEHIGEKPYRGS	ZNF552	136	Q9H707
YHQRVHTGEKPHGCS	ZNF613	221	Q6PF04
GLTEHQRNHTGEKPY	ZNF613	246	Q6PF04
QHQGVHTGDKPYACH	ZNF16	506	P17020
GLQSHQRVHTGEKPY	ZNF227	646	Q86WZ6
HLVQHQRIHSGEKPY	ZNF232	346	Q9UNY5
GPLLGTHQALQHYQH	TBX4	291	P57082
NHEQRHIREHNGKGY	ZBTB38	1111	Q8NAP3
HLIVHQRSHTGEKPY	ZFP2	256	Q6ZN57
LNGGVLEEHHHYPNQ	TET2	426	Q6N021
GLTQHQRVHTGEKPY	ZFP37	531	Q9Y6Q3
PNGHGHNYKVVVTVH	PTS	46	Q03393
HLVVHQRTHTGEKPY	ZNF300	311	Q96RE9
LIQHQRIHTGEKPYH	ZNF850	576	A8MQ14
HLVGHQKIHTGERPY	ZNF17	316	P17021
LHIHQRVHTGEKPYQ	ZNF214	541	Q9UL59
HQHQNEHIGEKPYRG	ZNF814	136	B7Z6K7
HLTQHQRIHTGEKPY	ZNF184	656	Q99676
HLIVHQRSHTGEKPY	ZNF175	461	Q9Y473
HLTQHQRVHTGEKPY	ZKSCAN5	591	Q9Y2L8
HLAQHQRIHTGEKPY	ZNF83	191	P51522
HLIGHQRSHTGEKPY	ZKSCAN8	476	Q15776
LHVHQRTHTGEKPYG	ZNF487	301	B1APH4
HLIQHQRIHTGEKPY	ZNF34	461	Q8IZ26
SLNQHHRTHTGEKPY	ZFP69	341	Q49AA0
HLNQHQRIHTGEKPY	ZNF527	456	Q8NB42
NLHRHQRTHTGEKPY	ZNF263	476	O14978
HHHHNNPGGGYMLSK	GRIN2B	1361	Q13224