Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPLAC

ADAMTS2 ADAMTS14

1.66e-0419192IPR010909
DomainPLAC

ADAMTS2 ADAMTS14

1.66e-0419192PS50900
DomainADAM_spacer1

ADAMTS2 ADAMTS14

2.45e-0423192IPR010294
DomainADAM_spacer1

ADAMTS2 ADAMTS14

2.45e-0423192PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS2 ADAMTS14

2.67e-0424192IPR013273
Domain-

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

4.76e-046791953.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

5.26e-04694195IPR013087
DomainPep_M12B_propep

ADAMTS2 ADAMTS14

7.10e-0439192PF01562
DomainPeptidase_M12B_N

ADAMTS2 ADAMTS14

7.10e-0439192IPR002870
DomainDISINTEGRIN_1

ADAMTS2 ADAMTS14

7.47e-0440192PS00427
DomainReprolysin

ADAMTS2 ADAMTS14

7.47e-0440192PF01421
DomainADAM_MEPRO

ADAMTS2 ADAMTS14

7.47e-0440192PS50215
DomainDISINTEGRIN_2

ADAMTS2 ADAMTS14

7.47e-0440192PS50214
DomainPeptidase_M12B

ADAMTS2 ADAMTS14

7.47e-0440192IPR001590
DomainDisintegrin_dom

ADAMTS2 ADAMTS14

7.85e-0441192IPR001762
DomainZINC_FINGER_C2H2_2

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

8.69e-04775195PS50157
DomainZINC_FINGER_C2H2_1

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

8.79e-04777195PS00028
DomainZnf_C2H2-like

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

9.80e-04796195IPR015880
DomainZnf_C2H2

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

1.03e-03805195IPR007087
DomainZnF_C2H2

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

1.05e-03808195SM00355
DomainTSP_1

ADAMTS2 ADAMTS14

1.85e-0363192PF00090
DomainTSP1_rpt

ADAMTS2 ADAMTS14

1.96e-0365192IPR000884
DomainTSP1

ADAMTS2 ADAMTS14

1.96e-0365192PS50092
DomainTSP1

ADAMTS2 ADAMTS14

1.96e-0365192SM00209
Domain-

ADAMTS2 ADAMTS14

3.03e-03811923.40.390.10
DomainMetalloPept_cat_dom

ADAMTS2 ADAMTS14

3.03e-0381192IPR024079
DomainZINC_PROTEASE

ADAMTS2 ADAMTS14

4.40e-0398192PS00142
Domainzf-C2H2

KLF6 ZNF771 ZNF513 ZBTB22

4.67e-03693194PF00096
DomainZnf_FYVE_PHD

ZFYVE26 BRD1

9.64e-03147192IPR011011
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS2 ADAMTS14

3.31e-0439102MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS2 ADAMTS14

3.31e-0439102M27417
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

ADAMTS2 ADAMTS14

8.11e-0461102MM14637
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

ADAMTS2 ADAMTS14

9.77e-0467102M26999
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS2 ADAMTS14

1.01e-0368102M27303
PathwayREACTOME_COLLAGEN_FORMATION

ADAMTS2 ADAMTS14

1.26e-0376102MM14573
PathwayREACTOME_COLLAGEN_FORMATION

ADAMTS2 ADAMTS14

1.75e-0390102M631
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS2 ADAMTS14

2.56e-03109102MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS2 ADAMTS14

2.65e-03111102M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS2 ADAMTS14

4.36e-03143102M27275
Pubmed

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.

ADAMTS2 ADAMTS14

4.18e-07223237929635
Pubmed

ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis.

ADAMTS2 ADAMTS14

4.18e-07223235316211
Pubmed

Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.

ADAMTS2 ADAMTS14

4.18e-07223229649548
Pubmed

Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.

ADAMTS2 ADAMTS14

1.25e-06323211741898
Pubmed

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.

ADAMTS2 ADAMTS14

1.25e-06323225863161
Pubmed

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.

ADAMTS2 ADAMTS14

1.25e-06323231152061
Pubmed

Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.

ADAMTS2 ADAMTS14

2.51e-06423222205175
Pubmed

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.

ADAMTS2 ADAMTS14

4.18e-06523223491141
Pubmed

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

ADAMTS2 ADAMTS14

6.26e-06623216556917
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

ADAMTS2 ADAMTS14

4.37e-051523238871984
Pubmed

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

ZC3H11A ZC3HAV1L

5.66e-051723221628590
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ZC3H11B PLAG1 ZC3H11A ZBTB22

6.26e-0533223437433992
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

ZNF771 ZC3HAV1L BRD1

2.31e-0418223332239614
CytobandEnsembl 112 genes in cytogenetic band chr10q22

OIT3 ADAMTS14

4.85e-03208232chr10q22
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS2 ADAMTS14

1.58e-041918250
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

KLF6 ZNF771 PLAG1 ZNF513 ZBTB22

5.42e-0471818528
GeneFamilyZinc fingers CCCH-type

ZC3H11B ZC3H11A

5.46e-043518273
Diseasebody fat distribution

ADAMTS2 ZC3H11B ADAMTS14

5.06e-04202233EFO_0004341
DiseaseCorneal astigmatism

ZC3H11B NECAB2

1.64e-0377232EFO_1002040
Diseaseattention deficit hyperactivity disorder

CSMD2 ADAMTS2 LINC02906

2.54e-03354233EFO_0003888
DiseaseAstigmatism

ADAMTS2 ZC3H11B

4.52e-03129232HP_0000483
Diseasesporadic amyotrophic lateral sclerosis

KLF6 ZFYVE26

5.30e-03140232EFO_0001357
Diseasepeak expiratory flow

PLAG1 ASB14 BRD1

6.58e-03498233EFO_0009718

Protein segments in the cluster

PeptideGeneStartEntry
MRRKGRCHRGSAARH

BRD1

1

O95696
HRPVCRARMCDAHLR

CSMD2

396

Q7Z408
HLCRLKIRKCMGRLH

ASB14

536

A6NK59
KYGCRRRRDHHMVQR

ADAMTS14

871

Q8WXS8
CRRRLDHKMVHRGFC

ADAMTS2

881

O95450
DTRHMVKRCDERHGR

LINC02906

31

E5RJ46
MHKARLRGHCARAGK

DHRS4L1

1

P0CG22
MLPRCGHRRVDHFLC

OR2W6P

171

Q8NHA6
RSRCAQGCHRRMRRG

OIT3

506

Q8WWZ8
CLACRKRRKRCMRHA

DKK1

111

O94907
DADCCRRHMEFRKLR

MAP4K1

331

Q92918
MKRREAVCAHRHFLG

TDRG1

1

Q3Y452
RRHMVVHTGRKDFLC

PLAG1

201

Q6DJT9
RHMLRHTGEKPFRCA

ZNF513

461

Q8N8E2
HMRRRLYICAGCGRD

ZNF771

281

Q7L3S4
RCHRRCGGRVKTEHK

PROM2

131

Q8N271
QEGRCFRQVCRFRHM

ZC3H11A

41

O75152
QEGRCFRRVCRFRHM

ZC3H11B

41

A0A1B0GTU1
FTMFNRRHHCRRCGR

ZFYVE26

1826

Q68DK2
FMRHRGHCERRHRLG

ZBTB22

556

O15209
HFCRRHMLGKCPNRD

ZC3HAV1L

106

Q96H79
RRRVHRCHFNGCRKV

KLF6

196

Q99612
MCERAARLCRAGAHR

NECAB2

1

Q7Z6G3