Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytidine deaminase activity

APOBEC3D APOBEC3H APOBEC3F

1.65e-0613373GO:0004126
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR3

2.00e-054372GO:0005219
GeneOntologyMolecularFunctiondeaminase activity

APOBEC3D APOBEC3H APOBEC3F

3.37e-0534373GO:0019239
GeneOntologyMolecularFunctionWnt-protein binding

FZD9 SFRP2 FZD3

3.37e-0534373GO:0017147
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

APOBEC3D APOBEC3H APOBEC3F

4.01e-0536373GO:0016814
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR3

4.99e-056372GO:0048763
GeneOntologyMolecularFunctionWnt receptor activity

FZD9 FZD3

4.46e-0417372GO:0042813
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR3

5.02e-0418372GO:0015278
GeneOntologyMolecularFunctionphosphatidylinositol phospholipase C activity

PLCG1 PLCG2

1.06e-0326372GO:0004435
GeneOntologyMolecularFunctionphospholipase C activity

PLCG1 PLCG2

1.31e-0329372GO:0004629
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR3

1.50e-0331372GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR3

1.70e-0333372GO:0005217
GeneOntologyMolecularFunctioncalcium channel activity

PKDREJ RYR1 RYR3

1.74e-03129373GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

P2RX7 RYR1 RYR3

2.20e-03140373GO:0099094
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

APOBEC3D APOBEC3H APOBEC3F

2.48e-03146373GO:0016810
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

PKDREJ RYR1 RYR3

2.73e-03151373GO:0015085
GeneOntologyMolecularFunctionmonoatomic cation channel activity

P2RX7 PKDREJ RYR1 RYR3

3.61e-03343374GO:0005261
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

P2RX7 RYR1 RYR3

5.42e-03193373GO:0015276
GeneOntologyMolecularFunctionzinc ion binding

APOBEC3D RNF31 P2RX7 NQO2 APOBEC3H APOBEC3F

5.52e-03891376GO:0008270
GeneOntologyMolecularFunctionligand-gated channel activity

P2RX7 RYR1 RYR3

5.74e-03197373GO:0022834
GeneOntologyMolecularFunctionmodification-dependent protein binding

PLCG2 RNF31 ING1

6.50e-03206373GO:0140030
GeneOntologyBiologicalProcessclearance of foreign intracellular DNA

APOBEC3D APOBEC3H APOBEC3F

1.06e-076373GO:0044355
GeneOntologyBiologicalProcessclearance of foreign intracellular nucleic acids

APOBEC3D APOBEC3H APOBEC3F

1.06e-076373GO:0099046
GeneOntologyBiologicalProcessDNA cytosine deamination

APOBEC3D APOBEC3H APOBEC3F

6.32e-0710373GO:0070383
GeneOntologyBiologicalProcessresponse to ATP

PLCG2 P2RX7 RYR1 RYR3

7.65e-0740374GO:0033198
GeneOntologyBiologicalProcesscytidine to uridine editing

APOBEC3D APOBEC3H APOBEC3F

1.16e-0612373GO:0016554
GeneOntologyBiologicalProcesscytidine metabolic process

APOBEC3D APOBEC3H APOBEC3F

1.91e-0614373GO:0046087
GeneOntologyBiologicalProcesscytidine catabolic process

APOBEC3D APOBEC3H APOBEC3F

1.91e-0614373GO:0006216
GeneOntologyBiologicalProcesscytidine deamination

APOBEC3D APOBEC3H APOBEC3F

1.91e-0614373GO:0009972
GeneOntologyBiologicalProcessDNA deamination

APOBEC3D APOBEC3H APOBEC3F

1.91e-0614373GO:0045006
GeneOntologyBiologicalProcessnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3D APOBEC3H APOBEC3F

2.93e-0616373GO:0045869
GeneOntologyBiologicalProcesspyrimidine ribonucleoside metabolic process

APOBEC3D APOBEC3H APOBEC3F

2.93e-0616373GO:0046131
GeneOntologyBiologicalProcesspyrimidine ribonucleoside catabolic process

APOBEC3D APOBEC3H APOBEC3F

2.93e-0616373GO:0046133
GeneOntologyBiologicalProcesspyrimidine nucleoside catabolic process

APOBEC3D APOBEC3H APOBEC3F

4.26e-0618373GO:0046135
GeneOntologyBiologicalProcessregulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3D APOBEC3H APOBEC3F

5.05e-0619373GO:0045091
GeneOntologyBiologicalProcessbase conversion or substitution editing

APOBEC3D APOBEC3H APOBEC3F

5.05e-0619373GO:0016553
GeneOntologyBiologicalProcesssingle stranded viral RNA replication via double stranded DNA intermediate

APOBEC3D APOBEC3H APOBEC3F

5.93e-0620373GO:0039692
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

PLCG1 PLCG2 P2RX7 RYR1 RYR3

6.03e-06146375GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

PLCG1 PLCG2 P2RX7 RYR1 RYR3

6.23e-06147375GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

PLCG1 PLCG2 P2RX7 RYR1 RYR3

6.65e-06149375GO:0051282
GeneOntologyBiologicalProcesscellular response to ATP

P2RX7 RYR1 RYR3

6.91e-0621373GO:0071318
GeneOntologyBiologicalProcesssequestering of calcium ion

PLCG1 PLCG2 P2RX7 RYR1 RYR3

7.57e-06153375GO:0051208
GeneOntologyBiologicalProcessribonucleoside catabolic process

APOBEC3D APOBEC3H APOBEC3F

1.34e-0526373GO:0042454
GeneOntologyBiologicalProcesspyrimidine nucleoside metabolic process

APOBEC3D APOBEC3H APOBEC3F

1.51e-0527373GO:0006213
GeneOntologyBiologicalProcessDNA modification

APOBEC3D APOBEC3H APOBEC3F

2.31e-0531373GO:0006304
GeneOntologyBiologicalProcessviral RNA genome replication

APOBEC3D APOBEC3H APOBEC3F

2.54e-0532373GO:0039694
GeneOntologyBiologicalProcessnucleoside catabolic process

APOBEC3D APOBEC3H APOBEC3F

2.54e-0532373GO:0009164
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

FZD9 PLCG1 PLCG2 P2RX7 RYR1 RYR3

3.93e-05359376GO:0006874
GeneOntologyBiologicalProcessnucleobase-containing small molecule catabolic process

APOBEC3D APOBEC3H APOBEC3F

3.96e-0537373GO:0034656
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

PLCG1 PLCG2 P2RX7 RYR1 RYR3

4.08e-05217375GO:0097553
GeneOntologyBiologicalProcessglycosyl compound catabolic process

APOBEC3D APOBEC3H APOBEC3F

5.40e-0541373GO:1901658
GeneOntologyBiologicalProcesscalcium ion homeostasis

FZD9 PLCG1 PLCG2 P2RX7 RYR1 RYR3

6.14e-05389376GO:0055074
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

PLCG1 PLCG2 P2RX7 PKDREJ RYR1 RYR3

6.40e-05392376GO:0070588
GeneOntologyBiologicalProcesspyrimidine-containing compound catabolic process

APOBEC3D APOBEC3H APOBEC3F

7.65e-0546373GO:0072529
GeneOntologyBiologicalProcesstransposable element silencing

APOBEC3D APOBEC3H APOBEC3F

7.65e-0546373GO:0010526
GeneOntologyBiologicalProcessribonucleoside metabolic process

APOBEC3D APOBEC3H APOBEC3F

8.69e-0548373GO:0009119
GeneOntologyBiologicalProcessretrotransposition

APOBEC3D APOBEC3H APOBEC3F

8.69e-0548373GO:0032197
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

9.19e-05611377GO:0030003
GeneOntologyBiologicalProcessmaintenance of location in cell

PLCG1 PLCG2 P2RX7 RYR1 RYR3

9.43e-05259375GO:0051651
GeneOntologyBiologicalProcesstransposition

APOBEC3D APOBEC3H APOBEC3F

9.83e-0550373GO:0032196
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

1.03e-04622377GO:0006873
GeneOntologyBiologicalProcesscalcium-mediated signaling

PLCG1 PLCG2 P2RX7 RYR1 RYR3

1.07e-04266375GO:0019722
GeneOntologyBiologicalProcesssympathetic ganglion development

FZD3 NRP2

1.12e-049372GO:0061549
GeneOntologyBiologicalProcessresponse to organophosphorus

PLCG2 P2RX7 RYR1 RYR3

1.19e-04142374GO:0046683
GeneOntologyBiologicalProcessnegative regulation of viral genome replication

APOBEC3D APOBEC3H APOBEC3F

1.38e-0456373GO:0045071
GeneOntologyBiologicalProcessinositol trisphosphate biosynthetic process

PLCG1 PLCG2

1.70e-0411372GO:0032959
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR3

1.70e-0411372GO:0071313
GeneOntologyBiologicalProcessresponse to calcium ion

PLCG2 P2RX7 RYR1 RYR3

1.93e-04161374GO:0051592
GeneOntologyBiologicalProcessresponse to purine-containing compound

PLCG2 P2RX7 RYR1 RYR3

2.17e-04166374GO:0014074
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

2.23e-04705377GO:0055080
GeneOntologyBiologicalProcessnucleoside metabolic process

APOBEC3D APOBEC3H APOBEC3F

2.46e-0468373GO:0009116
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

2.47e-04717377GO:0050801
GeneOntologyBiologicalProcesscalcium ion transport

PLCG1 PLCG2 P2RX7 PKDREJ RYR1 RYR3

2.66e-04509376GO:0006816
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR3

2.81e-0414372GO:0071415
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

FZD9 SFRP2 FZD3

3.55e-0477373GO:0035567
GeneOntologyBiologicalProcessinositol trisphosphate metabolic process

PLCG1 PLCG2

4.19e-0417372GO:0032957
GeneOntologyBiologicalProcessganglion development

FZD3 NRP2

4.70e-0418372GO:0061548
GeneOntologyBiologicalProcesscellular response to calcium ion

PLCG2 RYR1 RYR3

5.25e-0488373GO:0071277
GeneOntologyBiologicalProcessregulation of viral genome replication

APOBEC3D APOBEC3H APOBEC3F

5.79e-0491373GO:0045069
GeneOntologyBiologicalProcesspyrimidine-containing compound metabolic process

APOBEC3D APOBEC3H APOBEC3F

5.98e-0492373GO:0072527
GeneOntologyBiologicalProcessoutflow tract morphogenesis

SFRP2 RYR1 NRP2

6.37e-0494373GO:0003151
GeneOntologyBiologicalProcessresponse to caffeine

RYR1 RYR3

6.44e-0421372GO:0031000
GeneOntologyBiologicalProcessmaintenance of location

PLCG1 PLCG2 P2RX7 RYR1 RYR3

6.69e-04396375GO:0051235
GeneOntologyBiologicalProcessglycosyl compound metabolic process

APOBEC3D APOBEC3H APOBEC3F

6.77e-0496373GO:1901657
GeneOntologyBiologicalProcessintracellular chemical homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

7.67e-04866377GO:0055082
GeneOntologyBiologicalProcessinorganic ion homeostasis

FZD9 PLCG1 PLCG2 P2RX7 RYR1 RYR3

7.69e-04622376GO:0098771
GeneOntologyBiologicalProcessnegative regulation of viral process

APOBEC3D APOBEC3H APOBEC3F

8.31e-04103373GO:0048525
GeneOntologyBiologicalProcessphosphatidylinositol-mediated signaling

PLCG1 PLCG2

8.43e-0424372GO:0048015
GeneOntologyBiologicalProcesssympathetic nervous system development

FZD3 NRP2

8.43e-0424372GO:0048485
GeneOntologyBiologicalProcessnegative regulation of necroptotic process

FZD9 RNF31

8.43e-0424372GO:0060546
GeneOntologyBiologicalProcessresponse to magnesium ion

PLCG2 RYR3

9.15e-0425372GO:0032026
GeneOntologyBiologicalProcessFc-epsilon receptor signaling pathway

PLCG1 PLCG2

9.15e-0425372GO:0038095
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport

PLCG1 PLCG2 P2RX7

9.79e-04109373GO:1904427
GeneOntologyBiologicalProcessnegative regulation of programmed necrotic cell death

FZD9 RNF31

9.90e-0426372GO:0062099
GeneOntologyBiologicalProcessregulation of mitochondrial depolarization

FZD9 P2RX7

1.07e-0327372GO:0051900
GeneOntologyBiologicalProcesspost-anal tail morphogenesis

SFRP2 FZD3

1.23e-0329372GO:0036342
GeneOntologyBiologicalProcessinositol phosphate biosynthetic process

PLCG1 PLCG2

1.41e-0331372GO:0032958
GeneOntologyBiologicalProcesscellular homeostasis

FZD9 PLCG1 PLCG2 P2RX7 CLN5 RYR1 RYR3

1.59e-03981377GO:0019725
GeneOntologyBiologicalProcesspositive regulation of macrophage cytokine production

PLCG2 P2RX7

1.60e-0333372GO:0060907
GeneOntologyBiologicalProcessmitochondrial depolarization

FZD9 P2RX7

1.79e-0335372GO:0051882
GeneOntologyBiologicalProcessviral genome replication

APOBEC3D APOBEC3H APOBEC3F

1.89e-03137373GO:0019079
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

RYR1 RYR3

2.00e-0337372GO:0014808
GeneOntologyBiologicalProcessregulation of necroptotic process

FZD9 RNF31

2.00e-0337372GO:0060544
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

RYR1 RYR3

2.23e-0339372GO:1903514
GeneOntologyBiologicalProcesscellular response to alkaloid

RYR1 RYR3

2.34e-0340372GO:0071312
GeneOntologyBiologicalProcessheart morphogenesis

SFRP2 NSD2 RYR1 NRP2

2.54e-03321374GO:0003007
GeneOntologyBiologicalProcesscarbohydrate derivative catabolic process

APOBEC3D P2RX7 APOBEC3H APOBEC3F

2.59e-03323374GO:1901136
GeneOntologyBiologicalProcesspositive regulation of calcium ion transport

PLCG1 PLCG2 P2RX7

2.63e-03154373GO:0051928
GeneOntologyBiologicalProcessregulation of programmed necrotic cell death

FZD9 RNF31

2.70e-0343372GO:0062098
GeneOntologyBiologicalProcessregulation of viral life cycle

APOBEC3D APOBEC3H APOBEC3F

2.73e-03156373GO:1903900
GeneOntologyBiologicalProcessestablishment of planar polarity

SFRP2 FZD3

2.82e-0344372GO:0001736
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

RYR1 RYR3

2.82e-0344372GO:0070296
GeneOntologyBiologicalProcesspositive regulation of production of molecular mediator of immune response

PLCG2 P2RX7 NSD2

2.83e-03158373GO:0002702
GeneOntologyBiologicalProcessT cell receptor signaling pathway

PLCG1 PLCG2 RNF31

2.93e-03160373GO:0050852
GeneOntologyBiologicalProcessestablishment of tissue polarity

SFRP2 FZD3

2.95e-0345372GO:0007164
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

SFRP2 NSD2 NRP2

2.99e-03161373GO:0003206
GeneOntologyBiologicalProcesspositive regulation of myeloid leukocyte cytokine production involved in immune response

PLCG2 P2RX7

3.08e-0346372GO:0061081
GeneOntologyBiologicalProcessregulation of macrophage cytokine production

PLCG2 P2RX7

3.35e-0348372GO:0010935
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

1.09e-049372GO:0030314
DomainAPOBEC_N

APOBEC3D APOBEC3H APOBEC3F

1.56e-0612373PF08210
DomainAPOBEC_N

APOBEC3D APOBEC3H APOBEC3F

1.56e-0612373IPR013158
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3D APOBEC3H APOBEC3F

2.57e-0614373IPR016192
DomainPLC-gamma

PLCG1 PLCG2

3.82e-062372IPR016279
DomainFrizzled/SFRP

FZD9 SFRP2 FZD3

3.94e-0616373IPR015526
DomainCYT_DCMP_DEAMINASES_1

APOBEC3D APOBEC3H APOBEC3F

4.77e-0617373PS00903
DomainCMP_dCMP_Zn-bd

APOBEC3D APOBEC3H APOBEC3F

4.77e-0617373IPR002125
DomainCytidine_deaminase-like

APOBEC3D APOBEC3H APOBEC3F

4.77e-0617373IPR016193
DomainFRI

FZD9 SFRP2 FZD3

7.97e-0620373SM00063
Domain-

FZD9 SFRP2 FZD3

9.29e-06213731.10.2000.10
DomainRyR

RYR1 RYR3

1.14e-053372PF02026
DomainRyanodine_rcpt

RYR1 RYR3

1.14e-053372IPR003032
DomainRR_TM4-6

RYR1 RYR3

1.14e-053372PF06459
DomainRyanrecept_TM4-6

RYR1 RYR3

1.14e-053372IPR009460
DomainRyan_recept

RYR1 RYR3

1.14e-053372IPR013333
DomainFrizzled_dom

FZD9 SFRP2 FZD3

1.41e-0524373IPR020067
DomainFZ

FZD9 SFRP2 FZD3

1.41e-0524373PS50038
DomainFz

FZD9 SFRP2 FZD3

1.41e-0524373PF01392
DomainRIH_assoc

RYR1 RYR3

5.70e-056372PF08454
DomainRIH_assoc-dom

RYR1 RYR3

5.70e-056372IPR013662
DomainRYDR_ITPR

RYR1 RYR3

5.70e-056372PF01365
DomainRIH_dom

RYR1 RYR3

5.70e-056372IPR000699
DomainIns145_P3_rcpt

RYR1 RYR3

5.70e-056372IPR014821
DomainRyanodine_recept-rel

RYR1 RYR3

5.70e-056372IPR015925
DomainIns145_P3_rec

RYR1 RYR3

5.70e-056372PF08709
Domain-

RYR1 RYR3

5.70e-0563721.25.10.30
DomainMIR

RYR1 RYR3

1.70e-0410372PS50919
DomainMIR

RYR1 RYR3

1.70e-0410372PF02815
DomainMIR

RYR1 RYR3

1.70e-0410372SM00472
DomainMIR_motif

RYR1 RYR3

1.70e-0410372IPR016093
DomainFrizzled

FZD9 FZD3

2.08e-0411372IPR000539
DomainFrizzled

FZD9 FZD3

2.08e-0411372PF01534
DomainFrizzled

FZD9 FZD3

2.08e-0411372SM01330
DomainPIPLC_Y_DOMAIN

PLCG1 PLCG2

3.95e-0415372PS50008
DomainPI-PLC_fam

PLCG1 PLCG2

3.95e-0415372IPR001192
DomainPLC_EF-hand-like

PLCG1 PLCG2

3.95e-0415372IPR015359
DomainPI-PLC-Y

PLCG1 PLCG2

3.95e-0415372PF00387
DomainCYT_DCMP_DEAMINASES_2

APOBEC3H APOBEC3F

3.95e-0415372PS51747
DomainPLipase_C_Pinositol-sp_Y

PLCG1 PLCG2

3.95e-0415372IPR001711
DomainEF-hand_like

PLCG1 PLCG2

3.95e-0415372PF09279
DomainPLCYc

PLCG1 PLCG2

3.95e-0415372SM00149
DomainPI-PLC-X

PLCG1 PLCG2

5.73e-0418372PF00388
DomainPLCXc

PLCG1 PLCG2

5.73e-0418372SM00148
DomainPIPLC_X_DOMAIN

PLCG1 PLCG2

6.39e-0419372PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCG1 PLCG2

6.39e-0419372IPR000909
DomainSH2

PLCG1 PLCG2 SH2D5

1.04e-03101373PF00017
Domain-

PLCG1 PLCG2

1.11e-03253723.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCG1 PLCG2

1.11e-0325372IPR017946
DomainSH2

PLCG1 PLCG2 SH2D5

1.33e-03110373SM00252
DomainSH2

PLCG1 PLCG2 SH2D5

1.37e-03111373PS50001
DomainSH2

PLCG1 PLCG2 SH2D5

1.41e-03112373IPR000980
Domain-

PLCG1 PLCG2 SH2D5

1.41e-031123733.30.505.10
DomainEF-hand-dom_pair

PLCG1 PLCG2 RYR1 RYR3

2.42e-03287374IPR011992
DomainGPCR_2-like

FZD9 FZD3

6.29e-0360372IPR017981
DomainGPCR_2_secretin-like

FZD9 FZD3

6.29e-0360372IPR000832
DomainG_PROTEIN_RECEP_F2_4

FZD9 FZD3

6.49e-0361372PS50261
DomainZinc_finger_PHD-type_CS

ING1 NSD2

7.34e-0365372IPR019786
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

PLCG1 PLCG2 P2RX7 RYR1 RYR3

1.06e-05178245M2890
PathwayREACTOME_MRNA_EDITING_C_TO_U_CONVERSION

APOBEC3D APOBEC3F

5.80e-057242MM15412
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOLIPASE_C_GAMMA_PLCG

PLCG1 PLCG2

5.80e-057242M27906
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY

PLCG1 PLCG2

7.73e-058242M47479
PathwayREACTOME_MRNA_EDITING

APOBEC3D APOBEC3F

9.93e-059242MM15445
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

PLCG1 PLCG2 RYR1 RYR3

1.23e-04154244MM15974
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

PLCG1 PLCG2 RYR1 RYR3

1.29e-04156244M39475
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR3

1.51e-0411242M47958
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FZD9 PLCG1 FZD3

1.85e-0466243M39642
PathwayWP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS

PLCG1 RYR3

2.14e-0413242M39463
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR3

2.14e-0413242M39589
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.50e-0414242M47386
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.50e-0414242M47388
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.50e-0414242M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.50e-0414242M47384
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD9 FZD3

2.50e-0414242M47834
PathwayWP_GPR40_PATHWAY

PLCG1 PLCG2

2.88e-0415242M39526
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CAMK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.88e-0415242M47385
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 PLCG2

2.88e-0415242M47382
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PLCG1 PLCG2

3.29e-0416242M47449
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD9 FZD3

3.29e-0416242M47823
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PLCG_CAMK_SIGNALING_PATHWAY

PLCG1 PLCG2

3.72e-0417242M47387
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

PLCG1 PLCG2

3.72e-0417242M47560
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

FZD9 PLCG2 FZD3

3.91e-0485243M48315
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

FZD9 SFRP2 FZD3

4.47e-0489243M39563
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

PLCG1 PLCG2

4.67e-0419242M47596
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR3

4.67e-0419242M47760
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD9 FZD3

4.67e-0419242M47833
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

PLCG1 PLCG2

4.67e-0419242M47733
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

PLCG1 CABIN1

5.18e-0420242M48330
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCG1 PLCG2

5.72e-0421242M47542
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

FZD9 SFRP2 FZD3

5.93e-0498243M39731
PathwayREACTOME_SIGNALING_BY_ERYTHROPOIETIN

PLCG1 PLCG2

8.14e-0425242M27865
PathwayPID_VEGFR1_PATHWAY

PLCG1 NRP2

8.81e-0426242M226
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCG1 PLCG2

8.81e-0426242M27053
PathwayWP_WNT_SIGNALING_WP428

FZD9 SFRP2 FZD3

8.98e-04113243M39669
PathwayREACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES

PLCG1 PLCG2

9.50e-0427242MM14809
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCG1 PLCG2

1.02e-0328242MM14711
PathwayREACTOME_DAP12_SIGNALING

PLCG1 PLCG2

1.10e-0329242M27171
PathwayPID_AR_NONGENOMIC_PATHWAY

PLCG1 PLCG2

1.25e-0331242M213
PathwayREACTOME_DAP12_SIGNALING

PLCG1 PLCG2

1.25e-0331242MM14886
PathwayWP_4P163_COPY_NUMBER_VARIATION

PLCG1 NSD2

1.34e-0332242M48083
PathwayPID_EPO_PATHWAY

PLCG1 PLCG2

1.42e-0333242M233
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

PLCG1 PLCG2

1.42e-0333242M39745
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD9 FZD3

1.69e-0336242M39699
PathwayREACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES

PLCG1 PLCG2

1.98e-0339242M16523
PathwayKEGG_PATHWAYS_IN_CANCER

FZD9 PLCG1 PLCG2 FZD3

2.05e-03325244M12868
PathwayKEGG_WNT_SIGNALING_PATHWAY

FZD9 SFRP2 FZD3

2.07e-03151243M19428
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FZD9 FZD3 NRP2

2.48e-03161243M39770
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD9 FZD3

2.52e-0344242MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD9 FZD3

2.63e-0345242M47412
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PLCG1 PLCG2

2.75e-0346242M48317
PathwayREACTOME_DAP12_INTERACTIONS

PLCG1 PLCG2

2.75e-0346242M27151
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD9 FZD3

2.75e-0346242M47409
PathwayPID_PI3KCI_PATHWAY

PLCG1 PLCG2

2.99e-0348242M141
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCG1 PLCG2

2.99e-0348242MM14589
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCG1 PLCG2

2.99e-0348242M26964
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PLCG1 PLCG2

3.11e-0349242M40046
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PLCG1 PLCG2

3.77e-0354242M3896
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR3

3.77e-0354242M27460
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

PLCG1 PLCG2

3.77e-0354242M19818
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR3

3.77e-0354242MM15202
PathwayREACTOME_DAP12_INTERACTIONS

PLCG1 PLCG2

3.77e-0354242MM14871
PathwayKEGG_VIBRIO_CHOLERAE_INFECTION

PLCG1 PLCG2

3.77e-0354242M17906
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD9 FZD3

3.90e-0355242M17807
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

PLCG1 PLCG2

3.90e-0355242M47952
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

PLCG1 PLCG2

4.04e-0356242MM14815
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

PLCG1 PLCG2

4.33e-0358242MM14914
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

PLCG1 PLCG2

4.63e-0360242MM14913
PathwayWP_WNT_SIGNALING

FZD9 FZD3

4.78e-0361242MM15893
PathwayKEGG_GLIOMA

PLCG1 PLCG2

5.41e-0365242M1835
PathwayREACTOME_LEISHMANIA_INFECTION

PLCG1 PLCG2 P2RX7

5.88e-03219243M29836
PathwayKEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION

PLCG1 PLCG2

5.91e-0368242M16848
PathwayWP_NONSMALL_CELL_LUNG_CANCER

PLCG1 PLCG2

6.60e-0372242M39738
PathwayWP_LEPTIN_SIGNALING

PLCG1 PLCG2

7.33e-0376242M39491
PathwayKEGG_VEGF_SIGNALING_PATHWAY

PLCG1 PLCG2

7.33e-0376242M1749
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PLCG1 PLCG2

7.33e-0376242M9052
Pubmed

APOBEC3 proteins can copackage and comutate HIV-1 genomes.

APOBEC3D APOBEC3H APOBEC3F

4.43e-09437327439715
Pubmed

CEM-T4 cells do not lack an APOBEC3G cofactor.

APOBEC3D APOBEC3H APOBEC3F

4.43e-09437319649317
Pubmed

A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR.

APOBEC3D APOBEC3H APOBEC3F

4.43e-09437319344514
Pubmed

Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities.

APOBEC3D APOBEC3H APOBEC3F

4.43e-09437322203821
Pubmed

Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.

PLCG1 PLCG2 P2RX7

4.43e-09437320070863
Pubmed

APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages.

APOBEC3D APOBEC3H APOBEC3F

4.43e-09437323097438
Pubmed

A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.

APOBEC3D APOBEC3H APOBEC3F

1.11e-08537325461536
Pubmed

Suppression of APOBEC3-mediated restriction of HIV-1 by Vif.

APOBEC3D APOBEC3H APOBEC3F

1.11e-08537325206352
Pubmed

AID and APOBECs span the gap between innate and adaptive immunity.

APOBEC3D APOBEC3H APOBEC3F

1.11e-08537325352838
Pubmed

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors.

APOBEC3D APOBEC3H APOBEC3F

2.21e-08637322205746
Pubmed

Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.

APOBEC3D APOBEC3H APOBEC3F

2.21e-08637322912627
Pubmed

APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.

APOBEC3D APOBEC3H APOBEC3F

2.21e-08637322720156
Pubmed

Structure-guided analysis of the human APOBEC3-HIV restrictome.

APOBEC3D APOBEC3H APOBEC3F

2.21e-08637324657093
Pubmed

The restriction factors of human immunodeficiency virus.

APOBEC3D APOBEC3H APOBEC3F

3.87e-08737323043100
Pubmed

APOBEC3 proteins mediate the clearance of foreign DNA from human cells.

APOBEC3D APOBEC3H APOBEC3F

3.87e-08737320062055
Pubmed

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

APOBEC3D APOBEC3H APOBEC3F

3.87e-08737321835787
Pubmed

APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.

APOBEC3D APOBEC3H APOBEC3F

6.18e-08837324227842
Pubmed

The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation.

APOBEC3D APOBEC3H APOBEC3F

9.27e-08937325408426
Pubmed

Introduction to thematic minireview series: Understanding human immunodeficiency virus-host interactions at the biochemical level.

APOBEC3D APOBEC3H APOBEC3F

1.32e-071037323043103
Pubmed

Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS.

APOBEC3D APOBEC3H APOBEC3F

1.32e-071037320174454
Pubmed

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

APOBEC3D APOBEC3H APOBEC3F

1.82e-071137312683974
Pubmed

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

APOBEC3D APOBEC3H APOBEC3F

1.82e-071137322915799
Pubmed

Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437335665767
Pubmed

Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437333688799
Pubmed

Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437324424947
Pubmed

The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437336787309
Pubmed

Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437338967302
Pubmed

Noradrenergic circuit control of non-REM sleep substates.

APOBEC3D P2RX7 APOBEC3F

4.00e-071437334648731
Pubmed

Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537335719268
Pubmed

Activation of neuronal Ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and axonal plasticity in mice.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537332964455
Pubmed

δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537337707499
Pubmed

AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537336873496
Pubmed

Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537338812551
Pubmed

Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537337883185
Pubmed

ERG K+ channels mediate a major component of action potential repolarization in lymphatic muscle.

APOBEC3D P2RX7 APOBEC3F

5.00e-071537337689781
Pubmed

Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.

APOBEC3D P2RX7 APOBEC3F

6.15e-071637336049479
Pubmed

Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.

APOBEC3D P2RX7 APOBEC3F

6.15e-071637333904407
Pubmed

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.

APOBEC3D P2RX7 APOBEC3F

7.46e-071737330995469
Pubmed

A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.

APOBEC3D P2RX7 APOBEC3F

7.46e-071737337034992
Pubmed

The bone microenvironment invigorates metastatic seeds for further dissemination.

APOBEC3D P2RX7 APOBEC3F

7.46e-071737333878291
Pubmed

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

APOBEC3D APOBEC3H APOBEC3F

7.46e-071737324189052
Pubmed

Movement-related increases in subthalamic activity optimize locomotion.

APOBEC3D P2RX7 APOBEC3F

7.46e-071737339068661
Pubmed

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.

APOBEC3D APOBEC3H APOBEC3F

8.94e-071837320096141
Pubmed

Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.

APOBEC3D P2RX7 APOBEC3F

8.94e-071837337914931
Pubmed

Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.

RYR1 RYR3

1.10e-06237215894801
Pubmed

Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1.

PLCG1 PLCG2

1.10e-06237225793864
Pubmed

Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R.

PLCG1 PLCG2

1.10e-06237212471105
Pubmed

Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin.

PLCG1 PLCG2

1.10e-0623728615781
Pubmed

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.

RYR1 RYR3

1.10e-0623729799464
Pubmed

Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.

RYR1 RYR3

1.10e-0623729817784
Pubmed

Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.

RYR1 RYR3

1.10e-06237212565913
Pubmed

Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.10e-0623729489997
Pubmed

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.10e-0623729192302
Pubmed

The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.

RYR1 RYR3

1.10e-06237212640042
Pubmed

Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.

APOBEC3D APOBEC3H

1.10e-06237223755966
Pubmed

Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

RYR1 RYR3

1.10e-0623727556644
Pubmed

The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.

PLCG1 PLCG2

1.10e-06237215972651
Pubmed

Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.

RYR1 RYR3

1.10e-06237214592949
Pubmed

Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.

RYR1 RYR3

1.10e-06237217118445
Pubmed

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

RYR1 RYR3

1.10e-06237211500519
Pubmed

Motor neurons with axial muscle projections specified by Wnt4/5 signaling.

FZD9 SFRP2 FZD3

1.68e-062237319285468
Pubmed

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

APOBEC3D P2RX7 APOBEC3F

1.93e-062337334473953
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD9 SFRP2 FZD3

2.51e-062537312812787
Pubmed

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.

FZD9 SFRP2 FZD3

3.19e-062737317804636
Pubmed

The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G, APOBEC3F, and APOBEC3H.

APOBEC3H APOBEC3F

3.30e-06337222013041
Pubmed

Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.

APOBEC3D APOBEC3F

3.30e-06337232641479
Pubmed

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.

APOBEC3D APOBEC3F

3.30e-06337227602762
Pubmed

Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.

PLCG1 PLCG2

3.30e-06337217015722
Pubmed

Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.

APOBEC3D APOBEC3F

3.30e-063372286744
Pubmed

Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor.

PLCG1 PLCG2

3.30e-06337211331309
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR3

3.30e-0633729242641
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR3

3.30e-06337218403125
Pubmed

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.

RYR1 RYR3

3.30e-06337211171121
Pubmed

A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.

APOBEC3D APOBEC3F

3.30e-06337222691411
Pubmed

Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

APOBEC3D APOBEC3F

3.30e-06337222666481
Pubmed

APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.

APOBEC3D APOBEC3F

3.30e-06337224577894
Pubmed

APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.

APOBEC3D APOBEC3F

3.30e-06337227289067
Pubmed

Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.

APOBEC3D APOBEC3F

3.30e-06337224725948
Pubmed

Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

RYR1 RYR3

3.30e-06337218313230
Pubmed

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.

APOBEC3D APOBEC3F

3.30e-06337216648136
Pubmed

Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.

APOBEC3D APOBEC3F

3.30e-06337223533681
Pubmed

The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.

APOBEC3D APOBEC3F

3.30e-06337220702647
Pubmed

Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.

APOBEC3D APOBEC3F

3.30e-0633721541833
Pubmed

In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.

APOBEC3D APOBEC3F

3.30e-06337227356895
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR3

3.30e-06337222948152
Pubmed

IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.

APOBEC3D APOBEC3F

3.30e-06337223315078
Pubmed

Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.

APOBEC3D APOBEC3F

3.30e-06337220980520
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR3

3.30e-06337210788707
Pubmed

Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.

APOBEC3D APOBEC3F

3.30e-06337225589647
Pubmed

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

APOBEC3D APOBEC3F

3.30e-063372284359
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR3

3.30e-06337218434746
Pubmed

Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.

APOBEC3D APOBEC3F

3.30e-06337220617165
Pubmed

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.

APOBEC3D APOBEC3F

3.30e-06337231801862
Pubmed

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

APOBEC3D APOBEC3F

3.30e-06337239208378
Pubmed

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.

APOBEC3D APOBEC3F

3.30e-06337231943071
Pubmed

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

PLCG1 PLCG2

3.30e-06337229133930
Pubmed

A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.

FZD9 FZD3

3.30e-0633729147651
Pubmed

Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.

PLCG1 PLCG2

3.30e-06337228786489
Pubmed

Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.

APOBEC3D APOBEC3F

3.30e-06337223671100
Pubmed

Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.

APOBEC3D APOBEC3F

3.30e-06337231518043
Cytoband22q13.1

APOBEC3D APOBEC3H APOBEC3F

4.55e-058537322q13.1
CytobandEnsembl 112 genes in cytogenetic band chr22q13

APOBEC3D PKDREJ APOBEC3H APOBEC3F

1.44e-04330374chr22q13
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3D APOBEC3H APOBEC3F

3.42e-0712223406
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR3

4.24e-063222287
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD9 FZD3

7.72e-0511222286
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCG1 PLCG2

2.39e-0419222832
GeneFamilyPhospholipases

PLCG1 PLCG2

1.18e-0342222467
GeneFamilyPHD finger proteins

ING1 NSD2

5.31e-039022288
GeneFamilySH2 domain containing

PLCG1 PLCG2

6.64e-03101222741
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARFGEF3 RYR1

2.02e-02181222694
GeneFamilyEF-hand domain containing

PLCG1 RYR3

2.88e-02219222863
CoexpressionGSE27786_CD8_TCELL_VS_NKTCELL_UP

MRPL38 TMEM130 PLCG1 SFRP2 STK35 RYR3

3.50e-07200376M4839
DrugAC1L1KRB

PLCG1 PLCG2 CABIN1 RYR1 RYR3

2.55e-0854375CID000005621
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

2.57e-062372ctd:C005147
DrugAC1L1CR9

PLCG1 RYR1 RYR3

5.15e-0621373CID000002023
Druglysosphingomyelin

PLCG1 PLCG2 P2RX7 RYR1 RYR3

5.85e-06160375CID000005263
Drug2-hydroxycarbazole

RYR1 RYR3

7.70e-063372CID000093551
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

7.70e-063372CID000080262
Drugcis-diammineplatinum(II

RYR1 RYR3

7.70e-063372CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR3

7.70e-063372CID002750949
Drugflubendiamide

RYR1 RYR3

7.70e-063372CID011193251
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR3

7.70e-063372CID005748312
Drug8N3-cADPR

RYR1 RYR3

7.70e-063372CID000127713
Drugaminodantrolene

RYR1 RYR3

7.70e-063372CID009570289
DrugKn 04

P2RX7 RYR1 RYR3

1.00e-0526373CID000131117
DrugXeC compound

PLCG2 CABIN1 RYR1 RYR3

1.04e-0584374CID000005701
DrugCB1954

NQO2 APOBEC3H APOBEC3F

1.40e-0529373CID000089105
DrugA-30

RYR1 RYR3

1.54e-054372CID003028528
DrugPCB74

RYR1 RYR3

1.54e-054372CID000036218
Drug148504-47-6

RYR1 RYR3

1.54e-054372CID006444275
DrugBastadin 10

RYR1 RYR3

1.54e-054372CID009589366
DrugSC 38249

RYR1 RYR3

1.54e-054372CID000134834
DrugAC1L1U7A

RYR1 RYR3

1.54e-054372CID000035682
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; PC3; HT_HG-U133A

PLCG1 PLCG2 COMMD4 ING1 NSD2

1.68e-051993753668_DN
Drugsevoflurane

PLCG1 PLCG2 RYR1 RYR3

2.51e-05105374CID000005206
DrugMBED

RYR1 RYR3

3.84e-056372CID000129958
Drugchloro-m-cresol

RYR1 RYR3

3.84e-056372CID000012008
DrugSKF83742

PLCG1 PLCG2

3.84e-056372CID000130828
DrugAC1O528X

RYR1 RYR3

3.84e-056372CID006475857
DrugNSC114784

RYR1 RYR3

3.84e-056372CID000419425
DrugNSC692750

RYR1 RYR3

3.84e-056372CID000078910
DrugClorocruoro Hem

PLCG1 PLCG2 RYR1 RYR3

4.67e-05123374CID003518809
DrugAzumoleno

RYR1 RYR3

5.37e-057372CID000056259
Drugmag-indo-1

RYR1 RYR3

5.37e-057372CID000131881
DrugBr2BAPTA

RYR1 RYR3

5.37e-057372CID003081001
Drugkushenol H

PLCG1 PLCG2

5.37e-057372CID005318897
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR3

5.37e-057372CID009547999
DrugCHEBI:564108

RYR1 RYR3

5.37e-057372CID006400637
DrugAC1L1G92

NQO2 RYR1

7.15e-058372CID000003582
Druglactosyl lysosphingolipid

RYR1 RYR3

9.18e-059372CID006439268
DrugFLA 365

RYR1 RYR3

9.18e-059372CID000072776
Druglead compounds

PLCG1 PLCG2 RYR1 RYR3

1.01e-04150374CID000073212
DrugBAPTA-AM

PLCG2 CABIN1 P2RX7 RYR1 RYR3

1.06e-04293375CID000002293
Druglindane

PLCG1 PLCG2 RYR1 RYR3

1.12e-04154374CID000000727
Drugnonyl acridine orange

P2RX7 RYR1

1.15e-0410372CID000115086
DrugAC1N38XE

RYR1 RYR3

1.15e-0410372CID004060965
DrugPCB 95

RYR1 RYR3

1.15e-0410372CID000038012
DrugCHAPS detergent

NQO2 RYR1 RYR3 NOB1

1.23e-04158374CID000107670
DrugHMS3267E16

P2RX7 RYR1 RYR3

1.40e-0462373CID000003668
DrugPCB 66

RYR1 RYR3

1.40e-0411372CID000036185
DrugR 478

RYR1 RYR3

1.40e-0411372CID000084223
Drug8-amino-cADPR

RYR1 RYR3

1.40e-0411372CID003081323
DrugRyanodine

RYR1 RYR3

1.68e-0412372ctd:D012433
DrugBAPTA

PLCG1 CABIN1 P2RX7 RYR1 RYR3

1.70e-04324375CID000104751
DrugLopac-P-178

PLCG1 PLCG2 P2RX7

1.76e-0467373CID005478935
DrugNSC-695672

P2RX7 RYR1 RYR3

1.76e-0467373CID000393593
Drugstrontium

P2RX7 RYR1 RYR3

1.84e-0468373CID000104798
Drugpapaverine

PLCG1 PLCG2 RYR1 RYR3

1.87e-04176374CID000004680
DrugNSC299933

RYR1 RYR3

1.98e-0413372CID000431902
DrugA 172

CABIN1 FZD3 APOBEC3F

2.01e-0470373CID000014025
DrugAC1L1D8L

CABIN1 RYR1 RYR3

2.09e-0471373CID000002241
Drugbimoclomol

RYR1 RYR3

2.31e-0414372CID009576891
DrugNP-EGTA

RYR1 RYR3

2.31e-0414372CID000183793
Drugnickel

PLCG1 PLCG2 CABIN1 RYR1 RYR3 NRP2

2.42e-04552376CID000000934
DrugTriamcinolone [124-94-7]; Down 200; 10.2uM; PC3; HT_HG-U133A

TRAPPC11 PLCG2 FZD3 TBC1D17

2.60e-041923742078_DN
DrugFPL 64176

RYR1 RYR3

2.66e-0415372CID000003423
DrugGvapspat amide

RYR1 RYR3

2.66e-0415372CID000125015
DrugSulfameter [651-06-9]; Down 200; 14.2uM; PC3; HT_HG-U133A

PLCG1 RNF31 CABIN1 CLN5

2.71e-041943745732_DN
DrugCinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

PLCG2 CABIN1 ING1 TBC1D17

2.71e-041943742789_UP
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A

PLCG2 COMMD4 CABIN1 ING1

2.76e-041953745357_DN
Drugmyo-inositol

MRPL38 CEPT1 PLCG1 PLCG2 P2RX7 RYR1 RYR3

2.87e-04811377CID000000892
DrugFK-506; Up 200; 1uM; MCF7; HG-U133A

PLCG1 CABIN1 ING1 FZD3

2.87e-04197374284_UP
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; MCF7; HT_HG-U133A

PLCG2 COMMD4 ING1 TBC1D17

2.87e-041973742265_DN
DrugVinpocetine [42971-09-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A

RNF31 KLHL7 NSD2 CLN5

2.87e-041973747213_DN
DrugLysergol [602-85-7]; Down 200; 15.8uM; MCF7; HT_HG-U133A

PLCG1 COMMD4 CABIN1 TBC1D17

2.93e-041983743261_DN
DrugDexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PLCG2 CABIN1 ING1 KLHL7

2.93e-041983746271_DN
DrugEtanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT_HG-U133A

PLCG1 RNF31 CABIN1 ING1

2.93e-041983746211_DN
Drug5253409; Down 200; 17uM; MCF7; HT_HG-U133A_EA

PLCG1 PLCG2 ING1 CLN5

2.93e-04198374961_DN
DrugDM-nitrophen

RYR1 RYR3

3.04e-0416372CID000003083
Drugkazinol B

RYR1 RYR3

3.44e-0417372CID000480869
Drugreactive blue 2

PLCG1 PLCG2 P2RX7

3.81e-0487373CID000656725
Drugmethylcoumarin

RYR1 RYR3

3.87e-0418372CID000007092
DrugAC1L380G

RYR1 RYR3

4.32e-0419372CID000084698
DrugAC1MW7VF

RYR1 RYR3

4.32e-0419372CID000414699
Drugadenosine diphosphoribose

P2RX7 RYR1 RYR3

4.49e-0492373CID000030243
Drug5-fluoropyrimidine

APOBEC3H APOBEC3F

4.79e-0420372CID000069605
DrugADP beta S

PLCG1 PLCG2 P2RX7

5.09e-0496373CID005310996
Drugdiatrizoate

CABIN1 PKDREJ

5.29e-0421372CID000002140
Drugindo-1/AM

RYR1 RYR3

5.29e-0421372CID000123918
DrugAC1L1GTT

CABIN1 P2RX7 RYR1 RYR3

5.42e-04233374CID000003837
Drugstrontium chromate

P2RX7 RYR1 RYR3

5.57e-0499373CID000024599
Drugvalerate

CABIN1 PKDREJ RYR1

6.07e-04102373CID000007991
DrugPMEI

APOBEC3H APOBEC3F

6.93e-0424372CID000451928
Drug6-methoxypurine arabinoside

PLCG1 PLCG2

6.93e-0424372CID000124757
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR3

3.86e-063342DOID:8545 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR3

3.86e-063342DOID:3529 (implicated_via_orthology)
Diseaseserum gamma-glutamyl transferase measurement

FZD9 CEPT1 PLCG1 CABIN1 P2RX7 ING1

5.56e-04914346EFO_0004532
DiseaseInflammatory Bowel Diseases

SFRP2 PLCG2

7.49e-0435342C0021390
Diseasechronic obstructive pulmonary disease

FZD9 SFRP2 KLHL7 FZD3 NRP2

1.08e-03688345EFO_0000341
DiseaseChronic Lymphocytic Leukemia

PLCG2 P2RX7

1.84e-0355342C0023434
DiseaseAbnormality of chromosome segregation

FZD9 FZD3

2.19e-0360342HP_0002916
Diseasevenous thromboembolism, fibrinogen measurement

SFRP2 PLCG2

2.72e-0367342EFO_0004286, EFO_0004623
DiseaseContact hypersensitivity

NQO2 ING1

3.05e-0371342C0162351
DiseaseContact Dermatitis

NQO2 ING1

3.05e-0371342C0011616
Diseasetestosterone measurement

FZD9 PLCG1 SFRP2 COMMD4 PKDREJ RNF212B

3.06e-031275346EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
MCKEPGWFCLIFADE

ACCSL

521

Q4AC99
MCFLSWFCGNRLPAN

APOBEC3D

81

Q96AK3
MGFPEFADCWENFVD

APOBEC3H

136

Q6NTF7
MDWFHCNQCFRKDGA

RNF212B

1

A8MTL3
ACEPENLEFSSFMFW

NOB1

146

Q9ULX3
DCLNIEMPDGSWFCN

NSD2

856

O96028
EMPDGSWFCNDCRAG

NSD2

861

O96028
SDVCGMNCFWEAAFR

GXYLT1

91

Q4G148
CNFDFLEEPCGWMYD

NRP2

646

O60462
CPFEKRRDAACVFWD

KLHL7

321

Q8IXQ5
MGCRCIELDCWDGPD

PLCG2

351

P16885
WMDRVLCQGFAFDIP

NQO2

116

P16083
QDMADFAILPSCCRW

P2RX7

561

Q99572
MEQFNFGWPDSLDCA

FZD9

126

O00144
AEMCFLSWFCGNQLP

APOBEC3F

66

Q8IUX4
GTNPDWMFFCCFAGT

CEPT1

176

Q9Y6K0
DICICPNRFDSWAGM

CABIN1

1081

Q9Y6J0
GPVFTEEMWRLACCA

ARFGEF3

1596

Q5TH69
MRFRFCGDLDCPDWV

COMMD4

1

Q9H0A8
WPEDMECSRFPDCDE

FZD3

121

Q9NPG1
QERCWDFFPAGDCFR

RYR1

5016

P21817
AFGFPWPDMLECDRF

SFRP2

131

Q96HF1
MPGFFCDCWPSLEIR

FAM78A

1

Q5JUQ0
MNWFGSNFFRCPEDL

PLAC8L1

1

A1L4L8
MIGCDNDECPIEWFH

ING1

366

Q9UK53
MFCDFTNDLFPWLND

PKDREJ

906

Q9NTG1
TWCPADCQFAFMARN

SH2D5

96

Q6ZV89
PEMDAPFWCNQGAAC

CLN5

151

O75503
MRDPKFLWCAQCSFG

RNF31

791

Q96EP0
DAFWCFCGFMELVQG

TBC1D17

436

Q9HA65
EEPCYLWFVMEFCEG

STK35

306

Q8TDR2
WDFPVELCCRPMAFV

TRAPPC11

6

Q7Z392
MTPAGLSFFQCRWDD

MRPL38

311

Q96DV4
MYQERCWDFFPAGDC

RYR3

4846

Q15413
MAGFLDNFRWPECEC

TMEM50B

1

P56557
CRCIELDCWDGPDGM

PLCG1

361

P19174
AADCWMCQPVARGFV

TMEM130

111

Q8N3G9
FVMFFAPWCGHCQRL

TXNDC5

81

Q8NBS9