Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	STARD3 SLCO4A1 SERINC3 SLC36A3 MFSD8 ATP6V0A1 SLC4A7 TMC5 CLCN6 SLC9C2 ABCA13 ABCA9 SLC2A3 RYR1 RYR2 SIDT1	7.58e-10	1289	39	16	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLCO4A1 SERINC3 SLC36A3 MFSD8 ATP6V0A1 SLC4A7 TMC5 CLCN6 SLC9C2 ABCA13 ABCA9 SLC2A3 RYR1 RYR2 SIDT1	2.25e-09	1180	39	15	GO:0022857
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLCO4A1 SLC36A3 ATP6V0A1 SLC4A7 CLCN6 SLC9C2 ABCA13 ABCA9	3.21e-06	477	39	8	GO:0022804
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC36A3 MFSD8 ATP6V0A1 SLC4A7 TMC5 CLCN6 SLC9C2 RYR1 RYR2	1.70e-05	793	39	9	GO:0015075
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	2.22e-05	4	39	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	5.55e-05	6	39	2	GO:0048763
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL2 ELOVL7	7.76e-05	7	39	2	GO:0009922
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC36A3 MFSD8 ATP6V0A1 SLC4A7 CLCN6 SLC9C2 RYR1 RYR2	8.99e-05	758	39	8	GO:0015318
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLCO4A1 SERINC3 SLC36A3 SLC4A7 SLC2A3	2.52e-04	293	39	5	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO4A1 SLC36A3 SLC4A7 CLCN6 SLC9C2	2.64e-04	296	39	5	GO:0015291
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	5.58e-04	18	39	2	GO:0015278
GeneOntologyMolecularFunction	lipid transporter activity	STARD3 SLCO4A1 ABCA13 ABCA9	5.66e-04	196	39	4	GO:0005319
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP6V0A1 ABCA13 ABCA9	1.25e-03	109	39	3	GO:0042626
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC36A3 ATP6V0A1 SLC4A7 SLC9C2 RYR1 RYR2	1.26e-03	627	39	6	GO:0022890
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2	1.67e-03	31	39	2	GO:0099604
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC36A3 ATP6V0A1 SLC4A7 SLC9C2 RYR1 RYR2	1.69e-03	664	39	6	GO:0008324
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2	1.89e-03	33	39	2	GO:0005217
GeneOntologyMolecularFunction	monoatomic ion channel activity	MFSD8 TMC5 CLCN6 RYR1 RYR2	1.90e-03	459	39	5	GO:0005216
GeneOntologyMolecularFunction	antiporter activity	SLC4A7 CLCN6 SLC9C2	2.46e-03	138	39	3	GO:0015297
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC36A3 ATP6V0A1 SLC4A7 SLC9C2	2.75e-03	301	39	4	GO:0022853
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	MFSD8 SLC4A7 CLCN6	3.17e-03	151	39	3	GO:0008509
GeneOntologyMolecularFunction	channel activity	MFSD8 TMC5 CLCN6 RYR1 RYR2	3.39e-03	525	39	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	MFSD8 TMC5 CLCN6 RYR1 RYR2	3.42e-03	526	39	5	GO:0022803
GeneOntologyMolecularFunction	gated channel activity	TMC5 CLCN6 RYR1 RYR2	3.99e-03	334	39	4	GO:0022836
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA13 ABCA9	4.13e-03	49	39	2	GO:0140359
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	MFSD8 SLC4A7 CLCN6	4.50e-03	171	39	3	GO:0015103
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ATP6V0A1 ABCA13 ABCA9	5.03e-03	178	39	3	GO:0015399
GeneOntologyMolecularFunction	cholesterol binding	STARD3 SIDT1	5.73e-03	58	39	2	GO:0015485
GeneOntologyMolecularFunction	proton transmembrane transporter activity	SLC36A3 ATP6V0A1 SLC9C2	5.85e-03	188	39	3	GO:0015078
GeneOntologyMolecularFunction	sterol binding	STARD3 SIDT1	8.48e-03	71	39	2	GO:0032934
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SERINC3 SLC36A3	8.48e-03	71	39	2	GO:0015179
GeneOntologyMolecularFunction	double-stranded RNA binding	TLR8 SIDT1	1.02e-02	78	39	2	GO:0003725
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SERINC3 SLC36A3	1.14e-02	83	39	2	GO:0015101
GeneOntologyMolecularFunction	cargo receptor activity	TMED1 TMED3	1.20e-02	85	39	2	GO:0038024
GeneOntologyMolecularFunction	chloride channel activity	MFSD8 CLCN6	1.23e-02	86	39	2	GO:0005254
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC4A7 SLC9C2 RYR1 RYR2	1.25e-02	465	39	4	GO:0046873
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC36A3 MFSD8 ATP6V0A1 SLC4A7 TMC5 CLCN6 SLC9C2 RYR1 RYR2 ALG10	3.92e-05	1115	40	10	GO:0034220
GeneOntologyBiologicalProcess	monoatomic ion transport	SLCO4A1 SLC36A3 MFSD8 ATP6V0A1 SLC4A7 TMC5 CLCN6 SLC9C2 RYR1 RYR2 ALG10	4.21e-05	1374	40	11	GO:0006811
GeneOntologyBiologicalProcess	fatty acid elongation, polyunsaturated fatty acid	ELOVL2 ELOVL7	7.65e-05	7	40	2	GO:0034626
GeneOntologyBiologicalProcess	fatty acid elongation, monounsaturated fatty acid	ELOVL2 ELOVL7	7.65e-05	7	40	2	GO:0034625
GeneOntologyBiologicalProcess	fatty acid elongation, unsaturated fatty acid	ELOVL2 ELOVL7	7.65e-05	7	40	2	GO:0019368
GeneOntologyBiologicalProcess	fatty acid elongation, saturated fatty acid	ELOVL2 ELOVL7	1.02e-04	8	40	2	GO:0019367
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC36A3 MFSD8 ATP6V0A1 SLC4A7 CLCN6 SLC9C2 RYR1 RYR2 ALG10	1.14e-04	1017	40	9	GO:0098660
GeneOntologyBiologicalProcess	cellular response to caffeine	RYR1 RYR2	1.99e-04	11	40	2	GO:0071313
GeneOntologyBiologicalProcess	very long-chain fatty acid biosynthetic process	ELOVL2 ELOVL7	2.82e-04	13	40	2	GO:0042761
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	RYR1 RYR2	3.29e-04	14	40	2	GO:0071415
GeneOntologyBiologicalProcess	fatty acid elongation	ELOVL2 ELOVL7	3.79e-04	15	40	2	GO:0030497
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA biosynthetic process	ELOVL2 ELOVL7	6.14e-04	19	40	2	GO:0035338
GeneOntologyCellularComponent	vacuolar membrane	GPR137B STARD3 SLC36A3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1	3.00e-07	507	39	9	GO:0005774
GeneOntologyCellularComponent	lysosomal membrane	GPR137B STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1	1.81e-06	462	39	8	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	GPR137B STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1	1.81e-06	462	39	8	GO:0098852
GeneOntologyCellularComponent	endoplasmic reticulum membrane	STARD3 RHBDD2 TMED1 FMO1 TLR8 FAM8A1 ELOVL2 RYR1 RYR2 ELOVL7 ALG10 TMED3	2.44e-06	1293	39	12	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	STARD3 RHBDD2 TMED1 FMO1 TLR8 FAM8A1 ELOVL2 RYR1 RYR2 ELOVL7 ALG10 TMED3	2.56e-06	1299	39	12	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	STARD3 RHBDD2 TMED1 FMO1 TLR8 FAM8A1 ELOVL2 RYR1 RYR2 ELOVL7 ALG10 TMED3	3.20e-06	1327	39	12	GO:0042175
GeneOntologyCellularComponent	vacuole	GPR137B STARD3 SLC36A3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1 SIDT1	4.82e-06	913	39	10	GO:0005773
GeneOntologyCellularComponent	lysosome	GPR137B STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1 SIDT1	1.42e-05	811	39	9	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	GPR137B STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 FPR1 SIDT1	1.42e-05	811	39	9	GO:0000323
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	1.51e-04	10	39	2	GO:0014701
GeneOntologyCellularComponent	ficolin-1-rich granule membrane	ATP6V0A1 SLC2A3 FPR1	2.00e-04	61	39	3	GO:0101003
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 SLC2A3 FPR1 TMED3	5.45e-04	1307	39	9	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	STARD3 MFSD8 ATP6V0A1 CLCN6 ABCA13 TLR8 SLC2A3 FPR1 TMED3	6.02e-04	1325	39	9	GO:0012506
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR2	3.19e-03	45	39	2	GO:0033017
GeneOntologyCellularComponent	secretory granule membrane	ATP6V0A1 ABCA13 SLC2A3 FPR1	3.21e-03	329	39	4	GO:0030667
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR2	3.33e-03	46	39	2	GO:0005790
GeneOntologyCellularComponent	tertiary granule	ATP6V0A1 SLC2A3 FPR1	3.52e-03	164	39	3	GO:0070820
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	RYR1 RYR2	4.90e-03	56	39	2	GO:0031234
GeneOntologyCellularComponent	ficolin-1-rich granule	ATP6V0A1 SLC2A3 FPR1	4.93e-03	185	39	3	GO:0101002
GeneOntologyCellularComponent	endosome membrane	STARD3 MFSD8 ATP6V0A1 CLCN6 TLR8	4.99e-03	602	39	5	GO:0010008
GeneOntologyCellularComponent	azurophil granule membrane	ABCA13 FPR1	5.43e-03	59	39	2	GO:0035577
GeneOntologyCellularComponent	calcium channel complex	RYR1 RYR2	8.20e-03	73	39	2	GO:0034704
Domain	RyR	RYR1 RYR2	1.27e-05	3	39	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	1.27e-05	3	39	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	1.27e-05	3	39	2	PF06459
Domain	Ryanrecept_TM4-6	RYR1 RYR2	1.27e-05	3	39	2	IPR009460
Domain	Ryan_recept	RYR1 RYR2	1.27e-05	3	39	2	IPR013333
Domain	ELO_CS	ELOVL2 ELOVL7	6.34e-05	6	39	2	IPR030457
Domain	RIH_assoc	RYR1 RYR2	6.34e-05	6	39	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	6.34e-05	6	39	2	IPR013662
Domain	RYDR_ITPR	RYR1 RYR2	6.34e-05	6	39	2	PF01365
Domain	RIH_dom	RYR1 RYR2	6.34e-05	6	39	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	6.34e-05	6	39	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	6.34e-05	6	39	2	IPR015925
Domain	Ins145_P3_rec	RYR1 RYR2	6.34e-05	6	39	2	PF08709
Domain	-	RYR1 RYR2	6.34e-05	6	39	2	1.25.10.30
Domain	ELO	ELOVL2 ELOVL7	8.86e-05	7	39	2	PF01151
Domain	ELO	ELOVL2 ELOVL7	8.86e-05	7	39	2	PS01188
Domain	ELO_fam	ELOVL2 ELOVL7	8.86e-05	7	39	2	IPR002076
Domain	TMP21-related	TMED1 TMED3	1.18e-04	8	39	2	IPR015720
Domain	EMP24_GP25L	TMED1 TMED3	1.52e-04	9	39	2	SM01190
Domain	MIR	RYR1 RYR2	1.89e-04	10	39	2	PS50919
Domain	MIR	RYR1 RYR2	1.89e-04	10	39	2	PF02815
Domain	MIR	RYR1 RYR2	1.89e-04	10	39	2	SM00472
Domain	MIR_motif	RYR1 RYR2	1.89e-04	10	39	2	IPR016093
Domain	ABC_A	ABCA13 ABCA9	2.77e-04	12	39	2	IPR026082
Domain	EMP24_GP25L	TMED1 TMED3	4.39e-04	15	39	2	PF01105
Domain	GOLD_dom	TMED1 TMED3	7.10e-04	19	39	2	IPR009038
Domain	GOLD	TMED1 TMED3	7.10e-04	19	39	2	PS50866
Domain	MFS	SLCO4A1 MFSD8 SLC2A3	1.48e-03	108	39	3	PS50850
Domain	EF-hand_8	RYR1 RYR2	2.29e-03	34	39	2	PF13833
Domain	MFS_dom	SLCO4A1 MFSD8 SLC2A3	2.73e-03	134	39	3	IPR020846
Domain	ABC_TRANSPORTER_2	ABCA13 ABCA9	4.51e-03	48	39	2	PS50893
Domain	ABC_tran	ABCA13 ABCA9	4.51e-03	48	39	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA13 ABCA9	4.70e-03	49	39	2	PS00211
Domain	ABC_transporter-like	ABCA13 ABCA9	4.89e-03	50	39	2	IPR003439
Domain	VWA	ITGA11 COL12A1	6.09e-03	56	39	2	PF00092
Domain	ConA-like_dom	COL12A1 RYR1 RYR2	1.07e-02	219	39	3	IPR013320
Domain	VWFA	ITGA11 COL12A1	1.27e-02	82	39	2	PS50234
Domain	VWA	ITGA11 COL12A1	1.33e-02	84	39	2	SM00327
Domain	SPRY	RYR1 RYR2	1.42e-02	87	39	2	SM00449
Domain	SPRY	RYR1 RYR2	1.65e-02	94	39	2	PF00622
Domain	SPRY_dom	RYR1 RYR2	1.65e-02	94	39	2	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2	1.68e-02	95	39	2	IPR001870
Domain	B302_SPRY	RYR1 RYR2	1.68e-02	95	39	2	PS50188
Domain	VWF_A	ITGA11 COL12A1	1.81e-02	99	39	2	IPR002035
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLCO4A1 ATP6V0A1 SLC4A7 CLCN6 SLC9C2 ABCA9 SLC2A3 RYR1 RYR2	1.96e-05	736	31	9	M27287
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V0A1 CLCN6 SLC9C2 RYR1 RYR2	4.51e-05	183	31	5	M997
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN6 SLC9C2 RYR1 RYR2	8.13e-05	106	31	4	M27200
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLCO4A1 ATP6V0A1 SLC4A7 CLCN6 ABCA9 SLC2A3 RYR1 RYR2	8.34e-05	681	31	8	MM14985
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR2	2.54e-04	11	31	2	M47958
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL2 ELOVL7	3.05e-04	12	31	2	MM17077
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2	3.60e-04	13	31	2	M39589
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V0A1 CLCN6 RYR1 RYR2	5.68e-04	176	31	4	MM15718
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2	7.82e-04	19	31	2	M47760
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL2 ELOVL7	1.05e-03	22	31	2	MM15451
Pathway	KEGG_MEDICUS_REFERENCE_COPI_VESICLE_FORMATION	TMED1 TMED3	1.15e-03	23	31	2	M47772
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL2 ELOVL7	1.25e-03	24	31	2	M1016
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN6 RYR1 RYR2	1.31e-03	99	31	3	MM14910
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL2 ELOVL7	2.23e-03	32	31	2	MM15446
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	1.29e-06	2	40	2	17259277
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	1.29e-06	2	40	2	30542613
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	1.29e-06	2	40	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	1.29e-06	2	40	2	15033925
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	1.29e-06	2	40	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	1.29e-06	2	40	2	26009179
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	1.29e-06	2	40	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	1.29e-06	2	40	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	1.29e-06	2	40	2	11673462
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	1.29e-06	2	40	2	18618700
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	1.29e-06	2	40	2	32899693
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	3.87e-06	3	40	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	3.87e-06	3	40	2	7621815
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	3.87e-06	3	40	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	3.87e-06	3	40	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	3.87e-06	3	40	2	11159936
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	3.87e-06	3	40	2	23278119
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	3.87e-06	3	40	2	7876312
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	3.87e-06	3	40	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	3.87e-06	3	40	2	18403125
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	3.87e-06	3	40	2	21881589
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	3.87e-06	3	40	2	9986730
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	3.87e-06	3	40	2	24123915
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	3.87e-06	3	40	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	3.87e-06	3	40	2	23454728
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	3.87e-06	3	40	2	10788707
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	3.87e-06	3	40	2	18434746
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	3.87e-06	3	40	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	3.87e-06	3	40	2	7959768
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	3.87e-06	3	40	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	3.87e-06	3	40	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	3.87e-06	3	40	2	7635066
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	7.73e-06	4	40	2	9384575
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	7.73e-06	4	40	2	18206662
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	7.73e-06	4	40	2	19120137
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	7.73e-06	4	40	2	22504960
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	7.73e-06	4	40	2	11237759
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	7.73e-06	4	40	2	9607712
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	7.73e-06	4	40	2	23992453
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	7.73e-06	4	40	2	23482488
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	7.73e-06	4	40	2	23413940
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	7.73e-06	4	40	2	27226555
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	1.29e-05	5	40	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	1.29e-05	5	40	2	9124414
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	1.29e-05	5	40	2	19011160
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	1.29e-05	5	40	2	23918386
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	1.93e-05	6	40	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	1.93e-05	6	40	2	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	1.93e-05	6	40	2	16844763
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	1.93e-05	6	40	2	26025922
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	1.93e-05	6	40	2	14592808
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	1.93e-05	6	40	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	1.93e-05	6	40	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	1.93e-05	6	40	2	25966694
Pubmed	Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.	TMED1 TMED3	1.93e-05	6	40	2	12237308
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	2.70e-05	7	40	2	20962236
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	2.70e-05	7	40	2	11860456
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	3.60e-05	8	40	2	11784029
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	3.60e-05	8	40	2	19033399
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL2 ELOVL7	5.77e-05	10	40	2	20937905
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	5.77e-05	10	40	2	18434328
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL2 ELOVL7	7.05e-05	11	40	2	23689133
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	8.45e-05	12	40	2	19095005
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	1.16e-04	14	40	2	28724790
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	GPR137B RYR2	1.16e-04	14	40	2	11472062
Pubmed	Integral and associated lysosomal membrane proteins.	STARD3 MFSD8 CLCN6	4.16e-04	126	40	3	17897319
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	ELOVL2 ELOVL7	4.45e-04	27	40	2	25269881
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	SLCO4A1 SERINC3 SLC4A7	4.76e-04	132	40	3	26439863
Pubmed	Biosynthesis of triacylglycerols.	ELOVL2 ELOVL7	4.78e-04	28	40	2	8944226
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	SLC2A3 RYR1 RYR2	6.02e-04	143	40	3	20424473
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 RYR2	8.83e-04	38	40	2	30786075
Pubmed	Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.	SLC2A3 ELOVL7	9.79e-04	40	40	2	27760309
Pubmed	MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.	AREL1 ASB11	9.79e-04	40	40	2	30759391
Interaction	AVPR2 interactions	STARD3 TMED1 MFSD8 ELOVL2 ALG10	3.33e-06	123	38	5	int:AVPR2
Interaction	FMO4 interactions	RHBDD2 FMO1	7.23e-05	7	38	2	int:FMO4
Interaction	SLC22A9 interactions	MFSD8 FAM8A1 ELOVL2 ALG10	7.55e-05	120	38	4	int:SLC22A9
Interaction	CREB3 interactions	STARD3 TMED1 FMO1 FAM8A1 SLC2A3	8.20e-05	239	38	5	int:CREB3
Interaction	ABCA9 interactions	ABCA13 ABCA9	1.54e-04	10	38	2	int:ABCA9
Cytoband	16p12.3	TMC5 GPR139	4.08e-04	34	40	2	16p12.3
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	6.44e-06	3	27	2	287
GeneFamily	Transmembrane p24 trafficking proteins	TMED1 TMED3	9.59e-05	10	27	2	1064
GeneFamily	ATP binding cassette subfamily A	ABCA13 ABCA9	1.93e-04	14	27	2	805
GeneFamily	Solute carriers	SLCO4A1 SLC36A3 SLC4A7 SLC9C2 SLC2A3	2.63e-04	395	27	5	752
CoexpressionAtlas	DevelopingKidney_e15.5_early proxim tubul_emap-28005_k-means-cluster#4_top-relative-expression-ranked_1000	GPR137B FMO1 ELOVL2 RYR2 ELOVL7	1.04e-05	173	36	5	gudmap_developingKidney_e15.5_early proxim tubul_1000_k4
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_k-means-cluster#1_top-relative-expression-ranked_200	GPR137B FMO1 ELOVL7	5.27e-05	43	36	3	gudmap_kidney_P0_JuxtaGlom_Ren1_k1_200
CoexpressionAtlas	Myeloid Cells, GN.BM, CD11b+ Ly6-G+, Bone marrow, avg-4	ATP6V0A1 ABCA13 TLR8 SLC2A3 FPR1 ELOVL7	6.37e-05	415	36	6	GSM605846_500
CoexpressionAtlas	Myeloid Cells, GN.Arth.BM, CD11b+ Ly6-G+, Bone marrow, avg-3	ATP6V0A1 ABCA13 TLR8 SLC2A3 FPR1 ELOVL7	6.81e-05	420	36	6	GSM854303_500
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#4_top-relative-expression-ranked_500	GPR137B FMO1 ABCA13 ELOVL7	9.56e-05	142	36	4	gudmap_kidney_adult_RenalCortexMixed_Std_k4_500
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_200	GPR137B FMO1 COL12A1 ELOVL7	1.41e-04	157	36	4	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_200
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_200	GPR137B FMO1 COL12A1 ELOVL7	2.23e-04	177	36	4	gudmap_kidney_P0_JuxtaGlom_Ren1_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#2_top-relative-expression-ranked_1000	GPR137B SLCO4A1 ELOVL7	2.57e-04	73	36	3	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k2
ToppCell	droplet-Lung-30m-Hematologic-myeloid-neutrophil\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLCO4A1 SLC2A3 FPR1 ELOVL7	1.34e-05	162	40	4	9c9a63adb692651ea5a52cc77b02c5ce11d0ccea
ToppCell	droplet-Lung-30m-Hematologic-myeloid-neutrophil-neutrophil\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLCO4A1 SLC2A3 FPR1 ELOVL7	1.34e-05	162	40	4	1d29983b22f963b34e72cfd1eec328d2d7c4932f
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1 ELOVL7	1.44e-05	165	40	4	9acf03b5a20170721380045b5c268825e8f315dd
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SLCO4A1 TMC5 TSPAN5 NEMP2	1.81e-05	175	40	4	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.11e-05	182	40	4	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.11e-05	182	40	4	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 ABCA9 SLC2A3	2.35e-05	187	40	4	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FMO1 COL12A1 ABCA9 TSPAN5	2.50e-05	190	40	4	4f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR137B ITGA11 COL12A1 SLC2A3	2.60e-05	192	40	4	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 SLC4A7 ABCA9	2.60e-05	192	40	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FMO1 COL12A1 ABCA9 TSPAN5	2.66e-05	193	40	4	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FMO1 COL12A1 ABCA9 TSPAN5	2.66e-05	193	40	4	adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 SLC4A7 ABCA9	2.71e-05	194	40	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.77e-05	195	40	4	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 ABCA9 SLC2A3	2.77e-05	195	40	4	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.77e-05	195	40	4	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.77e-05	195	40	4	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.82e-05	196	40	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.82e-05	196	40	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ITGA11 FMO1 COL12A1 ABCA9	2.82e-05	196	40	4	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.88e-05	197	40	4	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR137B RYR1 FPR1 TMEM236	2.94e-05	198	40	4	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	COVID-19-kidney-Fibroblast-2\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 ABCA9 SLC2A3	2.94e-05	198	40	4	ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 ABCA9 SLC2A3	2.94e-05	198	40	4	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FMO1 COL12A1 TSPAN5 TMED3	3.00e-05	199	40	4	8de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA11 COL12A1 ABCA9 SLC2A3	3.00e-05	199	40	4	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR137B RYR1 FPR1 TMEM236	3.05e-05	200	40	4	ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCell	RA-15._Ventricular_Cardiomyocyte_III\|RA / Chamber and Cluster_Paper	RYR2 ALG10 NEMP2	2.35e-04	134	40	3	60ee3accc54108e5b9a0018f6aa8488dc39d5ade
ToppCell	RA-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	RYR2 ALG10 NEMP2	2.57e-04	138	40	3	5a713f24f633de463ef47ca37fbb2bb60c7fdb77
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 RYR1 ALG10	3.03e-04	146	40	3	1bf67a9416f52198931b912a31be4bab09fefd19
ToppCell	droplet-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 RYR1	3.09e-04	147	40	3	c031fad0a4e192019775809968e46da54a111d27
ToppCell	droplet-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 RYR1	3.09e-04	147	40	3	684e2d8d2f0516cf8b0dc53efa7efc3050bbf0d1
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCA9 TLR8 FPR1	3.15e-04	148	40	3	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 TSPAN5	3.28e-04	150	40	3	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 ADAM18 SLC2A3	3.28e-04	150	40	3	6e806a028c0519489151c181d9907e05289e27e0
ToppCell	Immune_cells-Neutrophils\|World / Lineage and Cell class	ABCA13 SLC2A3 FPR1	3.34e-04	151	40	3	056301bedb4285e797250b55d79ee1790a17516d
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 RYR1 ALG10	3.41e-04	152	40	3	b8aa62e3cf2b4c252db4bccfa75d881c4fa0a788
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ITGA11 COL12A1 ABCA9	3.47e-04	153	40	3	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ITGA11 COL12A1 ABCA9	3.47e-04	153	40	3	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	ITGA11 COL12A1 ABCA9	3.47e-04	153	40	3	2513edfae62a44e51d3556675a096723194c966c
ToppCell	facs-Spleen-nan-24m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	3.68e-04	156	40	3	034d4359359a44c205c6931f38a375271ac2752b
ToppCell	facs-Spleen-nan-24m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	3.68e-04	156	40	3	2a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCell	facs-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	3.68e-04	156	40	3	21267718d3a3dc19988663b6846aed8bb3eae836
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Myeloid-cardiac_mast_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A3 FPR1 ELOVL7	3.89e-04	159	40	3	766dfb9f9c0783e740a4fd395e99669310b33371
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FMO1 COL12A1 ABCA9	3.89e-04	159	40	3	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	ASB11 ABCA9 RYR2	3.89e-04	159	40	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 RYR1 FPR1	3.89e-04	159	40	3	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SERINC3 ABCA9 TLR8	3.89e-04	159	40	3	c0e55f25271f788c08fa4b95186501fc27b2ec39
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TLR8 FAM8A1 FPR1	4.03e-04	161	40	3	f5da03c426f3124ea302bd343b6bca81cafee858
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 TMC5	4.03e-04	161	40	3	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR8 FAM8A1 FPR1	4.11e-04	162	40	3	4e3bf16799c6552366d4c7e42b1328a05dcad7e7
ToppCell	Club-club-13\|World / Class top	FMO1 SLC4A7 SIDT1	4.11e-04	162	40	3	7d18f05a65ac715e62d610df9cc4a26539340dee
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 SLC2A3 FPR1	4.11e-04	162	40	3	dddf7a3901ae59e3494d8a6740db0fa15cc96d47
ToppCell	droplet-Lung-LUNG-30m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 SLC2A3 FPR1	4.11e-04	162	40	3	2a4e09545e9874519f0f56e81065104987d81cd6
ToppCell	CD8+_Memory_T_cell-FLU-1\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ATP6V0A1 SLC2A3 SIDT1	4.11e-04	162	40	3	76f39935763848ea6e7917b2f9f1432c543063d9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ABCA9 ELOVL2	4.18e-04	163	40	3	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ABCA9 ELOVL2	4.18e-04	163	40	3	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ITGA11 COL12A1 ABCA9	4.33e-04	165	40	3	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ITGA11 COL12A1 ABCA9	4.33e-04	165	40	3	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 ABCA9 RYR1	4.33e-04	165	40	3	2477b0f1a0ea26184cf3cc4a9ffcdfa825cbc615
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ABCA9 RYR2	4.33e-04	165	40	3	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ABCA9 RYR2	4.33e-04	165	40	3	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	droplet-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	4.33e-04	165	40	3	3cdb921f5b9facf04f81995d5641ac14ef3dbb6f
ToppCell	droplet-Marrow-BM-30m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A3 FPR1 ELOVL7	4.41e-04	166	40	3	019d365df44c3bbd88c1f4bdceb3de0ff76d3e8d
ToppCell	Dendritic_Cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	FPR1 TMEM236 SIDT1	4.41e-04	166	40	3	fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAKMIP3 SLC2A3 RYR2	4.49e-04	167	40	3	7cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAKMIP3 SLC2A3 RYR2	4.49e-04	167	40	3	bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAKMIP3 SLC2A3 RYR2	4.49e-04	167	40	3	e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 RYR1 FPR1	4.56e-04	168	40	3	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 FPR1	4.56e-04	168	40	3	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 RYR1 FPR1	4.56e-04	168	40	3	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 FPR1	4.56e-04	168	40	3	4ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	4.56e-04	168	40	3	c0ff30e2c47005514131a0866cf10a1c228128fc
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 FPR1	4.64e-04	169	40	3	454b92b9b67299a64278c010db033ca5b9d217a0
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC5 ABCA13 RYR2	4.64e-04	169	40	3	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	4.81e-04	171	40	3	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	4.81e-04	171	40	3	1701dedf0c18751db6c9fee3d93fff150ed0e17f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 JAKMIP3	4.81e-04	171	40	3	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AREL1 TLR8 SLC2A3	4.81e-04	171	40	3	5e93c76ee60f9d0590ebb140812653a5e1369417
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 FPR1	4.81e-04	171	40	3	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLCO4A1 RYR1 TMED3	4.89e-04	172	40	3	422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-Treg\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPAN5 SLC2A3 RYR1	4.89e-04	172	40	3	c74c1d47b133eb5d0f762a06e421252a76b4672b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 TMC5	4.89e-04	172	40	3	553701349444eb366df3c11f54bb093434f153c6
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 COL12A1 ABCA9	4.89e-04	172	40	3	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SLC2A3 ELOVL7	4.89e-04	172	40	3	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 COL12A1 TMC5	4.89e-04	172	40	3	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	droplet-Marrow-nan-3m-Hematologic-proerythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR8 SLC2A3 FPR1	4.89e-04	172	40	3	cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR8 ELOVL2 FPR1	4.89e-04	172	40	3	c32e6af9e2d29da47b5d870207b598cff11aef6c
ToppCell	PND07-28-samps-Myeloid-Macrophage-CD163+_Macrophage\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SERINC3 ATP6V0A1 ABCA9	4.89e-04	172	40	3	9a659442dc41bd2a4361a7e38a7ee37a39781667
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLCO4A1 RYR1 TMED3	4.89e-04	172	40	3	1abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR8 ELOVL2 FPR1	4.89e-04	172	40	3	1a0556c97fcba126126c22adea5235d977d41ebe
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SERINC3 ABCA9 TLR8	4.89e-04	172	40	3	f0e767a20d93e546ce278db67dbd779cc68af533
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLCO4A1 TSPAN5 NEMP2	5.06e-04	174	40	3	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	droplet-Marrow-nan-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A3 FPR1 ELOVL7	5.06e-04	174	40	3	4b749ac9f05776c0c56b74daca833bd0b5704299
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA11 COL12A1 RYR2	5.06e-04	174	40	3	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 TLR8 RYR2	5.23e-04	176	40	3	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC4A7 TMC5 SIDT1	5.23e-04	176	40	3	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 ABCA9 RYR2	5.31e-04	177	40	3	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ABCA9 SLC2A3	5.31e-04	177	40	3	b872ee91e01265b101b81bd304cf6b95d5419e68
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 ABCA9 RYR2	5.31e-04	177	40	3	db222faaecbe5600da39277243c4e7e764eb63c9
Computational	Ion channels.	CLCN6 RYR1 RYR2	3.23e-04	70	21	3	MODULE_316
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	9.02e-06	3	40	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	9.02e-06	3	40	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	9.02e-06	3	40	2	CID000127713
Drug	2-hydroxycarbazole	RYR1 RYR2	9.02e-06	3	40	2	CID000093551
Drug	aminodantrolene	RYR1 RYR2	9.02e-06	3	40	2	CID009570289
Drug	cis-diammineplatinum(II	RYR1 RYR2	9.02e-06	3	40	2	CID000159790
Drug	SC 38249	RYR1 RYR2	1.80e-05	4	40	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	1.80e-05	4	40	2	CID000035682
Drug	PCB74	RYR1 RYR2	1.80e-05	4	40	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	1.80e-05	4	40	2	CID006444275
Drug	Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ATP6V0A1 SLC4A7 CLCN6 ELOVL2 RYR2	2.26e-05	195	40	5	5416_DN
Drug	A 68930	RYR1 RYR2	3.00e-05	5	40	2	ctd:C065380
Drug	AC1O528X	RYR1 RYR2	4.49e-05	6	40	2	CID006475857
Drug	NSC114784	RYR1 RYR2	4.49e-05	6	40	2	CID000419425
Drug	MBED	RYR1 RYR2	4.49e-05	6	40	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR2	4.49e-05	6	40	2	CID000012008
Drug	Azumoleno	RYR1 RYR2	6.28e-05	7	40	2	CID000056259
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2	6.28e-05	7	40	2	CID009547999
Drug	Br2BAPTA	RYR1 RYR2	6.28e-05	7	40	2	CID003081001
Drug	lanthanum	LINC01587 CLCN6 RYR1 RYR2	9.42e-05	136	40	4	CID000023926
Drug	PCB 95	RYR1 RYR2	1.34e-04	10	40	2	CID000038012
Drug	R 478	RYR1 RYR2	1.64e-04	11	40	2	CID000084223
Drug	2,3,6,2',3',6'-hexachlorobiphenyl	RYR1 RYR2	1.64e-04	11	40	2	ctd:C010498
Drug	8-amino-cADPR	RYR1 RYR2	1.64e-04	11	40	2	CID003081323
Drug	PCB 66	RYR1 RYR2	1.64e-04	11	40	2	CID000036185
Drug	tectoridin	RYR1 RYR2	1.64e-04	11	40	2	CID005281810
Drug	vinylidene chloride	GPR137B SLCO4A1 FMO1 ATP6V0A1 SLC4A7 CLCN6 ABCA13 ELOVL2 ELOVL7 TMED3	1.78e-04	1475	40	10	ctd:C029297
Drug	iminodiacetic acid	MFSD8 ELOVL2 RYR1	1.85e-04	63	40	3	CID000008897
Drug	Ryanodine	RYR1 RYR2	1.96e-04	12	40	2	ctd:D012433
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	5.10e-06	3	39	2	DOID:8545 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	5.10e-06	3	39	2	DOID:3529 (implicated_via_orthology)
Disease	complement factor H-related protein 2 measurement	MFSD8 COL12A1	6.76e-04	29	39	2	EFO_0600055
Disease	smoking status measurement, diastolic blood pressure	SLC4A7 CLCN6 GPR139	1.22e-03	159	39	3	EFO_0006336, EFO_0006527
Disease	heart rate variability measurement, response to antipsychotic drug	COL12A1 JAKMIP3	1.70e-03	46	39	2	EFO_0008003, GO_0097332
Disease	systolic blood pressure, alcohol consumption measurement	SLC4A7 CLCN6	1.77e-03	47	39	2	EFO_0006335, EFO_0007878
Disease	response to lithium ion	SLCO4A1 COL12A1	2.51e-03	56	39	2	GO_0010226
Disease	chemokine (C-C motif) ligand 27 measurement	ITGA11 SLC4A7	3.88e-03	70	39	2	EFO_0008082
Disease	pulmonary hypertension (biomarker_via_orthology)	RYR1 RYR2	5.04e-03	80	39	2	DOID:6432 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFFLIVVIFSIVATD	ABCA9	1141	Q8IUA7
FLPFFIVFTTVIFKR	ADAM18	696	Q9Y3Q7
VDFTEQFLKTFFSLF	ABCA13	2261	Q86UQ4
QFFTIFFFLSVEFGK	LINC01587	16	Q99440
TMFATFFFFKLLIKV	ASB11	16	Q8WXH4
LFFFLFFVVSESFIL	OR8B8	101	Q15620
FFVTLFIFALFETII	MFSD8	276	Q8NHS3
DFKLFLVFVAGVFLF	NEMP2	151	A6NFY4
EEKFLFLFLFFSLAF	JAKMIP3	826	Q5VZ66
VAFRLDFEFSKSIFL	ITGA11	906	Q9UKX5
LFVDFFVRLFTQLKF	CLCN6	96	P51797
FKYILDFIAALVSAF	COL12A1	156	Q99715
FSKSVEFLDTIFFVL	ELOVL2	121	Q9NXB9
YFSKFIELLDTIFFV	ELOVL7	121	A1L3X0
FESFLKVFSFLALLV	FMO1	511	Q01740
SVVAFFFTIKFLFEL	AREL1	11	O15033
FFTIKFLFELAARVV	AREL1	16	O15033
TGFLITFLAFTFFKV	SLC2A3	436	P11169
AADILVLFFIVFVDF	GPR139	71	Q6DWJ6
VLFFIVFVDFLLEDF	GPR139	76	Q6DWJ6
VFDITFFFFVIVILL	RYR1	4916	P21817
FDITFFFFVIVILLA	RYR2	4846	Q92736
DFFILFFIKATIVLS	FAM8A1	256	Q9UBU6
LRTVLFSFYFKDFVA	GPR137B	91	O60478
LFFTTFFLSSFLKQF	SLC4A7	831	Q9Y6M7
FLCKFVFTIVDINLF	FPR1	96	P21462
KTFLLFFGTAIFTFE	SLC36A3	251	Q495N2
FKTSFFDIFVLAFFR	STARD3	91	Q14849
LVFIFVVIFFTFLSS	SLCO4A1	581	Q96BD0
VVNFITFFIFLNKTF	ALG10	446	Q5BKT4
VTAVILFFFTFFITT	TLR8	826	Q9NR97
FFTVIFAIFSAIIFL	RHBDD2	101	Q6NTF9
YVKSSLFSVFIFLSF	SIDT1	306	Q9NXL6
FVVSFSQVLLLKSFF	TMED3	191	Q9Y3Q3
AIFFFVFSLLMFKVK	SERINC3	106	Q13530
FSHISFIILFKVFLF	PRO0628	21	Q9UI54
FFFFTAFATLTVAIL	ATP6V0A1	776	Q93050
ENTFLLKFFSVFLGI	TSPAN5	86	P62079
LKFFSVFLGIIFFLE	TSPAN5	91	P62079
FLTFIFHIVFSEEFE	SLC9C2	596	Q5TAH2
FSTISEKLVFFELIF	TMED1	111	Q13445
VRAIKTMTSFIFFFF	TAS2R8	231	Q9NYW2
LLKFNIFSFILNFSF	TMC5	456	Q6UXY8
LIKFVVFELLEFAAF	TMEM236	6	Q5W0B7