Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	procollagen galactosyltransferase activity	CERCAM COLGALT1	1.49e-05	4	32	2	GO:0050211
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK1 GRIK2	3.72e-05	6	32	2	GO:0015277
GeneOntologyMolecularFunction	extracellularly glutamate-gated ion channel activity	GRIK1 GRIK2	5.20e-05	7	32	2	GO:0005234
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK1 GRIK2	3.33e-04	17	32	2	GO:0004970
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK1 GRIK2	3.75e-04	18	32	2	GO:0015280
GeneOntologyMolecularFunction	scaffold protein binding	GRIK1 GRIK2 PLCG2	4.40e-04	93	32	3	GO:0097110
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK1 GRIK2	6.72e-04	24	32	2	GO:0099507
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK1 GRIK2	8.52e-04	27	32	2	GO:0008066
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	CERCAM COLGALT1	1.20e-03	32	32	2	GO:0035250
GeneOntologyMolecularFunction	SNARE binding	GRIK1 GRIK2 STXBP5	1.33e-03	136	32	3	GO:0000149
GeneOntologyMolecularFunction	galactosyltransferase activity	CERCAM COLGALT1	1.43e-03	35	32	2	GO:0008378
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	2.16e-03	43	32	2	GO:0005231
GeneOntologyMolecularFunction	sodium channel activity	GRIK1 GRIK2	3.14e-03	52	32	2	GO:0005272
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO5 GRIK1 GRIK2	3.59e-03	193	32	3	GO:0015276
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	3.76e-03	57	32	2	GO:1904315
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO5 GRIK1 GRIK2	3.80e-03	197	32	3	GO:0022834
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	4.16e-03	60	32	2	GO:0099529
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	ABCC4 GRIK1 GRIK2	4.36e-03	207	32	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	ABCC4 GRIK1 GRIK2	4.42e-03	208	32	3	GO:0005342
GeneOntologyMolecularFunction	hexosyltransferase activity	CERCAM POFUT1 COLGALT1	4.60e-03	211	32	3	GO:0016758
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIK1 GRIK2	4.86e-03	65	32	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIK1 GRIK2	4.86e-03	65	32	2	GO:0022824
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK1 GRIK2	6.42e-03	75	32	2	GO:0098960
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ANO5 ABCC4 GRIK1 GRIK2 NDUFB8	6.69e-03	758	32	5	GO:0015318
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	6.75e-03	77	32	2	GO:0005230
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK1 GRIK2	3.39e-05	6	32	2	GO:0032983
MousePheno	increased bone ossification	ANO5 IDS NOTCH2	2.73e-05	32	26	3	MP:0020039
Domain	Glyco_trans_25	CERCAM COLGALT1	8.52e-06	3	32	2	IPR002654
Domain	Glyco_transf_25	CERCAM COLGALT1	8.52e-06	3	32	2	PF01755
Domain	Iontro_rcpt	GRIK1 GRIK2	4.28e-04	18	32	2	IPR001320
Domain	Lig_chan	GRIK1 GRIK2	4.28e-04	18	32	2	PF00060
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.28e-04	18	32	2	PF10613
Domain	PBPe	GRIK1 GRIK2	4.28e-04	18	32	2	SM00079
Domain	Iono_rcpt_met	GRIK1 GRIK2	4.28e-04	18	32	2	IPR001508
Domain	Glu/Gly-bd	GRIK1 GRIK2	4.28e-04	18	32	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.28e-04	18	32	2	SM00918
Domain	ANF_receptor	GRIK1 GRIK2	1.82e-03	37	32	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIK1 GRIK2	1.82e-03	37	32	2	IPR001828
Domain	Peripla_BP_I	GRIK1 GRIK2	2.03e-03	39	32	2	IPR028082
Domain	F-box-like	FBXO11 FBH1	2.57e-03	44	32	2	PF12937
Domain	ER_TARGET	CERCAM COLGALT1	2.93e-03	47	32	2	PS00014
Domain	FBOX	FBXO11 FBH1	3.57e-03	52	32	2	SM00256
Domain	F-box	FBXO11 FBH1	5.87e-03	67	32	2	PF00646
Domain	FBOX	FBXO11 FBH1	6.75e-03	72	32	2	PS50181
Domain	F-box_dom	FBXO11 FBH1	7.30e-03	75	32	2	IPR001810
Domain	Nucleotide-diphossugar_trans	CERCAM COLGALT1	9.93e-03	88	32	2	IPR029044
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	POFUT1 NOTCH2	3.80e-05	6	23	2	M27068
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.14e-04	10	23	2	M10272
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.66e-04	12	23	2	MM15142
Pubmed	Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.	GRIK1 GRIK2	8.20e-07	2	32	2	12947409
Pubmed	Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.	GRIK1 GRIK2	8.20e-07	2	32	2	15537878
Pubmed	Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.	GRIK1 GRIK2	8.20e-07	2	32	2	15673679
Pubmed	Subunit composition of kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.20e-07	2	32	2	11144357
Pubmed	Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.	GRIK1 GRIK2	8.20e-07	2	32	2	25043179
Pubmed	Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.	GRIK1 GRIK2	8.20e-07	2	32	2	11182092
Pubmed	Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.	GRIK1 GRIK2	8.20e-07	2	32	2	15928066
Pubmed	Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.	GRIK1 GRIK2	8.20e-07	2	32	2	15358807
Pubmed	Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.	GRIK1 GRIK2	8.20e-07	2	32	2	14724198
Pubmed	Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.	GRIK1 GRIK2	8.20e-07	2	32	2	8700852
Pubmed	The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.	GRIK1 GRIK2	8.20e-07	2	32	2	15539395
Pubmed	Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.	GRIK1 GRIK2	8.20e-07	2	32	2	24760837
Pubmed	A mosaic of functional kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.20e-07	2	32	2	15483117
Pubmed	Functional characterization of kainate receptors in the mouse nucleus accumbens.	GRIK1 GRIK2	8.20e-07	2	32	2	11985817
Pubmed	RNA editing of human kainate receptor subunits.	GRIK1 GRIK2	8.20e-07	2	32	2	7696618
Pubmed	Q/R site editing controls kainate receptor inhibition by membrane fatty acids.	GRIK1 GRIK2	8.20e-07	2	32	2	16221857
Pubmed	Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.	GRIK1 GRIK2	8.20e-07	2	32	2	16219388
Pubmed	Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.	GRIK1 GRIK2	8.20e-07	2	32	2	8260617
Pubmed	Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.	GRIK1 GRIK2	8.20e-07	2	32	2	15014126
Pubmed	Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.	GRIK1 GRIK2	8.20e-07	2	32	2	11069933
Pubmed	The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.	GRIK1 GRIK2	2.46e-06	3	32	2	31513786
Pubmed	Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.	GRIK1 GRIK2	2.46e-06	3	32	2	15509753
Pubmed	Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines.	CTCF NOTCH2	2.46e-06	3	32	2	26983574
Pubmed	Differential trafficking of GluR7 kainate receptor subunit splice variants.	GRIK1 GRIK2	2.46e-06	3	32	2	15805114
Pubmed	Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.	GRIK1 GRIK2	2.46e-06	3	32	2	27346345
Pubmed	Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.	GRIK1 GRIK2	2.46e-06	3	32	2	1379666
Pubmed	QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.	QPCT CTCF	2.46e-06	3	32	2	34036385
Pubmed	Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.	GRIK1 GRIK2	2.46e-06	3	32	2	8730589
Pubmed	RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.	GRIK1 GRIK2	2.46e-06	3	32	2	7523595
Pubmed	Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.	GRIK1 GRIK2	2.46e-06	3	32	2	9880586
Pubmed	Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.	GRIK1 GRIK2	4.92e-06	4	32	2	17650106
Pubmed	The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.	GRIK1 GRIK2	4.92e-06	4	32	2	26277340
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK1 GRIK2	4.92e-06	4	32	2	15513934
Pubmed	Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	20081851
Pubmed	Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.	GRIK1 GRIK2	4.92e-06	4	32	2	30241548
Pubmed	Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	16354929
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	19369569
Pubmed	Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.	GRIK1 GRIK2	4.92e-06	4	32	2	25556835
Pubmed	Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.	GRIK1 GRIK2	4.92e-06	4	32	2	17174564
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK1 GRIK2	8.19e-06	5	32	2	23076118
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK1 GRIK2	8.19e-06	5	32	2	18793656
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK1 GRIK2	8.19e-06	5	32	2	28228252
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK1 GRIK2	8.19e-06	5	32	2	12223554
Pubmed	RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.	GRIK1 GRIK2	8.19e-06	5	32	2	1717158
Pubmed	Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.	GRIK1 GRIK2	8.19e-06	5	32	2	28854365
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK1 GRIK2	8.19e-06	5	32	2	18358623
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK1 GRIK2	8.19e-06	5	32	2	9593973
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK1 GRIK2	8.19e-06	5	32	2	29058671
Pubmed	Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.	GRIK1 GRIK2	1.23e-05	6	32	2	12597860
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK1 GRIK2	1.23e-05	6	32	2	28714086
Pubmed	Neto1 is an auxiliary subunit of native synaptic kainate receptors.	GRIK1 GRIK2	1.23e-05	6	32	2	21734292
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK1 GRIK2	1.72e-05	7	32	2	17428973
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIK1 GRIK2	1.72e-05	7	32	2	9016303
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK1 GRIK2	1.72e-05	7	32	2	19342380
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIK1 GRIK2	1.72e-05	7	32	2	9651535
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIK1 GRIK2	1.72e-05	7	32	2	1310861
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	RBM6 STXBP5 NOTCH2 KHSRP	2.23e-05	180	32	4	35198878
Pubmed	Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.	HSD3B2 NOTCH2	2.29e-05	8	32	2	23467742
Pubmed	Transmembrane topology of the glutamate receptor subunit GluR6.	GRIK1 GRIK2	2.29e-05	8	32	2	8163463
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK1 GRIK2	2.94e-05	9	32	2	34100982
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK1 GRIK2	2.94e-05	9	32	2	9051806
Pubmed	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.	ABCC4 GRIK1	4.49e-05	11	32	2	17903305
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRIK1 GRIK2	5.38e-05	12	32	2	11891216
Pubmed	A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.	POFUT1 NOTCH2	6.36e-05	13	32	2	32929274
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIK1 GRIK2	6.36e-05	13	32	2	20859245
Pubmed	Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.	POFUT1 NOTCH2	6.36e-05	13	32	2	18708576
Pubmed	FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.	FBXO11 FBH1	7.41e-05	14	32	2	23319600
Pubmed	Mapping lineage progression of somatic progenitor cells in the mouse fetal testis.	HSD3B2 NOTCH2	8.55e-05	15	32	2	27621062
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CERCAM ABCC4 GRIK2 POFUT1 COLGALT1 NOTCH2 KHSRP	9.08e-05	1201	32	7	35696571
Pubmed	A perivascular niche for multipotent progenitors in the fetal testis.	HSD3B2 NOTCH2	1.11e-04	17	32	2	30375389
Pubmed	Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity.	POFUT1 NOTCH2	1.24e-04	18	32	2	27364009
Pubmed	Neurogenin 2 has an essential role in development of the dentate gyrus.	GRIK2 NEUROG2	1.39e-04	19	32	2	18448566
Pubmed	Notch signaling maintains Leydig progenitor cells in the mouse testis.	HSD3B2 NOTCH2	1.70e-04	21	32	2	18927153
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	CERCAM COLGALT1	1.70e-04	21	32	2	23097496
Pubmed	Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development.	HSD3B2 NOTCH2	2.05e-04	23	32	2	28036337
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIK1 GRIK2	2.05e-04	23	32	2	8464923
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK1 GRIK2	2.24e-04	24	32	2	35746896
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GRIK1 GRIK2	2.24e-04	24	32	2	22534482
Pubmed	Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.	NEUROG2 NOTCH2	2.43e-04	25	32	2	35815610
Pubmed	Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain.	NEUROG2 NOTCH2	2.63e-04	26	32	2	26912775
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	POFUT1 NOTCH2	2.84e-04	27	32	2	21791528
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	RBM6 OTUD4 COL5A3 ABCC4	3.88e-04	378	32	4	34315543
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	CERCAM POFUT1 COLGALT1	4.62e-04	164	32	3	32409323
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	RBM6 CEP68 GRIK2	5.22e-04	171	32	3	36629882
Pubmed	Regulation of Neurogenesis in Mouse Brain by HMGB1.	NEUROG2 NOTCH2	5.35e-04	37	32	2	32708917
Pubmed	Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.	HSD3B2 NOTCH2	5.35e-04	37	32	2	26697723
Pubmed	MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.	NEUROG2 NOTCH2	5.95e-04	39	32	2	36064547
Pubmed	MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.	OTUD4 FBXO11	6.58e-04	41	32	2	34964862
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	POFUT1 NOTCH2	6.58e-04	41	32	2	22675208
Pubmed	A family of mammalian F-box proteins.	FBXO11 FBH1	6.90e-04	42	32	2	10531037
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	OTUD4 CTCF	7.57e-04	44	32	2	27505670
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	FBXO11 FBH1	9.01e-04	48	32	2	33504946
Cytoband	Ensembl 112 genes in cytogenetic band chr1p12	HSD3B2 NOTCH2	6.34e-04	53	32	2	chr1p12
Cytoband	4q25	TIFA NEUROG2	1.01e-03	67	32	2	4q25
Cytoband	Ensembl 112 genes in cytogenetic band chr4q25	TIFA NEUROG2	1.85e-03	91	32	2	chr4q25
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK1 GRIK2	1.41e-05	5	22	2	1199
GeneFamily	Cyclins\|F-boxes other	FBXO11 FBH1	1.02e-03	39	22	2	560
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Mesoderm\|10w / Sample Type, Dataset, Time_group, and Cell type.	QPCT COL5A3 ABCC4 ZNF296	1.24e-05	200	32	4	9ef226ebb0a7cdb9431e2fa65faa2a7d67da590d
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.20e-04	134	32	3	3dd4b5eddc94c1d49ab23b287ee234db3a55331b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	QPCT GRIK2 PLCG2	1.26e-04	136	32	3	9cf076597e6fd9390850fda259daa13022f15893
ToppCell	ASK454-Epithelial-Type_2\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	ANO5 POFUT1 TRIM16L	1.26e-04	136	32	3	ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.28e-04	137	32	3	b03f19b233c1c809f2cd2b4a7642eeaf254a6289
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.28e-04	137	32	3	ca8fdbe66a854e6283b22179ec9359ea9e86cd8e
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.34e-04	139	32	3	789edd3c98e7c5c1cc402c780fded9a9dfd1dfb8
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.68e-04	150	32	3	b30f52b94ce772632a1f2f5e0837db876cf92651
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RHOG CERCAM TEX52	1.68e-04	150	32	3	05b9a9cbc5a95cdaf45d5f173e132acd4da9aa8a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFA GRIK2 HSD3B2	2.03e-04	160	32	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TIFA ABCC4 PLCG2	2.03e-04	160	32	3	741e3b3f4ec5c77752da54746451f332435226e3
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFA GRIK2 HSD3B2	2.03e-04	160	32	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ILDR1 PLCG2 STXBP5	2.10e-04	162	32	3	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	QPCT GRIK2 PLCG2	2.14e-04	163	32	3	ec9a20cfe0d69430f9c68cddd1ab0e4a3e4554b8
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOG GRIK2 PLCG2	2.43e-04	170	32	3	c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERCAM ABCC4 PLCG2	2.47e-04	171	32	3	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COLGALT1 STXBP5 LPO	2.51e-04	172	32	3	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ILDR1 ZNF296	2.55e-04	33	32	2	67918bf4ef5b8207b4c6a98484fcd027447b7c61
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ILDR1 ZNF296	2.55e-04	33	32	2	fdfcbdec8e553ca8bf4d97ba63e95ebbfa556faa
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	POFUT1 TRIM16L NOTCH2	2.55e-04	173	32	3	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCLAF3 CERCAM ZNF296	2.60e-04	174	32	3	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	QPCT CEP68 COLGALT1	2.69e-04	176	32	3	bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	ILDR1 ABCC4 NOTCH2	2.69e-04	176	32	3	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	CEP68 ABCC4 FBH1	2.69e-04	176	32	3	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TIFA RHOG POFUT1	2.69e-04	176	32	3	90f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	QPCT GRIK1 PLCG2	2.91e-04	181	32	3	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	QPCT GRIK1 GRIK2	3.01e-04	183	32	3	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	QPCT CERCAM POFUT1	3.11e-04	185	32	3	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	QPCT CERCAM COL5A3	3.26e-04	188	32	3	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CERCAM COL5A3 NOTCH2	3.36e-04	190	32	3	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANO5 COLGALT1 NDUFB8	3.41e-04	191	32	3	5c0c44612b4cdbf89c0f1f219416374a7541f610
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	QPCT CERCAM COL5A3	3.41e-04	191	32	3	9f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CERCAM COL5A3 NOTCH2	3.41e-04	191	32	3	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	QPCT CERCAM COL5A3	3.46e-04	192	32	3	321850b0f881420c2d57d3e825e365c82fa511ab
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	QPCT CERCAM COL5A3	3.46e-04	192	32	3	cf2765d8bc074f7f9ee864eae632a3b705175842
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM COL5A3	3.46e-04	192	32	3	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	facs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.52e-04	193	32	3	735a72fac16397edde95e8eefa6f83caeb5ee5df
ToppCell	facs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.52e-04	193	32	3	ff901d2f3d7a511639c1e3b76058896c0d8a8602
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM COL5A3	3.52e-04	193	32	3	160691b671710be10220803d788c2c961c236af1
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	QPCT CERCAM COL5A3	3.52e-04	193	32	3	051f61156b0e2e95292b2d8377faf3190b50f264
ToppCell	wk_20-22-Hematologic_Lymphocytic-B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TIFA PLCG2 ZNF296	3.57e-04	194	32	3	aca97fbf1a932df457a82709c2a2dc9081e018df
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BCLAF3 TIFA ANO5	3.57e-04	194	32	3	0e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCell	facs-SCAT-Fat-3m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM COL5A3	3.57e-04	194	32	3	14b614f039bc866a1348a2728a68b7d254c7748c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM COL5A3	3.57e-04	194	32	3	68c7bfead1158641928cc276f599b4a79e06c73c
ToppCell	distal-3-Hematologic-Plasma\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TIFA QPCT CERCAM	3.57e-04	194	32	3	d6e2e17732ad75604525fd65b2a3171e86cd01c7
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM COL5A3	3.57e-04	194	32	3	f6aeae6a1e4017e341323fd4784c9e3bae00552b
ToppCell	facs-Heart-LA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.62e-04	195	32	3	79a6e8e6de040ff07539e8901fc407363a50e355
ToppCell	distal-Hematologic-Plasma-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TIFA QPCT CERCAM	3.62e-04	195	32	3	4280a5bc5ed9bb12e278b182e0be6cb88fa83d83
ToppCell	facs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.68e-04	196	32	3	ad1838dabd043cb140260843e3527d8c7d58850e
ToppCell	distal-Hematologic-Plasma\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TIFA QPCT CERCAM	3.68e-04	196	32	3	2a11dc1e51c64af7705e1622a9da583a6634c563
ToppCell	facs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.68e-04	196	32	3	cbc15c0769016fe9972445169029bd8d14a7e6ef
ToppCell	proximal-Epithelial-Ionocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	QPCT GRIK1 PLCG2	3.73e-04	197	32	3	e5d5accefaacea5ed2e22f906f5bcbc75083f287
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|hematopoetic_progenitors / Lineage and Cell class	RHOG ABCC4 STXBP5	3.73e-04	197	32	3	6172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCell	proximal-Epithelial-Ionocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	QPCT GRIK1 PLCG2	3.73e-04	197	32	3	f65c35761da7c168d5c6e4d7edf5dafa26652fe4
ToppCell	proximal-3-Epithelial-Ionocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	QPCT GRIK1 PLCG2	3.73e-04	197	32	3	288492fc67d8e81349d38e82caf1f1890276b299
ToppCell	10x3'2.3-week_17-19\|World / cell types per 3 fetal stages;per 3',per 5'	TIFA PLCG2 ZNF296	3.73e-04	197	32	3	f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell	facs-Heart-LA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCT CERCAM NOTCH2	3.73e-04	197	32	3	2a91738cb6d7588869dd00deeea0cbbc2d6aa34d
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma\|TCGA-Bladder / Sample_Type by Project: Shred V9	CERCAM COL5A3 COLGALT1	3.79e-04	198	32	3	65875fbd99393cdd62595c713ab90db06d28081f
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-B-B_memory\|Multiple_Sclerosis / Disease, condition lineage and cell class	ILDR1 PLCG2 ZNF296	3.85e-04	199	32	3	ae2979c0d2711580863d3b751f6ff1e3abdfd90e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate\|10w / Sample Type, Dataset, Time_group, and Cell type.	CEP68 PLCG2 CTCF	3.90e-04	200	32	3	e5a8647c47a49c8c90c78d681193946de103d8ff
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-St18_(Lateral_CA3_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ANO5 HSD3B2	3.95e-04	41	32	2	083d2aab96ba9449797f955507c4a1be51ac5c8d
Drug	5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime	GRIK1 GRIK2	1.79e-06	2	31	2	ctd:C084273
Drug	Roxarsone [121-19-7]; Down 200; 15.2uM; PC3; HT_HG-U133A	FRS3 CEP68 FBXO11 IDS KHSRP	6.05e-06	194	31	5	5051_DN
Drug	Mimosine [500-44-7]; Down 200; 20.2uM; PC3; HT_HG-U133A	FRS3 CEP68 PLCG2 IDS NOTCH2	6.36e-06	196	31	5	6703_DN
Disease	venous thromboembolism, tissue plasminogen activator measurement	PLCG2 STXBP5	2.67e-04	23	31	2	EFO_0004286, EFO_0004791
Disease	lifestyle measurement, anxiety disorder measurement	RBM6 ILDR1 GRIK2	4.00e-04	137	31	3	EFO_0007795, EFO_0010724
Disease	factor VIII measurement, venous thromboembolism	PLCG2 STXBP5	5.87e-04	34	31	2	EFO_0004286, EFO_0004630
Disease	venous thromboembolism, von Willebrand factor measurement	PLCG2 STXBP5	8.96e-04	42	31	2	EFO_0004286, EFO_0004629
Disease	Diffuse Large B-Cell Lymphoma	FBXO11 NOTCH2	1.53e-03	55	31	2	C0079744
Disease	Chronic Lymphocytic Leukemia	QPCT PLCG2	1.53e-03	55	31	2	C0023434
Disease	urate measurement	RBM6 ILDR1 GRIK1 HSD3B2 NOTCH2	2.24e-03	895	31	5	EFO_0004531
Disease	Glioblastoma	GRIK2 NOTCH2	3.13e-03	79	31	2	C0017636
Disease	age of onset of asthma	RBM6 CTCF	3.13e-03	79	31	2	OBA_2001001
Disease	Giant Cell Glioblastoma	GRIK2 NOTCH2	3.53e-03	84	31	2	C0334588

Protein segments in the cluster

Peptide	Gene	Start	Entry
HEEEPLENTWPTPYP	HSD3B2	141	P26439
PLHDGQYWKPSEPPN	ANO5	251	Q75V66
QYWKPSEPPNPTNER	ANO5	256	Q75V66
QEDPSWQKDPDYQPP	CTCF	186	P49711
PDRHSPLWNPNKEYE	CEP68	286	Q76N32
PYEWYNPHPCNPDSD	GRIK1	601	P39086
PVYPHNPWFQEAPAA	OTUD4	741	Q01804
PSASAWPEEKNYHQP	QPCT	31	Q16769
EHPYLTPSPESPDQW	NOTCH2	2411	Q04721
SDMDYWQPPPPDKHR	NEUROG2	246	Q9H2A3
NYQPWGPEPELPLHT	LPO	481	P22079
SPHWPEEKPPSYRSL	ILDR1	501	Q86SU0
PNPNPHESKPWYYDS	PLCG2	636	P16885
PKLPDRSQHERDPWY	NDUFB8	76	O95169
EYQKRPPPAWPHEGV	ABCC4	1026	O15439
RWTNRDPNHGLYPKP	FBH1	31	Q8NFZ0
PKWKPEHSLPPYQED	BCLAF3	236	A2AJT9
INPEEYEHPNPWKES	FBXO11	221	Q86XK2
HYENLPPLPPVWESQ	FRS3	321	O43559
YPRPSDIPQWNSDKP	IDS	466	P22304
PYEWYNPHPCNPDSD	GRIK2	586	Q13002
EEPRSYPDEEGPKHW	COLGALT1	121	Q8NBJ5
EPRFYPDEEGPKHWT	CERCAM	101	Q5T4B2
HPHLPDGEYWIDPNQ	COL5A3	1551	P25940
AVPPWIEYQHHKPPF	POFUT1	66	Q9H488
YPQWQPPAPHDPSKA	KHSRP	551	Q92945
WNRDYPPPPLKSHAQ	RBM6	26	P78332
ENNWPPHRPIPEYGT	TIFA	151	Q96CG3
SPPSYENVRHKWHPE	RHOG	86	P84095
IPPAYEPWREHNVPE	STXBP5	871	Q5T5C0
RSWPCPNPLPHYQEK	TEX52	236	A6NCN8
PNYPDRQPWTDKHPD	ZNF296	96	Q8WUU4
NTTPWEHPYPDLPSR	TRIM16L	181	Q309B1