Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellular sodium-activated potassium channel activity	KCNT2 KCNT1	3.34e-06	2	37	2	GO:0005228
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA10 EPHA4	3.46e-04	15	37	2	GO:0005005
GeneOntologyMolecularFunction	ephrin receptor activity	EPHA10 EPHA4	5.60e-04	19	37	2	GO:0005003
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNT2 KCNT1	1.14e-03	27	37	2	GO:0015271
GeneOntologyMolecularFunction	DNA-directed 5'-3' RNA polymerase activity	POLR1A POLR2A	1.41e-03	30	37	2	GO:0003899
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNT2 KCNT1	1.50e-03	31	37	2	GO:0022839
GeneOntologyMolecularFunction	5'-3' RNA polymerase activity	POLR1A POLR2A	1.60e-03	32	37	2	GO:0034062
GeneOntologyMolecularFunction	RNA polymerase activity	POLR1A POLR2A	1.60e-03	32	37	2	GO:0097747
GeneOntologyCellularComponent	transferase complex	CUL4B CUL4A PHF1 UBR1 FBXW8 ZSWIM6 RB1CC1 POLR1A PIK3C2G POLR2A	3.50e-06	963	36	10	GO:1990234
GeneOntologyCellularComponent	intracellular protein-containing complex	CUL4B CUL4A UBR1 FBXW8 ZSWIM6 POLR1A CNOT10 POLR2A	2.01e-04	972	36	8	GO:0140535
GeneOntologyCellularComponent	Cul4A-RING E3 ubiquitin ligase complex	CUL4B CUL4A	2.59e-04	14	36	2	GO:0031464
GeneOntologyCellularComponent	ubiquitin ligase complex	CUL4B CUL4A UBR1 FBXW8 ZSWIM6	3.23e-04	352	36	5	GO:0000151
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	CUL4B CUL4A FBXW8 ZSWIM6	4.70e-04	212	36	4	GO:0031461
Domain	Envoplakin	EVPL EVPLL	3.82e-06	2	37	2	IPR030460
Domain	RNA_pol_Rpb1_2	POLR1A POLR2A	1.14e-05	3	37	2	PF00623
Domain	RNA_pol_N	POLR1A POLR2A	1.14e-05	3	37	2	IPR006592
Domain	RPOLA_N	POLR1A POLR2A	1.14e-05	3	37	2	SM00663
Domain	RNA_pol_Rpb1_4	POLR1A POLR2A	1.14e-05	3	37	2	IPR007083
Domain	RNA_pol_Rpb1_5	POLR1A POLR2A	1.14e-05	3	37	2	IPR007081
Domain	RNA_pol_Rpb1_1	POLR1A POLR2A	1.14e-05	3	37	2	IPR007080
Domain	RNA_pol_Rpb1_1	POLR1A POLR2A	1.14e-05	3	37	2	PF04997
Domain	RNA_pol_Rpb1_5	POLR1A POLR2A	1.14e-05	3	37	2	PF04998
Domain	RNA_pol_Rpb1_3	POLR1A POLR2A	1.14e-05	3	37	2	IPR007066
Domain	RNA_pol_Rpb1_3	POLR1A POLR2A	1.14e-05	3	37	2	PF04983
Domain	RNA_pol_Rpb1_4	POLR1A POLR2A	1.14e-05	3	37	2	PF05000
Domain	RNA_pol_asu	POLR1A POLR2A	1.14e-05	3	37	2	IPR000722
Domain	K_chnl_Ca-activ_BK_asu	KCNT2 KCNT1	2.29e-05	4	37	2	IPR003929
Domain	BK_channel_a	KCNT2 KCNT1	2.29e-05	4	37	2	PF03493
Domain	Cullin_CS	CUL4B CUL4A	7.97e-05	7	37	2	IPR016157
Domain	CULLIN	CUL4B CUL4A	7.97e-05	7	37	2	SM00182
Domain	Cullin_Nedd8	CUL4B CUL4A	1.06e-04	8	37	2	PF10557
Domain	Cullin_Nedd8	CUL4B CUL4A	1.06e-04	8	37	2	SM00884
Domain	Cullin_neddylation_domain	CUL4B CUL4A	1.06e-04	8	37	2	IPR019559
Domain	Cullin_homology	CUL4B CUL4A	1.36e-04	9	37	2	IPR016158
Domain	Cullin_N	CUL4B CUL4A	1.70e-04	10	37	2	IPR001373
Domain	Cullin	CUL4B CUL4A	1.70e-04	10	37	2	PF00888
Domain	CULLIN_2	CUL4B CUL4A	1.70e-04	10	37	2	PS50069
Domain	CULLIN_1	CUL4B CUL4A	1.70e-04	10	37	2	PS01256
Domain	Cullin_repeat-like_dom	CUL4B CUL4A	2.49e-04	12	37	2	IPR016159
Domain	RECEPTOR_TYR_KIN_V_2	EPHA10 EPHA4	3.42e-04	14	37	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA10 EPHA4	3.42e-04	14	37	2	PS00790
Domain	EphA2_TM	EPHA10 EPHA4	3.42e-04	14	37	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA10 EPHA4	3.42e-04	14	37	2	IPR016257
Domain	Eph_TM	EPHA10 EPHA4	3.42e-04	14	37	2	IPR027936
Domain	Ephrin_rcpt_lig-bd_dom	EPHA10 EPHA4	3.42e-04	14	37	2	IPR001090
Domain	Tyr_kinase_rcpt_V_CS	EPHA10 EPHA4	3.42e-04	14	37	2	IPR001426
Domain	EPH_LBD	EPHA10 EPHA4	3.42e-04	14	37	2	PS51550
Domain	EPH_lbd	EPHA10 EPHA4	3.42e-04	14	37	2	SM00615
Domain	Ephrin_lbd	EPHA10 EPHA4	3.42e-04	14	37	2	PF01404
Domain	FN3	KIAA0319 LEPR EPHA10 EPHA4	4.77e-04	185	37	4	SM00060
Domain	FN3_dom	KIAA0319 LEPR EPHA10 EPHA4	7.53e-04	209	37	4	IPR003961
Domain	K_chnl_dom	KCNT2 KCNT1	7.83e-04	21	37	2	IPR013099
Domain	Ion_trans_2	KCNT2 KCNT1	7.83e-04	21	37	2	PF07885
Domain	Ephrin_rec_like	EPHA10 EPHA4	1.11e-03	25	37	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA10 EPHA4	1.11e-03	25	37	2	IPR011641
Domain	WHTH_DNA-bd_dom	CUL4B CUL4A UBR1 VPS36	1.30e-03	242	37	4	IPR011991
Domain	Spectrin/alpha-actinin	EVPL EVPLL	1.82e-03	32	37	2	IPR018159
Domain	SPEC	EVPL EVPLL	1.82e-03	32	37	2	SM00150
Domain	Quinoprotein_ADH-like_supfam	FBXW8 AHCTF1	4.94e-03	53	37	2	IPR011047
Domain	FN3	LEPR EPHA10 EPHA4	7.09e-03	199	37	3	PS50853
Domain	-	CUL4B CUL4A VPS36	9.10e-03	218	37	3	1.10.10.10
Domain	-	EPHA10 EPHA4	9.19e-03	73	37	2	2.60.120.260
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	CUL4B CUL4A POLR2A	1.53e-04	51	29	3	MM15315
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	CUL4B CUL4A POLR2A	1.53e-04	51	29	3	M27599
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M	CUL4B CUL4A	2.22e-04	11	29	2	M47573
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A POLR2A	2.86e-04	63	29	3	MM15317
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A POLR2A	2.86e-04	63	29	3	M27601
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A POLR2A	4.78e-04	75	29	3	MM15316
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A POLR2A	4.97e-04	76	29	3	M27600
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	EPHA10 EPHA4	6.13e-04	18	29	2	MM15023
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A POLR2A	1.38e-03	108	29	3	MM15304
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A POLR2A	1.38e-03	108	29	3	M7927
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	EPHA10 EPHA4	1.60e-03	29	29	2	M27309
Pathway	KEGG_RNA_POLYMERASE	POLR1A POLR2A	1.60e-03	29	29	2	M1724
Pathway	REACTOME_RECOGNITION_OF_DNA_DAMAGE_BY_PCNA_CONTAINING_REPLICATION_COMPLEX	CUL4B CUL4A	1.72e-03	30	29	2	M26898
Pathway	REACTOME_RECOGNITION_OF_DNA_DAMAGE_BY_PCNA_CONTAINING_REPLICATION_COMPLEX	CUL4B CUL4A	1.72e-03	30	29	2	MM14476
Pathway	KEGG_MEDICUS_REFERENCE_TRANSCRIPTION_COUPLED_NER	CUL4A POLR2A	1.83e-03	31	29	2	M47825
Pubmed	The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.	CUL4B CUL4A POLR2A	1.01e-07	9	38	3	34233190
Pubmed	Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.	KCNT2 KCNT1	1.16e-06	2	38	2	25347289
Pubmed	Molecular mechanisms of Slo2 K+ channel closure.	KCNT2 KCNT1	1.16e-06	2	38	2	27682982
Pubmed	Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.	CUL4B CUL4A	1.16e-06	2	38	2	20064923
Pubmed	Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.	CUL4B CUL4A	1.16e-06	2	38	2	27974468
Pubmed	Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.	KCNT2 KCNT1	1.16e-06	2	38	2	17344399
Pubmed	Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.	KCNT2 KCNT1	1.16e-06	2	38	2	26587966
Pubmed	Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.	EPHA10 EPHA4	1.16e-06	2	38	2	23352741
Pubmed	Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.	KCNT2 KCNT1	1.16e-06	2	38	2	30796290
Pubmed	Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.	KCNT2 KCNT1	1.16e-06	2	38	2	26845140
Pubmed	CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.	CUL4B CUL4A FBXW8	1.58e-06	21	38	3	12481031
Pubmed	CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.	CUL4B CUL4A	3.48e-06	3	38	2	34119472
Pubmed	Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.	KCNT2 KCNT1	3.48e-06	3	38	2	26559620
Pubmed	CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.	CUL4B CUL4A	3.48e-06	3	38	2	32587774
Pubmed	Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.	CUL4B CUL4A	3.48e-06	3	38	2	17954973
Pubmed	RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells.	POLR1A POLR2A	3.48e-06	3	38	2	27502483
Pubmed	E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.	CUL4B CUL4A	3.48e-06	3	38	2	24452595
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	CUL4B CUL4A PHF1 POLR2A	4.23e-06	99	38	4	34161765
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	CUL4B CUL4A POLR2A	5.30e-06	31	38	3	32355176
Pubmed	Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B.	CUL4B CUL4A	6.96e-06	4	38	2	30945295
Pubmed	Lack of pathogenic mutations in six patients with MMPSI.	KCNT1 SCN1A	6.96e-06	4	38	2	24315024
Pubmed	Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.	CUL4B CUL4A	6.96e-06	4	38	2	34420308
Pubmed	CRL4s: the CUL4-RING E3 ubiquitin ligases.	CUL4B CUL4A	6.96e-06	4	38	2	19818632
Pubmed	Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.	CUL4B CUL4A	6.96e-06	4	38	2	22453236
Pubmed	Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.	CUL4B CUL4A	6.96e-06	4	38	2	22262661
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CUL4B PHF1 RB1CC1 CRISPLD1 ZMYM4 AHCTF1	1.12e-05	469	38	6	27634302
Pubmed	CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.	CUL4B CUL4A	1.16e-05	5	38	2	32466489
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	CUL4B CUL4A	1.16e-05	5	38	2	24719410
Pubmed	The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.	CUL4B CUL4A	1.16e-05	5	38	2	22118460
Pubmed	Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.	CUL4B CUL4A	1.16e-05	5	38	2	25542213
Pubmed	Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.	CUL4B CUL4A	1.16e-05	5	38	2	27142104
Pubmed	Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.	CUL4B CUL4A	1.16e-05	5	38	2	26711351
Pubmed	Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.	CUL4B LEPR	1.16e-05	5	38	2	37224018
Pubmed	Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.	CUL4B CUL4A	1.16e-05	5	38	2	34171797
Pubmed	Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.	CUL4B CUL4A	1.16e-05	5	38	2	36056023
Pubmed	Selective degradation of splicing factor CAPERα by anticancer sulfonamides.	CUL4B CUL4A	1.16e-05	5	38	2	28437394
Pubmed	The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.	CUL4B CUL4A	1.16e-05	5	38	2	26021757
Pubmed	Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.	CUL4B CUL4A	1.16e-05	5	38	2	30923324
Pubmed	Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.	CUL4B CUL4A	1.74e-05	6	38	2	14578910
Pubmed	cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.	CUL4B CUL4A	1.74e-05	6	38	2	8681378
Pubmed	PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.	CUL4B CUL4A	1.74e-05	6	38	2	16407252
Pubmed	Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.	CUL4B CUL4A	1.74e-05	6	38	2	22606329
Pubmed	The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.	CUL4B CUL4A	1.74e-05	6	38	2	18593899
Pubmed	CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.	CUL4B CUL4A	1.74e-05	6	38	2	25795299
Pubmed	MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.	CUL4B CUL4A	1.74e-05	6	38	2	34251884
Pubmed	CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.	CUL4B CUL4A	1.74e-05	6	38	2	20932471
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	CUL4B CUL4A FBXW8	2.01e-05	48	38	3	33504946
Pubmed	Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation.	CUL4B CUL4A	2.43e-05	7	38	2	30898011
Pubmed	SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.	CUL4B CUL4A	2.43e-05	7	38	2	35320725
Pubmed	Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.	CUL4B CUL4A	2.43e-05	7	38	2	27294876
Pubmed	Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.	CUL4B CUL4A	2.43e-05	7	38	2	37024504
Pubmed	Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).	CUL4B CUL4A	2.43e-05	7	38	2	21228219
Pubmed	Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.	CUL4B CUL4A	2.43e-05	7	38	2	23297343
Pubmed	Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.	CUL4B CUL4A	2.43e-05	7	38	2	23555860
Pubmed	Structural basis of human transcription-DNA repair coupling.	CUL4A POLR2A	2.43e-05	7	38	2	34526721
Pubmed	The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.	SSPN POLR2A	2.43e-05	7	38	2	17234882
Pubmed	Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligases to inhibit colorectal cancer cell growth.	CUL4B CUL4A	2.43e-05	7	38	2	32140073
Pubmed	mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.	CUL4B CUL4A	3.24e-05	8	38	2	18235224
Pubmed	The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.	CUL4B CUL4A	3.24e-05	8	38	2	31614064
Pubmed	Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.	CUL4B CUL4A	3.24e-05	8	38	2	27580824
Pubmed	Covalent modification of all members of human cullin family proteins by NEDD8.	CUL4B CUL4A	3.24e-05	8	38	2	10597293
Pubmed	International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.	KCNT2 KCNT1	3.24e-05	8	38	2	16382103
Pubmed	CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.	CUL4B CUL4A	3.24e-05	8	38	2	28178526
Pubmed	CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.	CUL4B CUL4A	3.24e-05	8	38	2	12504026
Pubmed	The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.	CUL4B CUL4A	3.24e-05	8	38	2	30018425
Pubmed	PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.	CUL4B CUL4A	4.16e-05	9	38	2	18794347
Pubmed	STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.	CUL4B CUL4A	4.16e-05	9	38	2	34518307
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	CUL4A UBR1	4.16e-05	9	38	2	17855541
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	CUL4B CUL4A UBR1	4.35e-05	62	38	3	18775313
Pubmed	Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.	CUL4B CUL4A	5.20e-05	10	38	2	16678110
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA10 EPHA4	5.20e-05	10	38	2	25073978
Pubmed	IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.	CUL4B CUL4A	5.20e-05	10	38	2	33911083
Pubmed	L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.	CUL4B CUL4A	5.20e-05	10	38	2	16861890
Pubmed	Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis.	CUL4B CUL4A	5.20e-05	10	38	2	34685710
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA10 EPHA4	5.20e-05	10	38	2	16547242
Pubmed	The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.	CUL4B CUL4A	6.35e-05	11	38	2	33854239
Pubmed	TIP120A associates with cullins and modulates ubiquitin ligase activity.	CUL4B CUL4A	6.35e-05	11	38	2	12609982
Pubmed	Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis.	CUL4B CUL4A	6.35e-05	11	38	2	37390815
Pubmed	SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.	CUL4B CUL4A	7.62e-05	12	38	2	18826954
Pubmed	SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes.	CUL4B CUL4A	7.62e-05	12	38	2	28886238
Pubmed	NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.	CUL4B CUL4A	7.62e-05	12	38	2	22466964
Pubmed	The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.	CUL4B CUL4A	7.62e-05	12	38	2	19617556
Pubmed	KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.	CUL4B CUL4A	7.62e-05	12	38	2	33173725
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	CUL4A UBR1	7.62e-05	12	38	2	17360488
Pubmed	Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.	CUL4A POLR2A	9.00e-05	13	38	2	19037258
Pubmed	L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.	CUL4B CUL4A	9.00e-05	13	38	2	16861906
Pubmed	Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.	CUL4B CUL4A	9.00e-05	13	38	2	23201271
Pubmed	FACT facilitates chromatin transcription by RNA polymerases I and III.	POLR1A POLR2A	9.00e-05	13	38	2	19214185
Pubmed	A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.	POLR1A POLR2A	9.00e-05	13	38	2	20541997
Pubmed	ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.	CUL4B CUL4A	1.05e-04	14	38	2	10230407
Pubmed	Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.	CUL4B CUL4A	1.05e-04	14	38	2	22474075
Pubmed	CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.	CUL4B CUL4A	1.05e-04	14	38	2	22032989
Pubmed	Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.	CUL4B CUL4A	1.05e-04	14	38	2	26471094
Pubmed	Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2.	CUL4B CUL4A	1.05e-04	14	38	2	30779731
Pubmed	Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.	SLC4A3 EPHA4	1.05e-04	14	38	2	24811271
Pubmed	Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.	CUL4B CUL4A	1.21e-04	15	38	2	21628527
Pubmed	Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.	CUL4B CUL4A	1.21e-04	15	38	2	37091236
Pubmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	CUL4B CUL4A	1.21e-04	15	38	2	29691401
Pubmed	CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1.	CUL4B CUL4A	1.21e-04	15	38	2	35487060
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	CUL4B CUL4A UBR1	1.32e-04	90	38	3	35671810
Interaction	SMC1A interactions	CUL4B CUL4A PHF1 LHX2 RB1CC1 POLR1A POLR2A	9.45e-06	418	37	7	int:SMC1A
Cytoband	Ensembl 112 genes in cytogenetic band chr12p12	SSPN PIK3C2G	3.98e-03	113	38	2	chr12p12
GeneFamily	Potassium sodium-activated channel subfamily T	KCNT2 KCNT1	2.66e-06	2	30	2	856
GeneFamily	EF-hand domain containing\|Plakins	EVPL EVPLL	7.41e-05	8	30	2	939
GeneFamily	Cullins	CUL4B CUL4A	7.41e-05	8	30	2	1032
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA10 EPHA4	2.39e-04	14	30	2	1095
GeneFamily	RNA polymerase subunits	POLR1A POLR2A	1.05e-03	29	30	2	726
GeneFamily	Sterile alpha motif domain containing	EPHA10 EPHA4	9.33e-03	88	30	2	760
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8\|TCGA-Thymus / Sample_Type by Project: Shred V9	PDE5A KCNT2 CRISPLD1 LEPR SCN1A	1.83e-07	151	38	5	5906562efd36fbcb91f96e0a0d3a8fe999ba1e79
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	UBR1 LEPR	9.90e-04	36	38	2	DOID:0080208 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	KCNT2 KCNT1 SCN1A	1.21e-03	163	38	3	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTWRMHLFTCIQLGC	SLC4A3	1151	P48751
CWHSLFKIQNRLAAM	DNHD1	2001	Q96M86
VCTCLVALMQKNWRH	CAPN11	441	Q9UMQ6
VHKFVAMWRKILQNC	PPP2R3B	196	Q9Y5P8
QLLEFMHIWKVSRQC	PIK3C2G	391	O75747
NNLHVRLKWCCFVML	RB1CC1	446	Q8TDY2
RLKWCCFVMLHADQD	RB1CC1	451	Q8TDY2
CLICCAVLFVMWKNV	OTOP3	301	Q7RTS5
ICNNKILWLICSEFM	LIPN	246	Q5VXI9
LFFLLHRWCCNKKNA	KIR2DL3	261	P43628
LNCWLAKHALENMIN	KCNT1	221	Q5JUK3
IALHQLMLDCWQKER	EPHA4	851	P54764
CWKLIFQECRAKEHM	FBXW8	176	Q8N3Y1
QNFQMKHEVLCRWIL	PDE5A	586	O76074
LKMEWQNFLNLCICQ	EVPLL	266	A8MZ36
LKMEWQNFLNLCICQ	EVPL	311	Q92817
MICQKFCVVLLHWEF	LEPR	1	P48357
LLAVDKQWHMRCLKC	LHX2	66	P50458
VFLNCWLAKHALENM	KCNT2	166	Q6UVM3
CPNLLHRLMLDCWQK	EPHA10	871	Q5JZY3
CAINLCHNMNIWGQI	CRISPLD1	181	Q9H336
NTCWQDHCRQMIMIR	CUL4A	136	Q13619
QQHLFWVTMLGQCLC	FLVCR1	196	Q9Y5Y0
NRCMVEAWNFLRQHC	AHCTF1	886	Q8WYP5
LKKIDRCWQNHCRQM	CUL4B	286	Q13620
MLQCRSCLQWFHEAC	PHF1	201	O43189
LIALFWKAHMNAKRC	POLR1A	191	O95602
MAAHQNLILKIFCLC	TEX48	1	A0A1B0GUV7
GLVCLLACFVMWKHR	SSPN	206	Q14714
CKIASDCQLPRWHMN	SCN1A	921	P35498
LRCMFWNNLGCIHFA	CNOT10	291	Q9H9A5
RLIWRDQKNHECCMA	VPS36	46	Q86VN1
CNLLRMIWNAQKIFH	POLR2A	981	P24928
KNCIQLMKLLGWTHC	TPP2	1216	P29144
QLKNILLMFQEWCAC	UBR1	541	Q8IWV7
WLHLDLIKEMRQFCQ	SRM	211	P19623
ALWMCIVLNPHCKLE	ZSWIM6	446	Q9HCJ5
WRGEMKHFCNLLCIL	ZMYM4	831	Q5VZL5
LTKRCICSHLWMENL	KIAA0319	926	Q5VV43