Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5B KDM5D KDM5A KDM5C

3.38e-116264GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5B KDM5D KDM5A KDM5C

1.57e-108264GO:0032453
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5B KDM5D KDM5A KDM5C

4.53e-0828264GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5B KDM5D KDM5A KDM5C

6.94e-0831264GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5B KDM5D KDM5A KDM5C

7.92e-0832264GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM5B KDM5D KDM5A KDM5C

2.96e-0744264GO:0032451
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5B KDM5D KDM5A KDM5C

1.45e-0665264GO:0016706
GeneOntologyMolecularFunctiondioxygenase activity

KDM5B KDM5D KDM5A KDM5C

7.51e-0698264GO:0051213
GeneOntologyMolecularFunctionfatty acid elongase activity

ELOVL4 ELOVL2

3.41e-057262GO:0009922
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

KDM5B KDM5D KDM5A KDM5C

1.09e-04194264GO:0016705
GeneOntologyMolecularFunctionhistone modifying activity

KDM5B KDM5D KDM5A KDM5C

2.07e-04229264GO:0140993
GeneOntologyMolecularFunctionchannel activity

GJC3 CLCN5 CHRNA9 KCNH1

4.46e-03525264GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GJC3 CLCN5 CHRNA9 KCNH1

4.49e-03526264GO:0022803
GeneOntologyMolecularFunctioncargo receptor activity

CUBN LRP1B

5.45e-0385262GO:0038024
GeneOntologyBiologicalProcessfatty acid elongation, unsaturated fatty acid

ELOVL4 ELOVL2

3.45e-057272GO:0019368
GeneOntologyBiologicalProcessfatty acid elongation, polyunsaturated fatty acid

ELOVL4 ELOVL2

3.45e-057272GO:0034626
GeneOntologyBiologicalProcessfatty acid elongation, monounsaturated fatty acid

ELOVL4 ELOVL2

3.45e-057272GO:0034625
GeneOntologyBiologicalProcessfatty acid elongation, saturated fatty acid

ELOVL4 ELOVL2

4.60e-058272GO:0019367
GeneOntologyBiologicalProcessvery long-chain fatty acid biosynthetic process

ELOVL4 ELOVL2

1.28e-0413272GO:0042761
GeneOntologyBiologicalProcessfatty acid elongation

ELOVL4 ELOVL2

1.71e-0415272GO:0030497
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA biosynthetic process

ELOVL4 ELOVL2

2.78e-0419272GO:0035338
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

ELOVL4 TM9SF2 ELOVL2

4.71e-04117273GO:0030148
GeneOntologyBiologicalProcessfatty-acyl-CoA biosynthetic process

ELOVL4 ELOVL2

5.68e-0427272GO:0046949
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA metabolic process

ELOVL4 ELOVL2

5.68e-0427272GO:0035336
GeneOntologyBiologicalProcessvery long-chain fatty acid metabolic process

ELOVL4 ELOVL2

9.56e-0435272GO:0000038
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

ELOVL4 TM9SF2 ELOVL2

1.11e-03157273GO:0046467
GeneOntologyCellularComponentSMN complex

DDX20 GEMIN8

8.77e-0511272GO:0032797
GeneOntologyCellularComponentGemini of coiled bodies

DDX20 GEMIN8

1.05e-0412272GO:0097504
GeneOntologyCellularComponentSMN-Sm protein complex

DDX20 GEMIN8

2.71e-0419272GO:0034719
DomainLys_sp_deMease-like_dom

KDM5B KDM5D KDM5A KDM5C

2.50e-124254IPR013637
DomainPLU-1

KDM5B KDM5D KDM5A KDM5C

2.50e-124254PF08429
Domainzf-C5HC2

KDM5B KDM5D KDM5A KDM5C

1.25e-115254PF02928
DomainZnf_C5HC2

KDM5B KDM5D KDM5A KDM5C

1.25e-115254IPR004198
DomainJmjN

KDM5B KDM5D KDM5A KDM5C

5.21e-1010254PF02375
DomainJmjN

KDM5B KDM5D KDM5A KDM5C

5.21e-1010254SM00545
DomainJMJN

KDM5B KDM5D KDM5A KDM5C

5.21e-1010254PS51183
DomainJmjN

KDM5B KDM5D KDM5A KDM5C

5.21e-1010254IPR003349
Domain-

KDM5B KDM5D KDM5A KDM5C

3.37e-09152541.10.150.60
DomainARID

KDM5B KDM5D KDM5A KDM5C

3.37e-0915254PF01388
DomainBRIGHT

KDM5B KDM5D KDM5A KDM5C

3.37e-0915254SM00501
DomainARID_dom

KDM5B KDM5D KDM5A KDM5C

3.37e-0915254IPR001606
DomainARID

KDM5B KDM5D KDM5A KDM5C

3.37e-0915254PS51011
DomainJmjC

KDM5B KDM5D KDM5A KDM5C

2.60e-0824254PF02373
DomainJMJC

KDM5B KDM5D KDM5A KDM5C

8.75e-0832254PS51184
DomainJmjC_dom

KDM5B KDM5D KDM5A KDM5C

8.75e-0832254IPR003347
DomainJmjC

KDM5B KDM5D KDM5A KDM5C

9.95e-0833254SM00558
DomainZinc_finger_PHD-type_CS

KDM5B KDM5D KDM5A KDM5C

1.60e-0665254IPR019786
DomainPHD

KDM5B KDM5D KDM5A KDM5C

2.85e-0675254PF00628
DomainZnf_PHD-finger

KDM5B KDM5D KDM5A KDM5C

3.51e-0679254IPR019787
DomainPHD

KDM5B KDM5D KDM5A KDM5C

5.64e-0689254SM00249
DomainZnf_PHD

KDM5B KDM5D KDM5A KDM5C

6.17e-0691254IPR001965
DomainZF_PHD_2

KDM5B KDM5D KDM5A KDM5C

7.32e-0695254PS50016
DomainZF_PHD_1

KDM5B KDM5D KDM5A KDM5C

7.63e-0696254PS01359
DomainELO_CS

ELOVL4 ELOVL2

2.57e-056252IPR030457
DomainELO

ELOVL4 ELOVL2

3.60e-057252PF01151
DomainELO

ELOVL4 ELOVL2

3.60e-057252PS01188
DomainELO_fam

ELOVL4 ELOVL2

3.60e-057252IPR002076
DomainZnf_FYVE_PHD

KDM5B KDM5D KDM5A KDM5C

4.10e-05147254IPR011011
DomainCUB

CUBN ATRNL1

1.95e-0349252PF00431
DomainCUB

CUBN ATRNL1

2.03e-0350252SM00042
Domain-

CUBN ATRNL1

2.19e-03522522.60.120.290
DomainCUB

CUBN ATRNL1

2.27e-0353252PS01180
DomainCUB_dom

CUBN ATRNL1

2.62e-0357252IPR000859
Domain-

KDM5B KDM5D KDM5A KDM5C

2.79e-034492543.30.40.10
DomainEGF_extracell

LRP1B ATRNL1

2.90e-0360252IPR013111
DomainEGF_2

LRP1B ATRNL1

2.90e-0360252PF07974
DomainZnf_RING/FYVE/PHD

KDM5B KDM5D KDM5A KDM5C

3.02e-03459254IPR013083
DomainEGF_3

CUBN LRP1B ATRNL1

3.69e-03235253PS50026
DomainEGF

CUBN LRP1B ATRNL1

3.69e-03235253SM00181
DomainEGF-like_dom

CUBN LRP1B ATRNL1

4.34e-03249253IPR000742
DomainEGF_1

CUBN LRP1B ATRNL1

4.63e-03255253PS00022
DomainEGF-like_CS

CUBN LRP1B ATRNL1

4.94e-03261253IPR013032
DomainEGF_2

CUBN LRP1B ATRNL1

5.16e-03265253PS01186
DomainEGF_CA

CUBN LRP1B

5.87e-0386252PF07645
DomainEGF_Ca-bd_CS

CUBN LRP1B

7.41e-0397252IPR018097
DomainEGF_CA

CUBN LRP1B

7.71e-0399252PS01187
DomainASX_HYDROXYL

CUBN LRP1B

7.86e-03100252PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

CUBN LRP1B

8.79e-03106252IPR000152
DomainEGF_CA

CUBN LRP1B

1.15e-02122252SM00179
DomainEGF-like_Ca-bd_dom

CUBN LRP1B

1.19e-02124252IPR001881
DomainEGF

CUBN LRP1B

1.22e-02126252PF00008
DomainGrowth_fac_rcpt_

CUBN LRP1B

1.83e-02156252IPR009030
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5B KDM5D KDM5A KDM5C

4.33e-0829184MM14934
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5B KDM5D KDM5A KDM5C

4.13e-0750184M27232
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM5B KDM5D KDM5A KDM5C

6.13e-05175184MM14941
PathwayWP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS

ELOVL4 ELOVL2

1.01e-0412182MM17077
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM5B KDM5D KDM5A KDM5C

3.35e-04272184M29619
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ELOVL4 ELOVL2

4.18e-0424182M1016
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ELOVL4 ELOVL2

9.99e-0437182M729
PathwayWP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS

ELOVL4 ELOVL2

1.61e-0347182M39853
PathwayREACTOME_SARS_COV_2_MODULATES_HOST_TRANSLATION_MACHINERY

DDX20 GEMIN8

1.89e-0351182M45019
PathwayWP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS

ELOVL4 ELOVL2

1.97e-0352182MM15920
PathwayREACTOME_SNRNP_ASSEMBLY

DDX20 GEMIN8

2.12e-0354182M29594
PathwayREACTOME_SNRNP_ASSEMBLY

DDX20 GEMIN8

2.44e-0358182MM14736
PathwayREACTOME_CHROMATIN_MODIFICATIONS_DURING_THE_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT

KDM5B KDM5A

3.53e-0370182M48028
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5B KDM5D KDM5A KDM5C

2.88e-13427416541399
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5B KDM5D KDM5A KDM5C

2.05e-101327424619213
Pubmed

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

KDM5B KDM5A KDM5C

4.17e-10327338230606
Pubmed

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

KDM5B KDM5A KDM5C

4.17e-10327326645689
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5B KDM5D KDM5C

1.67e-09427317320160
Pubmed

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

KDM5B KDM5A KDM5C

8.33e-09627321960634
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5B KDM5D KDM5A KDM5C

1.16e-083327426864203
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5B KDM5D KDM5A KDM5C

5.96e-084927434368113
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM5B KDM5D KDM5A KDM5C

1.11e-075727418022353
Pubmed

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

KDM5B KDM5A KDM5C

4.71e-072027323637629
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM5B KDM5A KDM5C

5.50e-072127327626377
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5D KDM5C

5.80e-07227232081420
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5D KDM5C

5.80e-07227210441747
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5D KDM5C

5.80e-07227216416087
Pubmed

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.

KDM5B KDM5A

5.80e-07227234184733
Pubmed

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

KDM5B KDM5A

5.80e-07227230472020
Pubmed

Mapping membrane lipids in the developing and adult mouse retina under physiological and pathological conditions using mass spectrometry.

ELOVL4 ELOVL2

5.80e-07227233465374
Pubmed

Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis.

KDM5B KDM5A

5.80e-07227236509829
Pubmed

KDM5 lysine demethylases are involved in maintenance of 3'UTR length.

KDM5B KDM5A

5.80e-07227228138513
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5D KDM5C

5.80e-0722729060413
Pubmed

Alcohol-associated fibrosis in females is mediated by female-specific activation of lysine demethylases KDM5B and KDM5C.

KDM5B KDM5C

5.80e-07227235468265
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5D KDM5C

5.80e-0722727524912
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

ELOVL4 ACHE ELOVL2

1.21e-062727325269881
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5D KDM5C

1.74e-0632727544442
Pubmed

Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.

KDM5B KDM5A

1.74e-06327216645588
Pubmed

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

KDM5A KDM5C

1.74e-06327217320161
Pubmed

Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?

CUBN CLCN5

1.74e-06327237594671
Pubmed

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

KDM5B KDM5C

1.74e-06327227214403
Pubmed

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.

CUBN CLCN5

1.74e-06327212815097
Pubmed

KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas.

KDM5A KDM5C

1.74e-06327237880235
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5D KDM5C

3.48e-06427232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5D KDM5C

3.48e-0642727951230
Pubmed

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.

KDM5B KDM5A

3.48e-06427222615382
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KDM5B KDM5A KDM5C

5.41e-064427324183668
Pubmed

MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.

KDM5B KDM5C

5.80e-06527226621457
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KDM5B KDM5D KDM5A KDM5C

6.47e-0615727430186101
Pubmed

DNA-binding properties of ARID family proteins.

KDM5B KDM5A

1.22e-05727215640446
Pubmed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

KDM5B KDM5C

1.22e-05727228262558
Pubmed

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity.

DDX20 GEMIN8

1.62e-05827226908624
Pubmed

Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron.

DDX20 GEMIN8

2.08e-05927223112048
Pubmed

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

ELOVL4 ELOVL2

2.60e-051027220937905
Pubmed

A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

DDX20 GEMIN8

2.60e-051027217178713
Pubmed

The SMN complex, an assemblyosome of ribonucleoproteins.

DDX20 GEMIN8

2.60e-051027212067652
Pubmed

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

KDM5B CUBN

2.60e-051027217302988
Pubmed

Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.

ELOVL4 ELOVL2

3.18e-051127223689133
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5D KDM5C

4.50e-051327214660691
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5D KDM5C

6.06e-051527214762062
Pubmed

Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.

DDX20 GEMIN8

8.81e-051827223221635
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

KDM5D KDM5C

8.81e-051827212023983
Pubmed

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

DDX20 GEMIN8

1.33e-042227218984161
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT17 CUBN

1.59e-042427231740596
Pubmed

Biosynthesis of triacylglycerols.

ELOVL4 ELOVL2

2.17e-04282728944226
Pubmed

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.

ELOVL4 ELOVL2

2.33e-042927238485951
Pubmed

Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.

CUBN CLCN5

3.80e-043727216319116
Pubmed

The SMN interactome includes Myb-binding protein 1a.

DDX20 GEMIN8

5.88e-044627219928837
InteractionP2RY12 interactions

DDX20 TTC39A GEMIN8

6.85e-0562263int:P2RY12
InteractionRN7SL1 interactions

DDX20 GEMIN8

7.16e-0510262int:RN7SL1
InteractionKDM5A interactions

KDM5B KDM5A KDM5C

1.16e-0474263int:KDM5A
InteractionSNAPC4 interactions

KDM5B TTC38 KDM5C

1.26e-0476263int:SNAPC4
InteractionRNU2-1 interactions

DDX20 GEMIN8

1.66e-0415262int:RNU2-1
InteractionKDM5B interactions

KDM5B KDM5A KDM5C

2.84e-04100263int:KDM5B
InteractionRNU1-1 interactions

DDX20 GEMIN8

3.31e-0421262int:RNU1-1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

GJC3 ACHE

7.35e-03219272chr7q22
CytobandEnsembl 112 genes in cytogenetic band chr1q32

KDM5B KCNH1

1.26e-02290272chr1q32
GeneFamilyAT-rich interaction domain containing

KDM5B KDM5D KDM5A KDM5C

2.22e-0915224418
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5B KDM5D KDM5A KDM5C

1.72e-0824224485
GeneFamilyPHD finger proteins

KDM5B KDM5D KDM5A KDM5C

3.92e-069022488
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC39A TTC38

8.53e-03115222769
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 KDM5B TMEM45A ACHE

3.01e-0616727402c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 WDR89 CUBN LRP1B

3.46e-0617327466f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 WDR89 CUBN LRP1B

3.46e-06173274649b08a409095592cccf31883be69c754411280d
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJC3 PAQR3 GEMIN8 ELOVL2

4.61e-06186274adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCelldroplet-Skin-nan-21m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 KDM5B TMEM45A ACHE

5.12e-06191274c5ef34d138cd797029dfefaf4c52d16ba6a76c38
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR89 TMEM45A KCNH1

6.55e-05130273e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCelldroplet-Skin-nan-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 WDR89 KDM5D

6.55e-051302734c8b931987432e8bcd39029d4fa124dc383ea355
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJC3 CUBN LRP1B

7.82e-05138273c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CUBN LRP1B ATRNL1

7.99e-05139273a1945b07f177cde40e7eea03a19236ce76165857
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CHRNA9 LRP1B ATRNL1

1.00e-041502730205318a870e091add66ee4305747dda9f51510d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJC3 CUBN LRP1B

1.00e-04150273afd651c654e715414eff64cf3a37378d057a56a2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 TMEM45A ELOVL2

1.24e-041612737d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 TMEM45A ELOVL2

1.24e-04161273410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 TMEM45A ELOVL2

1.24e-0416127359ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 TMEM45A ELOVL2

1.24e-0416127371022485da6754a2b57b4c3e758e3de4c95cc292
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KDM5B GJC3 CHRNA9

1.28e-04163273edca1d1a345109dbdeb7ee5464faefab1993fdb2
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

TTC39A CLCN5 ACHE

1.40e-04168273968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR89 CUBN LRP1B

1.43e-0416927312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Skin-nan-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 TMEM45A ACHE

1.50e-041722735ca89af7406e7e1a055dd60d6f89615f69e62324
ToppCellE15.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GJC3 LRP1B ACHE

1.50e-04172273a8b33d8ebc56e442a2ad6ac7dafd0c887571bd95
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 KDM5B ACHE

1.53e-041732730f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 WDR89 CUBN

1.55e-04174273f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCelldroplet-Kidney-nan-21m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUBN TM9SF2 ELOVL2

1.61e-041762730475db3f860de1e216cbdeb886f7a75b9f4fc801
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT17 TMEM45A KCNH1

1.63e-041772739ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT17 TMEM45A KCNH1

1.63e-04177273016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJC3 GALNT17 ELOVL2

1.69e-04179273c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT17 ACHE KCNH1

1.74e-041812737af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCellfacs-Skin-Telogen-3m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 TMEM45A ACHE

1.80e-04183273ed1e0b07475f9951728682ed70b85367cf2a744d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GJC3 GALNT17 KCNH1

1.86e-041852737dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GJC3 GALNT17 KCNH1

1.89e-041862734d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GJC3 GALNT17 KCNH1

1.92e-041872735258674d0346e5c51a4b965efcdc1790c970845d
ToppCellwk_15-18-Mesenchymal-Fibroblast-Airway_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GJC3 GALNT17 KCNH1

1.98e-041892734f9608b84d135268a17455661870c46ae8554a24
ToppCellSupraBC-Differ-KC|World / shred by cell class for mouse tongue

ELOVL4 TMEM45A KDM5A

1.98e-041892736412741b88e241304033b41effca0c77a374d907
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CUBN CLCN5 LRP1B

2.11e-0419327382e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GALNT17 KCNH1 ATRNL1

2.20e-04196273676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GALNT17 ACHE ATRNL1

2.27e-0419827302d0d8a212e09c0962ab1dae6a885d26d357f66a
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

GALNT17 KCNH1 ATRNL1

2.34e-0420027348d801219bc771d6c7e151dc88ca4c179988de85
DrugE)-11-hexadecenyl acetate

KDM5D KCNH1

1.25e-062262CID005352788
DrugGalantamine

CHRNA9 ACHE

3.50e-058262DB00674
Drugazafagomine

KDM5D KDM5A KDM5C

3.71e-0557263CID011957435
Drugtrifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA

CLCN5 ACHE ATRNL1 KDM5C

5.60e-051862641004_UP
DrugDecamethonium bromide [541-22-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

TTC39A CLCN5 CHRNA9 GEMIN8

6.21e-051912644094_DN
Drugdecursinol

ACHE KCNH1

6.85e-0511262CID000442127
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A

ELOVL4 TMEM45A ELOVL2 KDM5C

7.00e-051972645226_DN
DrugAtracurium besylate [64228-81-5]; Up 200; 3.2uM; PC3; HT_HG-U133A

ELOVL4 TTC39A TTC38 PAQR3

7.00e-051972641824_UP
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

ELOVL4 TTC38 ELOVL2 KDM5C

7.14e-051982641669_DN
DrugTerazosin hydrochloride [63590-64-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A

TTC39A TMEM45A TTC38 ATRNL1

7.28e-051992646092_UP
Drugtrifluoroacetophenone

ACHE KCNH1

8.22e-0512262CID000009905
DrugAC1L9P8C

CHRNA9 ACHE

8.22e-0512262CID000450864
Drugpinene

ACHE KCNH1

9.71e-0513262CID000014896
DrugSAD-128

CHRNA9 ACHE

1.30e-0415262CID000162008
Drugbenzoquinonium

CHRNA9 ACHE

1.49e-0416262CID000009393
DrugMGA-100

KDM5D CUBN

1.90e-0418262CID000018020
Drugbenzetimide

CHRNA9 ACHE

1.90e-0418262CID000021846
DrugPNU-120596

CHRNA9 ACHE

2.12e-0419262CID000311434
Drugmethyl benzoate

KDM5D KCNH1

2.35e-0420262CID000007150
Drugoxotremorine

CLCN5 CHRNA9 ACHE

2.49e-04108263CID000004630
Drugmeproadifen

CHRNA9 ACHE

2.60e-0421262CID000189752
Drugsuberyldicholine

CHRNA9 ACHE

2.86e-0422262CID000123989
DrugAZFd

KDM5D KDM5C

3.13e-0423262CID000196489
DrugABT-418

CHRNA9 ACHE

3.13e-0423262CID000119380
Drugintruder

CHRNA9 ACHE

3.41e-0424262CID000213021
Drugisoamyl acetate

ACHE KCNH1

3.70e-0425262CID000031276
DrugPrBCM

CHRNA9 ACHE

3.70e-0425262CID000037396
Drugpempidine

CHRNA9 ACHE

3.70e-0425262CID000006603
DrugBungarotoxins

CHRNA9 ACHE

3.70e-0425262ctd:D002038
DrugAC1O3R20

ACHE KDM5C

4.65e-0428262CID006335051
Drugechothiophate

CHRNA9 ACHE

4.65e-0428262CID000010547
Drugpentolinium

CHRNA9 ACHE

4.65e-0428262CID000005849
Drugbifemelane

CHRNA9 ACHE

5.00e-0429262CID000002377
Druglinalool

ACHE KCNH1

5.00e-0429262CID000006549
DrugAC1L1JK6

CHRNA9 ACHE

5.71e-0431262CID000005077
Drugacetophenone

KDM5D KCNH1

6.09e-0432262CID000007410
Drugdecamethonium

CHRNA9 ACHE

6.48e-0433262CID000002968
Drugmethamidophos

CHRNA9 ACHE

6.48e-0433262CID000004096
DrugGTS-21

CHRNA9 ACHE

6.88e-0434262CID005310985
Druggallamine

CHRNA9 ACHE

7.29e-0435262CID000003450
Drugatracurium

CHRNA9 ACHE

7.29e-0435262CID000047319
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT_HG-U133A

TM9SF2 SLC9A6 KDM5C

7.86e-041602636133_DN
DrugHHSiD

CHRNA9 ACHE

8.15e-0437262CID000003602
DrugNSC-293162

CHRNA9 ACHE

8.60e-0438262CID000004675
Drugepps

ACHE KCNH1

9.52e-0440262CID000085255
Drugmethylatropine

CHRNA9 ACHE

9.52e-0440262CID000005860
DrugN-methylscopolamine

CHRNA9 ACHE

1.05e-0342262CID000004120
Druggallamin

CHRNA9 ACHE

1.10e-0343262CID000067425
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

ELOVL4 TMEM45A SLC9A6

1.11e-031802632639_UP
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5B KDM5D KDM5A KDM5C

4.73e-134264DOID:0060809 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5B KDM5D KDM5A KDM5C

8.55e-1016264DOID:0050888 (implicated_via_orthology)
Diseaseintellectual disability (implicated_via_orthology)

KDM5B KDM5D KDM5A KDM5C

5.52e-0775264DOID:1059 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5B KDM5D KDM5A KDM5C

9.26e-06152264DOID:0060041 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

KDM5B KDM5D KDM5A KDM5C

2.47e-05195264DOID:1574 (implicated_via_orthology)
DiseasePapillary Renal Cell Carcinoma

LRP1B ACHE KDM5C

1.93e-04128263C1306837
DiseaseRenal Cell Carcinoma

LRP1B ACHE KDM5C

1.93e-04128263C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

LRP1B ACHE KDM5C

1.93e-04128263C1266043
DiseaseChromophobe Renal Cell Carcinoma

LRP1B ACHE KDM5C

1.93e-04128263C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

LRP1B ACHE KDM5C

1.93e-04128263C1266044
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

LRP1B ACHE KDM5C

2.95e-04148263C0279702
DiseaseHuntington's disease (is_marker_for)

ACHE KDM5C

1.00e-0353262DOID:12858 (is_marker_for)
Diseaseadverse effect, response to xenobiotic stimulus

LRP1B ELOVL2

1.24e-0359262EFO_0009658, GO_0009410
DiseaseAmphetamine Abuse

CUBN ACHE

1.99e-0375262C0236807
DiseaseAmphetamine Addiction

CUBN ACHE

1.99e-0375262C0236804
DiseaseAmphetamine-Related Disorders

CUBN ACHE

1.99e-0375262C0236733
Diseasehepatocellular carcinoma (is_marker_for)

LRP1B KCNH1 KDM5C

2.30e-03301263DOID:684 (is_marker_for)
Diseaseinformation processing speed

LRP1B ATRNL1

2.55e-0385262EFO_0004363

Protein segments in the cluster

PeptideGeneStartEntry
WSSYMVHWKNQFDHY

ACHE

591

P22303
MNWSHSCISFCWIYF

CHRNA9

1

Q9UGM1
YWNAQRHPSWMAAYH

DDX20

796

Q9UHI6
YWWHQSTVYVMQYRH

PAQR3

286

Q6TCH7
YMGFTLYHVIWHWEL

GJC3

91

Q8NFK1
MHWFSYYTTHWTSLR

LRP1B

3991

Q9NZR2
SIQMWHYFCWSLHYD

KIAA0825

631

Q8IV33
HYFCWSLHYDLWTIL

KIAA0825

636

Q8IV33
YARYWQHYHQAMAWM

GEMIN8

21

Q9NWZ8
FLHVYHHCTMFTLWW

ELOVL4

156

Q9GZR5
FCWHIEDHWSYSINY

KDM5D

501

Q9BY66
HWMACIWYSIGDYEI

KCNH1

391

O95259
FCWHIEDHWSYSINY

KDM5B

496

Q9UGL1
CWHIEDHWSYSINYL

KDM5A

481

P29375
YHSSECYWWLKSSHG

CUBN

1186

O60494
HVYHHASMFNIWWCV

ELOVL2

146

Q9NXB9
LAYYHQEWTVFNSWC

CLCN5

546

P51795
SAHGYSWELWCMYIS

GALNT17

291

Q6IS24
NHFATECSWDHMYVY

ATRNL1

136

Q5VV63
SAWLFRMWYNFDHNY

SLC9A6

531

Q92581
DSDMLACHNYWHWAL

TTC38

246

Q5R3I4
LCYFHLCAEDYHWQW

TM9SF2

576

Q99805
LQAHWFTCELLWYMH

ZSWIM3

366

Q96MP5
MCHQTWSHSYMFWYR

TRBV10-2

41

A0A0K0K1G8
WSHSYMFWYRQDLGH

TRBV10-2

46

A0A0K0K1G8
QIYCMTHDEGFYWWD

WDR89

231

Q96FK6
HWNQLLGWHHFTMYF

TMEM45A

86

Q9NWC5
FHHMCYWELMWCFTY

TTC39A

351

Q5SRH9
FCWHIEDHWSYSINY

KDM5C

511

P41229