Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

1.50e-1511413515GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

5.44e-1512413515GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

2.46e-1413713515GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

3.59e-1219213515GO:0008234
GeneOntologyMolecularFunctionmicrotubule minus-end binding

CEP290 NUMA1 TUBGCP2 MACF1 NIN

3.73e-08151355GO:0051011
GeneOntologyMolecularFunctionpeptidase activity

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 MEP1A USP17L17 USP40 USP17L3 USP17L22 USP17L15

9.06e-0665413516GO:0008233
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

CYLC2 ANK3 SPTAN1 SPTB TLN1 MYOM2

2.57e-041301356GO:0005200
GeneOntologyMolecularFunctionmicrotubule plus-end binding

CLIP2 NUMA1 CLIP1

4.24e-04221353GO:0051010
GeneOntologyMolecularFunctioncytoskeletal protein binding

LIMA1 ANK3 CLIP2 VEZT MYO9A SPTAN1 SPTB CEP290 NUMA1 TUBGCP2 CLIP1 CEP350 TLN1 SYNE2 MACF1 MYH15 UTRN NIN

4.40e-04109913518GO:0008092
GeneOntologyMolecularFunctionNAD+-protein-cysteine ADP-ribosyltransferase activity

TIPARP PARP6

6.69e-0461352GO:0140803
GeneOntologyMolecularFunctionNAD+-protein poly-ADP-ribosyltransferase activity

TIPARP PARP6 ART3

8.75e-04281353GO:0003950
GeneOntologyMolecularFunctionactin filament binding

LIMA1 MYO9A SPTAN1 SPTB TLN1 MACF1 MYH15

9.05e-042271357GO:0051015
GeneOntologyMolecularFunctionATP-dependent activity

ATP6V1C1 ATP8B4 ABCA4 MYO9A ABCA13 ATAD5 MORC4 RAD50 DNAH17 MACF1 MYH15 ATP1B2

9.53e-0461413512GO:0140657
GeneOntologyMolecularFunctionNAD+-protein ADP-ribosyltransferase activity

TIPARP PARP6 ART3

1.07e-03301353GO:1990404
GeneOntologyMolecularFunctionmicrotubule binding

CLIP2 CEP290 NUMA1 TUBGCP2 CLIP1 CEP350 MACF1 NIN

1.19e-033081358GO:0008017
GeneOntologyMolecularFunctionphosphorylation-dependent protein binding

ANK3 NBN

1.97e-03101352GO:0140031
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

4.31e-1512513615GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22 USP17L15

3.65e-1414413615GO:0070646
GeneOntologyBiologicalProcesspost-translational protein modification

USP17L21 USP17L12 USP17L1 TRIM4 RPS6KA5 MYCBP2 USP17L20 USP17L11 USP17L24 USP17L5 NBN USP17L10 USP17L19 KIAA1586 USP17L18 PARP6 USP17L17 USP40 USP17L3 UBE2QL1 USP17L22 USP17L15

2.06e-06107413622GO:0043687
GeneOntologyBiologicalProcessvesicle cargo loading

CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4

3.70e-06361365GO:0035459
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP17L21 USP17L12 USP17L1 TRIM4 MYCBP2 USP17L20 USP17L11 USP17L24 USP17L5 NBN USP17L10 USP17L19 KIAA1586 USP17L18 USP17L17 USP40 USP17L3 UBE2QL1 USP17L22 USP17L15

1.03e-05100913620GO:0070647
GeneOntologyBiologicalProcessGolgi vesicle transport

CTAGE9 ANK3 CTAGE6 RAB34 RABEP1 CTAGE8 TRAPPC10 CTAGE15 MACF1 CTAGE4 GOLGA4

1.57e-0533913611GO:0048193
GeneOntologyBiologicalProcessmicrotubule-based process

ADCY10 ENKUR ANK3 CLIP2 CEP290 NUMA1 FYCO1 TUBGCP2 CLIP1 CEP350 DNAH17 SYNE2 SLC9B2 FER MACF1 CFAP69 INVS PCNT NIN

6.69e-05105813619GO:0007017
GeneOntologyBiologicalProcessGolgi to plasma membrane transport

ANK3 RAB34 RABEP1 MACF1 GOLGA4

9.93e-05701365GO:0006893
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

CTAGE9 USP17L21 CALR3 DPY19L3 USP17L12 PTCHD3 USP17L1 USP17L20 USP17L11 ERO1A GRAMD1A USP17L5 USP17L10 CTAGE6 USP17L19 FADS2B USP17L18 PARP6 POM121 USP17L17 SYNE2 CTAGE8 USP17L3 CTAGE15 CTAGE4 USP17L22 USP17L15

9.04e-08129913827GO:0098827
GeneOntologyCellularComponentendoplasmic reticulum membrane

CTAGE9 USP17L21 CALR3 DPY19L3 USP17L12 PTCHD3 USP17L1 USP17L20 USP17L11 ERO1A GRAMD1A USP17L5 USP17L10 CTAGE6 USP17L19 FADS2B USP17L18 POM121 USP17L17 SYNE2 CTAGE8 USP17L3 CTAGE15 CTAGE4 USP17L22 USP17L15

3.10e-07129313826GO:0005789
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

CTAGE9 USP17L21 CALR3 DPY19L3 USP17L12 PTCHD3 USP17L1 USP17L20 USP17L11 ERO1A GRAMD1A USP17L5 USP17L10 CTAGE6 USP17L19 FADS2B USP17L18 POM121 USP17L17 SYNE2 CTAGE8 USP17L3 CTAGE15 CTAGE4 USP17L22 USP17L15

5.10e-07132713826GO:0042175
GeneOntologyCellularComponentcytoplasmic microtubule

ENKUR RPGRIP1L CLIP2 NUMA1 RIBC1 TUBGCP2 CLIP1 NIN

2.88e-061331388GO:0005881
GeneOntologyCellularComponentendoplasmic reticulum exit site

CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4

8.15e-06421385GO:0070971
GeneOntologyCellularComponentmicrotubule

ENKUR RPGRIP1L CLIP2 NUMA1 RIBC1 TUBGCP2 BOD1L2 CLIP1 DNAH17 MACF1 INVS PCNT NIN

5.38e-0553313813GO:0005874
GeneOntologyCellularComponentcilium

ADCY10 ENKUR ABCA4 RPGRIP1L PTCHD3 CEP290 RIBC1 EVC TBC1D31 RAB34 DNAH17 SLC9B2 CABCOCO1 CFAP69 INVS PCNT NIN

9.06e-0589813817GO:0005929
GeneOntologyCellularComponentsupramolecular fiber

ENKUR EPPK1 RPGRIP1L ANK3 CLIP2 MYO9A SPTAN1 NUMA1 RIBC1 TUBGCP2 BOD1L2 CLIP1 DNAH17 SYNE2 MACF1 MYH15 MYOM2 INVS PCNT NIN

9.51e-05117913820GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

ENKUR EPPK1 RPGRIP1L ANK3 CLIP2 MYO9A SPTAN1 NUMA1 RIBC1 TUBGCP2 BOD1L2 CLIP1 DNAH17 SYNE2 MACF1 MYH15 MYOM2 INVS PCNT NIN

1.04e-04118713820GO:0099081
GeneOntologyCellularComponentmicrotubule organizing center

RPGRIP1L CEP290 NUMA1 EVC TUBGCP2 ECPAS BOD1L2 HNMT CLIP1 CEP350 TBC1D31 RAB34 CEP112 CAPRIN2 CABCOCO1 PCNT NIN

1.20e-0491913817GO:0005815
GeneOntologyCellularComponentcentrosome

RPGRIP1L CEP290 NUMA1 TUBGCP2 ECPAS BOD1L2 HNMT CLIP1 CEP350 TBC1D31 CEP112 CAPRIN2 CABCOCO1 PCNT NIN

1.77e-0477013815GO:0005813
GeneOntologyCellularComponentMre11 complex

NBN RAD50

4.27e-0451382GO:0030870
GeneOntologyCellularComponentcell projection membrane

LIMA1 VEZT DOCK8 EVC RAB34 TLN1 SYNE2 MACF1 ATP1B2 UTRN

5.93e-0443113810GO:0031253
GeneOntologyCellularComponentBRCA1-C complex

NBN RAD50

6.38e-0461382GO:0070533
GeneOntologyCellularComponentmicrotubule plus-end

CLIP2 NUMA1 CLIP1

8.17e-04281383GO:0035371
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

ENKUR EPPK1 RPGRIP1L CLIP2 MYO9A NUMA1 RIBC1 TUBGCP2 BOD1L2 CLIP1 DNAH17 MACF1 INVS PCNT NIN

8.94e-0489913815GO:0099513
GeneOntologyCellularComponentspectrin-associated cytoskeleton

ANK3 SPTB

1.51e-0391382GO:0014731
GeneOntologyCellularComponentspectrin

SPTAN1 SPTB

1.51e-0391382GO:0008091
GeneOntologyCellularComponentmicrotubule end

CLIP2 NUMA1 CLIP1

2.01e-03381383GO:1990752
GeneOntologyCellularComponentmotile cilium

ADCY10 ENKUR PTCHD3 DNAH17 SLC9B2 CABCOCO1 CFAP69 PCNT

2.51e-033551388GO:0031514
GeneOntologyCellularComponentastrocyte end-foot

ADCY10 ATP1B2

2.73e-03121382GO:0097450
GeneOntologyCellularComponentleading edge membrane

VEZT DOCK8 RAB34 TLN1 SYNE2 MACF1

2.74e-032101386GO:0031256
GeneOntologyCellularComponentlateral plasma membrane

ANK3 SPTAN1 NUMA1 ATP1B2

3.00e-03901384GO:0016328
GeneOntologyCellularComponentsperm flagellum

ENKUR PTCHD3 DNAH17 SLC9B2 CABCOCO1 CFAP69

3.01e-032141386GO:0036126
DomainHABP4_PAI-RBP1

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22

4.68e-211612911PF04774
DomainHABP4_PAIRBP1-bd

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22

4.68e-211612911IPR006861
DomainUSP_CS

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

1.56e-176612914IPR018200
DomainUCH

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

4.71e-177112914PF00443
DomainUSP_2

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

4.71e-177112914PS00973
DomainUSP_3

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

5.81e-177212914PS50235
DomainUSP_dom

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

5.81e-177212914IPR028889
DomainPeptidase_C19_UCH

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

5.81e-177212914IPR001394
DomainUSP_1

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP40 USP17L3 USP17L22

1.49e-157012913PS00972
DomainSpectrin

SPTAN1 SPTB SYNE2 MACF1 UTRN

4.43e-07231295PF00435
DomainSpectrin_repeat

SPTAN1 SPTB SYNE2 MACF1 UTRN

1.51e-06291295IPR002017
DomainSPEC

SPTAN1 SPTB SYNE2 MACF1 UTRN

2.52e-06321295SM00150
DomainSpectrin/alpha-actinin

SPTAN1 SPTB SYNE2 MACF1 UTRN

2.52e-06321295IPR018159
DomainACTININ_2

SPTB SYNE2 MACF1 UTRN

1.74e-05231294PS00020
DomainACTININ_1

SPTB SYNE2 MACF1 UTRN

1.74e-05231294PS00019
DomainActinin_actin-bd_CS

SPTB SYNE2 MACF1 UTRN

1.74e-05231294IPR001589
DomainCAP_GLY

CLIP2 CLIP1 CEP350

3.73e-05101293PF01302
DomainCAP_GLY

CLIP2 CLIP1 CEP350

3.73e-05101293SM01052
Domain-

CLIP2 CLIP1 CEP350

3.73e-051012932.30.30.190
DomainCAP_GLY_1

CLIP2 CLIP1 CEP350

3.73e-05101293PS00845
DomainCAP_GLY_2

CLIP2 CLIP1 CEP350

3.73e-05101293PS50245
DomainCAP-Gly_domain

CLIP2 CLIP1 CEP350

3.73e-05101293IPR000938
DomainWGR_domain

TIPARP PARP6 ART3

5.86e-04241293IPR008893
Domain-

EPPK1 MACF1

6.97e-04612923.90.1290.10
DomainPlectin

EPPK1 MACF1

9.72e-0471292PF00681
DomainPlectin_repeat

EPPK1 MACF1

9.72e-0471292IPR001101
DomainPLEC

EPPK1 MACF1

9.72e-0471292SM00250
DomainCH

SPTB SYNE2 MACF1 UTRN

1.06e-03651294SM00033
DomainCH

SPTB SYNE2 MACF1 UTRN

1.40e-03701294PF00307
Domain-

SPTB SYNE2 MACF1 UTRN

1.48e-037112941.10.418.10
DomainCH

SPTB SYNE2 MACF1 UTRN

1.64e-03731294PS50021
DomainCH-domain

SPTB SYNE2 MACF1 UTRN

1.81e-03751294IPR001715
PathwayREACTOME_RAS_PROCESSING

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

2.71e-18459913MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

4.21e-102219914M27578
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 SPTAN1 SPTB USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 TLN1 USP17L3 USP17L22 USP17L15

6.43e-103189916MM15278
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.70e-101919913MM15289
PathwayREACTOME_DEUBIQUITINATION

USP17L21 USP17L12 USP17L1 TRIM4 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

2.42e-092999915M27574
PathwayREACTOME_DEUBIQUITINATION

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

3.50e-082629913MM15286
PathwayWP_JOUBERT_SYNDROME

RPGRIP1L CEP290 RAD50 INVS PCNT NIN

1.51e-0576996M39835
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L21 USP17L12 ANK3 USP17L1 TRIM4 USP17L20 USP17L11 SPTAN1 SPTB USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 ST6GAL2 POM121 RAB34 ART3 USP17L17 USP17L3 TRAPPC10 PRKDC USP17L22 USP17L15 GOLGB1

2.17e-0514759925M19806
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

CTAGE9 USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 SPTAN1 SPTB USP17L5 USP17L10 USP17L19 USP17L18 ST6GAL2 POM121 RAB34 ART3 USP17L17 CTAGE8 USP17L3 TRAPPC10 PRKDC USP17L22 USP17L15 GOLGB1

2.42e-0513899924MM15307
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-2721139138622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-27211391314583620
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-27211391311468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-2721139138756639
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-27211391312447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.39e-27211391318980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.80e-2622139139154835
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

8.97e-2624139138995226
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.04e-25331391420228807
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391420403174
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391417109758
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391420388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391414699124
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391420715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-2534139149806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391420368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391415780755
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391419188362
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391411941478
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391410936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.76e-25341391421448158
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.86e-25251391321115691
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

2.92e-25351391416611142
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

2.92e-25351391421239494
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

3.71e-25261391335816173
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

4.77e-25361391420147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

7.64e-25371391420228808
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

2.40e-24291391332527007
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.17e-20501391331806660
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

ADCY10 EPPK1 MYO9A ABCA13 FYCO1 CLIP1 RAD50 CEP112 TLN1 CAPRIN2 FAR1 GOLGB1

5.22e-112081391233230847
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CYLC2 LIMA1 ZNF658 SPTAN1 TAF1B NUMA1 CTAGE6 PCF11 NOP14 TBC1D31 CEP112 SNX25 ARHGAP12 SYNE2 CTAGE8 CAPRIN2 CTAGE15 MACF1 MYH15 MYOM2 PRKDC CTAGE4 CFAP69 GOLGB1 PCNT

5.83e-1014421392535575683
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ARMT1 RPGRIP1L ANK3 MYCBP2 VEZT ATAD5 SPTAN1 GRAMD1A CEP290 NBN CEP350 PCF11 NUDT12 NOP14 TBC1D31 SMG7 SYNE2 UTRN GOLGA4 PCNT NIN

1.33e-0910491392127880917
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

LIMA1 ERO1A SPTAN1 SPTB NUMA1 RABEP1 TLN1 MACF1 PRKDC UTRN GOLGA4 GOLGB1 PCNT

2.54e-093601391333111431
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

SUPT20H MYCBP2 ATAD5 SPTAN1 PARG CEP290 NBN ARHGAP11A WTAP RAD50 CEP350 TBC1D31 TLN1 UTRN PCNT NIN

7.49e-096451391625281560
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

RPGRIP1L CEP290 TUBGCP2 CLIP1 CEP350 TBC1D31 CEP112 PCNT NIN

8.14e-09146139921399614
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EPPK1 MYCBP2 SPTAN1 TUT7 NUMA1 FRYL ECPAS RAD50 NOP14 TLN1 SYNE2 MACF1 SCAF11 PRKDC UTRN PCNT

8.90e-096531391622586326
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ANK3 MYCBP2 VEZT TSHZ2 MYO9A SPTB EVC FRYL ECPAS ZNF248 ZNF33A ZNF33B SMG7 RABEP1 USP40 MACF1 SCAF11 CFAP69 UTRN GOLGA4 GOLGB1 INVS PCNT

2.65e-0814891392328611215
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

USP17L21 USP17L12 USP17L20 USP17L11 RIBC1 USP17L19 USP17L18 USP17L17

2.87e-08119139828625976
Pubmed

A human MAP kinase interactome.

SUPT20H ANK3 RPS6KA5 CLIP2 MYO9A SPTAN1 CEP290 CEP350 POM121 HPS4 MACF1 PRKDC GOLGB1

8.70e-084861391320936779
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

LIMA1 RPS6KA5 MYCBP2 SPTAN1 PARG NUMA1 NBN ECPAS CLIP1 WTAP RAD50 PCF11 TRAPPC10 SCAF11 PRKDC GOLGA4

9.25e-087741391615302935
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 RIBC1 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 UBE2QL1 USP17L22 USP17L15

9.32e-086741391537196079
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RPGRIP1L SUPT20H MYO9A NBN ZDBF2 TUBGCP2 MORC4 RAD50 SMG7 RABEP1 MACF1 GOLGB1 PCNT NIN

1.13e-075881391438580884
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

LIMA1 EPPK1 NUMA1 ARHGAP11A CLIP1 CEP350 NOP14 PRKDC PCNT

1.87e-07210139916565220
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

LIMA1 DOCK8 SPTAN1 FRYL TUBGCP2 ECPAS CLIP1 RABEP1 TRAPPC10 PRKDC UTRN NIN

2.62e-074461391224255178
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

RPGRIP1L TUT7 CEP290 RIBC1 NBN TUBGCP2 ECPAS CLIP1 RAD50 CEP350 TBC1D31 SMG7 TLN1 ARHGAP12 PCNT NIN

3.41e-078531391628718761
Pubmed

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

CLIP2 CLIP1 SYNE2 MACF1 NIN

3.73e-0737139527565344
Pubmed

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

NBN RAD50 PRKDC

6.21e-075139324220101
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MYCBP2 CEP350 MACF1 PRKDC UTRN GOLGB1

6.35e-0776139627542412
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

RPGRIP1L ANK3 TUBGCP2 CEP350 TBC1D31 SMG7 RABEP1 SYNE2 NIN

8.34e-07251139929778605
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

CYLC2 SPTAN1 RAD50 TLN1 SYNE2 MACF1 MYOM2 UTRN

1.37e-06197139820811636
Pubmed

Inhibition of hsp90 compromises the DNA damage response to radiation.

NBN RAD50 PRKDC

2.16e-067139316982765
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

TRIM4 MYCBP2 ERO1A TUT7 CEP290 FYCO1 TUBGCP2 ECPAS RAD50 CEP350 CEP112 GOLGB1 PCNT NIN

2.17e-067541391433060197
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

LIMA1 ANK3 TRIM4 MYCBP2 SPTAN1 NUMA1 NBN RAD50 SMG7 RABEP1 TLN1 PRKDC

2.30e-065491391238280479
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

LIMA1 EPPK1 RPGRIP1L SPTAN1 CEP290 FYCO1 RABEP1 PRKDC FAR1 GOLGA4 GOLGB1 INVS

3.04e-065641391221565611
Pubmed

Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

NBN RAD50 PRKDC

3.45e-068139315456891
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

LIMA1 EPPK1 MYCBP2 CEP290 NUMA1 RAD50 CEP350 POM121 TLN1 SYNE2 MACF1 PRKDC FAR1 UTRN GOLGB1 PCNT

3.64e-0610241391624711643
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

CLIP2 MYCBP2 SMG7 TLN1 SYNE2 MACF1 PCNT NIN

3.69e-06225139812168954
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

EPPK1 DOCK8 SPTAN1 NBN TUBGCP2 RAD50 PCF11 TLN1 MACF1 PRKDC GOLGB1 PCNT

4.18e-065821391220467437
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

MYCBP2 ATAD5 SPTAN1 TAF1B NBN CPED1 NECAP1 CEP350 RAB34 SMG7 TLN1 FER MACF1

7.30e-067241391336232890
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

ANK3 SPTAN1 SPTB

7.34e-0610139322159418
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L1 USP17L3 USP17L15

7.34e-0610139324207026
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MYCBP2 ZDBF2 MORC4 ECPAS RAD50 RABEP1 FAR1 UTRN GOLGB1 PCNT

7.59e-064181391034709266
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

LIMA1 ANK3 CLIP2 MYCBP2 SPTAN1 NUMA1 FYCO1 CLIP1 RAD50 RABEP1 SYNE2 MACF1 GOLGA4 GOLGB1 PCNT

7.76e-069631391528671696
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ANK3 MYCBP2 VEZT ATAD5 ERO1A SPTAN1 GRAMD1A NBN PCF11 NOP14 TBC1D31 TLN1 SYNE2 MACF1 FAR1 GOLGA4 GOLGB1 PCNT NIN

7.79e-0614871391933957083
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

RPGRIP1L MYCBP2 VEZT ERO1A TUT7 CEP290 NBN ZDBF2 TUBGCP2 CEP350 NUDT12 TBC1D31 GOLGA4

8.33e-067331391334672954
Pubmed

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

NBN RAD50 PRKDC

1.01e-0511139315758953
Pubmed

MRE11 complex links RECQ5 helicase to sites of DNA damage.

NBN RAD50 PRKDC

1.01e-0511139319270065
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

CEP112 MACF1 UTRN GOLGB1

1.03e-0534139425925205
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

LIMA1 MYCBP2 SPTB NUMA1 WTAP TLN1 PRKDC

1.21e-05190139715161933
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L1 USP17L3 USP17L15

1.34e-0512139324695638
Pubmed

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

NBN RAD50 PRKDC

1.34e-0512139330017584
Pubmed

Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.

RPGRIP1L CEP290

1.59e-052139233625872
Pubmed

Role of gamma delta T cells in the inflammatory response of experimental colitis mice.

PRKDC IL7R

1.59e-052139214607957
Pubmed

Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.

MACF1 GOLGA4

1.59e-052139215265687
Pubmed

History-dependent catastrophes regulate axonal microtubule behavior.

CLIP2 CLIP1

1.59e-052139220471267
Pubmed

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.

NBN RAD50

1.59e-052139216474176
Pubmed

Variations in both α-spectrin (SPTA1) and β-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.

SPTAN1 SPTB

1.59e-052139224193021
Pubmed

NuMA1 promotes axon initial segment assembly through inhibition of endocytosis.

ANK3 NUMA1

1.59e-052139231727776
Pubmed

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

NBN RAD50

1.59e-052139216622404
Pubmed

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.

SYNE2 PCNT

1.59e-052139230054381
Pubmed

Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma.

DOCK8 PNLIPRP3

1.59e-052139219640199
Pubmed

Interactions of the alpha-spectrin N-terminal region with beta-spectrin. Implications for the spectrin tetramerization reaction.

SPTAN1 SPTB

1.59e-05213929890967
Pubmed

Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer.

NBN RAD50

1.59e-052139219904603
Pubmed

RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.

NBN RAD50

1.59e-052139221811815
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

ANK3 MYCBP2 ABCA13 SLFN5 HNMT PCF11 RABEP1 MACF1 PRKDC

1.59e-05361139926167880
Pubmed

Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.

CEP290 PCNT NIN

1.74e-0513139317920017
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

MYCBP2 ERO1A FYCO1 CLIP1 RABEP1 GOLGB1 PCNT NIN

2.05e-05285139832838362
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L1 USP17L3 USP17L15

2.20e-0514139311793228
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

ARMT1 EPPK1 ANK3 TRIM4 MYCBP2 SPTAN1 NUMA1 FYCO1 ECPAS TLN1 MACF1 PRKDC UTRN

2.28e-058071391330575818
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

LIMA1 ATAD5 PARG NUMA1 NBN RAD50 SMG7 RABEP1 TLN1 MACF1 PRKDC UTRN GOLGB1 PCNT

2.42e-059341391433916271
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

MYCBP2 FYCO1 TUBGCP2 CEP350 CEP112 GOLGB1 PCNT NIN

2.82e-05298139832353859
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ARMT1 MYCBP2 SPTB CLIP1 RABEP1 TLN1 SYNE2 MACF1 MYOM2 UTRN

3.34e-054971391023414517
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LIMA1 MYCBP2 MYO9A SPTAN1 FRYL CEP350 CEP112 RABEP1 SYNE2 MACF1 UTRN GOLGA4 GOLGB1

4.44e-058611391336931259
Pubmed

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

CEP290 FRYL CEP350 UTRN GOLGB1 PCNT

4.52e-05159139630581152
Pubmed

Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance.

NBN RAD50

4.75e-053139233090711
Pubmed

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

NBN RAD50

4.75e-053139212124328
Pubmed

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.

NBN RAD50

4.75e-053139211062235
Pubmed

Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.

NBN RAD50

4.75e-053139214684699
Pubmed

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

NBN RAD50

4.75e-053139228867292
Pubmed

Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma.

NBN RAD50

4.75e-053139217169801
InteractionCEP152 interactions

RPGRIP1L ANK3 MYO9A TUBGCP2 ECPAS TIPARP CEP350 SMG7 PCNT NIN

3.12e-0717913310int:CEP152
InteractionCTAGE1 interactions

CTAGE6 CTAGE8 CTAGE15 CTAGE4

3.69e-07101334int:CTAGE1
InteractionKCNA3 interactions

ADCY10 EPPK1 ANK3 MYO9A ABCA13 NUMA1 FYCO1 ECPAS CLIP1 RAD50 CEP112 TLN1 ARHGAP12 CAPRIN2 MACF1 PRKDC FAR1 GOLGA4 GOLGB1

4.52e-0687113319int:KCNA3
InteractionFLT3 interactions

USP17L21 EPPK1 USP17L12 USP17L20 USP17L11 RIBC1 USP17L19 ECPAS USP17L18 USP17L17 PRKDC

8.67e-0631813311int:FLT3
InteractionTMOD1 interactions

LIMA1 SPTAN1 ECPAS MACF1 GOLGA4 GOLGB1 PCNT NIN

1.17e-051611338int:TMOD1
InteractionATOH1 interactions

MYCBP2 CEP350 MACF1 PRKDC UTRN GOLGB1

1.49e-05801336int:ATOH1
InteractionARHGAP21 interactions

LIMA1 ANK3 MYCBP2 NECAP1 SYNE2 RASGEF1B FER PCNT NIN

1.76e-052231339int:ARHGAP21
InteractionPHF21A interactions

MYCBP2 ZDBF2 MORC4 ECPAS TIPARP RAD50 RABEP1 FAR1 UTRN GOLGB1 PCNT

1.76e-0534313311int:PHF21A
InteractionPCM1 interactions

RPGRIP1L MYCBP2 MYO9A CEP290 ECPAS TIPARP CEP350 TBC1D31 SMG7 CEP112 PCNT NIN

3.13e-0543413312int:PCM1
InteractionPCNT interactions

RPGRIP1L SPTAN1 CEP290 TUBGCP2 CEP350 MACF1 UTRN PCNT NIN

3.24e-052411339int:PCNT
InteractionSIRT7 interactions

EPPK1 MYCBP2 SPTAN1 TUT7 NUMA1 FRYL ECPAS RAD50 NOP14 TLN1 SYNE2 MACF1 SCAF11 PRKDC UTRN PCNT

3.25e-0574413316int:SIRT7
InteractionMAPRE1 interactions

LIMA1 CLIP2 VEZT SPTAN1 CEP290 NUMA1 CLIP1 TIPARP CEP350 TBC1D31 MACF1 PCNT NIN

3.65e-0551413313int:MAPRE1
InteractionVPS33B interactions

ANK3 TIPARP CEP350 TBC1D31 SMG7 RABEP1 SYNE2 NIN

5.36e-051991338int:VPS33B
InteractionCEP135 interactions

RPGRIP1L CEP290 CEP350 TBC1D31 SMG7 CEP112 GOLGB1 PCNT NIN

8.25e-052721339int:CEP135
InteractionOFD1 interactions

RPGRIP1L CEP290 NBN RAD50 CEP350 TBC1D31 SMG7 RABEP1 PCNT NIN

1.04e-0434713310int:OFD1
InteractionWWTR1 interactions

LIMA1 ANK3 TRIM4 MYCBP2 SPTAN1 NUMA1 NBN RAD50 SMG7 RABEP1 TLN1

1.14e-0442213311int:WWTR1
InteractionRPGRIP1L interactions

EPPK1 RPGRIP1L RAD50 CEP350 RABEP1 GOLGA4 PCNT NIN

1.26e-042251338int:RPGRIP1L
InteractionBORCS6 interactions

CLIP2 RIBC1 FYCO1 WTAP GOLGB1 PCNT NIN

1.37e-041701337int:BORCS6
InteractionPFN1 interactions

MYO9A DOCK8 SPTAN1 NBN CEP350 SMG7 RABEP1 SYNE2 MACF1 GOLGA4 GOLGB1 PCNT

1.43e-0450913312int:PFN1
InteractionKDM1A interactions

RPGRIP1L TRIM4 MYCBP2 FYCO1 ZDBF2 MORC4 ECPAS TIPARP RAD50 CEP350 SMG7 RABEP1 FAR1 UTRN GOLGB1 PCNT NIN

1.55e-0494113317int:KDM1A
Cytoband4p16.1

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15

1.57e-1779139124p16.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 EVC USP17L10 USP17L19 USP17L18 NOP14 USP17L17 USP17L22 USP17L15

8.69e-1522213914chr4p16
Cytoband7q35

CTAGE6 CTAGE8 CTAGE15 CTAGE4

2.43e-055513947q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

CTAGE6 CTAGE8 CTAGE15 CTAGE4

5.01e-05661394chr7q35
Cytoband10p11.2

ZNF248 ZNF33A

2.52e-048139210p11.2
Cytoband8p23.3

ZNF596 MYOM2

8.09e-041413928p23.3
GeneFamilyCTAGE family

CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4

3.12e-0915755907
GeneFamilyBRCA1 C complex|MRN complex

NBN RAD50

5.08e-0537521344
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

NBN RAD50

1.68e-0457521336
GeneFamilyEF-hand domain containing|Spectrins

SPTAN1 SPTB

3.52e-0477521113
GeneFamilyEF-hand domain containing|Plakins

EPPK1 MACF1

4.68e-048752939
GeneFamilyATP binding cassette subfamily A

ABCA4 ABCA13

1.50e-0314752805
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

TIPARP PARP6

2.22e-0317752684
CoexpressionMADAN_DPPA4_TARGETS

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

8.42e-168613813MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 ERO1A USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

9.93e-1611213814MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L21 USP17L12 ANK3 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 CAPRIN2 USP17L3 USP17L22 USP17L15

7.13e-1516013815MM1155
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

ARMT1 LIMA1 MYCBP2 MYO9A TAF1B TUT7 CEP290 NBN ARHGAP11A CLIP1 RAD50 TDRD7 CEP350 NUDT12 CEP112 RABEP1 SYNE2 CAPRIN2 FER SCAF11 GOLGA4 GOLGB1 NIN

6.16e-1365613823M18979
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L21 SUPT20H USP17L12 USP17L1 RPS6KA5 USP17L20 USP17L11 NUMA1 USP17L5 USP17L10 USP17L19 ECPAS ARHGAP11A CLIP1 TIPARP USP17L18 SMG7 USP17L17 ARHGAP12 USP17L3 USP17L22 USP17L15

4.59e-08107213822MM1031
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 MORC4 USP17L18 POM121 USP17L17 USP17L3 USP17L22 UTRN USP17L15

3.26e-0764713816MM981
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

USP17L21 ATP6V1C1 USP17L12 USP17L1 USP17L20 USP17L11 TUT7 PARG USP17L5 USP17L10 USP17L19 MORC4 TIPARP USP17L18 POM121 USP17L17 CEP112 CAPRIN2 USP17L3 USP17L22 UTRN USP17L15

4.61e-07122613822MM979
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SUPT20H MYCBP2 PARG NBN FRYL ARHGAP11A CLIP1 TIPARP TDRD7 CEP350 PCF11 TBC1D31 ARHGAP12 SYNE2 MACF1 GOLGA4 IL7R PCNT

6.12e-0785613818M4500
CoexpressionBRUINS_UVC_RESPONSE_LATE

USP17L21 ATP6V1C1 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 NBN USP17L10 USP17L19 CLIP1 WTAP USP17L18 USP17L17 RABEP1 TLN1 FER USP17L3 USP17L22 USP17L15

4.83e-06119813820MM1062
CoexpressionLAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2

TSHZ2 MYO9A CEP112 FER MACF1 UTRN

6.35e-06861386M39248
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

MYCBP2 PARG NBN FRYL CLIP1 TIPARP TDRD7 CEP350 ARHGAP12 GOLGA4 IL7R

3.78e-0546613811M13522
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

RPGRIP1L DOCK8 FRYL CEP350 TLN1 MACF1 UTRN

4.87e-051801387M8239
CoexpressionGSE22935_WT_VS_MYD88_KO_MACROPHAGE_48H_MBOVIS_BCG_STIM_UP

VEZT SPTB FRYL ZDBF2 MYOM2 UTRN PCNT

9.16e-051991387M7766
CoexpressionHALLMARK_MITOTIC_SPINDLE

CLIP2 SPTAN1 NUMA1 TUBGCP2 CLIP1 PCNT NIN

9.16e-051991387M5893
CoexpressionGSE8685_IL2_ACT_IL2_STARVED_VS_IL15_ACT_IL2_STARVED_CD4_TCELL_UP

CLIP2 VEZT GRAMD1A ACOT4 NECAP1 SYNE2 USP40

9.45e-052001387M331
CoexpressionGSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN

ARMT1 RPS6KA5 DOCK8 ABCA13 TAF1B PARG UTRN

9.45e-052001387M7505
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

SAMD9 RPS6KA5 MYCBP2 DOCK8 SPTAN1 GRAMD1A NUMA1 FRYL SLFN5 CLIP1 CEP350 PCF11 GVINP1 TLN1 TRAPPC10 MACF1 SCAF11 UTRN IL7R NIN

1.09e-04149213820M40023
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000

SWT1 MYO9A TDRD7 BRDT SNX25 CAPRIN2 PRKDC

6.26e-07851237gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k1_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

ATAD5 SPTAN1 PARG CEP290 ZDBF2 ECPAS PCF11 NOP14 POM121 SMG7 RABEP1 SCAF11 PRKDC PCNT

2.56e-0653212314Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_500

MYO9A TDRD7 BRDT CAPRIN2 PRKDC

2.59e-06381235gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k3_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#4_top-relative-expression-ranked_1000

MYO9A CEP350 CEP112 CAPRIN2 USP40

6.10e-06451235gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k4_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

ATAD5 CEP290 ZDBF2 CLIP1 RABEP1 SYNE2 PRKDC GOLGA4

1.64e-051921238Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

RPGRIP1L SWT1 MYO9A ATAD5 TUT7 CEP290 NUMA1 ZDBF2 CLIP1 ZNF248 RAD50 RABEP1 SYNE2 PRKDC CFAP69 GOLGA4

2.48e-0583112316Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

SWT1 MYO9A TDRD7 BRDT CAPRIN2 PRKDC

4.38e-051101236gudmap_dev gonad_e13.5_M_GermCell_Oct_k4_1000
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SAMD9 MYCBP2 DOCK8 FRYL SLFN5 CEP350 SYNE2 RASGEF1B MACF1 SCAF11 UTRN GOLGA4 GOLGB1

3.62e-142001321312f1685ce8f218433068e090c9d839cd5a1910bf
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 DOCK8 PARG SLFN5 CLIP1 CEP350 TLN1 MACF1 SCAF11 UTRN GOLGA4 IL7R

3.47e-13184132121154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 TSHZ2 SPTAN1 GRAMD1A LRRK1 NMNAT3 SYNE2 MACF1 UTRN GOLGB1 IL7R NIN

5.08e-131901321291ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

MYCBP2 CEP290 SLFN5 RAD50 CEP350 RABEP1 SYNE2 SCAF11 UTRN GOLGA4 GOLGB1

1.97e-111981321176d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 CLIP1 TIPARP PCF11 NOP14 SYNE2 SCAF11 FAR1 GOLGA4 GOLGB1

2.43e-1018713210663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

SAMD9 CEP290 SLFN5 CLIP1 RAD50 CEP350 SYNE2 CABCOCO1 GOLGA4 GOLGB1

4.46e-101991321061b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

LIMA1 CEP290 SLFN5 CLIP1 RAD50 CEP350 SYNE2 UTRN GOLGA4 GOLGB1

4.46e-1019913210c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUPT20H MYO9A PARG CPED1 CEP350 CEP112 FER MACF1 SCAF11

2.93e-091761329749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK3 TSHZ2 FRYL ZDBF2 SYNE2 MACF1 CTAGE4 UTRN GOLGA4

7.85e-09197132957ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

CEP290 SLFN5 CLIP1 RAD50 CEP350 SYNE2 SCAF11 GOLGA4 GOLGB1

8.58e-091991329fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 DOCK8 SLFN5 CLIP1 CEP350 MACF1 SCAF11 NIN

7.38e-081821328f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

ATP8B4 MYCBP2 DOCK8 FRYL MACF1 PRKDC FAR1 INVS

8.37e-081851328a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 DOCK8 SLFN5 CLIP1 CEP350 MACF1 SCAF11 NIN

8.37e-0818513287adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

ATP8B4 MYCBP2 DOCK8 FRYL MACF1 PRKDC FAR1 INVS

8.73e-0818613288571956890fc9894d766ba294a28e376b4aba428
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 ANK3 TSHZ2 SLFN5 TDRD7 ART3 SYNE2 IL7R

9.47e-0818813286f8946d4710f6e32c937213f99b790b098b8819c
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 SPTAN1 TLN1 MACF1 UTRN GOLGA4 GOLGB1 NIN

1.03e-071901328d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK3 RPS6KA5 TSHZ2 FRYL SYNE2 MACF1 CTAGE4 UTRN

1.16e-0719313289337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDBF2 TIPARP SYNE2 MACF1 UTRN GOLGA4 GOLGB1 IL7R

1.47e-071991328cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellCOVID-19|World / Disease, condition lineage and cell class

MYCBP2 TLN1 SYNE2 TRAPPC10 MACF1 UTRN GOLGA4 GOLGB1

1.52e-0720013287dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TUT7 SLFN5 ECPAS SYNE2 MACF1 MYOM2

1.01e-061771327d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TUT7 SLFN5 ECPAS SYNE2 MACF1 MYOM2

1.01e-061771327f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 MYO9A ABCA13 EVC NMNAT3 DNAH17 UTRN

1.01e-061771327da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

SAMD9 TUT7 SLFN5 ECPAS SYNE2 MACF1 MYOM2

1.01e-0617713276978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 TUT7 SLFN5 ECPAS SYNE2 MACF1 MYOM2

1.01e-061771327936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9 TUT7 SLFN5 ECPAS SYNE2 MACF1 MYOM2

1.01e-061771327d5aeda113afaa2425874394610344570c9078478
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMA1 DOCK8 ABCA13 ATAD5 ERO1A SYNE2 NIN

1.46e-06187132714c239af77116d28d511dea754b6150d20488080
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 MYO9A ZDBF2 CPED1 TDRD7 ZNF33B IL7R

1.51e-0618813276468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 MYO9A ZDBF2 CPED1 TDRD7 ZNF33B IL7R

1.51e-0618813277a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 MYO9A ZDBF2 CPED1 TDRD7 ZNF33B IL7R

1.51e-0618813279cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_CD8_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOCK8 SLFN5 SYNE2 RASGEF1B GOLGB1 IL7R NIN

1.56e-0618913272c8a2fb76ea002bac554bc1c761ce960b5e116e1
ToppCell(04)_Pre-ciliated|World / shred by cell type and Timepoint

ENKUR PTCHD3 ARHGAP11A ZFAND4 TBC1D31 CABCOCO1 PCNT

1.68e-06191132737cf121e6e80760c8519075b7845b9029958a988
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

ATP8B4 MYCBP2 FRYL MACF1 PRKDC FAR1 INVS

1.68e-0619113279454f642c3621370fa23640b631301346b300950
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 MACF1 IL7R

1.92e-0619513274bdedd924564a260841a9153604026b57487c83d
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 CPED1 CLIP1 TIPARP NOP14 CEP112 SCAF11

1.92e-0619513275c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLFN5 TBC1D31 SYNE2 TRAPPC10 MACF1 MYOM2 UTRN

2.13e-06198132758d805e827299292750b09c6283fdbe406b75f79
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK3 FRYL SYNE2 MACF1 UTRN GOLGA4 GOLGB1

2.20e-061991327f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

LIMA1 CEP290 SLFN5 RAD50 SYNE2 GOLGA4 GOLGB1

2.20e-06199132718a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

CEP290 SLFN5 CLIP1 RAD50 SYNE2 GOLGA4 GOLGB1

2.20e-06199132753ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellmild-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 MACF1 IL7R

2.20e-06199132706c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

LIMA1 SAMD9 SPTAN1 SLFN5 SMG7 SYNE2 MACF1

2.20e-061991327f307d4887b28cf60a591439e278fd668409cb104
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

LIMA1 SAMD9 SLFN5 RAD50 SYNE2 GOLGA4 GOLGB1

2.20e-061991327a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTAN1 SYNE2 MACF1 UTRN IL7R PCNT NIN

2.28e-062001327dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellVE|World / Condition, Cell_class and T cell subcluster

SAMD9 MYCBP2 SLFN5 SYNE2 MACF1 UTRN IL7R

2.28e-0620013278ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

SAMD9 ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.28e-062001327d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

SAMD9 SLFN5 RAD50 SYNE2 MACF1 MYOM2 UTRN

2.28e-0620013272281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ERO1A SPTAN1 SLFN5 SYNE2 CTAGE8 PNLIPRP3

2.52e-061301326d47d4ff1263815896470d854d25306eb36919e70
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ERO1A SPTAN1 SLFN5 SYNE2 CTAGE8 PNLIPRP3

2.52e-061301326ad57b210c96caedadc1027b4d7a56b1bc389b137
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-Tfh|Lung / Manually curated celltypes from each tissue

EPPK1 ANK3 TSHZ2 CEP112 SYNE2 IL7R

4.20e-061421326319812c84fad93276bf093f2ad78db02ae745bf4
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|normal_Lung / Location, Cell class and cell subclass

ZDBF2 MORC4 CEP350 SMG7 SLC9B2 INVS

1.03e-051661326ff32422390852546e0cb216192452e9c47bd9509
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-Th17|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 DOCK8 ATAD5 TBC1D31 BRDT IL7R

1.10e-05168132697bf074b91c9ae0064edc31fa4a2658ffdcfefa3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A ABCA13 EVC NMNAT3 DNAH17

1.18e-0517013265d5f208682be21ed58320f5fc083a7898f8712da
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 SLFN5 GVINP1 SYNE2 UTRN IL7R

1.22e-051711326e1fe07652c10c37191d1471ddaea500f74269e0c
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

ZDBF2 MORC4 CEP350 SMG7 SLC9B2 INVS

1.26e-0517213260657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A ABCA13 EVC NMNAT3 DNAH17 UTRN

1.43e-051761326327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUT7 SLFN5 GVINP1 SYNE2 SCAF11 UTRN

1.53e-05178132601dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VSNL1 CEP290 NMNAT3 TIPARP ART3 ATP1B2

1.68e-051811326274c0b768925cd5804483303f8c5ebd17a534c41
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

ANK3 TSHZ2 SPTAN1 SYNE2 MACF1 IL7R

1.68e-051811326f2315414e714ac86211546a935660c4be6e85f1b
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 ATAD5 CLIP1 MACF1 UTRN IL7R

1.73e-051821326e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 ATAD5 CLIP1 MACF1 UTRN IL7R

1.73e-0518213261710eab3037a87609d21838be2d2d29c3bc36651
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SAMD9 SLFN5 TIPARP CEP350 SYNE2 UTRN

1.79e-0518313268f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SUPT20H ANK3 TSHZ2 GRAMD1A SYNE2 IL7R

1.84e-051841326bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 TSHZ2 MYO9A ABCA13 EVC SYNE2

2.02e-0518713269225caf66e06ebe57e90d677122acb6498607f36
ToppCell(04)_Pre-ciliated-(3)_72hpi|(04)_Pre-ciliated / shred by cell type and Timepoint

ENKUR PTCHD3 RIBC1 ZFAND4 CABCOCO1 CFAP69

2.08e-051881326f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.14e-0518913269ab77c6fcb573854da5922412f53d2168bda6b58
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.14e-0518913265a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 MYO9A ABCA13 EVC SYNE2 UTRN

2.21e-051901326b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 MYO9A ABCA13 EVC SYNE2 UTRN

2.21e-051901326a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMA1 PARG CEP350 SYNE2 SCAF11 GOLGB1

2.27e-05191132660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMA1 PARG CEP350 SYNE2 SCAF11 GOLGA4

2.27e-05191132609db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMA1 PARG CEP350 SYNE2 SCAF11 GOLGB1

2.27e-051911326973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.34e-0519213267ab626a516b07d899175ff12f1c8257688324e4b
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WTAP CEP350 MACF1 SCAF11 IL7R

2.41e-05193132606b65110db974f4ef90d3511ff34428976a52c9c
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 ANK3 TSHZ2 SLFN5 SYNE2 IL7R

2.41e-0519313262901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WTAP CEP350 MACF1 SCAF11 IL7R

2.41e-0519313269c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

FRYL CEP350 TRAPPC10 SCAF11 PRKDC UTRN

2.41e-051931326abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WTAP CEP350 MACF1 SCAF11 IL7R

2.41e-051931326a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Severe / Disease group, lineage and cell class

SAMD9 ANK3 TSHZ2 SLFN5 SYNE2 IL7R

2.41e-051931326beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 ANK3 TSHZ2 SLFN5 SYNE2 IL7R

2.41e-051931326f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9 ANK3 TSHZ2 SLFN5 SYNE2 IL7R

2.41e-051931326f8af695457d2a0a911a5ac491742465864ebda37
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 ANK3 TSHZ2 SLFN5 SYNE2 IL7R

2.41e-051931326089aece40130034a89a5213be778f10b0787eeba
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WTAP CEP350 MACF1 SCAF11 IL7R

2.41e-051931326b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A ABCA13 ST6GAL2 DNAH17 SYNE2 RASGEF1B

2.48e-0519413268ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.55e-05195132622191d361af136942508f1553ff41a626ed982ad
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 FRYL MACF1 SCAF11 GOLGA4 GOLGB1

2.55e-0519513267796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANK3 SYNE2 MACF1 SCAF11 UTRN IL7R

2.63e-051961326ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

ANK3 TSHZ2 SPTAN1 SLFN5 SYNE2 IL7R

2.70e-051971326c842d169dfce9af3ed7c01dc7e940c0bdd21388c
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANK3 MYO9A CEP290 SYNE2 UTRN GOLGB1

2.70e-0519713263d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

TUT7 CEP290 RAD50 CEP350 CAPRIN2 GOLGB1

2.70e-0519713260fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

RIBC1 SLFN5 ACOT4 SYNE2 MACF1 UTRN

2.78e-05198132676d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SAMD9 SLFN5 SYNE2 MACF1 SCAF11 IL7R

2.78e-0519813264c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.78e-0519813260e918e9db9b884f5328d438e90efe065e27266ee
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLFN5 SYNE2 MACF1 MYOM2 UTRN GOLGA4

2.78e-05198132634c564ece9a2b94dcf646e3c95b5be9c5ecfaafe
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.78e-051981326ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.78e-051981326fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.78e-0519813261ef3a6bd681c223eed58300348adfef89df5563c
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

SAMD9 SLFN5 ART3 SYNE2 UTRN IL7R

2.78e-0519813264b078714c49e7befb7b113d72485e712236d35fa
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

EPPK1 SAMD9 SLFN5 SYNE2 MACF1 IL7R

2.78e-051981326ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.86e-051991326df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

LIMA1 RAD50 RABEP1 SYNE2 GOLGA4 GOLGB1

2.86e-05199132619674e1eaeb51e4196d847cb62aa437c852951d3
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SAMD9 SLFN5 SYNE2 MACF1 MYOM2 UTRN

2.86e-051991326ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

SLFN5 CEP350 SYNE2 MACF1 UTRN GOLGA4 GOLGB1

3.74e-0849747GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

ATAD5 CEP350 NOP14 SYNE2 MACF1 GOLGA4 GOLGB1

4.33e-0850747GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

CEP350 UTRN GOLGA4 GOLGB1

3.47e-0449744GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED
ComputationalNeighborhood of BMPR2

RPGRIP1L TBC1D31 ART3 INVS

4.70e-0453744MORF_BMPR2
DrugClorgyline

SAMD9 TUT7 CEP290 CLIP1 RAD50 CEP350 SCAF11 UTRN GOLGA4 GOLGB1

2.48e-0816812210ctd:D003010
Drugsemustine; Down 200; 100uM; PC3; HT_HG-U133A

RPS6KA5 ATAD5 SPTB NUMA1 LRRK1 HNMT RABEP1 MYH15

1.01e-0519412287492_DN
DrugRanitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ATP6V1C1 RPGRIP1L HNMT CLIP1 RAD50 SMG7 RABEP1 MACF1

1.09e-0519612285425_DN
Druggenistein; Up 200; 10uM; MCF7; HT_HG-U133A

SAMD9 SPTAN1 NUMA1 CPED1 HNMT CAPRIN2 FER UTRN

1.13e-0519712286994_UP
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

1.50e-224613314DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L21 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L15

8.86e-206913314DOID:1682 (implicated_via_orthology)
DiseaseCongenital cataract

FYCO1 TDRD7

2.99e-0461332C0009691
DiseaseX-16935 measurement

ATP8B4 ACOT4

4.17e-0471332EFO_0800763
Diseaseinfluenza A (H1N1)

CEP290 NUMA1 TUBGCP2 PNLIPRP3

6.57e-04871334EFO_1001488
DiseaseNephronophthisis

RPGRIP1L INVS

7.11e-0491332cv:C0687120
Disease6-bromotryptophan measurement

ERO1A SLC17A1

7.11e-0491332EFO_0800099
Diseaseciliopathy (implicated_via_orthology)

RPGRIP1L CEP290 INVS

7.83e-04401333DOID:0060340 (implicated_via_orthology)
DiseaseMeckel-Gruber syndrome

RPGRIP1L CEP290

8.86e-04101332cv:C0265215
Diseasebrain infarction (implicated_via_orthology)

PARG HNMT

1.08e-03111332DOID:3454 (implicated_via_orthology)
DiseaseRenal dysplasia and retinal aplasia (disorder)

CEP290 INVS

1.29e-03121332C0403553
DiseaseCiliopathies

RPGRIP1L CEP290 EVC INVS

1.57e-031101334C4277690
DiseaseHereditary Breast and Ovarian Cancer Syndrome

NBN RAD50

1.77e-03141332C0677776
Diseaseurate measurement, bone density

TSHZ2 TAF1B PARG FADS2B CLIP1 TIPARP USP40 PRKDC UTRN

2.02e-036191339EFO_0003923, EFO_0004531
DiseaseMeckel-Gruber syndrome

RPGRIP1L CEP290

2.04e-03151332C0265215
Diseaselevel of Sphingomyelin (d32:1) in blood serum

RABEP1 SYNE2

2.62e-03171332OBA_2045173
Disease4-ethylphenylsulfate measurement

ATP8B4 SLC17A1

2.94e-03181332EFO_0021148
DiseaseMeckel syndrome type 1

RPGRIP1L CEP290

2.94e-03181332C3714506
DiseasePhenyllactate (PLA) measurement

ST6GAL2 SLC17A1

3.28e-03191332EFO_0021662
Diseasecolorectal cancer, inflammatory bowel disease

ATP8B4 PTCHD3

3.28e-03191332EFO_0003767, MONDO_0005575
DiseaseSevere Combined Immunodeficiency

PRKDC IL7R

3.63e-03201332C0085110
DiseaseFamilial aplasia of the vermis

RPGRIP1L CEP290

3.63e-03201332cv:C0431399
DiseaseDown syndrome (is_marker_for)

HNMT PCNT

4.39e-03221332DOID:14250 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
KEEWHKFIQLLTEFQ

ATAD5

1486

Q96QE3
DFNWLIEQVKHSNHK

ARMT1

296

Q9H993
THSQKSEDWNIFDVK

CABCOCO1

46

Q8IVU9
TSHKQLFQQEAEVWK

CTAGE4

221

Q8IX94
TSHKQLFQQEAEVWK

CTAGE6

221

Q86UF2
TSHKQLFQQEAEVWK

CTAGE8

221

P0CG41
TSHKQLFQQEAEVWK

CTAGE9

221

A4FU28
TSHKQLFQQEAEVWK

CTAGE15

221

A4D2H0
QDWEKHFLDASTSKQ

CALR3

226

Q96L12
NETLQEWQKVHGTKF

CPED1

791

A4D0V7
LKHLETEDNIKVWFN

ABCA4

1606

P78363
EHQQSSEAQDKSKLW

BRDT

891

Q58F21
ADNFVSTHLDKQEWN

BOD1L2

76

Q8IYS8
LSEEELHEKFNQLWK

GVINP1

1881

Q7Z2Y8
QSTESLNNDWEKKLH

CEP112

346

Q8N8E3
TSANDFKWFELNQLK

ABCA13

471

Q86UQ4
DNWKSKLDSLASDHQ

CLIP2

611

Q9UDT6
SELSKKSWNQQHFAL

CYLC2

21

Q14093
SWKDSKHSLNNEKII

ATP8B4

216

Q8TF62
ATLHENDLWFSNIKE

DPY19L3

66

Q6ZPD9
ESEEKTNRTWNNLFK

ADCY10

756

Q96PN6
TEWAEILALQKQFHS

GRAMD1A

661

Q96CP6
HAQWQKEGNDKDFTL

HMGCS1

241

Q01581
EHTKQWLADALKEND

RAB34

141

Q9BZG1
LEDWLHSKSKEINQT

RAD50

576

Q92878
LKHTWQKANDQFLES

RABEP1

276

Q15276
SETEWNLLQKEVHNA

RABEP1

511

Q15276
QKWQSVFNDSQEHLE

TIPARP

276

Q7Z3E1
NKDVKDAFWKLIHTQ

OR5D14

296

Q8NGL3
DDQHFAKQDWTLLKQ

KIAA1107

1176

Q9UPP5
VQFIWKKHLFEDSQN

PNLIPRP3

416

Q17RR3
EDKKTFNIDVRQLHW

FAR1

416

Q8WVX9
HKDLWASKNENEEIL

LIMA1

461

Q9UHB6
SAAHEEQWKLKEQQL

RPGRIP1L

371

Q68CZ1
VFWKNHLKDVDFSEN

LRRK1

446

Q38SD2
LESLKHQQDALWTEK

GOLGA4

616

Q13439
LWQKSDALEFQQKLS

FYCO1

1151

Q9BQS8
ESWDQHVQKLNKFLE

ATP1B2

101

P14415
SDLHKIFNSLWNLDQ

HPS4

151

Q9NQG7
DLELKSKQSLIDWNN

ECPAS

281

Q5VYK3
SNLENVKFAWHKETS

HNMT

106

P50135
KSTKVFHENQLAIWN

KIAA1586

771

Q9HCI6
KWQNEGKHTEQLLES

PARG

156

Q86W56
WLDNILDSLDKKVHQ

FRYL

1136

O94915
WHILEKNLKSASNID

TUBGCP2

706

Q9BSJ2
QEKDENKWTHVNLSS

IL7R

171

P16871
EIKEHLFFQKINWDD

RPS6KA5

311

O75582
LDQDWKEIQTLLSHK

NOP14

221

P78316
HVNFEKFWELAKQVS

RASGEF1B

396

Q0VAM2
DFEEQLWKKDSLHQT

PCNT

996

O95613
HKEANSVLQWLESKE

MACF1

4471

Q9UPN3
AVNHDEKLDLNDSKW

ARHGAP12

706

Q8IWW6
HKNSQLVKDFQELWS

FADS2B

141

A8MWK0
WEENKSLQQVDEHSK

PCF11

601

O94913
KASLQWFNQALEDKS

POM121

541

Q96HA1
KNLDELLATHKNLSW

CCDC105

431

Q8IYK2
EQTHWRQANEKLDKT

DOCK8

1401

Q8NF50
AHFLKEVTSWQQKLS

DNAH17

1466

Q9UFH2
QADSSLNKFKQTAWD

CEP290

1591

O15078
DLKNSHEAVLKLQDW

FER

6

P16591
HEQKNTKEKDLSWSE

CEP350

2351

Q5VT06
ETWKEHQFDSKNEDL

ANK3

1086

Q12955
KSWENNVESQKHSLT

CAPRIN2

546

Q6IMN6
KKNWEEVHKEFQSLS

ENKUR

201

Q8TC29
EETQKAVLQWTKHDD

ERO1A

146

Q96HE7
RQKEELLTQQHKAFW

EVC

416

P57679
TKDKLEQAQNELSAW

WTAP

131

Q15007
HKQRELANKSWEDFL

CFAP69

826

A5D8W1
KLKESHWEENRNENS

SCAF11

1041

Q99590
HANKENSDVIALWKS

CLIP1

611

P30622
DVQSKQWLTHLLDQF

PTCHD3

336

Q3KNS1
HLENDKNNISWLKED

MDFIC2

16

A0A1B0GVS7
WLKEDTQLTNAKHAD

MDFIC2

26

A0A1B0GVS7
EEHSKATQEWLEKQA

NUMA1

346

Q14980
QWKHLSNDFLKTQQE

PARP6

141

Q2NL67
SNDFLKTQQEKRHSW

PARP6

146

Q2NL67
EVDTQDKNKQTALHW

INVS

141

Q9Y283
SDEHNDVQKKTFTKW

UTRN

26

P46939
KLNHNDWIKQYETLA

ATP6V1C1

191

P21283
KVSDHIQWFNKLSLN

ARHGAP11A

806

Q6P4F7
TDWQIQSLHKQKCDD

TBC1D31

896

Q96DN5
KWFLKQEINAAVEHA

TBC1D31

971

Q96DN5
NLKIKWENLSNHVTD

SYNE2

2576

Q8WXH0
LEEQWLSLNKKIDHE

SYNE2

4921

Q8WXH0
EIDDKLNKINDRWQH

SYNE2

5991

Q8WXH0
EQKSWEHQSASLKSQ

NIN

1746

Q8N4C6
LWSAKEISNNDKLQD

NBN

631

O60934
FWESVEHLKNANKNE

SNX25

316

Q9H3E2
KEDVNQWLESHKIDQ

SAMD9

16

Q5K651
FEWSLSNLAEKHNEK

TAF1B

376

Q53T94
ADWKQKHEESQALLD

MYH15

1466

Q9Y2K3
ATAEIQDWAKEKQHT

SLC17A1

451

Q14916
ALDKKVEQDLWNHAF

SMG7

51

Q92540
LIEKQETSNKHLWFQ

EPPK1

2161

P58107
KVQTFQGDDDHNWKI

MEP1A

376

Q16819
LEQERNHWQSEFKKV

MORC4

796

Q8TE76
VINDNVQIKHKWSSS

SLC9B2

161

Q86UD5
LQKWAQSQDGFEHKE

ST6GAL2

96

Q96JF0
VHENLNSWIELKKFS

MYCBP2

2086

O75592
EKRNNSDWLLAKESH

NUDT12

131

Q9BQG2
ITNADLWKHQKDVFL

TDRD7

836

Q8NHU6
HFINDSLKNQDRKLW

SWT1

451

Q5T5J6
HSKAQEDAWKQILAF

ACOT4

391

Q8N9L9
ESTLDHWKFLQEQNK

USP17L3

431

A6NCW0
DWNVKLHQVDKDSVL

UBE2QL1

26

A1L167
KIFSDWLSFNQHKEI

ZNF596

146

Q8TC21
LKERSQENQSKHLWE

ZNF33B

91

Q06732
LVKSTEFNEHELKQW

VSNL1

16

P62760
KQAHRQAEKTLDTEW

RIBC1

296

Q8N443
LKQKLHTDDELNWLD

TLN1

161

Q9Y490
AQFVEHWKELKQLAA

SPTAN1

1846

Q13813
KHSELEKQDNSWKET

SOGA1

886

O94964
TSDNHKWTQEDKLLL

SUPT20H

181

Q8NEM7
ESTLDHWKFLQEQNK

USP17L18

431

D6R9N7
ESTLDHWKFLQEQNK

USP17L5

431

A8MUK1
QEEKHLVFNKTAFWE

ZDBF2

341

Q9HCK1
ESTLDHWKFLQEQNK

USP17L21

431

D6R901
ESTLDHWKFLQEQNK

USP17L19

431

D6RCP7
WDELQATTKEKTQHL

SPTB

1361

P11277
ESTLDHWKFLQEQNK

USP17L1

431

Q7RTZ2
SNKSDFDWHQDALSK

TSHZ2

161

Q9NRE2
LIHWFTNNKKFESQD

PRKDC

991

P78527
KERSQENQSKHLWEV

ZNF33A

91

Q06730
KKDQHWKFQTLEESF

ZNF658

201

Q5TYW1
ESTLDHWKFLQEQNK

USP17L12

431

C9JPN9
ESTLDHWKFLQEQNK

USP17L24

431

Q0WX57
DDLTKWQNVLKAHSS

TRAPPC10

106

P48553
EAERQKWKQLLFSDH

VEZT

596

Q9HBM0
HLQDVEVKNATQWKD

TRIM4

176

Q9C037
FLKEDNSWENNTLSH

ZFAND4

316

Q86XD8
NDSHKDQSKRWLSDE

TUT7

91

Q5VYS8
ESTLDHWKFLQEQNK

USP17L22

431

D6RA61
ESTLDHWKFLQEQNK

USP17L15

431

C9J2P7
ESTLDHWKFLQEQNK

USP17L17

431

D6RBQ6
KDVDHLGNWQFQEEK

USP40

311

Q9NVE5
LKDISVKENNLEEHW

TERB1

391

Q8NA31
KENHFLIFVKSWNTE

SLFN5

91

Q08AF3
WELLFHNNKTVSVEN

ZNF248

101

Q8NDW4
ESTLDHWKFLQEQNK

USP17L20

431

D6RJB6
ESTLDHWKFLQEQNK

USP17L10

431

C9JJH3
SQWKDQNIEDHFEKP

ZNF669

131

Q96BR6
ESTLDHWKFLQEQNK

USP17L11

431

C9JVI0
RLEHDKQIWESKAQT

GOLGB1

2256

Q14789
LKEEKASHQQLDTVW

ART3

56

Q13508
NQKLEDHSEKNWKLE

ART3

286

Q13508
NWKLEDHGEKNQKLE

ART3

296

Q13508
ALNEKNQHDTFDIAW

MYO9A

786

B2RTY4
VIWFKNDQDIQLSEH

MYOM2

1376

P54296
VSLQDHFKWVKQESE

NECAP1

121

Q8NC96
NLWKDAHIQEIVEKF

NMNAT3

146

Q96T66