Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	TPO KDM4C SQLE JMJD4 CYP4F22 PLOD2	6.60e-05	194	71	6	GO:0016705
GeneOntologyMolecularFunction	histone H2AX kinase activity	VRK1 PRKDC	1.24e-04	5	71	2	GO:0141003
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor activity	FLT1 KDR	2.59e-04	7	71	2	GO:0005021
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM4C JMJD4 PLOD2	1.61e-03	65	71	3	GO:0016706
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	FLT1 KDR FGFR2	1.61e-03	65	71	3	GO:0004714
GeneOntologyMolecularFunction	acid-amino acid ligase activity	TTLL3 TTLL1	3.01e-03	23	71	2	GO:0016881
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	FLT1 KDR FGFR2	3.45e-03	85	71	3	GO:0019199
MousePheno	impaired cranial neural crest cell differentiation	KDR MED23	1.63e-05	2	57	2	MP:0012756
Domain	IG	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	1.73e-04	421	70	8	SM00409
Domain	Ig_sub	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	1.73e-04	421	70	8	IPR003599
Domain	IGc2	HEPACAM FLT1 LRRN3 KDR FGFR2 LILRB5	2.49e-04	235	70	6	SM00408
Domain	Ig_sub2	HEPACAM FLT1 LRRN3 KDR FGFR2 LILRB5	2.49e-04	235	70	6	IPR003598
Domain	Tyr_kinase_rcpt_3_CS	FLT1 KDR	3.82e-04	8	70	2	IPR001824
Domain	RECEPTOR_TYR_KIN_III	FLT1 KDR	3.82e-04	8	70	2	PS00240
Domain	IG_LIKE	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	4.87e-04	491	70	8	PS50835
Domain	Ig-like_dom	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	5.71e-04	503	70	8	IPR007110
Domain	Ig_I-set	HEPACAM FLT1 LRRN3 KDR FGFR2	7.32e-04	190	70	5	IPR013098
Domain	I-set	HEPACAM FLT1 LRRN3 KDR FGFR2	7.32e-04	190	70	5	PF07679
Domain	FAD-dep_OxRdtase	DMGDH SQLE	8.92e-04	12	70	2	IPR006076
Domain	DAO	DMGDH SQLE	8.92e-04	12	70	2	PF01266
Domain	Ig_V-set	HEPACAM FLT1 MPZL1 KDR VSTM2B	9.02e-04	199	70	5	IPR013106
Domain	Quinoprotein_ADH-like_supfam	WDR7 EML4 GEMIN5	1.03e-03	53	70	3	IPR011047
Domain	TTL	TTLL3 TTLL1	1.05e-03	13	70	2	PS51221
Domain	TTL/TTLL_fam	TTLL3 TTLL1	1.05e-03	13	70	2	IPR004344
Domain	TTL	TTLL3 TTLL1	1.05e-03	13	70	2	PF03133
Domain	-	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	3.28e-03	663	70	8	2.60.40.10
Domain	Pentatricopeptide_repeat	DENND4A PRKDC	3.33e-03	23	70	2	IPR002885
Domain	PDEase_catalytic_dom	TBC1D10B SAMHD1	3.33e-03	23	70	2	IPR002073
Domain	WD40_repeat_CS	PWP1 WDR7 EML4 GEMIN5	3.35e-03	164	70	4	IPR019775
Domain	JmjC	KDM4C JMJD4	3.62e-03	24	70	2	PF02373
Domain	TyrKc	FLT1 KDR FGFR2	4.41e-03	88	70	3	SM00219
Domain	Tyr_kinase_cat_dom	FLT1 KDR FGFR2	4.41e-03	88	70	3	IPR020635
Domain	Ig-like_fold	HEPACAM FLT1 LRRN3 MPZL1 KDR VSTM2B FGFR2 LILRB5	4.79e-03	706	70	8	IPR013783
Domain	V-set	HEPACAM MPZL1 KDR VSTM2B	5.04e-03	184	70	4	PF07686
Domain	FYVE	FGD4 ZFYVE1	5.27e-03	29	70	2	PF01363
Domain	FYVE	FGD4 ZFYVE1	5.27e-03	29	70	2	SM00064
Domain	SAM_DOMAIN	ARAP3 SAMHD1 GAREM1	5.46e-03	95	70	3	PS50105
Domain	PROTEIN_KINASE_TYR	FLT1 KDR FGFR2	5.78e-03	97	70	3	PS00109
Domain	SAM	ARAP3 SAMHD1 GAREM1	5.78e-03	97	70	3	IPR001660
Domain	Tyr_kinase_AS	FLT1 KDR FGFR2	5.78e-03	97	70	3	IPR008266
Pathway	PID_AR_PATHWAY	KDM4C SVIL PRKDC NCOA4	9.18e-05	61	55	4	M58
Pathway	WP_ANGIOGENESIS	FLT1 KDR FGFR2	1.07e-04	24	55	3	M39556
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	FLT1 KDR FGFR2	1.22e-04	25	55	3	M47934
Pathway	PID_HIF2PATHWAY	FLT1 KDR MMP14	3.09e-04	34	55	3	M44
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	FLT1 KDR	4.12e-04	8	55	2	M710
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	FLT1 KDR	4.12e-04	8	55	2	MM14753
Pubmed	Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells.	FLT1 KDR FGFR2	3.40e-08	4	72	3	11693202
Pubmed	The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients.	FLT1 KDR FGFR2	7.08e-07	9	72	3	23620752
Pubmed	Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.	FLT1 KDR FGFR2	1.39e-06	11	72	3	17981115
Pubmed	Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.	FLT1 KDR	4.23e-06	2	72	2	8356051
Pubmed	Hypoxia-induced reduction of sVEGFR-2 levels in human colonic microvascular endothelial cells in vitro: Comparative study with HUVEC.	FLT1 KDR	4.23e-06	2	72	2	19082506
Pubmed	VEGFR1 and VEGFR2 immunohistochemical expression in oral squamous cell carcinoma: a morphometric study.	FLT1 KDR	4.23e-06	2	72	2	22203933
Pubmed	Vascular endothelial growth factor and its receptors in normal human testicular tissue.	FLT1 KDR	4.23e-06	2	72	2	9256359
Pubmed	Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus.	FLT1 KDR	4.23e-06	2	72	2	19200976
Pubmed	Production of VEGF receptor 1 and 2 mRNA and protein during endochondral bone repair is differential and healing phase specific.	FLT1 KDR	4.23e-06	2	72	2	20947709
Pubmed	Absence of mutations in the activation loop and juxtamembrane domains of VEGFR-1 and VEGFR-2 gene in chronic myelomonocytic leukemia (CMML).	FLT1 KDR	4.23e-06	2	72	2	22153185
Pubmed	Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions.	FLT1 KDR	4.23e-06	2	72	2	18975312
Pubmed	Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice.	FLT1 KDR	4.23e-06	2	72	2	15852018
Pubmed	VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density.	FLT1 KDR	4.23e-06	2	72	2	25895461
Pubmed	Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment.	FLT1 KDR	4.23e-06	2	72	2	20484670
Pubmed	MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.	CIITA PRKDC	4.23e-06	2	72	2	16081800
Pubmed	VEGFR1 and VEGFR2 in Alzheimer's Disease.	FLT1 KDR	4.23e-06	2	72	2	29226875
Pubmed	Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.	TPO SH2B3	4.23e-06	2	72	2	28067429
Pubmed	The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.	FLT1 KDR	4.23e-06	2	72	2	18504303
Pubmed	Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes.	FLT1 KDR	4.23e-06	2	72	2	20158393
Pubmed	Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye.	FLT1 KDR	4.23e-06	2	72	2	21731737
Pubmed	Expression of VEGF receptors on endothelial cells in mouse skeletal muscle.	FLT1 KDR	4.23e-06	2	72	2	22984559
Pubmed	Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma.	FLT1 KDR	4.23e-06	2	72	2	16786116
Pubmed	Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells.	FLT1 KDR	4.23e-06	2	72	2	8126087
Pubmed	Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.	FLT1 KDR	4.23e-06	2	72	2	32088190
Pubmed	Expression of vascular endothelial growth factor receptors during male germ cell differentiation in the mouse.	FLT1 KDR	4.23e-06	2	72	2	12773425
Pubmed	VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.	FLT1 KDR	4.23e-06	2	72	2	23977149
Pubmed	A cyclic peptide reproducing the α1 helix of VEGF-B binds to VEGFR-1 and VEGFR-2 and inhibits angiogenesis and tumor growth.	FLT1 KDR	4.23e-06	2	72	2	30700502
Pubmed	Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.	FLT1 KDR	4.23e-06	2	72	2	15611243
Pubmed	Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.	MUC16 MMP14	4.23e-06	2	72	2	25205731
Pubmed	Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury.	FGFR2 MMP14	4.23e-06	2	72	2	17557804
Pubmed	Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.	FLT1 KDR	4.23e-06	2	72	2	18433297
Pubmed	Inhibition of prostate cancer osteoblastic progression with VEGF121/rGel, a single agent targeting osteoblasts, osteoclasts, and tumor neovasculature.	FLT1 KDR	4.23e-06	2	72	2	21343372
Pubmed	Selected angiogenic cytokines in systemic lupus erythematosus patients.	FLT1 KDR	4.23e-06	2	72	2	19811263
Pubmed	Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice.	FLT1 KDR	4.23e-06	2	72	2	22426483
Pubmed	The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation.	FLT1 KDR	4.23e-06	2	72	2	15111299
Pubmed	VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.	FLT1 KDR	4.23e-06	2	72	2	18174461
Pubmed	Increased expression of KDR/Flk-1 (VEGFR-2) in murine model of ischemia-induced retinal neovascularization.	FLT1 KDR	4.23e-06	2	72	2	9828156
Pubmed	The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.	FLT1 KDR	4.23e-06	2	72	2	19955220
Pubmed	Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2.	FLT1 KDR	4.23e-06	2	72	2	17325350
Pubmed	Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis.	FLT1 KDR	4.23e-06	2	72	2	30401688
Pubmed	Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.	FLT1 KDR	4.23e-06	2	72	2	19265665
Pubmed	Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro.	FLT1 KDR	4.23e-06	2	72	2	11824379
Pubmed	VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia.	FLT1 KDR	4.23e-06	2	72	2	14996703
Pubmed	Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF.	FLT1 KDR	4.23e-06	2	72	2	17376891
Pubmed	Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades.	FLT1 KDR	4.23e-06	2	72	2	20103598
Pubmed	Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-terminus.	SVIL NEB	4.23e-06	2	72	2	18639526
Pubmed	Quantitative real-time reverse transcription PCR study of the expression of vascular endothelial growth factor (VEGF) splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) in non small cell lung cancer.	FLT1 KDR	4.23e-06	2	72	2	17599955
Pubmed	Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma.	FLT1 PRKDC	4.23e-06	2	72	2	28377452
Pubmed	Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.	FLT1 KDR	4.23e-06	2	72	2	16793887
Pubmed	The soluble VEGF receptor 1 and 2 expression in cerebral spinal fluid as an indicator for leukemia central nervous system metastasis.	FLT1 KDR	4.23e-06	2	72	2	23400753
Pubmed	Vascular endothelial growth factor and its soluble receptors VEGFR-1 and VEGFR-2 in the serum of patients with systemic lupus erythematosus.	FLT1 KDR	4.23e-06	2	72	2	14760936
Pubmed	DC electric stimulation upregulates angiogenic factors in endothelial cells through activation of VEGF receptors.	FLT1 KDR	4.23e-06	2	72	2	21524919
Pubmed	VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis.	FLT1 KDR	4.23e-06	2	72	2	23799140
Pubmed	Endothelial progenitor cells induce transplant arteriosclerosis via VEGFR-1/2 activity.	FLT1 KDR	4.23e-06	2	72	2	25437886
Pubmed	VEGFR2-mediated vascular dilation as a mechanism of VEGF-induced anemia and bone marrow cell mobilization.	FLT1 KDR	4.23e-06	2	72	2	25310988
Pubmed	Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.	FLT1 KDR	4.23e-06	2	72	2	9295307
Pubmed	Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta.	FLT1 KDR	4.23e-06	2	72	2	14668430
Pubmed	Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms.	FLT1 KDR	4.23e-06	2	72	2	15592523
Pubmed	Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.	FLT1 KDR	4.23e-06	2	72	2	23376830
Pubmed	Identification of functional VEGF receptors on human platelets.	FLT1 KDR	4.23e-06	2	72	2	11852061
Pubmed	Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.	FLT1 KDR	4.23e-06	2	72	2	9973224
Pubmed	Expression of vascular endothelial growth factor receptor-1/-2 and nitric oxide in unruptured intracranial aneurysms.	FLT1 KDR	4.23e-06	2	72	2	20635108
Pubmed	Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.	FLT1 KDR	4.23e-06	2	72	2	21168388
Pubmed	Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction.	FLT1 KDR	4.23e-06	2	72	2	29158084
Pubmed	Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung.	FLT1 KDR	4.23e-06	2	72	2	20921519
Pubmed	Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors.	FLT1 KDR	4.23e-06	2	72	2	12426207
Pubmed	Randomized Phase II Study of Ramucirumab or Icrucumab in Combination with Capecitabine in Patients with Previously Treated Locally Advanced or Metastatic Breast Cancer.	FLT1 KDR	4.23e-06	2	72	2	28220020
Pubmed	Comparative study of human colonic tumor-derived endothelial cells (HCTEC) and normal colonic microvascular endothelial cells (HCMEC): Hypoxia-induced sVEGFR-1 and sVEGFR-2 levels.	FLT1 KDR	4.23e-06	2	72	2	19287991
Pubmed	Immunohistochemical expression of vascular endothelial growth factor A (VEGF), and its receptors (VEGFR1, 2) in normal and pathologic conditions of the human thymus.	FLT1 KDR	4.23e-06	2	72	2	18356031
Pubmed	Prognostic significance of VEGF receptors expression on the tumor cells in skull base chordoma.	FLT1 KDR	4.23e-06	2	72	2	31240525
Pubmed	The Prognostic Value of the Combination of Low VEGFR-1 and High VEGFR-2 Expression in Endothelial Cells of Colorectal Cancer.	FLT1 KDR	4.23e-06	2	72	2	30423986
Pubmed	The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis.	FLT1 KDR	4.23e-06	2	72	2	22828632
Pubmed	Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2.	FLT1 KDR	4.23e-06	2	72	2	30929546
Pubmed	Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia.	FLT1 KDR	4.23e-06	2	72	2	29351188
Pubmed	Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.	FLT1 KDR	4.23e-06	2	72	2	10865839
Pubmed	Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems?	FLT1 KDR	4.23e-06	2	72	2	12814952
Pubmed	In vivo regulation of mRNA expression of vascular endothelial growth factor receptors (KDR and flt-1) in the human oviduct.	FLT1 KDR	4.23e-06	2	72	2	14967383
Pubmed	Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.	FLT1 KDR	4.23e-06	2	72	2	19333381
Pubmed	Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis.	FLT1 KDR	4.23e-06	2	72	2	34774518
Pubmed	Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta.	FLT1 KDR	4.23e-06	2	72	2	24260556
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PWP1 WWC2 TBC1D10B EML4 SVIL FIP1L1 GEMIN5 PRKDC NKAP PLEC	4.35e-06	774	72	10	15302935
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	GPLD1 DENND4A SH2B3 SMG5 NCOA4	4.43e-06	116	72	5	20139978
Pubmed	Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.	DMGDH FLT1 MPZL1 GBGT1 SAMHD1	4.62e-06	117	72	5	12107410
Pubmed	A molecular analysis of matrix remodeling and angiogenesis during long bone development.	FLT1 KDR MMP14	5.67e-06	17	72	3	11165481
Pubmed	Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.	FLT1 KDR FGFR2	5.67e-06	17	72	3	16778080
Pubmed	Wntless is required for peripheral lung differentiation and pulmonary vascular development.	FLT1 KDR FGFR2	9.46e-06	20	72	3	23523683
Pubmed	Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.	TPO FLT1 KDR	1.10e-05	21	72	3	23707896
Pubmed	Vascular endothelial growth factor (VEGF) and VEGF-receptor expression in placenta of hyperglycemic pregnant women.	FLT1 KDR	1.27e-05	3	72	2	20674013
Pubmed	Role and regulation of VEGF and its receptors 1 and 2 in the aseptic loosening of total hip implants.	FLT1 KDR	1.27e-05	3	72	2	22528855
Pubmed	VEGF and his R1 and R2 receptors expression in mast cells of oral squamous cells carcinomas and their involvement in tumoral angiogenesis.	FLT1 KDR	1.27e-05	3	72	2	22203927
Pubmed	Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability.	FLT1 KDR	1.27e-05	3	72	2	12045226
Pubmed	VEGFR1 and PKCα signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner.	FLT1 KDR	1.27e-05	3	72	2	21389833
Pubmed	Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells.	FLT1 KDR	1.27e-05	3	72	2	27401249
Pubmed	Microvascularization and expression of VEGF and its receptors in recurring meningiomas: pathobiological data in favor of anti-angiogenic therapy approaches.	FLT1 KDR	1.27e-05	3	72	2	22541785
Pubmed	Early endocardial morphogenesis requires Scl/Tal1.	FLT1 KDR	1.27e-05	3	72	2	17722983
Pubmed	Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells.	FLT1 KDR	1.27e-05	3	72	2	25329517
Pubmed	The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VEGF activation.	FLT1 KDR	1.27e-05	3	72	2	19633424
Pubmed	Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.	FLT1 KDR	1.27e-05	3	72	2	25756047
Pubmed	Placental vascularisation requires the AP-1 component fra1.	FLT1 KDR	1.27e-05	3	72	2	11044407
Pubmed	Regulation of vascular endothelial growth factor signaling by miR-200b.	FLT1 KDR	1.27e-05	3	72	2	21544626
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT1 KDR FGFR2	1.52e-04	40	47	3	321
GeneFamily	Tubulin tyrosine ligase family	TTLL3 TTLL1	5.90e-04	14	47	2	779
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT1 LRRN3 KDR FGFR2	8.02e-04	161	47	4	593
GeneFamily	Adenosine receptors\|V-set domain containing	HEPACAM MPZL1 KDR VSTM2B	8.40e-04	163	47	4	590
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARAP3 SH2B3 FGD4 OSBPL9	1.99e-03	206	47	4	682
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD4 ZFYVE1	2.93e-03	31	47	2	81
GeneFamily	WD repeat domain containing	PWP1 WDR7 EML4 GEMIN5	4.71e-03	262	47	4	362
GeneFamily	Immunoglobulin like domain containing	HEPACAM FLT1 KDR	1.38e-02	193	47	3	594
Coexpression	GSE32034_UNTREATED_VS_ROSIGLIZATONE_TREATED_LY6C_HIGH_MONOCYTE_UP	WWC2 SH2B3 SLC44A2 GEMIN5 KDR DNAH8	1.74e-05	200	71	6	M9060
Coexpression	GSE3203_UNTREATED_VS_IFNB_TREATED_LN_BCELL_DN	CACNA2D2 SVIL KDR PLEC NEB ZFYVE1	1.74e-05	200	71	6	M6789
Coexpression	DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS	FLT1 STAB2 ARAP3 FGD4 KDR	2.89e-05	131	71	5	M40316
ToppCell	control\|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRN3 ARAP3 MPZL1 PRKDC NCOA4	8.52e-06	171	72	5	837c1186504f110ccf5b580d9cd4e50ca60c173f
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 FLT1 ARAP3 GBGT1 DNAH8	9.53e-06	175	72	5	c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 FLT1 ARAP3 GBGT1 DNAH8	9.53e-06	175	72	5	c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 FLT1 ARAP3 GBGT1 DNAH8	9.53e-06	175	72	5	2f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 SLC44A2 KDR	1.01e-05	177	72	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 DCHS1 KDR NEURL1B	1.06e-05	179	72	5	8f9e538c822940785130297712b75131812a4603
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 DMGDH NCOA4 ABCC6 GAREM1	1.18e-05	183	72	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.28e-05	186	72	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.28e-05	186	72	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.38e-05	189	72	5	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	TPO FLT1 ARAP3 CIITA NEURL1B	1.42e-05	190	72	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WWC2 FLT1 STAB2 ARAP3 KDR	1.45e-05	191	72	5	1924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WWC2 FLT1 STAB2 ARAP3 KDR	1.45e-05	191	72	5	88f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCell	(1)_Control_(PBS)\|World / Stress and Cell class	FLT1 STAB2 MPZL1 KDR MMP14	1.45e-05	191	72	5	b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	WWC2 CACNA2D2 FGFR2 ABCC6 GAREM1	1.49e-05	192	72	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WWC2 FLT1 STAB2 DCHS1 KDR	1.49e-05	192	72	5	6806a1a9fe00395dc1abc3e0124b4261dc701f31
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|(1)_Control_(PBS) / Stress and Cell class	FLT1 STAB2 ARAP3 SVIL KDR	1.49e-05	192	72	5	e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TPO STAB2 CACNA2D2 CYP4F22 DNAH8	1.53e-05	193	72	5	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 ARAP3 SLC26A2 KDR NEURL1B	1.53e-05	193	72	5	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 ARAP3 SLC26A2 KDR NEURL1B	1.53e-05	193	72	5	ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCell	10x5'v1-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLT1 NAALAD2 STAB2 DCHS1 KDR	1.57e-05	194	72	5	e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell	10x5'v1-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLT1 NAALAD2 STAB2 DCHS1 KDR	1.57e-05	194	72	5	953578102ffc7b612ee8fce45e414750800fef5d
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.61e-05	195	72	5	f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.61e-05	195	72	5	ea1b00805391dca8be0883b635768b296369919a
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.61e-05	195	72	5	126f46dd15dddcf5701144718bb8ba1ce84b2d1d
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 ARAP3 DCHS1 KDR	1.61e-05	195	72	5	85df110f753f58ab017018c54ee454edb4428e29
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	FLT1 STAB2 ARAP3 SVIL KDR	1.61e-05	195	72	5	6b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCell	ILEUM-non-inflamed-(3)_moDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SH2B3 CIITA FGD4 SAMHD1 LILRB5	1.65e-05	196	72	5	e10f01172fd076d6892906853f9375d4c3058951
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	TPO FLT1 ARAP3 KDR NEURL1B	1.65e-05	196	72	5	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	Endothelial-capillary_endothelial_cell_(Cap1)\|World / Lineage, Cell type, age group and donor	FLT1 ARAP3 SLC26A2 KDR NEURL1B	1.65e-05	196	72	5	0ce3ed27d2b9276390952652c17a8d6de13add36
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 ARAP3 SLC26A2 KDR NEURL1B	1.69e-05	197	72	5	6a3c647af41fea923311562575a0d656fbc13cbe
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLT1 STAB2 DCHS1 KDR NEURL1B	1.73e-05	198	72	5	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLT1 STAB2 DCHS1 KDR NEURL1B	1.73e-05	198	72	5	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 DCHS1 KDR NEURL1B	1.73e-05	198	72	5	259fbcc0f2ac281a3e4d693de45b986fe5e24841
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WWC2 CACNA2D2 FGD4 FGFR2 GAREM1	1.77e-05	199	72	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WWC2 CACNA2D2 FGD4 FGFR2 GAREM1	1.77e-05	199	72	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 DCHS1 KDR NEURL1B	1.81e-05	200	72	5	b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	WWC2 PTCHD1 FLT1 JMJD4 HMG20A	1.81e-05	200	72	5	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GBGT1 NEURL1B C11orf16 DNAH8	3.52e-05	114	72	4	2cc5d2da5573650c5232a01e2d2128082c4bffcb
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GBGT1 NEURL1B C11orf16 DNAH8	3.52e-05	114	72	4	fceb7cc590a47380145fc0d854c9f2350dbb0a59
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	TPO FLT1 ARAP3 NEURL1B	5.54e-05	128	72	4	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	LA-10._Endothelium_II\|LA / Chamber and Cluster_Paper	TPO FLT1 ARAP3 NEURL1B	6.61e-05	134	72	4	048fa6ccf305d22d9a53db4ab385f39f558010d8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	WWC2 PTCHD1 SLC26A2 ABCC6	1.05e-04	151	72	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	WWC2 PTCHD1 SLC26A2 ABCC6	1.05e-04	151	72	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	PTCHD1 CIITA MUC16 DNAH8	1.41e-04	163	72	4	30f5c93c4e170304d701b5231f0d545f404066f7
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARAP3 KDR PRKCQ C11orf16	1.41e-04	163	72	4	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARAP3 KDR PRKCQ C11orf16	1.41e-04	163	72	4	5d49414432db259a19df50d7944581d00b69f537
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTCHD1 VRK1 CIITA SQLE	1.48e-04	165	72	4	1c630f9ecde2e0243922a2be4b1ab5adcfcb0893
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 ARAP3 KDR PLEC	1.55e-04	167	72	4	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 ARAP3 KDR PLEC	1.55e-04	167	72	4	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 ARAP3 KDR PLEC	1.55e-04	167	72	4	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 ARAP3 KDR PLEC	1.55e-04	167	72	4	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 DCHS1 KDR	1.58e-04	168	72	4	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	droplet-Lung-nan-18m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA CACNA2D2 NEURL1B NUDT17	1.58e-04	168	72	4	96f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	FLT1 ARAP3 CYP4F22 NEURL1B	1.62e-04	169	72	4	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT1 ARAP3 DCHS1 KDR	1.66e-04	170	72	4	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	droplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 VRK1 CIITA SQLE	1.66e-04	170	72	4	545c755b057871b7a22221a049a63a61713dad1d
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT1 ARAP3 DCHS1 KDR	1.66e-04	170	72	4	66d41d794790e621d72ac37af995510537103c9c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 CIITA MUC16 SAMHD1	1.73e-04	172	72	4	72fbfa890995e47048b47199c170cc7dcd7661f8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 CIITA MUC16 SAMHD1	1.73e-04	172	72	4	2ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 FGD4 EML4 SVIL	1.77e-04	173	72	4	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN3 NAALAD2 GBGT1 GAREM1	1.77e-04	173	72	4	a37f38478473290fe35aea8684befc3bf95b161f
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 FGD4 EML4 SVIL	1.77e-04	173	72	4	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	SH2B3 MMP14 LILRB5 GAREM1	1.81e-04	174	72	4	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	MPZL1 SAMHD1 FGFR2 MMP14	1.81e-04	174	72	4	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-ILC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	WWC2 FLT1 JMJD4 HMG20A	1.81e-04	174	72	4	7c50bf9da37711266cc077eef4e54b58463f1d37
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	FLT1 DCHS1 FIP1L1 NEURL1B	1.81e-04	174	72	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 KDR SAMHD1	1.89e-04	176	72	4	3494ffa8555e6edf4b1250e10434bae9b73ec845
ToppCell	droplet-Liver-Npc-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 STAB2 KDR SAMHD1	1.89e-04	176	72	4	d43f6b7828b98e1dab7b726a5f99499d65a7db80
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	FLT1 ARAP3 DCHS1 NEURL1B	1.89e-04	176	72	4	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	severe-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ARAP3 MPZL1 PRKDC NCOA4	1.93e-04	177	72	4	d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN3 SQLE KDR NEURL1B	1.98e-04	178	72	4	742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 NAP1L3 KDR NEURL1B	1.98e-04	178	72	4	6bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TPO FLT1 ARAP3 KDR	2.06e-04	180	72	4	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	TPO FLT1 ARAP3 KDR	2.11e-04	181	72	4	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	Pericytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	LRRN3 FAM178B NAP1L3 NEURL1B	2.11e-04	181	72	4	ff445a8e56522e57e27405184d123cf905caf8cc
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 ARAP3 KDR NEURL1B	2.11e-04	181	72	4	2c660fcf0404c155955b67ab2958d6e6b0e30024
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	PTCHD1 SVIL FGFR2 GAREM1	2.11e-04	181	72	4	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 DMGDH ABCC6 GAREM1	2.15e-04	182	72	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ARAP3 KDR PLEC	2.15e-04	182	72	4	e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ARAP3 KDR PLEC	2.15e-04	182	72	4	ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 STAB2 ARAP3 KDR	2.15e-04	182	72	4	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ARAP3 KDR PLEC	2.15e-04	182	72	4	b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 DMGDH ABCC6 GAREM1	2.15e-04	182	72	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 DMGDH ABCC6 GAREM1	2.15e-04	182	72	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FLT1 ARAP3 KDR NEURL1B	2.20e-04	183	72	4	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 KDR NEURL1B	2.20e-04	183	72	4	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 KDR NEURL1B	2.20e-04	183	72	4	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	Endothelial-A-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	FLT1 DCHS1 KDR NEURL1B	2.20e-04	183	72	4	2c3f2c25c38f0598b4787d2ec335efe00fdc9751
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO FLT1 ARAP3 NEURL1B	2.20e-04	183	72	4	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A GEMIN5 TTLL1 PRKCQ	2.20e-04	183	72	4	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	Cerebellum-Macroglia\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HEPACAM SQLE PRKCQ FGFR2	2.24e-04	184	72	4	91b047a01d2cad231308279ca37fa699630f7864
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 KDR NEURL1B	2.24e-04	184	72	4	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ARAP3 SH2B3 DCHS1	2.29e-04	185	72	4	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	FLT1 ARAP3 DCHS1 NEURL1B	2.29e-04	185	72	4	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-sinusoidal_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FLT1 STAB2 DCHS1 KDR	2.34e-04	186	72	4	e8ead5634686ebaa6a230eea69795d923ce9939d
ToppCell	Endothelial-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	FLT1 ARAP3 DCHS1 KDR	2.34e-04	186	72	4	796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPO FLT1 KDR NEURL1B	2.34e-04	186	72	4	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	facs-SCAT-Fat-24m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ARAP3 MPZL1 KDR	2.38e-04	187	72	4	43e35ec995afd8780893de42ac4ee466794991d7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ARAP3 KDR NEURL1B	2.38e-04	187	72	4	35c382c0aabd46906113e5db30ea24bb8e658899
Drug	Violet Lake	SARS1 SH2B3 SAMHD1	2.89e-07	5	71	3	CID000014885
Drug	prinomastat	FLT1 KDR PRKDC MMP14	3.32e-06	33	71	4	CID000466151
Drug	Cloprostenol	FLT1 KDR FGFR2	4.71e-06	11	71	3	ctd:D003008
Drug	3-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid	FLT1 KDR	9.59e-06	2	71	2	ctd:C477639
Drug	5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one	FLT1 KDR FGFR2	1.58e-05	16	71	3	ctd:C561052
Disease	Multiple Epiphyseal Dysplasia	FLT1 SLC26A2 KDR	1.48e-05	20	71	3	C0026760
Disease	prostate adenocarcinoma (biomarker_via_orthology)	KDR PRKCQ	1.71e-05	3	71	2	DOID:2526 (biomarker_via_orthology)
Disease	cerebral cavernous malformation (is_marker_for)	FLT1 KDR	1.71e-05	3	71	2	DOID:0060669 (is_marker_for)
Disease	allergic contact dermatitis (is_marker_for)	FLT1 KDR	1.71e-05	3	71	2	DOID:3042 (is_marker_for)
Disease	arteriovenous malformations of the brain (is_marker_for)	FLT1 KDR	1.71e-05	3	71	2	DOID:0060688 (is_marker_for)
Disease	Adenocarcinoma of lung (disorder)	FLT1 EML4 KDR PRKDC FGFR2	1.42e-04	206	71	5	C0152013
Disease	arteriosclerosis (biomarker_via_orthology)	KDR MMP14	1.58e-04	8	71	2	DOID:2349 (biomarker_via_orthology)
Disease	red blood cell density measurement	WWC2 DENND4A CIITA SMG5 PLEC NCOA4 ZFYVE1 ABCC6 HMG20A	2.55e-04	880	71	9	EFO_0007978
Disease	thyroid gland carcinoma (is_marker_for)	FLT1 KDR	3.71e-04	12	71	2	DOID:3963 (is_marker_for)
Disease	retinopathy of prematurity (biomarker_via_orthology)	FLT1 KDR	3.71e-04	12	71	2	DOID:13025 (biomarker_via_orthology)
Disease	macular retinal edema (is_marker_for)	FLT1 KDR	3.71e-04	12	71	2	DOID:4449 (is_marker_for)
Disease	juvenile rheumatoid arthritis (is_implicated_in)	CIITA SLC26A2	4.38e-04	13	71	2	DOID:676 (is_implicated_in)
Disease	transitional cell carcinoma (is_marker_for)	KDR FGFR2 MMP14	4.78e-04	63	71	3	DOID:2671 (is_marker_for)
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 KDR	6.70e-04	16	71	2	C4551479
Disease	Spondyloepiphyseal Dysplasia	FLT1 KDR	6.70e-04	16	71	2	C0038015
Disease	Schwartz-Jampel Syndrome	FLT1 KDR	6.70e-04	16	71	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 KDR	6.70e-04	16	71	2	C0025237
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 KDR	6.70e-04	16	71	2	C3541456
Disease	Moyamoya Disease	SAMHD1 ABCC6	7.58e-04	17	71	2	C0026654
Disease	Van Buchem disease	FLT1 KDR	7.58e-04	17	71	2	C0432272
Disease	Kuhnt-Junius degeneration (is_implicated_in)	FLT1 KDR	7.58e-04	17	71	2	DOID:10873 (is_implicated_in)
Disease	Uremia	FLT1 KDR	7.58e-04	17	71	2	C0041948
Disease	Hemangiosarcoma	FLT1 KDR	8.52e-04	18	71	2	C0018923
Disease	Dyschondroplasias	FLT1 KDR	9.51e-04	19	71	2	C0013366
Disease	factor VIII measurement, Ischemic stroke	STAB2 SH2B3	9.51e-04	19	71	2	EFO_0004630, HP_0002140
Disease	Osteochondrodysplasias	FLT1 KDR	9.51e-04	19	71	2	C0029422
Disease	esophagus adenocarcinoma (is_implicated_in)	KDR MMP14	1.16e-03	21	71	2	DOID:4914 (is_implicated_in)
Disease	peak expiratory flow	DMGDH EML4 SVIL KDR MMP14 HMG20A	1.27e-03	498	71	6	EFO_0009718
Disease	myocardial infarction (is_implicated_in)	CIITA KDR MMP14	1.77e-03	99	71	3	DOID:5844 (is_implicated_in)
Disease	Liver Cirrhosis	FLT1 FGFR2 PLOD2	1.99e-03	103	71	3	C0023890
Disease	Cerebral Hemorrhage	FLT1 KDR	2.07e-03	28	71	2	C2937358
Disease	Fibrosis, Liver	FLT1 FGFR2 PLOD2	2.10e-03	105	71	3	C0239946
Disease	arteriosclerosis (is_marker_for)	KDR MMP14	2.22e-03	29	71	2	DOID:2349 (is_marker_for)
Disease	Dupuytren Contracture	KDR FGFR2 MMP14	2.27e-03	108	71	3	EFO_0004229
Disease	right ventricular ejection fraction measurement	SVIL PLEC	2.38e-03	30	71	2	EFO_0021816
Disease	Ischemic stroke, von Willebrand factor measurement	STAB2 SH2B3	2.38e-03	30	71	2	EFO_0004629, HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPSRLYKPTKGWEER	CCDC112	401	Q8NEF3
KPEREWPLEGAKVYL	ARAP3	1266	Q8WWN8
PATPWRAPKKIDLYD	CACNA2D2	261	Q9NY47
PRKKRPYDNWLEGVP	CIITA	741	P33076
LYKDSWLLREGLNKP	ACTR8	86	Q9H981
YRKWLGPENIPERFK	AADACL3	281	Q5VUY0
LKVEPGYPKSALRDW	MMP14	491	P50281
DKPPLTDLGVLYDWK	DENND4A	96	Q7Z401
WVYDEPLLKRLGAAK	OSBPL9	721	Q96SU4
YELPEDPKWEFPRDK	FGFR2	466	P21802
DPKWEFPRDKLTLGK	FGFR2	471	P21802
PKSPGLDRERLYWKL	MUC16	13401	Q8WXI7
DPKSPGLDREQLYWE	MUC16	13556	Q8WXI7
PDTWYKGRKAGLLLP	DCHS1	3086	Q96JQ0
PFYPRWLEKEAKDLL	PRKCQ	596	Q04759
KSAAYLDPGPAKEEW	NUDT17	301	P0C025
WSKLPPEEKQRYLDE	HMG20A	141	Q9NP66
RWYKEAKPGAAEPEV	PDE12	196	Q6L8Q7
PFISRGKELLWGKPE	TPO	21	P07202
DLKACPPKPYRWILD	DNAH8	3791	Q96JB1
DYLRKLPPDSLDWND	FGD4	361	Q96M96
PGKSELPYEELWLEE	GAREM1	446	Q9H706
DLDSFEDKPWRKPGA	FIP1L1	156	Q6UN15
EDKPWRKPGADLSDY	FIP1L1	161	Q6UN15
EIRKLYPEGKLPHWL	MED23	186	Q9ULK4
PPKEWKPRQCYDDID	KDM4C	51	Q9H3R0
EEYRLDKEGLPWARK	LILRB5	56	O75023
PPFKDRISWAGDLDK	MPZL1	101	O95297
LLPYWRDVAEAKPEL	IAH1	226	Q2TAA2
DGILWPDKRLADKYP	PLOD2	141	O00469
EWLIRPPYKEGSPKE	NCOA4	496	Q13772
VLERLDPNPEYWEGK	TTC26	486	A0AVF1
SKVLSPEYLWDDRKP	GBGT1	311	Q8N5D6
RKKWLLFPPGQEEAL	JMJD4	251	Q9H9V9
WRKLLKGIPDLYDDA	SQLE	431	Q14534
PFDLIELDPNRYGKW	DMGDH	421	Q9UI17
YGFWCPRELKIDPDL	FZD3	161	Q9NPG1
PSYTWLKDGKPLLND	HEPACAM	176	Q14CZ8
YWALRKPDDLPAFPL	SLC44A2	476	Q8IWA5
LWDALKYLGEPIKSE	GLB1L2	396	Q8IW92
RTELPPEKLKLEWAY	EML4	251	Q9HC35
APKDDLFYGFLKPWL	CYP4F22	126	Q6NT55
RPYGSDKPWPSLLDK	NKAP	106	Q8N5F7
RDEWLRPEDLPIKYA	SARS1	281	P49591
PVDYGRKAEELLWRK	SMG5	71	Q9UPR3
DKLVPDDDYWGKIPK	SVIL	1571	O95425
EDSLWPYKGRPENKS	SAMHD1	281	Q9Y3Z3
LYPPLINLWEAGKEK	LRRN3	676	Q9H3W5
DPKPPAWKGYLLAVL	ABCC6	341	O95255
KPEALQEKPAWYRFL	PTCHD1	446	Q96NR3
LDPKRGLALPEKLFW	FAM178B	161	Q8IXR5
PDPFIRWSKDGKELR	SPEGNB	81	A0A087WV53
EDPKGIPDYWLIVLK	NAP1L3	306	Q99457
YSLRPGDKVLALWEP	C11orf16	151	Q9NQ32
ADKYVKIWDILGDRP	PWP1	406	Q13610
FKGPELWESKLDAKP	WASHC5	61	Q12768
PLPRGWEEARDYDGK	WWC2	11	Q6AWC2
GFLPVLQWLPKYDLK	SLC26A2	91	P50443
WYLKEPPRELLHELA	VSTM2B	66	A6NLU5
RPEDPVLKDLYLSWG	GEMIN5	1016	Q8TEQ6
PADPDALLDRKEYWV	NEURL1B	356	A8MQ27
RENYPLPWEKDTEKL	GPLD1	101	P80108
PGLAKKFLPWSLARE	SH2B3	176	Q9UQQ2
LDKAYAWPLSKLGPF	STAB2	391	Q8WWQ8
KFEELERAPGDPKWL	TBC1D10B	386	Q4KMP7
DKDLEAPLYLTPEGW	TTLL3	216	Q9Y4R7
PGYHPLDVEKEWGKL	PLEC	496	Q15149
TGHLPWEDNLKDPKY	VRK1	256	Q99986
DPRAPPCEYKDWLTK	PRKDC	3831	P78527
GLVKDAARPAYWVPD	ZFYVE1	701	Q9HBF4
PYDASKWEFPRDRLK	KDR	821	P35968
PDYVRKGDTRLPLKW	FLT1	1051	P17948
AGRKEAIDAWAPYLP	WDR7	1041	Q9Y4E6
GYDIIIDDKLKPWLI	TTLL1	311	O95922
LRYLGGIAPPDKSWK	NAALAD2	296	Q9Y3Q0
WEDTKDKYLLPPDAP	NEB	176	P20929