Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphoglycerate kinase activity	PGK1 PGK2	5.90e-06	2	49	2	GO:0004618
GeneOntologyMolecularFunction	phosphotransferase activity, carboxyl group as acceptor	PGK1 PGK2	1.77e-05	3	49	2	GO:0016774
GeneOntologyMolecularFunction	estrogen response element binding	ESRRA ESRRB	3.20e-04	11	49	2	GO:0034056
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	BNC1 SOX21 SPI1 ESRRA ESRRB ETV1 ATF4	4.33e-04	566	49	7	GO:0001216
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1H	5.27e-04	14	49	2	GO:0008331
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	KMT2C SF3B1 SOX21 SPI1 ESRRA ESRRB MED12L ETV1 ATF4 NKX6-1 SERPINF2 MAP2K1	7.46e-05	1390	49	12	GO:0045944
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase I	BNC1 SF3B1 ATF4	9.25e-05	37	49	3	GO:0045943
GeneOntologyBiologicalProcess	purine nucleoside diphosphate catabolic process	ESRRB PGK1 ENTPD4 PGK2	1.71e-04	117	49	4	GO:0009137
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate catabolic process	ESRRB PGK1 ENTPD4 PGK2	1.71e-04	117	49	4	GO:0009181
GeneOntologyBiologicalProcess	ribonucleoside diphosphate catabolic process	ESRRB PGK1 ENTPD4 PGK2	1.95e-04	121	49	4	GO:0009191
GeneOntologyBiologicalProcess	nucleoside diphosphate catabolic process	ESRRB PGK1 ENTPD4 PGK2	2.14e-04	124	49	4	GO:0009134
GeneOntologyBiologicalProcess	regulation of transcription by RNA polymerase I	BNC1 SF3B1 ATF4	2.28e-04	50	49	3	GO:0006356
GeneOntologyBiologicalProcess	regulation of protein localization to chromatin	SPI1 VCPIP1	2.46e-04	10	49	2	GO:1905634
GeneOntologyBiologicalProcess	purine nucleoside diphosphate metabolic process	ESRRB PGK1 ENTPD4 PGK2	2.72e-04	132	49	4	GO:0009135
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate metabolic process	ESRRB PGK1 ENTPD4 PGK2	2.72e-04	132	49	4	GO:0009179
GeneOntologyCellularComponent	chromatin	BRPF3 SF3B1 SOX21 SPI1 ESRRA ESRRB SP6 ETV1 FAM47C ATF4 NKX6-1 FOXL1	1.20e-04	1480	49	12	GO:0000785
Domain	-	PGK1 PGK2	6.74e-06	2	49	2	3.40.50.1270
Domain	-	PGK1 PGK2	6.74e-06	2	49	2	3.40.50.1260
Domain	PGLYCERATE_KINASE	PGK1 PGK2	6.74e-06	2	49	2	PS00111
Domain	Phosphoglycerate_kinase_N	PGK1 PGK2	6.74e-06	2	49	2	IPR015824
Domain	PGK	PGK1 PGK2	6.74e-06	2	49	2	PF00162
Domain	Phosphoglycerate_kinase_CS	PGK1 PGK2	6.74e-06	2	49	2	IPR015911
Domain	Phosphoglycerate_kinase_C	PGK1 PGK2	6.74e-06	2	49	2	IPR015901
Domain	Oest-rel_rcp	ESRRA ESRRB	2.02e-05	3	49	2	IPR027289
Domain	Phosphoglycerate_kinase	PGK1 PGK2	2.02e-05	3	49	2	IPR001576
Domain	Oest_rcpt/oest-rel_rcp	ESRRA ESRRB	6.71e-05	5	49	2	IPR024178
Domain	Retinoid-X_rcpt/HNF4	ESRRA ESRRB	2.99e-04	10	49	2	IPR000003
Domain	VDCCAlpha1	CACNA1A CACNA1H	2.99e-04	10	49	2	IPR002077
Domain	Channel_four-helix_dom	CACNA1A SCN4A CACNA1H	4.49e-04	57	49	3	IPR027359
Domain	-	CACNA1A SCN4A CACNA1H	4.49e-04	57	49	3	1.20.120.350
Domain	Disintegrin_CS	ADAM12 ADAM22	7.90e-04	16	49	2	IPR018358
Domain	ADAM_CR	ADAM12 ADAM22	1.00e-03	18	49	2	PF08516
Domain	-	ADAM12 ADAM22	1.24e-03	20	49	2	4.10.70.10
Domain	DISIN	ADAM12 ADAM22	1.37e-03	21	49	2	SM00050
Domain	Disintegrin	ADAM12 ADAM22	1.37e-03	21	49	2	PF00200
Domain	EPHD	KMT2C BRPF3	1.51e-03	22	49	2	PS51805
Domain	ADAM_Cys-rich	ADAM12 ADAM22	2.27e-03	27	49	2	IPR006586
Domain	ACR	ADAM12 ADAM22	2.27e-03	27	49	2	SM00608
Domain	Ets	SPI1 ETV1	2.44e-03	28	49	2	PF00178
Domain	ETS_DOMAIN_1	SPI1 ETV1	2.44e-03	28	49	2	PS00345
Domain	ETS_DOMAIN_2	SPI1 ETV1	2.44e-03	28	49	2	PS00346
Domain	ETS	SPI1 ETV1	2.44e-03	28	49	2	SM00413
Domain	Ets_dom	SPI1 ETV1	2.44e-03	28	49	2	IPR000418
Domain	ETS_DOMAIN_3	SPI1 ETV1	2.44e-03	28	49	2	PS50061
Domain	Ion_trans_dom	CACNA1A SCN4A CACNA1H	3.33e-03	114	49	3	IPR005821
Domain	Ion_trans	CACNA1A SCN4A CACNA1H	3.33e-03	114	49	3	PF00520
Domain	Peptidase_M12B_N	ADAM12 ADAM22	4.70e-03	39	49	2	IPR002870
Domain	Pep_M12B_propep	ADAM12 ADAM22	4.70e-03	39	49	2	PF01562
Domain	DISINTEGRIN_1	ADAM12 ADAM22	4.94e-03	40	49	2	PS00427
Domain	ADAM_MEPRO	ADAM12 ADAM22	4.94e-03	40	49	2	PS50215
Domain	DISINTEGRIN_2	ADAM12 ADAM22	4.94e-03	40	49	2	PS50214
Domain	Reprolysin	ADAM12 ADAM22	4.94e-03	40	49	2	PF01421
Domain	Peptidase_M12B	ADAM12 ADAM22	4.94e-03	40	49	2	IPR001590
Domain	Disintegrin_dom	ADAM12 ADAM22	5.18e-03	41	49	2	IPR001762
Domain	zf-C4	ESRRA ESRRB	6.48e-03	46	49	2	PF00105
Domain	NUCLEAR_REC_DBD_1	ESRRA ESRRB	6.48e-03	46	49	2	PS00031
Domain	Znf_hrmn_rcpt	ESRRA ESRRB	6.48e-03	46	49	2	IPR001628
Domain	Nuclear_hrmn_rcpt	ESRRA ESRRB	6.48e-03	46	49	2	IPR001723
Domain	ZnF_C4	ESRRA ESRRB	6.48e-03	46	49	2	SM00399
Domain	NUCLEAR_REC_DBD_2	ESRRA ESRRB	6.48e-03	46	49	2	PS51030
Domain	-	ESRRA ESRRB	6.76e-03	47	49	2	1.10.565.10
Domain	HOLI	ESRRA ESRRB	7.04e-03	48	49	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	ESRRA ESRRB	7.04e-03	48	49	2	IPR000536
Domain	Hormone_recep	ESRRA ESRRB	7.04e-03	48	49	2	PF00104
Domain	HMG_box	KMT2C SOX21	8.53e-03	53	49	2	PF00505
Domain	HMG	KMT2C SOX21	8.85e-03	54	49	2	SM00398
Domain	-	ESRRA ESRRB	9.82e-03	57	49	2	3.30.50.10
Domain	Znf_NHR/GATA	ESRRA ESRRB	1.02e-02	58	49	2	IPR013088
Pathway	KEGG_LONG_TERM_DEPRESSION	CACNA1A PLA2G12B PRKG2 MAP2K1	5.41e-05	70	42	4	M8232
Pubmed	A census of human transcription factors: function, expression and evolution.	BNC1 SOX21 SPI1 ESRRA ESRRB SP6 ETV1 ATF4 NKX6-1 FOXL1	5.59e-07	908	50	10	19274049
Pubmed	Analysis of the cDNA and encoded protein of the human testis-specific PGK-2 gene.	PGK1 PGK2	2.03e-06	2	50	2	9023984
Pubmed	Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1.	PPP1R8 SF3B1	2.03e-06	2	50	2	12105215
Pubmed	Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.	PGK1 PGK2	2.03e-06	2	50	2	3453121
Pubmed	A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene.	PGK1 PGK2	2.03e-06	2	50	2	8441629
Pubmed	Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis.	ESRRA ESRRB	2.03e-06	2	50	2	8652414
Pubmed	Transcription switch of two phosphoglycerate kinase genes during spermatogenesis as determined with mouse testis sections in situ.	PGK1 PGK2	2.03e-06	2	50	2	2298243
Pubmed	Selective activation of testis-specific genes in cultured rat spermatogenic cells.	PGK1 PGK2	2.03e-06	2	50	2	2166582
Pubmed	Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme.	PGK1 PGK2	2.03e-06	2	50	2	5009693
Pubmed	The family of mouse phosphoglycerate kinase genes and pseudogenes.	PGK1 PGK2	2.03e-06	2	50	2	2829366
Pubmed	Characterization of phosphoglycerate kinase from human spermatozoa.	PGK1 PGK2	2.03e-06	2	50	2	1278465
Pubmed	Differential appearance of DNase I-hypersensitive sites correlates with differential transcription of Pgk genes during spermatogenesis in the mouse.	PGK1 PGK2	2.03e-06	2	50	2	8662942
Pubmed	Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis.	ESRRA ESRRB	2.03e-06	2	50	2	33446092
Pubmed	Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.	ESRRA ESRRB ATF4	4.85e-06	23	50	3	24349082
Pubmed	Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155).	PPP1R8 SF3B1	6.07e-06	3	50	2	18842582
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1A CACNA1H	6.07e-06	3	50	2	26216687
Pubmed	Uncommon somatic mutations in metastatic NUT midline carcinoma.	KMT2C SF3B1	6.07e-06	3	50	2	28967088
Pubmed	Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.	PGK1 PGK2	6.07e-06	3	50	2	1380672
Pubmed	Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.	ESRRA ESRRB	6.07e-06	3	50	2	29888756
Pubmed	Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.	ESRRA ESRRB	6.07e-06	3	50	2	15598686
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1A CACNA1H	6.07e-06	3	50	2	29581247
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KMT2C SOX21 ESRRA ESRRB SP6 ETV1 ATF4 FOXL1	7.23e-06	709	50	8	22988430
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1A CACNA1H	1.21e-05	4	50	2	31800012
Pubmed	Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2.	ESRRA ESRRB	1.21e-05	4	50	2	10598588
Pubmed	Identification of a new class of steroid hormone receptors.	ESRRA ESRRB	1.21e-05	4	50	2	3267207
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1A CACNA1H	1.21e-05	4	50	2	21788606
Pubmed	Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene.	ESRRA ESRRB	1.21e-05	4	50	2	18039682
Pubmed	Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma.	ESRRA ESRRB	1.21e-05	4	50	2	29940916
Pubmed	Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.	ESRRA ESRRB	2.02e-05	5	50	2	18509053
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	SPI1 ESRRA ATF4	2.10e-05	37	50	3	26147683
Pubmed	KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.	PGK1 PGK2	3.03e-05	6	50	2	22654668
Pubmed	Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.	ESRRA ESRRB	3.03e-05	6	50	2	21177257
Pubmed	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.	ESRRA ESRRB	3.03e-05	6	50	2	23836911
Pubmed	Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.	SOX21 ESRRB	3.03e-05	6	50	2	27015307
Pubmed	Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes.	ESRRA ESRRB	3.03e-05	6	50	2	16439465
Pubmed	Lsh, an epigenetic guardian of repetitive elements.	PGK1 PGK2	4.23e-05	7	50	2	15448183
Pubmed	Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene.	ESRRA ESRRB	4.23e-05	7	50	2	9344655
Pubmed	Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.	ATF4 MAP2K1	4.23e-05	7	50	2	23945236
Pubmed	Substrate specificity and activity regulation of protein kinase MELK.	PPP1R8 SF3B1	5.64e-05	8	50	2	16216881
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C CCNA2	5.64e-05	8	50	2	21447625
Pubmed	Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.	SPI1 ETV1	5.64e-05	8	50	2	9681824
Pubmed	Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.	ESRRA ESRRB	7.25e-05	9	50	2	34029594
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1H	7.25e-05	9	50	2	16382099
Pubmed	Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity.	ETV1 NKX6-1	7.25e-05	9	50	2	18215620
Pubmed	A systematic analysis of a deep mouse epididymal sperm proteome.	PGK1 PGK2	9.05e-05	10	50	2	23115268
Pubmed	A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.	BRPF3 ETV1 ATF4	9.49e-05	61	50	3	32911434
Pubmed	Shifted Transversal Design smart-pooling for high coverage interactome mapping.	RALYL CCDC120 ATF4	9.96e-05	62	50	3	19447967
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	PPP1R8 ESS2 CCDC120 ADAM22 CCNA2	1.13e-04	331	50	5	19490893
Pubmed	Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.	ETV1 NKX6-1	1.56e-04	13	50	2	25943695
Pubmed	Organization of motor pools depends on the combined function of N-cadherin and type II cadherins.	ETV1 NKX6-1	1.56e-04	13	50	2	31235635
Pubmed	Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.	SPI1 ETV1	1.82e-04	14	50	2	14635793
Pubmed	Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits.	ETV1 NKX6-1	2.10e-04	15	50	2	30593496
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	ETV1 NKX6-1	3.05e-04	18	50	2	31969659
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1A KMT2C SF3B1 NEURL4	3.55e-04	233	50	4	37704626
Pubmed	Nuclear Organization in the Spinal Cord Depends on Motor Neuron Lamination Orchestrated by Catenin and Afadin Function.	ETV1 NKX6-1	3.79e-04	20	50	2	29444423
Pubmed	The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.	SOX21 NKX6-1	4.18e-04	21	50	2	16306355
Pubmed	A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.	SOX21 ATF4 NKX6-1	4.34e-04	102	50	3	19741146
Pubmed	The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.	ETV1 CCNA2	4.59e-04	22	50	2	36877136
Pubmed	SEC23B is required for the maintenance of murine professional secretory tissues.	ATF4 NKX6-1	4.59e-04	22	50	2	22745161
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FRMPD3 NEURL4 VCPIP1	4.99e-04	107	50	3	11347906
Pubmed	POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia.	BNC1 ETV1	5.03e-04	23	50	2	17239249
Pubmed	Cerebellar cortical lamination and foliation require cyclin A2.	ESRRB CCNA2	5.03e-04	23	50	2	24184637
Pubmed	Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.	ETV1 MAP2K1	5.48e-04	24	50	2	32043969
Pubmed	FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination.	ETV1 MAP2K1	5.48e-04	24	50	2	30188892
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	SPI1 ETV1	5.48e-04	24	50	2	22056786
Pubmed	A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.	ETV1 ATF4	6.44e-04	26	50	2	26651292
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	ESRRA ESRRB NKX6-1	6.64e-04	118	50	3	16971476
Pubmed	Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.	NKX6-1 CCNA2	6.95e-04	27	50	2	31806625
Pubmed	RNA binding proteins co-localize with small tau inclusions in tauopathy.	SLC25A3 MAP2K1 PGK1 ADAM22	7.36e-04	283	50	4	30068389
Pubmed	The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.	ESS2 ESRRA	7.48e-04	28	50	2	11984006
Pubmed	Motor neuron position and topographic order imposed by β- and γ-catenin activities.	ETV1 NKX6-1	8.02e-04	29	50	2	22036570
Pubmed	Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation.	ETV1 NKX6-1	8.02e-04	29	50	2	37610090
Pubmed	ETS-family genes in pancreatic development.	SPI1 ETV1	8.02e-04	29	50	2	17907201
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	SPI1 ETV1	8.02e-04	29	50	2	26097038
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	KMT2C SF3B1	8.59e-04	30	50	2	17403666
Pubmed	Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.	SPI1 ETV1	8.59e-04	30	50	2	21575865
Pubmed	GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.	ETV1 NKX6-1	8.59e-04	30	50	2	21943603
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PPP1R8 KMT2C	9.17e-04	31	50	2	20516061
Pubmed	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.	ATF4 PGK1	9.17e-04	31	50	2	22925884
Pubmed	Specific functions for ERK/MAPK signaling during PNS development.	ETV1 MAP2K1	9.17e-04	31	50	2	21220101
Pubmed	Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.	ETV1 MAP2K1	9.77e-04	32	50	2	29028795
Pubmed	Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.	ETV1 NKX6-1	1.04e-03	33	50	2	18662545
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	CACNA1A CACNA1H	1.04e-03	33	50	2	19336002
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1A SCN4A CACNA1H	1.07e-03	139	50	3	16985003
Pubmed	Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.	ESRRA CCNA2	1.10e-03	34	50	2	23342106
Pubmed	Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.	SOX21 SFTPB	1.17e-03	35	50	2	18374910
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	NKX6-1 FOXL1	1.24e-03	36	50	2	27736991
Pubmed	Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.	SFTPB CCNA2	1.31e-03	37	50	2	30389914
Pubmed	Ion channel expression in the developing enteric nervous system.	CACNA1A CACNA1H	1.31e-03	37	50	2	25798587
Pubmed	Large-scale concatenation cDNA sequencing.	SF3B1 SLC16A2 RALYL ETV1 CACNA1H	1.32e-03	568	50	5	9110174
Pubmed	Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung.	SFTPB CCNA2	1.38e-03	38	50	2	27141870
Pubmed	A "double adaptor" method for improved shotgun library construction.	SF3B1 SLC16A2 RALYL ETV1 CACNA1H	1.38e-03	574	50	5	8619474
Cytoband	17p13	SERPINF2 NEURL4	6.38e-04	34	50	2	17p13
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1H	1.02e-03	26	33	2	253
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM12 ADAM22	1.10e-03	27	33	2	47
GeneFamily	ETS transcription factor family	SPI1 ETV1	1.19e-03	28	33	2	534
GeneFamily	Nuclear hormone receptors	ESRRA ESRRB	3.60e-03	49	33	2	71
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-D_(AT2)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	SLC25A3 SPI1 SFTPB ATF4 SERPINF2	2.83e-06	198	50	5	963b7ff8c5322d9290bbaf42137bb8fdd0672db9
Drug	S-(+)-ibuprofen [51146-56-6]; Up 200; 19.4uM; PC3; HT_HG-U133A	CACNA1A SOX21 SPI1 SFTPB PGK2 ADAM22	3.65e-06	194	49	6	6712_UP
Drug	Trapidil [15421-84-8]; Up 200; 19.4uM; MCF7; HT_HG-U133A	CACNA1A SFTPB CACNA1H PRKG2 ADAM22 VCPIP1	4.11e-06	198	49	6	7475_UP
Drug	4-Arsono-2-hydroxybutanoic acid	PGK1 PGK2	4.54e-06	2	49	2	CID000135804
Drug	equol	ESRRA ESRRB MAP2K1 CCNA2	9.03e-06	61	49	4	CID000091469
Drug	Dirian	PGK1 PGK2	1.36e-05	3	49	2	CID003034337
Drug	AC1NDNJY	PGK1 PGK2	1.36e-05	3	49	2	CID004578722
Drug	AC1O5U9L	PGK1 PGK2	1.36e-05	3	49	2	CID006440811
Drug	repin	PGK1 PGK2	2.71e-05	4	49	2	CID000091567
Drug	gluconate	SLC25A3 ESRRA ESRRB PGK1 PGK2 CCNA2	3.38e-05	287	49	6	CID000000604
Drug	clorsulon	PGK1 PGK2	4.52e-05	5	49	2	CID000043231
Drug	XCT790	ESRRA ESRRB	4.52e-05	5	49	2	CID006918788
Drug	Boldine [476-70-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	SOX21 SFTPB PRKG2 ADAM12 ADAM22	5.85e-05	193	49	5	4122_UP
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; PC3; HT_HG-U133A	SFTPB ETV1 SERPINF2 ADAM12 ADAM22	5.85e-05	193	49	5	4477_UP
Drug	Azathioprine [446-86-6]; Up 200; 14.4uM; MCF7; HT_HG-U133A	SFTPB ESRRA ENTPD4 ADAM22 VCPIP1	6.45e-05	197	49	5	1528_UP
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A	LMF2 SCN4A CACNA1H PRKG2 ADAM22	6.45e-05	197	49	5	4131_UP
Drug	sulindac; Up 200; 100uM; MCF7; HG-U133A	LMF2 SFTPB SLC16A2 ESRRA CACNA1H	6.61e-05	198	49	5	168_UP
Drug	Panthenol (D) [81-13-0]; Down 200; 19.4uM; PC3; HT_HG-U133A	LMF2 ESS2 NOL6 ADAM12 VCPIP1	6.61e-05	198	49	5	1802_DN
Drug	CDVpp	PGK1 PGK2	6.77e-05	6	49	2	CID000501655
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1H	6.77e-05	6	49	2	CID000583065
Drug	esperamicin A1	PGK1 PGK2	6.77e-05	6	49	2	CID006435576
Drug	Benzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CACNA1A ESRRA ADAM12 ADAM22 FOXL1	6.93e-05	200	49	5	6839_UP
Drug	4-HT	ESRRA ESRRB MAP2K1 CCNA2	7.71e-05	105	49	4	CID005284643
Drug	HFIP	SFTPB PGK1 PGK2	8.75e-05	40	49	3	CID000013529
Drug	SC-11927	PGK1 PGK2	9.46e-05	7	49	2	CID003034422
Drug	ethyl octanoate	PGK1 PGK2	9.46e-05	7	49	2	CID000007799
Drug	zirconium	SLC25A3 ESRRA ESRRB CCNA2	9.57e-05	111	49	4	CID000023995
Drug	Bepridil	CACNA1A CACNA1H	1.26e-04	8	49	2	DB01244
Drug	ethyl decanoate	PGK1 PGK2	1.26e-04	8	49	2	CID000008048
Drug	trifluoroethanol	SFTPB ETV1 PGK1 PGK2	1.42e-04	123	49	4	CID000006409
Drug	amlodipine	CACNA1A SLC16A2 CACNA1H ATF4	1.56e-04	126	49	4	CID000002162
Drug	2C5P	SFTPB ESRRA ESRRB CCNA2	1.61e-04	127	49	4	CID000447961
Drug	phenethyl acetate	PGK1 PGK2	1.62e-04	9	49	2	CID000007654
Drug	AC1MI08J	PGK1 PGK2	1.62e-04	9	49	2	CID003035924
Drug	U23,469	ESRRA ESRRB	1.62e-04	9	49	2	CID000161922
Drug	Rh(H2O)4ATP	PGK1 PGK2	1.62e-04	9	49	2	CID003082848
Drug	chloroethylguanine	PGK1 PGK2	1.62e-04	9	49	2	CID000161383
Drug	2-methoxy-5-nitrotropone	PGK1 PGK2	1.62e-04	9	49	2	CID000084563
Drug	1 mN-9	PGK1 PGK2	2.02e-04	10	49	2	CID000122108
Drug	ACVDP	PGK1 PGK2	2.02e-04	10	49	2	CID000501523
Drug	25-azacoprostane	PGK1 PGK2	2.02e-04	10	49	2	CID000162243
Disease	Childhood Absence Epilepsy	CACNA1A CACNA1H	5.19e-05	7	47	2	C4281785
Disease	Epilepsy, Minor	CACNA1A CACNA1H	5.19e-05	7	47	2	C4552765
Disease	Absence Epilepsy	CACNA1A CACNA1H	5.19e-05	7	47	2	C0014553
Disease	Akinetic Petit Mal	CACNA1A CACNA1H	5.19e-05	7	47	2	C0001890
Disease	Epilepsy, Absence, Atypical	CACNA1A CACNA1H	5.19e-05	7	47	2	C0751124
Disease	Absence Seizure Disorder	CACNA1A CACNA1H	5.19e-05	7	47	2	C4553705
Disease	Juvenile Absence Epilepsy	CACNA1A CACNA1H	5.19e-05	7	47	2	C4317339
Disease	cancer (implicated_via_orthology)	ESRRA ESRRB MAP2K1 PGK1 PGK2	6.69e-05	268	47	5	DOID:162 (implicated_via_orthology)
Disease	acute myeloid leukemia (implicated_via_orthology)	SF3B1 SPI1	1.62e-04	12	47	2	DOID:9119 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	NEK4 PRKG2 MAP2K1	4.88e-04	96	47	3	C1319315
Disease	azoospermia (implicated_via_orthology)	ESRRA ESRRB	8.50e-04	27	47	2	DOID:14227 (implicated_via_orthology)
Disease	glycocholate measurement	NOL6 ADAM12	1.05e-03	30	47	2	EFO_0010491
Disease	uridine measurement	ESRRB ETV1	1.19e-03	32	47	2	EFO_0010546

Protein segments in the cluster

Peptide	Gene	Start	Entry
EPAPALGDPDMYVPL	BEST4	276	Q8NFU0
EDDRGEDGPKPMPPY	CACNA1A	1206	O00555
YIPPLDRPPKETEPM	CFAP54	2936	Q96N23
GPDLKLVPPMEEDYP	SERPINF2	471	P08697
ARPKPYDPPGEKMVA	ATF4	256	P18848
PLPPALIGSLPEQYM	BNC1	251	Q01954
SSRKYPYPMPPLPDE	ADAM22	876	Q9P0K1
GYPSYPALIIDPKMP	BRPF3	1086	Q9ULD4
LGKGLMRKPPDSYPP	ADAM12	771	O43184
MRKPPDSYPPKDNPR	ADAM12	776	O43184
KMLAPDPDPNGELLP	SLC16A2	516	P36021
MAVGRYPIPPPDAKE	MAP2K1	256	Q02750
YPIPPPDAKELELMF	MAP2K1	261	Q02750
RPDGVPMPDKYSLAP	PGK2	66	P07205
DINMAGEPKPYRPKP	RALYL	86	Q86SE5
EPPKTRMYSLRPEPP	FAM47C	561	Q5HY64
VKVYFRLPRPPPPEM	SLC25A3	336	Q00325
DPYAKMVGTPRPPPV	KMT2C	1896	Q8NEZ4
DPYAKPPDTPRPVMT	KMT2C	1961	Q8NEZ4
PMPKPRSYYLQPLPL	MED12L	1716	Q86YW9
LLTMLPGPPPVYAAD	CCDC120	481	Q96HB5
GKLPPMPRDYSPELA	NEK4	221	P51957
PPPLMIKQEPRDFAY	ETV1	251	P50549
LPRLDKPCPAYVEPM	NOL6	721	Q9H6R4
KRTPLLPPPDYPQTM	DNAH12	71	Q6ZR08
GKAPMPRPGYKPQEP	PLA2G12B	71	Q9BX93
RPDGVPMPDKYSLEP	PGK1	66	P00558
FDKYPPEKGMPPDEL	PRKG2	741	Q13237
LGKMSREPPPPYVTP	ESS2	91	Q96DF8
PASQPLPPPMIKADY	FRMPD3	501	Q5JV73
YPHPPLGMLPREAKE	FRMPD3	1446	Q5JV73
PAMPYAPEKLPSPAL	MAMLD1	401	Q13495
PMLYLYGPERPGLPL	FOXL1	16	Q12952
LLVAEPDKLYAMPPP	ESRRB	216	O95718
GPRKPLVPLDYPMDG	CCNA2	136	P20248
MPLRKPGGPFYVPES	B3GNT8	281	Q7Z7M8
PMPVGDPPEKRRGLY	CACNA1H	2311	O95180
PEKLYAMPDPAGPDG	ESRRA	206	P11474
LLPEDYFMPPPKRSL	NEURL4	1351	Q96JN8
EPLMLPPPVELGYRV	POM121L1P	211	Q3SYA9
PLMLPPPLELGYRVT	nan	171	A6NNC1
PEDLMPRPLPYHLPS	ARHGAP30	241	Q7Z6I6
LLPGMGKPQLDPYPA	SOX21	256	Q9Y651
LIGGLPMPYPNLAPD	PPP1R8	286	Q12972
GKNLPMIYGDPPPEV	SCN4A	61	P35499
MSDPLPKPLRDPLPD	SFTPB	156	P07988
IEFMYKPGNLSRPPP	LMF2	481	Q9BU23
MKTPLYPAAYPPLPA	NKX6-1	31	P78426
TGLTPDMPYLDPCLP	ENTPD4	356	Q9Y227
KMEGFPLVPPPSEDL	SPI1	6	P17947
PLAPGPFSKLLQPDM	SP6	86	Q3SY56
RPYLPEGPLIKIDMP	XKR6	576	Q5GH73
GVELPSYLPLYPPAM	VPS35L	381	Q7Z3J2
AMFPEGYKVLPPPAG	SF3B1	406	O75533
CIRYGFPPKELMPPQ	VCPIP1	816	Q96JH7