Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	odorant binding	OR5W2 OR14K1 OR10J4 OR10J1 OR10J3	1.69e-06	127	32	5	GO:0005549
GeneOntologyMolecularFunction	olfactory receptor activity	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	4.39e-06	431	32	7	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5W2 OR10G6 OR14K1 S1PR2 OR10J4 OR1J1 OR10J1 CXCR4 OR10J3	7.01e-06	884	32	9	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5W2 OR10G6 OR14K1 S1PR2 OR10J4 OR1J1 OR10J1 CXCR4 OR10J3	1.98e-04	1353	32	9	GO:0004888
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 CXCR4 OR10J3	2.21e-06	582	32	8	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR5W2 OR10G6 OR14K1 ATP6V1B1 DRAM2 OR10J4 OR1J1 OR10J1 CXCR4 OR10J3	3.12e-06	1072	32	10	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	3.60e-06	432	32	7	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	5.84e-06	465	32	7	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	7.70e-06	485	32	7	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 CXCR4 OR10J3	1.08e-05	722	32	8	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	1.27e-05	524	32	7	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	1.68e-05	547	32	7	GO:0007606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR5W2 OR10G6 OR14K1 S1PR2 OR10J4 CAV1 OR1J1 OR10J1 CXCR4 OR10J3	3.16e-05	1395	32	10	GO:0007186
GeneOntologyBiologicalProcess	positive regulation of endothelial cell development	S1PR2 ADD1	6.49e-05	8	32	2	GO:1901552
GeneOntologyBiologicalProcess	positive regulation of establishment of endothelial barrier	S1PR2 ADD1	6.49e-05	8	32	2	GO:1903142
GeneOntologyBiologicalProcess	endothelial cell differentiation	S1PR2 CXCR4 ADD1 RBPJ	1.01e-04	158	32	4	GO:0045446
GeneOntologyBiologicalProcess	endothelium development	S1PR2 CXCR4 ADD1 RBPJ	1.74e-04	182	32	4	GO:0003158
GeneOntologyBiologicalProcess	piecemeal microautophagy of the nucleus	SNX30 ATG4D	3.51e-04	18	32	2	GO:0034727
GeneOntologyBiologicalProcess	regulation of endothelial cell development	S1PR2 ADD1	4.35e-04	20	32	2	GO:1901550
GeneOntologyBiologicalProcess	regulation of establishment of endothelial barrier	S1PR2 ADD1	4.35e-04	20	32	2	GO:1903140
GeneOntologyBiologicalProcess	morphogenesis of an endothelium	CXCR4 RBPJ	4.81e-04	21	32	2	GO:0003159
GeneOntologyBiologicalProcess	endothelial tube morphogenesis	CXCR4 RBPJ	4.81e-04	21	32	2	GO:0061154
GeneOntologyBiologicalProcess	nucleophagy	SNX30 ATG4D	5.78e-04	23	32	2	GO:0044804
GeneOntologyBiologicalProcess	microautophagy	SNX30 ATG4D	6.30e-04	24	32	2	GO:0016237
Domain	7tm_1	OR5W2 OR10G6 OR14K1 S1PR2 OR1J1 OR10J1 CXCR4 OR10J3	1.08e-05	677	31	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5W2 OR10G6 OR14K1 S1PR2 OR1J1 OR10J1 CXCR4 OR10J3	1.17e-05	685	31	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5W2 OR10G6 OR14K1 S1PR2 OR1J1 OR10J1 CXCR4 OR10J3	1.25e-05	691	31	8	PS50262
Domain	GPCR_Rhodpsn	OR5W2 OR10G6 OR14K1 S1PR2 OR1J1 OR10J1 CXCR4 OR10J3	1.26e-05	692	31	8	IPR000276
Domain	Olfact_rcpt	OR5W2 OR10G6 OR14K1 OR1J1 OR10J1 OR10J3	3.94e-05	393	31	6	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR5W2 S1PR2 OR1J1 OR10J1 CXCR4 OR10J3	7.12e-04	670	31	6	IPR017452
Domain	-	WDR74 SEMA3C CFAP251 WDR64	2.14e-03	333	31	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR74 SEMA3C CFAP251 WDR64	2.18e-03	335	31	4	IPR015943
Domain	WD40	WDR74 CFAP251 WDR64	8.90e-03	259	31	3	PF00400
Domain	WD40	WDR74 CFAP251 WDR64	9.76e-03	268	31	3	SM00320
Domain	WD40_repeat	WDR74 CFAP251 WDR64	1.02e-02	272	31	3	IPR001680
Domain	WD_REPEATS_1	WDR74 CFAP251 WDR64	1.08e-02	278	31	3	PS00678
Domain	WD_REPEATS_2	WDR74 CFAP251 WDR64	1.09e-02	279	31	3	PS50082
Domain	WD_REPEATS_REGION	WDR74 CFAP251 WDR64	1.09e-02	279	31	3	PS50294
Domain	WD40_repeat_dom	WDR74 CFAP251 WDR64	1.29e-02	297	31	3	IPR017986
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	5.71e-06	417	25	7	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR5W2 OR10G6 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	8.68e-05	636	25	7	M41834
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5W2 OR14K1 OR10J4 OR1J1 OR10J1 OR10J3	4.60e-08	219	32	6	12213199
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5W2 OR10G6 ATP6V1B1 OR1J1 OR10J1 OR10J3	6.76e-07	346	32	6	14611657
Pubmed	Breast cancer nodal metastasis correlates with tumour and lymph node methylation profiles of Caveolin-1 and CXCR4.	CAV1 CXCR4	8.20e-07	2	32	2	24590865
Pubmed	Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells.	CXCR4 RBPJ	8.20e-07	2	32	2	23474530
Pubmed	Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4.	CXCR4 RBPJ	8.20e-07	2	32	2	19357083
Pubmed	Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice.	CXCR4 RBPJ	2.46e-06	3	32	2	19859544
Pubmed	Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.	CAV1 ASAH2	2.46e-06	3	32	2	12921776
Pubmed	Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.	CAV1 ASAH2	4.92e-06	4	32	2	24397980
Pubmed	CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1.	LIMK1 CXCR4	4.92e-06	4	32	2	25359780
Pubmed	Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.	CAV1 ASAH2	4.92e-06	4	32	2	11591392
Pubmed	Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.	CAV1 CXCR4	8.19e-06	5	32	2	22275353
Pubmed	LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.	LIMK1 CXCR4	8.19e-06	5	32	2	21321123
Pubmed	The human olfactory receptor gene family.	OR5W2 OR10G6 OR14K1 OR1J1 OR10J1 OR10J3	8.86e-06	541	32	6	14983052
Pubmed	CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.	LIMK1 CXCR4	1.23e-05	6	32	2	24778234
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5W2 OR10G6 OR1J1 OR10J1 OR10J3	1.41e-05	340	32	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5W2 OR10G6 OR1J1 OR10J1 OR10J3	1.41e-05	340	32	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5W2 OR10G6 OR1J1 OR10J1 OR10J3	1.47e-05	343	32	5	32295537
Pubmed	Chemerin, a novel adipokine in the regulation of angiogenesis.	OR10J1 OR10J3	2.29e-05	8	32	2	20237162
Pubmed	Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.	CXCR4 RBPJ	2.94e-05	9	32	2	28714968
Pubmed	Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.	LIMK1 CXCR4	7.41e-05	14	32	2	20041213
Pubmed	ETS factors regulate Vegf-dependent arterial specification.	CXCR4 RBPJ	8.55e-05	15	32	2	23830865
Pubmed	Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.	OR10J1 OR10J3	1.39e-04	19	32	2	22939635
Pubmed	Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.	CAV1 RBPJ	1.54e-04	20	32	2	20133625
Pubmed	Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.	ATP6V1B1 RBPJ	1.70e-04	21	32	2	24583262
Pubmed	Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.	ATP6V1B1 RBPJ	1.87e-04	22	32	2	28215940
Pubmed	Genome-wide association with select biomarker traits in the Framingham Heart Study.	OR10J1 OR10J3	2.05e-04	23	32	2	17903293
Pubmed	Pofut1 is required for the proper localization of the Notch receptor during mouse development.	CAV1 RBPJ	2.05e-04	23	32	2	18547789
Pubmed	Specification of CNS macrophage subsets occurs postnatally in defined niches.	CXCR4 RBPJ	2.84e-04	27	32	2	35444273
Pubmed	CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.	CAV1 CXCR4 RBPJ	3.29e-04	146	32	3	29688375
Pubmed	Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.	CXCR4 RBPJ	3.51e-04	30	32	2	20890042
Cytoband	1q23.2	OR10J4 OR10J1 OR10J3	1.98e-06	35	32	3	1q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1q23	OR10J4 OR10J1 OR10J3	5.25e-04	226	32	3	chr1q23
Cytoband	12q24.31	KDM2B CFAP251	1.44e-03	80	32	2	12q24.31
GeneFamily	Olfactory receptors, family 10	OR10G6 OR10J4 OR10J1 OR10J3	1.36e-06	66	23	4	157
GeneFamily	Autophagy related	SNX30 ATG4D	7.98e-04	33	23	2	1022
GeneFamily	WD repeat domain containing	WDR74 CFAP251 WDR64	4.30e-03	262	23	3	362
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SEMA3C SPEG	1.76e-02	161	23	2	593
Disease	ICAM-1 measurement	S1PR2 ATG4D	2.54e-04	24	29	2	EFO_0004520
Disease	CCL2 measurement	OR10J4 OR10J1 OR10J3	2.56e-04	126	29	3	EFO_0004749
Disease	growth-regulated alpha protein measurement	OR10J1 OR10J3	1.34e-03	55	29	2	EFO_0008146
Disease	cardiomyopathy (implicated_via_orthology)	CXCR4 ASAH2	2.22e-03	71	29	2	DOID:0050700 (implicated_via_orthology)
Disease	fasting blood glucose measurement	KDM2B SNX30 AGO1	2.76e-03	287	29	3	EFO_0004465
Disease	Alloxan Diabetes	S1PR2 CAV1	5.05e-03	108	29	2	C0002152
Disease	Streptozotocin Diabetes	S1PR2 CAV1	5.05e-03	108	29	2	C0038433
Disease	Diabetes Mellitus, Experimental	S1PR2 CAV1	5.05e-03	108	29	2	C0011853
Disease	monocyte percentage of leukocytes	CAV1 CXCR4 ADD1 RBPJ	5.42e-03	731	29	4	EFO_0007989
Disease	lifestyle measurement, alcohol consumption measurement	OR10J4 OR10J1	5.71e-03	115	29	2	EFO_0007878, EFO_0010724

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVHVIYTVNLYSSVL	CXCR4	111	P61073
ELQILTYQLCHTYVR	AGO1	776	Q9UL18
IQCISRVYSIYVHTV	CAV1	141	Q03135
QRVLLYVCAHTAIIY	CFAP251	271	Q8TBY9
ISYCYIILSVLEIHS	OR5W2	216	Q8NH69
ETHRVYAIVLVSAYT	RBBP9	86	O75884
TVVISGLCNVYTHYI	ASAH2	566	Q9NR71
CIVVSYVYIFSAVLR	OR14K1	211	Q8NGZ2
LCIATIYVRYKQVHA	DRAM2	66	Q6UX65
CGSHLSVVTIYYRTI	OR1J1	241	Q8NGS3
VLERYVYCVTQRSHL	KDM2B	366	Q8NHM5
KQNTIHYTVRVYSAC	CAPN7	661	Q9Y6W3
YAKHYVLCVVTIFSI	S1PR2	186	O95136
VALYVRIYCVVRSSH	S1PR2	206	O95136
HVYTAVTRGRCRVYV	HELB	911	Q8NG08
TVVIVHYSCASIAYL	OR10J1	256	P30954
TCAAHLTVVIVYYVP	OR10G6	261	Q8NH81
LTVVIIHYGCASIIY	OR10J3	246	Q5JRS4
LTVVIVHYGRTSFIY	OR10J4	246	P0C629
RNYITHPRVTYRTVC	ATP6V1B1	31	P15313
VRVIQTFNRTHLYVC	SEMA3C	116	Q99985
QQRVVRVYCYVTVVS	TMEM161A	361	Q9NX61
DHYVQRSAYCSIVVT	TDRD9	171	Q8NDG6
YYIHNLVVACEIQVR	ADD1	316	P35611
VTRLVVYVSQDCTVY	ATG4D	266	Q86TL0
QKLVTCTGYHQVRVY	WDR74	196	Q6RFH5
CYYNVTHLPVGVTVR	SPEG	2731	Q15772
HVCTMETYITYRITT	SNX30	101	Q5VWJ9
LYSYVIEVLICLHTR	SMCO1	76	Q147U7
YIHYGQTVKLVCSVT	RBPJ	241	Q06330
YFHQVLTICSESIIR	WDR64	466	B1ANS9
QVIFEARSICIHYVT	KCNH8	286	Q96L42
HCYYQTVVTPVIEQI	LIMK1	136	P53667