Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	sperm midpiece	ATP1A4 PCDH11Y VPS13A	7.60e-05	64	27	3	GO:0097225
Domain	Protein_kinase_ATP_BS	PRKACG PTK2B PDIK1L	1.69e-02	379	27	3	IPR017441
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PRKACG RYR2	4.10e-05	12	28	2	10830164
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MRPS15 PDIK1L GCC2 NEMF ALG13	4.33e-05	496	28	5	31343991
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RBM27 GCC2 VAT1 ALG13 VPS13A	8.22e-05	568	28	5	37774976
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CHD6 GCC2 RYR2 LPO VPS13A	1.42e-04	638	28	5	31182584
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	MRPS15 GTPBP4 NEMF	1.71e-04	134	28	3	28695742
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MRPS15 GTPBP4 CHD6 RPL14 RBM27 NEMF	1.87e-04	1082	28	6	38697112
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	MRPS15 RPL14 LRRIQ1 RBM27 NEMF VAT1	2.59e-04	1149	28	6	35446349
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	MRPS15 GTPBP4 CHD6 RPL14 ATP1A4 RBM27	2.64e-04	1153	28	6	29845934
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	CCDC168 RYR2 CCDC93	3.32e-04	168	28	3	30631154
Pubmed	Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.	PTK2B RPL14	3.87e-04	36	28	2	15717329
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	GTPBP4 RPL14 RBM27	4.19e-04	182	28	3	32239614
Pubmed	GRSF1 regulates RNA processing in mitochondrial RNA granules.	MRPS15 RPL14	4.55e-04	39	28	2	23473034
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	MRPS15 MCC GTPBP4 RPL14 CCDC93	5.22e-04	847	28	5	35235311
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	GTPBP4 RPL14 RBM27 ALG13	5.77e-04	483	28	4	36912080
Pubmed	Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.	GTPBP4 RPL14	6.33e-04	46	28	2	32669547
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	MRPS15 GTPBP4 RPL14	7.28e-04	220	28	3	34091597
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	PRKACG TMC1 VPS13A	2.43e-04	199	28	3	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q22	SKA2 LPO	1.33e-03	88	28	2	chr17q22
GeneFamily	EF-hand domain containing	MCC RYR2	1.21e-02	219	14	2	863
Coexpression	GSE24292_WT_VS_PPARG_KO_MACROPHAGE_DN	MRPS15 GTPBP4 PTK2B GCC2 ITGB3BP	1.73e-06	200	27	5	M8054
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	MRPS15 MCC RBM27 CCDC93 NEMF VAT1	3.08e-06	408	27	6	M11891
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	MRPS15 MCC RBM27 CCDC93 NEMF VAT1	3.39e-06	415	27	6	MM1028
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTK2B LRRIQ1 RYR2 VPS13A	5.36e-06	186	28	4	84ba666237c18189d7e7556bd92dd953af733c00
Disease	occupational attainment	SKA2 ZSWIM6	7.30e-04	42	28	2	EFO_0020977
Disease	alcohol use disorder (implicated_via_orthology)	PRKACG ATP1A4 RYR2	8.24e-04	195	28	3	DOID:1574 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	CHD6 RPL14	1.96e-03	69	28	2	DOID:1682 (implicated_via_orthology)
Disease	Autism Spectrum Disorders	RYR2 NEMF	2.95e-03	85	28	2	C1510586
Disease	emphysema imaging measurement	MCC PDIK1L	8.45e-03	146	28	2	EFO_0007626
Disease	myeloid white cell count	MCC PTK2B ATP1A4 VAT1	1.13e-02	937	28	4	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLIKINIMNMNKQSK	AGBL5	86	Q8NDL9
MDIKQQKKMFKKIRG	ALG13	581	Q9NP73
VKKAKTMMKNAQKKM	GTPBP4	586	Q9BZE4
QKMLISKLEKNKNMK	RBM27	841	Q9P2N5
QPMKRGQKSKMKKMK	NEMF	866	O60524
LLAKKSKLMKQNKMM	LPO	516	P22079
RNKEVINIMKKIMKK	OR5K3	291	A6NET4
QMLKRAQKMKSKKLK	LRRIQ1	1556	Q96JM4
MQKTKELMTKVNKQK	ITGB3BP	136	Q13352
KQSRMKMEKKKQENK	CCDC93	571	Q567U6
KKHQNKLKKLESQMM	MCC	781	P23508
AMKILNKQKVVKMKQ	PRKACG	71	P22612
MKMKIQKKEKQLSNL	CHD6	1	Q8TD26
IKFAKKQMMLIQKAK	GCC2	31	Q8IWJ2
QRQKMEKIRALKKMK	CCDC168	4041	Q8NDH2
KVKMRQILDKQQKQM	PTK2B	801	Q14289
KQMKKVKKMTVKDMV	RYR2	4266	Q92736
PENRQMIMMKKKKKK	PCDH11Y	891	Q9BZA8
KEMLKIKQEQFMKKI	MRPS15	101	P82914
TVKKTMNMIQKLQKQ	SKA2	81	Q8WVK7
KKKSMNGRMKQLIKE	PDIK1L	296	Q8N165
KKKMKMQALENKMRN	TMC1	731	Q8TDI8
IKKKMVKREKQKRNM	ATP1A4	26	Q13733
NLGIKMKKKAKMAIV	VPS13A	1801	Q96RL7
KVMKAKKMRNRIIKN	RPL14	111	P50914
MKQMQEKKNVGKVLL	VAT1	371	Q99536
LKQIYKGKKKLMMLV	ZSWIM6	1196	Q9HCJ5
SQIKRQMMLKMKLKK	ZNF518B	1001	Q9C0D4
QMMLKMKLKKVHKNN	ZNF518B	1006	Q9C0D4