Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DAG_kinase_N	DGKB DGKG	4.89e-05	3	76	2	PF14513
Domain	DAG_kinase_typeI_N	DGKB DGKG	4.89e-05	3	76	2	IPR029477
Domain	-	DGKB DGKG	4.89e-05	3	76	2	1.10.238.110
Domain	VGCC_alpha2	CACNA2D1 CACNA2D2	9.75e-05	4	76	2	PF08473
Domain	VDCC_a2/dsu	CACNA2D1 CACNA2D2	9.75e-05	4	76	2	IPR013680
Domain	GFP	HMCN2 NID1	9.75e-05	4	76	2	IPR009017
Domain	G2F	HMCN2 NID1	9.75e-05	4	76	2	PF07474
Domain	G2_nidogen/fibulin_G2F	HMCN2 NID1	9.75e-05	4	76	2	IPR006605
Domain	NIDOGEN_G2	HMCN2 NID1	9.75e-05	4	76	2	PS50993
Domain	VWA_N	CACNA2D1 CACNA2D2	1.62e-04	5	76	2	IPR013608
Domain	VPS10	SORCS2 SORCS1	1.62e-04	5	76	2	SM00602
Domain	VWA_N	CACNA2D1 CACNA2D2	1.62e-04	5	76	2	PF08399
Domain	Sortilin_C	SORCS2 SORCS1	1.62e-04	5	76	2	PF15901
Domain	Sortilin-Vps10	SORCS2 SORCS1	1.62e-04	5	76	2	PF15902
Domain	VPS10	SORCS2 SORCS1	1.62e-04	5	76	2	IPR006581
Domain	Sortilin_N	SORCS2 SORCS1	1.62e-04	5	76	2	IPR031778
Domain	Sortilin_C	SORCS2 SORCS1	1.62e-04	5	76	2	IPR031777
Domain	SEFIR	TRAF3IP2 IL17RA	2.43e-04	6	76	2	PF08357
Domain	SEFIR_dom	TRAF3IP2 IL17RA	2.43e-04	6	76	2	IPR013568
Domain	SEFIR	TRAF3IP2 IL17RA	2.43e-04	6	76	2	PS51534
Domain	PKD	SORCS2 SORCS1	3.39e-04	7	76	2	PF00801
Domain	PKD/Chitinase_dom	SORCS2 SORCS1	5.77e-04	9	76	2	IPR022409
Domain	PKD	SORCS2 SORCS1	5.77e-04	9	76	2	SM00089
Domain	Sialidases	SORCS2 SORCS1	5.77e-04	9	76	2	IPR011040
Domain	VWF_A	CACNA2D1 HMCN2 CACNA2D2 SEC24B	7.11e-04	99	76	4	IPR002035
Domain	DAGK_acc	DGKB DGKG	7.20e-04	10	76	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKB DGKG	7.20e-04	10	76	2	IPR000756
Domain	DAGKa	DGKB DGKG	7.20e-04	10	76	2	SM00045
Domain	PKD	SORCS2 SORCS1	8.78e-04	11	76	2	PS50093
Domain	PKD_dom	SORCS2 SORCS1	8.78e-04	11	76	2	IPR000601
Domain	-	SORCS2 SORCS1	8.78e-04	11	76	2	2.60.40.670
Domain	Ig_I-set	HMCN2 IGSF9 KIRREL2 DSCAML1 LRIT1	1.06e-03	190	76	5	IPR013098
Domain	I-set	HMCN2 IGSF9 KIRREL2 DSCAML1 LRIT1	1.06e-03	190	76	5	PF07679
Domain	DAGKc	DGKB DGKG	1.44e-03	14	76	2	SM00046
Domain	Diacylglycerol_kinase_cat_dom	DGKB DGKG	1.66e-03	15	76	2	IPR001206
Domain	DAGK_cat	DGKB DGKG	1.66e-03	15	76	2	PF00781
Domain	DAGK	DGKB DGKG	1.66e-03	15	76	2	PS50146
Domain	NAD/diacylglycerol_kinase	DGKB DGKG	2.14e-03	17	76	2	IPR016064
Domain	IGc2	HMCN2 IGSF9 KIRREL2 DSCAML1 LRIT1	2.70e-03	235	76	5	SM00408
Domain	Ig_sub2	HMCN2 IGSF9 KIRREL2 DSCAML1 LRIT1	2.70e-03	235	76	5	IPR003598
Domain	-	CACNA2D1 CACNA2D2 SEC24B	3.41e-03	74	76	3	3.40.50.410
Domain	fn3	FN1 IGSF9 DSCAML1 LRIT1	4.31e-03	162	76	4	PF00041
Domain	VWFA	CACNA2D1 HMCN2 CACNA2D2	4.55e-03	82	76	3	PS50234
Domain	VWA	CACNA2D1 HMCN2 CACNA2D2	4.87e-03	84	76	3	SM00327
Domain	FN3	FN1 IGSF9 DSCAML1 LRIT1	6.87e-03	185	76	4	SM00060
Pubmed	Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.	FN1 ACAN NID1	1.01e-06	9	81	3	15296947
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TPR ZHX3 GTF2A1 PHC3 CAND1 SEC24B PEX14 HEATR1 EIF3C LRBA WNK1 STAT1	1.69e-06	934	81	12	33916271
Pubmed	Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis.	TRAF3IP2 IL17RA	5.36e-06	2	81	2	30076642
Pubmed	Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage.	FN1 ACAN	5.36e-06	2	81	2	21224775
Pubmed	Increased Act1/IL-17R expression in Hirschsprung's disease.	TRAF3IP2 IL17RA	5.36e-06	2	81	2	27660002
Pubmed	A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation.	TRAF3IP2 IL17RA	5.36e-06	2	81	2	22045852
Pubmed	αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation.	FN1 NID1	5.36e-06	2	81	2	33141174
Pubmed	Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.	FN1 ACAN NID1	9.68e-06	18	81	3	12571105
Pubmed	Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter.	ATXN1 CTBP2	1.60e-05	3	81	2	21315774
Pubmed	Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling.	TRAF3IP2 IL17RA	1.60e-05	3	81	2	29080697
Pubmed	An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F.	TRAF3IP2 IL17RA	1.60e-05	3	81	2	32601099
Pubmed	Sca-1+ cardiac fibroblasts promote development of heart failure.	ATXN1 IL17RA	1.60e-05	3	81	2	29953616
Pubmed	Presynaptic α2δ subunits are key organizers of glutamatergic synapses.	CACNA2D1 CACNA2D2	1.60e-05	3	81	2	33782113
Pubmed	Macrophages participate in IL-17-mediated inflammation.	TRAF3IP2 IL17RA	1.60e-05	3	81	2	22161142
Pubmed	The three sorCS genes are differentially expressed and regulated by synaptic activity.	SORCS2 SORCS1	1.60e-05	3	81	2	15009648
Pubmed	The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.	CACNA2D1 CACNA2D2	1.60e-05	3	81	2	20080692
Pubmed	Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.	SORCS2 SORCS1	1.60e-05	3	81	2	28827148
Pubmed	ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.	TRAF3IP2 IL17RA	1.60e-05	3	81	2	33723527
Pubmed	The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains.	FN1 NID1	1.60e-05	3	81	2	9278415
Pubmed	Spatiotemporal expression analysis of the growth factor receptor SorCS3.	SORCS2 SORCS1	1.60e-05	3	81	2	24715575
Pubmed	A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans.	TRAF3IP2 IL17RA	1.60e-05	3	81	2	32350852
Pubmed	A human MAP kinase interactome.	HIPK3 TPR GTF2A1 HIVEP1 ATXN1 ADNP2 WNK1 STAT1	1.81e-05	486	81	8	20936779
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TPR NCOR1 KANSL2 PATZ1 CTBP2 HEATR1 RNASEH1 RFX1 LENG9 STAT1	3.03e-05	857	81	10	25609649
Pubmed	cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland.	FN1 NID1	3.20e-05	4	81	2	11419941
Pubmed	Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP.	FN1 NID1	3.20e-05	4	81	2	15522896
Pubmed	Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization.	CACNA2D1 CACNA2D2	3.20e-05	4	81	2	19596051
Pubmed	High IFN-γ and low SLPI mark severe asthma in mice and humans.	IL17RA STAT1	3.20e-05	4	81	2	26121748
Pubmed	The genes for the human VPS10 domain-containing receptors are large and contain many small exons.	SORCS2 SORCS1	3.20e-05	4	81	2	11499680
Pubmed	A multi-method assessment of bone maintenance and loss in an Imperial Roman population: Implications for future studies of age-related bone loss in the past.	TRAF3IP2 IL17RA	3.20e-05	4	81	2	28581022
Pubmed	Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.	NCOR1 ATXN1	3.20e-05	4	81	2	16121196
Pubmed	The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.	TRAF3IP2 IL17RA	3.20e-05	4	81	2	17277779
Pubmed	Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis.	TRAF3IP2 IL17RA	3.20e-05	4	81	2	24343647
Pubmed	Derivation of pluripotent stem cells from nascent undifferentiated teratoma.	FUT4 DND1	3.20e-05	4	81	2	30529251
Pubmed	IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia.	IL17RA STAT1	3.20e-05	4	81	2	23392574
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TPR PHC3 AMER1 STARD8 FN1 RIPPLY3 HEATR1 WNK1 PLA2G15 STAT1 MAN1B1	4.23e-05	1084	81	11	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCOR1 SORCS2 ADNP2 DSCAML1	5.25e-05	87	81	4	12465718
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TPR CAND1 STARD8 IPO8 PLEKHG6 NOA1 PEX14 CTBP2 HEATR1 ARAP2	5.30e-05	916	81	10	32203420
Pubmed	The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling.	TRAF3IP2 IL17RA	5.33e-05	5	81	2	23737552
Pubmed	Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.	FN1 ACAN	5.33e-05	5	81	2	16061471
Pubmed	Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.	DGKB DGKG	5.33e-05	5	81	2	22627129
Pubmed	NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3.	TRAF3IP2 IL17RA	5.33e-05	5	81	2	28219902
Pubmed	IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.	TRAF3IP2 IL17RA	5.33e-05	5	81	2	37725983
Pubmed	Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.	FN1 NID1	5.33e-05	5	81	2	11493006
Pubmed	Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6.	TRAF3IP2 IL17RA	5.33e-05	5	81	2	25202827
Pubmed	IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.	TRAF3IP2 IL17RA	5.33e-05	5	81	2	30962593
Pubmed	Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.	CACNA2D1 CACNA2D2	5.33e-05	5	81	2	23402298
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TRAF3IP2 PTPDC1 AMER1 TRAFD1 IPO8 PATZ1 SEC24B CTBP2 HEATR1 WNK1 NPHP4 RFX1	5.39e-05	1321	81	12	27173435
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR NCOR1 PHC3 HIVEP1 CTBP2 LRBA RFX1	5.58e-05	418	81	7	34709266
Pubmed	Bioinformatics and cellular signaling.	TRAF3IP2 IL16 HIVEP1 FN1 PATZ1	6.90e-05	182	81	5	15102471
Pubmed	Functional proteomics mapping of a human signaling pathway.	HIPK3 NCOR1 HIVEP1 FN1 NID1 CTBP2 EIF3C RFX1	7.18e-05	591	81	8	15231748
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR ZHX3 NCOR1 PHC3 KANSL2 HIVEP1 TRAFD1 EIF3C RFX1	7.99e-05	774	81	9	15302935
Pubmed	A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.	NCOR1 STAT1	7.99e-05	6	81	2	15852015
Pubmed	Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.	FUT4 DND1	7.99e-05	6	81	2	20736371
Pubmed	Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.	TRAF3IP2 IL17RA	7.99e-05	6	81	2	29101209
Pubmed	Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.	TRAF3IP2 IL17RA	7.99e-05	6	81	2	19825828
Pubmed	The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.	FN1 NID1	7.99e-05	6	81	2	11956183
Pubmed	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.	NCOR1 PATZ1	7.99e-05	6	81	2	16491076
Pubmed	IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.	TRAF3IP2 IL17RA	7.99e-05	6	81	2	28561022
Pubmed	IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.	TRAF3IP2 IL17RA	7.99e-05	6	81	2	20554964
Pubmed	Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.	CACNA2D1 CACNA2D2	7.99e-05	6	81	2	30683685
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZHX3 NCOR1 GTF2A1 HIVEP1 ATXN1 PATZ1 RFX1 LENG9 STAT1	1.11e-04	808	81	9	20412781
Pubmed	A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.	NID1 KIRREL2	1.12e-04	7	81	2	27430022
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	FN1 NID1	1.12e-04	7	81	2	10716744
Pubmed	Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.	TRAF3IP2 IL17RA	1.12e-04	7	81	2	21982598
Pubmed	Integrins are required for the differentiation of visceral endoderm.	FN1 NID1	1.12e-04	7	81	2	19118216
Pubmed	alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.	FN1 NID1	1.12e-04	7	81	2	9151677
Pubmed	Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.	FN1 NID1	1.12e-04	7	81	2	9501082
Pubmed	Human transcription factor protein interaction networks.	ZHX3 NCOR1 PHC3 KANSL2 HIVEP1 ATXN1 SEC24B TLX3 CTBP2 EIF3C RFX1 STAT1	1.14e-04	1429	81	12	35140242
Pubmed	The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.	FN1 NID1	1.49e-04	8	81	2	11847210
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	CAND1 WNK1	1.49e-04	8	81	2	26286618
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NCOR1 HIVEP1 FN1 ATXN1 EIF3C KMT2E WNK1	1.63e-04	497	81	7	23414517
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIPK3 EVA1C PTPDC1 AMER1 CAND1 ATXN1 CACNA2D2 PEX14 IGSF9 CTBP2 LRBA MAN1B1	1.67e-04	1489	81	12	28611215
Pubmed	Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.	FN1 NID1	1.91e-04	9	81	2	9827803
Pubmed	Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone.	NCOR1 STAT1	1.91e-04	9	81	2	23640055
Pubmed	Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.	ZHX3 ATXN1	1.91e-04	9	81	2	12659632
Pubmed	Multiple loci identified in a genome-wide association study of prostate cancer.	IL16 CTBP2	1.91e-04	9	81	2	18264096
Pubmed	Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.	FN1 NID1	1.91e-04	9	81	2	22952693
Pubmed	Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.	IL17RA FUT4	1.91e-04	9	81	2	15780986
Pubmed	IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells.	TRAF3IP2 IL17RA	1.91e-04	9	81	2	30578323
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NCOR1 IL16 IPO8 ADNP2 LENG9 DSCAML1 STAT1 MAN1B1	2.05e-04	689	81	8	36543142
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOR1 HIVEP1 PATZ1 KIRREL2 KMT2E	2.19e-04	233	81	5	37704626
Pubmed	An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.	TRAF3IP2 IL17RA	2.38e-04	10	81	2	24120361
Pubmed	Dynamic regulatory network controlling TH17 cell differentiation.	IL17RA STAT1	2.38e-04	10	81	2	23467089
Pubmed	CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.	NCOR1 CAND1 CTBP2	2.62e-04	53	81	3	34026424
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	FN1 NID1	2.91e-04	11	81	2	7500359
Pubmed	SVEP1 is an endogenous ligand for the orphan receptor PEAR1.	FN1 NID1	2.91e-04	11	81	2	36792666
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	FN1 ACAN	2.91e-04	11	81	2	38750698
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKB DGKG	2.91e-04	11	81	2	17021016
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	FN1 ADAM15 ACAN NID1 PLA2G15	2.92e-04	248	81	5	24006456
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR NCOR1 SEC24B HEATR1 LRBA RFX1 STAT1	2.98e-04	549	81	7	38280479
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ZHX3 PHC3 HIVEP1 ADNP2 CTBP2 FAM90A1	3.41e-04	398	81	6	35016035
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	FN1 NID1	3.48e-04	12	81	2	12180907
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	HMCN2 FN1 ACAN NID1	3.86e-04	146	81	4	27068509
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	CACNA2D1 IL16 CTBP2 CFAP61 CSMD2	3.95e-04	265	81	5	19240061
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	FN1 NID1	4.11e-04	13	81	2	9833687
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	NCOR1 AMER1 CAND1 FN1 SEC24B PEX14 LRBA ARAP2	4.58e-04	777	81	8	35844135
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	NCOR1 CAND1 SEC24B BCAT2 MAN1B1	4.76e-04	276	81	5	28319085
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	NID1 HEATR1	4.79e-04	14	81	2	11472062
Pubmed	DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.	CTBP2 DSCAML1	4.79e-04	14	81	2	19945391
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	FN1 NID1	4.79e-04	14	81	2	20858856
Interaction	TBL1XR1 interactions	NCOR1 CAND1 ATXN1 SEC24B TLX3 DGKG IL17RA MAN1B1	7.78e-07	192	78	8	int:TBL1XR1
Interaction	FAM90A26 interactions	FAM90A26 FAM90A1	1.48e-05	2	78	2	int:FAM90A26
Interaction	PRR20B interactions	GTF2A1 HIVEP1 ATXN1 PATZ1 TLX3	2.59e-05	90	78	5	int:PRR20B
Interaction	PRR20C interactions	GTF2A1 HIVEP1 ATXN1 PATZ1 TLX3	2.59e-05	90	78	5	int:PRR20C
Interaction	PRR20D interactions	GTF2A1 HIVEP1 ATXN1 PATZ1 TLX3	2.59e-05	90	78	5	int:PRR20D
Interaction	PRR20E interactions	GTF2A1 HIVEP1 ATXN1 PATZ1 TLX3	4.52e-05	101	78	5	int:PRR20E
Interaction	PRR20A interactions	GTF2A1 HIVEP1 ATXN1 PATZ1 TLX3	6.51e-05	109	78	5	int:PRR20A
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HMCN2 IGSF9 KIRREL2 DSCAML1 LRIT1	1.28e-04	161	55	5	593
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKB DGKG	4.03e-04	10	55	2	1178
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	BCAT2 HEATR1 WNK1	5.00e-04	51	55	3	870
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX3 ADNP2	9.30e-04	15	55	2	529
GeneFamily	Fibronectin type III domain containing	FN1 IGSF9 DSCAML1 LRIT1	1.42e-03	160	55	4	555
GeneFamily	Immunoglobulin like domain containing	HMCN2 IGSF9 KIRREL2 DSCAML1	2.81e-03	193	55	4	594
GeneFamily	Calcium voltage-gated channel subunits	CACNA2D1 CACNA2D2	2.82e-03	26	55	2	253
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	TRAF3IP2 TPR PTPDC1 CACNA2D1 PHC3 ATXN1 DGKB DGKG IL17RA RFTN2 GRIN3A LRBA KMT2E	1.16e-05	834	79	13	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	TRAF3IP2 TPR ZHX3 CACNA2D1 PHC3 ATXN1 DGKG NID1 IL17RA RFTN2 GRIN3A KMT2E	1.63e-05	734	79	12	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_k-means-cluster#2_top-relative-expression-ranked_1000	CACNA2D1 ATXN1 SLC26A7 DGKB NID1 ARAP2	3.27e-05	163	79	6	gudmap_kidney_P0_JuxtaGlom_Ren1_k2_1000
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA2D1 TLX3 DGKB GPAT2 SORCS1	1.31e-05	168	80	5	a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CACNA2D1 FN1 NID1 RFTN2 SORCS1	1.60e-05	175	80	5	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	CACNA2D1 RAB33A RFTN2 KIRREL2 CSMD2	2.31e-05	189	80	5	b46adb47768a7b6d801c457d7ba65508edfc36a5
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	CACNA2D1 ACAN DGKB DGKG NID1	2.43e-05	191	80	5	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	HIPK3 ADAM15 NOA1 HEATR1 ARAP2	2.62e-05	194	80	5	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	IL16 LRBA WNK1 STAT1 ARAP2	2.96e-05	199	80	5	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 FN1 ACAN RFTN2 DSCAML1	3.03e-05	200	80	5	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 FN1 ACAN RFTN2 DSCAML1	3.03e-05	200	80	5	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 FN1 ACAN NID1 RFTN2	3.03e-05	200	80	5	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	TRAF3IP2 GTF2A1 TRAFD1 PATZ1 ADAM15 PLA2G15 STAT1	4.48e-06	193	78	7	6964_DN
Drug	Loracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ZHX3 NCOR1 FN1 PATZ1 IL17RA NPHP4 PLA2G15	5.30e-06	198	78	7	5492_DN
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Up 200; 11uM; MCF7; HT_HG-U133A	RAB33A STARD8 TRAFD1 FN1 ACAN NID1 IL17RA	5.30e-06	198	78	7	3237_UP
Disease	Candidiasis, Chronic Mucocutaneous	TRAF3IP2 IL17RA STAT1	3.01e-07	6	74	3	C0006845
Disease	Malignant neoplasm of breast	NCOR1 GTF2A1 STARD8 FN1 NOA1 SH2D3A DGKG ACCS LRBA WNK1 STAT1 SORCS1	1.39e-05	1074	74	12	C0006142
Disease	coronary aneurysm	GRIN3A CSMD2 MAN1B1	9.35e-05	35	74	3	EFO_1000881
Disease	smoking status measurement, forced expiratory volume	PKHD1 DGKG	3.36e-04	11	74	2	EFO_0004314, EFO_0006527
Disease	extrapulmonary tuberculosis	ADAM15 DGKB	4.03e-04	12	74	2	MONDO_0000368
Disease	attention function measurement	SORCS2 HEATR1 LRBA CSMD2	5.32e-04	148	74	4	EFO_0007636
Disease	comparative body size at age 10, self-reported	ACAN TLX3 PKHD1 CTBP2 WNK1 PLA2G15	6.57e-04	420	74	6	EFO_0009819
Disease	alcohol drinking	HEATR1 KMT2E ARAP2	1.12e-03	81	74	3	EFO_0004329
Disease	physical activity	PKHD1 GRIN3A ARAP2	1.43e-03	88	74	3	EFO_0003940
Disease	cortical surface area measurement	ZHX3 NCOR1 CACNA2D1 ADAM15 TLX3 PKHD1 IGSF9 CTBP2 RFTN2 STAT1	1.89e-03	1345	74	10	EFO_0010736
Disease	RS-10-hydroxywarfarin measurement	SLC26A7 IL17RA DSCAML1	1.94e-03	98	74	3	EFO_0803330
Disease	lumbar disc degeneration	HIVEP1 SLC26A7	2.25e-03	28	74	2	EFO_0004994
Disease	glucose metabolism disease (implicated_via_orthology)	DGKB DGKG	2.25e-03	28	74	2	DOID:4194 (implicated_via_orthology)
Disease	neutrophil count	GTF2A1 HIVEP1 TRAFD1 ATXN1 STXBP5 DGKG IL17RA LRBA PSPH KMT2E	2.31e-03	1382	74	10	EFO_0004833
Disease	myeloid white cell count	GTF2A1 KANSL2 FN1 ATXN1 STXBP5 DGKG IL17RA KMT2E	2.38e-03	937	74	8	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGVSGSRIHLVQPPP	CFAP61	856	Q8NHU2
LPIPPNGHRIGTLSV	CSMD2	2661	Q7Z408
IIPGGIPVTHNLPTV	CTBP2	406	P56545
LLGLPPRPQPQVLVH	CACNA2D2	1131	Q9NY47
PVPLRPENVVVLNGG	ACCS	156	Q96QU6
QGPPIISRIQDLHLP	ADAM15	161	Q13444
PPQEIPHGNLIRLAV	C14orf28	176	Q4W4Y0
REGLLHNGVPIPVPP	BRPF3	1101	Q9ULD4
KPVGITHGIPQLPRV	AMER1	1076	Q5JTC6
NPKIGGLPLIPIQHE	ARAP2	1556	Q8WZ64
GSLPQHLVIPGTQPL	ATXN1	476	P54253
HLVIPGTQPLLIPVG	ATXN1	481	P54253
DLGLVPRQVHIPPNP	CFAP157	461	Q5JU67
VGTNILPVNQPVRPG	ADNP2	571	Q6IQ32
NGHAVPPLVPKVLVG	RAB33A	136	Q14088
RHPPVVLVPGDLGNQ	PLA2G15	36	Q8NCC3
PVIQPVGQRKHLPAS	RFTN2	81	Q52LD8
PRGQPAPQPLHTLVL	IL17RA	656	Q96F46
PQTAVRHQGPEPLLV	FAM90A1	211	Q86YD7
PGQPVPEIGLLHTVA	FUT4	391	P22083
LQLEVHVPPQIAGPR	HMCN2	2256	Q8NDA2
PGALTQHIPVLVPGI	CAND1	466	Q86VP6
PLAALGPGVLAVPQH	LENG9	131	Q96B70
PIHQGPAVPTAVIPL	NID1	926	P14543
GPVPIIVSRHPDPQV	IL16	431	Q14005
PPLHLLPQEVGGRQE	RIPPLY3	131	P57055
GPPNLPGQTTIQVRV	MEX3D	266	Q86XN8
SPVPGQIPIHRAQVP	KMT2E	1831	Q8IZD2
QTPSQLLIEPHPPRG	LRBA	2476	P50851
PQTVPAQILVGHKPR	PTPDC1	411	A2A3K4
VHQVPVGLNPRLLPS	HIPK3	1161	Q9H422
LPLPASPVVHIGPVQ	PHC3	456	Q8NDX5
RHVPQIPKPAVLATG	LRIT1	381	Q9P2V4
IQRGPPHLQIRPPSQ	MAN1B1	161	Q9UKM7
LPPRGVQDLHVGVRP	NPHP4	1281	O75161
LVVQVTAVPGQPHLP	ACAN	461	P16112
NQLGIRIHQDIPLPP	GRIN3A	1036	Q8TCU5
PLPQVSRHQEPILNG	PATZ1	521	Q9HBE1
PPHEGPLQGLVASRI	PLEKHG6	6	Q3KR16
HQLRVGERQPLLGPP	EIF3C	716	Q99613
IIPTPGTHPLLVLVN	DGKG	426	P49619
PTPQPVQHPGLRRQV	EVA1C	11	P58658
VQHPGLRRQVEPPGQ	EVA1C	16	P58658
VLLHPNLQPKPIGVG	CACNA2D1	521	P54289
HPVPLTGRIQILPNS	DSCAML1	736	Q8TD84
VIPVNLPGEHGQRLP	FN1	941	P02751
LLVVPQPGPGLTHLA	GPAT2	526	Q6NUI2
QGLQVTPVPGTHPLL	DGKB	426	Q9Y6T7
NVGKHPPVAILPLGT	DGKB	511	Q9Y6T7
VPGIIAPDNVHVIQP	MS4A18	11	Q3C1V0
QVVIPGHPVPFSGLI	DND1	291	Q8IYX4
IHVLPTNRGRITPVP	KANSL2	6	Q9H9L4
QLHVLVPPEAPQVLG	KIRREL2	116	Q6UWL6
IPVIRGLVGNPLPSV	HEATR1	1601	Q9H583
PPLNGVILPGVVRQS	BCAT2	286	O15382
GAVHVNDRIVPQPPL	SEC24B	1131	O95487
GLLLAPGHQGPQRPV	NOA1	276	Q8NC60
LERIQLPHNPGPITV	IPO8	801	O15397
QGIPPNHPVTVLIRV	FER1L6	1346	Q2WGJ9
PTHPQRPLVLKTGVQ	STAT1	326	P42224
IAPGHVSVIRPPQNL	TRAFD1	506	O14545
PVQPLTVQGLQPVHV	RFX1	261	P22670
PGELPRVPRHVQIQL	PPP1R3E	106	Q9H7J1
PHQVITNLPEGVRLP	NCOR1	1011	O75376
PQPAVRHQGPEPLLV	FAM90A26	211	D6RGX4
PLTPPRGLQVSIQGE	SORCS2	776	Q96PQ0
LHNQVLPPPTRVISG	SPATA31E1	281	Q6ZUB1
PPLGGHFRIQLPNTV	PKHD1	786	P08F94
GPATQVVPVQPPHLI	PEX14	81	O75381
LPPGGEQRLLQPVIV	STXBP5	831	Q5T5C0
GVPPLIHVQRTGQPL	STARD8	571	Q92502
QPLPGASVRGLHPVQ	TRAF3IP2	306	O43734
PGHPLNVGIRLPGRQ	RNASEH1	166	O60930
VIQQVLAPLPGGISP	GTF2A1	201	P52655
VQRLIAEQPPHLTPG	PSPH	76	P78330
TIHAPPQELGPPVQR	TPR	2086	P12270
GPQNRPLEPQVLHTL	SH2D3A	291	Q9BRG2
PQPAVRHQGPEPLLV	FAM90A2P	211	Q658T7
QLPGLLPQPVLAGVV	IGSF9	726	Q9P2J2
GVIRVPAHRPLPGAV	TLX3	86	O43711
ISQPGGLHPLVIPSV	WNK1	1561	Q9H4A3
VVGHIPQGIPSPRAP	SLC26A7	286	Q8TE54
PGQHILVAVLPGLPT	SORCS1	1016	Q8WY21
HAANGPLIGTVPVLP	ZHX3	251	Q9H4I2
PVPGGLQPQILHYRV	HIVEP1	1001	P15822