Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	1.62e-05	3	47	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	3.24e-05	4	47	2	GO:0102391
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO3 FMO6P	8.09e-05	6	47	2	GO:0004499
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	FMO3 MICAL3 FMO6P	1.14e-04	40	47	3	GO:0016709
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	1.50e-04	8	47	2	GO:0004321
GeneOntologyMolecularFunction	phosphatidyl phospholipase B activity	PNPLA6 PNPLA7	2.94e-04	11	47	2	GO:0102545
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	2.94e-04	11	47	2	GO:0031956
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	1.11e-03	21	47	2	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	1.70e-03	26	47	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	1.83e-03	27	47	2	GO:0016405
GeneOntologyMolecularFunction	lysophospholipase activity	PNPLA6 PNPLA7	2.11e-03	29	47	2	GO:0004622
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	2.41e-03	31	47	2	GO:0016878
GeneOntologyMolecularFunction	monooxygenase activity	FMO3 MICAL3 FMO6P	2.51e-03	115	47	3	GO:0004497
Domain	UPF0028	PNPLA6 PNPLA7	5.93e-06	2	46	2	PS01237
Domain	Patatin/PLipase_A2-rel	PNPLA6 PNPLA7	2.11e-04	9	46	2	IPR002641
Domain	PNPLA	PNPLA6 PNPLA7	2.11e-04	9	46	2	PS51635
Domain	Patatin	PNPLA6 PNPLA7	2.11e-04	9	46	2	PF01734
Domain	Frizzled	FZD10 SMO	3.22e-04	11	46	2	IPR000539
Domain	Frizzled	FZD10 SMO	3.22e-04	11	46	2	PF01534
Domain	Frizzled	FZD10 SMO	3.22e-04	11	46	2	SM01330
Domain	Frizzled/SFRP	FZD10 SMO	6.97e-04	16	46	2	IPR015526
Domain	Acyl_Trfase/lysoPLipase	PNPLA6 PNPLA7	7.88e-04	17	46	2	IPR016035
Domain	AMP-bd_C	ACSM2A ACSM2B	7.88e-04	17	46	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	7.88e-04	17	46	2	PF13193
Domain	FRI	FZD10 SMO	1.10e-03	20	46	2	SM00063
Domain	-	FZD10 SMO	1.21e-03	21	46	2	1.10.2000.10
Domain	Frizzled_dom	FZD10 SMO	1.58e-03	24	46	2	IPR020067
Domain	FZ	FZD10 SMO	1.58e-03	24	46	2	PS50038
Domain	Fz	FZD10 SMO	1.58e-03	24	46	2	PF01392
Domain	AMP-binding_CS	ACSM2A ACSM2B	1.86e-03	26	46	2	IPR020845
Domain	AMP_BINDING	ACSM2A ACSM2B	2.15e-03	28	46	2	PS00455
Domain	AMP-binding	ACSM2A ACSM2B	2.47e-03	30	46	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	2.47e-03	30	46	2	IPR000873
Domain	CNMP_BINDING_1	PNPLA6 PNPLA7	2.81e-03	32	46	2	PS00888
Domain	CNMP_BINDING_2	PNPLA6 PNPLA7	2.81e-03	32	46	2	PS00889
Domain	cNMP	PNPLA6 PNPLA7	3.17e-03	34	46	2	SM00100
Domain	cNMP_binding	PNPLA6 PNPLA7	3.17e-03	34	46	2	PF00027
Domain	cNMP-bd_dom	PNPLA6 PNPLA7	3.35e-03	35	46	2	IPR000595
Domain	CNMP_BINDING_3	PNPLA6 PNPLA7	3.35e-03	35	46	2	PS50042
Domain	cNMP-bd-like	PNPLA6 PNPLA7	3.94e-03	38	46	2	IPR018490
Domain	-	PNPLA6 PNPLA7	6.23e-03	48	46	2	2.60.120.10
Domain	RmlC-like_jellyroll	PNPLA6 PNPLA7	7.01e-03	51	46	2	IPR014710
Domain	-	FMO3 MICAL3	8.40e-03	56	46	2	3.50.50.60
Domain	FAD/NAD-binding_dom	FMO3 MICAL3	8.69e-03	57	46	2	IPR023753
Domain	GPCR_2-like	FZD10 SMO	9.59e-03	60	46	2	IPR017981
Domain	GPCR_2_secretin-like	FZD10 SMO	9.59e-03	60	46	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	FZD10 SMO	9.90e-03	61	46	2	PS50261
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	9.45e-05	6	36	2	MM14693
Pathway	REACTOME_GLYCEROPHOSPHOLIPID_CATABOLISM	PNPLA6 PNPLA7	1.32e-04	7	36	2	M27657
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	1.32e-04	7	36	2	MM14598
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	2.26e-04	9	36	2	M26968
Pathway	REACTOME_BBSOME_MEDIATED_CARGO_TARGETING_TO_CILIUM	MCHR1 SMO	4.86e-04	13	36	2	MM15210
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	1.94e-06	2	49	2	19634011
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	1.94e-06	2	49	2	16521160
Pubmed	Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.	PNPLA6 PNPLA7	1.94e-06	2	49	2	12640454
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	1.94e-06	2	49	2	29948332
Pubmed	Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase.	PNPLA6 PNPLA7	1.94e-06	2	49	2	18086666
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	CEP170 ARVCF MICAL3 DNMT3A	2.50e-06	67	49	4	29254152
Pubmed	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.	FMO3 FMO6P	5.83e-06	3	49	2	28413702
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	1.16e-05	4	49	2	32830538
Pubmed	Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.	SLC6A3 SMO	1.94e-05	5	49	2	22841315
Pubmed	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.	SLC6A3 SMO	2.91e-05	6	49	2	34552196
Pubmed	Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.	FMO3 FMO6P	2.91e-05	6	49	2	12527699
Pubmed	Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2.	SHISA2 SMO	4.07e-05	7	49	2	28885142
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ADAMTSL1 NXPE4 DHRS7 CLEC1B CPXM1 FGFRL1 SHISA2 LRRTM3	6.48e-05	985	49	8	12975309
Pubmed	Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.	PNPLA6 PNPLA7	6.96e-05	9	49	2	19029121
Pubmed	Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.	FMO3 FMO6P	6.96e-05	9	49	2	22903471
Pubmed	Characterization of the human patatin-like phospholipase family.	PNPLA6 PNPLA7	8.69e-05	10	49	2	16799181
Pubmed	Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.	XYLT1 SMO	1.75e-04	14	49	2	19666503
Pubmed	Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.	FZD10 SMO	2.93e-04	18	49	2	30352852
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DOCK4 MAST2 ZBED1	3.97e-04	101	49	3	9872452
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	ADAMTSL1 CLEC1B FGFRL1 SHISA2 LRRTM3	4.68e-04	460	49	5	20562862
Pubmed	ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.	MCHR1 SMO	5.26e-04	24	49	2	24797473
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	ACSM2A ACSM2B	5.71e-04	25	49	2	19372376
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	MCHR1 SMO	5.71e-04	25	49	2	28154160
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	CEP170 FMO3 CELA2A SLC19A2 MAST2 FMO6P EPHA8	5.71e-04	1031	49	7	16710414
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	SLC6A3 ARVCF LRRTM3	6.73e-04	121	49	3	31900314
Pubmed	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	DOCK4 SMO	8.25e-04	30	49	2	19401682
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MAN2A2 PNPLA6 ARVCF PIEZO1 FGFRL1 MICAL3 MAST2	8.59e-04	1105	49	7	35748872
Pubmed	miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.	SLC6A3 DNMT3A	8.81e-04	31	49	2	37816598
Pubmed	A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver.	DHRS7 SLC37A4	1.12e-03	35	49	2	28597972
Interaction	ACSM2A interactions	ACSM2A ACSM2B	3.32e-05	4	48	2	int:ACSM2A
Interaction	ACSM2B interactions	ACSM2A ACSM2B	3.32e-05	4	48	2	int:ACSM2B
Cytoband	16p12.3	XYLT1 ACSM2A ACSM2B	6.68e-06	34	49	3	16p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	FMO3 SLC19A2 STYXL2 FMO6P	1.14e-05	129	49	4	chr1q24
Cytoband	1q24.3	FMO3 FMO6P	2.09e-04	20	49	2	1q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	XYLT1 ACSM2A ACSM2B	8.39e-04	172	49	3	chr16p12
Cytoband	16q24.3	CTU2 PIEZO1	1.43e-03	52	49	2	16q24.3
GeneFamily	Patatin like phospholipase domain containing	PNPLA6 PNPLA7	1.53e-04	10	34	2	466
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD10 SMO	1.87e-04	11	34	2	286
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	1.08e-03	26	34	2	40
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	XYLT1 CLEC1B PRMT2 ACSM2B DNMT3A	6.97e-07	152	49	5	aa88084ba1851d879ece82baa516f6b46cbd2eb8
Disease	X-21319 measurement	ACSM2A ACSM2B	2.38e-06	2	46	2	EFO_0800807
Disease	S-methylcysteine measurement	FMO3 FMO6P	2.38e-06	2	46	2	EFO_0800054
Disease	X-11478 measurement	ACSM2A ACSM2B	7.13e-06	3	46	2	EFO_0021242
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	2.37e-05	5	46	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	3.55e-05	6	46	2	EFO_0800106
Disease	blindness (implicated_via_orthology)	PNPLA6 PNPLA7	6.62e-05	8	46	2	DOID:1432 (implicated_via_orthology)
Disease	cerebellar ataxia (implicated_via_orthology)	PNPLA6 PNPLA7	6.62e-05	8	46	2	DOID:0050753 (implicated_via_orthology)
Disease	lentiform nucleus measurement	FMO3 FMO6P	2.14e-04	14	46	2	EFO_0004913
Disease	serum metabolite measurement	CHMP7 ADAMTSL1 FMO3 ACSM2A FMO6P GOT2 ACSM2B	6.08e-04	945	46	7	EFO_0005653
Disease	susceptibility to rheumatic fever measurement	XYLT1 KCNB2	8.76e-04	28	46	2	EFO_0008416
Disease	Ovarian Mucinous Adenocarcinoma	MAP3K14 MAST2	1.07e-03	31	46	2	C1335167

Protein segments in the cluster

Peptide	Gene	Start	Entry
MCSGWSSSVIWRHTQ	CEP295NL	1	Q96MC4
SSSGSKRWVSQWASL	CEP170	576	Q5SW79
WRRHMSVALSWAVTS	PRMT2	401	P55345
SAGNWMWATYIRATV	ARVCF	691	O00192
VSWWMTGRSRAAEGT	DNMT3A	311	Q9Y6K1
LQASDIMWTISDTGW	ACSM2A	251	Q08AH3
DSRTWWGSRNHSSGM	CPXM1	211	Q96SM3
CSSSAWWGSSVKTSM	CELA2A	186	P08217
WELTDMVVWVTGASS	DHRS7	46	Q9Y394
MTARAWASWRSSALL	CD300C	1	Q08708
SMVATVSSEWAWEVG	APLNR	186	P35414
ETWMWDLVSVSSSGS	OVOS1	626	Q6IE37
TRTVEWLNMRSWCSG	PNPLA6	916	Q8IY17
SAWMVRSWSLGTSPL	MICAL3	421	Q7RTP6
MISSRSGSWVMSRVW	FMO3	211	P31513
MATSTSTEAKSASWW	HPS4	1	Q9NQG7
PSRWMVTSWSACTRS	ADAMTSL1	1546	Q8N6G6
TMWTKDGRTIHSGWS	FGFRL1	61	Q8N441
WMLKASPWATGTLST	MUC3A	11	Q02505
VPSSVTTMLSWVSFW	GABRE	286	P78334
IISTRSASWVMSRVW	FMO6P	211	O60774
TWMWDLVSVDSSGSA	OVOS2	726	Q6IE36
TASAMRVHTDGSLWW	PNPLA7	1041	Q6ZV29
ITSGMWIWTSKTLQS	FZD10	516	Q9ULW2
TWWAILSTSMNLAGG	SLC37A4	136	O43826
TSIPASFWWATITMT	KCNB2	366	Q92953
ITEMTSTLRDWGTMW	DOCK4	86	Q8N1I0
SGWQMCSWKSSVSSA	C7orf61	121	Q8IZ16
MASVDSSWISWGVGV	CHMP7	111	Q8WUX9
SSASDVWSFGVVMWE	EPHA8	816	P29322
VTALFVTSWLMSGTW	DPY19L4	176	Q7Z388
MWRQTWDSDSSTDIF	MAN2A2	331	P49641
PSSTSGKLSMWSWKS	MAST2	1646	Q6P0Q8
SSARLWEQATGTGWM	MCHR1	56	Q99705
ISWSTWGEMTLSLFS	SLC19A2	356	O60779
LLAWSGGPSSSSMVW	CTU2	76	Q2VPK5
WSSQAEARSSSWNMV	MAP3K14	831	Q99558
ISVIGQTMSWTWSSL	LRRTM3	241	Q86VH5
MTSTIPSGHVWRNTW	NXPE4	311	Q6UWF7
MWGARRSSVSSSWNA	SHISA2	1	Q6UWI4
SARASSWWTHVEMGP	GOT2	26	P00505
LQASDIMWTISDTGW	ACSM2B	251	Q68CK6
SVGSASSSWWRVMAL	CLEC1B	21	Q9P126
WRMATIWGGASLLST	XYLT1	386	Q86Y38
MAAGWLTTWSQNSVT	ZNF177	1	Q13360
RRADSMSSESTWDAW	STYXL2	466	Q5VZP5
WANALGWVIATSSMA	SLC6A3	556	Q01959
FGTGIAMSTWVWTKA	SMO	526	Q99835
SSASDVWMFGVTLWE	TNK1	301	Q13470
VMDWVWTDTTLSLSS	PIEZO1	2121	Q92508
LVSNRVSWWGSTLAM	ZBED1	346	O96006