Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase activity

RHBDD1 HABP2 TLL1

1.14e-03190223GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

RHBDD1 HABP2 TLL1

1.46e-03207223GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

RHBDD1 HABP2 TLL1

1.57e-03212223GO:0017171
GeneOntologyMolecularFunctionglycosaminoglycan binding

SEMA5A THBS2 HABP2

3.05e-03268223GO:0005539
DomainEGF_CA

THBS2 HABP2 TLL1

3.32e-04122213SM00179
DomainEGF-like_Ca-bd_dom

THBS2 HABP2 TLL1

3.48e-04124213IPR001881
DomainEGF

THBS2 HABP2 TLL1

3.65e-04126213PF00008
Domain-

TRAF7 EML4 SEMA5A ELP2

4.67e-043332142.130.10.10
DomainWD40/YVTN_repeat-like_dom

TRAF7 EML4 SEMA5A ELP2

4.78e-04335214IPR015943
DomainEGF_3

THBS2 HABP2 TLL1

2.21e-03235213PS50026
DomainEGF

THBS2 HABP2 TLL1

2.21e-03235213SM00181
DomainTSP_1

SEMA5A THBS2

2.26e-0363212PF00090
DomainTSP1

SEMA5A THBS2

2.40e-0365212SM00209
DomainTSP1_rpt

SEMA5A THBS2

2.40e-0365212IPR000884
DomainTSP1

SEMA5A THBS2

2.40e-0365212PS50092
DomainEGF-like_dom

THBS2 HABP2 TLL1

2.61e-03249213IPR000742
DomainEGF_1

THBS2 HABP2 TLL1

2.79e-03255213PS00022
DomainWD40

TRAF7 EML4 ELP2

2.91e-03259213PF00400
DomainEGF-like_CS

THBS2 HABP2 TLL1

2.98e-03261213IPR013032
DomainEGF_2

THBS2 HABP2 TLL1

3.11e-03265213PS01186
DomainWD40

TRAF7 EML4 ELP2

3.21e-03268213SM00320
DomainWD40_repeat

TRAF7 EML4 ELP2

3.35e-03272213IPR001680
DomainWD_REPEATS_1

TRAF7 EML4 ELP2

3.56e-03278213PS00678
DomainWD_REPEATS_2

TRAF7 EML4 ELP2

3.59e-03279213PS50082
DomainWD_REPEATS_REGION

TRAF7 EML4 ELP2

3.59e-03279213PS50294
DomainEGF_CA

THBS2 TLL1

4.16e-0386212PF07645
DomainWD40_repeat_dom

TRAF7 EML4 ELP2

4.28e-03297213IPR017986
DomainWD40_repeat_CS

TRAF7 EML4

1.44e-02164212IPR019775
Pubmed

Novel association strategy with copy number variation for identifying new risk Loci of human diseases.

TNNI3K PDPR

2.75e-051223220808825
Pubmed

Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.

TRAF7 THBS2

2.90e-043823217543594
Cytoband21q22.3

TRAPPC10 PRDM15

1.88e-0312823221q22.3
GeneFamilyWD repeat domain containing

TRAF7 EML4 ELP2

2.45e-03262193362
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 SPTB

1.94e-02206192682
GeneFamilyRing finger proteins

RNF34 TRAF7

3.32e-0227519258
CoexpressionGSE34156_UNTREATED_VS_24H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_DN

ELP2 ZNF451 IFNA8 PDPR

2.40e-05196234M8685
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNF34 TTC27 AKR1C1 THBS2

2.31e-061852349878392d79734ab5bb977d7f4f5e2e079b9a5353
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 SEMA5A AKR1C1 THBS2

2.78e-0619423470185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TNNI3K THBS2 SPTB

4.88e-05139233fe1657ef9aeda7c530dc7febcd3dcd0e1d5f8a48
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF451 SPTB PDPR

7.01e-05157233370f44047ef438b8f1124c2c2761c150c0d8c57f
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

SEMA5A SHISA5 PTPRQ

9.03e-051712333965ced4be6db14265a90673502fceee425837ca
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.02e-04178233edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.03e-041792337394e77e665bf16d3733df91bb12907be460ab44
ToppCellIPF-Epithelial-Mesothelial|IPF / Disease state, Lineage and Cell class

SEMA5A THBS2 PTPRQ

1.05e-041802331fa54bf4dba72866b2295639d991af639341bc08
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.07e-041812335bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.07e-041812338e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.10e-041832337c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.10e-04183233612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.10e-04183233eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellIPF-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

SEMA5A THBS2 PTPRQ

1.10e-041832337df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.18e-0418723324c2a3962da364e46e98abeab5f8234376fa26bb
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK11 TLL1 PTPRQ

1.18e-041872338e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK11 TLL1 PTPRQ

1.20e-041882339655a4c47b644a870017d349b99063e17dbae572
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.23e-0419023392710caaff05123cf8e909319d7ac441d9b31a66
ToppCell15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

DOCK11 THBS2 PTPRQ

1.23e-04190233b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCellControl-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

DOCK11 EML4 AKR1C1

1.25e-04191233a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 SEMA5A TLL1

1.25e-041912331cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.27e-04192233ef0aba777072429a6ab7dcfcc305673975946580
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK11 SEMA5A SPTB

1.27e-0419223355f95454399fd533df75db06584eaa48d6ee3830
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A SPTB PTPRQ

1.29e-041932333eaa0461618582a1754400624350d269d24e750a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 SEMA5A AKR1C1

1.29e-04193233ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOCK11 AKR1C1 TLL1

1.37e-04197233143607d195c8aa2b94d995af0b2ef38582565611
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A AKR1C1 THBS2

1.39e-04198233be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EML4 SEMA5A AKR1C1

1.41e-0419923332bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SEMA5A THBS2 TLL1

1.44e-04200233747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SEMA5A THBS2 TLL1

1.44e-04200233de1d193f773f4e2927baa6fc38d29754b015c6e6
Diseaseintellectual disability (implicated_via_orthology)

ELP2 POGZ

1.42e-0375222DOID:1059 (implicated_via_orthology)
Diseasebilirubin measurement

TTC27 TLL1 SPTB

4.16e-03442223EFO_0004570
Diseasehemorrhoid

TTC27 THBS2

5.33e-03147222EFO_0009552
Diseaseautism spectrum disorder (implicated_via_orthology)

ELP2 POGZ

5.69e-03152222DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
WFDIVESEVKCCKEA

PDPR

506

Q8NCN5
CKEWESEECVEYQKI

PTPRQ

1516

Q9UMZ3
VTNDKVKWEYCDVSA

HABP2

261

Q14520
VKECIKTYSTDWHVV

DOCK11

101

Q5JSL3
CVSNKAVYSLECKWA

DHRS4-AS1

31

Q9P1J3
EKKYSSCAWEVVRAE

IFNA8

156

P32881
SDCKDIDWTTYTCVL

EML4

761

Q9HC35
KKVVVWGECDSTDDC

ELP2

691

Q6IA86
SSCLSVEKCYQQKDW

RHBDD1

51

Q8TEB9
KECVWKITVSESYHV

TLL1

486

O43897
WTCSVCDKKYVTEYM

PRDM15

1196

P57071
YESTTKCKICEWAFE

POGZ

556

Q7Z3K3
YCCSDVLKKFVWSEE

SHISA5

56

Q8N114
AVEWECDEATKKACY

SEMA5A

91

Q13591
TVDLCATWEAVEKCK

AKR1C1

141

Q04828
CVQKEKSVVKTWFCE

ZNF451

461

Q9Y4E5
VNYSGCCEKWELVEK

RNF34

281

Q969K3
SDKTIKVWDTCTTYK

TRAF7

416

Q6Q0C0
KVWDTCTTYKCQKTL

TRAF7

421

Q6Q0C0
VHNYCVDCEETSKWI

SPTB

956

P11277
ETWVVDSCTTCTCKK

THBS2

331

P35442
WTECCDTEVYKATVK

TRAPPC10

91

P48553
YKCDTQSNCWEKDIT

TTC27

741

Q6P3X3
TCTDEWKKKVSESYV

TNNI3K

11

Q59H18