Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 3-kinase activity

PIK3C2A PIK3C2B PIK3CG

5.79e-077523GO:0035005
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3C2A PIK3C2B PIK3CG

2.71e-0611523GO:0016303
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3C2A PIK3C2B PIK3CG

4.15e-0526523GO:0052742
GeneOntologyMolecularFunction1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

PIK3C2A PIK3CG

1.39e-047522GO:0046934
GeneOntologyMolecularFunctionlipid kinase activity

PIK3C2A PIK3C2B PIK3CG

1.66e-0441523GO:0001727
GeneOntologyBiologicalProcessmuscle contraction

PIK3C2A DSP MTOR SGCD PIK3CG ACTN2 IRAG1 ATP2B1

5.73e-06400518GO:0006936
GeneOntologyBiologicalProcessphosphatidylinositol-3-phosphate biosynthetic process

PIK3C2A PIK3C2B PIK3CG

2.12e-0522513GO:0036092
GeneOntologyBiologicalProcessphosphatidylinositol-mediated signaling

PIK3C2A PIK3C2B PIK3CG

2.78e-0524513GO:0048015
GeneOntologyBiologicalProcessmuscle system process

PIK3C2A DSP MTOR SGCD PIK3CG ACTN2 IRAG1 ATP2B1

5.42e-05547518GO:0003012
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

LHCGR PIRT PIK3C2A MTOR PIK3CG ACTN2 ATP2B1 CNTN1

7.88e-05577518GO:0043269
GeneOntologyBiologicalProcessheart contraction

SGCZ DSP MTOR SGCD PIK3CG ATP2B1

9.02e-05298516GO:0060047
GeneOntologyBiologicalProcessheart process

SGCZ DSP MTOR SGCD PIK3CG ATP2B1

1.10e-04309516GO:0003015
GeneOntologyBiologicalProcesscardiac muscle tissue development

SGCZ DSP MTOR SGCD ACTN2 CCNB1

1.50e-04327516GO:0048738
GeneOntologyBiologicalProcessblood circulation

SGCZ PIK3C2A DSP MTOR SGCD PIK3CG IRAG1 ATP2B1

1.75e-04648518GO:0008015
GeneOntologyBiologicalProcessstriated muscle tissue development

SGCZ DSP MTOR SGCD ACTN2 CCNB1

2.13e-04349516GO:0014706
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

PIK3C2A PIK3C2B PIK3CG

5.07e-0529523GO:0005942
GeneOntologyCellularComponentsarcoglycan complex

SGCZ SGCD

9.05e-056522GO:0016012
GeneOntologyCellularComponentdystroglycan complex

SGCZ SGCD

1.26e-047522GO:0016011
GeneOntologyCellularComponentfascia adherens

DSP CDH2

4.65e-0413522GO:0005916
GeneOntologyCellularComponentearly phagosome

UNC13B TLR7

5.42e-0414522GO:0032009
GeneOntologyCellularComponentcytoplasmic ubiquitin ligase complex

CUL2 MARCHF6

5.42e-0414522GO:0000153
GeneOntologyCellularComponentpresynaptic membrane

UNC13B SLC6A5 CDH2 ATP2B1 CNTN1

6.16e-04277525GO:0042734
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

SGCZ SGCD

1.12e-0320522GO:0016010
GeneOntologyCellularComponenttransferase complex, transferring phosphorus-containing groups

ERCC3 PIK3C2A PIK3C2B PIK3CG CCNB1

1.44e-03335525GO:0061695
GeneOntologyCellularComponentglycoprotein complex

SGCZ SGCD

1.76e-0325522GO:0090665
DomainPI3/4_kinase_CS

PIK3C2A PIK3C2B MTOR PIK3CG

6.07e-0815504IPR018936
Domain-

PIK3C2A PIK3C2B MTOR PIK3CG

8.08e-08165041.10.1070.11
DomainPI3Kc

PIK3C2A PIK3C2B MTOR PIK3CG

8.08e-0816504SM00146
DomainPI3/4_kinase_cat_dom

PIK3C2A PIK3C2B MTOR PIK3CG

1.35e-0718504IPR000403
DomainPI3_PI4_kinase

PIK3C2A PIK3C2B MTOR PIK3CG

1.35e-0718504PF00454
DomainPI3_4_KINASE_3

PIK3C2A PIK3C2B MTOR PIK3CG

1.35e-0718504PS50290
DomainPI3_4_KINASE_1

PIK3C2A PIK3C2B MTOR PIK3CG

1.35e-0718504PS00915
DomainPI3_4_KINASE_2

PIK3C2A PIK3C2B MTOR PIK3CG

1.35e-0718504PS00916
DomainPI3K_Ras-bd_dom

PIK3C2A PIK3C2B PIK3CG

6.27e-077503IPR000341
DomainPI3K_rbd

PIK3C2A PIK3C2B PIK3CG

6.27e-077503PF00794
DomainPI3K_RBD

PIK3C2A PIK3C2B PIK3CG

6.27e-077503PS51546
DomainPI3K_rbd

PIK3C2A PIK3C2B PIK3CG

6.27e-077503SM00144
DomainPI3K_C2_dom

PIK3C2A PIK3C2B PIK3CG

1.00e-068503IPR002420
DomainPI3K_C2

PIK3C2A PIK3C2B PIK3CG

1.00e-068503PF00792
DomainPI3K_C2

PIK3C2A PIK3C2B PIK3CG

1.00e-068503PS51547
DomainPI3K_C2

PIK3C2A PIK3C2B PIK3CG

1.00e-068503SM00142
DomainPI3Ka

PIK3C2A PIK3C2B PIK3CG

1.50e-069503PF00613
Domain-

PIK3C2A PIK3C2B PIK3CG

1.50e-0695031.25.40.70
DomainPI3Ka

PIK3C2A PIK3C2B PIK3CG

1.50e-069503SM00145
DomainPIK_HELICAL

PIK3C2A PIK3C2B PIK3CG

2.14e-0610503PS51545
DomainPI_Kinase

PIK3C2A PIK3C2B PIK3CG

2.14e-0610503IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C2A PIK3C2B PIK3CG

2.14e-0610503IPR001263
DomainSarcoglycan_1

SGCZ SGCD

4.20e-054502PF04790
DomainSarcoglycan

SGCZ SGCD

4.20e-054502IPR006875
DomainLRR_5

LHCGR TLR7

3.12e-0410502PF13306
DomainLRR_5

LHCGR TLR7

3.12e-0410502IPR026906
Domain-

UNC13B PIK3C2A PIK3C2B PIK3CG

6.57e-041485042.60.40.150
DomainC2_dom

UNC13B PIK3C2A PIK3C2B PIK3CG

9.64e-04164504IPR000008
DomainTIR

TLR7 IL1RL1

1.43e-0321502SM00255
DomainTIR

TLR7 IL1RL1

1.57e-0322502PF01582
Domain-

TLR7 IL1RL1

1.71e-03235023.40.50.10140
DomainTIR

TLR7 IL1RL1

1.87e-0324502PS50104
DomainTIR_dom

TLR7 IL1RL1

2.03e-0325502IPR000157
DomainARM-type_fold

PIK3C2A PIK3C2B MTOR PIK3CG SYMPK

2.08e-03339505IPR016024
DomainSpectrin_repeat

DSP ACTN2

2.72e-0329502IPR002017
DomainSpectrin/alpha-actinin

DSP ACTN2

3.31e-0332502IPR018159
DomainSPEC

DSP ACTN2

3.31e-0332502SM00150
DomainC2

UNC13B PIK3C2A PIK3C2B

5.20e-03131503PF00168
DomainC2

UNC13B PIK3C2A PIK3C2B

5.88e-03137503SM00239
DomainPX

PIK3C2A PIK3C2B

6.18e-0344502SM00312
DomainC2

UNC13B PIK3C2A PIK3C2B

6.50e-03142503PS50004
DomainPX

PIK3C2A PIK3C2B

7.62e-0349502PF00787
DomainPX

PIK3C2A PIK3C2B

7.93e-0350502PS50195
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

DSP SGCD ACTN2 CDH2

4.51e-0574384M16376
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

DSP SGCD ACTN2 CDH2

4.51e-0574384M39462
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PIK3C2A PIK3C2B PIK3CG

2.53e-0446383M48317
PathwayWP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS

PIK3C2A PIK3C2B MTOR PIK3CG

2.85e-04119384M48309
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PIK3C2A PIK3C2B PIK3CG

3.06e-0449383M40046
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

PIK3C2A PIK3C2B PIK3CG

3.25e-0450383MM14641
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

PIK3C2A PIK3C2B PIK3CG

3.86e-0453383M662
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PIK3C2A PIK3C2B PIK3CG

4.08e-0454383M3896
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

PIK3C2A MAP4K3 MTOR PIK3CG

4.24e-04132384M39338
PathwayWP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION

MTOR PIK3CG

4.59e-0412382M45559
Pubmed

Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.

PIK3C2A PIK3C2B PIK3CG

3.15e-09352323320105
Pubmed

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

PIK3C2A PIK3C2B PIK3CG

3.75e-07105238636073
Pubmed

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

PIK3C2A PIK3C2B PIK3CG

3.75e-07105238798481
Pubmed

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.

PIK3C2A PIK3C2B PIK3CG

3.75e-07105239247029
Pubmed

HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

PIK3C2A PIK3C2B PIK3CG

5.16e-071152316081599
Pubmed

HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.

PIK3C2A PIK3C2B PIK3CG

5.16e-07115239708406
Pubmed

HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.

PIK3C2A PIK3C2B PIK3CG

5.16e-071152310985305
Pubmed

Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.

PIK3C2A PIK3C2B PIK3CG

5.16e-071152312584329
Pubmed

Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.

PIK3C2A PIK3C2B PIK3CG

5.16e-07115239808187
Pubmed

Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.

PIK3C2A PIK3C2B PIK3CG

6.87e-071252314602571
Pubmed

Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.

PIK3C2A PIK3C2B PIK3CG

6.87e-071252316514418
Pubmed

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

PIK3C2A PIK3C2B PIK3CG

6.87e-071252310208934
Pubmed

Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.

PIK3C2A PIK3C2B PIK3CG

6.87e-071252312077252
Pubmed

Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.

PIK3C2A PIK3C2B PIK3CG

6.87e-07125239341793
Pubmed

Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.

PIK3C2A PIK3C2B PIK3CG

6.87e-071252312551992
Pubmed

HIV-1 Nef in macrophage-mediated disease pathogenesis.

PIK3C2A PIK3C2B PIK3CG

8.92e-071352323215766
Pubmed

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

PIK3C2A PIK3C2B PIK3CG

8.92e-07135239394803
Pubmed

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

PIK3C2A PIK3C2B PIK3CG

1.13e-061452317157319
Pubmed

HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.

PIK3C2A PIK3C2B PIK3CG

1.42e-061552318854243
Pubmed

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

SGCZ PIK3CG IRAG1

1.42e-061552320526338
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3C2A PIK3C2B PIK3CG

1.74e-061652316524887
Pubmed

HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

PIK3C2A PIK3C2B PIK3CG

1.74e-061652311289809
Pubmed

Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.

PIK3C2A PIK3C2B PIK3CG

1.74e-061652320019835
Pubmed

Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.

PIK3C2A PIK3C2B PIK3CG

1.74e-061652321029719
Pubmed

Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

PIK3C2A PIK3C2B PIK3CG

1.74e-061652320818790
Pubmed

Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.

PIK3C2A PIK3C2B PIK3CG

2.11e-061752323251686
Pubmed

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

PIK3C2A PIK3C2B PIK3CG

2.11e-061752312960231
Pubmed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.

PIK3C2A PIK3C2B PIK3CG

2.11e-061752318453587
Pubmed

Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.

PIK3C2A PIK3C2B

2.19e-06252232192434
Pubmed

Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

MTOR PIK3CG

2.19e-06252220166697
Pubmed

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.

PIK3C2A PIK3C2B

2.19e-06252214563213
Pubmed

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.

MAP4K3 MTOR

2.19e-06252222898570
Pubmed

Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis.

MTOR TLR7

2.19e-06252227566824
Pubmed

Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.

MTOR PIK3CG

2.19e-06252215496972
Pubmed

Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells.

MTOR PIK3CG

2.19e-06252220157617
Pubmed

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.

PIK3C2A PIK3C2B

2.19e-06252230374841
Pubmed

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

MAP4K3 MTOR

2.19e-06252220227368
Pubmed

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

PIK3C2A PIK3C2B PIK3CG

2.53e-061852312526811
Pubmed

HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.

PIK3C2A PIK3C2B PIK3CG

3.00e-061952324073214
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PIK3C2A PIK3C2B PIK3CG

4.11e-06215239446795
Pubmed

HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.

PIK3C2A PIK3C2B PIK3CG

4.76e-062252311994280
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PIK3C2A PIK3C2B PIK3CG

4.76e-062252311154208
Pubmed

HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.

PIK3C2A PIK3C2B PIK3CG

5.47e-062352323301033
Pubmed

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

PIK3C2A PIK3C2B PIK3CG

5.47e-062352319047410
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

LHCGR TRHR PIK3CG SLC6A5 ACTN2 CNTN1

5.72e-0630052619086053
Pubmed

Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.

MTOR PIK3CG

6.57e-06352219615795
Pubmed

Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase.

PIK3CG CDH2

6.57e-06352217646933
Pubmed

The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.

MTOR PIK3CG

6.57e-06352219897009
Pubmed

Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer.

MTOR PIK3CG

6.57e-06352218395956
Pubmed

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.

PIK3C2A PIK3C2B

6.57e-06352222128329
Pubmed

Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder.

MTOR PIK3CG

6.57e-06352221707707
Pubmed

Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients.

MTOR PIK3CG

6.57e-06352220530239
Pubmed

Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.

MTOR PIK3CG

6.57e-06352224008870
Pubmed

Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.

SLC44A2 CDH2

6.57e-06352234371293
Pubmed

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.

MTOR PIK3CG

6.57e-06352219078992
Pubmed

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.

MTOR PIK3CG

6.57e-06352218652687
Pubmed

N-RAP expression during mouse heart development.

ACTN2 CDH2

6.57e-06352215765519
Pubmed

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.

PIK3C2A PIK3C2B

6.57e-06352233387369
Pubmed

Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy.

MTOR PIK3CG

6.57e-06352220030877
Pubmed

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

MTOR PIK3CG

6.57e-06352215001544
Pubmed

Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.

MTOR PIK3CG

6.57e-06352220488790
Pubmed

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

PIK3C2A PIK3C2B

6.57e-06352225779105
Pubmed

Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.

PIK3C2A PIK3C2B PIK3CG

7.08e-062552315689238
Pubmed

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

PIK3C2A PIK3C2B PIK3CG

7.08e-062552317632570
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PIK3C2A PIK3C2B PIK3CG

8.99e-062752311156964
Pubmed

Perlecan is critical for heart stability.

DSP CDH2

1.31e-05452218694874
Pubmed

Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells.

MTOR CCNB1

1.31e-05452231387191
Pubmed

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

PIK3C2A PIK3C2B

1.31e-05452224098492
Pubmed

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.

MTOR PIK3CG

1.31e-05452217724079
Pubmed

A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

MTOR PIK3CG

1.31e-05452223107319
Pubmed

Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.

PIK3C2A PIK3C2B

1.31e-05452230476019
Pubmed

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

PIK3CG CDH2

1.31e-05452220847309
Pubmed

Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene.

LHCGR PIK3CG

2.19e-05552216943418
Pubmed

Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin.

MTOR PIK3CG

2.19e-05552217942603
Pubmed

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.

PIRT TLR7

2.19e-05552230033153
Pubmed

Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts.

MTOR PIK3CG

2.19e-05552218434090
Pubmed

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

PIRT TLR7

2.19e-05552233819485
Pubmed

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PIK3C2A PIK3C2B

2.19e-05552210805725
Pubmed

Promising molecular targets in ovarian cancer.

MTOR PIK3CG

2.19e-05552219553815
Pubmed

Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.

DSP CDH2

2.19e-05552212615965
Pubmed

Mapping of quantitative trait loci for ethanol preference in quasi-congenic strains.

KIF21A CNTN1

2.19e-05552210719795
Pubmed

Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.

PIK3C2A PIK3C2B

2.19e-05552220197460
Pubmed

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

TLR7 IL1RL1

2.19e-05552221623379
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 AXDND1 SGCD

2.77e-053952319010793
Pubmed

Establishment of cardiac cytoarchitecture in the developing mouse heart.

DSP ACTN2

3.28e-05652216337936
Pubmed

Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy.

SGCZ SGCD

3.28e-05652212189167
Pubmed

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

PIK3C2A MTOR

3.28e-05652222696681
Pubmed

Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.

ACTN2 CDH2

3.28e-05652224500875
Pubmed

ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.

ACTN2 CDH2

3.28e-05652235899771
Pubmed

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.

DSP ACTN2

4.58e-05752221659647
Pubmed

Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).

DSP CDH2

4.58e-05752219723622
Pubmed

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.

PIK3C2B PIK3CG

4.58e-05752218755982
Pubmed

Raptor is phosphorylated by cdc2 during mitosis.

MTOR CCNB1

4.58e-05752220169205
Pubmed

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.

DSP CDH2

4.58e-05752215479741
Pubmed

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.

DSP CDH2

6.10e-05852228827800
Pubmed

Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.

DSP CDH2

6.10e-05852220093627
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

PTPN9 PIK3C2B DSP MTOR CCNB1

7.11e-0528852523383273
Pubmed

Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development.

CDH2 CCNB1

7.84e-05952227986432
Pubmed

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

PIK3CG CDH2

7.84e-05952215192701
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

PIK3C2A DSP SGCD ACTN2 MRFAP1L1 CCNB1

9.64e-0549752623414517
CytobandEnsembl 112 genes in cytogenetic band chr12q12

KIF21A CNTN1

2.35e-0363522chr12q12
Cytoband19q13.3

KLK6 SYMPK

3.94e-038252219q13.3
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C2A PIK3C2B PIK3CG

4.39e-078373831
CoexpressionGSE3982_DC_VS_MAC_DN

UNC13B STUM PIK3CG CLEC5A TLR7 CCNB1

2.78e-06200526M5460
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SGCZ STUM PIK3CG ACTN2 CPVL

2.11e-061795251ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SGCZ STUM PIK3CG ACTN2 CPVL

2.22e-061815259de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

SGCD KIF21A ACTN2 CDH2 CPVL

3.04e-06193525dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

SGCD KIF21A ACTN2 CDH2 CPVL

3.20e-06195525f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LHCGR SGCD ACTN2 IRAG1 CDH2

3.45e-06198525e9f434bfd072e590fe44d518057ee5aa653038f3
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

2.16e-0514052411e441c3435ad8911ab401ca7d4ae1d3e5fa6eac
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

2.16e-0514052494444b92acfad64d811ebb1545dc1dab64473795
ToppCellControl-Myeloid-Dendritic_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLK6 TLR7 GPR171 CDH2

2.35e-05143524bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCellControl-Myeloid-Dendritic_cells-pDC|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLK6 TLR7 GPR171 CDH2

2.48e-05145524bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCellLA-15._Ventricular_Cardiomyocyte_III|LA / Chamber and Cluster_Paper

SGCD ACTN2 CDH2 CNTN1

2.62e-051475248970eb6b82589f39439c61a57d999661ec8342de
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B PCSK5 TRHR SGCD

2.76e-051495248638b3819193d11411df58964069fec583f617f4
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP-L6_NP_ALM_Trh|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B PCSK5 TRHR PIRT

2.76e-05149524fe9dff31a30dabd212d53d1295f9f13ff32cb217
ToppCellHippocampus-Hematopoietic|Hippocampus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7 IL1RL1

2.91e-0515152481b2189afd72658f7e2539b856ba79cd49340215
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

3.56e-051595245c7a099aa84ecc62bf9b5e1609e5b6b77889f175
ToppCellFrontal_cortex-Hematopoietic|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A RNASE12 TLR7

3.65e-0516052470ffbe61cfd729519b23569a43d929b117ab8d5e
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

4.12e-05165524004d793bf5bb6fb3b7bf38baf11b32d46375fe4d
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

4.52e-05169524e36b8cd0230bbb761df7606129ebfd77111af10b
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

SGCD ACTN2 CDH2 CPVL

4.62e-051705243f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B PIK3CG GPR171 MRFAP1L1

4.62e-0517052428fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

CLEC5A ACTN2 CDH2 CPVL

4.62e-051705244232fe937909f93d3736988c707b8f95ce993398
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3C2B PIK3CG GPR171 MRFAP1L1

4.62e-05170524239cb4b801b2d71a6facb386f2684c0851504151
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 KLK6 KIF21A CDH2

4.84e-05172524bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LHCGR SGCD ACTN2 IRAG1

4.95e-05173524cb6389536195443633adb06e5f1b7483530773d1
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SGCZ STUM PIK3CG CPVL

5.06e-05174524bc978a2148a0261a4f9d1ca5479b707e224566be
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHR PIK3C2A MTOR SGCD

5.06e-05174524f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR171 IL1RL1 ACTN2 CNTN1

5.29e-051765240f55de48bbc396c187f2a7d1d7da20862c715f9e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STUM PIK3CG ACTN2 CPVL

5.29e-051765240710689e66deba179b0a8038cdd56b4834984f12
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STUM PIK3CG ACTN2 CPVL

5.53e-051785246f61490d79cd1727ed2d5cc673823dd4efdafac1
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SGCZ DSP KIF21A PGC

6.03e-05182524d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STUM PIRT KIF21A CDH2

6.03e-05182524be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

SGCD KIF21A ACTN2 CDH2

6.16e-051835242902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCSK5 PIRT SGCD

6.62e-0567523b80bdd122a0284611161c40ec7a9c893dc8de4de
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 KIF21A XYLB CDH2

6.69e-05187524d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

6.69e-0518752478cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

SGCD ACTN2 CDH2 CPVL

6.83e-051885240758b474457efa36488e0195f7357100f4b6a090
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

6.98e-051895249c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STUM PIRT KIF21A CDH2

6.98e-05189524cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 SGCZ SGCD IRAG1

6.98e-0518952445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

SGCD ACTN2 CDH2 CPVL

7.12e-05190524de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 SGCD ACTN2 IRAG1

7.27e-0519152414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

7.27e-051915245d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

DSP KIF21A ACTN2 CPVL

7.41e-05192524f18da8db573e584c8b90df0814afcf020360108e
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

7.41e-05192524ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STUM PIRT KIF21A CDH2

7.56e-05193524a189d46c39067b717509cd144e0225cc93d7731d
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

7.72e-0519452489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

SGCD KIF21A ACTN2 CDH2

7.72e-05194524c3535f7cc0076653c72db582047cff053c322397
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

SGCD KIF21A ACTN2 CDH2

7.87e-0519552475fc81bddb246dca3b437fb60827b1d4fe416405
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGCZ KIF21A CDH2 ATP2B1

7.87e-051955243e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGCZ KIF21A CDH2 ATP2B1

7.87e-051955247796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LHCGR SGCD ACTN2 IRAG1

8.03e-051965245159d8625d80c20eb28157b2603c8bde9d377a35
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LHCGR SGCD ACTN2 IRAG1

8.03e-051965246b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 KLK6 KIF21A CDH2

8.19e-05197524bb35a2b7320fda92e9cd42f536b7bd54e3a73a32
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

STUM CPVL ATP2B1 CNTN1

8.19e-0519752479b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCellmedial-Hematologic-B_cell-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AXDND1 STUM MTOR CNTN1

8.19e-05197524095134c36f8d2a24c9085017b8d81f04a36cdd1d
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UNC13B DSP KIF21A PGC

8.19e-051975241485933986921ff45669d9b7501c8d17050b3e97
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK6 KIF21A CDH2 CCNB1

8.19e-05197524cd7e34318b4ae72b7b312fda8cc0e041c2ac4ab5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33|World / Primary Cells by Cluster

STUM CPVL ATP2B1 CNTN1

8.19e-05197524d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCellmedial-2-Hematologic-B_cell|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AXDND1 STUM MTOR CNTN1

8.19e-051975244b8c8b9b9a85ebe6862306c9e13089a24fc4e98a
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STUM PIRT KIF21A CNTN1

8.19e-05197524f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 KLK6 KIF21A CDH2

8.19e-051975241018aac22659c081d227d566afa29b1748c18ade
ToppCellmedial-Hematologic-B_cell|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AXDND1 STUM MTOR CNTN1

8.19e-05197524124c5107045069613493e3c61763eeca0a2119b6
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13B DSP KIF21A PGC

8.35e-05198524d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STUM PIRT KIF21A CDH2

8.35e-0519852450504a3871f76d6a5b439a56450d7770f4501eb0
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ERCC3 SGCD ACTN2 IRAG1

8.35e-05198524cbb63b255bdc92a557c5db1f08f7766ed9346607
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LHCGR ACTN2 IRAG1 CNTN1

8.35e-051985241e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KIF21A CDH2 TSPAN3 SYMPK

8.51e-051995246723287924750a2247a07ab6e561066a97b09771
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 KLK6 KIF21A CDH2

8.51e-051995241761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCellNeuronal-Excitatory-eF(C1QL3)|Neuronal / cells hierarchy compared to all cells using T-Statistic

STUM PIK3CG ACTN2 CPVL

8.68e-052005247668ae7ed550583ab59e419c5c9bb9f2d7e8e0d5
ToppCellNeuronal-Excitatory-eF(C1QL3)----L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

STUM PIK3CG ACTN2 CPVL

8.68e-0520052444f0278cb0e4ffcda4af3719d7f5819a10929b9f
ToppCellNeuronal-Excitatory-eF(C1QL3)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

STUM PIK3CG ACTN2 CPVL

8.68e-0520052423da7790e09575b2ca909ed16806b44223bf1017
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

KLK6 PIRT LMBR1L ACTN2

8.68e-05200524e16bde12326f0cfc4d03f9307cba0e21ea2389cb
ToppCellNeuronal-Excitatory-eF(C1QL3)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

STUM PIK3CG ACTN2 CPVL

8.68e-0520052491f3df1c5a661ff703835f58a35cee93f18eb15c
ToppCellNeuronal-Excitatory-eF(C1QL3)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

STUM PIK3CG ACTN2 CPVL

8.68e-052005242e2b1d252972b702ade25526ec8461bf613d81b0
ToppCellHippocampus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLEC5A RNASE12 TLR7

1.87e-04955236122a821dd1d1630ce11d219dcde6bd74e5487d1
ToppCellHippocampus-Hematopoietic-MICROGLIA-MI2(C1qb)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLEC5A RNASE12 TLR7

1.87e-04955238f058263d52099544488bd4ee1850d97dfd33de4
ToppCellHippocampus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLEC5A RNASE12 TLR7

1.87e-0495523ac03599e8e16465dbede1ce5c6a4176246d79fa1
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TRHR PIRT GPR171

1.87e-0495523ffbf3e362384c87b9db690ed39cd215e1f68375c
ToppCellHippocampus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLEC5A RNASE12 TLR7

1.87e-0495523d5f5af5bf542a72a4f9dba05277824b5c8b2fb6d
ToppCellHippocampus-Hematopoietic-MICROGLIA|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLEC5A RNASE12 TLR7

1.87e-0495523aa217fa29152df1dbc54d33f36e3f288a18ef417
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

LHCGR IRAG1 CPVL

1.93e-0496523cd0b9812727cad937cf840360a87a2382e570d39
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

LHCGR IRAG1 CPVL

1.93e-0496523f31bed26ed9bcaf82d443de304372991136b11e7
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

LHCGR IRAG1 CPVL

1.93e-049652331ed9e073e30d740b46c8b3f01ba0de94a701995
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LMBR1L MTOR GRAMD4

2.24e-0410152386acaa2502f61baa714ae988b73e3e73a71e897e
ToppCellPosterior_cortex-Hematopoietic-MACROPHAGE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG TLR7 IL1RL1

2.31e-0410252357ad3d48adeb41f6ab65883e61d3b1e74a94ad1a
ToppCellPosterior_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG TLR7 IL1RL1

2.31e-041025230ec549ee94da5f2d7275490e90d816c645f6d4fc
ToppCellPosterior_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG TLR7 IL1RL1

2.31e-0410252330fa92383898f370dabc41dd23d6907f14ba1a06
ToppCellPosterior_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG TLR7 IL1RL1

2.31e-04102523c58e09aaa11b664c7d99e91f903561fa18460f05
ToppCellPosterior_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PIK3CG TLR7 IL1RL1

2.31e-041025239392288e284b71f3a208d9f283e6e3c944b7dd10
ToppCellRV-03._Atrial_Cardiomyocyte|RV / Chamber and Cluster_Paper

AXDND1 SGCD ACTN2

2.51e-0410552349e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCellThalamus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--|Thalamus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7

3.12e-04113523f606c2003ce9b17f3c27a7c24ee6bf30f28a2b06
ToppCellThalamus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)|Thalamus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7

3.12e-041135239b239bfa00aa2d2e27d13d80fe54ef4f2fea49c0
ToppCellThalamus-Hematopoietic-MICROGLIA|Thalamus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7

3.12e-04113523b82c5dd560a0e309f2b79ca874b006f914baade7
ToppCellThalamus-Hematopoietic-MICROGLIA-MI2(C1qb)|Thalamus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7

3.12e-04113523d5e6f36d2d6afaadfbf60b56c16ed15775139ed4
ToppCellThalamus-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-|Thalamus / BrainAtlas - Mouse McCarroll V32

PIK3CG CLEC5A TLR7

3.12e-04113523a339ddee70054612afef3cc9dc156738202af4cd
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AXDND1 SGCD ACTN2

3.90e-041225231cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nrgn_(Inferior_colliculus)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

SGCZ TRHR ACTN2

4.49e-041285239a800beca5cfc7b41f5eed500d45064cfa61c5de
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nrgn_(Inferior_colliculus)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SGCZ TRHR ACTN2

4.49e-04128523920ede29f3de68e4d08644a1da53849e0c0973fb
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-pDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR7 GPR171 CDH2

4.59e-04129523454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCellprimary_visual_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PIK3CG RNASE12 TLR7

4.70e-041305233a0846b74ba34bd0e2a05b4f1f39f3940df93780
ToppCellLV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

SGCD ACTN2 CDH2

4.70e-04130523a3e12984fb61311e49cc76c59f74f4dffc48faa1
Drugdactolisib

PIK3C2A PIK3C2B MTOR PIK3CG

7.07e-0732504ctd:C531198
DrugZSTK474

PIK3C2B MTOR PIK3CG

8.29e-079503ctd:C510150
Drug1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

PIK3C2A PIK3C2B MTOR PIK3CG

9.09e-0734504ctd:C569670
Drugapigenin

TRHR PIK3C2A PIK3C2B PIK3CG CCNB1 SYMPK

3.04e-06184506CID005280443
Drughalenaquinone

PIK3C2A PIK3C2B PIK3CG

3.57e-0614503CID000370346
Drug4-hydroxyisoleucine

PIK3C2A PIK3C2B PIK3CG

4.45e-0615503CID000354197
Drugdeguelin

PIK3C2A PIK3C2B MTOR PIK3CG

6.46e-0655504CID000107935
Drugeverolimus

ERCC3 PIK3C2A PIK3C2B MTOR PIK3CG

1.21e-05136505CID006442177
DrugPI(3,4,5)P3

PTPN9 PIK3C2A PIK3C2B MTOR PIK3CG

1.82e-05148505CID000643963
Drug2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

LHCGR PIK3C2A PIK3C2B MTOR PIK3CG TLR7 CDH2

2.55e-05400507ctd:C085911
DrugNSC-683864

ERCC3 PIK3C2A PIK3C2B MTOR PIK3CG

3.24e-05167505CID000148191
Drug2-phenyl-4-oxohydroquinoline

MTOR CCNB1

4.71e-055502ctd:C084179
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

UNC13B PCSK5 DSP TLR7 ACTN2

6.15e-051915053058_UP
Drug1-cyclopenta-2,4-dienylmethanol;cyclopentane;iron

DSP PGC

7.05e-056502CID011986411
DrugAC1OAGKB

PTPN9 PIK3C2A PIK3C2B MTOR PIK3CG

7.29e-05198505CID006857406
DrugFTI-277

PIK3C2A PIK3C2B MTOR PIK3CG

8.67e-05106504CID003005531
Diseaseage at onset, multiple sclerosis

PCSK5 AXDND1 SGCD

4.51e-0710473EFO_0004847, MONDO_0005301
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DSP ACTN2 CDH2

4.51e-0710473DOID:0050431 (is_implicated_in)
Diseasedilated cardiomyopathy 1L (implicated_via_orthology)

SGCZ SGCD

7.44e-063472DOID:0110436 (implicated_via_orthology)
DiseaseCardiomyopathy

DSP SGCD ACTN2

5.85e-0547473cv:C0878544
Diseaselymphatic vessel endothelial hyaluronic acid receptor 1 measurement

ST3GAL4 IRAG1

6.91e-058472EFO_0020539
Diseaseinterleukin 1 receptor-like 1 measurement

ST3GAL4 IL1RL1

1.35e-0411472EFO_0008168
Diseasebody weight

UNC13B PCSK5 LHCGR SGCZ PTPN9 MTOR SLC44A2 CPVL TMEM18

1.45e-041261479EFO_0004338
DiseaseST2 protein measurement

ST3GAL4 IL1RL1

5.12e-0421472EFO_0010599
Diseasemuscular dystrophy (implicated_via_orthology)

SGCZ SGCD

5.12e-0421472DOID:9884 (implicated_via_orthology)
DiseasePrimary familial dilated cardiomyopathy

SGCD ACTN2

1.05e-0330472cv:C0340427
Diseasespontaneous coronary artery dissection

ATP2B1 CNTN1

1.12e-0331472EFO_0010820
Diseaserenal cell carcinoma (is_marker_for)

KLK6 MTOR CCNB1

1.12e-03128473DOID:4450 (is_marker_for)
DiseaseCardiomyopathies

DSP SGCD ACTN2

1.18e-03130473C0878544
Diseasefactor VIII measurement, venous thromboembolism

SLC44A2 ST3GAL4

1.35e-0334472EFO_0004286, EFO_0004630
DiseasePrimary dilated cardiomyopathy

SGCD ACTN2

1.35e-0334472cv:C0007193

Protein segments in the cluster

PeptideGeneStartEntry
VVKKLQEIMMHVIWA

TSPAN3

201

O60637
NVKMTLGMIWTIILR

ACTN2

126

P35609
MADILEKIKNLFMWV

GRAMD4

316

Q6IC98
PLKAVQMLWVNLIMD

ATP2B1

881

P20020
WVIEQMVILMAVFAL

OR6C2

191

Q9NZP2
FWLMVWEQKVLVIVM

PTPN9

386

P43378
WVVINLVMLLAEMKI

LBR

396

Q14739
EIAKMAEMLVELVWR

MRFAP1L1

106

Q96HT8
MALEVLMLLAVLIWT

OOSP2

1

Q86WS3
IVLLEWVEPMQKFML

MAP4K3

696

Q8IVH8
IWLINILAIMGNMTV

LHCGR

366

P22888
MVGAMWKVIVSLVLL

CPVL

1

Q9H3G5
VIWMMAAVMLVLTVV

IRAG1

846

Q9Y6F6
MMLVLLLGAAVVVWK

PCSK5

1751

Q92824
DMLALQMIKIMDKIW

PIK3C2A

1146

O00443
AKMISTVVWLMVLLI

GPR171

131

O14626
KEWSLMIMKTLIVAV

MARCHF6

711

O60337
WDLIMLLLMVGNLIV

HCN3

96

Q9P1Z3
DMLTLQMIRIMSKIW

PIK3C2B

1091

O00750
QMIRIMSKIWVQEGL

PIK3C2B

1096

O00750
MRAILIDWLVQVQMK

CCNB1

201

P14635
MLINVLVIILKMFWI

IL1RL1

341

Q01638
LHISMIQWMVNLLIL

AXDND1

701

Q5T1B0
IQWMVNLLILMIPNF

AXDND1

706

Q5T1B0
TWMLMELQKIRRQIE

DSP

666

P15924
MKMWLLVSHLVIISI

CNTN1

1

Q12860
MWRKLMVEPLQAILI

CUL2

146

Q13617
LAGIMVWVMIIMVIL

SLC44A2

256

Q8IWA5
VMEWLKTQEWGLMIL

ERCC3

426

P19447
MIIMVIIFLVLLFWE

RNASE12

1

Q5GAN4
LILVLMFVVWMKRRD

CDH2

736

P19022
LEMRKWVDELFIIIM

MTOR

811

P42345
KMLAVVVILFALLWM

TRHR

266

P34981
VIWIPIMFVIKMHLA

SLC6A5

726

Q9Y345
VMLMLLTLLVLGMVW

LMBR1L

156

Q6UX01
IVSSALMIWKGLMVI

SEC11B

16

P0C7V7
LMMLVCGLVWVPIIK

PIRT

101

P0C851
RWKLLAMLALVLVVM

ST3GAL4

6

Q11206
TMIVNLAMTIWILKV

SGCZ

46

Q96LD1
IIPWVVMQELDRMKE

SWT1

421

Q5T5J6
MNWHMIISGLIVVVL

CLEC5A

1

Q9NY25
DMLILQILRIMESIW

PIK3CG

841

P48736
MMKSLRVLLVILWLQ

TRAV12-3

1

A0A0B4J271
MKWMVVVLVCLQLLE

PGC

1

P20142
MKWQLLERRVTDIIM

KIF21A

921

Q7Z4S6
LMILILVNLAMTIWI

SGCD

41

Q92629
LVNLAMTIWILKVMN

SGCD

46

Q92629
LIQILTAIVMVGWIM

STUM

101

Q69YW2
LMWVQALDIILEKMK

XYLB

66

O75191
RVLKELWRVVMNTME

UNC13B

1291

O14795
MVFPMWTLKRQILIL

TLR7

1

Q9NYK1
VMNILSRLIMKQVWK

SYMPK

1016

Q92797
VVLMVMGITLDKWVE

TMEM225

21

Q6GV28
SQLMLWIMELILWKF

nan

16

Q6ZVU0
LLVNAMIIVVMWVWK

TMEM18

101

Q96B42
MIIVVMWVWKTLNVM

TMEM18

106

Q96B42
MKKLMVVLSLIAAAW

KLK6

1

Q92876