Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	semaphorin receptor complex	ERBB2 PLXNB1 PLXNB3	5.68e-06	13	58	3	GO:0002116
Domain	FAM47	FAM47C FAM47B	5.47e-05	4	57	2	PF14642
Domain	FAM47	FAM47C FAM47B	5.47e-05	4	57	2	IPR032743
Domain	ABC1	COQ8A COQ8B	9.10e-05	5	57	2	PF03109
Domain	UbiB_dom	COQ8A COQ8B	9.10e-05	5	57	2	IPR004147
Domain	Plexin_cytopl	PLXNB1 PLXNB3	3.25e-04	9	57	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB1 PLXNB3	3.25e-04	9	57	2	IPR013548
Domain	Plexin	PLXNB1 PLXNB3	3.25e-04	9	57	2	IPR031148
Domain	Znf_CCCH	ZC3H14 TOE1 MBNL3	7.38e-04	58	57	3	IPR000571
Domain	ZF_C3H1	ZC3H14 TOE1 MBNL3	7.38e-04	58	57	3	PS50103
Domain	DSRM	ADAD2 DGCR8	1.51e-03	19	57	2	SM00358
Domain	dsrm	ADAD2 DGCR8	1.68e-03	20	57	2	PF00035
Domain	DS_RBD	ADAD2 DGCR8	1.85e-03	21	57	2	PS50137
Domain	TRYPSIN_SER	PRSS53 KLK13 PRSS36	2.62e-03	90	57	3	IPR033116
Domain	IPT	PLXNB1 PLXNB3	3.06e-03	27	57	2	SM00429
Domain	-	ADAD2 DGCR8	3.06e-03	27	57	2	3.30.160.20
Domain	dsRBD_dom	ADAD2 DGCR8	3.29e-03	28	57	2	IPR014720
Domain	TRYPSIN_HIS	PRSS53 KLK13 PRSS36	3.84e-03	103	57	3	IPR018114
Domain	TIG	PLXNB1 PLXNB3	4.02e-03	31	57	2	PF01833
Domain	Sema	PLXNB1 PLXNB3	4.02e-03	31	57	2	SM00630
Domain	Semap_dom	PLXNB1 PLXNB3	4.02e-03	31	57	2	IPR001627
Domain	Sema	PLXNB1 PLXNB3	4.02e-03	31	57	2	PF01403
Domain	SEMA	PLXNB1 PLXNB3	4.02e-03	31	57	2	PS51004
Domain	TRYPSIN_SER	PRSS53 KLK13 PRSS36	4.16e-03	106	57	3	PS00135
Domain	TRYPSIN_HIS	PRSS53 KLK13 PRSS36	4.27e-03	107	57	3	PS00134
Domain	PSI	PLXNB1 PLXNB3	4.28e-03	32	57	2	PF01437
Domain	IPT	PLXNB1 PLXNB3	4.28e-03	32	57	2	IPR002909
Domain	Plexin_repeat	PLXNB1 PLXNB3	4.28e-03	32	57	2	IPR002165
Domain	Peptidase_S1A	PRSS53 KLK13 PRSS36	4.98e-03	113	57	3	IPR001314
Domain	TRYPSIN_DOM	PRSS53 KLK13 PRSS36	5.23e-03	115	57	3	PS50240
Domain	Tryp_SPc	PRSS53 KLK13 PRSS36	5.48e-03	117	57	3	SM00020
Domain	Trypsin	PRSS53 KLK13 PRSS36	6.02e-03	121	57	3	PF00089
Domain	Trypsin_dom	PRSS53 KLK13 PRSS36	6.02e-03	121	57	3	IPR001254
Domain	Peptidase_S1_PA	PRSS53 KLK13 PRSS36	6.30e-03	123	57	3	IPR009003
Domain	PX	NISCH SNX19	7.97e-03	44	57	2	SM00312
Domain	PSI	PLXNB1 PLXNB3	7.97e-03	44	57	2	IPR016201
Domain	PSI	PLXNB1 PLXNB3	8.69e-03	46	57	2	SM00423
Domain	WW	HECW2 DGCR8	9.06e-03	47	57	2	PF00397
Domain	ZnF_C3H1	ZC3H14 MBNL3	9.43e-03	48	57	2	SM00356
Domain	WW	HECW2 DGCR8	9.43e-03	48	57	2	SM00456
Domain	zf-CCCH	TOE1 MBNL3	9.82e-03	49	57	2	PF00642
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	ERBB2 PLXNB1 PLXNB3	1.87e-04	51	31	3	MM14967
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	ERBB2 PLXNB1	2.54e-04	11	31	2	MM15046
Pathway	REACTOME_UBIQUINOL_BIOSYNTHESIS	COQ8A COQ8B	3.60e-04	13	31	2	MM17216
Pathway	REACTOME_UBIQUINOL_BIOSYNTHESIS	COQ8A COQ8B	3.60e-04	13	31	2	M27142
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	ERBB2 PLXNB1 PLXNB3	3.66e-04	64	31	3	M7923
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	ERBB2 PLXNB1	4.83e-04	15	31	2	MM15037
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	ERBB2 PLXNB1	8.68e-04	20	31	2	M18415
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	ERBB2 PLXNB1	1.25e-03	24	31	2	M2243
Pathway	REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS	BCAN B3GAT2	1.25e-03	24	31	2	MM14773
Pathway	REACTOME_METABOLISM_OF_COFACTORS	COQ8A COQ8B	1.36e-03	25	31	2	M27855
Pathway	REACTOME_METABOLISM_OF_COFACTORS	COQ8A COQ8B	1.36e-03	25	31	2	MM15574
Pathway	REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS	BCAN B3GAT2	1.47e-03	26	31	2	M708
Pubmed	Vitamin D receptor and estrogen receptor gene polymorphisms in postmenopausal Danish women: no relation to bone markers or serum lipoproteins.	ERBB2 VDR	2.83e-06	2	59	2	11910656
Pubmed	Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia.	ERBB2 VDR	2.83e-06	2	59	2	15083213
Pubmed	Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.	COQ8A COQ8B	2.83e-06	2	59	2	27499294
Pubmed	Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.	DRD2 DGCR8	2.83e-06	2	59	2	24904170
Pubmed	Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.	ERBB2 PLXNB1	2.83e-06	2	59	2	15210733
Pubmed	ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.	ERBB2 PLXNB1	2.83e-06	2	59	2	22378040
Pubmed	Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.	SOX8 PLXNB3 VDR	5.18e-06	20	59	3	31291246
Pubmed	A subcellular map of the human kinome.	COQ8A COQ8B	1.69e-05	4	59	2	33988507
Pubmed	Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development.	PLXNB1 PLXNB3	1.69e-05	4	59	2	15147296
Pubmed	ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.	ERBB2 PLXNB1	1.69e-05	4	59	2	18025083
Pubmed	Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.	PLXNB1 PLXNB3	2.82e-05	5	59	2	12183458
Pubmed	Plexin-B3 is a functional receptor for semaphorin 5A.	PLXNB1 PLXNB3	2.82e-05	5	59	2	15218527
Pubmed	Interplay between scatter factor receptors and B plexins controls invasive growth.	PLXNB1 PLXNB3	2.82e-05	5	59	2	15184888
Pubmed	The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.	VPS72 COQ8A COQ8B	3.75e-05	38	59	3	33913477
Pubmed	Suppression of bone formation by osteoclastic expression of semaphorin 4D.	ERBB2 PLXNB1	5.91e-05	7	59	2	22019888
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNB1 PLXNB3	7.87e-05	8	59	2	15661641
Pubmed	Primary Coenzyme Q10 Deficiency Overview	COQ8A COQ8B	1.26e-04	10	59	2	28125198
Pubmed	Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.	BCAN B3GAT2	1.26e-04	10	59	2	20950796
Pubmed	A census of human transcription factors: function, expression and evolution.	ZBTB38 ZNF398 SOX8 LHX6 RFX4 TOE1 MBNL3 VDR	1.43e-04	908	59	8	19274049
Pubmed	Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.	ERBB2 PLXNB1	1.54e-04	11	59	2	25315821
Pubmed	Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.	PLXNB1 PLXNB3	1.85e-04	12	59	2	12123608
Pubmed	A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.	PLXNB1 PLXNB3	1.85e-04	12	59	2	20478304
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNB1 PLXNB3	1.85e-04	12	59	2	21270798
Pubmed	An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.	PLXNB1 PLXNB3	2.18e-04	13	59	2	24572910
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNB1 PLXNB3	2.18e-04	13	59	2	10520995
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FRY LPAR5 HECW2 COQ8B QRICH2 MEGF10 PLXNB3	2.42e-04	736	59	7	29676528
Pubmed	Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.	DGCR8 LHX6	2.54e-04	14	59	2	24101523
Pubmed	Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.	PLXNB1 PLXNB3	2.93e-04	15	59	2	21122816
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FRY ZBTB38 VPS72 NISCH DGCR8 SHROOM2 ZNF785 TRIM59 PLXNB3	2.97e-04	1285	59	9	35914814
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNB1 PLXNB3	3.79e-04	17	59	2	11683995
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNB1 PLXNB3	3.79e-04	17	59	2	17626059
Pubmed	Genetically distinct subsets within ANCA-associated vasculitis.	SERPINA11 F8	4.25e-04	18	59	2	22808956
Pubmed	Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.	DRD2 LHX6	4.75e-04	19	59	2	10393115
Pubmed	Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.	DRD2 LHX6	5.27e-04	20	59	2	17460091
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NID2 ERBB2 VPS72 COQ8A CHD5 COQ8B TENT2 ZNF574	5.70e-04	1116	59	8	31753913
Pubmed	The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.	ZNF398 ZNF446	6.39e-04	22	59	2	31403225
Pubmed	Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2.	DRD2 LHX6	6.39e-04	22	59	2	33821423
Pubmed	Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.	ERBB2 PLXNB1	7.00e-04	23	59	2	21035938
Pubmed	Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.	DRD2 DGCR8	7.62e-04	24	59	2	21821099
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	ERBB2 DRD2 VDR	8.34e-04	108	59	3	19956635
Pubmed	Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.	DRD2 LHX6	8.96e-04	26	59	2	12724834
Pubmed	Identification of Arx transcriptional targets in the developing basal forebrain.	SOX8 SHROOM2	1.04e-03	28	59	2	18799476
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	DRD2 SOX8	1.12e-03	29	59	2	31491374
GeneFamily	Plexins	PLXNB1 PLXNB3	1.79e-04	9	41	2	683
ToppCell	Posterior_cortex-Macroglia\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	BCAN SOX8 TRIM59 MEGF10 PLXNB3	3.55e-06	175	59	5	8bc7a3856d04692989b2a1675ea6d9392261d55a
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX8 TRIM59 MEGF10 PLXNB1 PLXNB3	4.91e-06	187	59	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN TRIM59 MEGF10 PLXNB1 PLXNB3	5.04e-06	188	59	5	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN TRIM59 MEGF10 PLXNB1 PLXNB3	5.17e-06	189	59	5	784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN TRIM59 MEGF10 PLXNB1 PLXNB3	5.17e-06	189	59	5	37ecbd73408d462b47d7e5611f203143e08a2689
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1 PLXNB3	5.30e-06	190	59	5	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN TRIM59 MEGF10 PLXNB1 PLXNB3	5.30e-06	190	59	5	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1 PLXNB3	5.30e-06	190	59	5	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAD2 NID2 FRY HECW2 VEGFD	6.32e-06	197	59	5	a312d9cf4ced949307eb9620be4eed926300b892
ToppCell	Macroglial\|World / cells hierarchy compared to all cells using T-Statistic	PAPLN TRIM59 MEGF10 PLXNB1 PLXNB3	6.80e-06	200	59	5	e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	BCAN SOX8 RFX4 B3GAT2 MEGF10	6.80e-06	200	59	5	3a954d9d542e52c9b181f0850a09b1bff0a0c82d
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZBTB38 PAPLN SHROOM2 QRICH2	6.63e-05	164	59	4	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN1 HECW2 B3GNT3 LHX6	7.61e-05	170	59	4	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN1 HECW2 B3GNT3 LHX6	7.61e-05	170	59	4	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	TCGA-Brain\|World / Sample_Type by Project: Shred V9	BCAN SOX8 RFX4 B3GAT2	7.61e-05	170	59	4	f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCell	Frontal_cortex-Macroglia\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BCAN SOX8 TRIM59 PLXNB3	8.15e-05	173	59	4	ac70145e093ef0df43811e7c67a865ccdd45a5e3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCAN SOX8 RFX4 MEGF10	8.15e-05	173	59	4	23e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCell	10x3'2.3-week_17-19-Neuro-stroma-schwann_cells\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	NID2 ERBB2 BCAN PLXNB3	8.52e-05	175	59	4	8b010220cdfb680ec839572f4933adfb85045ea6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HECW2 LHX6 VEGFD F8	8.52e-05	175	59	4	90302e8a44858ef3b2a165b88284d4788d591a99
ToppCell	10x3'2.3-week_17-19-Neuro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	NID2 ERBB2 BCAN PLXNB3	8.52e-05	175	59	4	0b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell	10x3'2.3-week_17-19-Neuro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	NID2 ERBB2 BCAN PLXNB3	8.52e-05	175	59	4	bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LPAR5 B3GNT3 VEGFD	8.83e-05	65	59	3	f14b28214f80ed23501ab28ff254c206f70d77b2
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BCAN SOX8 B3GAT2 PLXNB3	9.10e-05	178	59	4	b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCell	Entopeduncular-Macroglia\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SOX8 TRIM59 MEGF10 PLXNB3	9.29e-05	179	59	4	f61974710a60aa0618fdb30d864fb9bc7c05ef21
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CHD5 B3GNT3 PRSS36	9.50e-05	180	59	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	Thalamus-Macroglia\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX8 TRIM59 MEGF10 PLXNB3	9.70e-05	181	59	4	4f62b63854a4e9fea6e839f0340e78392c66fb0e
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 ZBTB38 HECW2 F8	9.70e-05	181	59	4	4df7972f88117108698efd06b124b232f8588981
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	9.70e-05	181	59	4	0c3f469bed108994ed696230e3c30343f7a301d3
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 ZBTB38 HECW2 F8	9.70e-05	181	59	4	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX8 TRIM59 MEGF10 PLXNB3	1.01e-04	183	59	4	5472cdce6d99314d229418412acf1fff6340db7d
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX8 TRIM59 MEGF10 PLXNB3	1.03e-04	184	59	4	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	wk_08-11-Epithelial-PNS-COL20A1+_Schwann\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SOX8 RFX4 MEGF10 PLXNB3	1.06e-04	185	59	4	abec2a49fe0f0fa4cba49347207a1ee317333657
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX8 TRIM59 MEGF10 PLXNB3	1.06e-04	185	59	4	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 FOXRED2 DGCR8 PLXNB3	1.10e-04	187	59	4	8e8b147258982b359447add5027318f5b6d51963
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	1.10e-04	187	59	4	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.10e-04	187	59	4	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.10e-04	187	59	4	93c78fc7f126132eb84feb47be2c4e8c568b9e91
ToppCell	droplet-Fat-SCAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM2 CYSRT1 PLXNB1 ZNF574	1.10e-04	187	59	4	5fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCell	droplet-Fat-SCAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM2 CYSRT1 PLXNB1 ZNF574	1.10e-04	187	59	4	766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCell	droplet-Fat-SCAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM2 CYSRT1 PLXNB1 ZNF574	1.10e-04	187	59	4	f49d06600060deeb2fc1b1da5b93496535f20104
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.10e-04	187	59	4	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.10e-04	187	59	4	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	1.10e-04	187	59	4	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.12e-04	188	59	4	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DRC7 ADAD2 HECW2 LHX6	1.12e-04	188	59	4	5d166d9e71632edd059ff0a9f66f8763f259d40a
ToppCell	(2)_NK/T-(210)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	ERBB2 FRY LYPLA1 DGCR8	1.15e-04	189	59	4	fa72e87e1e8cd7cbddae7b47e19cf90d181820a7
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.15e-04	189	59	4	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	(2)_NK/T-(21)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	ERBB2 FRY LYPLA1 DGCR8	1.15e-04	189	59	4	b37ad24898a14a4a3b2d6cea2637de2471f76e20
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.15e-04	189	59	4	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.17e-04	190	59	4	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	1.17e-04	190	59	4	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.17e-04	190	59	4	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.17e-04	190	59	4	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FRY B4GALNT3 SOX8 MEGF10	1.19e-04	191	59	4	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM59 MEGF10 PLXNB1 PLXNB3	1.19e-04	191	59	4	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN MEGF10 PLXNB1 PLXNB3	1.19e-04	191	59	4	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FRY B4GALNT3 SOX8 MEGF10	1.19e-04	191	59	4	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN MEGF10 PLXNB1 PLXNB3	1.19e-04	191	59	4	a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	1.22e-04	192	59	4	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.22e-04	192	59	4	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 PLXNB1 PLXNB3	1.22e-04	192	59	4	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.24e-04	193	59	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAPLN RFX4 MEGF10 PLXNB1	1.24e-04	193	59	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRY HECW2 LHX6 VEGFD	1.29e-04	195	59	4	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX8 TRIM59 MEGF10 PLXNB3	1.32e-04	196	59	4	f068ce40bf35021baf1468ae9ce30a92162eb14d
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 SOX8 MEGF10 PLXNB3	1.32e-04	196	59	4	e6adcfe1a00d4910e0b92848f8a80224e0d6db12
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX8 TRIM59 MEGF10 PLXNB3	1.37e-04	198	59	4	43a2ce64fa309bac89a44ea320e87ae2cc39f782
Drug	Phenformin hydrochloride [834-28-6]; Up 200; 16.6uM; PC3; HT_HG-U133A	NPHP1 RIN1 FOXRED2 BCAN B3GNT3 VDR	9.50e-06	196	57	6	4283_UP
Drug	STOCK1N-35874; Down 200; 14uM; PC3; HT_HG-U133A	RIN1 DRD2 ZNF358 DGCR8 B3GNT3 VDR	9.77e-06	197	57	6	6583_DN
Disease	primary coenzyme Q10 deficiency 4 (implicated_via_orthology)	COQ8A COQ8B	3.54e-06	2	56	2	DOID:0070241 (implicated_via_orthology)
Disease	nephrotic syndrome type 9 (implicated_via_orthology)	COQ8A COQ8B	3.54e-06	2	56	2	DOID:0080391 (implicated_via_orthology)
Disease	coenzyme Q10 deficiency disease (implicated_via_orthology)	COQ8A COQ8B	7.38e-05	7	56	2	DOID:0050730 (implicated_via_orthology)
Disease	Barrett's esophagus (is_implicated_in)	B3GAT2 VDR	1.92e-04	11	56	2	DOID:9206 (is_implicated_in)
Disease	Alzheimer disease, dementia	LHX6 RFX4	2.31e-04	12	56	2	MONDO_0001627, MONDO_0004975
Disease	Malignant neoplasm of breast	NID2 ERBB2 VPS72 NISCH CHD5 SHROOM2 PLXNB1 VDR	9.04e-04	1074	56	8	C0006142
Disease	nephrotic syndrome (implicated_via_orthology)	COQ8A COQ8B	9.51e-04	24	56	2	DOID:1184 (implicated_via_orthology)
Disease	Bradycardia	DRD2 NISCH	1.12e-03	26	56	2	C0428977
Disease	ovarian carcinoma (is_marker_for)	KLK13 VEGFD	1.30e-03	28	56	2	DOID:4001 (is_marker_for)
Disease	peak expiratory flow	FRY ZBTB38 B4GALNT3 SOX8 VDR	2.53e-03	498	56	5	EFO_0009718
Disease	developmental disorder of mental health (implicated_via_orthology)	PLXNB1 PLXNB3	3.93e-03	49	56	2	DOID:0060037 (implicated_via_orthology)
Disease	anti-neutrophil antibody associated vasculitis	SERPINA11 F8	4.41e-03	52	56	2	EFO_0004826
Disease	Hypotension	DRD2 NISCH	4.58e-03	53	56	2	C0020649

Protein segments in the cluster

Peptide	Gene	Start	Entry
YIRCRHPPPGSHLLY	VDR	366	P11473
PREYVNARHCLPCHP	ERBB2	551	P04626
CHDPPTLSRAIHTRP	ADAD2	431	Q8NCV1
SSYHLHCLNPPLPEI	CHD5	436	Q8TDI0
PYAHISIPRAHLRPD	CYSRT1	11	A8MQ03
IPKSHLRHVLPDCPY	B4GALNT3	336	Q6L9W6
FHTHYVPDIVRCVPP	TENT2	121	Q6PIY7
RKHDPPLSSIPCLHY	DGCR8	341	Q8WYQ5
RPLYCSPITAHLLHR	DCLRE1B	46	Q9H816
TLTYPYHRSRPQHLP	QRICH2	1561	Q9H0J4
PSSSVTHRIPVYPHR	RFX4	581	Q33E94
SIPHPEYRRSPTHLN	KLK13	106	Q9UKR3
PPHALLHPSYCQSPR	HECW2	1151	Q9P2P5
HIPCHYDLLPVRDSS	MEGF10	1106	Q96KG7
GALTIPCHVHYLRPP	BCAN	51	Q96GW7
PCHVHYLRPPPSRRA	BCAN	56	Q96GW7
SHLCPEPPETRVSHL	FAM47C	676	Q5HY64
EPHISYPPLHERALR	MAGEA2	296	P43356
SVLPCPDYRPTHRLH	LPAR5	11	Q9H1C0
FEICPYDPHHRIPLS	GTSF1L	6	Q9H1H1
TRHHLYCEPPVEQPL	PLXNB1	1431	O43157
TRTHLYCEPPAHAPQ	PLXNB3	1201	Q9ULL4
ALGYPRHCPRHCPRE	FAM205A	1311	Q6ZU69
SHLCPEPPETRVSHL	FAM47B	281	Q8NA70
HCRLPYTAPPVHLKA	LHX6	331	Q9UPM6
PPIIARYIRLHPTHY	F8	2161	P00451
LHPALSVPPRRDYCV	FOXRED2	21	Q8IWF2
YQVCRHAPRHPSFPT	NID2	706	Q14112
SRPVCLPHPEHYFLP	PRSS36	426	Q5K4E3
LPHPEHYFLPGSRCR	PRSS36	431	Q5K4E3
RLSHRLPHICSQPPL	C18orf15	61	Q96N68
PSTHLHVPTPRRYKR	B3GAT2	136	Q9NPZ5
PYSLSPRPSVGHIHR	DNAJB12	271	Q9NXW2
RHRLVPPPEETYSLH	COQ8A	596	Q8NI60
HRLCPPPEETYALHR	COQ8B	476	Q96D53
YRHCRHFPLLQDVPP	B3GNT3	86	Q9Y2A9
SHLCPDRVPLFLHPL	DRC7	106	Q8IY82
RCTRENCKYLHPPPH	MBNL3	61	Q9NUK0
SSHIKYICPHAPVRP	LYPLA1	46	O75608
ERTRYSPIPPSHHQL	DRD2	291	P14416
YLPETITPRGPLHRC	FRY	1626	Q5TBA9
YHDCVLPLLHSTRLP	NPHP1	656	O15259
SLPFRSHPIIPHFLC	OR10P1	166	Q8NGE3
YHRLPPGALAHRLPT	RIN1	681	Q13671
GRHPPLYSDHSPLCA	SHROOM2	426	Q13796
PCFHSPRRPYASPLL	SOX8	406	P57073
ASLRPLCLPYPDHHL	PRSS53	396	Q2L4Q9
VHYEYHLPLRRPSPG	PAPLN	291	O95428
PSHAYPVRCLLPSAH	PAPLN	746	O95428
PRHQLSEPAPAYHRI	SERPINA11	36	Q86U17
HLRVHNSTERPFPCP	ZNF398	416	Q8TD17
HRRIHTGERPYPCPD	ZNF574	756	Q6ZN55
IPSHLPACPSLRHVA	NISCH	1121	Q9Y2I1
CPHLHPVLRRPTLTD	nan	26	Q5BKY6
AYCRATAPHPAVHSP	SNX19	191	Q92543
FPHHPRRSLTGPRSY	ZNF446	381	Q9NWS9
PHRHLTSRPYACELC	ZBTB38	1001	Q8NAP3
VCPVTHRPALYRDPV	VPS72	291	Q15906
CLPTAPRHPYSIIRR	VEGFD	191	O43915
DCTFYHPTINVPPRH	ZC3H14	711	Q6PJT7
IDYRCCLPPATHRPH	TOE1	281	Q96GM8
HPDIVTCPEHYRQPL	TRIM59	91	Q8IWR1
IHRRIHTGEKPYPCP	ZNF785	301	A8K8V0
HLRTHTGERPYPCPQ	ZNF358	281	Q9NW07