Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	ACAD11 MAOB ACOX3 GSR	5.41e-05	94	44	4	GO:0050660
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NCOA6 RARB GRM1 BCAS3 MEF2A TP53BP2	2.89e-04	417	44	6	GO:0061629
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN1 NLGN4X	5.58e-04	16	44	2	GO:0042043
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA6 RARB GRM1 BCAS3	7.55e-04	187	44	4	GO:0016922
GeneOntologyMolecularFunction	kinase binding	SPG11 ACVR1 RARA RAD54L2 PTPRF CEACAM20 MEF2A POLR2A	1.12e-03	969	44	8	GO:0019900
GeneOntologyMolecularFunction	nuclear retinoid X receptor binding	NCOA6 RARB	1.17e-03	23	44	2	GO:0046965
GeneOntologyMolecularFunction	transcription factor binding	NCOA6 RARA RARB GRM1 BCAS3 MEF2A TP53BP2	1.20e-03	753	44	7	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NCOA6 RARB GRM1 BCAS3 MEF2A TP53BP2	1.64e-03	582	44	6	GO:0140297
GeneOntologyMolecularFunction	histone acetyltransferase binding	BCAS3 MEF2A	1.86e-03	29	44	2	GO:0035035
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell differentiation	RARA RARB MEF2A	7.99e-06	19	43	3	GO:0055012
GeneOntologyBiologicalProcess	postsynapse assembly	DOCK1 NLGN1 NLGN4X NUMBL	4.18e-05	93	43	4	GO:0099068
GeneOntologyBiologicalProcess	behavior	ZFHX2 SPG11 NLGN1 NLGN4X GRM1 SOBP CRBN PHF21A NPAS2	7.54e-05	891	43	9	GO:0007610
Domain	Retinoic_acid_rcpt	RARA RARB	3.24e-05	4	44	2	IPR003078
Domain	Nlgn	NLGN1 NLGN4X	5.40e-05	5	44	2	IPR000460
Domain	Acyl-CoA_dh_1	ACAD11 ACOX3	4.16e-04	13	44	2	PF00441
Domain	Carboxylesterase_B_CS	NLGN1 NLGN4X	4.16e-04	13	44	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN1 NLGN4X	4.85e-04	14	44	2	PS00941
Domain	COesterase	NLGN1 NLGN4X	4.85e-04	14	44	2	PF00135
Domain	CarbesteraseB	NLGN1 NLGN4X	4.85e-04	14	44	2	IPR002018
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACAD11 ACOX3	5.59e-04	15	44	2	IPR006091
Domain	Acyl-CoA_dh_M	ACAD11 ACOX3	5.59e-04	15	44	2	PF02770
Domain	AcylCoA_DH/oxidase_NM_dom	ACAD11 ACOX3	5.59e-04	15	44	2	IPR009100
Domain	AcylCo_DH/oxidase_C	ACAD11 ACOX3	6.37e-04	16	44	2	IPR009075
Domain	zf-C4	RARA RARB	5.26e-03	46	44	2	PF00105
Domain	Znf_hrmn_rcpt	RARA RARB	5.26e-03	46	44	2	IPR001628
Domain	Nuclear_hrmn_rcpt	RARA RARB	5.26e-03	46	44	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	RARA RARB	5.26e-03	46	44	2	PS51030
Domain	NUCLEAR_REC_DBD_1	RARA RARB	5.26e-03	46	44	2	PS00031
Domain	ZnF_C4	RARA RARB	5.26e-03	46	44	2	SM00399
Domain	-	RARA RARB	5.48e-03	47	44	2	1.10.565.10
Domain	HOLI	RARA RARB	5.71e-03	48	44	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	RARA RARB	5.71e-03	48	44	2	IPR000536
Domain	Hormone_recep	RARA RARB	5.71e-03	48	44	2	PF00104
Domain	-	MAOB GSR	7.71e-03	56	44	2	3.50.50.60
Domain	-	RARA RARB	7.97e-03	57	44	2	3.30.50.10
Domain	FAD/NAD-binding_dom	MAOB GSR	7.97e-03	57	44	2	IPR023753
Domain	Znf_NHR/GATA	RARA RARB	8.25e-03	58	44	2	IPR013088
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN1 NLGN4X GRM1 PTPRF	1.94e-05	67	34	4	MM15327
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN1 NLGN4X GRM1 PTPRF	5.45e-05	87	34	4	M27617
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NLGN1 NLGN4X GRM1	6.06e-05	32	34	3	MM15326
Pathway	WP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV	NLGN1 NLGN4X GRM1	6.66e-05	33	34	3	M39875
Pathway	WP_VITAMIN_A1_AND_A5X_PATHWAYS	RARA RARB	8.42e-05	6	34	2	M48097
Pathway	REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS	NCOA6 RARA RARB POLR2A	2.03e-04	122	34	4	M29689
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NLGN1 NLGN4X GRM1	3.26e-04	56	34	3	M27616
Pubmed	PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.	RARA RARB POLR2A	3.32e-07	11	45	3	15808511
Pubmed	Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm.	ACVR1 RARA RARB	5.74e-07	13	45	3	19165826
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	LHB NLGN1 NLGN4X MAOB	1.56e-06	65	45	4	19598235
Pubmed	Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.	RARA RARB	1.64e-06	2	45	2	29921692
Pubmed	Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.	RARA RARB	1.64e-06	2	45	2	24833708
Pubmed	Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation.	RARA RARB	1.64e-06	2	45	2	15159591
Pubmed	[The significance of expression of isoforms RARa1 and RARa2 in response to medicinal therapy and in evaluation of total survival of patients with primarily detected multiple myeloma].	RARA RARB	1.64e-06	2	45	2	30601638
Pubmed	Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.	RARA RARB	1.64e-06	2	45	2	7644503
Pubmed	Retinoic acid receptors in normal growth and development.	RARA RARB	1.64e-06	2	45	2	1330302
Pubmed	Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non-small cell lung cancer.	RARA RARB	1.64e-06	2	45	2	27306217
Pubmed	Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations.	RARA RARB	1.64e-06	2	45	2	9168777
Pubmed	Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells.	RARA RARB	1.64e-06	2	45	2	12009305
Pubmed	Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells.	RARA RARB	1.64e-06	2	45	2	1334013
Pubmed	Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.	RARA RARB	4.91e-06	3	45	2	9852056
Pubmed	Differential expression of retinoic acid receptors in normal and malignant esophageal tissues.	RARA RARB	4.91e-06	3	45	2	15255287
Pubmed	Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.	RARA RARB	4.91e-06	3	45	2	7607068
Pubmed	Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.	RARA RARB	4.91e-06	3	45	2	7607067
Pubmed	Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.	RARA RARB	4.91e-06	3	45	2	17244680
Pubmed	Impaired distribution of retinoic acid receptors in the hindgut-tailgut region of murine embryos with anorectal malformations.	RARA RARB	4.91e-06	3	45	2	11172439
Pubmed	Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1.	RARA RARB	4.91e-06	3	45	2	8383767
Pubmed	The molecular and genetic dissection of the retinoid signalling pathway.	RARA RARB	4.91e-06	3	45	2	8276261
Pubmed	Retinoic acid receptor gamma: specific immunodetection and phosphorylation.	RARA RARB	4.91e-06	3	45	2	1655807
Pubmed	Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural differentiation of PCC7 cells.	RARA RARB	4.91e-06	3	45	2	15831518
Pubmed	A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.	RARA RARB	4.91e-06	3	45	2	17252005
Pubmed	Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus.	RARA RARB	4.91e-06	3	45	2	8136307
Pubmed	Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation.	RARA RARB	4.91e-06	3	45	2	8626453
Pubmed	Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts.	RARA RARB	4.91e-06	3	45	2	24357724
Pubmed	Function of retinoic acid receptor gamma in the mouse.	RARA RARB	4.91e-06	3	45	2	8388780
Pubmed	Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart.	RARA RARB	4.91e-06	3	45	2	9659935
Pubmed	Retinoids and vertebrate development.	RARA RARB	4.91e-06	3	45	2	7910825
Pubmed	Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo.	RARA RARB	4.91e-06	3	45	2	10842077
Pubmed	Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development.	RARA RARB	4.91e-06	3	45	2	8027572
Pubmed	Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.	RARA RARB	4.91e-06	3	45	2	11245412
Pubmed	mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.	RARA RARB	4.91e-06	3	45	2	23969901
Pubmed	Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.	RARA RARB	4.91e-06	3	45	2	2544807
Pubmed	[Genetic expression and morphogenesis of the skin in vertebrates].	RARA RARB	4.91e-06	3	45	2	8099268
Pubmed	Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells.	RARA RARB	4.91e-06	3	45	2	12000751
Pubmed	Altered expression of retinoic acid (RA) receptor mRNAs in the fetal mouse secondary palate by all-trans and 13-cis RAs: implications for RA-induced teratogenesis.	RARA RARB	4.91e-06	3	45	2	10100049
Pubmed	Specificity of retinoid receptor gene expression in mouse cervical epithelia.	RARA RARB	4.91e-06	3	45	2	8156902
Pubmed	Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia.	RARA RARB	4.91e-06	3	45	2	9699718
Pubmed	Mammalian hexokinase 1: evolutionary conservation and structure to function analysis.	RARA RARB	4.91e-06	3	45	2	1783373
Pubmed	Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues.	RARA RARB	4.91e-06	3	45	2	1283441
Pubmed	Characterization of retinoic acid receptor-deficient keratinocytes.	RARA RARB	4.91e-06	3	45	2	10748128
Pubmed	Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs.	RARA RARB	4.91e-06	3	45	2	36446525
Pubmed	Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse.	RARA RARB	4.91e-06	3	45	2	2737701
Pubmed	Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.	RARA RARB	4.91e-06	3	45	2	15528208
Pubmed	Immunohistochemical localization of the retinoic Acid receptors in human prostate.	RARA RARB	4.91e-06	3	45	2	12399530
Pubmed	Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.	RARA RARB	4.91e-06	3	45	2	29848550
Pubmed	Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.	SCAF8 POLR2A	4.91e-06	3	45	2	18550522
Pubmed	Association of retinoic acid receptor genes with meningomyelocele.	RARA RARB	4.91e-06	3	45	2	21254357
Pubmed	Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.	RARA RARB	4.91e-06	3	45	2	1655630
Pubmed	HACE1: A novel repressor of RAR transcriptional activity.	RARA RARB	9.81e-06	4	45	2	19350571
Pubmed	Association of peroxisome proliferator-activated receptors/retinoic acid receptors with renal diseases.	RARA RARB	9.81e-06	4	45	2	24050824
Pubmed	Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.	RARA RARB	9.81e-06	4	45	2	12093741
Pubmed	Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton.	RARA RARB	9.81e-06	4	45	2	7626396
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN1 NLGN4X	9.81e-06	4	45	2	16077734
Pubmed	Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.	RARA RARB	9.81e-06	4	45	2	8524212
Pubmed	Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.	RARA RARB	9.81e-06	4	45	2	17363914
Pubmed	Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.	RARA RARB	9.81e-06	4	45	2	22022577
Pubmed	The retinoid receptors.	RARA RARB	9.81e-06	4	45	2	7967725
Pubmed	Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.	RARA RARB	9.81e-06	4	45	2	9005841
Pubmed	Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter.	RARA RARB	9.81e-06	4	45	2	14691372
Pubmed	Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.	RARA RARB	9.81e-06	4	45	2	18845237
Pubmed	The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.	RARA RARB	9.81e-06	4	45	2	12464434
Pubmed	Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.	RARA RARB	9.81e-06	4	45	2	9376317
Pubmed	Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.	RARA RARB	9.81e-06	4	45	2	23102699
Pubmed	Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.	RARA RARB	9.81e-06	4	45	2	9348290
Pubmed	Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.	RARA RARB	9.81e-06	4	45	2	2556642
Pubmed	Retinoic acid signalling in the development of branchial arches.	RARA RARB	9.81e-06	4	45	2	15380252
Pubmed	Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.	RARA RARB	9.81e-06	4	45	2	10869350
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SFXN1 DOCK1 ZFHX2 NUMBL SOBP SCAF8 BCAS3 MEF2A XPNPEP3 NPAS2	1.63e-05	1489	45	10	28611215
Pubmed	Retinoic acid signaling regulates murine bronchial tubule formation.	RARA RARB	1.63e-05	5	45	2	12834868
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN1 NLGN4X	1.63e-05	5	45	2	15620359
Pubmed	Retinoic acid signaling is necessary for the development of the organ of Corti.	RARA RARB	1.63e-05	5	45	2	10452855
Pubmed	An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.	RARA RARB	1.63e-05	5	45	2	19665987
Pubmed	Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.	RARA RARB	1.63e-05	5	45	2	31097581
Pubmed	Regulation of the Oct-4 gene by nuclear receptors.	RARA RARB	1.63e-05	5	45	2	8152920
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN1 NLGN4X	1.63e-05	5	45	2	10996085
Pubmed	Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos.	RARA RARB	1.63e-05	5	45	2	1334737
Pubmed	Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.	RARA RARB	1.63e-05	5	45	2	9053308
Pubmed	Vitamin A controls epithelial/mesenchymal interactions through Ret expression.	RARA RARB	1.63e-05	5	45	2	11138002
Pubmed	High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.	RARA RARB	1.63e-05	5	45	2	8394014
Pubmed	Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.	RARA NPAS2	1.63e-05	5	45	2	11439184
Pubmed	Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis.	RARA RARB	1.63e-05	5	45	2	9097025
Pubmed	Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice.	RARA RARB	1.63e-05	5	45	2	8681798
Pubmed	Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos.	RARA RARB	1.63e-05	5	45	2	8174226
Pubmed	Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.	RARA RARB	1.63e-05	5	45	2	19006694
Pubmed	ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.	RARA RARB	1.63e-05	5	45	2	19345331
Pubmed	Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.	RARA RARB	1.63e-05	5	45	2	12195422
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN1 NLGN4X	1.63e-05	5	45	2	37865312
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NCOA6 DNAH9 PHF21A AHNAK2	1.98e-05	123	45	4	26912792
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN1 NLGN4X	2.45e-05	6	45	2	21838267
Pubmed	The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.	RARA RARB	2.45e-05	6	45	2	9806918
Pubmed	Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis.	RARA RARB	2.45e-05	6	45	2	1966045
Pubmed	Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.	RARA RARB	2.45e-05	6	45	2	11328745
Pubmed	A genetic dissection of the retinoid signalling pathway in the mouse.	RARA RARB	2.45e-05	6	45	2	10604193
Pubmed	Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord.	RARA RARB	2.45e-05	6	45	2	8563020
Pubmed	Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos.	RARA RARB	2.45e-05	6	45	2	1849812
Pubmed	The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.	RARA RARB	2.45e-05	6	45	2	9153406
Pubmed	Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse.	RARA RARB	2.45e-05	6	45	2	9590554
Interaction	RXRA interactions	NCOA6 ACVR1 RARA RARB RAD54L2 POLR2A NPAS2	7.60e-08	169	44	7	int:RXRA
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	ATP5ME PIGG ACOX3	1.36e-03	222	45	3	chr4p16
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	NHSL1 GRM1	2.69e-03	78	45	2	chr6q24
Cytoband	4p16.3	ATP5ME PIGG	3.18e-03	85	45	2	4p16.3
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	MYO15B PTPRF MAOB NPAS2	1.76e-05	154	45	4	8a643d91896af9b630a715fb284c1523d01ad1a3
ToppCell	droplet-Liver-Hepatocytes-21m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAD11 PTPRF MAOB NPAS2	2.26e-05	164	45	4	90afae3cca108ebfb44ff2ec4adcbb8c68a0bdf2
ToppCell	Int-URO-Lymphocyte-T_NK-dnT\|Int-URO / Disease, Lineage and Cell Type	ACAD11 PTPRF NUMBL BCAS3	2.72e-05	172	45	4	e70299573da1679d6d286c3a43699cbff76e207d
ToppCell	E18.5-samps\|World / Age Group, Lineage, Cell class and subclass	TINAG PTPRF MAOB NPAS2	3.39e-05	182	45	4	9649f15858d1ede73e068afc59df3ac367b49687
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHB TINAG PTPRF DNAH9	4.01e-05	190	45	4	edc0a0eb17abbecb0f06d302be3d4f8c1dd4f333
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-dn_T\|Int-URO / Disease, condition lineage and cell class	ACAD11 PTPRF NUMBL BCAS3	4.89e-05	200	45	4	020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NLGN1 ACAD11 MAOB NUMBL	4.89e-05	200	45	4	4c3c11dd5e71ebc3d62264eeaeb71a850b149779
Drug	Procyclidine hydrochloride [1508-76-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A	RARA RAD54L2 GRM1 MAOB XPNPEP3 AHNAK2	2.25e-06	195	45	6	4817_UP
Drug	Ro 8-8717	RARA RARB	3.82e-06	2	45	2	CID006438148
Drug	Tamibarotene	RARA RARB	3.82e-06	2	45	2	DB04942
Drug	SRI 5898-21	RARA RARB	2.29e-05	4	45	2	CID006439757
Drug	Tazarotene	RARA RARB	2.29e-05	4	45	2	DB00799
Drug	Water Pollutants, Chemical	LHB ATP5ME DDX59 ACVR1 RAD54L2 ACAD11 GSR NPAS2	3.04e-05	635	45	8	ctd:D014874
Drug	Cd2366	RARA RARB	3.81e-05	5	45	2	CID006443796
Drug	Fusaric acid [536-69-6]; Up 200; 22.4uM; MCF7; HT_HG-U133A	SFXN1 DOCK1 RARA RAD54L2 POLR2A	3.95e-05	194	45	5	3245_UP
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A	DOCK1 RARA RARB RAD54L2 MEF2A	4.25e-05	197	45	5	5692_DN
Drug	clozapine; Down 200; 10uM; MCF7; HT_HG-U133A	ZFHX2 RARA RAD54L2 GLB1L AHNAK2	4.25e-05	197	45	5	5589_DN
Drug	Alfadolone acetate [23930-37-2]; Down 200; 10.2uM; PC3; HT_HG-U133A	RAD54L2 SOBP BCAS3 ACOX3 XPNPEP3	4.46e-05	199	45	5	7262_DN
Drug	trans-retinol acetate	NCOA6 RARA RARB	4.92e-05	36	45	3	CID000005057
Drug	Monocrotophos	LHB MAOB GSR	5.35e-05	37	45	3	ctd:D008999
Drug	Alitretinoin	RARA RARB	5.70e-05	6	45	2	DB00523
Drug	Adapalene	RARA RARB	5.70e-05	6	45	2	DB00210
Drug	Etretinate	RARA RARB	5.70e-05	6	45	2	DB00926
Drug	Acitretin	RARA RARB	7.97e-05	7	45	2	DB00459
Drug	HX 600	RARA RARB	1.06e-04	8	45	2	ctd:C104181
Drug	2-naphthoic acid	RARA RARB	1.06e-04	8	45	2	CID000007123
Drug	4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	RARA RARB	1.06e-04	8	45	2	ctd:C064545
Drug	Adapalene	RARA RARB	1.06e-04	8	45	2	ctd:D000068816
Drug	TTNN	RARA RARB	1.06e-04	8	45	2	CID000135754
Drug	4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid	RARA RARB	1.06e-04	8	45	2	ctd:C121616
Disease	airway responsiveness measurement	RARB SOBP BCAS3	4.94e-06	24	41	3	EFO_0006897
Disease	Neuralgia-Neuritis, Sciatic Nerve	RARA RARB	1.13e-05	4	41	2	C0751924
Disease	Sciatic Nerve Palsy	RARA RARB	1.13e-05	4	41	2	C0751925
Disease	Lesion of Sciatic Nerve	RARA RARB	1.13e-05	4	41	2	C0154748
Disease	Sciatic Neuritis	RARA RARB	1.13e-05	4	41	2	C0242013
Disease	Sciatic Neuropathy	RARA RARB	1.13e-05	4	41	2	C0149940
Disease	RS-warfarin measurement	NHSL1 NLGN1 RARB DNAH9	3.02e-05	128	41	4	EFO_0803325
Disease	wheezing	SPG11 NLGN1 RARB	1.02e-04	65	41	3	EFO_0009715
Disease	C-reactive protein measurement	NCOA6 SPG11 NLGN1 RARB PTPRF CEACAM20 PHF21A XPNPEP3	2.18e-04	1206	41	8	EFO_0004458
Disease	renal system measurement	SCAF8 BCAS3	3.52e-04	20	41	2	EFO_0004742
Disease	Autistic Disorder	NLGN1 NLGN4X MAOB NPAS2	4.68e-04	261	41	4	C0004352
Disease	Alcoholic Intoxication, Chronic	LHB NLGN4X GRM1 MAOB	5.17e-04	268	41	4	C0001973
Disease	Malignant neoplasm of breast	NCOA6 DDX59 ACVR1 RARA RARB DNAH9 TP53BP2	6.32e-04	1074	41	7	C0006142
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN1 NLGN4X MEF2A	1.24e-03	152	41	3	DOID:0060041 (implicated_via_orthology)
Disease	Schizophrenia	NLGN1 RARA GRM1 MAOB NUMBL NPAS2	1.30e-03	883	41	6	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDPKTLLPMPGVMVG	ACOX3	231	O15254
MPPLRLVSTVPKNME	CEACAM20	561	Q6UY09
TAVPGRLPVMTMIPD	GSR	311	P00390
MILPVLIMIALPSPS	ACVR1	6	Q04771
IPVLPQVMMILIPGQ	CRBN	81	Q96SW2
VQSTPIPMMPRHVPL	RAD54L2	1026	Q9Y4B4
RLSPLPSLMVVMPLA	BCAS3	516	Q9H6U6
MPRMPSRPELLVKPA	TP53BP2	356	Q13625
LVPMNTPGVKIIRPL	ACAD11	571	Q709F0
PMPRVPVVGITPSQM	NUMBL	501	Q9Y6R0
ITLKMEIPGSMPPLI	RARA	396	P10276
ITLKMEIPGSMPPLI	RARB	396	P10826
QLRLLLSQPIQPMMP	NPAS2	671	Q99743
SPVQPVLQGMVGMIP	NPAT	936	Q14207
PPLPMMRNQMITRVP	MAOB	276	P27338
TFRQVGQTMPMVPPL	MED14OS	111	P0DP75
MMRVLQAVLPPLPQV	LHB	61	P01229
PMTPLRTVMLIPGDK	BCCIP	286	Q9P287
PTPIQMQMIPVGLLG	DDX59	226	Q5T1V6
RPPMPLITTEALQMV	NHSL1	1066	Q5SYE7
PPMLAAPQLIQRPVM	PHF21A	251	Q96BD5
PDLRVVIPPSSKGMM	MEF2A	271	Q02078
MTPNTITMIPNTIPG	NLGN1	816	Q8N2Q7
RMGQPQITVRTMKPP	MYO15B	976	Q96JP2
PGIIRMNNPATVMIP	NCOA6	171	Q14686
IPEMVGPILEMTLIP	DOCK1	1081	Q14185
PSPKMMLGPVTLHLV	GLB1L	366	Q6UWU2
MHLIIVRGMNLPAPP	CC2D1B	701	Q5T0F9
PIPVTPALDPLRMLM	DNAH9	3416	Q9NYC9
VVTLIIMEPPMPILS	GRM1	721	Q13255
QRMPTMPMLDIRPGL	SCAF8	916	Q9UPN6
IPLMTPNTITMIPNT	NLGN4X	771	Q8N0W4
APGRTMVPLVPALVM	PTPRF	6	P10586
GQVMPALATTVMPVP	RTL4	41	Q6ZR62
VSRILMAAPGMAIPP	SFXN1	231	Q9H9B4
TLAMMIAGIPTVPVP	SPATA25	156	Q9BR10
MVPPVQVSPLIKLGR	ATP5ME	1	P56385
LPFQMPGMRLPETQV	AHNAK2	5306	Q8IVF2
AMGRVLPMLLVPVPA	SPG11	21	Q96JI7
LFPMNPMIPQTLIGL	ZFHX2	2381	Q9C0A1
VMTNRGPVPLPIFME	SOBP	386	A7XYQ1
VPRMIVTPQSNRPVM	POLR2A	521	P24928
MPRSLPLQPGMVITI	XPNPEP3	436	Q9NQH7
RLGTLPPSPMLLSMN	TINAG	191	Q9UJW2
PPTVTMPRIKALMTG	PIGG	111	Q5H8A4