Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentnuclear speck

SF3A3 CACNB4 SRSF10 PRPF8 CWC22 CLK2

7.25e-05431356GO:0016607
GeneOntologyCellularComponentU2-type precatalytic spliceosome

SF3A3 PRPF8 CWC22

8.47e-0551353GO:0071005
GeneOntologyCellularComponentprecatalytic spliceosome

SF3A3 PRPF8 CWC22

1.01e-0454353GO:0071011
GeneOntologyCellularComponentU2-type catalytic step 1 spliceosome

PRPF8 CWC22

2.45e-0414352GO:0071006
GeneOntologyCellularComponentcatalytic step 1 spliceosome

PRPF8 CWC22

2.45e-0414352GO:0071012
GeneOntologyCellularComponentcatalytic step 2 spliceosome

SF3A3 PRPF8 CWC22

5.69e-0497353GO:0071013
GeneOntologyCellularComponentU2-type spliceosomal complex

SF3A3 PRPF8 CWC22

5.69e-0497353GO:0005684
GeneOntologyCellularComponentnuclear body

SF3A3 CACNB4 SRSF10 SETX PRPF8 CWC22 CLK2

6.38e-04903357GO:0016604
GeneOntologyCellularComponentU2-type catalytic step 2 spliceosome

PRPF8 CWC22

1.23e-0331352GO:0071007
PathwayWP_MRNA_PROCESSING

SF3A3 SRSF10 PRPF8 CLK2

9.11e-05126274M39406
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

NUP133 SF3A3 SRSF10 PRPF8 CWC22

1.60e-04277275MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

NUP133 SF3A3 SRSF10 PRPF8 CWC22

1.77e-04283275M13087
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

NUP133 SF3A3 LAMC2 SRSF10 CKAP4 ZFC3H1 PRPF8 SND1 SPEN CWC22

3.96e-071257361036526897
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

SF3A3 SRSF10 CKAP4 ZFC3H1 PRPF8 SND1 SPEN CWC22

6.59e-0773136829298432
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

KMT2A TAOK3 KCNQ4

3.28e-062836327256596
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

NUP133 SF3A3 SRSF10 HERC1 PRPF8 SND1 HNF4A CLK2 PSMA6

4.74e-06128436917353931
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SF3A3 KMT2A SRSF10 SETX CKAP4 PRPF8 SPEN CWC22

4.76e-0695436836373674
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NUP133 SF3A3 KMT2A SRSF10 SETX CKAP4 ZFC3H1 PRPF8 SPEN

5.04e-06129436930804502
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SF3A3 KMT2A TAOK3 SRSF10 PRPF8 SND1 CWC22 CLK2 PSMA6

5.85e-06131836930463901
Pubmed

Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways.

KLF10 HNF4A

6.24e-06436238582490
Pubmed

RNA-binding protein SPEN controls hepatocyte maturation via regulating Hnf4α expression during liver development.

HNF4A SPEN

1.04e-05536236577249
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

NUP133 SF3A3 SRSF10 CKAP4 PRPF8 SND1 SPEN CWC22 PSMA6

1.10e-05142536930948266
Pubmed

The multifunctional human p100 protein 'hooks' methylated ligands.

PRPF8 SND1

2.18e-05736217632523
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NUP133 SF3A3 KMT2A SRSF10 CKAP4 ZFC3H1 PRPF8

2.23e-0584736735850772
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

SF3A3 SRSF10 PRPF8 SND1 SPEN

2.81e-0534736516033648
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

PRPF8 RIMS2 CLK2 DSCAML1 PSMA6

3.26e-0535836532460013
Pubmed

Structure of a human catalytic step I spliceosome.

PRPF8 CWC22

4.66e-051036229301961
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

KMT2A LAMC2 TAOK3 SETX LMBRD2 CWC22

5.03e-0565036638777146
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

SF3A3 SRSF10 PRPF8 CWC22

5.10e-0519736422365833
Pubmed

Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.

SF3A3 PRPF8

5.70e-051136221283520
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NUP133 SF3A3 SRSF10 SETX CKAP4 PRPF8 SND1 PSMA6

5.88e-05135336829467282
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NUP133 SF3A3 SRSF10 CKAP4 PRPF8 SND1 SPEN

7.43e-05102436724711643
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

TAOK3 CKAP4 SND1 CWC22 CLK2 PSMA6

7.64e-0570136630196744
Pubmed

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.

NUP133 SF3A3 PRPF8 SND1

7.83e-0522036434091597
Pubmed

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

SF3A3 PRPF8 CWC22

7.92e-058036311991638
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

NUP133 SF3A3 KMT2A CKAP4 LMBRD2 PRPF8 SND1 PSMA6

9.09e-05144036830833792
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KMT2A SRSF10 ZFC3H1 PRPF8 RIMS2 SND1 SPEN PSMA6

9.18e-05144236835575683
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

HERC1 PRPF8 SND1 PSMA6

9.45e-0523136436597993
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SF3A3 SRSF10 SETX CKAP4 PRPF8 SPEN CWC22

1.05e-04108236738697112
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

NUP133 KMT2A SETX SPEN CLK2

1.17e-0446936527634302
Pubmed

Structure of the human activated spliceosome in three conformational states.

SF3A3 CWC22

1.24e-041636229360106
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

KMT2A SPEN CWC22 CLK2

1.30e-0425136431076518
Pubmed

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.

SF3A3 CKAP4 SND1

1.32e-049536333863777
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

SRSF10 CKAP4 SND1 SPEN

1.45e-0425836437794589
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

SF3A3 SRSF10 CKAP4 PRPF8 SND1 SPEN

1.65e-0480736622681889
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

KMT2A SPEN CWC22

1.68e-0410336332744500
Pubmed

BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.

SRSF10 PRPF8

1.76e-041936225263594
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

SF3A3 PRPF8 SND1

2.09e-0411136332683582
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KMT2A STOX2 SRSF10 SETX GPBP1 ARHGEF17

2.34e-0486136636931259
Pubmed

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.

CKAP4 PRPF8 PSMA6

2.90e-0412436335516420
Pubmed

FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

SF3A3 HERC1 PSMA6

3.18e-0412836328027390
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SF3A3 KMT2A PRPF8 SND1 SPEN

3.78e-0460536528977666
Pubmed

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

CKAP4 ZFC3H1 PRPF8 PSMA6

3.82e-0433336436779763
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

NUP133 SF3A3 CKAP4 PRPF8 SND1

3.84e-0460736539147351
Pubmed

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

PRPF8 SND1

3.87e-042836219596686
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

SRSF10 SETX CKAP4 PRPF8 SND1

4.08e-0461536531048545
Pubmed

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PRPF8 CWC22

4.45e-043036228076346
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

PRPF8 SND1 PSMA6

4.49e-0414436335681168
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

NUP133 SRSF10 CKAP4 PRPF8 SND1

4.82e-0463836533239621
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

SF3A3 SRSF10 KLF10 PRPF8 SND1 CWC22

4.89e-0498936636424410
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

SETX HERC1 CLK2

4.96e-0414936325184681
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NUP133 KMT2A PRPF8 SND1 SPEN

5.35e-0465336522586326
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

NUP133 SRSF10 PRPF8 SND1 CWC22

5.62e-0466036532780723
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

KMT2A HERC1 CLK2

5.78e-0415736330686591
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

NUP133 CKAP4 PRPF8 SND1

5.97e-0437536432788342
Pubmed

Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

NUP133 SF3A3 SND1 PSMA6

6.09e-0437736425147182
Pubmed

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

ZFC3H1 PRPF8 SND1

6.21e-0416136332572027
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SRSF10 ZFC3H1 SND1

6.44e-0416336322113938
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNB4 KCNQ4

6.78e-043736225798587
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

SRSF10 PRPF8 CWC22

7.15e-0416936323084401
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

NUP133 KMT2A

7.93e-044036237516964
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

SF3A3 SRSF10 PRPF8 CWC22 PSMA6

8.00e-0471436528302793
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

SF3A3 PRPF8 SPEN CWC22

8.32e-0441036426949251
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

CKAP4 ZFC3H1 PRPF8 SND1 SPEN

8.52e-0472436536232890
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

KMT2A TAOK3 SETX SND1 SPEN PSMA6

8.65e-04110336634189442
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

SF3A3 CKAP4 PRPF8 SND1

9.26e-0442236427342126
Pubmed

Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.

CACNB4 KCNQ4

9.59e-044436220200978
InteractionEED interactions

NUP133 SF3A3 CACNB4 SRSF10 SETX CKAP4 PRPF8 SND1 HNF4A SPEN CWC22 CLK2

4.37e-0614453612int:EED
InteractionNUP43 interactions

NUP133 KMT2A SRSF10 SETX ZFC3H1 SND1 SPEN CWC22

1.15e-05625368int:NUP43
InteractionSNRNP40 interactions

SF3A3 KMT2A SRSF10 SETX ZFC3H1 PRPF8 SPEN CWC22

1.32e-05637368int:SNRNP40
InteractionSPEN interactions

SF3A3 PRPF8 HNF4A SPEN CWC22

1.53e-05178365int:SPEN
InteractionYWHAH interactions

KMT2A STOX2 SRSF10 SETX HERC1 GPBP1 RIMS2 ARHGEF17 CWC22 CLK2

1.58e-0511023610int:YWHAH
InteractionZC3H18 interactions

SF3A3 SRSF10 CKAP4 ZFC3H1 PRPF8 SND1 SPEN CWC22 CLK2

1.75e-05877369int:ZC3H18
InteractionNFKBIL1 interactions

SRSF10 SPEN CWC22 CLK2

2.24e-0593364int:NFKBIL1
InteractionPRC1 interactions

NUP133 SF3A3 LAMC2 SRSF10 HERC1 PRPF8 ARHGEF17 SPEN CWC22

3.97e-05973369int:PRC1
InteractionISY1-RAB43 interactions

SF3A3 PRPF8 PSMA6

4.58e-0539363int:ISY1-RAB43
InteractionPPWD1 interactions

SF3A3 PRPF8 SPEN CWC22

4.81e-05113364int:PPWD1
InteractionPRPF18 interactions

GPBP1 PRPF8 SPEN CWC22

6.08e-05120364int:PRPF18
InteractionMEN1 interactions

NUP133 SF3A3 KMT2A SRSF10 CKAP4 ZFC3H1 PRPF8 ARHGEF17 SPEN

6.14e-051029369int:MEN1
InteractionPAXBP1 interactions

SF3A3 PRPF8 SPEN CWC22

6.28e-05121364int:PAXBP1
InteractionABCA1 interactions

LIN7B PRPF8 RIMS2

1.22e-0454363int:ABCA1
InteractionSUZ12 interactions

NUP133 SF3A3 SRSF10 SETX PRPF8 HNF4A CLK2

1.23e-04644367int:SUZ12
InteractionCACTIN interactions

PRPF8 SPEN CWC22 CLK2

1.23e-04144364int:CACTIN
InteractionNR2C2 interactions

SF3A3 KMT2A TAOK3 SRSF10 PRPF8 SND1 HNF4A CWC22 CLK2 PSMA6

1.23e-0414033610int:NR2C2
InteractionPRPF40A interactions

SF3A3 SRSF10 PRPF8 SND1 SPEN CWC22

1.26e-04446366int:PRPF40A
InteractionOBSL1 interactions

NUP133 SF3A3 SRSF10 CKAP4 PRPF8 SND1 SPEN ZNF764

1.54e-04902368int:OBSL1
InteractionNKAPD1 interactions

SF3A3 SRSF10 CWC22 CLK2

1.89e-04161364int:NKAPD1
InteractionSNRPA interactions

SF3A3 SRSF10 ZFC3H1 PRPF8 CWC22 CLK2

1.92e-04482366int:SNRPA
InteractionSRSF6 interactions

KMT2A SRSF10 ZFC3H1 SND1 SPEN CLK2

2.42e-04503366int:SRSF6
InteractionCRNKL1 interactions

SF3A3 PRPF8 SPEN CWC22

2.72e-04177364int:CRNKL1
InteractionPRP4K interactions

SF3A3 PRPF8 SPEN CWC22 CLK2

2.80e-04329365int:PRP4K
InteractionSRSF3 interactions

SF3A3 SRSF10 PRPF8 SND1 SPEN CLK2

2.95e-04522366int:SRSF3
InteractionCPSF6 interactions

SRSF10 ZFC3H1 PRPF8 SND1 CWC22 CLK2

3.07e-04526366int:CPSF6
InteractionTRIR interactions

SF3A3 PRPF8 CWC22

3.11e-0474363int:TRIR
InteractionSMC5 interactions

SF3A3 KMT2A SRSF10 SETX CKAP4 PRPF8 SPEN CWC22

3.12e-041000368int:SMC5
InteractionSNRNP27 interactions

SF3A3 SPEN CWC22 CLK2

3.15e-04184364int:SNRNP27
InteractionZNF830 interactions

SF3A3 CKAP4 PRPF8

3.36e-0476363int:ZNF830
InteractionPAXIP1 interactions

KMT2A SRSF10 PRPF8 HNF4A PSMA6

4.18e-04359365int:PAXIP1
InteractionMETTL14 interactions

SF3A3 SRSF10 HERC1 PRPF8 SND1 PSMA6

4.21e-04558366int:METTL14
InteractionBIRC3 interactions

NUP133 SF3A3 SRSF10 CKAP4 PRPF8 SND1 SPEN CWC22 PSMA6

4.37e-041334369int:BIRC3
InteractionFRG1 interactions

SF3A3 PRPF8 CWC22

4.68e-0485363int:FRG1
InteractionDOT1L interactions

NUP133 SF3A3 KMT2A SRSF10 CKAP4 ZFC3H1 PRPF8

4.86e-04807367int:DOT1L
InteractionSLFN11 interactions

NUP133 SF3A3 SETX CKAP4 SND1

5.16e-04376365int:SLFN11
InteractionTHOC1 interactions

SF3A3 ZFC3H1 SPEN CWC22

5.20e-04210364int:THOC1
InteractionPIP4K2A interactions

CKAP4 PRPF8 SPEN CWC22

5.78e-04216364int:PIP4K2A
InteractionZMYND11 interactions

KMT2A SRSF10 PRPF8

6.28e-0494363int:ZMYND11
InteractionCUL7 interactions

SF3A3 SRSF10 CKAP4 ZFC3H1 PRPF8 SND1 SPEN

6.39e-04845367int:CUL7
Cytoband11q23

KMT2A DSCAML1

3.70e-043636211q23
Cytoband19q13.43

ZNF584 ZNF549

2.14e-038736219q13.43
ToppCellCiliated_cells-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

TEKT1 HNF4A DSCAML1 CCDC78

8.10e-061593640c65ae6140abd48c79b04758a6217709ddd15385
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

KMT2A HERC1 NALCN DSCAML1

1.24e-05177364e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

STOX2 RIMS2 HNF4A DSCAML1

1.41e-051833646878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIN7B CACNB4 RIMS2 ARHGEF17

1.44e-05184364f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2A HERC1 GPBP1 SPEN

1.57e-05188364ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell(07)_Brush|World / shred by cell type and Timepoint

STOX2 CACNB4 KCNQ4 DSCAML1

1.74e-051933649af9d22a130ff97a9c37142a65e841b056d08640
ToppCellwk_20-22-Epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TEKT1 LAMC2 TMC4 CCDC78

1.88e-05197364468071c1911cdf8e8806a78dbceb95379e28ae91
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2A SRSF10 ZFC3H1 HERC1

1.88e-0519736457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCelldistal-2-Epithelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 TMC4 CCDC78

2.00e-052003642fc1e95706f212bf18ecdf6eb5b3182ac98c9b52
ToppCellmedial-2-Epithelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 TMC4 CCDC78

2.00e-052003640079041c3e654c1ef77c492bdb2f31ce8f4b507b
ToppCellmedial-Epithelial|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 TMC4 CCDC78

2.00e-0520036417bb9a9016058cbb70c7bd894c12f6208ff07895
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2A SRSF10 SETX ZFC3H1

2.00e-0520036412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

TEKT1 LAMC2 CCDC78

2.68e-0415636310d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

TAOK3 NALCN ARHGEF17

2.94e-04161363347edb0de10850b7d16c40945751033289289c9b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 RIMS2 DSCAML1

3.11e-041643631cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 KCNQ4 CCDC78

3.63e-04173363d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 KCNQ4 CCDC78

3.63e-041733633c852ffe22f4a5b632463086b08c669310684e80
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMC2 TMC4 DSCAML1

3.88e-041773639af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIN7B LAMC2 ARHGEF17

4.08e-041803635b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LIN7B LAMC2 ARHGEF17

4.08e-04180363d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

STOX2 HNF4A DSCAML1

4.08e-04180363358923e4228035a3e90e2957392089219e90dcd7
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIN7B CACNB4 ARHGEF17

4.08e-0418036378fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.15e-041813638dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMC2 TMC4 DSCAML1

4.15e-04181363b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.21e-041823632075efeae633550fb2eb026d0dfd741c8252482e
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

RIMS2 NALCN DSCAML1

4.21e-0418236357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RIMS2 HNF4A DSCAML1

4.28e-041833638820cfed27b292bc0bc9cde4005219ed41900552
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TEKT1 HNF4A CCDC78

4.28e-0418336358847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCellLV-07._Pericyte|World / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.28e-04183363273db6a3b00a93ca852498471187b642b5368185
ToppCellLA-07._Pericyte|World / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.28e-04183363e3835db4795362b0442d5893baf2a78efcc20428
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB4 ARHGEF17 KCNQ4

4.28e-041833630e8fb371d8eac777451c76f41d53577f5dfb740d
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB4 ARHGEF17 KCNQ4

4.28e-04183363cbc3b00faa7e4e0dbbbc8ee105467c65241c7470
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

STOX2 HNF4A DSCAML1

4.42e-041853631bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TAOK3 HNF4A DSCAML1

4.42e-041853631d874608aa2062024323512f68889219471b2f00
ToppCellLV-07._Pericyte|LV / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.42e-04185363acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 RIMS2 DSCAML1

4.49e-04186363f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.49e-04186363c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 RIMS2 DSCAML1

4.56e-04187363c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

TMC4 ARHGEF17 DSCAML1

4.56e-04187363dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

STOX2 HNF4A DSCAML1

4.56e-04187363738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 RIMS2 DSCAML1

4.63e-04188363af740fa78542438fdff627ea1f74f4eee43316be
ToppCellfacs-Lung-EPCAM-24m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT1 TMC4 CCDC78

4.63e-04188363c2ef270f691d367b1621d48f0771267cefe1630d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC2 RIMS2 DSCAML1

4.70e-041893638c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC2 RIMS2 DSCAML1

4.70e-041893635d902a4660a27548764bf04c6de152b565da835c
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

STOX2 NALCN DSCAML1

4.78e-041903636e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TEKT1 LAMC2 CCDC78

4.85e-041913632a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEKT1 LAMC2 CCDC78

4.85e-041913632d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEKT1 LAMC2 CCDC78

4.85e-0419136346c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

TEKT1 LAMC2 CCDC78

4.85e-04191363ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

TEKT1 LAMC2 CCDC78

4.85e-04191363995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEKT1 LAMC2 CCDC78

4.85e-04191363a37f20172b85566b9039254a89680e37fd503fd5
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

TEKT1 LAMC2 CCDC78

4.85e-041913636228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TEKT1 TMC4 CCDC78

4.92e-0419236303acd4a26b986e34eee608747347791122f1aa52
ToppCellfacs-Lung-24m-Epithelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT1 TMC4 CCDC78

4.92e-04192363ebfd8209a7353fbccb8ca7ade14b4f25822cebd2
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TAOK3 ZFC3H1 KLF10

4.92e-041923636bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TEKT1 TMC4 CCDC78

4.92e-0419236331c6046589e2fbb0486fd044c5b128099d37872f
ToppCellcontrol-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KMT2A SETX AOAH

5.00e-0419336389d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC2 STOX2 DSCAML1

5.08e-04194363e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellMild-CD8+_T|World / Disease group and Cell class

KMT2A HERC1 AOAH

5.08e-04194363d64c2efb482bcdef9240977eae1023c4191286e7
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT1 TMC4 CCDC78

5.15e-04195363ed052c6d3dc104b02e34b645abfdee477af050c6
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CKAP4 KLF10 GPBP1

5.31e-04197363e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

TEKT1 LAMC2 CCDC78

5.31e-0419736318fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCelldistal-Hematologic-Platelet/Megakaryocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 CCDC78

5.31e-04197363751ffb8792058384079ebfe94872b3525f1aea84
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TEKT1 LAMC2 CCDC78

5.31e-04197363d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCelldistal-Hematologic-Platelet/Megakaryocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 CCDC78

5.31e-04197363e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKAP4 KLF10 GPBP1

5.31e-041973630353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TAOK3 SETX GPBP1

5.39e-041983634c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell18-Airway-Epithelial|Airway / Age, Tissue, Lineage and Cell class

TEKT1 TMC4 CCDC78

5.39e-04198363be200dc5b9d95c2d37998b29c59418f0ba68d2bb
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 KLF10 GPBP1

5.39e-0419836322559b161e67b49fe8028bfaf861e069063599f5
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SRSF10 ZFC3H1 HERC1

5.46e-04199363f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TEKT1 TMC4 CCDC78

5.46e-041993636aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCell3'_v3-Lung-Myeloid_Monocytic-Classical_monocytes|Lung / Manually curated celltypes from each tissue

CKAP4 KLF10 AOAH

5.46e-04199363bfd0d171ea6bb7abd5cdfeac22608cc190aaa2be
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TEKT1 TMC4 CCDC78

5.46e-0419936360919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellStriatum-Neuronal|Striatum / BrainAtlas - Mouse McCarroll V32

LIN7B CACNB4 HERC1

5.55e-04200363c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCellBiopsy_IPF|World / Sample group, Lineage and Cell type

TEKT1 PSMA6 CCDC78

5.55e-042003634de8c4789fb64250cb1dca94c108d39ab119bab4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Intermediate|1m / Sample Type, Dataset, Time_group, and Cell type.

TAOK3 HERC1 KCNQ4

5.55e-04200363805f50236113713b02f77aa5e208efb3b3b959d5
ToppCellcontrol-Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CKAP4 KLF10 AOAH

5.55e-04200363b5d197472799cc61d7497faed91ac2564ae4930a
ToppCellBiopsy_IPF-Epithelial|Biopsy_IPF / Sample group, Lineage and Cell type

TEKT1 TMC4 CCDC78

5.55e-0420036376f1ac00b34d07057d8da03d276438b719b46b1d
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STOX2 CACNB4 TMC4

5.55e-04200363d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNB4 HERC1 RIMS2

5.55e-0420036348d801219bc771d6c7e151dc88ca4c179988de85
ToppCelldistal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEKT1 LAMC2 CCDC78

5.55e-04200363f5f5a8b0e4d802d95dc42646dd5e7d7daaad72b4
ToppCellBronchus_Control_(B.)-Epithelial-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

LAMC2 TMC4 CCDC78

5.55e-04200363f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ComputationalRNA splicing.

SF3A3 SRSF10 PRPF8

3.90e-0465243MODULE_183
ComputationalNeighborhood of MLL

NUP133 KMT2A GPBP1 PRPF8

5.47e-04174244GCM_MLL
ComputationalSpliceosome.

SF3A3 PRPF8

6.37e-0417242MODULE_388
Diseaseautism spectrum disorder (implicated_via_orthology)

LAMC2 TAOK3 RIMS2 DSCAML1

3.13e-05152354DOID:0060041 (implicated_via_orthology)
DiseaseSmall cell carcinoma of lung

KMT2A TAOK3 RIMS2

3.64e-0554353C0149925
DiseaseHIV Coinfection

SF3A3 PRPF8 PSMA6

2.49e-04103353C4505456
DiseaseHIV Infections

SF3A3 PRPF8 PSMA6

2.49e-04103353C0019693
Diseasesensory peripheral neuropathy, remission

KMT2A CACNB4

3.40e-0423352EFO_0009785, MONDO_0002321
DiseaseS100 calcium-binding protein B measurement

KMT2A NALCN

9.35e-0438352EFO_0600012
Diseasecorpus callosum anterior volume measurement

LAMC2 SND1

9.85e-0439352EFO_0010295
Diseasedisease progression measurement

HERC1 RIMS2

2.39e-0361352EFO_0008336

Protein segments in the cluster

PeptideGeneStartEntry
QVRRSHQDFSRQREE

CKAP4

136

Q07065
YQRENSSYRSQRSSR

CLK2

101

P49760
NYHNERARKSRNRLS

CACNB4

461

O00305
HVYQSSDSIRDRRNS

ARHGEF17

1751

Q96PE2
HRDYQNISRNGASSR

AOAH

331

P28039
HYRQNRNSLYRREES

NUP133

741

Q8WUM0
ARRRQQHQSYSSLES

LIN7B

191

Q9HAP6
TENRYDVNRRRHNSS

GPBP1

36

Q86WP2
LYRSVQAHRNQSRRE

HERC1

2896

Q15751
QRSSAAHKRYRRLQN

KCNQ4

71

P56696
SSGHDRRENLNSYQR

CWC22

11

Q9HCG8
QNERDRISTRRSSYE

HNF4A

131

P41235
AADRQPYHRSRSTEQ

RIMS2

1081

Q9UQ26
REASIRNLARTYHTQ

DSCAML1

1926

Q8TD84
RSREQQLARAARSYH

CCDC78

286

A2IDD5
SILNYQNNSFRRRTH

KLF10

176

Q13118
NESNDRRSRRYSVSE

KMT2A

521

Q03164
RALGSQYQNRVRDTH

LAMC2

706

Q13753
ARAQRSEVRYNQRSQ

nan

366

A6NNC1
RAQRSEVRYNQRSQT

nan

641

A6NNC1
ERYGHNREDSTRNRN

LMBRD2

601

Q68DH5
NASYNREIRHIRNSS

SETX

321

Q7Z333
TVIRYRQDDDQRSSH

SND1

461

Q7KZF4
KNQYHRADAQRSRSE

TEKT1

21

Q969V4
SVQSQALHYRNRERF

TAOK3

421

Q9H2K8
TNTAHYNRERIRRGA

PRPF8

751

Q6P2Q9
DSRSQVQRARYEAAN

PSMA6

86

P60900
RASSRYLELHRSQNR

LINC00173

101

Q6ZV60
RQEYAHRSRETFQQR

ZNF549

206

Q6P9A3
RERNYRSSRQISEDS

SPEN

1241

Q96T58
DNDRFKHRNRSFSRS

SRSF10

161

O75494
HSHTQDRRSRNERSN

STOX2

471

Q9P2F5
RAHRQRNASRDQVVY

TMC4

101

Q7Z404
QINSDHRTRAMQDRY

SF3A3

36

Q12874
QQLRNFSRSRHASER

ZFC3H1

81

O60293
RSYRNRHQQFHTEER

ZNF584

366

Q8IVC4
RRFSQSSALYQHRRV

ZNF764

266

Q96H86
TQDHSNTVRYRNAQR

NALCN

786

Q8IZF0