Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H2A kinase activity	DCAF1 BUB1	5.36e-05	3	85	2	GO:0140995
GeneOntologyMolecularFunction	histone kinase activity	DCAF1 BUB1 ATM	2.26e-04	28	85	3	GO:0035173
GeneOntologyMolecularFunction	WD40-repeat domain binding	DDB1 USP47	2.66e-04	6	85	2	GO:0071987
GeneOntologyCellularComponent	GATOR1 complex	SZT2 DEPDC5	1.62e-04	5	85	2	GO:1990130
GeneOntologyCellularComponent	cluster of actin-based cell projections	SLC7A9 PLB1 MYH14 MYO15A USH2A B4GALT1	2.99e-04	223	85	6	GO:0098862
Domain	Solute_trans_a	TMEM184A TMEM184C	1.28e-04	4	87	2	PF03619
Domain	Ostalpha/TMEM184C	TMEM184A TMEM184C	1.28e-04	4	87	2	IPR005178
Domain	Cadherin_CS	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	1.56e-04	109	87	5	IPR020894
Domain	CADHERIN_1	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	1.85e-04	113	87	5	PS00232
Domain	Cadherin	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	1.85e-04	113	87	5	PF00028
Domain	CADHERIN_2	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	1.92e-04	114	87	5	PS50268
Domain	-	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	1.92e-04	114	87	5	2.60.40.60
Domain	CA	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	2.00e-04	115	87	5	SM00112
Domain	Cadherin-like	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	2.09e-04	116	87	5	IPR015919
Domain	Cadherin	CELSR3 DCHS1 PCDHAC1 CDH7 CDHR4	2.26e-04	118	87	5	IPR002126
Pubmed	Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance.	DCAF1 ATM DDB1	1.30e-06	9	88	3	19275579
Pubmed	HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.	DCAF1 ATM DDB1	1.85e-06	10	88	3	18514189
Pubmed	Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.	DCAF1 DDB1	6.33e-06	2	88	2	24558487
Pubmed	Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.	DCAF1 DDB1	6.33e-06	2	88	2	25499532
Pubmed	Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.	DCAF1 DDB1	6.33e-06	2	88	2	24912982
Pubmed	Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.	ADSS2 ATM	6.33e-06	2	88	2	19115993
Pubmed	The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.	DCAF1 DDB1	6.33e-06	2	88	2	19264781
Pubmed	HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.	DCAF1 DDB1	6.33e-06	2	88	2	17559673
Pubmed	Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.	ATM WDR17	6.33e-06	2	88	2	26536348
Pubmed	HIV-1 Vpr-a still "enigmatic multitasker".	DCAF1 ATM DDB1	8.56e-06	16	88	3	24744753
Pubmed	Structure-function relationship of Vpr: biological implications.	DCAF1 ATM DDB1	8.56e-06	16	88	3	19275588
Pubmed	Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions.	DCAF1 DDB1	1.90e-05	3	88	2	20069611
Pubmed	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	VAC14 ATM	1.90e-05	3	88	2	24240686
Pubmed	Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex.	DCAF1 DDB1	1.90e-05	3	88	2	35938868
Pubmed	HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7.	DCAF1 DDB1	1.90e-05	3	88	2	33648539
Pubmed	The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover.	DCAF1 DDB1	1.90e-05	3	88	2	22292079
Pubmed	HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.	DCAF1 DDB1	1.90e-05	3	88	2	22362772
Pubmed	Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.	DCAF1 DDB1	1.90e-05	3	88	2	28202763
Pubmed	HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.	DCAF1 DDB1	1.90e-05	3	88	2	17314515
Pubmed	HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.	DCAF1 DDB1	1.90e-05	3	88	2	19667756
Pubmed	Structural basis of lentiviral subversion of a cellular protein degradation pathway.	DCAF1 DDB1	1.90e-05	3	88	2	24336198
Pubmed	HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.	DCAF1 DDB1	1.90e-05	3	88	2	17630831
Pubmed	HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing.	DCAF1 DDB1	1.90e-05	3	88	2	31511615
Pubmed	CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulation.	DCAF1 DDB1	1.90e-05	3	88	2	25371539
Pubmed	HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.	DCAF1 DDB1	1.90e-05	3	88	2	26032416
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	CELSR3 MYH14 PSMA4 WDR17 USH2A DDB1	2.77e-05	231	88	6	36597993
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	FKBP15 MSH6 SZT2 DEPDC5 USP47	3.72e-05	147	88	5	29576527
Pubmed	Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.	DCAF1 DDB1	3.79e-05	4	88	2	18464893
Pubmed	The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.	DCAF1 DDB1	3.79e-05	4	88	2	17620334
Pubmed	The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction.	DCAF1 DDB1	3.79e-05	4	88	2	27571178
Pubmed	VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.	DCAF1 DDB1	3.79e-05	4	88	2	28416635
Pubmed	DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.	DCAF1 DDB1	3.79e-05	4	88	2	17626091
Pubmed	DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor.	DCAF1 DDB1	3.79e-05	4	88	2	30590706
Pubmed	Modulation of NKG2D-mediated cytotoxic functions of natural killer cells by viral protein R from HIV-1 primary isolates.	DCAF1 DDB1	3.79e-05	4	88	2	21957298
Pubmed	The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis.	BUB1 ATM	3.79e-05	4	88	2	20663956
Pubmed	Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.	ATM USP47	3.79e-05	4	88	2	32377397
Pubmed	HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest.	DCAF1 DDB1	3.79e-05	4	88	2	20089662
Pubmed	XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer.	XRRA1 ATM	3.79e-05	4	88	2	29082250
Pubmed	CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.	DCAF1 DDB1	3.79e-05	4	88	2	26281983
Pubmed	Vpr and its interactions with cellular proteins.	DCAF1 ATM DDB1	4.90e-05	28	88	3	20012529
Pubmed	An investigation into the human serum "interactome".	CACNA1I ATM DDB1 ITGB5 IGDCC4	5.91e-05	162	88	5	15174051
Pubmed	SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.	DCAF1 DDB1	6.30e-05	5	88	2	24703702
Pubmed	Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.	DCAF1 DDB1	6.30e-05	5	88	2	26170450
Pubmed	HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.	DCAF1 DDB1	6.30e-05	5	88	2	23612978
Pubmed	Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.	DCAF1 DDB1	6.30e-05	5	88	2	27721409
Pubmed	Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.	DCAF1 DDB1	6.30e-05	5	88	2	20178741
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	DCAF1 DDB1	6.30e-05	5	88	2	24719410
Pubmed	S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.	DCAF1 DDB1	6.30e-05	5	88	2	37151881
Pubmed	Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.	DCAF1 DDB1	6.30e-05	5	88	2	25532805
Pubmed	EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.	DCAF1 DDB1	6.30e-05	5	88	2	23063525
Pubmed	Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?	DCAF1 DDB1	6.30e-05	5	88	2	20380700
Pubmed	HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.	DCAF1 DDB1	6.30e-05	5	88	2	23677995
Pubmed	CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.	DCAF1 DDB1	6.30e-05	5	88	2	25557551
Pubmed	HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.	DCAF1 DDB1	9.43e-05	6	88	2	22438978
Pubmed	CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.	DCAF1 DDB1	9.43e-05	6	88	2	22570418
Pubmed	SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).	DCAF1 DDB1	9.43e-05	6	88	2	27354282
Pubmed	CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.	DCAF1 DDB1	9.43e-05	6	88	2	34259627
Pubmed	HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.	DCAF1 DDB1	9.43e-05	6	88	2	20870715
Pubmed	The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.	DCAF1 DDB1	9.43e-05	6	88	2	26613412
Pubmed	Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.	DCAF1 DDB1	9.43e-05	6	88	2	23362280
Pubmed	HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection.	DCAF1 DDB1	9.43e-05	6	88	2	30352932
Pubmed	HIV: Ringside views.	DCAF1 DDB1	9.43e-05	6	88	2	24402277
Pubmed	HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.	DCAF1 DDB1	9.43e-05	6	88	2	26679995
Pubmed	Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.	ADSS2 PSMA4 DLX1	1.05e-04	36	88	3	15745951
Pubmed	From arrest to escape: HIV-1 Vpr cuts a deal.	DCAF1 DDB1	1.32e-04	7	88	2	24528857
Pubmed	Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.	DCAF1 DDB1	1.32e-04	7	88	2	28242748
Pubmed	HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.	DCAF1 DDB1	1.32e-04	7	88	2	20008788
Pubmed	HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.	DCAF1 DDB1	1.32e-04	7	88	2	29724823
Pubmed	Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.	DCAF1 DDB1	1.32e-04	7	88	2	22072767
Pubmed	ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.	CCNG1 ATM	1.32e-04	7	88	2	21460856
Pubmed	VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.	DCAF1 DDB1	1.32e-04	7	88	2	18332868
Pubmed	Exportin 7 defines a novel general nuclear export pathway.	ARHGAP1 XPO7	1.32e-04	7	88	2	15282546
Pubmed	VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.	DCAF1 DDB1	1.32e-04	7	88	2	22157821
Pubmed	Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.	DCAF1 DDB1	1.32e-04	7	88	2	37024504
Pubmed	A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis.	PSMA4 ATM	1.32e-04	7	88	2	27918549
Pubmed	The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection.	DCAF1 DDB1	1.32e-04	7	88	2	23849790
Pubmed	Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.	MSH6 XPO7	1.32e-04	7	88	2	24038355
Pubmed	HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.	DCAF1 DDB1	1.32e-04	7	88	2	19798433
Pubmed	Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.	DCAF1 ATM	1.75e-04	8	88	2	22184063
Pubmed	HIV-1 Vpr: a novel role in regulating RNA splicing.	DCAF1 DDB1	1.75e-04	8	88	2	19275585
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	MYO15A USH2A	2.25e-04	9	88	2	23144817
Pubmed	HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.	DCAF1 DDB1	2.25e-04	9	88	2	24116224
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 DDB1	2.25e-04	9	88	2	17855541
Pubmed	The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.	DCAF1 DDB1	2.25e-04	9	88	2	33524014
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	FKBP15 MSH6 EEF2 ADSS2 PSMA4 ATM MED23 MYO15A DDB1 XPO7	2.45e-04	1014	88	10	32416067
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MSH6 MYH14 ATAD2B BEND3 ATM DDB1 USP47 XPO7	2.54e-04	653	88	8	22586326
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EEF2 WDR4 CTDSPL2 MYH14 EIF4A2 CEP83 TMEM184C BEND3 EIF2AK4 ATM EHD4 BAHCC1	2.75e-04	1442	88	12	35575683
Pubmed	NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.	DCAF1 DDB1	2.81e-04	10	88	2	33058421
Pubmed	The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.	DCAF1 DDB1	2.81e-04	10	88	2	20347598
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	CFAP100 DCAF1 VAC14 VPS37A DDB1 ITGB5	3.32e-04	364	88	6	31391242
Pubmed	PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.	CFAP100 FKBP15 PSMA4 ARHGEF25	3.41e-04	130	88	4	26598620
Pubmed	Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.	DCAF1 DDB1	3.43e-04	11	88	2	24412650
Pubmed	SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.	MSH6 ATM	3.43e-04	11	88	2	11877377
Pubmed	BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.	MSH6 ATM	4.11e-04	12	88	2	10783165
Pubmed	Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.	EEF2 MED23	4.11e-04	12	88	2	15749018
Pubmed	DDB1 is essential for genomic stability in developing epidermis.	ATM DDB1	4.85e-04	13	88	2	17301228
Pubmed	Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.	DCAF1 DDB1	5.65e-04	14	88	2	18606781
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	EEF2 AHI1 PRAMEF22 PSMA4 EIF4A2 MYO15A DDB1	5.81e-04	564	88	7	21565611
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	MSH6 EEF2 MYH14 PSMA4 EIF4A2 DDB1 EHD4	5.87e-04	565	88	7	33567341
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 FKBP15 DOCK9 BEND3 IGDCC4 XPO7	5.98e-04	407	88	6	12693553
Cytoband	3p21.2	DCAF1 PPM1M	6.08e-04	19	88	2	3p21.2
Cytoband	12q22	CEP83 FGD6	2.84e-03	41	88	2	12q22
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	CTDSPL2 EIF2AK4 EHD4	2.89e-03	147	88	3	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	DCAF1 CELSR3 PPM1M CDHR4	3.26e-03	316	88	4	chr3p21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF19 ARHGEF25 FGD6	1.31e-03	66	59	3	722
GeneFamily	Cadherin related	DCHS1 CDHR4	1.38e-03	17	59	2	24
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPY19L3 VPS37A BEND3 RASEF AP3S2 XPO7	1.24e-06	173	88	6	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DCAF1 MYH14 C1orf167 FGD6 IGDCC4	1.02e-05	145	88	5	80684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DCAF1 MYH14 C1orf167 FGD6 IGDCC4	1.02e-05	145	88	5	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF19 RASEF SEPTIN12 BCO1 CA8	2.54e-05	175	88	5	24651f95540ea2c8f3720aa943cbdd15661ee3fa
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP100 PLB1 TMEM184A DLX1 BCO1	3.14e-05	183	88	5	4de2082dca2569d3aac3c9b466f27971c82d302b
ToppCell	droplet-Heart-4Chambers-21m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP100 PLB1 TMEM184A DLX1 BCO1	3.14e-05	183	88	5	a046b569bc10083d471b420eb2c6fee93437602d
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP100 PLB1 TMEM184A MYH14 RASEF	3.40e-05	186	88	5	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP100 PLB1 TMEM184A MYH14 RASEF	3.40e-05	186	88	5	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP100 PLB1 TMEM184A MYH14 RASEF	3.40e-05	186	88	5	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM184A MYH14 RASEF PTGER4 GSDMC	4.05e-05	193	88	5	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ARHGEF19 MYH14 XRRA1 MYO15A WDR17	4.68e-05	199	88	5	121de4e02585de3a3010398387c523bacf8ce546
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	AHI1 ZPBP DNAH17 ITGB5 CDH7	4.79e-05	200	88	5	f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	ARHGAP1 ADSS2 FGD6 DDB1 EHD4	4.79e-05	200	88	5	1fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	AHI1 ZPBP DNAH17 ITGB5 CDH7	4.79e-05	200	88	5	70a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	AHI1 ZPBP DNAH17 ITGB5 CDH7	4.79e-05	200	88	5	1639982d9d994918f7912d12d9d7cfcbc9da4145
Disease	fecal incontinence	PLB1 CDH7	8.15e-05	5	85	2	EFO_0009523
Disease	thioredoxin domain-containing protein 12 measurement	DCAF1 CELSR3 CDHR4	1.96e-04	39	85	3	EFO_0008298
Disease	5-hydroxylysine measurement	SLC7A9 PSMA4	2.27e-04	8	85	2	EFO_0800002
Disease	ursodeoxycholate measurement	FKBP15 RASEF	2.27e-04	8	85	2	EFO_0010547
Disease	mean corpuscular hemoglobin concentration	DPY19L3 CTDSPL2 ATAD2B BEND3 CACNA1I EIF2AK4 MYO15A PIBF1 ITGB5 IGDCC4 XPO7	3.27e-04	1105	85	11	EFO_0004528
Disease	Thyroid Diseases	DIO1 ITGB5	6.27e-04	13	85	2	C0040128
Disease	response to supplemental oxygen	FSTL4 ASTN2	1.36e-03	19	85	2	EFO_0009796
Disease	Joubert syndrome 1	AHI1 PIBF1	1.66e-03	21	85	2	C4551568
Disease	Autism Spectrum Disorders	DLX1 USH2A UPP2	1.92e-03	85	85	3	C1510586
Disease	migraine disorder, diastolic blood pressure	ASTN2 ITGB5	2.36e-03	25	85	2	EFO_0006336, MONDO_0005277
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MSH6 ATM	2.55e-03	26	85	2	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	MSH6 ATM	2.75e-03	27	85	2	C1112155

Protein segments in the cluster

Peptide	Gene	Start	Entry
NYLTNRYPNLVLILE	TMEM184C	131	Q9NVA4
RLLLTQEQRYVYAQV	BEST4	51	Q8NFU0
VYSRPQLLRQQELYA	BAHCC1	921	Q9P281
LNSLTYQVLDVQRYP	B4GALT1	371	P15291
VTRPEQLLLQSYFQA	C1orf167	1016	Q5SNV9
ERYTEQVTPLLVYAQ	CFAP54	1776	Q96N23
FLNALQSPIEYQRRE	ARHGEF25	471	Q86VW2
EPREFLQQQYRLFQT	BUB1	131	O43683
LFQDVIYQVYVRLRP	CTDSPL2	316	Q05D32
IYEIIQEFPALQERN	EIF2AK4	1181	Q9P2K8
EEQIVFNENFPYLLR	AHI1	421	Q8N157
QQELVRSILEPNFRY	GSDMC	426	Q9BYG8
VLYRLQFNEFVNTVP	ARL4A	36	P40617
LVRFYQRFPEEIQQQ	AP3S2	16	P59780
VLNRQNVPFEDYTRL	CEP83	601	Q9Y592
RFQQTQYLALPERAE	DLX1	146	P56177
QEVFLSILYRVLPIQ	DPY19L3	136	Q6ZPD9
GPLDYEQQRLYRLTV	CDHR4	501	A6H8M9
EINRVVPLYTLIQDN	ASTN2	1006	O75129
QYELTQLVPGRLYEV	IGDCC4	701	Q8TDY8
FIPREEQVSTLYQNI	RASEF	141	Q8IZ41
QRLQIIRNYTEIYFP	BEND3	446	Q5T5X7
QERTYQRLLLENPRF	ARHGEF19	476	Q8IW93
YYSLLQENLPLERRN	CCNG1	161	P51959
QTVTQVFRLRPYQDV	DEPDC5	71	O75140
ELVVQLRPIFQAYVT	MUC6	506	Q6W4X9
APTFQQQEYSVLLRE	DCHS1	1646	Q96JQ0
EQRLILQYLTPLGEY	DCAF1	326	Q9Y4B6
PIIYAFRNQEIQRAL	GPR6	326	P46095
LLRYLQEQNRPYSSQ	PSMC3IP	16	Q9P2W1
TVVLLFQNRVPELSY	SLC2A7	366	Q6PXP3
VREVQEYIPAQLYRT	MYO15A	3361	Q9UKN7
LEQQFTQLLVPYLRS	IMPG1	601	Q17R60
RIQYEEVLYIQRPIE	ATAD2B	886	Q9ULI0
ILFQEFRQRYEILTP	MYH14	736	Q7Z406
RVFVNQLYQPSLERE	PTGER4	291	P35408
AREYRILLYISQQQP	FKBP15	106	Q5T1M5
QTALLRYVLEQPYSR	MED23	266	Q9ULK4
ITVLIYPNSIQEYIR	LAPTM4B	211	Q86VI4
SRLPEIYIQLQREYQ	EHD4	336	Q9H223
RYQLEIPENFTTRNL	MSH6	976	P52701
FQLQVRQVEDYPVDL	ITGB5	126	P18084
INLFVVDRNDNYPVI	PCDHAC1	541	Q9H158
RYEQLQNETRQTPEY	ACP2	161	P11117
SQLYAALPERLYIIQ	DIO1	206	P49895
RDVIYTLIHYINQRP	ATM	1466	Q13315
RIQRYQDLQLDYSLT	DOCK9	1091	Q9BZ29
YRNQLLNIFVRPSLV	GNPAT	481	O15228
EYYNTPARIIVILQE	DNAH17	326	Q9UFH2
IIELNQQTAPVRYFL	GPRC5D	81	Q9NZD1
NQLNYITEELRNPYR	SLC7A9	236	P82251
RNPYNIFDSIIVIIS	CACNA1I	701	Q9P0X4
NRYIYVAQPALSRVL	FSTL4	511	Q6MZW2
FRYPLTISQLQIEEF	CA8	236	P35219
QQVDRIILQLNRYYP	CARD19	26	Q96LW7
INPIIYTVFNEEFRQ	HTR1D	351	P28221
YQPQLDQQTLIRYIC	C1orf100	66	Q5SVJ3
QLYFTEPQQLLDVFR	CFAP100	381	Q494V2
QVSLVINYDLPTNRE	EIF4A2	341	Q14240
YQVDPRSARFQELLQ	GADD45GIP1	166	Q8TAE8
PEELYQTFQRIVENV	EEF2	171	P13639
RRQEQSVYYLPIFIV	CDH7	551	Q9ULB5
VFQILYRNEEVPIND	FAM135B	71	Q49AJ0
PVFEQAQYRETLREN	CELSR3	431	Q9NYQ7
RLIAQRYLLQYQEPI	PSMA4	91	P25789
LYYLQIHPQELRQIS	DDB1	516	Q16531
PSQREVFLQQIYEQL	SZT2	176	Q5T011
LENLTPFTQYEIRIQ	USH2A	3831	O75445
EYQQRPQLLISNFIR	UPP2	296	O95045
FIPLLRERIYSNNQY	VAC14	176	Q08AM6
YTVPQEQRYIIRLLL	TMEM184A	81	Q6ZMB5
NFRNILETVYPDSIQ	PRAMEF22	196	A3QJZ6
VLQTLPEENYQVLRF	ARHGAP1	356	Q07960
LAIRRQYQSIVPALY	WDR17	1171	Q8IZU2
QNYVRFIEDELQIPV	ADSS2	426	P30520
DYLQQEVPRAFVNLV	PLB1	201	Q6P1J6
SQINLREYPNLVTIY	SP110	86	Q9HB58
VTENYVIFLEQPFRL	BCO1	241	Q9HAY6
ETERQRIQQLAFVYP	PPM1M	256	Q96MI6
VQRIPQYRLLLTDYL	FGD6	1016	Q6ZV73
QTQQPYRYLIESVRQ	PIBF1	621	Q8WXW3
QYEQYLQEEILITRQ	SEPTIN12	136	Q8IYM1
SIPYQLQRLFVLLQT	USP47	231	Q96K76
ILGRRAEQLPQIYYI	ZPBP	276	Q9BS86
NYPEVIRLIANFTVT	XPO7	351	Q9UIA9
YYLEQRNDIIRNIPG	TSPYL6	236	Q8N831
PVVYIFQLDARRQQL	WDR4	266	P57081
IRIPYLQQVQLYDES	XRRA1	266	Q6P2D8
EYRLPFTINNLTINI	VPS37A	51	Q8NEZ2