Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	LARS1 WARS2 YARS2 IARS2	6.93e-05	42	105	4	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	LARS1 WARS2 YARS2 IARS2	6.93e-05	42	105	4	GO:0004812
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ZGRF1 RSF1 LARS1 PNLDC1 METTL4 WARS2 YARS2 IARS2 POLI HFM1 POLK TRDMT1	1.47e-04	645	105	12	GO:0140640
GeneOntologyBiologicalProcess	skeletal muscle satellite cell migration	RHOA RHOC	2.33e-05	2	100	2	GO:1902766
GeneOntologyBiologicalProcess	tRNA aminoacylation for protein translation	LARS1 WARS2 YARS2 IARS2	5.05e-05	42	100	4	GO:0006418
GeneOntologyBiologicalProcess	tRNA aminoacylation	LARS1 WARS2 YARS2 IARS2	6.65e-05	45	100	4	GO:0043039
GeneOntologyBiologicalProcess	amino acid activation	LARS1 WARS2 YARS2 IARS2	7.26e-05	46	100	4	GO:0043038
GeneOntologyBiologicalProcess	cell junction assembly	SPTBN2 CLSTN2 CSMD2 ECT2 RHOA RHOC LGI2 LRP1 CDH5 CDH17 GNPAT	9.85e-05	569	100	11	GO:0034329
Domain	aa-tRNA-synth_I_CS	LARS1 WARS2 YARS2 IARS2	2.52e-06	18	103	4	IPR001412
Domain	AA_TRNA_LIGASE_I	LARS1 WARS2 YARS2 IARS2	3.17e-06	19	103	4	PS00178
Domain	Rossmann-like_a/b/a_fold	LARS1 WARS2 YARS2 IARS2	9.12e-05	43	103	4	IPR014729
Domain	-	LARS1 WARS2 YARS2 IARS2	9.12e-05	43	103	4	3.40.50.620
Domain	aa-tRNA-synth_Ic	WARS2 YARS2	1.79e-04	4	103	2	IPR002305
Domain	-	GTF2IRD2B GTF2IRD2	1.79e-04	4	103	2	3.90.1460.10
Domain	IMS	POLI POLK	1.79e-04	4	103	2	PF00817
Domain	IMS_C	POLI POLK	1.79e-04	4	103	2	PF11799
Domain	UMUC	POLI POLK	1.79e-04	4	103	2	PS50173
Domain	tRNA-synt_1b	WARS2 YARS2	1.79e-04	4	103	2	PF00579
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.79e-04	4	103	2	PS51139
Domain	-	POLI POLK	1.79e-04	4	103	2	3.30.1490.100
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.79e-04	4	103	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.79e-04	4	103	2	IPR004212
Domain	DNA_pol_Y-fam_little_finger	POLI POLK	1.79e-04	4	103	2	IPR017961
Domain	Val/Leu/Ile-tRNA-synth_edit	LARS1 IARS2	4.45e-04	6	103	2	IPR009008
Domain	Anticodon_1	LARS1 IARS2	4.45e-04	6	103	2	PF08264
Domain	M/V/L/I-tRNA-synth_anticd-bd	LARS1 IARS2	4.45e-04	6	103	2	IPR013155
Domain	-	LARS1 IARS2	4.45e-04	6	103	2	3.90.740.10
Domain	UmuC	POLI POLK	4.45e-04	6	103	2	IPR001126
Domain	aa-tRNA-synth_Ia	LARS1 IARS2	6.21e-04	7	103	2	IPR002300
Domain	tRNA-synt_1	LARS1 IARS2	6.21e-04	7	103	2	PF00133
Domain	-	LARS1 IARS2	1.60e-03	11	103	2	1.10.730.10
Domain	Dynein_heavy_chain_D4_dom	DNAH14 DNAH6	2.62e-03	14	103	2	IPR024317
Domain	Dynein_HC_stalk	DNAH14 DNAH6	2.62e-03	14	103	2	IPR024743
Domain	MT	DNAH14 DNAH6	2.62e-03	14	103	2	PF12777
Domain	AAA_8	DNAH14 DNAH6	2.62e-03	14	103	2	PF12780
Domain	DHC_fam	DNAH14 DNAH6	3.02e-03	15	103	2	IPR026983
Domain	Dynein_heavy	DNAH14 DNAH6	3.02e-03	15	103	2	PF03028
Domain	Dynein_heavy_dom	DNAH14 DNAH6	3.02e-03	15	103	2	IPR004273
Domain	tRNAsynth_Ia_anticodon-bd	LARS1 IARS2	3.02e-03	15	103	2	IPR009080
Domain	Glycoside_hydrolase_SF	LCT AGL OGA	3.12e-03	53	103	3	IPR017853
Domain	CADHERIN_1	PCDHA11 CLSTN2 CDH5 CDH17	3.55e-03	113	103	4	PS00232
Domain	Cadherin	PCDHA11 CLSTN2 CDH5 CDH17	3.55e-03	113	103	4	PF00028
Domain	CADHERIN_2	PCDHA11 CLSTN2 CDH5 CDH17	3.66e-03	114	103	4	PS50268
Domain	-	PCDHA11 CLSTN2 CDH5 CDH17	3.66e-03	114	103	4	2.60.40.60
Domain	CA	PCDHA11 CLSTN2 CDH5 CDH17	3.78e-03	115	103	4	SM00112
Domain	Cadherin-like	PCDHA11 CLSTN2 CDH5 CDH17	3.89e-03	116	103	4	IPR015919
Domain	Cadherin	PCDHA11 CLSTN2 CDH5 CDH17	4.14e-03	118	103	4	IPR002126
Domain	RHO	RHOA RHOC	5.36e-03	20	103	2	PS51420
Pathway	KEGG_AMINOACYL_TRNA_BIOSYNTHESIS	LARS1 WARS2 YARS2 IARS2	5.49e-05	41	72	4	M14691
Pathway	REACTOME_TRNA_AMINOACYLATION	LARS1 WARS2 YARS2 IARS2	6.05e-05	42	72	4	M456
Pathway	SA_TRKA_RECEPTOR	AKT3 RHOA NGF	8.25e-05	17	72	3	M18895
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	EXOC6 RSF1 MRPL10 NEB CSMD2 RHOA RAD51AP2 KMT2D HFM1 IL17RD CDH17	3.81e-06	638	105	11	31182584
Pubmed	KLF10 transcription factor regulates hepatic glucose metabolism in mice.	LEPR KLF10	9.03e-06	2	105	2	28836014
Pubmed	RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.	RHOA RHOC	9.03e-06	2	105	2	21454503
Pubmed	Activation of a bacterial virulence protein by the GTPase RhoA.	RHOA RHOC	9.03e-06	2	105	2	19887681
Pubmed	The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells.	POLI POLK	9.03e-06	2	105	2	21454642
Pubmed	Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.	RHOA RHOC	9.03e-06	2	105	2	12808121
Pubmed	Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers.	RHOA RHOC	9.03e-06	2	105	2	20503409
Pubmed	Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.	RHOA RHOC	9.03e-06	2	105	2	7989340
Pubmed	Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.	RHOA RHOC	9.03e-06	2	105	2	33825439
Pubmed	Dengue virus or NS1 protein induces trans-endothelial cell permeability associated with VE-Cadherin and RhoA phosphorylation in HMEC-1 cells preventable by Angiopoietin-1.	RHOA CDH5	9.03e-06	2	105	2	30355397
Pubmed	Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo.	RHOA RHOC	9.03e-06	2	105	2	20828398
Pubmed	Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.	RHOA RHOC	9.03e-06	2	105	2	15668138
Pubmed	Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma.	RHOA RHOC	9.03e-06	2	105	2	17896152
Pubmed	Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.	RHOA RHOC	9.03e-06	2	105	2	7835413
Pubmed	Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice.	POLI POLK	9.03e-06	2	105	2	15860226
Pubmed	Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases iota and kappa.	POLI POLK	9.03e-06	2	105	2	16354708
Pubmed	Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1.	MPP3 MMP1	9.03e-06	2	105	2	24513266
Pubmed	ABCs of RhoGTPases indicating potential role as oncotargets.	RHOA RHOC	9.03e-06	2	105	2	28508825
Pubmed	Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters.	RHOA RHOC	9.03e-06	2	105	2	19499974
Pubmed	Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.	ECT2 RHOA	9.03e-06	2	105	2	16352658
Pubmed	Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.	RHOA RHOC	9.03e-06	2	105	2	21208644
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	9.03e-06	2	105	2	15388857
Pubmed	Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity.	RHOA RHOC	9.03e-06	2	105	2	19642867
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	LARS1 SEC22B LDHA YARS2 RHOA IARS2 TPP1 ASPH LRP1 NOS2 HSPA4 GNPAT	1.14e-05	859	105	12	31536960
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZGRF1 ECT2 LEPR EFNA1 DUSP16 TBCK POLK NOS2	1.51e-05	363	105	8	14691545
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	EXOC6 HIGD2A MRPL10 KIAA1671 CEP170 RHOA RHOC IARS2 AGL PANK4	1.57e-05	606	105	10	36538041
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FLNC NEB ECT2 CEP170 GSDME KLF10 AGL SKAP2 WIPF2	2.06e-05	497	105	9	23414517
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SPTBN2 RSF1 LARS1 DNAH14 YARS2 RHOC GTF2IRD2B GSDME TPP1 AGL POLI POLK	2.36e-05	925	105	12	28986522
Pubmed	Upstream stimulatory factors are involved in the P1 promoter directed transcription of the A beta H-J-J locus.	ASPH USF1	2.70e-05	3	105	2	19087304
Pubmed	Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.	LEPR PTPRC	2.70e-05	3	105	2	30612898
Pubmed	RhoA, RhoB and RhoC have different roles in cancer cell migration.	RHOA RHOC	2.70e-05	3	105	2	23488932
Pubmed	A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.	RHOA RHOC	2.70e-05	3	105	2	12939257
Pubmed	Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.	RHOA RHOC	2.70e-05	3	105	2	17018591
Pubmed	Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.	POLI POLK	2.70e-05	3	105	2	28939775
Pubmed	RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).	RHOA RHOC	2.70e-05	3	105	2	24096540
Pubmed	Structural and mechanistic insights into the interaction between Rho and mammalian Dia.	RHOA RHOC	2.70e-05	3	105	2	15864301
Pubmed	Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.	ECT2 RHOA	2.70e-05	3	105	2	16394104
Pubmed	Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.	RHOA RHOC	2.70e-05	3	105	2	29500478
Pubmed	RhoA, RhoB and RhoC differentially regulate endothelial barrier function.	RHOA RHOC	2.70e-05	3	105	2	28949796
Pubmed	Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells.	LEPR PTPRC	2.70e-05	3	105	2	34497346
Pubmed	Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway.	LEPR RHOA	2.70e-05	3	105	2	16996478
Pubmed	Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.	LEPR LRP1	2.70e-05	3	105	2	21264353
Pubmed	USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells.	USF1 NOS2	2.70e-05	3	105	2	12225970
Pubmed	A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.	RHOA RHOC	2.70e-05	3	105	2	21087931
Pubmed	RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.	RHOA RHOC	2.70e-05	3	105	2	20697357
Pubmed	PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.	DUSP16 MMP1	2.70e-05	3	105	2	23639976
Pubmed	Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases.	RHOA RHOC	2.70e-05	3	105	2	24447566
Pubmed	NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion molecule.	RHOA NGF	2.70e-05	3	105	2	12056835
Pubmed	Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells.	RHOA RHOC	2.70e-05	3	105	2	19477269
Pubmed	RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.	RHOA RHOC	2.70e-05	3	105	2	21757538
Pubmed	p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity.	RHOA NGF	2.70e-05	3	105	2	15128850
Pubmed	Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.	POLI POLK	2.70e-05	3	105	2	15199127
Pubmed	Persistently active microbial molecules prolong innate immune tolerance in vivo.	AOAH PTPRC	2.70e-05	3	105	2	23675296
Pubmed	High-Affinity Binding of LDL Receptor-Related Protein 1 to Matrix Metalloprotease 1 Requires Protease:Inhibitor Complex Formation.	LRP1 MMP1	2.70e-05	3	105	2	32702237
Pubmed	RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.	RHOA RHOC	2.70e-05	3	105	2	28536953
Pubmed	Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models.	LEPR CDH5	2.70e-05	3	105	2	38123537
Pubmed	Divergence of Rho residue 43 impacts GEF activity.	RHOA RHOC	2.70e-05	3	105	2	22673745
Pubmed	The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells.	RHOA RHOC	2.70e-05	3	105	2	26741994
Pubmed	Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA.	ECT2 RHOA	2.70e-05	3	105	2	36416720
Pubmed	Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.	RHOA RHOC	2.70e-05	3	105	2	19421144
Pubmed	Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure.	STAT5A PTPRC	2.70e-05	3	105	2	38091951
Pubmed	Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.	RHOA RHOC	2.70e-05	3	105	2	15642170
Pubmed	Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells.	RHOA RHOC	2.70e-05	3	105	2	27147504
Pubmed	SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.	RHOA RHOC	2.70e-05	3	105	2	21242305
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.70e-05	3	105	2	15100712
Pubmed	Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.	RHOA RHOC	2.70e-05	3	105	2	31324164
Pubmed	Genetic and Immune Dysregulation in Chronic Rhinosinusitis.	AOAH NOS2	2.70e-05	3	105	2	27888910
Pubmed	The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.	RHOA RHOC	2.70e-05	3	105	2	8816443
Pubmed	RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.	RHOA RHOC	2.70e-05	3	105	2	32719397
Pubmed	Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury.	RHOA RHOC	2.70e-05	3	105	2	34759029
Pubmed	Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.	DNAH14 DNAH6	2.70e-05	3	105	2	29323929
Pubmed	A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair.	POLI POLK	2.70e-05	3	105	2	14630940
Pubmed	A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.	NDNF ZGRF1 TBCK ENPEP	4.34e-05	64	105	4	20332099
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNC SPTBN2 LARS1 LDHA CEP170 RHOA TPP1 AGL NUFIP2 PANK4 OGA HSPA4 NUP153	4.38e-05	1149	105	13	35446349
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	FLNC KRT16 LARS1 SEC22B LDHA IARS2 ASPH	4.69e-05	312	105	7	37120454
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	SLC2A9 LEPR AGL HFM1 FGL1 IL17RD TRDMT1	4.79e-05	313	105	7	20800603
Pubmed	Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3.	LEPR RHOA	5.40e-05	4	105	2	27649495
Pubmed	NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.	PTPRC NOS2	5.40e-05	4	105	2	24143212
Pubmed	Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.	ECT2 RHOA	5.40e-05	4	105	2	16118207
Pubmed	The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.	RHOA RHOC	5.40e-05	4	105	2	20974804
Pubmed	Evolution of general transcription factors.	GTF2IRD2B GTF2IRD2	5.40e-05	4	105	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2B GTF2IRD2	5.40e-05	4	105	2	22899722
Pubmed	The armadillo protein p0071 regulates Rho signalling during cytokinesis.	ECT2 RHOA	5.40e-05	4	105	2	17115030
Pubmed	Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo.	PTPRC CDH5	5.40e-05	4	105	2	24757004
Pubmed	Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis.	RHOA RHOC	5.40e-05	4	105	2	26615410
Pubmed	Rho and anillin-dependent control of mDia2 localization and function in cytokinesis.	ECT2 RHOA	5.40e-05	4	105	2	20660154
Pubmed	Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa.	POLI POLK	5.40e-05	4	105	2	12509270
Pubmed	Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.	RHOA RHOC	5.40e-05	4	105	2	10559899
Pubmed	XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.	RHOA RHOC	5.40e-05	4	105	2	12221096
Pubmed	Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.	RHOA RHOC	5.40e-05	4	105	2	27269051
Pubmed	Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.	ECT2 RHOA	5.40e-05	4	105	2	16247472
Pubmed	RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.	RHOA RHOC	5.40e-05	4	105	2	21576392
Pubmed	Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice.	LEPR STAT5A	5.40e-05	4	105	2	23696567
Pubmed	Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.	RHOA RHOC	5.40e-05	4	105	2	26030593
Pubmed	Eight independent Ldh-1 mutations of the mouse recovered in mutagenicity experiments: biochemical characteristics and chromosomal localization.	LDHA PTPRC	5.40e-05	4	105	2	2744450
Pubmed	Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway.	RHOA RHOC	5.40e-05	4	105	2	20460433
Pubmed	O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.	LEPR OGA	5.40e-05	4	105	2	21471514
Pubmed	Inflammation-induced nitric oxide suppresses PPARα expression and function via downregulation of Sp1 transcriptional activity in adipocytes.	LEPR NOS2	5.40e-05	4	105	2	37739218
Pubmed	Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.	LEPR NOS2	5.40e-05	4	105	2	21700708
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2B GTF2IRD2	5.40e-05	4	105	2	17823943
GeneFamily	Aminoacyl tRNA synthetases, Class I	LARS1 WARS2 YARS2 IARS2	5.66e-07	19	65	4	131
Coexpression	SENESE_HDAC3_TARGETS_UP	AKT3 LEPR CEP170 RHOC EFNA1 PCNX4 TPP1 DUSP16 ASPH MMP1 KDM1B HSPA4	6.46e-07	495	104	12	M8451
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PNLDC1 MED13L ECT2 WARS2 KIAA1671 USF1	2.84e-06	167	105	6	7e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GTF2IRD2B KMT2D AGL DUSP16 TBCK POLI	5.96e-06	190	105	6	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GTF2IRD2B KMT2D AGL DUSP16 TBCK POLI	6.33e-06	192	105	6	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|COVID-19_Convalescent / Disease condition and Cell class	RHOA PTPRC KLF10 TPP1 LRP1 SKAP2	7.55e-06	198	105	6	f65fd9b773aeafa55e38309479954a8e41371f52
Disease	ulcerative colitis (implicated_via_orthology)	RHOA RHOC MMP1	1.43e-06	7	103	3	DOID:8577 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AKT3 LEPR PPP1R3A AFF1 OGA	3.44e-05	105	103	5	DOID:9352 (implicated_via_orthology)
Disease	Sensorineural hearing loss, bilateral	GSDME OTOF	3.61e-05	3	103	2	C0452138
Disease	chronic venous insufficiency, Varicose veins	KCNH8 SKAP2	3.61e-05	3	103	2	EFO_0007940, HP_0002619
Disease	Malignant neoplasm of breast	ECT2 LEPR STAT5A PPP1R3A KMT2D EFNA1 PTPRC OTOF AFF1 MMP1 NOS2 CDH5 ENPEP	9.45e-05	1074	103	13	C0006142
Disease	monocyte count	AKT3 SPTBN2 MED13L LCT LEPR BBX PTPRC DUSP16 NUFIP2 HFM1 USF1 WIPF2 HSPA4 RPAP2	2.00e-04	1320	103	14	EFO_0005091
Disease	degenerative disc disease (implicated_via_orthology)	NGF MMP1	2.51e-04	7	103	2	DOID:90 (implicated_via_orthology)
Disease	peroxisomal biogenesis disorder (implicated_via_orthology)	RHOA RHOC	3.33e-04	8	103	2	DOID:0080377 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (is_implicated_in)	CASQ1 LEPR PPP1R3A USF1 NOS2	3.41e-04	171	103	5	DOID:9352 (is_implicated_in)
Disease	Liver Cirrhosis, Experimental	ECT2 SERPINA4 PTPRC AGL DUSP16 MMP1 SKAP2 NOS2 CDH5 ENPEP	3.82e-04	774	103	10	C0023893
Disease	infection	ZNF689 RSF1	4.28e-04	9	103	2	EFO_0000544
Disease	blood cobalt measurement	NDNF SLC2A9 AOAH CC2D2A	4.41e-04	101	103	4	EFO_0007577
Disease	triglycerides in very large VLDL measurement	EXOC6 AFF1 RFLNA	1.00e-03	56	103	3	EFO_0022325
Disease	triglycerides in VLDL measurement	EXOC6 AFF1 RFLNA	1.17e-03	59	103	3	EFO_0022326
Disease	phospholipids in VLDL measurement	MPP3 EXOC6 AFF1	1.17e-03	59	103	3	EFO_0022301
Disease	total lipids in VLDL measurement	MPP3 EXOC6 AFF1	1.22e-03	60	103	3	EFO_0022314
Disease	T-Cell Lymphoma	RHOA KMT2D	1.40e-03	16	103	2	C0079772
Disease	cholesterol in very large VLDL measurement	MPP3 EXOC6 AFF1	1.54e-03	65	103	3	EFO_0022230
Disease	Glycogen storage disease	LDHA AGL	1.59e-03	17	103	2	cv:C0017919
Disease	total lipids in large VLDL	MPP3 EXOC6 AFF1	1.68e-03	67	103	3	EFO_0022175
Disease	coronary artery disease (is_marker_for)	NGF NOS2 CDH5	1.68e-03	67	103	3	DOID:3393 (is_marker_for)
Disease	Alzheimer disease, educational attainment	CEP170 RHOA EFNA1 OGA IP6K2	1.77e-03	247	103	5	EFO_0011015, MONDO_0004975
Disease	eosinophil count	EXOC6 AKT3 SYT17 PPP1R3A PTPRC POLI HFM1 SKAP2 WIPF2 NOS2 HSPA4 RSBN1L IP6K2	2.03e-03	1488	103	13	EFO_0004842
Disease	nucleotide measurement	AKT3 BBX ENPEP	2.15e-03	73	103	3	EFO_0010513
Disease	free cholesterol to total lipids in large LDL percentage	AFF1 RFLNA POLK	2.24e-03	74	103	3	EFO_0022280
Disease	Headache, HbA1c measurement	NBEAL1 HSPA4	2.43e-03	21	103	2	EFO_0004541, HP_0002315
Disease	Mammary Carcinoma, Human	LEPR STAT5A KMT2D EFNA1 MMP1 NOS2 CDH5	2.47e-03	525	103	7	C4704874
Disease	Mammary Neoplasms, Human	LEPR STAT5A KMT2D EFNA1 MMP1 NOS2 CDH5	2.47e-03	525	103	7	C1257931
Disease	Corneal astigmatism	SYT17 AOAH MED13L	2.51e-03	77	103	3	EFO_1002040
Disease	Mammary Neoplasms	LEPR STAT5A KMT2D EFNA1 MMP1 NOS2 CDH5	2.53e-03	527	103	7	C1458155
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	MPP3 AFF1 HSPA4 CDH17	2.54e-03	162	103	4	EFO_0004612, EFO_0007878
Disease	hypothyroidism (biomarker_via_orthology)	OTOF NGF NOS2	2.79e-03	80	103	3	DOID:1459 (biomarker_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	RHOA NOS2 CDH5	2.79e-03	80	103	3	DOID:6432 (biomarker_via_orthology)
Disease	Breast Carcinoma	LEPR STAT5A KMT2D EFNA1 MMP1 NOS2 CDH5	2.83e-03	538	103	7	C0678222
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	MPP3 AFF1 HSPA4 CDH17	2.89e-03	168	103	4	EFO_0004329, EFO_0004612
Disease	neutrophil count	PCDHA11 SEC22B LCT LEPR BBX PTPRC LGI2 NUFIP2 POLI NGF AFF1 WIPF2	3.18e-03	1382	103	12	EFO_0004833
Disease	Colorectal Carcinoma	FLNC SPTBN2 CLSTN2 PANK4 LRP1 C2CD6 MMP1 CDH5	3.23e-03	702	103	8	C0009402
Disease	smoking behavior, BMI-adjusted waist-hip ratio	WARS2 BBX RFLNA	3.43e-03	86	103	3	EFO_0004318, EFO_0007788
Disease	interstitial lung disease (is_marker_for)	NGF NOS2	3.44e-03	25	103	2	DOID:3082 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IRDLEKSFTQKYPPV	UXS1	66	Q8NBZ7
FQPSVAKRYVDQKFV	PPP2R5B	181	Q15173
REPSYFEIPTKEFQQ	CEP170	236	Q5SW79
EEFEKKFNSLPQYSP	BBX	691	Q8WY36
PGYPIKITFDRFKTE	CSMD2	786	Q7Z408
VPDYVKKATPFFISL	AGMO	36	Q6ZNB7
QFPSPVVVESDFVKY	GSDME	66	O60443
VNAFKELVRKYPQSP	ASPH	361	Q12797
FAPTFKEPAYKAVVT	CLSTN2	156	Q9H4D0
PFFTQTKYTFVVPED	CDH5	256	P33151
PFKPQVTSETDTRYF	AKT3	421	Q9Y243
YEKFKPDLQKPRVFS	MTUS2	696	Q5JR59
KPASLTVEFVPFFYQ	NBEAL1	186	Q6ZS30
PFLDVTFYKETKSPF	RAD51AP2	191	Q09MP3
KDLVKTYPPFVNFFE	ECT2	541	Q9H8V3
IFKFIIPNVVKYSPN	LDHA	116	P00338
PFKDVDSDKYSVFPT	AOAH	181	P28039
VFPYEAKKDRVAVQP	NOS2	1131	P35228
YRFPSVSKLKPEDFD	MPPED2	136	Q15777
APAFAQPEYTVFVKE	PCDHA11	451	Q9Y5I1
ETDYFVKVVPFPSIK	IL17RD	156	Q8NFM7
FVRPYEKDEKPVNKS	MED13L	146	Q71F56
APFSKVLTFYRKEPF	HSPA4	426	P34932
VEPKATFFAVTYQIP	KIAA1671	1021	Q9BY89
KQYFFETKCRDPNPV	NGF	171	P01138
KFTPQYKGVVSVRFE	IP6K2	61	Q9UHH9
KVFFTDYGQIPKVER	LRP1	336	Q07954
KFFFPPDYQVLKVSE	KIAA1109	356	Q2LD37
IKFDEVKYFSVQVPR	C2CD6	161	Q53TS8
RPEYIEFKPKFQDCS	C2CD6	516	Q53TS8
IFRNPFYPKDVQTVT	PCNX4	416	Q63HM2
AVKYADQEVPRSPFK	FLNC	1516	Q14315
QRPSEIKDYSPYFKT	KRT16	156	P08779
PRIPKASAKFYASVV	LCT	1821	P09848
PKRYFFVVEEDNTPL	NDNF	61	Q8TB73
RVFTTQDVIYFPPKI	LEPR	326	P48357
FPCFDEPNKKATYTI	ENPEP	231	Q07075
YKIVISKFPFQDPDL	EXOC6	456	Q8TAG9
PTVYRNPESFKEKFV	HIGD2A	26	Q9BW72
EFNFPDPYSKVKQRE	PANK4	516	Q9NVE7
DQFSFKIVLVPPYQK	PPP1R3A	186	Q16821
EIPAKFRSIFKEFPY	HFM1	266	A2PYH4
ERIIPTFKYNRDVPF	DNAH6	2051	Q9C0G6
FKEQEVPDPTKYFVT	KDM1B	741	Q8NB78
YDIPVRKPAVSKFQQ	CC2D2A	1051	Q9P2K1
PFFKREVFDTYLVPI	GNPAT	266	O15228
PEKLSEKFQRFTPFT	EFNA1	101	P20827
FYKIKPLQSPAEFSV	FGL1	96	Q08830
TIPESKPFFYVNVAD	DENND11	291	A4D1U4
PYIPFFATFDSKVAK	CASQ1	206	P31415
YRFVKEKRPTISPNF	DUSP16	271	Q9BY84
DFPDIYFLPTKISTK	DNAH14	3426	Q0VDD8
SQAFSKRNKAYPPEE	SLC2A9	511	Q9NRM0
FKKYVENRPVTPVSD	KLF10	56	Q13118
PVRYYDKDTTKPISF	ENGASE	71	Q8NFI3
ANPIPKAAVYVRTFF	DHRS7C	276	A6NNS2
DFPVKVPYRKITFNP	GTF2IRD2	351	Q86UP8
DFPVKVPYRKITFNP	GTF2IRD2B	351	Q6EKJ0
YSLVDKEKLPRFPFS	CDH17	271	Q12864
KITFPSDIDPQVFYE	POLI	701	Q9UNA4
VAPNFKTEPIETKFY	RSF1	451	Q96T23
KKVPTVSRPYSFIEF	SEC22B	101	O75396
FVFRPELFDVTKPYI	METTL4	86	Q8N3J2
AFPPVSLVYTKKQAF	OTOF	946	Q9HC10
SKDQFPEVYVPTVFE	RHOC	26	P08134
LRTSEFKPYIIFVKP	MPP3	491	Q13368
PPQTKYFEINYVRKE	CFAP221	96	Q4G0U5
KNYDSKIPENSEFPF	RSBN1L	311	Q6PCB5
FNKKYGEFFPVPESI	WARS2	196	Q9UGM6
TVRPYNPFNKKDKET	SPATA48	421	A4D263
SKDQFPEVYVPTVFE	RHOA	26	P61586
PEFGFPEKITVKQRY	TRDMT1	356	O14717
TQKPVFEERYTFEIP	SYT17	251	Q9BSW7
KFKEIYVQAPRSFTA	LGI2	501	Q8N0V4
TSKVYTIRPYFPKDE	OGA	711	O60502
TIRPYFPKDEASVYK	OGA	716	O60502
PKDIYSSFGFPRTVK	MMP1	361	P03956
APDKRIYQFTAASPK	SKAP2	191	O75563
KTSPFELYQFFVRQP	YARS2	296	Q9Y2Z4
DYVFFKEAPFPKTQI	LARS1	636	Q9P2J5
KPFISSRTTPKDFYV	SERPINA4	221	P29622
EKFFRPLPESYDQFK	PNLDC1	266	Q8NA58
KPKLAFFSEIQRYPV	PPP1R42	286	Q7Z4L9
FQHIPYIKEPKSVFR	IARS2	846	Q9NSE4
GRPNPVYKETFVFKV	SYT14P1	111	Q58G82
LIYVFPDRPKDEVFS	STAT5A	666	P42229
FPEEFKAIYLRSKPS	CTSO	76	P43234
KPLPEDYRQQTFEKT	AFF1	311	P51825
TAPYKYPRKVEFVSE	ACSM1	541	Q08AH1
FPKAYELEKRTSPQV	NUFIP2	561	Q7Z417
FPNQVLKPFLEDSKY	MRPL10	126	Q7Z7H8
SFNSYRTVEKPPKFT	SPTBN2	346	O15020
SIVPYEKKFDTFIPL	SPATS1	231	Q496A3
YQASKFFEAQIPKTP	RPAP2	141	Q8IXW5
EKHFQDKVFYAPVPT	RFLNA	116	Q6ZTI6
IVPPNFDKYRAVSKE	POLK	166	Q9UBT6
KPVSIATNRSVYFKP	NUP153	371	P49790
KVFSEVSPLYTPFTK	TBCK	271	Q8TEA7
PRALKFVDVAVYFSP	ZNF689	26	Q96CS4
LKKFTTVNPEFYNEP	ZGRF1	1446	Q86YA3
PEEYKHFQRIYPSKT	WIPF2	411	Q8TF74
EFQSIPRVFSKFPIK	PTPRC	656	P08575
VRIVYYDPDVFKTKP	THEGL	431	P0DJG4
LPNETFTDYPKQIFR	TRPC7	416	Q9HCX4
TFPDPNVKYVFRTEN	USF1	41	P22415
FPRPSYQEEAVTKFL	TPP1	416	O14773
FRNPKTSFYSKEVPQ	AGL	751	P35573
KVKEPEPQYFRFEGV	KMT2D	1576	O14686
NVFVDKPAFPEYKVS	KCNH8	191	Q96L42
KIYRQPPDRFKFTSV	NEB	2931	P20929
YRQPPDKLKFTSVTD	NEB	3176	P20929