Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF479 ZBTB49 ZNF431 ZBTB26 ZBTB6 ZNF723 ZNF366 ZNF682 ZFX ZFY ZNF197	2.71e-07	1244	27	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF479 ZBTB49 ZNF431 ZBTB26 ZBTB6 ZNF723 ZNF366 ZNF682 ZFX ZFY ZNF197	3.36e-07	1271	27	11	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF479 ZBTB49 ZNF431 ZBTB26 ZBTB6 ZNF723 ZNF366 ZNF682 ZFX ZFY ZNF197	1.33e-06	1459	27	11	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF479 ZBTB49 ZNF431 ZBTB26 ZBTB6 ZNF723 ZNF682 ZFX ZFY ZNF197	8.38e-06	1412	27	10	GO:0000981
GeneOntologyMolecularFunction	chromatin insulator sequence binding	ZFX ZFY	3.68e-05	7	27	2	GO:0043035
GeneOntologyMolecularFunction	p53 binding	BRCA1 MDM2 BRD4	1.51e-04	77	27	3	GO:0002039
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZBTB49 ZBTB26 ZBTB6 ZNF682	8.49e-04	320	27	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	BRCA1 ZNF682 ZFX ZFY ZNF197	8.65e-04	566	27	5	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZBTB49 ZBTB26 ZBTB6 ZNF682	9.10e-04	326	27	4	GO:0001217
GeneOntologyMolecularFunction	chromatin binding	ZNF431 BRCA1 BRD4 ZFX ZFY	2.81e-03	739	27	5	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase binding	BRCA1 BRD4	3.47e-03	65	27	2	GO:0070063
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF682 ZFX ZFY ZNF197	6.43e-03	560	27	4	GO:0001228
GeneOntologyBiologicalProcess	oogenesis	TAF4B ZFX ZFY PRAMEF20	4.82e-05	156	27	4	GO:0048477
GeneOntologyBiologicalProcess	negative regulation of intracellular estrogen receptor signaling pathway	BRCA1 ZNF366	1.71e-04	15	27	2	GO:0033147
GeneOntologyBiologicalProcess	cell cycle checkpoint signaling	BRCA1 MDM2 BRD4 ZFY	1.73e-04	217	27	4	GO:0000075
GeneOntologyBiologicalProcess	female gamete generation	TAF4B ZFX ZFY PRAMEF20	1.92e-04	223	27	4	GO:0007292
GeneOntologyBiologicalProcess	oocyte development	ZFX ZFY PRAMEF20	2.89e-04	99	27	3	GO:0048599
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ZBTB49 ZNF407 TAF4B BRCA1 BRD4 ZFX ZFY ZNF197	2.91e-04	1390	27	8	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZBTB49 ZNF431 ZBTB26 ZBTB6 BRCA1 MDM2 ZNF366 PRAMEF20	3.04e-04	1399	27	8	GO:0045892
GeneOntologyBiologicalProcess	oocyte differentiation	ZFX ZFY PRAMEF20	3.24e-04	103	27	3	GO:0009994
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZBTB49 ZNF431 ZBTB26 ZBTB6 BRCA1 MDM2 ZNF366 PRAMEF20	3.25e-04	1413	27	8	GO:1902679
GeneOntologyBiologicalProcess	parental behavior	ZFX ZFY	3.41e-04	21	27	2	GO:0060746
GeneOntologyBiologicalProcess	dosage compensation by inactivation of X chromosome	BRCA1 ZFY	3.75e-04	22	27	2	GO:0009048
GeneOntologyBiologicalProcess	sex-chromosome dosage compensation	BRCA1 ZFY	4.47e-04	24	27	2	GO:0007549
GeneOntologyBiologicalProcess	regulation of DNA damage checkpoint	BRCA1 BRD4	4.47e-04	24	27	2	GO:2000001
GeneOntologyBiologicalProcess	negative regulation of cell cycle phase transition	BRCA1 MDM2 BRD4 ZFY	6.77e-04	311	27	4	GO:1901988
GeneOntologyBiologicalProcess	DNA damage checkpoint signaling	BRCA1 MDM2 BRD4	7.30e-04	136	27	3	GO:0000077
GeneOntologyBiologicalProcess	DNA integrity checkpoint signaling	BRCA1 MDM2 BRD4	8.80e-04	145	27	3	GO:0031570
GeneOntologyBiologicalProcess	regulation of intracellular estrogen receptor signaling pathway	BRCA1 ZNF366	1.01e-03	36	27	2	GO:0033146
GeneOntologyBiologicalProcess	negative regulation of cell cycle process	BRCA1 MDM2 BRD4 ZFY	1.19e-03	362	27	4	GO:0010948
GeneOntologyBiologicalProcess	negative regulation of intracellular steroid hormone receptor signaling pathway	BRCA1 ZNF366	1.25e-03	40	27	2	GO:0033144
Domain	-	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	6.35e-10	679	26	11	3.30.160.60
Domain	zf-C2H2	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	7.88e-10	693	26	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	8.00e-10	694	26	11	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	2.56e-09	775	26	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	2.63e-09	777	26	11	PS00028
Domain	Znf_C2H2-like	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	3.38e-09	796	26	11	IPR015880
Domain	Znf_C2H2	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	3.80e-09	805	26	11	IPR007087
Domain	ZnF_C2H2	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	3.95e-09	808	26	11	SM00355
Domain	zf-C2H2_6	ZNF479 ZBTB49 ZNF431 ZNF366 ZNF682 ZNF197	3.73e-06	314	26	6	PF13912
Domain	Zfx_Zfy_act	ZFX ZFY	5.59e-06	3	26	2	PF04704
Domain	Transcrp_activ_Zfx/Zfy-dom	ZFX ZFY	5.59e-06	3	26	2	IPR006794
Domain	KRAB	ZNF479 ZNF431 ZNF738 ZNF682 ZNF197	1.19e-04	358	26	5	PS50805
Domain	KRAB	ZNF479 ZNF431 ZNF738 ZNF682 ZNF197	1.19e-04	358	26	5	PF01352
Domain	KRAB	ZNF479 ZNF431 ZNF738 ZNF682 ZNF197	1.37e-04	369	26	5	SM00349
Domain	KRAB	ZNF479 ZNF431 ZNF738 ZNF682 ZNF197	1.39e-04	370	26	5	IPR001909
Domain	BTB	ZBTB49 ZBTB26 ZBTB6	7.79e-04	131	26	3	PF00651
Domain	BTB	ZBTB49 ZBTB26 ZBTB6	1.39e-03	160	26	3	PS50097
Domain	BTB	ZBTB49 ZBTB26 ZBTB6	1.94e-03	180	26	3	SM00225
Domain	BTB/POZ_dom	ZBTB49 ZBTB26 ZBTB6	2.10e-03	185	26	3	IPR000210
Domain	SKP1/BTB/POZ	ZBTB49 ZBTB26 ZBTB6	2.23e-03	189	26	3	IPR011333
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF479 ZNF431 TAF4B BRCA1 MDM2 ZNF738 ZNF682 ZNF197 CYCS	3.12e-05	1387	19	9	M734
Pathway	WP_DNA_DAMAGE_RESPONSE	BRCA1 MDM2 CYCS	1.03e-04	69	19	3	M39339
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	TAF4B BRCA1 MDM2	2.42e-04	92	19	3	M27636
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	TAF4B BRCA1 MDM2	2.42e-04	92	19	3	MM15338
Pathway	BIOCARTA_ATM_PATHWAY	BRCA1 MDM2	2.90e-04	19	19	2	MM1351
Pathway	WP_MIRNA_REGULATION_OF_DNA_DAMAGE_RESPONSE	BRCA1 MDM2 CYCS	2.91e-04	98	19	3	M39524
Pathway	BIOCARTA_ATM_PATHWAY	BRCA1 MDM2	3.22e-04	20	19	2	M10628
Pathway	BIOCARTA_G2_PATHWAY	BRCA1 MDM2	3.91e-04	22	19	2	MM1365
Pathway	BIOCARTA_G2_PATHWAY	BRCA1 MDM2	4.67e-04	24	19	2	M8560
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	BRCA1 MDM2 ZFX ZFY	6.13e-04	301	19	4	MM15983
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	TAF4B BRCA1 MDM2 CYCS	6.36e-04	304	19	4	MM14960
Pathway	PID_AURORA_A_PATHWAY	BRCA1 MDM2	7.82e-04	31	19	2	M242
Pathway	PID_ATM_PATHWAY	BRCA1 MDM2	9.41e-04	34	19	2	M84
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	TAF4B BRCA1 MDM2	1.15e-03	157	19	3	MM15226
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	TAF4B BRCA1 MDM2 CYCS	1.20e-03	360	19	4	M27267
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	TAF4B BRCA1 MDM2	1.22e-03	160	19	3	M27498
Pathway	WP_ATM_SIGNALING	BRCA1 MDM2	1.30e-03	40	19	2	M39433
Pathway	PID_CERAMIDE_PATHWAY	KSR1 CYCS	1.57e-03	44	19	2	M144
Pathway	WP_INTEGRATED_CANCER_PATHWAY	BRCA1 MDM2	1.87e-03	48	19	2	M39628
Pathway	WP_VEGFAVEGFR2_SIGNALING	MDM2 BRD4 CSRP1 CYCS	2.32e-03	431	19	4	M39729
Pathway	WP_DNA_IRDOUBLE_STRAND_BREAKS_AND_CELLULAR_RESPONSE_VIA_ATM	BRCA1 MDM2	2.45e-03	55	19	2	M39598
Pathway	BIOCARTA_HIVNEF_PATHWAY	MDM2 CYCS	2.54e-03	56	19	2	MM1406
Pubmed	Isolation of monochromosomal hybrids for mouse chromosomes 3, 6, 10, 12, 14, and 18.	ST6GAL1 ZFX ZFY	4.17e-10	3	27	3	9060403
Pubmed	Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.	BRCA1 MDM2	5.80e-07	2	27	2	23039163
Pubmed	Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.	ZFX ZFY	5.80e-07	2	27	2	1691708
Pubmed	The structure of the Zfx gene on the mouse X chromosome.	ZFX ZFY	5.80e-07	2	27	2	8188262
Pubmed	Mapping the human ZFX locus to Xp21.3 by in situ hybridization.	ZFX ZFY	5.80e-07	2	27	2	2497060
Pubmed	Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.	BRCA1 MDM2	5.80e-07	2	27	2	16563154
Pubmed	Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.	ZFX ZFY	5.80e-07	2	27	2	2041734
Pubmed	Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice.	ZFX ZFY	5.80e-07	2	27	2	8318216
Pubmed	Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.	ZFX ZFY	5.80e-07	2	27	2	2105457
Pubmed	[Expression of Zfx in mouse testicular spermatogenic cells].	ZFX ZFY	5.80e-07	2	27	2	38602753
Pubmed	Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.	ZFX ZFY	5.80e-07	2	27	2	12716983
Pubmed	Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.	ZFX ZFY	5.80e-07	2	27	2	9126493
Pubmed	Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.	ZFX ZFY	5.80e-07	2	27	2	19329779
Pubmed	Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.	ZFX ZFY	5.80e-07	2	27	2	1970799
Pubmed	Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.	ZFX ZFY	5.80e-07	2	27	2	8487630
Pubmed	Comparison of human ZFY and ZFX transcripts.	ZFX ZFY	5.80e-07	2	27	2	2308929
Pubmed	RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.	ZFX ZFY	5.80e-07	2	27	2	28251288
Pubmed	Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.	ZFX ZFY	5.80e-07	2	27	2	34324278
Pubmed	Zfx mutation results in small animal size and reduced germ cell number in male and female mice.	ZFX ZFY	5.80e-07	2	27	2	9187153
Pubmed	Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.	ZFX ZFY	5.80e-07	2	27	2	2265557
Pubmed	MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.	BRCA1 MDM2	1.74e-06	3	27	2	18026875
Pubmed	Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.	ZFX ZFY	1.74e-06	3	27	2	2480529
Pubmed	Genetic dissection of mammalian fertility pathways.	ZFX ZFY	1.74e-06	3	27	2	12479614
Pubmed	X chromosome genes and premature ovarian failure.	ZFX ZFY	1.74e-06	3	27	2	11299520
Pubmed	Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.	ZFX ZFY	1.74e-06	3	27	2	32406922
Pubmed	BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy.	BRCA1 BRD4	1.74e-06	3	27	2	30259975
Pubmed	BRCA1 physically associates with p53 and stimulates its transcriptional activity.	BRCA1 MDM2	1.74e-06	3	27	2	9582019
Pubmed	Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations.	BRCA1 MDM2	1.74e-06	3	27	2	19226467
Pubmed	Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.	ZFX ZFY	1.74e-06	3	27	2	38310188
Pubmed	YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.	ZFX ZFY	1.74e-06	3	27	2	8406471
Pubmed	BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis.	MDM2 BRD4	1.74e-06	3	27	2	38773379
Pubmed	ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.	ZFX ZFY	3.48e-06	4	27	2	24485662
Pubmed	The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	BRCA1 MDM2	3.48e-06	4	27	2	19707196
Pubmed	Zfx controls the self-renewal of embryonic and hematopoietic stem cells.	ZFX ZFY	3.48e-06	4	27	2	17448993
Pubmed	The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr).	ZFX ZFY	5.80e-06	5	27	2	9244432
Pubmed	Chromosome mapping and expression of a putative testis-determining gene in mouse.	ZFX ZFY	5.80e-06	5	27	2	2563174
Pubmed	MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.	ZFX ZFY	5.80e-06	5	27	2	9721210
Pubmed	Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.	ZFX ZFY	5.80e-06	5	27	2	25164012
Pubmed	Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system.	ZFX ZFY	5.80e-06	5	27	2	7681608
Pubmed	Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily.	ZFX ZFY	8.69e-06	6	27	2	7821804
Pubmed	Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.	BRCA1 MDM2	8.69e-06	6	27	2	28005077
Pubmed	An evaluation of the inactive mouse X chromosome in somatic cell hybrids.	ZFX ZFY	1.22e-05	7	27	2	8460399
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	ZFX ZFY	1.22e-05	7	27	2	9196009
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	ZFX ZFY	1.22e-05	7	27	2	8378320
Pubmed	Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of selfish Y-linked growth factors may explain escape from X-inactivation and rapid evolution of Sry.	ZFX ZFY	1.22e-05	7	27	2	7928394
Pubmed	The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.	ZFX ZFY	1.22e-05	7	27	2	9588208
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZBTB49 ZBTB6 BRCA1 BRD4 ZFX ZFY	1.44e-05	709	27	6	22988430
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB49 ZBTB26 ZBTB6	1.61e-05	63	27	3	34351428
Pubmed	Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.	ZFX ZFY	1.62e-05	8	27	2	2034279
Pubmed	Genetic mapping in the region of the mouse X-inactivation center.	ZFX ZFY	1.62e-05	8	27	2	1974879
Pubmed	High-density molecular map of the central span of the mouse X chromosome.	ZFX ZFY	1.62e-05	8	27	2	1675191
Pubmed	Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.	BRCA1 ZFX ZFY	1.93e-05	67	27	3	10441734
Pubmed	The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.	BRCA1 MDM2	2.08e-05	9	27	2	8674108
Pubmed	Praja1, a novel gene encoding a RING-H2 motif in mouse development.	ZFX ZFY	2.08e-05	9	27	2	9393880
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	ZFX ZFY	2.08e-05	9	27	2	11956759
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	ZFX ZFY	2.08e-05	9	27	2	7590750
Pubmed	Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.	ZFX ZFY	2.08e-05	9	27	2	7874112
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	ZFX ZFY	2.08e-05	9	27	2	9300697
Pubmed	Brca2 is required for embryonic cellular proliferation in the mouse.	BRCA1 MDM2	2.08e-05	9	27	2	9171369
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	ZFX ZFY	2.60e-05	10	27	2	2055107
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	ZFX ZFY	2.60e-05	10	27	2	1973380
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	ZFX ZFY	3.18e-05	11	27	2	2034278
Pubmed	The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.	ZFX ZFY	3.81e-05	12	27	2	1916827
Pubmed	Zinc finger protein genes in the mouse genome.	ZFX ZFY	3.81e-05	12	27	2	1797234
Pubmed	Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region.	ZFX ZFY	4.50e-05	13	27	2	2721933
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	ZFX ZFY	4.50e-05	13	27	2	1740345
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	ZFX ZFY	4.50e-05	13	27	2	1772416
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	ZFX ZFY	4.50e-05	13	27	2	7805729
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	ZFX ZFY	5.25e-05	14	27	2	8432533
Pubmed	Molecular phylogenetics and the origins of placental mammals.	ZFX ZFY	6.06e-05	15	27	2	11214319
Pubmed	E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.	BRCA1 MDM2	6.06e-05	15	27	2	21965653
Pubmed	Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.	ZFX ZFY	6.06e-05	15	27	2	11353388
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	ZFX ZFY	6.06e-05	15	27	2	14762062
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	ZNF407 ALPK2	7.84e-05	17	27	2	19690890
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	ZFX ZFY	7.84e-05	17	27	2	19571810
Pubmed	Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.	TAF4B MDM2	8.81e-05	18	27	2	15053879
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	BRCA1 MDM2	9.84e-05	19	27	2	14578343
Pubmed	Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells.	MDM2 CSRP1	9.84e-05	19	27	2	35073964
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	ZFX ZFY	1.86e-04	26	27	2	10920247
Pubmed	Gene knockouts that cause female infertility: search for novel contraceptive targets.	ZFX ZFY	2.17e-04	28	27	2	15970507
Pubmed	The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.	BRCA1 MDM2	2.33e-04	29	27	2	19094228
Pubmed	Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.	BRCA1 MDM2	2.66e-04	31	27	2	20813000
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	BRCA1 MDM2	3.80e-04	37	27	2	19116388
Pubmed	Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.	ZFX ZFY	3.80e-04	37	27	2	19865483
Interaction	ZFX interactions	BRD4 ZFX ZFY	3.35e-06	24	25	3	int:ZFX
Interaction	ZBTB9 interactions	HAUS7 ZNF407 ZBTB26 ZFY	1.24e-05	117	25	4	int:ZBTB9
Interaction	SUMO1 interactions	ZBTB26 ZBTB6 BRCA1 MDM2 BRD4	2.38e-05	287	25	5	int:SUMO1
Interaction	CWC25 interactions	KSR1 MDM2 CYCS	4.97e-05	58	25	3	int:CWC25
Cytoband	19p12	ZNF431 ZNF723 ZNF738 ZNF682	2.34e-07	90	27	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF431 ZNF723 ZNF738 ZNF682	7.94e-07	122	27	4	chr19p12
Cytoband	9q33.2	ZBTB26 ZBTB6	2.44e-04	39	27	2	9q33.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	ZBTB26 ZBTB6	3.00e-03	138	27	2	chr9q33
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF479 ZBTB49 ZNF407 ZNF431 ZBTB26 ZBTB6 ZNF366 ZNF682 ZFX ZFY ZNF197	8.81e-11	718	21	11	28
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB49 ZBTB26 ZBTB6	4.80e-04	134	21	3	861
Computational	Neighborhood of PAX7	PDE6A BRCA1 MDM2 BRD4	3.02e-04	266	14	4	MORF_PAX7
Computational	Neighborhood of MDM2	PDE6A BRCA1 MDM2 BRD4	3.62e-04	279	14	4	MORF_MDM2
Computational	Neighborhood of NOS2A	PDE6A BRCA1 MDM2 BRD4	4.09e-04	288	14	4	MORF_NOS2A
Computational	Neighborhood of CAMK4	PDE6A BRCA1 MDM2 BRD4	4.19e-04	290	14	4	MORF_CAMK4
Computational	Neighborhood of MLLT10	PDE6A BRCA1 MDM2 BRD4	4.89e-04	302	14	4	MORF_MLLT10
Computational	Neighborhood of ARL3	PDE6A BRCA1 MDM2 BRD4	5.02e-04	304	14	4	MORF_ARL3
Computational	Neighborhood of ERCC4	PDE6A BRCA1 MDM2 BRD4	6.16e-04	321	14	4	MORF_ERCC4
Computational	Neighborhood of SUPT3H	PDE6A BRCA1 MDM2 BRD4	6.69e-04	328	14	4	MORF_SUPT3H
Computational	Neighborhood of ATF2	PDE6A BRCA1 MDM2 BRD4	6.84e-04	330	14	4	MORF_ATF2
Computational	Neighborhood of TNFRSF6	PDE6A MDM2 BRD4	1.18e-03	167	14	3	MORF_TNFRSF6
Computational	Neighborhood of RAD51L3	PDE6A BRCA1 MDM2 BRD4	1.24e-03	387	14	4	MORF_RAD51L3
Computational	Neighborhood of PPP2R5B	PDE6A BRCA1 MDM2	1.31e-03	173	14	3	MORF_PPP2R5B
Computational	Neighborhood of FOSL1	PDE6A BRCA1 MDM2 BRD4	1.48e-03	406	14	4	MORF_FOSL1
Computational	Neighborhood of MAP2K7	PDE6A MDM2 BRD4	1.49e-03	181	14	3	MORF_MAP2K7
Computational	Neighborhood of BCL2L11	PDE6A BRCA1 MDM2	1.61e-03	186	14	3	MORF_BCL2L11
Computational	Neighborhood of CTSB	PDE6A MDM2 BRD4	1.64e-03	187	14	3	MORF_CTSB
Computational	Neighborhood of MAGEA9	PDE6A BRCA1 MDM2 BRD4	1.73e-03	423	14	4	MORF_MAGEA9
Computational	Neighborhood of IL4	PDE6A MDM2 BRD4	1.77e-03	192	14	3	MORF_IL4
Computational	Neighborhood of IFNA1	PDE6A MDM2 BRD4	2.13e-03	205	14	3	MORF_IFNA1
Computational	Neighborhood of IL16	PDE6A BRCA1 MDM2	3.30e-03	239	14	3	MORF_IL16
Computational	Neighborhood of MSH3	PDE6A BRCA1 MDM2	3.45e-03	243	14	3	MORF_MSH3
Computational	Neighborhood of MAGEA8	PDE6A MDM2 BRD4	4.18e-03	260	14	3	MORF_MAGEA8
Computational	Neighborhood of BRCA1	PDE6A BRCA1 MDM2	4.32e-03	263	14	3	MORF_BRCA1
Computational	Neighborhood of FSHR	PDE6A MDM2 BRD4	5.09e-03	279	14	3	MORF_FSHR
Computational	Neighborhood of PTPRR	MDM2 BRD4	7.53e-03	102	14	2	MORF_PTPRR
Computational	Thymus genes.	ST6GAL1 CLEC3B BRD4	7.78e-03	325	14	3	MODULE_44
Drug	(2S)-4-[[(2S)-1,4-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]amino]-2-[[(3S)-3,4-bis(oxidanyl)-4-oxidanylidene-butyl]amino]butanoic acid	CLEC3B ZFX ZFY CYCS	1.16e-06	70	26	4	CID009996931
Disease	breast adenocarcinoma (is_implicated_in)	KSR1 BRCA1	3.80e-06	4	24	2	DOID:3458 (is_implicated_in)
Disease	colon cancer (is_implicated_in)	BRCA1 BRD4	3.93e-04	36	24	2	DOID:219 (is_implicated_in)
Disease	Prostatic Neoplasms	BRCA1 MDM2 BRD4 CSRP1	1.43e-03	616	24	4	C0033578
Disease	Malignant neoplasm of prostate	BRCA1 MDM2 BRD4 CSRP1	1.43e-03	616	24	4	C0376358
Disease	pancreatic cancer (is_implicated_in)	BRCA1 CYCS	3.73e-03	112	24	2	DOID:1793 (is_implicated_in)
Disease	Malignant Neoplasms	BRCA1 MDM2	4.84e-03	128	24	2	C0006826
Disease	severe acute respiratory syndrome, COVID-19	HAUS7 KSR1 ST6GAL1	5.52e-03	447	24	3	EFO_0000694, MONDO_0100096
Disease	lung non-small cell carcinoma (is_implicated_in)	BRCA1 CYCS	5.68e-03	139	24	2	DOID:3908 (is_implicated_in)
Disease	Neoplastic Cell Transformation	BRCA1 MDM2	5.68e-03	139	24	2	C0007621

Protein segments in the cluster

Peptide	Gene	Start	Entry
CCSGILKEMFAKKHA	BRD4	356	O60885
KALHQCNKYCKMLGL	ALPK2	2116	Q86TB3
HKSCFLCMVCKKNLD	CSRP1	31	P21291
HVCQKSMIFGVKCKH	KSR1	361	Q8IVT5
KCIFNVMKKLCFLLQ	PDE6A	76	P16499
HIFCKFCMLKLLNQK	BRCA1	41	P38398
KGKKIFIMKCSQCHT	CYCS	6	P99999
LLKGCACAQKQLHFM	HAUS7	116	Q99871
LCHMKNMFKTCRLAK	RUBCN	816	Q92622
KCKNFLAMLIKLACS	TAF4B	261	Q92750
GHLMACFTCAKKLKK	MDM2	456	Q00987
CCKKLKMLGMLFHNI	PRAMEF20	181	Q5VT98
MIHTNLKKKFSCCVL	ST6GAL1	1	P15907
CKKCGKSFCMLLHLS	ZNF431	206	Q8TF32
CKKCGKSFCMLLHLG	ZNF738	206	Q8NE65
KCDMCCKHFNKISHL	ZNF197	371	O14709
CLKGTKVHMKCFLAF	CLEC3B	71	P05452
KECGKSFCMLSHLTK	ZNF723	176	P0DPD5
RHTTEKLFKCMQCGK	ZNF682	166	O95780
KLFKCMQCGKVFKSH	ZNF682	171	O95780
KCNKYGKSFCMLSHL	ZNF479	186	Q96JC4
KCKLCGKEFNRMHNL	ZNF366	506	Q8N895
GKKMHQCRHCDFKIA	ZFX	686	P17010
DCMLVVKGVCFKAHK	ZBTB49	26	Q6ZSB9
KCHVCGVAFVMKKHL	ZNF407	1596	Q9C0G0
HLKMHKLFMCLLCGK	ZBTB26	291	Q9HCK0
KLFMCLLCGKTFTQK	ZBTB26	296	Q9HCK0
KGKKMHQCRHCDFKI	ZFY	681	P08048
KMHKLFLCLQCGKTF	ZBTB6	321	Q15916