Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA4 ERCC6L DHX40 RFC2 MDN1 SLFN13 ABCE1 CHTF18 SLFN11 KIF5C KIF25	6.18e-05	441	118	11	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA4 ERCC6L DHX40 RFC2 MDN1 SLFN13 ABCE1 CHTF18 SLFN11 KIF5C ACSS3 KIF25	2.82e-04	614	118	12	GO:0140657
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GAS6 BIRC2 SERPINB9	3.72e-04	24	118	3	GO:0043027
GeneOntologyBiologicalProcess	cellular process involved in reproduction in multicellular organism	TCP11X1 TCP11X2 STRBP PIWIL1 LYZL6 RNF17 GSK3B GMCL1 TRIM28 CHTF18 TDRD6 NANOS1 ROPN1 ICA1L KNL1	3.41e-07	527	118	15	GO:0022412
GeneOntologyBiologicalProcess	germ cell development	TCP11X1 TCP11X2 STRBP PIWIL1 RNF17 GSK3B GMCL1 TRIM28 CHTF18 TDRD6 NANOS1 ROPN1 ICA1L KNL1	6.81e-07	482	118	14	GO:0007281
Domain	ARM-type_fold	TTI2 INTS1 IPO4 DNAAF5 URB1 UNC45B LTN1 NUP188 HEATR5B BRAT1 FMNL1	1.10e-05	339	119	11	IPR016024
Domain	Leu-rich_rpt	FBXL13 PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 CD14 SLIT1 TBCE	6.01e-05	271	119	9	IPR001611
Domain	LRR_1	FBXL13 PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 CD14 SLIT1	8.08e-05	219	119	8	PF00560
Domain	NHR2	RUNX1T1 CBFA2T3	1.20e-04	3	119	2	PF08788
Domain	DUF2075	SLFN13 SLFN11	1.20e-04	3	119	2	PF09848
Domain	CBFA2T1/2/3	RUNX1T1 CBFA2T3	1.20e-04	3	119	2	IPR013289
Domain	NHR2	RUNX1T1 CBFA2T3	1.20e-04	3	119	2	IPR014896
Domain	DUF2075	SLFN13 SLFN11	1.20e-04	3	119	2	IPR018647
Domain	-	FBXL13 PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 CD14 SLIT1 TBCE	2.16e-04	321	119	9	3.80.10.10
Domain	L_dom-like	FBXL13 PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 CD14 SLIT1 TBCE	2.54e-04	328	119	9	IPR032675
Domain	TAFH	RUNX1T1 CBFA2T3	3.98e-04	5	119	2	SM00549
Domain	TAFH_NHR1	RUNX1T1 CBFA2T3	3.98e-04	5	119	2	IPR003894
Domain	TAFH	RUNX1T1 CBFA2T3	3.98e-04	5	119	2	PS51119
Domain	TAFH	RUNX1T1 CBFA2T3	3.98e-04	5	119	2	PF07531
Domain	-	RNF17 TDRD6	5.94e-04	6	119	2	2.40.50.90
Domain	Staphylococal_nuclease_OB-fold	RNF17 TDRD6	5.94e-04	6	119	2	IPR016071
Domain	LRR_8	PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 SLIT1	7.97e-04	171	119	6	PF13855
Domain	AlbA_2	SLFN13 SLFN11	8.28e-04	7	119	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	8.28e-04	7	119	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	8.28e-04	7	119	2	IPR007421
Domain	LRR_TYP	PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 SLIT1	9.54e-04	177	119	6	SM00369
Domain	Leu-rich_rpt_typical-subtyp	PIDD1 LRRIQ4 LRRC30 LRRC8D LRCH3 SLIT1	9.54e-04	177	119	6	IPR003591
Domain	HEAT_REPEAT	IPO4 DNAAF5 HEATR5B BRAT1	1.04e-03	70	119	4	PS50077
Domain	BIR	BIRC2 BIRC6	1.10e-03	8	119	2	PF00653
Domain	BIR_REPEAT_2	BIRC2 BIRC6	1.10e-03	8	119	2	PS50143
Domain	BIR	BIRC2 BIRC6	1.10e-03	8	119	2	SM00238
Domain	-	BIRC2 BIRC6	1.10e-03	8	119	2	1.10.1170.10
Domain	BIR_rpt	BIRC2 BIRC6	1.10e-03	8	119	2	IPR001370
Domain	BIR_REPEAT_1	BIRC2 BIRC6	1.10e-03	8	119	2	PS01282
Domain	ARM-like	TTI2 IPO4 DNAAF5 UNC45B LTN1 HEATR5B BRAT1	1.73e-03	270	119	7	IPR011989
Domain	ZU5	UNC5B PIDD1	1.75e-03	10	119	2	PS51145
Domain	LRR	PIDD1 LRRIQ4 LRRC30 LRRC8D CD14 SLIT1	1.83e-03	201	119	6	PS51450
Domain	-	ERCC6L CNOT10 RMDN2 UNC45B PEX5 ZC3H7B	2.12e-03	207	119	6	1.25.40.10
Domain	AAA	ABCA4 RFC2 MDN1 ABCE1 CHTF18	2.30e-03	144	119	5	SM00382
Domain	AAA+_ATPase	ABCA4 RFC2 MDN1 ABCE1 CHTF18	2.30e-03	144	119	5	IPR003593
Domain	ZU5	UNC5B PIDD1	2.55e-03	12	119	2	PF00791
Domain	ZU5_dom	UNC5B PIDD1	2.55e-03	12	119	2	IPR000906
Domain	TPR_1	CNOT10 UNC45B PEX5 ZC3H7B	2.63e-03	90	119	4	IPR001440
Domain	TPR_1	CNOT10 UNC45B PEX5 ZC3H7B	2.63e-03	90	119	4	PF00515
Domain	P-loop_NTPase	ABCA4 ERCC6L DHX40 RFC2 MDN1 RAB34 HNRNPUL2 SLFN13 ABCE1 CHTF18 SLFN11 KIF5C KIF25	2.93e-03	848	119	13	IPR027417
Domain	-	UNC5B PIDD1 BIRC2 CFLAR	2.96e-03	93	119	4	1.10.533.10
Domain	TUDOR	RNF17 TDRD6	3.48e-03	14	119	2	PF00567
Domain	HEAT	IPO4 DNAAF5 BRAT1	3.54e-03	48	119	3	PF02985
Domain	DEATH-like_dom	UNC5B PIDD1 BIRC2 CFLAR	3.70e-03	99	119	4	IPR011029
Domain	TPR-like_helical_dom	ERCC6L CNOT10 RMDN2 UNC45B PEX5 ZC3H7B	3.80e-03	233	119	6	IPR011990
Domain	Znf_RING-CH	MARCHF5 LTN1	5.14e-03	17	119	2	IPR011016
Domain	RINGv	MARCHF5 LTN1	5.14e-03	17	119	2	SM00744
Domain	HEAT_type_2	IPO4 DNAAF5	5.14e-03	17	119	2	IPR021133
Domain	HEAT	IPO4 DNAAF5 BRAT1	6.03e-03	58	119	3	IPR000357
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX40 IPO4 RFC2 SERPINH1 BIRC6 GSK3B SART1 URB1 ARHGEF40 TBC1D4 ARAP3 MDN1 RAB34 HNRNPUL2 P4HB ABCE1 TRIM28 CHTF18 LTN1 WDR13 ANKRD52 FTSJ3	2.53e-09	1353	124	22	29467282
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	IRF2BP1 STRBP INTS1 RFC2 SERPINH1 SART1 URB1 EFNB1 MDN1 PTPRF HNRNPUL2 P4HB TRIM28 PEX5 NUP188 HEATR5B FTSJ3	1.48e-07	1024	124	17	24711643
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	STRBP INTS1 IPO4 SERPINH1 BIRC6 SART1 URB1 MDN1 P4HB ABCE1 NUP188 ANKRD52 FTSJ3	6.53e-07	653	124	13	22586326
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	ERCC6L CNOT10 ALS2 IPO4 RUNX1T1 GSK3B CFLAR DNAAF5 TBC1D4 SARS2 P4HB TRIM28 BARHL1 ASB3 TMEM102 NUP188 KIF5C FTSJ3	7.30e-07	1284	124	18	17353931
Pubmed	Defining the membrane proteome of NK cells.	ERCC6L CNOT10 INTS1 IPO4 PEX11B BIRC6 LRRC8D SERPINB9 MDN1 HNRNPUL2 ABCE1 CHTF18 MARCHF5 NUP188 HEATR5B BRAT1 FMNL1	9.19e-07	1168	124	17	19946888
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLXNA3 INTS1 BIRC6 CCDC142 URB1 ARHGEF40 SARS2 ARAP3 MDN1 PTPRF TRIM28 SAC3D1 ZFYVE26 NUP188 ZC3H7B BRAT1	2.11e-06	1105	124	16	35748872
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN13 UNC45B SLFN11	2.45e-06	8	124	3	19619625
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DHX40 IPO4 DNAAF5 PTPDC1 ARAP3 RAB34 PTPRF HNRNPUL2 P4HB ABCE1 TRIM28 LTN1 NUP188 ANKRD52	1.04e-05	974	124	14	28675297
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PLCXD1 GAS6 BIRC2 RFC2 SART1 ARHGEF40 TRIM28 LTN1 PEX5 SLFN11 NUP188 WDR13 ANKRD52 KNL1 FTSJ3	1.09e-05	1116	124	15	31753913
Pubmed	Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.	CLDN6 CLDN9	1.26e-05	2	124	2	17804490
Pubmed	Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.	CLDN6 CLDN9	1.26e-05	2	124	2	23864633
Pubmed	RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.	PIWIL1 RNF17	1.26e-05	2	124	2	26115953
Pubmed	Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma.	GSK3B CFLAR	1.26e-05	2	124	2	29445085
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	1.26e-05	2	124	2	37833372
Pubmed	piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis.	PIWIL1 TDRD6	1.26e-05	2	124	2	38491008
Pubmed	ETO-2, a new member of the ETO-family of nuclear proteins.	RUNX1T1 CBFA2T3	1.26e-05	2	124	2	10022820
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	1.26e-05	2	124	2	29563550
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	STRBP INTS1 IPO4 GSK3B SART1 SERPINB9 MDN1 ZC3H7B BRAT1	1.43e-05	400	124	9	35013556
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	STRBP DHX40 BIRC2 BIRC6 SARS2 MDN1 P4HB CHTF18 KIF5C ANKRD52	1.68e-05	515	124	10	31617661
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ABCA4 IRF2BP1 ERCC6L STRBP DHX40 MDN1 ABCE1 SLFN11 ANKRD52 KNL1 ACSS3	1.89e-05	638	124	11	31182584
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	PLXNA3 NEUROD2 EFNB1 SLIT1	2.44e-05	47	124	4	35462405
Pubmed	Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression.	PIWIL1 RNF17 TDRD6	2.90e-05	17	124	3	19345099
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ERCC6L TTI2 IPO4 PEX11B SERPINH1 GSK3B DNAAF5 URB1 ARHGEF40 PTPRF NUP188 HEATR5B BRAT1	3.35e-05	942	124	13	31073040
Pubmed	A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.	SART1 CFLAR	3.77e-05	3	124	2	22027693
Pubmed	CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions.	RUNX1T1 CBFA2T3	3.77e-05	3	124	2	38243303
Pubmed	Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate.	CLDN6 CLDN9	3.77e-05	3	124	2	20874001
Pubmed	CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.	RUNX1T1 CBFA2T3	3.77e-05	3	124	2	9790752
Pubmed	The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus.	CLDN6 CLDN9	3.77e-05	3	124	2	18234789
Pubmed	hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.	GSK3B CFLAR	3.77e-05	3	124	2	26972480
Pubmed	Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.	CLDN6 CLDN9	3.77e-05	3	124	2	16774906
Pubmed	Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas.	CLDN6 CLDN9	3.77e-05	3	124	2	19960275
Pubmed	GSK3beta and PKCzeta function in centrosome localization and process stabilization during Slit-mediated neuronal repolarization.	GSK3B SLIT1	3.77e-05	3	124	2	16682216
Pubmed	Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.	PLXNA3 CBFA2T3	3.77e-05	3	124	2	20138877
Pubmed	miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells.	AVEN BIRC6	3.77e-05	3	124	2	27388765
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	3.77e-05	3	124	2	38875319
Pubmed	Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.	UNC5B BARHL1 SLIT1	4.11e-05	19	124	3	23307742
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	IRF2BP1 MDN1 PTPRF P4HB TRIM28 CHTF18 BRAT1	4.52e-05	262	124	7	36880596
Pubmed	PIWIL1 suppresses circadian rhythms through GSK3β-induced phosphorylation and degradation of CLOCK and BMAL1 in cancer cells.	PIWIL1 GSK3B	7.53e-05	4	124	2	31099187
Pubmed	Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets.	GSK3B CREB3L3	7.53e-05	4	124	2	26108621
Pubmed	IAPs: more than just inhibitors of apoptosis proteins.	BIRC2 BIRC6	7.53e-05	4	124	2	18414036
Pubmed	STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.	STK17B GSK3B	7.53e-05	4	124	2	29445189
Pubmed	TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.	CLDN6 CLDN9	7.53e-05	4	124	2	29031421
Pubmed	ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.	RUNX1T1 CBFA2T3	7.53e-05	4	124	2	16966434
Pubmed	TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.	GSK3B TRIM28	7.53e-05	4	124	2	30042493
Pubmed	Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments.	CLDN6 CLDN9	7.53e-05	4	124	2	11912246
Pubmed	Variants of human CLDN9 cause mild to profound hearing loss.	CLDN6 CLDN9	7.53e-05	4	124	2	34265170
Pubmed	Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.	RUNX1T1 CBFA2T3	7.53e-05	4	124	2	14703694
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	LRCH3 ARHGEF40 P4HB ANKRD52 FTSJ3	8.85e-05	125	124	5	29467281
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ERCC6L STRBP DHX40 ARHGEF40 ARAP3 HNRNPUL2 ABCE1 CHTF18 ASB3 ZC3H7B	1.17e-04	650	124	10	38777146
Pubmed	Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.	BIRC2 BIRC6	1.25e-04	5	124	2	20957035
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	1.25e-04	5	124	2	18355440
Pubmed	RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.	RNF17 TDRD6	1.25e-04	5	124	2	16093322
Pubmed	Regional expression of MTG genes in the developing mouse central nervous system.	RUNX1T1 CBFA2T3	1.25e-04	5	124	2	19618476
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	1.25e-04	5	124	2	29528433
Pubmed	Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.	RUNX1T1 CBFA2T3	1.25e-04	5	124	2	18586123
Pubmed	Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells.	RUNX1T1 GSK3B	1.25e-04	5	124	2	34369622
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	1.25e-04	5	124	2	24089532
Pubmed	Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.	RUNX1T1 CBFA2T3	1.25e-04	5	124	2	18039847
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	INTS1 IPO4 RFC2 SERPINH1 BIRC6 URB1 SARS2 MDN1 P4HB ABCE1 TRIM28 CHTF18 NUP188 BRAT1	1.62e-04	1257	124	14	37317656
Pubmed	Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.	RUNX1T1 CBFA2T3	1.87e-04	6	124	2	23251453
Pubmed	Opposing roles for 53BP1 during homologous recombination.	TRIM28 NHEJ1	1.87e-04	6	124	2	23969417
Pubmed	TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages.	GAS6 GSK3B	1.87e-04	6	124	2	20103767
Pubmed	Purification and identification of endogenous polySUMO conjugates.	SART1 TRIM28	1.87e-04	6	124	2	21252943
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN13 SLFN11	1.87e-04	6	124	2	9846487
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IRF2BP1 STRBP TTI2 IPO4 RFC2 SERPINH1 LRCH3 DNAAF5 URB1 MDN1 HNRNPUL2 TRIM28 LTN1 NUP188 CCDC85B	1.94e-04	1440	124	15	30833792
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STRBP IPO4 RFC2 BIRC6 ABCE1 TRIM28 LTN1 NUP188 KIF5C ZC3H7B	2.23e-04	704	124	10	29955894
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	STRBP DHX40 IPO4 SERPINH1 SART1 URB1 MDN1 P4HB TRIM28 BRAT1 KNL1 FTSJ3	2.25e-04	989	124	12	36424410
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	LRCH3 SART1 URB1 MDN1 HNRNPUL2 NUP188 FTSJ3	2.27e-04	340	124	7	29478914
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	IRF2BP1 RFC2 PEX11B GSK3B DNAAF5 SERPINB9 RAB34 NUP188	2.44e-04	457	124	8	32344865
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	BIRC2 PTPRF	2.62e-04	7	124	2	29073098
Pubmed	The inhibitors of apoptosis (IAPs) and their emerging role in cancer.	BIRC2 BIRC6	2.62e-04	7	124	2	9916987
Pubmed	IAP family proteins--suppressors of apoptosis.	BIRC2 BIRC6	2.62e-04	7	124	2	9990849
Pubmed	The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.	RUNX1T1 CBFA2T3	2.62e-04	7	124	2	12242670
Pubmed	The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.	BIRC2 BIRC6	2.62e-04	7	124	2	15640352
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN13 SLFN11	2.62e-04	7	124	2	15351786
Pubmed	Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.	RFC2 CHTF18	2.62e-04	7	124	2	18499658
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	IRF2BP1 CNOT10 FANCL IPO4 LRCH3 SART1 DNAAF5 PTPDC1 TEKT2 TBC1D4 P4HB TMEM102 KIF5C TBCE	2.70e-04	1321	124	14	27173435
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	BIRC2 RFC2 SERPINH1 SART1 MDN1 RAB34 HNRNPUL2 P4HB TRIM28 NUP188	2.82e-04	725	124	10	27025967
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	IRF2BP1 INTS1 RFC2 SERPINH1 SART1 MDN1 HNRNPUL2 ABCE1 TRIM28 CHTF18 NHEJ1 BRAT1	2.83e-04	1014	124	12	32416067
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TTI2 INTS1 PIDD1 BIRC6 URB1 NEUROD2 TBC1D4 MDN1 ABCE1 NUP188	3.17e-04	736	124	10	29676528
Pubmed	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.	RUNX1T1 CBFA2T3	3.48e-04	8	124	2	11533236
Pubmed	Distinct subdomain organization and molecular composition of a tight junction with adherens junction features.	CLDN6 CLDN9	3.48e-04	8	124	2	17130295
Pubmed	Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.	PIWIL1 TDRD6	3.48e-04	8	124	2	28254886
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	INTS1 PEX11B SERPINH1 SART1 TBC1D4 EFNB1 RAB34 PTPRF P4HB TRIM28 MARCHF5 NUP188 BRAT1	3.75e-04	1203	124	13	29180619
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	IRF2BP1 TRIM28 MARCHF5 LTN1	3.81e-04	95	124	4	29643511
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	STRBP RFC2 BIRC6 SART1 URB1 MDN1 HNRNPUL2 TRIM28 ZC3H7B FTSJ3	4.04e-04	759	124	10	35915203
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	STK17B GAS6 INTS1 BIRC2 SERPINH1 GSK3B ARHGEF40 ABCE1 TRIM28 NUP188 KNL1	4.28e-04	910	124	11	36736316
Pubmed	Identification of an antiapoptotic protein complex at death receptors.	BIRC2 GSK3B	4.47e-04	9	124	2	18846110
Pubmed	The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis.	CFLAR TRIM28	4.47e-04	9	124	2	35044632
Pubmed	XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3.	BIRC2 GSK3B	4.47e-04	9	124	2	19698783
Pubmed	Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.	PEX11B PEX5	4.47e-04	9	124	2	12096124
Pubmed	NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.	TCP11X2 NXF3	4.47e-04	9	124	2	11566096
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	IPO4 GSK3B TBC1D4 HNRNPUL2 TRIM28 BRAT1 ANKRD52 FTSJ3	4.61e-04	503	124	8	16964243
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ERCC6L IPO4 SERPINH1 DNAAF5 TBC1D4 MDN1 P4HB TRIM28 NUP188	4.86e-04	638	124	9	33239621
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	TTI2 INTS1 RFC2 SART1 HNRNPUL2 TRIM28 SLFN11	5.17e-04	390	124	7	17643375
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	TTI2 IPO4 DNAAF5 P4HB LTN1	5.19e-04	183	124	5	23956138
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 MDN1 CHTF18 LTN1	5.37e-04	104	124	4	31240132
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	RFC2 URB1 HNRNPUL2 FTSJ3	5.37e-04	104	124	4	26167872
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	IRF2BP1 INTS1 IPO4 MDN1 SLFN11 KNL1	5.41e-04	282	124	6	23667531
Pubmed	Claudin association with CD81 defines hepatitis C virus entry.	CLDN6 CLDN9	5.57e-04	10	124	2	20375010
Interaction	PEX3 interactions	IPO4 PEX11B SERPINH1 BIRC6 MDN1 P4HB MARCHF5 PEX5 NUP188	7.48e-07	171	118	9	int:PEX3
Interaction	UBXN6 interactions	ERCC6L GSK3B DNAAF5 TBC1D4 ARAP3 MDN1 CHTF18 ZC3H7B BRAT1 GPAT2 KNL1	3.34e-06	325	118	11	int:UBXN6
Interaction	NPTN interactions	TTI2 INTS1 IPO4 DNAAF5 MDN1 LTN1 ZFYVE26 HEATR5B BRAT1 DOP1A	5.58e-06	278	118	10	int:NPTN
Interaction	GPR17 interactions	STK17B TTI2 INTS1 DNAAF5 URB1 MDN1 LTN1 HEATR5B BRAT1 DOP1A	6.53e-06	283	118	10	int:GPR17
Interaction	NPAS1 interactions	IRF2BP1 INTS1 DNAAF5 ARAP3 CHTF18 PEX5 BRAT1 GPAT2 KNL1	1.42e-05	245	118	9	int:NPAS1
Interaction	PLBD1 interactions	DNAAF5 GMCL1 ARAP3 CHTF18 BRAT1 GPAT2	1.68e-05	92	118	6	int:PLBD1
Interaction	FLT3 interactions	FBXL13 STRBP PLCXD1 PCDHGA2 IPO4 SERPINH1 DNAAF5 URB1 MDN1 NUP188	1.80e-05	318	118	10	int:FLT3
Interaction	RFXANK interactions	IRF2BP1 DNAAF5 ARAP3 TRIM28 CHTF18 BRAT1 KNL1	2.44e-05	146	118	7	int:RFXANK
Interaction	HNRNPCL2 interactions	IRF2BP1 ERCC6L STRBP RFC2 URB1 ARHGEF40 CHTF18 ZC3H7B BRAT1	3.42e-05	274	118	9	int:HNRNPCL2
Interaction	AKAP1 interactions	PEX11B RMDN2 SERPINH1 BIRC6 MDN1 RAB34 ERAP2 P4HB ABCE1 MARCHF5 NUP188 GPAT2	3.98e-05	503	118	12	int:AKAP1
Interaction	EEF1AKMT3 interactions	IRF2BP1 ERCC6L CNOT10 DNAAF5 ARAP3 MDN1 CHTF18 ZC3H7B BRAT1 GPAT2	5.65e-05	364	118	10	int:EEF1AKMT3
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	LYZL6 NEUROD2 SLFN13 UNC45B SLFN11	5.56e-05	149	124	5	chr17q12
Cytoband	7p22.3	INTS1 DNAAF5 BRAT1	1.08e-04	34	124	3	7p22.3
Cytoband	17q12	NEUROD2 SLFN13 UNC45B SLFN11	1.57e-04	99	124	4	17q12
Cytoband	2p22.2	RMDN2 HEATR5B	7.43e-04	15	124	2	2p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	TCP11X1 TCP11X2 NXF3 FRMPD3	1.26e-03	172	124	4	chrXq22
GeneFamily	Schlafen family	SLFN13 SLFN11	4.10e-04	7	81	2	1110
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	BIRC2 BIRC6	5.45e-04	8	81	2	419
GeneFamily	Ankyrin repeat domain containing	ANKRD39 ARAP3 ASB16 ASB3 TRPV4 ANKRD52	7.59e-04	242	81	6	403
GeneFamily	AAA ATPases	RFC2 MDN1 CHTF18	1.73e-03	53	81	3	413
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	L3MBTL1 NANOS1	2.28e-03	16	81	2	66
GeneFamily	AAA ATPases\|Peroxins	PEX11B PEX5	2.28e-03	16	81	2	957
GeneFamily	Zinc fingers MYND-type	RUNX1T1 CBFA2T3	3.94e-03	21	81	2	87
GeneFamily	Claudins	CLDN6 CLDN9	4.72e-03	23	81	2	488
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	AVEN ERCC6L STRBP STK17B ALS2 RNF17 URB1 MDN1 NUP188	2.07e-05	266	120	9	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	UNC5B SERPINB9 TBC1D4 NXF3 NANOS1 ACSS3	5.75e-06	161	123	6	22fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTI2 DOK3 CCNG2 ARHGEF40 SERPINB9 RAB34	1.12e-05	181	123	6	2b9b460239d67fd480cee60820cdb306109d3567
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L RFC2 CHTF18 SAC3D1 CREB3L3 KNL1	1.23e-05	184	123	6	bba0138c8f7e3645a688b9a4d12f6f2134ee2c08
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L RFC2 CHTF18 SAC3D1 CREB3L3 KNL1	1.23e-05	184	123	6	eaef1dcde60ba14e2c7fd699d01c225487256d82
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L RFC2 CHTF18 SAC3D1 CREB3L3 KNL1	1.23e-05	184	123	6	fa73738350654066d7f9ebf78359e20ee6cbdd98
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STRBP PHYHIP NEUROD2 TBC1D4 BARHL1 KIF5C	1.27e-05	185	123	6	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	TCGA-Kidney-Primary_Tumor\|TCGA-Kidney / Sample_Type by Project: Shred V9	DOK3 RFC2 SERPINH1 P4HB SLFN13 FMNL1	1.48e-05	190	123	6	773c4575d22483d89a54c8db0e09905deed0d088
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	DOK3 RFC2 SERPINH1 P4HB SLFN13 FMNL1	1.48e-05	190	123	6	e3696e7542424c03d0a41136b10729a3dd09549a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5B GAS6 EFNB1 ARAP3 NXF3 CCDC85B	1.76e-05	196	123	6	d323f7dc41380446e5967c69832bea88351a9331
Disease	docosahexaenoic acid measurement, sex interaction measurement	LRRC30 NHEJ1	3.12e-04	7	115	2	EFO_0007761, EFO_0008343
Disease	C-C motif chemokine 16 measurement	LYZL6 SLFN11	9.69e-04	12	115	2	EFO_0008044
Disease	Infantile Refsum Disease (disorder)	PEX11B PEX5	1.14e-03	13	115	2	C0282527
Disease	Peroxisome biogenesis disorders	PEX11B PEX5	1.53e-03	15	115	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX11B PEX5	1.53e-03	15	115	2	C0282525
Disease	Zellweger Syndrome	PEX11B PEX5	1.74e-03	16	115	2	C0043459
Disease	attention deficit hyperactivity disorder, Cannabis use	RUNX1T1 PTPRF	2.21e-03	18	115	2	EFO_0003888, EFO_0007585
Disease	activities of daily living score measurement	PIWIL1 NANOS1	3.01e-03	21	115	2	EFO_0008451

Protein segments in the cluster

Peptide	Gene	Start	Entry
RATPQALLLDALCLL	CHTF18	751	Q8WVB6
AFQVLLQPLACVLKA	BRAT1	316	Q6PJG6
PSAAQAPRLALKCLA	ARHGEF40	111	Q8TER5
LLQALCAAVARPNLL	ARAP3	616	Q8WWN8
ALCEAARRASKALLP	AQP12A	16	Q8IXF9
LALKQARCSPNICLR	ANTXRL	521	A6NF34
CRKDLNGILLLDTAL	BIRC6	136	Q9NR09
LRENLALKELCLALG	CCDC85B	131	Q15834
DLSPRCNLTVKDLLL	CREB3L3	171	Q68CJ9
PDLALKDIACSEALL	ABCA4	196	P78363
ECVLRLNKQPDIALL	ALS2	1506	Q96Q42
DQCKLAAKELPLRNL	FAM106A	131	Q4KMX7
AAKELPLRNLLECRF	FAM106A	136	Q4KMX7
FLIRDILADCKPLAA	BARHL1	96	Q9BZE3
LKHCANFPRALEVLL	ASB16	356	Q96NS5
AKPSVLALCLLNLEV	CCNG2	201	Q16589
LTIGKRLAQCLHPAL	DOP1A	61	Q5JWR5
LLARPIGLAAQCLEA	CCDC142	166	Q17RM4
CSLLLQHSPALKAIR	ANKRD39	146	Q53RE8
ANRATKCAEALAPLL	ANKRD52	116	Q8NB46
LNLVAPDQLDLLEKC	CFLAR	141	O15519
IKPSRVVAILAAACL	GMCL1	176	Q96IK5
PCLLNFNILLEDKLT	PCDHGA2	101	Q9Y5H1
RVLAELPQCLRKEAA	RAB34	11	Q9BZG1
ALKRLLCLLPDNELD	LTN1	231	O94822
INSILELFPKLLCLD	NXF3	296	Q9H4D5
DQCKLAAKELPLRNL	FAM106C	131	P0CH98
AAKELPLRNLLECRF	FAM106C	136	P0CH98
AELPLIRLDFSCNKI	LRCH3	216	Q96II8
LEVAAAPLRLIAAKN	MDN1	6	Q9NU22
LLNPNLLAGIHCAKR	LYZL6	101	O75951
DTAACSLIQARLPLL	INTS1	1751	Q8N201
KANLPLLQRELLHCA	RUNX1T1	186	Q06455
LDCRHNLLKQLPDAI	LRRIQ4	426	A6NIV6
LPDAICQAQALKELR	LRRIQ4	436	A6NIV6
LCALDPNKISALREF	BEND2	716	Q8NDZ0
AAAARLLKPELQVCV	NANOS1	201	Q8WY41
CAHRLAPVDNINKLL	PLXNA3	86	P51805
CPLAERNQSRLKAEL	L3MBTL1	646	Q9Y468
ALRRCLELKPDNQTA	PEX5	391	P50542
KDSLADRALLPHVLC	HNRNPUL2	391	Q1KMD3
LDLADRLISKACPFA	MARCHF5	86	Q9NX47
AATRCQLKGPALLVL	DOK3	226	Q7L591
ALECKTLLPNEIAIR	KNL1	1161	Q8NG31
LLCLAVAALVRADAP	P4HB	6	P07237
LVCKLLLDLAENRPV	PTPDC1	291	A2A3K4
LKANLPLLQRELLHC	CBFA2T3	236	O75081
EESRLLQLLNKALPC	PLCXD1	61	Q9NUJ7
LLLPANEISKLLCSD	KLHL4	321	Q9C0H6
PACALALNEAKRLLV	CCDC105	291	Q8IYK2
ELQRVALALCLGKPA	ABCE1	466	P61221
KILDLLIPLTNRACD	ASB3	261	Q9Y575
PAKLRVLDLSCNRLN	CD14	296	P08571
TPFLDRCAERLNNLK	HEATR5B	481	Q9P2D3
ALQELPLCLRLNVAA	AVEN	186	Q9NQS1
LLARKDLPFRIQSCA	FRMPD3	841	Q5JV73
PQLLLLLLAAECALA	GAS6	16	Q14393
LCRLATPLAKNLEPV	EFNB1	21	P98172
CRLLSPLLKAFAQAA	GPAT2	691	Q6NUI2
NLLLDPDTAVLKLCD	GSK3B	186	P49841
LKCDISLLPERAILQ	FBXL13	151	Q8NEE6
PRTKALVLELLAAVC	FMNL1	266	O95466
RSALLKLACDLNHAP	ERAP2	751	Q6P179
ELVFRNLSKILPALC	DNAAF5	351	Q86Y56
LALCTPLSRLKQEVA	ICA1L	121	Q8NDH6
KAASLDCEDLLLPIA	DHX40	501	Q8IX18
VVRNACDLFIPLDKL	PEX11B	211	O96011
AALRACPPLRKALAV	SAC3D1	251	A6NKF1
AILPNILICLASRAK	SLFN13	876	Q68D06
PELLRICSLILADNK	IPO4	1021	Q8TEX9
FITLPDLNKLCAVRI	C18orf63	11	Q68DL7
PKAVREQLLALSACA	IRF2BP1	226	Q8IU81
AICARAIPASNRLLL	ERCC6L	241	Q2NKX8
PACFADLSRLRKLNL	LRRC30	156	A6NM36
LPVAVFSLQKLRCLD	LRRC8D	721	Q7L1W4
LLQCLPRNKVDATLR	PIDD1	631	Q9HB75
ILAFLRRVKACNPLD	PTPRF	1526	P10586
LVDGLKVCLQAALRA	PIWIL1	671	Q96J94
LVALACLLLSRPALQ	FREM3	16	P0C091
NATACAVPRLLIALL	SARS2	451	Q9NP81
LLRNDLCALECGIPK	SIDT2	531	Q8NBJ9
RQLPILAVKCTLADI	TDRD6	591	O60522
ALLCAPVRDEAIQKL	TCP11X1	166	B4DZS4
ALLCAPVRDEAIQKL	TCP11X2	71	Q5H9J9
VLPEDLQLKNARLLC	FANCL	41	Q9NW38
LVRDNADLRCELPKL	KIF5C	851	O60282
CLLEAALAAEVKKPA	SERPINH1	11	P50454
FLQKARALLDLCAAP	FTSJ3	41	Q8IY81
IAVLELAKSCPRVIN	STK17B	81	O94768
LATCFNALLPAVREK	SLC39A3	56	Q9BRY0
AILPNVLICLASRAK	SLFN11	876	Q7Z7L1
NALKFCNLALLLPTV	RMDN2	376	Q96LZ7
KNLPLDVAIECLTLR	TEKT2	106	Q9UIF3
PPDLLDRQKCLNALA	STRBP	186	Q96SI9
AFLCHLDNLLRPLLK	NHEJ1	71	Q9H9Q4
RDRLPLLDIACNKFL	PHYHIP	251	Q92561
EARDPSLLINACLNK	WDR13	366	Q9H1Z4
DAKLLVILCISPSQR	KIF25	331	Q9UIL4
DPLALCLLLQAYDKL	URB1	826	O60287
QLCREPQLAAKKAAL	STRC	1431	Q7RTU9
VAQLPLKACLLEDFL	SLC6A18	361	Q96N87
QLTCVLPILDNLLKA	BIRC2	471	Q13490
HVPLALCVLRKDINA	ACSS3	596	Q9H6R3
LALPQDLQAARALCV	CLDN6	71	P56747
LALPQDLQAARALCV	CLDN9	71	O95484
AAICLRNALLLLPEE	CNOT10	461	Q9H9A5
IALNDLCLVLRKSEP	RNF17	546	Q9BXT8
SAEPAEALVLACKRL	SLC7A6OS	16	Q96CW6
ELLARVFLALCDNPK	UNC45B	651	Q8IWX7
ALLAKLLCDQVVGAP	MPV17L	81	Q2QL34
FAIRLLKILCQDNPS	SERPINB9	11	P50453
ACPNIRKVDLSKNLL	TBCE	151	Q15813
NELEKLPSLRALSCL	TBCE	326	Q15813
ALLKLICDVARDPNL	TTI2	431	Q6NXR4
LCNRAELTPELLKIL	ROPN1	61	Q9HAT0
CFARQELALKARIPA	TMEM102	366	Q8N9M5
KALLLVPASVNCLRL	NUP188	1141	Q5SRE5
ASRPREALLQLQKLC	SCAND2P	56	Q9GZW5
ILCLARALLGPALKD	RFC2	86	P35250
AVKRLQLAVFAPALC	UNC5B	691	Q8IZJ1
EPIVNRGLAAALLLC	SART1	631	O43290
RKLLPADALVNCDLL	TBC1D4	1266	O60343
ALLVPAEALLLADVC	ZACN	236	Q401N2
LLLNANKINCIRPDA	SLIT1	386	O75093
DTILLNCLEAFKRIP	ZFYVE26	2441	Q68DK2
LKCARLFPDSNLEAV	TRPV4	351	Q9HBA0
LSPANQRKCERVLLA	TRIM28	696	Q13263
LPRELLCKLHVNRAA	ZC3H7B	76	Q9UGR2
DLNAALDNLRKVVPC	NEUROD2	136	Q15784