Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Peptidase_M1	LVRN AOPEP	1.32e-04	12	27	2	IPR001930
Domain	Peptidase_M1	LVRN AOPEP	1.55e-04	13	27	2	PF01433
Domain	Peptidase_M1_N	LVRN AOPEP	1.55e-04	13	27	2	IPR014782
Domain	ZINC_PROTEASE	LVRN AOPEP	8.78e-03	98	27	2	PS00142
Pubmed	A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.	LMO2 RB1	5.80e-06	5	27	2	10866689
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PCNX2 PLEKHM2 DNAH7 AXIN1	3.05e-05	233	27	4	37704626
Pubmed	DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.	XPC RB1	4.45e-04	40	27	2	39328932
Pubmed	DNA sequence and analysis of human chromosome 8.	HGSNAT DOCK5	6.40e-04	48	27	2	16421571
Pubmed	Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.	AMPD2 STXBP1	7.51e-04	52	27	2	20114047
Cytoband	11p13	DCDC1 LMO2	5.03e-04	56	27	2	11p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	DCDC1 LMO2	6.77e-04	65	27	2	chr11p13
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	XPC MTMR14	3.76e-03	155	27	2	chr3p25
Coexpression	GSE26669_CD4_VS_CD8_TCELL_IN_MLR_UP	BYSL STXBP1 RB1 GRHL2	5.03e-05	200	27	4	M4668
Coexpression	GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_DN	DOCK5 DHX32 MTMR14 ACER3	5.03e-05	200	27	4	M7187
Coexpression	GSE17721_LPS_VS_PAM3CSK4_16H_BMDC_DN	HGSNAT DOCK5 SRRT TMEM135	5.03e-05	200	27	4	M3929
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7 AOPEP	5.44e-06	194	27	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	DCDC1 GRHL2 DNAH7	1.02e-04	151	27	3	8216462e723fec2797387929dde095370947e10a
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	AMPD2 ACER3 DNAH7	1.13e-04	156	27	3	abea3c183d32062b009a79a2bdf861021989c7ef
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DCDC1 GRHL2 DNAH7	1.33e-04	165	27	3	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DCDC1 GRHL2 DNAH7	1.33e-04	165	27	3	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	RA-11._Adipocyte\|RA / Chamber and Cluster_Paper	LVRN TMEM135 KLB	1.72e-04	180	27	3	d48a3d27357f7d184132a6805950f93080146b59
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	1.74e-04	181	27	3	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	LVRN TMEM135 KLB	1.80e-04	183	27	3	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	LVRN TMEM135 KLB	1.80e-04	183	27	3	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	COPD-Epithelial-Ciliated\|COPD / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	1.92e-04	187	27	3	f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	LVRN TMEM135 KLB	1.95e-04	188	27	3	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	Control-Epithelial-Ciliated\|Control / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	1.98e-04	189	27	3	c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	1.98e-04	189	27	3	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	2.01e-04	190	27	3	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	2.04e-04	191	27	3	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	2.04e-04	191	27	3	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	10x5'-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	DOCK5 AMPD2 LMO2	2.04e-04	191	27	3	a862a571625ab7238589ff201e5954f602c3bd7e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	2.04e-04	191	27	3	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	Monocytes-Inflammatory_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DOCK5 AMPD2 LMO2	2.08e-04	192	27	3	4be5c2c946337cd3e710137726358adca563f146
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.08e-04	192	27	3	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.08e-04	192	27	3	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.08e-04	192	27	3	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 AMPD2 LMO2	2.08e-04	192	27	3	7bcdbd97fa8c3bfccde426d44979601226913fc3
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STXBP1 ACER3 LMO2	2.14e-04	194	27	3	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.14e-04	194	27	3	958e648138676d46698090b4046cb484083ae449
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STXBP1 ACER3 LMO2	2.14e-04	194	27	3	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.17e-04	195	27	3	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 AMPD2 LMO2	2.17e-04	195	27	3	157f1f9b0521c9eba11806eb4b6802ff116ab912
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Nonclassical_Monocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 AMPD2 LMO2	2.17e-04	195	27	3	95327f2818bcdca53dbd2971f674a9042a1392c6
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.17e-04	195	27	3	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.17e-04	195	27	3	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 AMPD2 LMO2	2.20e-04	196	27	3	29246378ffb1010fe6858da756ae3d13df2306ba
ToppCell	COVID-19_Severe-Non-classical_Monocyte\|COVID-19_Severe / disease group, cell group and cell class	DOCK5 AMPD2 LMO2	2.20e-04	196	27	3	af9e8f5ef9d03862f707e105857309b55595b1b9
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.20e-04	196	27	3	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.20e-04	196	27	3	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	COVID-19_Moderate-Non-classical_Monocyte\|COVID-19_Moderate / disease group, cell group and cell class	DOCK5 AMPD2 LMO2	2.20e-04	196	27	3	256c557fa11414c9d2cbb1fcff33f482ee1c78ac
ToppCell	Influenza_Severe-Non-classical_Monocyte\|World / Disease group and Cell class	DOCK5 AMPD2 LMO2	2.20e-04	196	27	3	8ef9810ee99082a9c803c7ecad6ceb5710d16b54
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DCDC1 GRHL2 DNAH7	2.20e-04	196	27	3	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Healthy/Control-Non-classical_Monocyte\|World / Disease group and Cell class	DOCK5 AMPD2 LMO2	2.24e-04	197	27	3	470784932e1fc3ff69f27cd83f56d85b0c01af63
ToppCell	distal-Hematologic-Platelet/Megakaryocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DCDC1 GRHL2 DNAH7	2.24e-04	197	27	3	e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCell	COVID-19_Severe-Myeloid-Non-classical_Monocyte\|COVID-19_Severe / Disease group, lineage and cell class	DOCK5 AMPD2 LMO2	2.24e-04	197	27	3	c5837b9a5a39a0f607a4e217ade9fc87d82a5406
ToppCell	COVID-19_Severe-Non-classical_Monocyte\|World / disease group, cell group and cell class	DOCK5 AMPD2 LMO2	2.24e-04	197	27	3	60fee75b12451206bb2c07b61651a73c59ec6ade
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC1 GRHL2 DNAH7	2.24e-04	197	27	3	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	distal-Hematologic-Platelet/Megakaryocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DCDC1 GRHL2 DNAH7	2.24e-04	197	27	3	751ffb8792058384079ebfe94872b3525f1aea84
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	9b8679b3dd8f4220d71f607b7080cb88d6e71129
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	8b6b602ebe59b6dca6a22f17385d3160ff3ac67e
ToppCell	Healthy_donor-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	8a97c8b2a43e6d1e669ce18752841e2006744bd9
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	5436c3ed16e10e00c686f1ab0b0a68728a1a9985
ToppCell	COVID-19_Moderate-Non-classical_Monocyte\|World / disease group, cell group and cell class	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	8449934e20bb2a34079fb642cae0d4647b9efe51
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	4f67067d8142ca11b2d80195dac8d62a8d24d52c
ToppCell	Healthy/Control-Non-classical_Monocyte\|Healthy/Control / Disease group and Cell class	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	0badaf1fa5328d06291c3624d0f63196ffc81527
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	b9030390316baf456135f85f831394e1e11ecf3e
ToppCell	PBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DOCK5 AMPD2 LMO2	2.27e-04	198	27	3	d36a3cda7e5f385d2391e9b0dfb027d3c4549320
ToppCell	Control-Control-Myeloid-CD16+_Monocyte\|Control / Disease, condition lineage and cell class	DOCK5 AMPD2 LMO2	2.34e-04	200	27	3	8dd124a5aca897652ea68efbfc5a167b4cf31aef
ToppCell	mild-Non-classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DOCK5 AMPD2 LMO2	2.34e-04	200	27	3	334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCell	Influenza-Influenza_Severe-Myeloid-CD16+_Monocyte\|Influenza_Severe / Disease, condition lineage and cell class	DOCK5 AMPD2 LMO2	2.34e-04	200	27	3	1efdcfcd86e99fbe03db19a2a5ab10808eec282d
ToppCell	COVID-19-COVID-19_Severe-Myeloid-CD16+_Monocyte\|COVID-19_Severe / Disease, condition lineage and cell class	DOCK5 AMPD2 LMO2	2.34e-04	200	27	3	58fbb7fc7159cbc417e6b457d60b7beba9b90da6
ToppCell	Control-Control-Myeloid-cDC\|Control / Disease, condition lineage and cell class	MTMR14 ACER3 LMO2	2.34e-04	200	27	3	1375d199320feb85ba06e74b10df6521e790addf
Disease	Non-Small Cell Lung Carcinoma	XPC RB1 TMEM135	3.45e-04	156	26	3	C0007131
Disease	urinary bladder cancer (is_implicated_in)	RB1 AXIN1	2.04e-03	76	26	2	DOID:11054 (is_implicated_in)
Disease	Glioblastoma	SRRT TMEM135	2.21e-03	79	26	2	C0017636
Disease	Giant Cell Glioblastoma	SRRT TMEM135	2.49e-03	84	26	2	C0334588
Disease	mean corpuscular hemoglobin concentration	BYSL COPS4 DHX32 LMO2 AXIN1	2.49e-03	1105	26	5	EFO_0004528

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYTRTLYLRYRPKVK	ACER3	236	Q9NUN7
LILILYYKIYRAAKT	HTR1F	196	P30939
YLKGYFLLRFLAKRL	AOPEP	586	Q8N6M6
LLLRKAPVLQYLYYL	AMPD2	711	Q01433
IYDIYSLLKRYLLKR	LVRN	741	Q6Q4G3
LPYSSRYYKLLKERE	DHX32	46	Q7L7V1
LYYKLGRKLCRRDYL	LMO2	71	P25791
SLSLFYKKVYRLAYL	RB1	646	P06400
YKKVYRLAYLRLNTL	RB1	651	P06400
KKPIILVYLRYAYSL	OTUD6A	251	Q7L8S5
LLALYQRLKSAKKYY	DCDC1	391	M0R2J8
RGYDIKLLRYLSVKY	MTMR14	196	Q8NCE2
LAVKKYFRRITLYLT	IFNA1;	141	P01562
RRILIRYYIKSIIYY	PCNX2	1526	A6NKB5
VDYKLETYLKIARLY	COPS4	141	Q9BT78
LLYDYYKVPRDKRLL	GRHL2	66	Q6ISB3
REDIYIRYLYKLRDL	DOCK5	1236	Q9H7D0
LLKYLVYILRKAARR	CACNA1G	436	O43497
KRLKLARAIYRKYIL	AXIN1	136	O15169
LRLYDKYDFLITRKA	DNAH7	491	Q8WXX0
RLRKYYLGKYLQEVL	KLB	901	Q86Z14
LLYYKARTKDILIRF	HGSNAT	521	Q68CP4
FLRLLLDKKYALPYR	BYSL	341	Q13895
LYVLLTDCYVYLLRK	PLEKHM2	626	Q8IWE5
TYDKIRIILLYIFLK	STXBP1	401	P61764
KLLLYLRIVHSLDYY	SRRT	611	Q9BXP5
YLIAAILRKRKLDYY	TMEM135	46	Q86UB9
ILRKRKLDYYLHKLL	TMEM135	51	Q86UB9
IVKRLQLKYAIYAYR	ZPBP	151	Q9BS86
LYALKRHLLKYEAIY	XPC	646	Q01831